BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 312088 CN1C2=NC(C)(C)CN2c2nn(Cc3ccc(cc3)C(C)=O)c(Nc3ccc(F)cc3)c2C1=O InChI=1S/C25H25FN6O2/c1-15(33)17-7-5-16(6-8-17)13-32-21(27-19-11-9-18(26)10-12-19)20-22(29-32)31-14-25(2,3)28-24(31)30(4)23(20)34/h5-12,27H,13-14H2,1-4H3 RKEUHNQOPBPRQD-UHFFFAOYSA-N 168126 US9073936, 1::US9598426, 1 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.2 7.5 30.00 C US Patent 10.7270/Q2348J5T aid1801415 US9073936 Li, P; Zheng, H; Zhao, J; Wennogle, LP Intra-Cellular Therapies Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168126&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 90409046 312525529 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 312089 CC(O)c1ccc(Cn2nc3N4CC(C)(C)N=C4N(C)C(=O)c3c2Nc2ccc(F)cc2)cc1 InChI=1S/C25H27FN6O2/c1-15(33)17-7-5-16(6-8-17)13-32-21(27-19-11-9-18(26)10-12-19)20-22(29-32)31-14-25(2,3)28-24(31)30(4)23(20)34/h5-12,15,27,33H,13-14H2,1-4H3 PSUHAEXBWCRQED-UHFFFAOYSA-N 168127 US9073936, 2::US9598426, 2 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.5 7.5 30.00 C US Patent 10.7270/Q2348J5T aid1801415 US9073936 Li, P; Zheng, H; Zhao, J; Wennogle, LP Intra-Cellular Therapies Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168127&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 86279224 312525530 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 312090 CN1C2=NC(C)(C)CN2c2nn(Cc3ccc(cc3)C(C)=O)c(Nc3ccc(F)c(F)c3)c2C1=O InChI=1S/C25H24F2N6O2/c1-14(34)16-7-5-15(6-8-16)12-33-21(28-17-9-10-18(26)19(27)11-17)20-22(30-33)32-13-25(2,3)29-24(32)31(4)23(20)35/h5-11,28H,12-13H2,1-4H3 ITYGOFCAYSOSFS-UHFFFAOYSA-N 168128 US9073936, 3::US9598426, 3 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.3 7.5 30.00 C US Patent 10.7270/Q2348J5T aid1801415 US9073936 Li, P; Zheng, H; Zhao, J; Wennogle, LP Intra-Cellular Therapies Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168128&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 86279223 312525531 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 312091 CN1C2=NC(C)(C)CN2c2nn(Cc3ccc(cc3)C(C)=O)c(Nc3ccc(F)c(C)c3)c2C1=O InChI=1S/C26H27FN6O2/c1-15-12-19(10-11-20(15)27)28-22-21-23(32-14-26(3,4)29-25(32)31(5)24(21)35)30-33(22)13-17-6-8-18(9-7-17)16(2)34/h6-12,28H,13-14H2,1-5H3 KQMWFBJUYHOBDC-UHFFFAOYSA-N 168129 US9073936, 4::US9598426, 4 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.1 7.5 30.00 C US Patent 10.7270/Q2348J5T aid1801415 US9073936 Li, P; Zheng, H; Zhao, J; Wennogle, LP Intra-Cellular Therapies Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168129&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 86279161 312525532 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 312092 CN1C2=NC(C)(C)CN2c2nn(Cc3ccc(cc3)C(C)=O)c(Nc3ccc(F)cc3)c2C1=O InChI=1S/C25H25FN6O2/c1-15(33)17-7-5-16(6-8-17)13-32-21(27-19-11-9-18(26)10-12-19)20-22(29-32)31-14-25(2,3)28-24(31)30(4)23(20)34/h5-12,27H,13-14H2,1-4H3 RKEUHNQOPBPRQD-UHFFFAOYSA-N 168126 US9073936, 1::US9598426, 1 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1 7.5 30.00 C US Patent 10.7270/Q2348J5T aid1801415 US9073936 Li, P; Zheng, H; Zhao, J; Wennogle, LP Intra-Cellular Therapies Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168126&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 90409046 312525529 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 312093 CC(O)c1ccc(Cn2nc3N4CC(C)(C)N=C4N(C)C(=O)c3c2Nc2ccc(F)cc2)cc1 InChI=1S/C25H27FN6O2/c1-15(33)17-7-5-16(6-8-17)13-32-21(27-19-11-9-18(26)10-12-19)20-22(29-32)31-14-25(2,3)28-24(31)30(4)23(20)34/h5-12,15,27,33H,13-14H2,1-4H3 PSUHAEXBWCRQED-UHFFFAOYSA-N 168127 US9073936, 2::US9598426, 2 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4 7.5 30.00 C US Patent 10.7270/Q2348J5T aid1801415 US9073936 Li, P; Zheng, H; Zhao, J; Wennogle, LP Intra-Cellular Therapies Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168127&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 86279224 312525530 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 312094 CN1C2=NC(C)(C)CN2c2nn(Cc3ccc(cc3)C(C)=O)c(Nc3ccc(F)c(F)c3)c2C1=O InChI=1S/C25H24F2N6O2/c1-14(34)16-7-5-15(6-8-16)12-33-21(28-17-9-10-18(26)19(27)11-17)20-22(30-33)32-13-25(2,3)29-24(32)31(4)23(20)35/h5-11,28H,12-13H2,1-4H3 ITYGOFCAYSOSFS-UHFFFAOYSA-N 168128 US9073936, 3::US9598426, 3 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4 7.5 30.00 C US Patent 10.7270/Q2348J5T aid1801415 US9073936 Li, P; Zheng, H; Zhao, J; Wennogle, LP Intra-Cellular Therapies Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168128&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 86279223 312525531 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 312095 CN1C2=NC(C)(C)CN2c2nn(Cc3ccc(cc3)C(C)=O)c(Nc3ccc(F)c(C)c3)c2C1=O InChI=1S/C26H27FN6O2/c1-15-12-19(10-11-20(15)27)28-22-21-23(32-14-26(3,4)29-25(32)31(5)24(21)35)30-33(22)13-17-6-8-18(9-7-17)16(2)34/h6-12,28H,13-14H2,1-5H3 KQMWFBJUYHOBDC-UHFFFAOYSA-N 168129 US9073936, 4::US9598426, 4 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.4 7.5 30.00 C US Patent 10.7270/Q2348J5T aid1801415 US9073936 Li, P; Zheng, H; Zhao, J; Wennogle, LP Intra-Cellular Therapies Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168129&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 86279161 312525532 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 412291 CC(C)(C)C1=NN(C(C1)c1ccc(Cl)cc1Cl)c1ccc(cc1)C(O)=O InChI=1S/C20H20Cl2N2O2/c1-20(2,3)18-11-17(15-9-6-13(21)10-16(15)22)24(23-18)14-7-4-12(5-8-14)19(25)26/h4-10,17H,11H2,1-3H3,(H,25,26) DIZHQHRVPINGBC-UHFFFAOYSA-N 236643 US9388139, 12 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >50000 US Patent 10.7270/Q2GF0SFS aid1803098 US9388139 Piazza, GA; Abadi, AH German University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236643 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236643&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 60194756 340130226 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 412292 CC(C)(C)C1=NN(C(C1)c1ccc(Cl)cc1Cl)c1ccc(cc1)C(O)=O InChI=1S/C20H20Cl2N2O2/c1-20(2,3)18-11-17(15-9-6-13(21)10-16(15)22)24(23-18)14-7-4-12(5-8-14)19(25)26/h4-10,17H,11H2,1-3H3,(H,25,26) DIZHQHRVPINGBC-UHFFFAOYSA-N 236643 US9388139, 12 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >50000 US Patent 10.7270/Q2GF0SFS aid1803098 US9388139 Piazza, GA; Abadi, AH German University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236643 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236643&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 60194756 340130226 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51223700 COc1cc2C(=NC(Cc2cc1OC1CCCC1)C(=O)Nc1ccccc1OC(F)(F)F)c1ccccc1 InChI=1S/C29H27F3N2O4/c1-36-25-17-21-19(16-26(25)37-20-11-5-6-12-20)15-23(33-27(21)18-9-3-2-4-10-18)28(35)34-22-13-7-8-14-24(22)38-29(30,31)32/h2-4,7-10,13-14,16-17,20,23H,5-6,11-12,15H2,1H3,(H,34,35) KZKPKVMAYKNNDQ-UHFFFAOYSA-N 50502858 CHEMBL4451855 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >200000 ChEMBL 10.1016/j.bmcl.2019.126720 10.7270/Q25X2D6W 31610942 Liao, Y; Jia, X; Tang, Y; Li, S; Zang, Y; Wang, L; Cui, ZN; Song, G South China Agricultural University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50502858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50502858&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 155521936 440711443 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 50236914 CCCCOc1cncc(c1)-c1nnc2c(C)nc3ccc(CN4CCOCC4)cc3n12 InChI=1S/C24H28N6O2/c1-3-4-9-32-20-13-19(14-25-15-20)24-28-27-23-17(2)26-21-6-5-18(12-22(21)30(23)24)16-29-7-10-31-11-8-29/h5-6,12-15H,3-4,7-11,16H2,1-2H3 JJQZDOKXARNTKH-UHFFFAOYSA-N 50026821 CHEMBL3331521::US11419874, Example 10::US9669035, B-1b Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >10000 ChEMBL 10.1021/ml500262u 10.7270/Q2QN68DN 25221665 Buijnsters, P; De Angelis, M; Langlois, X; Rombouts, FJ; Sanderson, W; Tresadern, G; Ritchie, A; Trabanco, AA; VanHoof, G; Roosbroeck, YV; Andrés, JI Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026821&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search Q2T 71153408 103936405 CHEMBL3331521 ZINC28227929 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 50303891 CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1 InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29) BNRNXUUZRGQAQC-UHFFFAOYSA-N 14390 5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one::5-{2-ethoxy-5-[(4-methylpiperazine-1-)sulfonyl]phenyl}-1-methyl-3-propyl-1H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one::CHEMBL192::SILDENAFIL CITRATE::Sildenafil::Sildenafil#::US11155558, Compound sildenafil::US11242347, Compound sildenafil::Viagra Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 600 ChEMBL 10.1016/j.bmc.2015.03.005 10.7270/Q28917JN 25801159 Sawant, SD; Lakshma Reddy, G; Dar, MI; Srinivas, M; Gupta, G; Sahu, PK; Mahajan, P; Nargotra, A; Singh, S; Sharma, SC; Tikoo, M; Singh, G; Vishwakarma, RA; Syed, SH CSIR-Indian Institute of Integrative Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14390&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search VIA 5212 46514731 9139 CHEMBL192 4743 C07259 ZINC19796168 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 50303896 CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)NCCCCCCO InChI=1S/C23H33N5O5S/c1-4-10-18-20-21(28(3)27-18)23(30)26-22(25-20)17-15-16(11-12-19(17)33-5-2)34(31,32)24-13-8-6-7-9-14-29/h11-12,15,24,29H,4-10,13-14H2,1-3H3,(H,25,26,30) NWAWSQQMTQQBGL-UHFFFAOYSA-N 50067186 CHEMBL3401745 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 62 ChEMBL 10.1016/j.bmc.2015.03.005 10.7270/Q28917JN 25801159 Sawant, SD; Lakshma Reddy, G; Dar, MI; Srinivas, M; Gupta, G; Sahu, PK; Mahajan, P; Nargotra, A; Singh, S; Sharma, SC; Tikoo, M; Singh, G; Vishwakarma, RA; Syed, SH CSIR-Indian Institute of Integrative Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50067186 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50067186&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 118728649 103961684 CHEMBL3401745 ZINC13781399 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 50336274 Cc1nc2ccncc2n2c(nnc12)-c1ccccc1Cl InChI=1S/C15H10ClN5/c1-9-14-19-20-15(10-4-2-3-5-11(10)16)21(14)13-8-17-7-6-12(13)18-9/h2-8H,1H3 SNQXTEAQGLZIDL-UHFFFAOYSA-N 162879 US11419874, Example 28::US9056863, Example Ic1 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >10000 ChEMBL 10.1021/ml500463t 10.7270/Q2319XMJ 25815146 Rombouts, FJ; Tresadern, G; Buijnsters, P; Langlois, X; Tovar, F; Steinbrecher, TB; Vanhoof, G; Somers, M; Andrés, JI; Trabanco, AA Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=162879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=162879&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 71295299 310304816 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 50432883 COc1ccc(CNC(=O)c2ccc(OC(F)F)c(OC3CCCC3)c2)cc1 InChI=1S/C21H23F2NO4/c1-26-16-9-6-14(7-10-16)13-24-20(25)15-8-11-18(28-21(22)23)19(12-15)27-17-4-2-3-5-17/h6-12,17,21H,2-5,13H2,1H3,(H,24,25) DBNDIIUELFNMBG-UHFFFAOYSA-N 50129817 CHEMBL3628685 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >100000 ChEMBL 10.1016/j.bmc.2015.10.033 10.7270/Q2GQ70KG 26526739 Zhou, ZZ; Ge, BC; Chen, YF; Shi, XD; Yang, XM; Xu, JP Southern Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129817&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122193679 321902957 CHEMBL3628685 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 50454929 COCc1nc2n(CC(C)C)c(=O)n(C)c(=O)c2[nH]1 InChI=1S/C12H18N4O3/c1-7(2)5-16-10-9(11(17)15(3)12(16)18)13-8(14-10)6-19-4/h7H,5-6H2,1-4H3,(H,13,14) NBLBCGUCPBXKOV-UHFFFAOYSA-N 50059035 3-Isobutyl-8-methoxymethyl-1-methyl-3,7-dihydro-purine-2,6-dione::3-Isobutyl-8-methoxymethyl-1-methyl-3,9-dihydro-purine-2,6-dione::3-isobutyl-8-(methoxymethyl)-1-methyl-1H-purine-2,6(3H,7H)-dione::CHEMBL307639 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 10000 ChEMBL 10.1016/j.bmcl.2009.03.007 10.7270/Q2D79B9B 19303290 Akama, T; Baker, SJ; Zhang, YK; Hernandez, V; Zhou, H; Sanders, V; Freund, Y; Kimura, R; Maples, KR; Plattner, JJ Anacor Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50059035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50059035&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 155806 103954937 CHEMBL307639 ZINC14806781 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 50454930 OB1OCc2cc(Oc3ccc(cc3)C#N)ccc12 InChI=1S/C14H10BNO3/c16-8-10-1-3-12(4-2-10)19-13-5-6-14-11(7-13)9-18-15(14)17/h1-7,17H,9H2 USZAGAREISWJDP-UHFFFAOYSA-N 50277665 4-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yloxy)benzonitrile::5-(4-cyanophenoxy)-2,3-dihydro-1-hydroxy-2,1-benzoxaborole::AN-2728::CHEMBL484785::Crisaborole::Eucrisa Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 6100 ChEMBL 10.1016/j.bmcl.2009.03.007 10.7270/Q2D79B9B 19303290 Akama, T; Baker, SJ; Zhang, YK; Hernandez, V; Zhou, H; Sanders, V; Freund, Y; Kimura, R; Maples, KR; Plattner, JJ Anacor Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50277665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50277665&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 44591583 104120185 CHEMBL484785 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 50457341 CC(C)c1[nH]nc2c1nc(C[C@@H]1CCCC[C@H]1Nc1ncc(C(O)=O)c(n1)C(F)(F)F)[nH]c2=O InChI=1S/C21H24F3N7O3/c1-9(2)14-15-16(31-30-14)18(32)28-13(27-15)7-10-5-3-4-6-12(10)26-20-25-8-11(19(33)34)17(29-20)21(22,23)24/h8-10,12H,3-7H2,1-2H3,(H,30,31)(H,33,34)(H,25,26,29)(H,27,28,32)/t10-,12+/m0/s1 UJQKNBFBUSXTSO-CMPLNLGQSA-N 50259148 (-)2-({(trans)-2-[(3-isopropyl-7-oxo-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)methyl]cyclohexyl}amino)-4-(trifluoromethyl)pyrimidine-5-carboxylic acid::CHEMBL466280 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >10000 ChEMBL 10.1016/j.bmcl.2009.03.024 10.7270/Q2RB74GG 19339180 Deninno, MP; Andrews, M; Bell, AS; Chen, Y; Eller-Zarbo, C; Eshelby, N; Etienne, JB; Moore, DE; Palmer, MJ; Visser, MS; Yu, LJ; Zavadoski, WJ; Michael Gibbs, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259148&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 44574673 104109552 CHEMBL466280 ZINC40879714 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 50457342 CC(C)c1[nH]nc2c1nc(C[C@@H]1CCCC[C@H]1Nc1ccc(C)nn1)[nH]c2=O InChI=1S/C20H27N7O/c1-11(2)17-18-19(27-26-17)20(28)23-16(22-18)10-13-6-4-5-7-14(13)21-15-9-8-12(3)24-25-15/h8-9,11,13-14H,4-7,10H2,1-3H3,(H,21,25)(H,26,27)(H,22,23,28)/t13-,14+/m0/s1 PMRWYXIODMVINY-UONOGXRCSA-N 50259107 3-isopropyl-5-(((1S, 2R)-2-(6-methylpyridazin-3-ylamino)cyclohexyl)methyl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one::CHEMBL513304 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >10000 ChEMBL 10.1016/j.bmcl.2009.03.024 10.7270/Q2RB74GG 19339180 Deninno, MP; Andrews, M; Bell, AS; Chen, Y; Eller-Zarbo, C; Eshelby, N; Etienne, JB; Moore, DE; Palmer, MJ; Visser, MS; Yu, LJ; Zavadoski, WJ; Michael Gibbs, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259107&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 44574635 104109529 CHEMBL513304 ZINC40876527 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 50457343 CC(C)c1[nH]nc2c1nc(C[C@@H]1CCCC[C@H]1NC(=O)NCCCN1CCOCC1)[nH]c2=O InChI=1S/C23H37N7O3/c1-15(2)19-20-21(29-28-19)22(31)27-18(26-20)14-16-6-3-4-7-17(16)25-23(32)24-8-5-9-30-10-12-33-13-11-30/h15-17H,3-14H2,1-2H3,(H,28,29)(H2,24,25,32)(H,26,27,31)/t16-,17+/m0/s1 WXHYNZHWBZIGJP-DLBZAZTESA-N 50259106 1-{(1R,2S)-2-[(3-isopropyl-7-oxo-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)methyl]cyclohexyl}-3-(3-morpholin-4-ylpropyl)urea::CHEMBL466480 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >10000 ChEMBL 10.1016/j.bmcl.2009.03.024 10.7270/Q2RB74GG 19339180 Deninno, MP; Andrews, M; Bell, AS; Chen, Y; Eller-Zarbo, C; Eshelby, N; Etienne, JB; Moore, DE; Palmer, MJ; Visser, MS; Yu, LJ; Zavadoski, WJ; Michael Gibbs, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259106&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 44574634 104109528 CHEMBL466480 ZINC40876524 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 50457344 CC(C)c1[nH]nc2c1nc(C[C@@H]1CCCC[C@H]1NC(=O)CC1CCOCC1)[nH]c2=O InChI=1S/C22H33N5O3/c1-13(2)19-20-21(27-26-19)22(29)25-17(24-20)12-15-5-3-4-6-16(15)23-18(28)11-14-7-9-30-10-8-14/h13-16H,3-12H2,1-2H3,(H,23,28)(H,26,27)(H,24,25,29)/t15-,16+/m0/s1 YYXRNUDRJVHKAD-JKSUJKDBSA-N 50259105 CHEMBL466680::N-{(1R,2S)-2-[(3-isopropyl-7-oxo-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)methyl]cyclohexyl}-2-(tetrahydro-2H-pyran-4-yl)acetamide Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >10000 ChEMBL 10.1016/j.bmcl.2009.03.024 10.7270/Q2RB74GG 19339180 Deninno, MP; Andrews, M; Bell, AS; Chen, Y; Eller-Zarbo, C; Eshelby, N; Etienne, JB; Moore, DE; Palmer, MJ; Visser, MS; Yu, LJ; Zavadoski, WJ; Michael Gibbs, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259105&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 44574633 104109527 CHEMBL466680 ZINC40881409 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 50457345 CC(C)c1[nH]nc2c1nc(C[C@@H]1CCCC[C@H]1NC(=O)CN1CCCC1)[nH]c2=O InChI=1S/C21H32N6O2/c1-13(2)18-19-20(26-25-18)21(29)24-16(23-19)11-14-7-3-4-8-15(14)22-17(28)12-27-9-5-6-10-27/h13-15H,3-12H2,1-2H3,(H,22,28)(H,25,26)(H,23,24,29)/t14-,15+/m0/s1 SEYCIBHCEGUQNB-LSDHHAIUSA-N 50259060 CHEMBL466475::N-[(1R,2S)2-(3-Isopropyl-7-oxo-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-ylmethyl)-cyclohex-1-yl]-2-pyrrolidin-1-yl-acetamide Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >10000 ChEMBL 10.1016/j.bmcl.2009.03.024 10.7270/Q2RB74GG 19339180 Deninno, MP; Andrews, M; Bell, AS; Chen, Y; Eller-Zarbo, C; Eshelby, N; Etienne, JB; Moore, DE; Palmer, MJ; Visser, MS; Yu, LJ; Zavadoski, WJ; Michael Gibbs, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259060&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 11211753 104109507 CHEMBL466475 ZINC40875758 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 50457346 CC(C)c1[nH]nc2c1nc(C[C@@H]1CCCC[C@H]1OCCN1CCOCC1)[nH]c2=O InChI=1S/C21H33N5O3/c1-14(2)18-19-20(25-24-18)21(27)23-17(22-19)13-15-5-3-4-6-16(15)29-12-9-26-7-10-28-11-8-26/h14-16H,3-13H2,1-2H3,(H,24,25)(H,22,23,27)/t15-,16+/m0/s1 DHNHXAUERSTPRA-JKSUJKDBSA-N 50259059 3-isopropyl-5-{[(1S,2R)-2-(2-morpholin-4-ylethoxy)cyclohexyl]methyl}-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one::CHEMBL513129 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >10000 ChEMBL 10.1016/j.bmcl.2009.03.024 10.7270/Q2RB74GG 19339180 Deninno, MP; Andrews, M; Bell, AS; Chen, Y; Eller-Zarbo, C; Eshelby, N; Etienne, JB; Moore, DE; Palmer, MJ; Visser, MS; Yu, LJ; Zavadoski, WJ; Michael Gibbs, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259059&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 44574590 104109506 CHEMBL513129 ZINC40395257 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 50457349 CC(C)c1[nH]nc2c1nc(C[C@@H]1CCCC[C@H]1Nc1ncccn1)[nH]c2=O InChI=1S/C19H25N7O/c1-11(2)15-16-17(26-25-15)18(27)24-14(23-16)10-12-6-3-4-7-13(12)22-19-20-8-5-9-21-19/h5,8-9,11-13H,3-4,6-7,10H2,1-2H3,(H,25,26)(H,20,21,22)(H,23,24,27)/t12-,13+/m0/s1 BJVCVIRGZHSCSW-QWHCGFSZSA-N 50259108 (-)3-Isopropyl-5-{[(trans)-2-(pyrimidin-2-ylamino)cyclohexyl]methyl}-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one::CHEMBL466481 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 7700 ChEMBL 10.1016/j.bmcl.2009.03.024 10.7270/Q2RB74GG 19339180 Deninno, MP; Andrews, M; Bell, AS; Chen, Y; Eller-Zarbo, C; Eshelby, N; Etienne, JB; Moore, DE; Palmer, MJ; Visser, MS; Yu, LJ; Zavadoski, WJ; Michael Gibbs, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259108&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 42629121 104109530 CHEMBL466481 ZINC40395708 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 50457354 CC(C)c1[nH]nc2c1nc(Cc1ccccc1OCCN1CCOCC1)[nH]c2=O InChI=1S/C21H27N5O3/c1-14(2)18-19-20(25-24-18)21(27)23-17(22-19)13-15-5-3-4-6-16(15)29-12-9-26-7-10-28-11-8-26/h3-6,14H,7-13H2,1-2H3,(H,24,25)(H,22,23,27) DQQIKKSUASWOMX-UHFFFAOYSA-N 50259057 3-isopropyl-5-(2-(2-morpholinoethoxy)benzyl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one::CHEMBL466068 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 3900 ChEMBL 10.1016/j.bmcl.2009.03.024 10.7270/Q2RB74GG 19339180 Deninno, MP; Andrews, M; Bell, AS; Chen, Y; Eller-Zarbo, C; Eshelby, N; Etienne, JB; Moore, DE; Palmer, MJ; Visser, MS; Yu, LJ; Zavadoski, WJ; Michael Gibbs, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259057&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 11773870 104109504 CHEMBL466068 ZINC36424810 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 50457358 CC(C)c1[nH]nc2c1nc(Cc1ccccc1OC(F)(F)F)[nH]c2=O InChI=1S/C16H15F3N4O2/c1-8(2)12-13-14(23-22-12)15(24)21-11(20-13)7-9-5-3-4-6-10(9)25-16(17,18)19/h3-6,8H,7H2,1-2H3,(H,22,23)(H,20,21,24) RCKCFOKBILAFJF-UHFFFAOYSA-N 50259016 3-isopropyl-5-(2-(trifluoromethoxy)benzyl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one::CHEMBL467282 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2500 ChEMBL 10.1016/j.bmcl.2009.03.024 10.7270/Q2RB74GG 19339180 Deninno, MP; Andrews, M; Bell, AS; Chen, Y; Eller-Zarbo, C; Eshelby, N; Etienne, JB; Moore, DE; Palmer, MJ; Visser, MS; Yu, LJ; Zavadoski, WJ; Michael Gibbs, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259016&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 9903124 104109491 CHEMBL467282 ZINC34021820 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 50457360 CC(C)c1[nH]nc2c1nc(Cc1ccccc1OCc1ccccc1)[nH]c2=O InChI=1S/C22H22N4O2/c1-14(2)19-20-21(26-25-19)22(27)24-18(23-20)12-16-10-6-7-11-17(16)28-13-15-8-4-3-5-9-15/h3-11,14H,12-13H2,1-2H3,(H,25,26)(H,23,24,27) ZQBYOGSAPCTBKD-UHFFFAOYSA-N 50259017 5-(2-(benzyloxy)benzyl)-3-isopropyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one::CHEMBL511564 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1430 ChEMBL 10.1016/j.bmcl.2009.03.024 10.7270/Q2RB74GG 19339180 Deninno, MP; Andrews, M; Bell, AS; Chen, Y; Eller-Zarbo, C; Eshelby, N; Etienne, JB; Moore, DE; Palmer, MJ; Visser, MS; Yu, LJ; Zavadoski, WJ; Michael Gibbs, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259017&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 22277570 104109492 CHEMBL511564 ZINC40395157 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 50457364 CC(C)c1nn(C)c2c1nc(Cc1ccccc1OCCN1CCOCC1)[nH]c2=O InChI=1S/C22H29N5O3/c1-15(2)19-20-21(26(3)25-19)22(28)24-18(23-20)14-16-6-4-5-7-17(16)30-13-10-27-8-11-29-12-9-27/h4-7,15H,8-14H2,1-3H3,(H,23,24,28) MMFHEXODWCOMFW-UHFFFAOYSA-N 50259058 3-isopropyl-1-methyl-5-(2-(2-morpholinoethoxy)benzyl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one::CHEMBL466474 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 790 ChEMBL 10.1016/j.bmcl.2009.03.024 10.7270/Q2RB74GG 19339180 Deninno, MP; Andrews, M; Bell, AS; Chen, Y; Eller-Zarbo, C; Eshelby, N; Etienne, JB; Moore, DE; Palmer, MJ; Visser, MS; Yu, LJ; Zavadoski, WJ; Michael Gibbs, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259058&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 44574589 104109505 CHEMBL466474 ZINC40875756 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 50457366 CC(C)c1[nH]nc2c1nc(Cc1cccc(Cl)c1)[nH]c2=O InChI=1S/C15H15ClN4O/c1-8(2)12-13-14(20-19-12)15(21)18-11(17-13)7-9-4-3-5-10(16)6-9/h3-6,8H,7H2,1-2H3,(H,19,20)(H,17,18,21) UORHIBXCPUHXFY-UHFFFAOYSA-N 50259015 5-(3-chlorobenzyl)-3-isopropyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one::CHEMBL512790 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 54 ChEMBL 10.1016/j.bmcl.2009.03.024 10.7270/Q2RB74GG 19339180 Deninno, MP; Andrews, M; Bell, AS; Chen, Y; Eller-Zarbo, C; Eshelby, N; Etienne, JB; Moore, DE; Palmer, MJ; Visser, MS; Yu, LJ; Zavadoski, WJ; Michael Gibbs, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259015 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259015&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 9857583 104109490 CHEMBL512790 ZINC40401732 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 50506573 COc1cc2CCN(C)[C@H]3Cc4ccc(Oc5cc(C[C@H]6N(C)CCc7cc(OC)c(OC)c(Oc1cc23)c67)ccc5O)cc4 InChI=1S/C37H40N2O6/c1-38-14-12-24-19-32(41-3)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-31-18-23(8-11-30(31)40)17-29-35-25(13-15-39(29)2)20-34(42-4)36(43-5)37(35)45-33/h6-11,18-21,28-29,40H,12-17H2,1-5H3/t28-,29+/m0/s1 DFOCUWZXJBAUSQ-URLMMPGGSA-N 50241654 (+)-berbamine::Berbamine::CHEMBL504323 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 22000 ChEMBL 10.1021/np50075a001 10.7270/Q23X86NW 1955879 Schiff, PL TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50241654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50241654&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 275182 104098827 CHEMBL504323 C09357 ZINC30726840 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 50506574 CCOCCCCOc1ccc2C[C@H]3N(C)CCc4cc(OC)c(OC)c(Oc5cc6[C@H](Cc7ccc(Oc1c2)cc7)N(C)CCc6cc5OC)c34 InChI=1S/C43H52N2O7/c1-7-49-20-8-9-21-50-36-15-12-29-23-35-41-31(17-19-45(35)3)26-40(47-5)42(48-6)43(41)52-39-27-33-30(25-37(39)46-4)16-18-44(2)34(33)22-28-10-13-32(14-11-28)51-38(36)24-29/h10-15,24-27,34-35H,7-9,16-23H2,1-6H3/t34-,35+/m0/s1 MHFFPFLMIZYTNJ-OIDHKYIRSA-N 50293304 CHEMBL454806::O-(4-Ethoxybutyl)berbamine::O-(4-ethoxybutyl)-berbamine Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 350 ChEMBL 10.1021/np50075a001 10.7270/Q23X86NW 1955879 Schiff, PL TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50293304 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50293304&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 188375 104134855 CHEMBL454806 ZINC49841425 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 50501393 O=c1c(OCCN2CCn3c2nc2ccccc32)cn(CC2CC2)nc1-c1ccnn1-c1ccccc1 InChI=1S/C28H27N7O2/c36-27-25(37-17-16-32-14-15-34-23-9-5-4-8-22(23)30-28(32)34)19-33(18-20-10-11-20)31-26(27)24-12-13-29-35(24)21-6-2-1-3-7-21/h1-9,12-13,19-20H,10-11,14-18H2 PMQGNBOUOYQTPQ-UHFFFAOYSA-N 50180268 CHEMBL3814662 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >10000 ChEMBL 10.1016/j.bmc.2016.05.049 10.7270/Q2H9974G 27301679 Yoshikawa, M; Hitaka, T; Hasui, T; Fushimi, M; Kunitomo, J; Kokubo, H; Oki, H; Nakashima, K; Taniguchi, T Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180268 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180268&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 6DW 56654131 346549642 CHEMBL3814662 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 50554142 CCCOCCn1c2cc(ncc2nc(N2CCN(CCO)CC2)c1=O)-c1ccc(OC)nc1 InChI=1S/C24H32N6O4/c1-3-13-34-14-11-30-21-15-19(18-4-5-22(33-2)26-16-18)25-17-20(21)27-23(24(30)32)29-8-6-28(7-9-29)10-12-31/h4-5,15-17,31H,3,6-14H2,1-2H3 MNLNAGRCHNMKKJ-UHFFFAOYSA-N 50308557 3-(4-(2-hydroxyethyl)piperazin-1-yl)-1-(2-propoxyethyl)-7-(6-methoxypyridin-3-yl)pyrido[3,4-b]pyrazin-2(1H)-one::CHEMBL591501 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >2000 ChEMBL 10.1021/jm901781q 10.7270/Q2VM4CCK 20196613 Hughes, RO; Rogier, DJ; Jacobsen, EJ; Walker, JK; Macinnes, A; Bond, BR; Zhang, LL; Yu, Y; Zheng, Y; Rumsey, JM; Walgren, JL; Curtiss, SW; Fobian, YM; Heasley, SE; Cubbage, JW; Moon, JB; Brown, DL; Acker, BA; Maddux, TM; Tollefson, MB; Mischke, BV; Owen, DR; Freskos, JN; Molyneaux, JM; Benson, AG; Blevis-Bal, RM Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308557 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308557&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 24963293 104162918 CHEMBL591501 ZINC45336750 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 50536521 CCCOCCn1c2cc(ncc2nc(N[C@H]2CC[C@H](O)CC2)c1=O)-c1ccc(OC)nc1 InChI=1S/C24H31N5O4/c1-3-11-33-12-10-29-21-13-19(16-4-9-22(32-2)26-14-16)25-15-20(21)28-23(24(29)31)27-17-5-7-18(30)8-6-17/h4,9,13-15,17-18,30H,3,5-8,10-12H2,1-2H3,(H,27,28)/t17-,18- IVZATIQZZIVIQL-IYARVYRRSA-N 50300953 3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one::CHEMBL567470 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >2000 ChEMBL 10.1016/j.bmcl.2009.07.019 10.7270/Q2H41RHV 19631533 Hughes, RO; Walker, JK; Rogier, DJ; Heasley, SE; Blevis-Bal, RM; Benson, AG; Jacobsen, EJ; Cubbage, JW; Fobian, YM; Owen, DR; Freskos, JN; Molyneaux, JM; Brown, DL; Acker, BA; Maddux, TM; Tollefson, MB; Moon, JB; Mischke, BV; Rumsey, JM; Zheng, Y; MacInnes, A; Bond, BR; Yu, Y Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50300953 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50300953&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 11992634 104155314 CHEMBL567470 ZINC45245758 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 50536523 CCCOCCn1c2cc(ncc2nc(NCCN2CCOCC2)c1=O)-c1ccc(OC)nc1 InChI=1S/C24H32N6O4/c1-3-11-33-14-10-30-21-15-19(18-4-5-22(32-2)27-16-18)26-17-20(21)28-23(24(30)31)25-6-7-29-8-12-34-13-9-29/h4-5,15-17H,3,6-14H2,1-2H3,(H,25,28) OFRWMWHKNKWEHT-UHFFFAOYSA-N 50296256 7-(6-methoxypyridin-3-yl)-3-(2-morpholinoethylamino)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one::CHEMBL551052 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >2000 ChEMBL 10.1016/j.bmcl.2009.07.019 10.7270/Q2H41RHV 19631533 Hughes, RO; Walker, JK; Rogier, DJ; Heasley, SE; Blevis-Bal, RM; Benson, AG; Jacobsen, EJ; Cubbage, JW; Fobian, YM; Owen, DR; Freskos, JN; Molyneaux, JM; Brown, DL; Acker, BA; Maddux, TM; Tollefson, MB; Moon, JB; Mischke, BV; Rumsey, JM; Zheng, Y; MacInnes, A; Bond, BR; Yu, Y Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50296256 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50296256&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search TGE 11993169 104137787 CHEMBL551052 ZINC43025379 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 50701571 CCCOCCn1c2cc(nnc2c(NC2CCC(O)CC2)nc1=O)-c1ccc(OC)nc1 InChI=1S/C23H30N6O4/c1-3-11-33-12-10-29-19-13-18(15-4-9-20(32-2)24-14-15)27-28-21(19)22(26-23(29)31)25-16-5-7-17(30)8-6-16/h4,9,13-14,16-17,30H,3,5-8,10-12H2,1-2H3,(H,25,26,31) PRKYJSGLTUYCPF-UHFFFAOYSA-N 50357234 CHEMBL1916475 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >2000 ChEMBL 10.1016/j.bmcl.2011.08.106 10.7270/Q2J67HB0 21955943 Hughes, RO; Maddux, T; Joseph Rogier, D; Lu, S; Walker, JK; Jon Jacobsen, E; Rumsey, JM; Zheng, Y; Macinnes, A; Bond, BR; Han, S Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50357234 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50357234&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 57391118 136961258 CHEMBL1916475 ZINC73195563 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 50712827 COc1cc(C)c2nc3[nH]nc(C)c3c(CN3CC[C@@H](O)C3)c2c1 InChI=1S/C18H22N4O2/c1-10-6-13(24-3)7-14-15(9-22-5-4-12(23)8-22)16-11(2)20-21-18(16)19-17(10)14/h6-7,12,23H,4-5,8-9H2,1-3H3,(H,19,20,21)/t12-/m1/s1 LPMLXYRXWMPONQ-GFCCVEGCSA-N 50362033 CHEMBL1939912 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >10000 ChEMBL 10.1016/j.bmcl.2011.11.023 10.7270/Q2862GWC 22142545 Yang, SW; Smotryski, J; McElroy, WT; Tan, Z; Ho, G; Tulshian, D; Greenlee, WJ; Guzzi, M; Zhang, X; Mullins, D; Xiao, L; Hruza, A; Chan, TM; Rindgen, D; Bleickardt, C; Hodgson, R Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50362033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50362033&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 46239424 136966095 CHEMBL1939912 ZINC73157523 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 50712828 COc1cc(C)c2nc3[nH]nc(C)c3c(CN3CCOCC3)c2c1 InChI=1S/C18H22N4O2/c1-11-8-13(23-3)9-14-15(10-22-4-6-24-7-5-22)16-12(2)20-21-18(16)19-17(11)14/h8-9H,4-7,10H2,1-3H3,(H,19,20,21) UBGXXNXAPLUDQK-UHFFFAOYSA-N 50362035 CHEMBL1939914 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >10000 ChEMBL 10.1016/j.bmcl.2011.11.023 10.7270/Q2862GWC 22142545 Yang, SW; Smotryski, J; McElroy, WT; Tan, Z; Ho, G; Tulshian, D; Greenlee, WJ; Guzzi, M; Zhang, X; Mullins, D; Xiao, L; Hruza, A; Chan, TM; Rindgen, D; Bleickardt, C; Hodgson, R Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50362035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50362035&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search C1L 44243146 136966097 CHEMBL1939914 ZINC73240514 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 50712829 COc1cc(C)c2nc3[nH]nc(C)c3c(CN3CCOC(C)C3)c2c1 InChI=1S/C19H24N4O2/c1-11-7-14(24-4)8-15-16(10-23-5-6-25-12(2)9-23)17-13(3)21-22-19(17)20-18(11)15/h7-8,12H,5-6,9-10H2,1-4H3,(H,20,21,22) GRYOJSUKVCMOQH-UHFFFAOYSA-N 50362036 CHEMBL1939915 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >10000 ChEMBL 10.1016/j.bmcl.2011.11.023 10.7270/Q2862GWC 22142545 Yang, SW; Smotryski, J; McElroy, WT; Tan, Z; Ho, G; Tulshian, D; Greenlee, WJ; Guzzi, M; Zhang, X; Mullins, D; Xiao, L; Hruza, A; Chan, TM; Rindgen, D; Bleickardt, C; Hodgson, R Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50362036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50362036&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 46239425 136966098 CHEMBL1939915 ZINC73163267 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 50712830 COc1cc(C)c2nc3[nH]nc(C)c3c(CN3CCCOCC3)c2c1 InChI=1S/C19H24N4O2/c1-12-9-14(24-3)10-15-16(11-23-5-4-7-25-8-6-23)17-13(2)21-22-19(17)20-18(12)15/h9-10H,4-8,11H2,1-3H3,(H,20,21,22) IPHACPSYWWYGQN-UHFFFAOYSA-N 50362043 CHEMBL1940053 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >10000 ChEMBL 10.1016/j.bmcl.2011.11.023 10.7270/Q2862GWC 22142545 Yang, SW; Smotryski, J; McElroy, WT; Tan, Z; Ho, G; Tulshian, D; Greenlee, WJ; Guzzi, M; Zhang, X; Mullins, D; Xiao, L; Hruza, A; Chan, TM; Rindgen, D; Bleickardt, C; Hodgson, R Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50362043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50362043&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 46239428 136966105 CHEMBL1940053 ZINC72284434 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 50712831 Cc1n[nH]c2nc3c(C)cc(O)cc3c(CN3CCCOCC3)c12 InChI=1S/C18H22N4O2/c1-11-8-13(23)9-14-15(10-22-4-3-6-24-7-5-22)16-12(2)20-21-18(16)19-17(11)14/h8-9,23H,3-7,10H2,1-2H3,(H,19,20,21) RTMNFVPPLIVCTL-UHFFFAOYSA-N 50362046 CHEMBL1940056 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >10000 ChEMBL 10.1016/j.bmcl.2011.11.023 10.7270/Q2862GWC 22142545 Yang, SW; Smotryski, J; McElroy, WT; Tan, Z; Ho, G; Tulshian, D; Greenlee, WJ; Guzzi, M; Zhang, X; Mullins, D; Xiao, L; Hruza, A; Chan, TM; Rindgen, D; Bleickardt, C; Hodgson, R Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50362046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50362046&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 57403394 136966108 CHEMBL1940056 ZINC73222478 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 50712832 COCCOc1cc(C)c2nc3[nH]nc(C)c3c(CN3CCCOCC3)c2c1 InChI=1S/C21H28N4O3/c1-14-11-16(28-10-9-26-3)12-17-18(13-25-5-4-7-27-8-6-25)19-15(2)23-24-21(19)22-20(14)17/h11-12H,4-10,13H2,1-3H3,(H,22,23,24) LTIBUVNAKXWUAU-UHFFFAOYSA-N 50362047 CHEMBL1940057 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >10000 ChEMBL 10.1016/j.bmcl.2011.11.023 10.7270/Q2862GWC 22142545 Yang, SW; Smotryski, J; McElroy, WT; Tan, Z; Ho, G; Tulshian, D; Greenlee, WJ; Guzzi, M; Zhang, X; Mullins, D; Xiao, L; Hruza, A; Chan, TM; Rindgen, D; Bleickardt, C; Hodgson, R Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50362047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50362047&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 57394695 136966109 CHEMBL1940057 ZINC73164334 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 50712833 CC(C)Oc1cc(C)c2nc3[nH]nc(C)c3c(CN3CCCOCC3)c2c1 InChI=1S/C21H28N4O2/c1-13(2)27-16-10-14(3)20-17(11-16)18(12-25-6-5-8-26-9-7-25)19-15(4)23-24-21(19)22-20/h10-11,13H,5-9,12H2,1-4H3,(H,22,23,24) BXLXWGMNQZCEKI-UHFFFAOYSA-N 50362048 CHEMBL1940058 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >10000 ChEMBL 10.1016/j.bmcl.2011.11.023 10.7270/Q2862GWC 22142545 Yang, SW; Smotryski, J; McElroy, WT; Tan, Z; Ho, G; Tulshian, D; Greenlee, WJ; Guzzi, M; Zhang, X; Mullins, D; Xiao, L; Hruza, A; Chan, TM; Rindgen, D; Bleickardt, C; Hodgson, R Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50362048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50362048&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 57392948 136966110 CHEMBL1940058 ZINC73385850 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 878728 CCSc1c2c(nn1Cc1ccc(cc1)-c1ccc(F)cn1)N1CC(C)(C)N=C1N(C)C2=O InChI=1S/C24H25FN6OS/c1-5-33-22-19-20(30-14-24(2,3)27-23(30)29(4)21(19)32)28-31(22)13-15-6-8-16(9-7-15)18-11-10-17(25)12-26-18/h6-12H,5,13-14H2,1-4H3 QJODRMZIVBJSMT-UHFFFAOYSA-N 433318 3-(ethylthio)-2-(4-(5-fluoropyridin-2-yl)benzyl)-5,7,7-trimethyl-7,8-dihydro-2H-imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(5H)-one::US10561656, Example 1 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.70 US Patent 10.7270/Q2ZP48HR aid1804208 US10561656 Li, P; Zheng, H; Zhao, J; Wennogle, LP INTRA-CELLULAR THERAPIES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=433318 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=433318&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 71114389 438642251 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 50544275 FC(F)Oc1ccc(cc1OCC1CC1)C(=O)Nc1cccnc1 InChI=1S/C17H16F2N2O3/c18-17(19)24-14-6-5-12(8-15(14)23-10-11-3-4-11)16(22)21-13-2-1-7-20-9-13/h1-2,5-9,11,17H,3-4,10H2,(H,21,22) UZHICMGVAYPCLG-UHFFFAOYSA-N 50208315 CHEMBL3884224 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >100000 ChEMBL 10.1016/j.ejmech.2016.08.052 10.7270/Q29P33N6 27597413 Zhou, ZZ; Ge, BC; Zhong, QP; Huang, C; Cheng, YF; Yang, XM; Wang, HT; Xu, JP Southern Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50208315 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50208315&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 134130563 375982006 CHEMBL3884224 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 50544282 FC(F)Oc1ccc(cc1OC1CCCC1)C(=O)Nc1ccccc1Cl InChI=1S/C19H18ClF2NO3/c20-14-7-3-4-8-15(14)23-18(24)12-9-10-16(26-19(21)22)17(11-12)25-13-5-1-2-6-13/h3-4,7-11,13,19H,1-2,5-6H2,(H,23,24) IOCQLERZNMLYQW-UHFFFAOYSA-N 50208310 CHEMBL3883753 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >100000 ChEMBL 10.1016/j.ejmech.2016.08.052 10.7270/Q29P33N6 27597413 Zhou, ZZ; Ge, BC; Zhong, QP; Huang, C; Cheng, YF; Yang, XM; Wang, HT; Xu, JP Southern Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50208310 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50208310&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 134129996 375982003 CHEMBL3883753 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 50544283 FC(F)Oc1ccc(cc1OC1CCCC1)C(=O)Nc1cccnc1 InChI=1S/C18H18F2N2O3/c19-18(20)25-15-8-7-12(10-16(15)24-14-5-1-2-6-14)17(23)22-13-4-3-9-21-11-13/h3-4,7-11,14,18H,1-2,5-6H2,(H,22,23) BPBJURKFWJXNTD-UHFFFAOYSA-N 50208311 CHEMBL3885161 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >100000 ChEMBL 10.1016/j.ejmech.2016.08.052 10.7270/Q29P33N6 27597413 Zhou, ZZ; Ge, BC; Zhong, QP; Huang, C; Cheng, YF; Yang, XM; Wang, HT; Xu, JP Southern Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50208311 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50208311&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 134130328 375982004 CHEMBL3885161 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 50544292 FC(F)Oc1ccc(cc1OCC1CC1)C(=O)Nc1ccccc1Cl InChI=1S/C18H16ClF2NO3/c19-13-3-1-2-4-14(13)22-17(23)12-7-8-15(25-18(20)21)16(9-12)24-10-11-5-6-11/h1-4,7-9,11,18H,5-6,10H2,(H,22,23) FXJNCIZGQFVQLF-UHFFFAOYSA-N 50208314 CHEMBL3884788 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >100000 ChEMBL 10.1016/j.ejmech.2016.08.052 10.7270/Q29P33N6 27597413 Zhou, ZZ; Ge, BC; Zhong, QP; Huang, C; Cheng, YF; Yang, XM; Wang, HT; Xu, JP Southern Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50208314 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50208314&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 134131162 375982005 CHEMBL3884788 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 531075 CCOc1ncccc1-c1cc(NCc2cccnc2OC)c2n(nc(C)c2n1)C1COC1 InChI=1S/C24H26N6O3/c1-4-33-24-18(8-6-10-26-24)19-11-20(27-12-16-7-5-9-25-23(16)31-3)22-21(28-19)15(2)29-30(22)17-13-32-14-17/h5-11,17H,4,12-14H2,1-3H3,(H,27,28) GRFJYHDUOKDAKO-UHFFFAOYSA-N 279166 5-(2-ethoxy-3-pyridyl)-N-[(2-methoxy-3-pyridyl)methyl]-3-methyl-1-(oxetan-3-yl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 197::US10512632, Example 197::US10618913, Example S197::US10766893, Example S197::US10806718, Example 197::US11491140, Example 197::US11634416, Example 197 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 190 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279166&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273484 378160743 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 531078 CCN(C)c1ncccc1-c1cc(NCc2ccc(OC)cc2)c2n(nc(C)c2n1)C(C)C InChI=1S/C26H32N6O/c1-7-31(5)26-21(9-8-14-27-26)22-15-23(28-16-19-10-12-20(33-6)13-11-19)25-24(29-22)18(4)30-32(25)17(2)3/h8-15,17H,7,16H2,1-6H3,(H,28,29) YNHQWVLFISTQIU-UHFFFAOYSA-N 279167 5-(2-(ethyl(methyl)amino)pyridin-3-yl)-1-isopropyl-N-(4-methoxybenzyl)-3-methyl-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 198::US10512632, Example 198::US10766893, Example S198::US10806718, Example 198::US11026923, Example 198::US11491140, Example 198::US11634416, Example 198 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1100 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279167 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279167&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273483 378160744 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 531081 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(CF)c2n1)C(C)C InChI=1S/C22H26FN7O/c1-5-31-22-16(7-6-8-24-22)17-9-18(25-11-15-12-26-29(4)13-15)21-20(27-17)19(10-23)28-30(21)14(2)3/h6-9,12-14H,5,10-11H2,1-4H3,(H,25,27) CRFWOMGBISLKHY-UHFFFAOYSA-N 279168 5-(2-ethoxypyridin-3-yl)-3-(fluoromethyl)-1-isopropyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 199::US10512632, Example 199::US10618913, Example S199::US10766893, Example S199::US10806718, Example 199::US11026923, Example 199::US11491140, Example 199::US11634416, Example 199 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 7.40 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279168&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273487 378160745 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 531084 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1ocnc1C InChI=1S/C19H23N7O/c1-11(2)26-18-15(20-7-14-8-22-25(5)9-14)6-16(19-13(4)21-10-27-19)23-17(18)12(3)24-26/h6,8-11H,7H2,1-5H3,(H,20,23) JVGYDVFOXCBHRN-UHFFFAOYSA-N 279169 1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-5-(4-methyloxazol-5-yl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 200::US10512632, Example 200::US10618913, Example S200::US10766893, Example S200::US10806718, Example 200::US11026923, Example 200::US11491140, Example 200::US11634416, Example 200 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 98.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279169&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273489 378160746 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 531087 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1cccnc1N(C)C InChI=1S/C22H28N8/c1-14(2)30-21-19(24-11-16-12-25-29(6)13-16)10-18(26-20(21)15(3)27-30)17-8-7-9-23-22(17)28(4)5/h7-10,12-14H,11H2,1-6H3,(H,24,26) JWSSTJTVRAZILB-UHFFFAOYSA-N 279170 5-[2-(dimethylamino)-3-pyridyl]-1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 201::US10512632, Example 201::US10766893, Example S201::US10806718, Example 201::US11026923, Example 201::US11491140, Example 201::US11634416, Example 201 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2100 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279170&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273490 378160747 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 531090 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1nc(C)co1 InChI=1S/C19H23N7O/c1-11(2)26-18-15(20-7-14-8-21-25(5)9-14)6-16(19-22-12(3)10-27-19)23-17(18)13(4)24-26/h6,8-11H,7H2,1-5H3,(H,20,23) GNUZZRWHGHQDMA-UHFFFAOYSA-N 279171 1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-5-(4-methyloxazol-2-yl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 202::US10512632, Example 202::US10766893, Example S202::US10806718, Example 202::US11634416, Example 202 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 92.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279171&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273491 378160748 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 531093 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1nncn1C InChI=1S/C18H23N9/c1-11(2)27-17-14(19-7-13-8-21-26(5)9-13)6-15(18-23-20-10-25(18)4)22-16(17)12(3)24-27/h6,8-11H,7H2,1-5H3,(H,19,22) KAIFDCSXZCWWKF-UHFFFAOYSA-N 279172 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-(4-methyl-1,2,4-triazol-3-::US10034861, Example 203::US10512632, Example 203::US10766893, Example S203::US10806718, Example 203::US11026923, Example 203::US11491140, Example 203::US11634416, Example 203 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 410 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279172 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279172&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273492 378160749 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530490 CCOc1ncccc1-c1cc(NCc2nnc(C)o2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H25N7O2/c1-6-29-21-15(8-7-9-22-21)16-10-17(23-11-18-26-25-14(5)30-18)20-19(24-16)13(4)27-28(20)12(2)3/h7-10,12H,6,11H2,1-5H3,(H,23,24) XEBJMVLHZBRKST-UHFFFAOYSA-N 278971 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methyl-1,3,4-oxadiazol-2-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 1::US10512632, Example 1::US10618913, Example S1::US10766893, Example S1::US10806718, Example 1::US11026923, Example 1::US11491140, Example 1::US11634416, Example 1 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 18.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278971 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278971&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273299 378160560 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530493 CCOc1ncccc1-c1cc(NCc2ncc(C)s2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6OS/c1-6-29-22-16(8-7-9-23-22)17-10-18(24-12-19-25-11-14(4)30-19)21-20(26-17)15(5)27-28(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,24,26) QOYNQFLWGDTXKT-UHFFFAOYSA-N 278972 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methylthiazol-2-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 2::US10512632, Example 2::US10766893, Example S2::US10806718, Example 2::US11026923, Example 2::US11491140, Example 2::US11634416, Example 2 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.460 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278972 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278972&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273301 378160561 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530496 CCOc1ncccc1-c1cc(NCc2cc(C)on2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6O2/c1-6-29-22-17(8-7-9-23-22)18-11-19(24-12-16-10-14(4)30-27-16)21-20(25-18)15(5)26-28(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,24,25) MKELJWFWEJOZNC-UHFFFAOYSA-N 278973 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methylisoxazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 3::US10512632, Example 3::US10766893, Example S3::US10806718, Example 3::US11026923, Example 3::US11491140, Example 3::US11634416, Example 3 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.800 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278973&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273302 378160562 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530499 CCOc1ncccc1-c1cc(NCc2cnc(C)o2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6O2/c1-6-29-22-17(8-7-9-23-22)18-10-19(25-12-16-11-24-15(5)30-16)21-20(26-18)14(4)27-28(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,25,26) TWDRBTLHNZMOLP-UHFFFAOYSA-N 278974 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methyloxazol-5-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 4::US10512632, Example 4::US10766893, Example S4::US10806718, Example 4::US11026923, Example 4::US11491140, Example 4::US11634416, Example 4 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.60 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278974 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278974&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273304 378160563 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530502 CCOc1ncccc1-c1cc(NCc2cnn(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-6-30-21-16(8-7-9-22-21)17-10-18(23-11-15-12-24-28(5)27-15)20-19(25-17)14(4)26-29(20)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,23,25) RKVBYUMNPKGITG-UHFFFAOYSA-N 278975 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methyltriazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 5::US10512632, Example 5::US10766893, Example S5::US10806718, Example 5::US11026923, Example 5::US11491140, Example 5::US11634416, Example 5 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 11.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278975&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273303 378160564 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530505 CCOc1ncccc1-c1cc(NCc2cn(C)nn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-6-30-21-16(8-7-9-22-21)17-10-18(23-11-15-12-28(5)27-25-15)20-19(24-17)14(4)26-29(20)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,23,24) GZZVSCZGHCUFQG-UHFFFAOYSA-N 278976 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(1-methyltriazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 6::US10512632, Example 6::US10766893, Example S6::US10806718, Example 6::US11026923, Example 6::US11491140, Example 6::US11634416, Example 6 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4.80 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278976&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273306 378160565 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530508 CCOc1ncccc1-c1cc(NCc2cn[nH]c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H25N7O/c1-5-29-21-16(7-6-8-22-21)17-9-18(23-10-15-11-24-25-12-15)20-19(26-17)14(4)27-28(20)13(2)3/h6-9,11-13H,5,10H2,1-4H3,(H,23,26)(H,24,25) ZBYZXMQLZZULRF-UHFFFAOYSA-N 278977 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1H-pyrazol-4-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 7::US10512632, Example 7::US10766893, Example S7::US10806718, Example 7::US11026923, Example 7::US11491140, Example 7::US11634416, Example 7 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 21.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278977 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278977&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 136214891 378160566 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530511 CCOc1ncccc1-c1cc(NCc2nnn(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C20H25N9O/c1-6-30-20-14(8-7-9-21-20)15-10-16(22-11-17-24-27-28(5)26-17)19-18(23-15)13(4)25-29(19)12(2)3/h7-10,12H,6,11H2,1-5H3,(H,22,23) MMFBNAADCPOKBP-UHFFFAOYSA-N 278978 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methyltetrazol-5-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 8::US10512632, Example 8::US10766893, Example S8::US10806718, Example 8::US11491140, Example 8::US11634416, Example 8 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.90 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278978&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273308 378160567 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530514 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H27N7O/c1-6-30-22-17(8-7-9-23-22)18-10-19(24-11-16-12-25-28(5)13-16)21-20(26-18)15(4)27-29(21)14(2)3/h7-10,12-14H,6,11H2,1-5H3,(H,24,26) IGZQEXMDAKABFO-UHFFFAOYSA-N 278979 5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 9::US10512632, Example 9::US10766893, Example S9::US10806718, Example 9::US11491140, Example 9::US11634416, Example 9 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.60 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278979&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273307 378160568 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530517 CCOc1ncccc1-c1cc(NCc2cc(C)no2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6O2/c1-6-29-22-17(8-7-9-23-22)18-11-19(24-12-16-10-14(4)27-30-16)21-20(25-18)15(5)26-28(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,24,25) WAUSGEZRVANNBG-UHFFFAOYSA-N 278980 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(3-methylisoxazol-5-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 10::US10512632, Example 10::US10766893, Example S10::US10806718, Example 10::US11491140, Example 10::US11634416, Example 10 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4.10 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278980 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278980&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273310 378160569 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530520 CCOc1ncccc1-c1cc(NCc2csc(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6OS/c1-6-29-22-17(8-7-9-23-22)18-10-19(24-11-16-12-30-15(5)25-16)21-20(26-18)14(4)27-28(21)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,24,26) YDCVOKZJZPJMKM-UHFFFAOYSA-N 278981 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methylthiazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 11::US10512632, Example 11::US10766893, Example S11::US10806718, Example 11::US11491140, Example 11::US11634416, Example 11 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 9.60 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278981&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273309 378160570 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530523 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C1CC1 InChI=1S/C22H25N7O/c1-4-30-22-17(6-5-9-23-22)18-10-19(24-11-15-12-25-28(3)13-15)21-20(26-18)14(2)27-29(21)16-7-8-16/h5-6,9-10,12-13,16H,4,7-8,11H2,1-3H3,(H,24,26) SVNBZNOJEMDHHP-UHFFFAOYSA-N 278982 1-cyclopropyl-5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 12::US10512632, Example 12::US10618913, Example S12::US10766893, Example S12::US10806718, Example 12::US11026923, Example 12::US11491140, Example 12 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 200 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278982&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273311 378160571 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530526 CCCn1ncc2nc(cc(NCc3cnn(C)c3)c12)-c1cccnc1OCC InChI=1S/C21H25N7O/c1-4-9-28-20-18(23-11-15-12-24-27(3)14-15)10-17(26-19(20)13-25-28)16-7-6-8-22-21(16)29-5-2/h6-8,10,12-14H,4-5,9,11H2,1-3H3,(H,23,26) VBBYLKGVLRZVDT-UHFFFAOYSA-N 278983 5-(2-ethoxy-3-pyridyl)-N-[(1-methylpyrazol-4-yl)methyl]-1-propyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 13::US10512632, Example 13::US10618913, Example S13::US10766893, Example S13::US10806718, Example 13::US11026923, Example 13::US11491140, Example 13::US11634416, Example 13 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 90.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278983 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278983&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273312 378160572 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530529 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(ncc2n1)C1COC1 InChI=1S/C21H23N7O2/c1-3-30-21-16(5-4-6-22-21)17-7-18(23-8-14-9-24-27(2)11-14)20-19(26-17)10-25-28(20)15-12-29-13-15/h4-7,9-11,15H,3,8,12-13H2,1-2H3,(H,23,26) BRAWZTIBDHEBNS-UHFFFAOYSA-N 278984 5-(2-ethoxypyridin-3-yl)-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1-(oxetan-3-yl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 14::US10512632, Example 14::US10618913, Example S14::US10766893, Example S14::US10806718, Example 14::US11026923, Example 14::US11491140, Example 14::US11634416, Example 14 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 450 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278984 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278984&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273313 378160573 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530532 CCOc1ncccc1-c1cc(NC(C)c2cnn(C)c2)c2n(C)ncc2n1 InChI=1S/C20H23N7O/c1-5-28-20-15(7-6-8-21-20)16-9-17(19-18(25-16)11-23-27(19)4)24-13(2)14-10-22-26(3)12-14/h6-13H,5H2,1-4H3,(H,24,25) PRZKTPKTSVRPRD-UHFFFAOYSA-N 278985 5-(2-ethoxypyridin-3-yl)-1-methyl-N-(1-(1-methyl-1H-pyrazol-4-yl)ethyl)-1H-pyrazolo[4,3-b]pyridin-7-amine (racemic)::US10034861, Example 15::US10766893, Example S15::US10806718, Example 15::US11026923, Example 15::US11491140, Example 15 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 820 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278985 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278985&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273314 378160574 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530535 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(C)ncc2n1 InChI=1S/C19H21N7O/c1-4-27-19-14(6-5-7-20-19)15-8-16(18-17(24-15)11-23-26(18)3)21-9-13-10-22-25(2)12-13/h5-8,10-12H,4,9H2,1-3H3,(H,21,24) IHPVHEUBCHVJEQ-UHFFFAOYSA-N 278986 5-(2-ethoxypyridin-3-yl)-1-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 16::US10512632, Example 16::US10766893, Example S16::US10806718, Example 16::US11026923, Example 16::US11491140, Example 16 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 670 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278986&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273315 378160575 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530538 CCOc1ncccc1-c1cc(NCc2nccn2C)c2n(ncc2n1)C(C)C InChI=1S/C21H25N7O/c1-5-29-21-15(7-6-8-23-21)16-11-17(24-13-19-22-9-10-27(19)4)20-18(26-16)12-25-28(20)14(2)3/h6-12,14H,5,13H2,1-4H3,(H,24,26) XRIYYPDCPKIHRW-UHFFFAOYSA-N 278987 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimidazol-2-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 17::US10512632, Example 17::US10618913, Example S17::US10766893, Example S17::US10806718, Example 17::US11026923, Example 17::US11491140, Example 17::US11634416, Example 17 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 700 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278987 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278987&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273316 378160576 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530541 CCOc1ncccc1-c1cc(NCc2ccnn2C)c2n(ncc2n1)C(C)C InChI=1S/C21H25N7O/c1-5-29-21-16(7-6-9-22-21)17-11-18(23-12-15-8-10-24-27(15)4)20-19(26-17)13-25-28(20)14(2)3/h6-11,13-14H,5,12H2,1-4H3,(H,23,26) ARZYUJKMHFQSRW-UHFFFAOYSA-N 278988 5-(2-ethoxypyridin-3-yl)-1-isopropyl-N-((1-methyl-1H-pyrazol-5-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 18::US10512632, Example 18::US10766893, Example S18::US10806718, Example 18::US11026923, Example 18::US11491140, Example 18::US11634416, Example 18 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 450 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278988&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273317 378160577 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530544 CCOc1ncccc1-c1cc(NCc2ccn(C)n2)c2n(ncc2n1)C(C)C InChI=1S/C21H25N7O/c1-5-29-21-16(7-6-9-22-21)17-11-18(23-12-15-8-10-27(4)26-15)20-19(25-17)13-24-28(20)14(2)3/h6-11,13-14H,5,12H2,1-4H3,(H,23,25) KZFYUJZMDBTCDC-UHFFFAOYSA-N 278989 5-(2-ethoxypyridin-3-yl)-1-isopropyl-N-((1-methyl-1H-pyrazol-3-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 19::US10512632, Example 19::US10766893, Example S19::US10806718, Example 19::US11026923, Example 19::US11491140, Example 19::US11634416, Example 19 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 66.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278989 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278989&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273318 378160578 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530547 CCOc1ncccc1-c1cc(NCc2nccs2)c2n(ncc2n1)C(C)C InChI=1S/C20H22N6OS/c1-4-27-20-14(6-5-7-22-20)15-10-16(23-12-18-21-8-9-28-18)19-17(25-15)11-24-26(19)13(2)3/h5-11,13H,4,12H2,1-3H3,(H,23,25) ICTYYJZHJNSZFG-UHFFFAOYSA-N 278990 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-(thiazol-2-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 20::US10512632, Example 20::US10766893, Example S20::US10806718, Example 20::US11026923, Example 20::US11491140, Example 20::US11634416, Example 20 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 520 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278990&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273319 378160579 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530550 CCOc1ncccc1-c1cc(NCc2cn(C)cn2)c2n(ncc2n1)C(C)C InChI=1S/C21H25N7O/c1-5-29-21-16(7-6-8-22-21)17-9-18(23-10-15-12-27(4)13-24-15)20-19(26-17)11-25-28(20)14(2)3/h6-9,11-14H,5,10H2,1-4H3,(H,23,26) GPZPPQFWVLHHBU-UHFFFAOYSA-N 278991 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimidazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 21::US10512632, Example 21::US10766893, Example S21::US10806718, Example 21::US11026923, Example 21::US11491140, Example 21::US11634416, Example 21 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.90 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278991&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273320 378160580 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530553 CCOc1ncccc1-c1cc(NCc2ccncc2)c2n(ncc2n1)C(C)C InChI=1S/C22H24N6O/c1-4-29-22-17(6-5-9-24-22)18-12-19(25-13-16-7-10-23-11-8-16)21-20(27-18)14-26-28(21)15(2)3/h5-12,14-15H,4,13H2,1-3H3,(H,25,27) HEERUKANWGHTOL-UHFFFAOYSA-N 278992 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-(4-pyridylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 22::US10512632, Example 22::US10766893, Example S22::US10806718, Example 22::US11026923, Example 22::US11491140, Example 22::US11634416, Example 22 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 250 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278992&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273322 378160581 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530556 CCOc1ncccc1-c1cc(NCc2cccc(C)c2)c2n(ncc2n1)C(C)C InChI=1S/C24H27N5O/c1-5-30-24-19(10-7-11-25-24)20-13-21(26-14-18-9-6-8-17(4)12-18)23-22(28-20)15-27-29(23)16(2)3/h6-13,15-16H,5,14H2,1-4H3,(H,26,28) NOGPVEPEDSPNHF-UHFFFAOYSA-N 278993 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-(m-tolylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 23::US10512632, Example 23::US10618913, Example S23::US10766893, Example S23::US10806718, Example 23::US11026923, Example 23::US11491140, Example 23::US11634416, Example 23 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 240 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278993&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273321 378160582 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530559 CCOc1ncccc1-c1cc(NCc2ccc(C)cc2)c2n(ncc2n1)C(C)C InChI=1S/C24H27N5O/c1-5-30-24-19(7-6-12-25-24)20-13-21(26-14-18-10-8-17(4)9-11-18)23-22(28-20)15-27-29(23)16(2)3/h6-13,15-16H,5,14H2,1-4H3,(H,26,28) KLXXAXDPPNWJOU-UHFFFAOYSA-N 278994 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-(p-tolylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 24::US10512632, Example 24::US10766893, Example S24::US10806718, Example 24::US11026923, Example 24::US11491140, Example 24::US11634416, Example 24 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 380 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278994&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273323 378160583 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530562 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(ncc2n1)C(C)C InChI=1S/C21H25N7O/c1-5-29-21-16(7-6-8-22-21)17-9-18(23-10-15-11-24-27(4)13-15)20-19(26-17)12-25-28(20)14(2)3/h6-9,11-14H,5,10H2,1-4H3,(H,23,26) PLERDTYSXFBCOL-UHFFFAOYSA-N 278995 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 25::US10512632, Example 25::US10766893, Example S25::US10806718, Example 25::US11026923, Example 25::US11491140, Example 25::US11634416, Example 25 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 56.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278995&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273324 378160584 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530565 CCOc1ccncc1-c1cc(NCc2cnn(C)c2)c2n(CC)ncc2n1 InChI=1S/C20H23N7O/c1-4-27-20-17(22-9-14-10-23-26(3)13-14)8-16(25-18(20)12-24-27)15-11-21-7-6-19(15)28-5-2/h6-8,10-13H,4-5,9H2,1-3H3,(H,22,25) OKGINEWBFLWKOX-UHFFFAOYSA-N 278996 5-(2-ethoxy-3-pyridyl)-1-ethyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 26 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 140 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278996 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278996&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273325 378160585 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530568 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C1COC1 InChI=1S/C22H25N7O2/c1-4-31-22-17(6-5-7-23-22)18-8-19(24-9-15-10-25-28(3)11-15)21-20(26-18)14(2)27-29(21)16-12-30-13-16/h5-8,10-11,16H,4,9,12-13H2,1-3H3,(H,24,26) HKTCICUQHUTDJM-UHFFFAOYSA-N 278997 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-1-(oxetan-3-yl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 27::US10512632, Example 27::US10766893, Example S27::US10806718, Example 27::US11026923, Example 27::US11491140, Example 27::US11634416, Example 27 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 94.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278997 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278997&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273326 378160586 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530571 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(C)nc(C)c2n1 InChI=1S/C20H23N7O/c1-5-28-20-15(7-6-8-21-20)16-9-17(22-10-14-11-23-26(3)12-14)19-18(24-16)13(2)25-27(19)4/h6-9,11-12H,5,10H2,1-4H3,(H,22,24) GGQMHLLGYDUHDQ-UHFFFAOYSA-N 278998 5-(2-ethoxy-3-pyridyl)-1,3-dimethyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 28::US10512632, Example 28::US10618913, Example S28::US10766893, Example S28::US10806718, Example 28::US11026923, Example 28::US11491140, Example 28::US11634416, Example 28 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 550 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278998 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278998&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273327 378160587 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530574 CCOc1ncccc1-c1cc(NCc2nc(C)cs2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6OS/c1-6-29-22-16(8-7-9-23-22)17-10-18(24-11-19-25-14(4)12-30-19)21-20(26-17)15(5)27-28(21)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,24,26) WFSFSRAGPIZNCC-UHFFFAOYSA-N 278999 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(4-methylthiazol-2-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 29::US10512632, Example 29::US10618913, Example S162::US10766893, Example S29::US10806718, Example 29::US11026923, Example 29::US11491140, Example 29::US11634416, Example 29 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 27.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278999 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278999&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273328 378160588 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530577 CCOc1ncccc1-c1cc(NCc2nc(C)no2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H25N7O2/c1-6-29-21-15(8-7-9-22-21)16-10-17(23-11-18-24-14(5)27-30-18)20-19(25-16)13(4)26-28(20)12(2)3/h7-10,12H,6,11H2,1-5H3,(H,23,25) ZPMKSBYSMXCOIZ-UHFFFAOYSA-N 279000 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(3-methyl-1,2,4-oxadiazol-5-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 30::US10512632, Example 30::US10766893, Example S30::US10806718, Example 30::US11026923, Example 30::US11491140, Example 30::US11634416, Example 30 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 15.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279000 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279000&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273329 378160589 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530580 CCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-6-30-21-15(8-7-9-22-21)16-10-17(23-11-18-24-12-28(5)27-18)20-19(25-16)14(4)26-29(20)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,23,25) CJOUFKUESMXTOX-UHFFFAOYSA-N 279001 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 161::US10034861, Example 31::US10512632, Example 31::US10766893, Example S31::US10806718, Example 31::US11026923, Example 31::US11491140, Example 31::US11634416, Example 31 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.20 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279001 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279001&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273330 378160590 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530583 CCOc1ncccc1-c1cc(NCc2cnc(C)s2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6OS/c1-6-29-22-17(8-7-9-23-22)18-10-19(25-12-16-11-24-15(5)30-16)21-20(26-18)14(4)27-28(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,25,26) UJFBEAPRUYBIKE-UHFFFAOYSA-N 279002 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methylthiazol-5-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 32::US10512632, Example 32::US10766893, Example S32::US10806718, Example 32::US11026923, Example 32::US11491140, Example 32::US11634416, Example 32 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4.60 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279002&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273331 378160591 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530586 CCOc1ncccc1-c1cc(NCc2nnc(C)s2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H25N7OS/c1-6-29-21-15(8-7-9-22-21)16-10-17(23-11-18-26-25-14(5)30-18)20-19(24-16)13(4)27-28(20)12(2)3/h7-10,12H,6,11H2,1-5H3,(H,23,24) XQUFGMNXDPCXMM-UHFFFAOYSA-N 279003 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methyl-1,3,4-thiadiazol-2-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 33::US10512632, Example 33::US10766893, Example S33::US10806718, Example 33::US11026923, Example 33::US11491140, Example 33::US11634416, Example 33 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.60 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279003 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279003&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273332 378160592 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530589 CCOc1ncccc1-c1cc(NCc2csc(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N5OS/c1-6-29-23-18(8-7-9-24-23)19-11-20(25-12-17-10-15(4)30-13-17)22-21(26-19)16(5)27-28(22)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,25,26) VNCLCBKVWWHCAF-UHFFFAOYSA-N 279004 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methyl-3-thienyl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 34::US10512632, Example 34::US10766893, Example S34::US10806718, Example 34::US11026923, Example 34::US11491140, Example 34::US11634416, Example 34 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.10 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279004 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279004&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273333 378160593 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530592 CCOc1ncccc1-c1cc(NCc2cc(C)cs2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N5OS/c1-6-29-23-18(8-7-9-24-23)19-11-20(25-12-17-10-15(4)13-30-17)22-21(26-19)16(5)27-28(22)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,25,26) DHODKXCCORNYHA-UHFFFAOYSA-N 279005 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(4-methyl-2-thienyl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 35::US10512632, Example 35::US10766893, Example S35::US10806718, Example 35::US11026923, Example 35::US11491140, Example 35::US11634416, Example 35 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 7.30 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279005 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279005&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273334 378160594 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530595 CCOc1ncccc1-c1cc(NCc2ccc(C)s2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N5OS/c1-6-29-23-18(8-7-11-24-23)19-12-20(25-13-17-10-9-15(4)30-17)22-21(26-19)16(5)27-28(22)14(2)3/h7-12,14H,6,13H2,1-5H3,(H,25,26) MXNGXYQZCMFPJD-UHFFFAOYSA-N 279006 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methyl-2-thienyl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 36::US10512632, Example 36::US10766893, Example S36::US10806718, Example 36::US11026923, Example 36::US11491140, Example 36::US11634416, Example 36 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 24.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279006&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273337 378160595 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530598 CCOc1ncccc1-c1cc(NCc2coc(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6O2/c1-6-29-22-17(8-7-9-23-22)18-10-19(24-11-16-12-30-15(5)25-16)21-20(26-18)14(4)27-28(21)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,24,26) VZTGUNQMZSOPTA-UHFFFAOYSA-N 279007 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methyloxazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 37::US10512632, Example 37::US10766893, Example S37::US10806718, Example 37::US11026923, Example 37::US11491140, Example 37::US11634416, Example 37 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 5.90 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279007 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279007&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273335 378160596 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530601 CCOc1ncccc1-c1cc(NCc2ncc(C)o2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6O2/c1-6-29-22-16(8-7-9-23-22)17-10-18(24-12-19-25-11-14(4)30-19)21-20(26-17)15(5)27-28(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,24,26) IGMSFVIKHQRGSP-UHFFFAOYSA-N 279008 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methyloxazol-2-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 38::US10512632, Example 38::US10766893, Example S38::US10806718, Example 38::US11026923, Example 38::US11491140, Example 38::US11634416, Example 38 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.10 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279008 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279008&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273338 378160597 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530604 CCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H25N7O/c1-5-29-21-16(7-6-9-22-21)17-11-18(23-12-15-8-10-24-26-15)20-19(25-17)14(4)27-28(20)13(2)3/h6-11,13H,5,12H2,1-4H3,(H,23,25)(H,24,26) UOWVOVPKNPTQQH-UHFFFAOYSA-N 279009 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 39::US10512632, Example 39::US10766893, Example S39::US10806718, Example 39::US11026923, Example 39::US11491140, Example 39::US11634416, Example 39 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.10 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279009 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279009&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273340 378160598 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530607 CCOc1ncccc1-c1cc(NCc2c[nH]cn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H25N7O/c1-5-29-21-16(7-6-8-23-21)17-9-18(24-11-15-10-22-12-25-15)20-19(26-17)14(4)27-28(20)13(2)3/h6-10,12-13H,5,11H2,1-4H3,(H,22,25)(H,24,26) IQIUSKXHLPBBOV-UHFFFAOYSA-N 279010 5-(2-ethoxy-3-pyridyl)-N-(1H-imidazol-4-ylmethyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 40::US10512632, Example 40::US10766893, Example S40::US10806718, Example 40::US11026923, Example 40::US11491140, Example 40::US11634416, Example 40 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 14.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279010 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279010&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273339 378160599 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530610 CCOc1ncccc1-c1cc(NCc2ccccc2)c2n(ncc2n1)C(C)C InChI=1S/C23H25N5O/c1-4-29-23-18(11-8-12-24-23)19-13-20(25-14-17-9-6-5-7-10-17)22-21(27-19)15-26-28(22)16(2)3/h5-13,15-16H,4,14H2,1-3H3,(H,25,27) CAHURFTWFHHOPU-UHFFFAOYSA-N 279011 N-benzyl-5-(2-ethoxy-3-pyridyl)-1-isopropyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 41::US10512632, Example 41::US10618913, Example S41::US10766893, Example S41::US10806718, Example 41::US11026923, Example 41::US11634416, Example 41 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 500 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279011 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279011&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273336 378160600 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530613 CCOc1ncccc1-c1cc(NCc2cc(C)no2)c2n(ncc2n1)C(C)C InChI=1S/C21H24N6O2/c1-5-28-21-16(7-6-8-22-21)17-10-18(23-11-15-9-14(4)26-29-15)20-19(25-17)12-24-27(20)13(2)3/h6-10,12-13H,5,11H2,1-4H3,(H,23,25) ZGFGKVRUAVJQMR-UHFFFAOYSA-N 279012 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(3-methylisoxazol-5-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 42::US10512632, Example 42::US10766893, Example S42::US10806718, Example 42::US11026923, Example 42::US11634416, Example 42 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 82.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279012&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273341 378160601 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530616 CCOc1ncccc1-c1cc(NCc2noc(C)n2)c2n(ncc2n1)C(C)C InChI=1S/C20H23N7O2/c1-5-28-20-14(7-6-8-21-20)15-9-16(22-11-18-24-13(4)29-26-18)19-17(25-15)10-23-27(19)12(2)3/h6-10,12H,5,11H2,1-4H3,(H,22,25) SDTZIRBETDMBLS-UHFFFAOYSA-N 279013 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 43::US10512632, Example 43::US10766893, Example S43::US10806718, Example 43::US11026923, Example 43::US11634416, Example 43 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 30.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279013&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273344 378160602 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530619 CCOc1ncccc1-c1cc(NCc2cc(C)n(C)n2)c2n(ncc2n1)C(C)C InChI=1S/C22H27N7O/c1-6-30-22-17(8-7-9-23-22)18-11-19(24-12-16-10-15(4)28(5)27-16)21-20(26-18)13-25-29(21)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,24,26) RWTZKAWRGHZQKR-UHFFFAOYSA-N 279014 N-[(1,5-dimethylpyrazol-3-yl)methyl]-5-(2-ethoxy-3-pyridyl)-1-isopropyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 44::US10512632, Example 44::US10766893, Example S44::US10806718, Example 44::US11026923, Example 44::US11634416, Example 44 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 19.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279014 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279014&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273342 378160603 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530622 CCOc1ncccc1-c1cc(NCc2ccc(=O)n(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(8-7-11-25-24)19-12-20(26-13-17-9-10-21(31)29(5)14-17)23-22(27-19)16(4)28-30(23)15(2)3/h7-12,14-15H,6,13H2,1-5H3,(H,26,27) IFSZKCSGKSFXTM-UHFFFAOYSA-N 279015 3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4-yl)methyl)amino)-1H-pyrazolo[4,3-b]pyridin-5-yl)-1-methylpyridin-2(1H)-one::US10034861, Example 45::US10512632, Example 45::US10806718, Example 45::US11026923, Example 45::US11491140, Example 45::US11634416, Example 45 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.00 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279015 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279015&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273343 378160604 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530625 CCOc1ncccc1-c1cc(NCc2c[nH]c(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H27N7O/c1-6-30-22-17(8-7-9-23-22)18-10-19(25-12-16-11-24-15(5)26-16)21-20(27-18)14(4)28-29(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,24,26)(H,25,27) OESORFJHOJQXKR-UHFFFAOYSA-N 279016 5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((2-methyl-1H-imidazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 46::US10512632, Example 46::US10766893, Example S46::US10806718, Example 46::US11026923, Example 46::US11491140, Example 46::US11634416, Example 46 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 5.00 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279016&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273345 378160605 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530628 CCOc1ncccc1-c1cc(NCc2cc(C)[nH]n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H27N7O/c1-6-30-22-17(8-7-9-23-22)18-11-19(24-12-16-10-14(4)26-27-16)21-20(25-18)15(5)28-29(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,24,25)(H,26,27) BKIZQOUWXXJIIE-UHFFFAOYSA-N 279017 5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((5-methyl-1H-pyrazol-3-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 47::US10512632, Example 47::US10766893, Example S54::US10806718, Example 47::US11026923, Example 47::US11491140, Example 47::US11634416, Example 47 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.60 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279017&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273346 378160606 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530631 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(CC)nc(C)c2n1 InChI=1S/C21H25N7O/c1-5-28-20-18(23-11-15-12-24-27(4)13-15)10-17(25-19(20)14(3)26-28)16-8-7-9-22-21(16)29-6-2/h7-10,12-13H,5-6,11H2,1-4H3,(H,23,25) ALQSQGPOANFHOP-UHFFFAOYSA-N 279018 5-(2-ethoxypyridin-3-yl)-1-ethyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 48::US10512632, Example 48::US10618913, Example S48::US10766893, Example S48::US10806718, Example 48::US11026923, Example 48::US11491140, Example 48::US11634416, Example 48 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 38.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279018&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273347 378160607 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530634 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1cccn(C)c1=O InChI=1S/C21H25N7O/c1-13(2)28-20-18(22-10-15-11-23-27(5)12-15)9-17(24-19(20)14(3)25-28)16-7-6-8-26(4)21(16)29/h6-9,11-13H,10H2,1-5H3,(H,22,24) MRQVRXHGMURIIP-UHFFFAOYSA-N 279019 3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4-yl)methyl)amino)-1H-pyrazolo[4,3-b]pyridin-5-yl)-1-methylpyridin-2(1H)-one::US10034861, Example 49::US10512632, Example 49::US10766893, Example S49::US10806718, Example 49::US11026923, Example 49::US11491140, Example 49::US11634416, Example 49 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 170 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279019 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279019&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273348 378160608 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530637 CCOc1ncccc1-c1cc(NCc2nc(C)co2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6O2/c1-6-29-22-16(8-7-9-23-22)17-10-18(24-11-19-25-14(4)12-30-19)21-20(26-17)15(5)27-28(21)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,24,26) LWOWQQZYEXAZTD-UHFFFAOYSA-N 279020 5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((4-methyloxazol-2-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine 2,2,2-trifluoroacetate::US10034861, Example 50::US10512632, Example 50::US10766893, Example S50::US10806718, Example 50::US11026923, Example 50::US11491140, Example 50::US11634416, Example 50 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 9.00 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279020 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279020&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273350 378160609 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530640 CCOc1ncccc1-c1cc(NCc2cn(C)c(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H29N7O/c1-7-31-23-18(9-8-10-24-23)19-11-20(25-12-17-13-29(6)16(5)26-17)22-21(27-19)15(4)28-30(22)14(2)3/h8-11,13-14H,7,12H2,1-6H3,(H,25,27) RIBLUNUCLUPFGL-UHFFFAOYSA-N 279021 N-((1,2-dimethyl-1H-imidazol-4-yl)methyl)-5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-1H-pyrazolo[4,3-b]pyridin-7-amine 2,2,2-trifluoroacetate::US10034861, Example 51::US10512632, Example 51::US10766893, Example S51::US10806718, Example 51::US11026923, Example 51::US11491140, Example 51::US11634416, Example 51 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 53.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279021 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279021&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273354 378160610 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530643 CCOc1ncccc1-c1cc(NCc2noc(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H25N7O2/c1-6-29-21-15(8-7-9-22-21)16-10-17(23-11-18-24-14(5)30-27-18)20-19(25-16)13(4)26-28(20)12(2)3/h7-10,12H,6,11H2,1-5H3,(H,23,25) GALBTAGDVOLYTK-UHFFFAOYSA-N 279022 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 52::US10512632, Example 52::US10766893, Example S52::US10806718, Example 52::US11026923, Example 52::US11491140, Example 52 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.90 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279022 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279022&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273351 378160611 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530646 CCOc1ncccc1-c1cc(NCc2ncon2)c2n(nc(C)c2n1)C(C)C InChI=1S/C20H23N7O2/c1-5-28-20-14(7-6-8-21-20)15-9-16(22-10-17-23-11-29-26-17)19-18(24-15)13(4)25-27(19)12(2)3/h6-9,11-12H,5,10H2,1-4H3,(H,22,24) HUAHNRHWFFYRAT-UHFFFAOYSA-N 279023 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1,2,4-oxadiazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 53::US10512632, Example 53::US10766893, Example S53::US10806718, Example 53::US11026923, Example 53::US11491140, Example 53::US11634416, Example 53 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 9.30 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279023&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273357 378160612 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530649 CCOc1ncccc1-c1cc(NCc2cc(C)n(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H29N7O/c1-7-31-23-18(9-8-10-24-23)19-12-20(25-13-17-11-15(4)29(6)28-17)22-21(26-19)16(5)27-30(22)14(2)3/h8-12,14H,7,13H2,1-6H3,(H,25,26) LOSBPLVFUGTAOA-UHFFFAOYSA-N 279024 N-[(1,5-dimethylpyrazol-3-yl)methyl]-5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 54::US10512632, Example 54::US10806718, Example 54::US11026923, Example 54::US11491140, Example 54::US11634416, Example 54 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.390 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279024 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279024&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273352 378160613 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530652 CCOc1ncccc1-c1cc(NCc2n[nH]c(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-6-30-21-15(8-7-9-22-21)16-10-17(23-11-18-24-14(5)26-27-18)20-19(25-16)13(4)28-29(20)12(2)3/h7-10,12H,6,11H2,1-5H3,(H,23,25)(H,24,26,27) QVFBWQCMGPADBC-UHFFFAOYSA-N 279025 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methyl-1H-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 55::US10512632, Example 55::US10766893, Example S55::US10806718, Example 55::US11026923, Example 55::US11491140, Example 55::US11634416, Example 55 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 3.40 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279025&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273353 378160614 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530655 CCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(ncc2n1)C(C)C InChI=1S/C20H24N8O/c1-5-29-20-14(7-6-8-21-20)15-9-16(22-11-18-23-12-27(4)26-18)19-17(25-15)10-24-28(19)13(2)3/h6-10,12-13H,5,11H2,1-4H3,(H,22,25) LBAWYUCYPDZBSF-UHFFFAOYSA-N 279026 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 56::US10512632, Example 56::US10766893, Example S56::US10806718, Example 56::US11026923, Example 56::US11491140, Example 56::US11634416, Example 56 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 16.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279026&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273358 378160615 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530658 CCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(ncc2n1)C(C)C InChI=1S/C20H23N7O/c1-4-28-20-15(6-5-8-21-20)16-10-17(22-11-14-7-9-23-26-14)19-18(25-16)12-24-27(19)13(2)3/h5-10,12-13H,4,11H2,1-3H3,(H,22,25)(H,23,26) RZEYZCLEVMBHDS-UHFFFAOYSA-N 279027 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 57::US10512632, Example 57::US10766893, Example S57::US10806718, Example 57::US11026923, Example 57::US11491140, Example 57::US11634416, Example 57 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 98.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279027&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273355 378160616 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530661 CCOc1ncccc1-c1cc(NCc2cn(C)cn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H27N7O/c1-6-30-22-17(8-7-9-23-22)18-10-19(24-11-16-12-28(5)13-25-16)21-20(26-18)15(4)27-29(21)14(2)3/h7-10,12-14H,6,11H2,1-5H3,(H,24,26) LRTCNZDFQQIFPH-UHFFFAOYSA-N 279028 5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((1-methyl-1H-imidazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine 2,2,2-trifluoroacetate::US10034861, Example 58::US10512632, Example 58::US10766893, Example S58::US10806718, Example 58::US11026923, Example 58::US11491140, Example 58::US11634416, Example 58 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.10 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279028&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273360 378160617 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530664 CCOc1ncccc1-c1cc(NCc2nnco2)c2n(nc(C)c2n1)C(C)C InChI=1S/C20H23N7O2/c1-5-28-20-14(7-6-8-21-20)15-9-16(22-10-17-25-23-11-29-17)19-18(24-15)13(4)26-27(19)12(2)3/h6-9,11-12H,5,10H2,1-4H3,(H,22,24) AHFKEZBAZQXEDY-UHFFFAOYSA-N 279029 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1,3,4-oxadiazol-2-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 59::US10512632, Example 59::US10766893, Example S59::US10806718, Example 59::US11026923, Example 59::US11491140, Example 59::US11634416, Example 59 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 55.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279029&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273356 378160618 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530667 CCOc1ncccc1-c1cc(NCc2ccn(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H27N7O/c1-6-30-22-17(8-7-10-23-22)18-12-19(24-13-16-9-11-28(5)27-16)21-20(25-18)15(4)26-29(21)14(2)3/h7-12,14H,6,13H2,1-5H3,(H,24,25) FXMRNOZDEMMBMY-UHFFFAOYSA-N 279030 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(1-methylpyrazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 60::US10512632, Example 60::US10766893, Example S60::US10806718, Example 60::US11491140, Example 60::US11634416, Example 60 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 6.50 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279030&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273369 378160619 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530670 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1cn(C)nc1C InChI=1S/C20H26N8/c1-12(2)28-20-18(21-8-15-9-22-26(5)10-15)7-17(23-19(20)14(4)25-28)16-11-27(6)24-13(16)3/h7,9-12H,8H2,1-6H3,(H,21,23) SZOKENQFAYLAJE-UHFFFAOYSA-N 279031 5-(1,3-dimethylpyrazol-4-yl)-1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 61::US10512632, Example 61::US10618913, Example S61::US10766893, Example S61::US10806718, Example 61::US11491140, Example 61::US11634416, Example 61 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 550 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279031&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273370 378160620 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530673 COc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H25N7O/c1-13(2)28-20-18(23-10-15-11-24-27(4)12-15)9-17(25-19(20)14(3)26-28)16-7-6-8-22-21(16)29-5/h6-9,11-13H,10H2,1-5H3,(H,23,25) NDQZTZXQHDYXCS-UHFFFAOYSA-N 279032 1-isopropyl-5-(2-methoxy-3-pyridyl)-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 62::US10512632, Example 62::US10766893, Example S62::US10806718, Example 62::US11491140, Example 62::US11634416, Example 62 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 16.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279032&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273362 378160621 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530676 COc1ccccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6O/c1-14(2)28-22-19(23-11-16-12-24-27(4)13-16)10-18(25-21(22)15(3)26-28)17-8-6-7-9-20(17)29-5/h6-10,12-14H,11H2,1-5H3,(H,23,25) KTDTYSKLFCIVHF-UHFFFAOYSA-N 279033 1-isopropyl-5-(2-methoxyphenyl)-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 63::US10512632, Example 63::US10766893, Example S63::US10806718, Example 63::US11491140, Example 63::US11634416, Example 63 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 64.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279033&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273359 378160622 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530679 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1ccccc1 InChI=1S/C21H24N6/c1-14(2)27-21-19(22-11-16-12-23-26(4)13-16)10-18(17-8-6-5-7-9-17)24-20(21)15(3)25-27/h5-10,12-14H,11H2,1-4H3,(H,22,24) JFQFIBIPASGZMG-UHFFFAOYSA-N 279034 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-phenyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 64::US10512632, Example 64::US10766893, Example S64::US10806718, Example 64::US11491140, Example 64::US11634416, Example 64 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 52.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279034&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273365 378160623 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530682 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1ccsc1C InChI=1S/C20H24N6S/c1-12(2)26-20-18(21-9-15-10-22-25(5)11-15)8-17(16-6-7-27-14(16)4)23-19(20)13(3)24-26/h6-8,10-12H,9H2,1-5H3,(H,21,23) OOGMCENLMFETDO-UHFFFAOYSA-N 279035 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-(2-methyl-3-thienyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 65::US10512632, Example 65::US10766893, Example S65::US10806718, Example 65::US11491140, Example 65::US11634416, Example 65 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 7.90 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279035&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273363 378160624 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530685 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1cnn(C)c1C InChI=1S/C20H26N8/c1-12(2)28-20-18(21-8-15-9-22-26(5)11-15)7-17(24-19(20)13(3)25-28)16-10-23-27(6)14(16)4/h7,9-12H,8H2,1-6H3,(H,21,24) IOBLPVSVJNVETM-UHFFFAOYSA-N 279036 5-(1,5-dimethylpyrazol-4-yl)-1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 66::US10512632, Example 66::US10766893, Example S66::US10806718, Example 66::US11491140, Example 66::US11634416, Example 66 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 210 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279036&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273361 378160625 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530688 CCOc1ncccc1-c1cc(NCc2ccn(C)n2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C23H29N7O/c1-6-15(3)30-22-20(25-14-17-10-12-29(5)28-17)13-19(26-21(22)16(4)27-30)18-9-8-11-24-23(18)31-7-2/h8-13,15H,6-7,14H2,1-5H3,(H,25,26) GUZUXYPWYDLGJF-UHFFFAOYSA-N 279037 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]-N-[(1-methylpyrazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 67::US10512632, Example 67::US10618913, Example S67::US10766893, Example S67::US10806718, Example 67::US11634416, Example 67 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 9.60 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279037 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279037&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273371 378160626 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530691 CCCOc1ncccc1-c1cc(NCc2nnn(C)n2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C22H29N9O/c1-6-11-32-22-16(9-8-10-23-22)17-12-18(24-13-19-26-29-30(5)28-19)21-20(25-17)15(4)27-31(21)14(3)7-2/h8-10,12,14H,6-7,11,13H2,1-5H3,(H,24,25) DGDYHVXCROBNNK-UHFFFAOYSA-N 279038 3-methyl-1-[1-methylpropyl]-N-[(2-methyltetrazol-5-yl)methyl]-5-(2-propoxy-3-pyridyl)pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 68::US10512632, Example 68::US10766893, Example S68::US10806718, Example 68::US11634416, Example 68 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.790 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279038 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279038&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273364 378160627 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530694 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(ncc2n1)C(C)CC InChI=1S/C22H27N7O/c1-5-15(3)29-21-19(24-11-16-12-25-28(4)14-16)10-18(27-20(21)13-26-29)17-8-7-9-23-22(17)30-6-2/h7-10,12-15H,5-6,11H2,1-4H3,(H,24,27) PNGBBNJWUZFNIY-UHFFFAOYSA-N 279039 5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine, enantiomer 1::US10034861, Example 69::US10034861, Example 70::US10512632, Example 70::US10618913, Example S69::US10766893, Example S70::US10806718, Example 70::US11634416, Example 70 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 14.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279039&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273366 378160628 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530697 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(ncc2n1)C(C)CC InChI=1S/C22H27N7O/c1-5-15(3)29-21-19(24-11-16-12-25-28(4)14-16)10-18(27-20(21)13-26-29)17-8-7-9-23-22(17)30-6-2/h7-10,12-15H,5-6,11H2,1-4H3,(H,24,27) PNGBBNJWUZFNIY-UHFFFAOYSA-N 279039 5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine, enantiomer 1::US10034861, Example 69::US10034861, Example 70::US10512632, Example 70::US10618913, Example S69::US10766893, Example S70::US10806718, Example 70::US11634416, Example 70 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 140 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279039&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273366 378160628 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530700 CCOc1ncccc1-c1cc(NCc2scnc2C)c2n(ccc2n1)C(C)C InChI=1S/C22H25N5OS/c1-5-28-22-16(7-6-9-23-22)18-11-19(24-12-20-15(4)25-13-29-20)21-17(26-18)8-10-27(21)14(2)3/h6-11,13-14H,5,12H2,1-4H3,(H,24,26) ZJUCMUDMRFUTOF-UHFFFAOYSA-N 279041 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(4-methylthiazol-5-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 71 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 170 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279041 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279041&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273367 378160629 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530703 CCOc1ncccc1-c1cc(OCc2cnc(C)o2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H25N5O3/c1-6-28-22-17(8-7-9-23-22)18-10-19(29-12-16-11-24-15(5)30-16)21-20(25-18)14(4)26-27(21)13(2)3/h7-11,13H,6,12H2,1-5H3 PFDYAXRVKURLCH-UHFFFAOYSA-N 279042 5-[[5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-yl]oxymethyl]-2-methyl-oxazole::US10034861, Example 72::US10512632, Example 72::US10766893, Example S72::US10806718, Example 72::US11491140, Example 72::US11634416, Example 72 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 14.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279042&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273372 378160630 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530706 CCOc1ncccc1-c1cc(NCc2ccncn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H25N7O/c1-5-30-22-17(7-6-9-24-22)18-11-19(25-12-16-8-10-23-13-26-16)21-20(27-18)15(4)28-29(21)14(2)3/h6-11,13-14H,5,12H2,1-4H3,(H,25,27) UIVWJGFOIVSSOG-UHFFFAOYSA-N 279043 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(pyrimidin-4-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 73::US10512632, Example 73::US10766893, Example S73::US10806718, Example 73::US11491140, Example 73::US11634416, Example 73 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 81.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279043&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273379 378160631 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530709 CCOc1ncccc1-c1cc(NCc2ncccn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H25N7O/c1-5-30-22-16(8-6-9-25-22)17-12-18(26-13-19-23-10-7-11-24-19)21-20(27-17)15(4)28-29(21)14(2)3/h6-12,14H,5,13H2,1-4H3,(H,26,27) DFFZMDINLLNNPV-UHFFFAOYSA-N 279044 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(pyrimidin-2-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 74::US10512632, Example 74::US10766893, Example S74::US10806718, Example 74::US11491140, Example 74::US11634416, Example 74 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.10 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279044&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273368 378160632 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530712 CCOc1ncccc1-c1cc(NCc2nccc(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O/c1-6-31-23-17(8-7-10-25-23)18-12-19(26-13-20-24-11-9-15(4)27-20)22-21(28-18)16(5)29-30(22)14(2)3/h7-12,14H,6,13H2,1-5H3,(H,26,28) ZCARSOPJYGJCRQ-UHFFFAOYSA-N 279045 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(4-methylpyrimidin-2-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 75::US10512632, Example 75::US10806718, Example 75::US11026923, Example 75::US11491140, Example 75::US11634416, Example 75 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 9.90 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279045&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273374 378160633 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530715 CCOc1ncccc1-c1cc(NCc2cnccn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H25N7O/c1-5-30-22-17(7-6-8-25-22)18-11-19(26-13-16-12-23-9-10-24-16)21-20(27-18)15(4)28-29(21)14(2)3/h6-12,14H,5,13H2,1-4H3,(H,26,27) DTEHKURDWHCADV-UHFFFAOYSA-N 279046 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(pyrazin-2-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 76::US10512632, Example 76::US10766893, Example S76::US10806718, Example 76::US11026923, Example 76::US11491140, Example 76::US11634416, Example 76 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 23.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279046&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273373 378160634 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530718 CCOc1ncccc1-c1cc(NCc2cccnc2C(F)(F)F)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H25F3N6O/c1-5-34-23-17(9-7-11-29-23)18-12-19(21-20(31-18)15(4)32-33(21)14(2)3)30-13-16-8-6-10-28-22(16)24(25,26)27/h6-12,14H,5,13H2,1-4H3,(H,30,31) TZBBGNNWRKPAEH-UHFFFAOYSA-N 279047 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[2-(trifluoromethyl)-3-pyridyl]methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 77::US10512632, Example 77::US10766893, Example S77::US10806718, Example 77::US11026923, Example 77::US11491140, Example 77::US11634416, Example 77 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 21.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279047&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273376 378160635 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530721 CCOc1ncccc1-c1cc(NCc2ccn(C)c(=O)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(8-7-10-25-24)19-13-20(26-14-17-9-11-29(5)21(31)12-17)23-22(27-19)16(4)28-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,26,27) IBAWDCALOOJODQ-UHFFFAOYSA-N 279048 4-[[[5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-yl]amino]methyl]-1-methyl-pyridin-2-one::US10034861, Example 78::US10512632, Example 78::US10766893, Example S78::US10806718, Example 78::US11026923, Example 78::US11491140, Example 78::US11634416, Example 78 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 27.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279048&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273377 378160636 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530724 CCNc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H28N8/c1-6-23-22-17(8-7-9-24-22)18-10-19(25-11-16-12-26-29(5)13-16)21-20(27-18)15(4)28-30(21)14(2)3/h7-10,12-14H,6,11H2,1-5H3,(H,23,24)(H,25,27) ZEUKRJZWWLBXIK-UHFFFAOYSA-N 279049 5-(2-(ethylamino)pyridin-3-yl)-1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 79::US10512632, Example 79::US10766893, Example S79::US10806718, Example 79::US11026923, Example 79::US11491140, Example 79::US11634416, Example 79 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 230 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279049&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273375 378160637 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530727 CCOc1ncccc1-c1cc(NCc2cc(OC)ccn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-19(8-7-10-26-24)20-13-21(27-14-17-12-18(31-5)9-11-25-17)23-22(28-20)16(4)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) BVKDBZHCRMPMSA-UHFFFAOYSA-N 279050 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(4-methoxy-2-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 81::US10512632, Example 81::US10766893, Example S81::US10806718, Example 81::US11026923, Example 81::US11491140, Example 81::US11634416, Example 81 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.000 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279050&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273378 378160638 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530730 CCOc1ncccc1-c1cc(NCc2cncc(OC)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O2/c1-6-32-23-17(8-7-9-25-23)18-10-19(26-12-16-11-24-13-20(27-16)31-5)22-21(28-18)15(4)29-30(22)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,26,28) OSHMEGNKNUJDSU-UHFFFAOYSA-N 279051 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(6-methoxypyrazin-2-yl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 82::US10512632, Example 82::US10766893, Example S82::US10806718, Example 82::US11026923, Example 82::US11491140, Example 82::US11634416, Example 82 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 16.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279051&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273380 378160639 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530733 CCOc1ncccc1-c1cc(NCc2ncc(F)cn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H24FN7O/c1-5-31-22-16(7-6-8-24-22)17-9-18(25-12-19-26-10-15(23)11-27-19)21-20(28-17)14(4)29-30(21)13(2)3/h6-11,13H,5,12H2,1-4H3,(H,25,28) ZIOQYWFVMVDZRK-UHFFFAOYSA-N 279052 5-(2-ethoxy-3-pyridyl)-N-[(5-fluoropyrimidin-2-yl)methyl]-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 83::US10512632, Example 83::US10766893, Example S83::US10806718, Example 83::US11026923, Example 83::US11491140, Example 83::US11634416, Example 83 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 17.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279052&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273381 378160640 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530736 CCOc1ncccc1-c1cc(NCc2cccnc2C)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O/c1-6-31-24-19(10-8-12-26-24)20-13-21(27-14-18-9-7-11-25-16(18)4)23-22(28-20)17(5)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) JOFWPJKNNJOGJF-UHFFFAOYSA-N 279053 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methyl-3-pyridyl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 84::US10512632, Example 84::US10766893, Example S84::US10806718, Example 84::US11026923, Example 84::US11491140, Example 84::US11634416, Example 84 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 19.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279053&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273382 378160641 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530739 CCOc1ncccc1-c1cc(NCc2cccnc2F)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H25FN6O/c1-5-31-23-17(9-7-11-26-23)18-12-19(27-13-16-8-6-10-25-22(16)24)21-20(28-18)15(4)29-30(21)14(2)3/h6-12,14H,5,13H2,1-4H3,(H,27,28) JJLMBZVLDAMDGO-UHFFFAOYSA-N 279054 5-(2-ethoxy-3-pyridyl)-N-[(2-fluoro-3-pyridyl)methyl]-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 85::US10512632, Example 85::US10766893, Example S85::US10806718, Example 85::US11026923, Example 85::US11491140, Example 85::US11634416, Example 85 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.40 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279054&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273384 378160642 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530742 CCOc1ncccc1-c1cc(NCc2cccnc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(10-8-12-26-24)19-13-20(27-14-17-9-7-11-25-23(17)31-5)22-21(28-19)16(4)29-30(22)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) LOZUTDKVJLMDTB-UHFFFAOYSA-N 279055 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 172::US10034861, Example 180::US10034861, Example 181::US10034861, Example 182::US10034861, Example 86::US10512632, Example 86::US10766893, Example S86::US10806718, Example 182::US11026923, Example 182::US11491140, Example 86::US11634416, Example 86 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 20.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279055&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273386 378160643 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530745 CCOc1ncccc1-c1cc(NCc2ccc(C)nc2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O/c1-6-31-24-19(8-7-11-25-24)20-12-21(27-14-18-10-9-16(4)26-13-18)23-22(28-20)17(5)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) VEZPCNBBBMUATR-UHFFFAOYSA-N 279056 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(6-methyl-3-pyridyl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 87::US10512632, Example 87::US10766893, Example S87::US10806718, Example 87::US11026923, Example 87::US11491140, Example 87::US11634416, Example 87 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 6.30 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279056 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279056&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273383 378160644 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530748 CCOc1ncccc1-c1cc(NCc2ccccc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C25H29N5O2/c1-6-32-25-19(11-9-13-26-25)20-14-21(27-15-18-10-7-8-12-22(18)31-5)24-23(28-20)17(4)29-30(24)16(2)3/h7-14,16H,6,15H2,1-5H3,(H,27,28) IXQRCVAKBIMUJN-UHFFFAOYSA-N 279057 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxyphenyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 88::US10512632, Example 88::US10766893, Example S88::US10806718, Example 88::US11026923, Example 88::US11491140, Example 88::US11634416, Example 88 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 110 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279057&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273385 378160645 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530751 CCOc1ncccc1-c1cc(NCc2ccccc2F)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H26FN5O/c1-5-31-24-18(10-8-12-26-24)20-13-21(27-14-17-9-6-7-11-19(17)25)23-22(28-20)16(4)29-30(23)15(2)3/h6-13,15H,5,14H2,1-4H3,(H,27,28) PBVAXRZBSWSQNU-UHFFFAOYSA-N 279058 5-(2-ethoxy-3-pyridyl)-N-[(2-fluorophenyl)methyl]-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 89::US10512632, Example 89::US10766893, Example S89::US10806718, Example 89::US11026923, Example 89::US11491140, Example 89::US11634416, Example 89 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 61.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279058&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273388 378160646 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530754 CCOc1ncccc1-c1cc(NCc2ccccc2C(F)(F)F)c2n(nc(C)c2n1)C(C)C InChI=1S/C25H26F3N5O/c1-5-34-24-18(10-8-12-29-24)20-13-21(23-22(31-20)16(4)32-33(23)15(2)3)30-14-17-9-6-7-11-19(17)25(26,27)28/h6-13,15H,5,14H2,1-4H3,(H,30,31) XUHWSBHEGYQEDI-UHFFFAOYSA-N 279059 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[2-(trifluoromethyl)phenyl]methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 90::US10512632, Example 90::US10766893, Example S90::US10806718, Example 90::US11026923, Example 90::US11491140, Example 90::US11634416, Example 90 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 270 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279059&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273387 378160647 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530757 CCOc1ncccc1-c1cc(NCc2nccnc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O2/c1-6-32-22-16(8-7-9-25-22)17-12-18(27-13-19-23(31-5)26-11-10-24-19)21-20(28-17)15(4)29-30(21)14(2)3/h7-12,14H,6,13H2,1-5H3,(H,27,28) GJZNHSHBNVLOAO-UHFFFAOYSA-N 279060 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(3-methoxypyrazin-2-yl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 91::US10512632, Example 91::US10766893, Example S91::US10806718, Example 91::US11026923, Example 91::US11491140, Example 91::US11634416, Example 91 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 27.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279060&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273389 378160648 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530760 CCOc1ncccc1-c1cc(NCc2cnccc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(8-7-10-26-24)19-12-20(27-14-17-13-25-11-9-21(17)31-5)23-22(28-19)16(4)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) BHINMZMKXRIBEG-UHFFFAOYSA-N 279061 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(4-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 92::US10512632, Example 92::US10766893, Example S92::US10806718, Example 92::US11026923, Example 92::US11491140, Example 92::US11634416, Example 92 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 47.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279061&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273390 378160649 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530763 CCCOc1ncccc1-c1cc(NCc2nnn(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H27N9O/c1-6-10-31-21-15(8-7-9-22-21)16-11-17(23-12-18-25-28-29(5)27-18)20-19(24-16)14(4)26-30(20)13(2)3/h7-9,11,13H,6,10,12H2,1-5H3,(H,23,24) IEZRRRCALKIRBN-UHFFFAOYSA-N 279062 1-isopropyl-3-methyl-N-[(2-methyltetrazol-5-yl)methyl]-5-(2-propoxy-3-pyridyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 93::US10512632, Example 93::US10766893, Example S93::US10806718, Example 93::US11026923, Example 93::US11491140, Example 93::US11634416, Example 93 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4.30 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279062&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273393 378160650 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530766 CCCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H29N7O/c1-6-10-31-23-18(8-7-9-24-23)19-11-20(25-12-17-13-26-29(5)14-17)22-21(27-19)16(4)28-30(22)15(2)3/h7-9,11,13-15H,6,10,12H2,1-5H3,(H,25,27) JYRPZCKZXZYAOY-UHFFFAOYSA-N 279063 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-(2-propoxy-3-pyridyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 94::US10512632, Example 94::US10766893, Example S94::US10806718, Example 94::US11026923, Example 94::US11491140, Example 94::US11634416, Example 94 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.40 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279063&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273391 378160651 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530769 COc1ncccc1CNc1cc(nc2c(C)nn(C(C)C)c12)-c1cccnc1OC InChI=1S/C23H26N6O2/c1-14(2)29-21-19(26-13-16-8-6-10-24-22(16)30-4)12-18(27-20(21)15(3)28-29)17-9-7-11-25-23(17)31-5/h6-12,14H,13H2,1-5H3,(H,26,27) YPNDBZHHIYJRNN-UHFFFAOYSA-N 279064 1-isopropyl-5-(2-methoxy-3-pyridyl)-N-[(2-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 95::US10512632, Example 95::US10766893, Example S95::US10806718, Example 95::US11026923, Example 95::US11491140, Example 95::US11634416, Example 95 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 42.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279064 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279064&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273392 378160652 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530772 COc1ccc(CNc2cc(nc3c(C)nn(C(C)C)c23)-c2cccnc2OC)cn1 InChI=1S/C23H26N6O2/c1-14(2)29-22-19(25-12-16-8-9-20(30-4)26-13-16)11-18(27-21(22)15(3)28-29)17-7-6-10-24-23(17)31-5/h6-11,13-14H,12H2,1-5H3,(H,25,27) HUQJJAUBVULGLS-UHFFFAOYSA-N 279065 1-isopropyl-5-(2-methoxy-3-pyridyl)-N-[(6-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 96::US10512632, Example 96::US10766893, Example S96::US10806718, Example 96::US11026923, Example 96::US11491140, Example 96::US11634416, Example 96 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 18.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279065&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273394 378160653 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530775 CC(C)Oc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H29N7O/c1-14(2)30-22-20(25-11-17-12-26-29(6)13-17)10-19(27-21(22)16(5)28-30)18-8-7-9-24-23(18)31-15(3)4/h7-10,12-15H,11H2,1-6H3,(H,25,27) IWDHUHWZRSHWGD-UHFFFAOYSA-N 279066 5-(2-isopropoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 97::US10512632, Example 97::US10766893, Example S97::US10806718, Example 97::US11026923, Example 97::US11491140, Example 97::US11634416, Example 97 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.40 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279066&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273395 378160654 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530778 CCOc1ncccc1-c1cc(NCc2nc[nH]n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C20H24N8O/c1-5-29-20-14(7-6-8-21-20)15-9-16(22-10-17-23-11-24-26-17)19-18(25-15)13(4)27-28(19)12(2)3/h6-9,11-12H,5,10H2,1-4H3,(H,22,25)(H,23,24,26) ZUZXEJWHRNAFBA-UHFFFAOYSA-N 279067 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1H-1,2,4-triazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 98::US10512632, Example 98::US10766893, Example S98::US10806718, Example 98::US11491140, Example 98::US11634416, Example 98 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 7.20 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279067 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279067&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273396 378160655 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530781 CCOc1ncccc1-c1cc(NCc2nn[nH]n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C19H23N9O/c1-5-29-19-13(7-6-8-20-19)14-9-15(21-10-16-23-26-27-24-16)18-17(22-14)12(4)25-28(18)11(2)3/h6-9,11H,5,10H2,1-4H3,(H,21,22)(H,23,24,26,27) DBRGOFPEANLZGU-UHFFFAOYSA-N 279068 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(2H-tetrazol-5-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 99::US10512632, Example 99::US10766893, Example S99::US10806718, Example 99::US11026923, Example 99::US11491140, Example 99::US11634416, Example 99 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.730 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279068&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273399 378160656 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530784 CCOc1ncccc1-c1cc(NCc2ccccn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H26N6O/c1-5-30-23-18(10-8-12-25-23)19-13-20(26-14-17-9-6-7-11-24-17)22-21(27-19)16(4)28-29(22)15(2)3/h6-13,15H,5,14H2,1-4H3,(H,26,27) GWMDZOSIIBARTA-UHFFFAOYSA-N 279069 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(2-pyridylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 100::US10512632, Example 100::US10766893, Example S100::US10806718, Example 100::US11026923, Example 100::US11491140, Example 100::US11634416, Example 100 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 6.30 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279069&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273397 378160657 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530787 CCOc1ncccc1-c1cc(NCc2cccc(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O/c1-6-31-24-19(11-8-12-25-24)20-13-21(26-14-18-10-7-9-16(4)27-18)23-22(28-20)17(5)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,26,28) HBRGVUVPCCNRAT-UHFFFAOYSA-N 279070 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(6-methyl-2-pyridyl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 101::US10512632, Example 101::US10766893, Example S101::US10806718, Example 101::US11026923, Example 101::US11491140, Example 101::US11634416, Example 101 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 20.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279070&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273398 378160658 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530790 CCOc1ncccc1-c1cc(NCc2cccc(OC)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(10-8-12-25-24)19-13-20(26-14-17-9-7-11-21(27-17)31-5)23-22(28-19)16(4)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,26,28) DHUHVCYRBUZRAT-UHFFFAOYSA-N 279071 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(6-methoxy-2-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 102::US10512632, Example 102::US10766893, Example S102::US10806718, Example 102::US11026923, Example 102::US11491140, Example 102::US11634416, Example 102 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.00 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279071&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273400 378160659 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530793 CCOc1ncccc1-c1cc(NCc2ccnc(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O/c1-6-31-24-19(8-7-10-26-24)20-13-21(27-14-18-9-11-25-16(4)12-18)23-22(28-20)17(5)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) MPJXQIBFZBPJFH-UHFFFAOYSA-N 279072 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methyl-4-pyridyl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 103::US10512632, Example 103::US10766893, Example S103::US10806718, Example 103::US11026923, Example 103::US11491140, Example 103::US11634416, Example 103 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 5.40 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279072&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273402 378160660 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530796 CCOc1ncccc1-c1cc(NCc2ccnc(OC)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(8-7-10-26-24)19-13-20(27-14-17-9-11-25-21(12-17)31-5)23-22(28-19)16(4)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) SJJQCULDRYOYED-UHFFFAOYSA-N 279073 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-4-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 104::US10512632, Example 104::US10766893, Example S104::US10806718, Example 104::US11026923, Example 104::US11491140, Example 104::US11634416, Example 104 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.20 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279073&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273401 378160661 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530799 CCOc1ncccc1-c1cc(NCc2ccnc(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O/c1-6-31-23-18(8-7-10-25-23)19-12-20(26-13-17-9-11-24-16(5)27-17)22-21(28-19)15(4)29-30(22)14(2)3/h7-12,14H,6,13H2,1-5H3,(H,26,28) OEGPBHHKEYGZCG-UHFFFAOYSA-N 279074 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methylpyrimidin-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 105::US10512632, Example 105::US10766893, Example S105::US10806718, Example 105::US11026923, Example 105::US11491140, Example 105::US11634416, Example 105 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 54.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279074&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273403 378160662 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530802 CCOc1ncccc1-c1cc(NCc2cncc(OC)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-19(8-7-9-26-24)20-11-21(27-13-17-10-18(31-5)14-25-12-17)23-22(28-20)16(4)29-30(23)15(2)3/h7-12,14-15H,6,13H2,1-5H3,(H,27,28) JCOKQWFPIMEUNS-UHFFFAOYSA-N 279075 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(5-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 106::US10512632, Example 106::US10766893, Example S106::US10806718, Example 106::US11026923, Example 106::US11491140, Example 106::US11634416, Example 106 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.10 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279075&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273404 378160663 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530805 CCOc1ncccc1-c1cc(NCc2cccc(n2)C(F)(F)F)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H25F3N6O/c1-5-34-23-17(9-7-11-28-23)18-12-19(22-21(31-18)15(4)32-33(22)14(2)3)29-13-16-8-6-10-20(30-16)24(25,26)27/h6-12,14H,5,13H2,1-4H3,(H,29,31) FVVVRFIRYVUVEI-UHFFFAOYSA-N 279076 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[6-(trifluoromethyl)-2-pyridyl]methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 107::US10512632, Example 107::US10766893, Example S107::US10806718, Example 107::US11026923, Example 107::US11491140, Example 107::US11634416, Example 107 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 110 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279076&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273405 378160664 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530808 CCOc1ncccc1-c1cc(NCc2cccn(C)c2=O)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-23-18(10-7-11-25-23)19-13-20(26-14-17-9-8-12-29(5)24(17)31)22-21(27-19)16(4)28-30(22)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,26,27) YLQLMBPUXKUVLD-UHFFFAOYSA-N 279077 3-[[[5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-yl]amino]methyl]-1-methyl-pyridin-2-one::US10034861, Example 108::US10512632, Example 108::US10766893, Example S108::US10806718, Example 108::US11026923, Example 108::US11491140, Example 108::US11634416, Example 108 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.80 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279077&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273406 378160665 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530811 CCOc1ncccc1-c1cc(NCc2cnn(CC)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H29N7O/c1-6-29-14-17(13-26-29)12-25-20-11-19(18-9-8-10-24-23(18)31-7-2)27-21-16(5)28-30(15(3)4)22(20)21/h8-11,13-15H,6-7,12H2,1-5H3,(H,25,27) IEORIQPBXNSJCP-UHFFFAOYSA-N 279078 5-(2-ethoxy-3-pyridyl)-N-[(1-ethylpyrazol-4-yl)methyl]-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 109::US10512632, Example 109::US10766893, Example S109::US10806718, Example 109::US11026923, Example 109::US11491140, Example 109::US11634416, Example 109 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4.90 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279078&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273407 378160666 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530814 CCCn1cc(CNc2cc(nc3c(C)nn(C(C)C)c23)-c2cccnc2OCC)cn1 InChI=1S/C24H31N7O/c1-6-11-30-15-18(14-27-30)13-26-21-12-20(19-9-8-10-25-24(19)32-7-2)28-22-17(5)29-31(16(3)4)23(21)22/h8-10,12,14-16H,6-7,11,13H2,1-5H3,(H,26,28) NPLKFZSTTQLUHS-UHFFFAOYSA-N 279079 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(1-propylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 110::US10512632, Example 110::US10766893, Example S110::US10806718, Example 110::US11026923, Example 110::US11491140, Example 110::US11634416, Example 110 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 11.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279079&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273408 378160667 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530817 CCOc1ncccc1-c1cc(NCc2ccc(OC)nc2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(8-7-11-25-24)19-12-20(26-13-17-9-10-21(31-5)27-14-17)23-22(28-19)16(4)29-30(23)15(2)3/h7-12,14-15H,6,13H2,1-5H3,(H,26,28) XMJAAWKICASNAA-UHFFFAOYSA-N 279080 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(6-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 111::US10512632, Example 111::US10766893, Example S111::US10806718, Example 111::US11026923, Example 111::US11491140, Example 111::US11634416, Example 111 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 28.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279080 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279080&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273409 378160668 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530820 CCOc1ncccc1-c1cc(NCc2ccc(OC)cn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-19(8-7-11-25-24)20-12-21(27-13-17-9-10-18(31-5)14-26-17)23-22(28-20)16(4)29-30(23)15(2)3/h7-12,14-15H,6,13H2,1-5H3,(H,27,28) HWSJSACIWPNYOB-UHFFFAOYSA-N 279081 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(5-methoxy-2-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 112::US10512632, Example 112::US10766893, Example S112::US10806718, Example 112::US11026923, Example 112::US11491140, Example 112::US11634416, Example 112 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 61.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279081&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273411 378160669 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530823 CCOc1ncccc1-c1cc(NCc2csc(C)n2)c2n(nc(C)c2n1)C1COC1 InChI=1S/C22H24N6O2S/c1-4-30-22-17(6-5-7-23-22)18-8-19(24-9-15-12-31-14(3)25-15)21-20(26-18)13(2)27-28(21)16-10-29-11-16/h5-8,12,16H,4,9-11H2,1-3H3,(H,24,26) BSSGJYYHYVLYMA-UHFFFAOYSA-N 279082 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(2-methylthiazol-4-yl)methyl]-1-(oxetan-3-yl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 113::US10512632, Example 113::US10618913, Example S113::US10766893, Example S113::US10806718, Example 113::US11026923, Example 113::US11491140, Example 113::US11634416, Example 113 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 110 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279082&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273410 378160670 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530826 CCOc1ncccc1-c1cc(NCc2cnc(OC)cn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O2/c1-6-32-23-17(8-7-9-24-23)18-10-19(26-11-16-12-27-20(31-5)13-25-16)22-21(28-18)15(4)29-30(22)14(2)3/h7-10,12-14H,6,11H2,1-5H3,(H,26,28) QIWVSVNHRDQBOW-UHFFFAOYSA-N 279083 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(5-methoxypyrazin-2-yl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 114::US10512632, Example 114::US10766893, Example S114::US10806718, Example 114::US11026923, Example 114::US11491140, Example 114::US11634416, Example 114 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 24.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279083 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279083&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273413 378160671 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530829 CCOc1ncccc1-c1cc(NCc2cccnc2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H26N6O/c1-5-30-23-18(9-7-11-25-23)19-12-20(26-14-17-8-6-10-24-13-17)22-21(27-19)16(4)28-29(22)15(2)3/h6-13,15H,5,14H2,1-4H3,(H,26,27) MYYHBCJMEYIHMC-UHFFFAOYSA-N 279084 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(3-pyridylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 115::US10512632, Example 115::US10766893, Example S115::US10806718, Example 115::US11026923, Example 115::US11491140, Example 115::US11634416, Example 115 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 15.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279084&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273412 378160672 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530832 CCOc1ncccc1-c1cc(NCc2ccc(F)nc2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H25FN6O/c1-5-31-23-17(7-6-10-25-23)18-11-19(26-12-16-8-9-20(24)27-13-16)22-21(28-18)15(4)29-30(22)14(2)3/h6-11,13-14H,5,12H2,1-4H3,(H,26,28) SKXWAYULKGVUDE-UHFFFAOYSA-N 279085 5-(2-ethoxy-3-pyridyl)-N-[(6-fluoro-3-pyridyl)methyl]-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 116::US10512632, Example 116::US10766893, Example S116::US10806718, Example 116::US11026923, Example 116::US11491140, Example 116::US11634416, Example 116 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 21.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279085&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273414 378160673 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530835 CCOc1ncccc1-c1cc(NCc2ccc(nc2)C(F)F)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H26F2N6O/c1-5-33-24-17(7-6-10-27-24)19-11-20(22-21(30-19)15(4)31-32(22)14(2)3)29-13-16-8-9-18(23(25)26)28-12-16/h6-12,14,23H,5,13H2,1-4H3,(H,29,30) FDEJYPFAUDLEJD-UHFFFAOYSA-N 279086 N-[[6-(difluoromethyl)-3-pyridyl]methyl]-5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 117::US10512632, Example 117::US10766893, Example S117::US10806718, Example 117::US11026923, Example 117::US11491140, Example 117::US11634416, Example 117 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 18.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279086&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273416 378160674 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530838 CCOc1ncccc1-c1cc(NCc2ncccc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-17(9-7-12-26-24)18-13-19(27-14-20-21(31-5)10-8-11-25-20)23-22(28-18)16(4)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) CQZGCHPJVLXYPV-UHFFFAOYSA-N 279087 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(3-methoxy-2-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 118::US10512632, Example 118::US10766893, Example S118::US10806718, Example 118::US11026923, Example 118::US11491140, Example 118::US11634416, Example 118 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 13.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279087&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273417 378160675 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530841 CCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(nc(C)c2n1)C(C)CC 279088 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 119::US10034861, Example 120::US10512632, Example 120::US10618913, Example S120::US10766893, Example S120::US10806718, Example 120::US11026923, Example 120::US11634416, Example 120 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 12.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279088&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273415 378160676 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530844 CCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(nc(C)c2n1)C(C)CC 279088 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 119::US10034861, Example 120::US10512632, Example 120::US10618913, Example S120::US10766893, Example S120::US10806718, Example 120::US11026923, Example 120::US11634416, Example 120 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4.60 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279088&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273415 378160676 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530847 CCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C22H28N8O/c1-6-14(3)30-21-18(24-12-19-25-13-29(5)28-19)11-17(26-20(21)15(4)27-30)16-9-8-10-23-22(16)31-7-2/h8-11,13-14H,6-7,12H2,1-5H3,(H,24,26) RANZHWURGHEKDD-UHFFFAOYSA-N 279090 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 121::US10034861, Example 122::US10512632, Example 122::US10766893, Example S122::US10806718, Example 122::US11634416, Example 122 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4.00 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279090&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273418 378160677 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530850 CCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C22H28N8O/c1-6-14(3)30-21-18(24-12-19-25-13-29(5)28-19)11-17(26-20(21)15(4)27-30)16-9-8-10-23-22(16)31-7-2/h8-11,13-14H,6-7,12H2,1-5H3,(H,24,26) RANZHWURGHEKDD-UHFFFAOYSA-N 279090 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 121::US10034861, Example 122::US10512632, Example 122::US10766893, Example S122::US10806718, Example 122::US11634416, Example 122 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.20 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279090&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273418 378160677 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530853 CCOc1ncccc1-c1cc(NCc2nnc(C)o2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C22H27N7O2/c1-6-13(3)29-21-18(24-12-19-27-26-15(5)31-19)11-17(25-20(21)14(4)28-29)16-9-8-10-23-22(16)30-7-2/h8-11,13H,6-7,12H2,1-5H3,(H,24,25) SJDHGTJKQKPRAR-UHFFFAOYSA-N 279092 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(5-methyl-1,3,4-oxadiazol-2-yl)methyl]-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 123::US10034861, Example 124::US10512632, Example 123::US10766893, Example S124::US10806718, Example 124::US11634416, Example 124 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 54.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279092&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273419 378160678 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530856 CCOc1ncccc1-c1cc(NCc2nnc(C)o2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C22H27N7O2/c1-6-13(3)29-21-18(24-12-19-27-26-15(5)31-19)11-17(25-20(21)14(4)28-29)16-9-8-10-23-22(16)30-7-2/h8-11,13H,6-7,12H2,1-5H3,(H,24,25) SJDHGTJKQKPRAR-UHFFFAOYSA-N 279092 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(5-methyl-1,3,4-oxadiazol-2-yl)methyl]-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 123::US10034861, Example 124::US10512632, Example 123::US10766893, Example S124::US10806718, Example 124::US11634416, Example 124 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 9.70 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279092&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273419 378160678 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530859 CCOc1ncccc1-c1cc(NCc2cncc(OC)c2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C25H30N6O2/c1-6-16(3)31-24-22(28-14-18-11-19(32-5)15-26-13-18)12-21(29-23(24)17(4)30-31)20-9-8-10-27-25(20)33-7-2/h8-13,15-16H,6-7,14H2,1-5H3,(H,28,29) SYWOKLNWWYOPHL-UHFFFAOYSA-N 279094 5-(2-ethoxy-3-pyridyl)-N-[(5-methoxy-3-pyridyl)methyl]-3-methyl-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 125::US10512632, Example 125::US10766893, Example S125::US10806718, Example 125::US11634416, Example 125 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.000 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279094&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273422 378160679 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530862 CCOc1ncccc1-c1cc(NCc2ccnc(OC)c2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C25H30N6O2/c1-6-16(3)31-24-21(28-15-18-10-12-26-22(13-18)32-5)14-20(29-23(24)17(4)30-31)19-9-8-11-27-25(19)33-7-2/h8-14,16H,6-7,15H2,1-5H3,(H,28,29) JRNBIFGQRNWOKC-UHFFFAOYSA-N 279095 5-(2-ethoxy-3-pyridyl)-N-[(2-methoxy-4-pyridyl)methyl]-3-methyl-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 126::US10512632, Example 126::US10766893, Example S126::US10806718, Example 126::US11634416, Example 126 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 5.40 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279095&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273420 378160680 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530865 CCOc1ncccc1-c1cc(NCc2nnn(C)n2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C21H27N9O/c1-6-13(3)30-20-17(23-12-18-25-28-29(5)27-18)11-16(24-19(20)14(4)26-30)15-9-8-10-22-21(15)31-7-2/h8-11,13H,6-7,12H2,1-5H3,(H,23,24) ULBLNKNNIPTFLN-UHFFFAOYSA-N 279096 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]-N-[(2-methyltetrazol-5-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 127::US10512632, Example 127::US10766893, Example S127::US10806718, Example 127::US11634416, Example 127 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.80 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279096&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273421 378160681 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530868 CCOc1ncccc1-c1cc(NCc2noc(C)n2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C22H27N7O2/c1-6-13(3)29-21-18(24-12-19-25-15(5)31-28-19)11-17(26-20(21)14(4)27-29)16-9-8-10-23-22(16)30-7-2/h8-11,13H,6-7,12H2,1-5H3,(H,24,26) XOIXJVILDWTHEL-UHFFFAOYSA-N 279097 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 128::US10512632, Example 128::US10766893, Example S128::US10806718, Example 128::US11634416, Example 128 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.20 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279097 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279097&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273425 378160682 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530871 CCOc1ncccc1-c1cc(NCc2coc(C)n2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C23H28N6O2/c1-6-14(3)29-22-20(25-12-17-13-31-16(5)26-17)11-19(27-21(22)15(4)28-29)18-9-8-10-24-23(18)30-7-2/h8-11,13-14H,6-7,12H2,1-5H3,(H,25,27) NAPUFLNYEBBQPU-UHFFFAOYSA-N 279098 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(2-methyloxazol-4-yl)methyl]-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 129::US10512632, Example 129::US10766893, Example S129::US10806718, Example 129::US11634416, Example 129 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 11.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279098 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279098&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273423 378160683 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530874 CCOc1ncccc1-c1cc(NCc2c[nH]cn2)c2n(nc(C)c2n1)C(C)CC 279099 5-(2-ethoxy-3-pyridyl)-N-(1H-imidazol-4-ylmethyl)-3-methyl-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 130::US10512632, Example 130::US10766893, Example S130::US10806718, Example 130::US11634416, Example 130 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 11.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279099&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273424 378160684 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530877 CCOc1ncccc1-c1cc(NCc2cc(C)[nH]n2)c2n(nc(C)c2n1)C(C)CC 279100 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]-N-[(5-methyl-1H-pyrazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 131::US10512632, Example 131::US10766893, Example S131::US10806718, Example 131::US11634416, Example 131 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.350 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279100 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279100&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273426 378160685 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530880 CCOc1ncccc1-c1cc(NCc2cn(C)cn2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C23H29N7O/c1-6-15(3)30-22-20(25-12-17-13-29(5)14-26-17)11-19(27-21(22)16(4)28-30)18-9-8-10-24-23(18)31-7-2/h8-11,13-15H,6-7,12H2,1-5H3,(H,25,27) NIXYLBKMUOTNON-UHFFFAOYSA-N 279101 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(1-methylimidazol-4-yl)methyl]-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 132::US10512632, Example 132::US10766893, Example S132::US10806718, Example 132::US11634416, Example 132 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.140 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279101&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273427 378160686 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530883 CCOc1ncccc1-c1cc(NCc2cnc(C)o2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C23H28N6O2/c1-6-14(3)29-22-20(26-13-17-12-25-16(5)31-17)11-19(27-21(22)15(4)28-29)18-9-8-10-24-23(18)30-7-2/h8-12,14H,6-7,13H2,1-5H3,(H,26,27) ZJGPWXQIKUCOGR-UHFFFAOYSA-N 279102 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(2-methyloxazol-5-yl)methyl]-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 133::US10512632, Example 133::US10766893, Example S133::US10806718, Example 133::US11634416, Example 133 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 11.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279102&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273428 378160687 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530886 CCCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C23H30N8O/c1-6-11-32-23-17(9-8-10-24-23)18-12-19(25-13-20-26-14-30(5)29-20)22-21(27-18)16(4)28-31(22)15(3)7-2/h8-10,12,14-15H,6-7,11,13H2,1-5H3,(H,25,27) SXNFSKBWTTYFLI-UHFFFAOYSA-N 279103 3-methyl-1-[1-methylpropyl]-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]-5-(2-propoxy-3-pyridyl)pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 134::US10512632, Example 134::US10766893, Example S134::US10806718, Example 134::US11491140, Example 134::US11634416, Example 134 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.960 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279103&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273429 378160688 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530889 CCCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(nc(C)c2n1)C(C)CC 279104 3-methyl-1-[1-methylpropyl]-5-(2-propoxy-3-pyridyl)-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 135::US10512632, Example 135::US10766893, Example S135::US10806718, Example 135::US11491140, Example 135::US11634416, Example 135 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.90 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279104&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273430 378160689 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530892 CCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(ncc2n1)C(C)CC 279105 5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine, enantiomer 1::US10034861, Example 136::US10034861, Example 137::US10512632, Example 137::US10766893, Example S137::US10806718, Example 137::US11026923, Example 137::US11491140, Example 137::US11634416, Example 137 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 62.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279105&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273431 378160690 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530895 CCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(ncc2n1)C(C)CC 279105 5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine, enantiomer 1::US10034861, Example 136::US10034861, Example 137::US10512632, Example 137::US10766893, Example S137::US10806718, Example 137::US11026923, Example 137::US11491140, Example 137::US11634416, Example 137 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 180 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279105&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273431 378160690 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530898 CCOc1ncccc1-c1cc(NCc2nnc(C)o2)c2n(ncc2n1)C(C)CC InChI=1S/C21H25N7O2/c1-5-13(3)28-20-17(23-12-19-27-26-14(4)30-19)10-16(25-18(20)11-24-28)15-8-7-9-22-21(15)29-6-2/h7-11,13H,5-6,12H2,1-4H3,(H,23,25) BIQGCKNODPBTSC-UHFFFAOYSA-N 279107 5-(2-ethoxy-3-pyridyl)-N-[(5-methyl-1,3,4-oxadiazol-2-yl)methyl]-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 138::US10034861, Example 139::US10512632, Example 139::US10766893, Example S139::US10806718, Example 139::US11026923, Example 139::US11491140, Example 139::US11634416, Example 139 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 93.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279107&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273432 378160691 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530901 CCOc1ncccc1-c1cc(NCc2nnc(C)o2)c2n(ncc2n1)C(C)CC InChI=1S/C21H25N7O2/c1-5-13(3)28-20-17(23-12-19-27-26-14(4)30-19)10-16(25-18(20)11-24-28)15-8-7-9-22-21(15)29-6-2/h7-11,13H,5-6,12H2,1-4H3,(H,23,25) BIQGCKNODPBTSC-UHFFFAOYSA-N 279107 5-(2-ethoxy-3-pyridyl)-N-[(5-methyl-1,3,4-oxadiazol-2-yl)methyl]-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 138::US10034861, Example 139::US10512632, Example 139::US10766893, Example S139::US10806718, Example 139::US11026923, Example 139::US11491140, Example 139::US11634416, Example 139 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 330 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279107&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273432 378160691 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530904 CCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(ncc2n1)C(C)CC InChI=1S/C21H26N8O/c1-5-14(3)29-20-17(23-12-19-24-13-28(4)27-19)10-16(26-18(20)11-25-29)15-8-7-9-22-21(15)30-6-2/h7-11,13-14H,5-6,12H2,1-4H3,(H,23,26) OKQUCPHNAVGTKM-UHFFFAOYSA-N 279109 5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 140::US10034861, Example 141::US10512632, Example 141::US10766893, Example S141::US10806718, Example 141::US11026923, Example 141::US11491140, Example 141::US11634416, Example 141 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 32.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279109&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273433 378160692 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530907 CCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(ncc2n1)C(C)CC InChI=1S/C21H26N8O/c1-5-14(3)29-20-17(23-12-19-24-13-28(4)27-19)10-16(26-18(20)11-25-29)15-8-7-9-22-21(15)30-6-2/h7-11,13-14H,5-6,12H2,1-4H3,(H,23,26) OKQUCPHNAVGTKM-UHFFFAOYSA-N 279109 5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 140::US10034861, Example 141::US10512632, Example 141::US10766893, Example S141::US10806718, Example 141::US11026923, Example 141::US11491140, Example 141::US11634416, Example 141 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 44.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279109&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273433 378160692 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530910 CCCOc1ncccc1-c1cc(NCc2cn(C)cn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H29N7O/c1-6-10-31-23-18(8-7-9-24-23)19-11-20(25-12-17-13-29(5)14-26-17)22-21(27-19)16(4)28-30(22)15(2)3/h7-9,11,13-15H,6,10,12H2,1-5H3,(H,25,27) KLLVPOPJMWWQFO-UHFFFAOYSA-N 279111 1-isopropyl-3-methyl-N-[(1-methylimidazol-4-yl)methyl]-5-(2-propoxy-3-pyridyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 142::US10512632, Example 142::US10766893, Example S142::US10806718, Example 142::US11491140, Example 142::US11634416, Example 142 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.260 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279111&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273434 378160693 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530913 CCCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H27N7O/c1-5-11-30-22-17(7-6-9-23-22)18-12-19(24-13-16-8-10-25-27-16)21-20(26-18)15(4)28-29(21)14(2)3/h6-10,12,14H,5,11,13H2,1-4H3,(H,24,26)(H,25,27) WVFCCHYAETYKIF-UHFFFAOYSA-N 279112 1-isopropyl-3-methyl-5-(2-propoxy-3-pyridyl)-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 143::US10512632, Example 143::US10766893, Example S143::US10806718, Example 143::US11026923, Example 143::US11491140, Example 143::US11634416, Example 143 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 3.80 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279112&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273435 378160694 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530916 CCOc1ncccc1-c1cc(NCc2nc[nH]n2)c2n(nc(C)c2n1)C(C)CC 279113 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]-N-(1H-1,2,4-triazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 144::US10512632, Example 144::US10766893, Example S144::US10806718, Example 144::US11026923, Example 144::US11491140, Example 144::US11634416, Example 144 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 14.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279113&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273438 378160695 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530919 CCCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H28N8O/c1-6-10-31-22-16(8-7-9-23-22)17-11-18(24-12-19-25-13-29(5)28-19)21-20(26-17)15(4)27-30(21)14(2)3/h7-9,11,13-14H,6,10,12H2,1-5H3,(H,24,26) ROWMNTAKQCZGNZ-UHFFFAOYSA-N 279114 1-isopropyl-3-methyl-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]-5-(2-propoxy-3-pyridyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 145::US10512632, Example 145::US10766893, Example S145::US10806718, Example 145::US11026923, Example 145::US11491140, Example 145::US11634416, Example 145 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.410 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279114&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273436 378160696 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530922 CCCOc1ncccc1-c1cc(NCc2nc[nH]n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-5-9-30-21-15(7-6-8-22-21)16-10-17(23-11-18-24-12-25-27-18)20-19(26-16)14(4)28-29(20)13(2)3/h6-8,10,12-13H,5,9,11H2,1-4H3,(H,23,26)(H,24,25,27) RLGQIPCFRYRCDL-UHFFFAOYSA-N 279115 1-isopropyl-3-methyl-5-(2-propoxy-3-pyridyl)-N-(1H-1,2,4-triazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 146::US10512632, Example 146::US10766893, Example S146::US10806718, Example 146::US11026923, Example 146::US11491140, Example 146::US11634416, Example 146 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 3.90 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279115&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273440 378160697 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530925 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1nccs1 InChI=1S/C18H21N7S/c1-11(2)25-17-14(20-8-13-9-21-24(4)10-13)7-15(18-19-5-6-26-18)22-16(17)12(3)23-25/h5-7,9-11H,8H2,1-4H3,(H,20,22) TVGMRVMYCDHOEG-UHFFFAOYSA-N 279116 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-thiazol-2-yl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 147::US10512632, Example 147::US10618913, Example S147::US10766893, Example S147::US10806718, Example 147::US11026923, Example 147::US11491140, Example 147::US11634416, Example 147 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 12.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279116&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273437 378160698 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530928 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1ncc(C)s1 InChI=1S/C19H23N7S/c1-11(2)26-18-15(20-8-14-9-22-25(5)10-14)6-16(19-21-7-12(3)27-19)23-17(18)13(4)24-26/h6-7,9-11H,8H2,1-5H3,(H,20,23) ACZBEPYVSHJPFB-UHFFFAOYSA-N 279117 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-(5-methylthiazol-2-yl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 148::US10512632, Example 148::US10766893, Example S148::US10806718, Example 148::US11026923, Example 148::US11491140, Example 148::US11634416, Example 148 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 110 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279117&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273439 378160699 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530931 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1nc(C)cs1 InChI=1S/C19H23N7S/c1-11(2)26-18-15(20-7-14-8-21-25(5)9-14)6-16(19-22-12(3)10-27-19)23-17(18)13(4)24-26/h6,8-11H,7H2,1-5H3,(H,20,23) HCLONMUJAHJFIH-UHFFFAOYSA-N 279118 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-(4-methylthiazol-2-yl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 149::US10512632, Example 149::US10766893, Example S149::US10806718, Example 149::US11026923, Example 149::US11491140, Example 149::US11634416, Example 149 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 29.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279118&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273441 378160700 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530934 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)N1CC(C)OC1=O InChI=1S/C19H25N7O2/c1-11(2)26-18-15(20-7-14-8-21-24(5)10-14)6-16(22-17(18)13(4)23-26)25-9-12(3)28-19(25)27/h6,8,10-12H,7,9H2,1-5H3,(H,20,22) YBJPEIIVVVNBPC-UHFFFAOYSA-N 279119 3-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]-5-methyl-oxazolidin-2-one::US10034861, Example 150::US10512632, Example 150::US10766893, Example S150::US10806718, Example 150::US11026923, Example 150::US11491140, Example 150::US11634416, Example 150 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 44.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279119&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273442 378160701 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530937 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)N1CCOC1=O InChI=1S/C18H23N7O2/c1-11(2)25-17-14(19-8-13-9-20-23(4)10-13)7-15(21-16(17)12(3)22-25)24-5-6-27-18(24)26/h7,9-11H,5-6,8H2,1-4H3,(H,19,21) CBOOBJUJEUVRPS-UHFFFAOYSA-N 279120 3-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]oxazolidin-2-one::US10034861, Example 151::US10512632, Example 151::US10766893, Example S151::US10806718, Example 151::US11026923, Example 151::US11491140, Example 151::US11634416, Example 151 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 10.00 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279120&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273443 378160702 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530940 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)N1CCC1=O InChI=1S/C18H23N7O/c1-11(2)25-18-14(19-8-13-9-20-23(4)10-13)7-15(24-6-5-16(24)26)21-17(18)12(3)22-25/h7,9-11H,5-6,8H2,1-4H3,(H,19,21) SLJWZSCTWDVJBR-UHFFFAOYSA-N 279121 1-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]azetidin-2-one::US10034861, Example 152::US10512632, Example 152::US10766893, Example S152::US10806718, Example 152::US11026923, Example 152::US11491140, Example 152::US11634416, Example 152 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 48.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279121&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273444 378160703 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530943 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)N1CCN(C1=O)C(C)(C)C InChI=1S/C22H32N8O/c1-14(2)30-20-17(23-11-16-12-24-27(7)13-16)10-18(25-19(20)15(3)26-30)28-8-9-29(21(28)31)22(4,5)6/h10,12-14H,8-9,11H2,1-7H3,(H,23,25) KIFHGJKUXDTDBI-UHFFFAOYSA-N 279122 1-tert-butyl-3-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]imidazolidin-2-one::US10034861, Example 153::US10512632, Example 153::US10766893, Example S153::US10806718, Example 153::US11026923, Example 153::US11491140, Example 153::US11634416, Example 153 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 130 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279122&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273445 378160704 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530946 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)N1CCCC1=O InChI=1S/C19H25N7O/c1-12(2)26-19-15(20-9-14-10-21-24(4)11-14)8-16(22-18(19)13(3)23-26)25-7-5-6-17(25)27/h8,10-12H,5-7,9H2,1-4H3,(H,20,22) CXGJWWJDXYZFFZ-UHFFFAOYSA-N 279123 1-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]pyrrolidin-2-one::US10034861, Example 154::US10512632, Example 154::US10766893, Example S154::US10806718, Example 154::US11026923, Example 154::US11491140, Example 154::US11634416, Example 154 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 26.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279123&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273446 378160705 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530949 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)N1C(C)COC1=O InChI=1S/C19H25N7O2/c1-11(2)26-18-15(20-7-14-8-21-24(5)9-14)6-16(22-17(18)13(4)23-26)25-12(3)10-28-19(25)27/h6,8-9,11-12H,7,10H2,1-5H3,(H,20,22) DXKZTPARVQEQMA-UHFFFAOYSA-N 279124 3-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]-4-methyl-oxazolidin-2-one::US10034861, Example 155::US10512632, Example 155::US10766893, Example S155::US10806718, Example 155::US11026923, Example 155::US11491140, Example 155::US11634416, Example 155 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.20 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279124&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273447 378160706 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530952 CCC1COC(=O)N1c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C20H27N7O2/c1-6-15-11-29-20(28)26(15)17-7-16(21-8-14-9-22-25(5)10-14)19-18(23-17)13(4)24-27(19)12(2)3/h7,9-10,12,15H,6,8,11H2,1-5H3,(H,21,23) CVOILQIVJFYVAQ-UHFFFAOYSA-N 279125 4-ethyl-3-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]oxazolidin-2-one::US10034861, Example 156::US10512632, Example 156::US10766893, Example S156::US10806718, Example 156::US11026923, Example 156::US11491140, Example 156::US11634416, Example 156 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 31.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279125&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273448 378160707 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530955 CCOc1ncccc1-c1cc(CNc2cncc(OC)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-20(8-7-9-26-24)21-10-17(12-27-18-11-19(31-5)14-25-13-18)23-22(28-21)16(4)29-30(23)15(2)3/h7-11,13-15,27H,6,12H2,1-5H3 BXZMPJVMGAVKJS-UHFFFAOYSA-N 279126 N-[[5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-yl]methyl]-5-methoxy-pyridin-3-amine::US10034861, Example 157::US10512632, Example 157::US10766893, Example S157::US10806718, Example 157::US11026923, Example 157::US11491140, Example 157::US11634416, Example 157 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 34.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279126&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273449 378160708 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530958 CCOc1ncccc1-c1cc(CNc2ncn(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-6-30-20-16(8-7-9-22-20)17-10-15(11-23-21-24-12-28(5)27-21)19-18(25-17)14(4)26-29(19)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,23,27) XUAILHHYTLESDG-UHFFFAOYSA-N 279127 N-[[5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-yl]methyl]-1-methyl-1,2,4-triazol-3-amine::US10034861, Example 158::US10512632, Example 158::US10766893, Example S158::US10806718, Example 158::US11026923, Example 158::US11491140, Example 158::US11634416, Example 158 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 23.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279127&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273450 378160709 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530961 CCOc1ncccc1-c1cc(CCc2cncc(OC)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C25H29N5O2/c1-6-32-25-21(8-7-11-27-25)22-13-19(10-9-18-12-20(31-5)15-26-14-18)24-23(28-22)17(4)29-30(24)16(2)3/h7-8,11-16H,6,9-10H2,1-5H3 KRADQTILGMSJGT-UHFFFAOYSA-N 279128 5-(2-ethoxy-3-pyridyl)-1-isopropyl-7-[2-(5-methoxy-3-pyridyl)ethyl]-3-methyl-pyrazolo[4,3-b]pyridine::US10034861, Example 159::US10512632, Example 159::US10766893, Example S159::US10806718, Example 159::US11026923, Example 159::US11491140, Example 159::US11634416, Example 159 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 270 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279128&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273451 378160710 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530964 CCOc1ncccc1-c1cc(CCc2ncn(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H27N7O/c1-6-30-22-17(8-7-11-23-22)18-12-16(9-10-19-24-13-28(5)27-19)21-20(25-18)15(4)26-29(21)14(2)3/h7-8,11-14H,6,9-10H2,1-5H3 DQKKFAGODSQYOO-UHFFFAOYSA-N 279129 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-7-[2-(1-methyl-1,2,4-triazol-3-yl)ethyl]pyrazolo[4,3-b]pyridine::US10034861, Example 160::US10512632, Example 160::US10766893, Example S160::US10806718, Example 160::US11026923, Example 160::US11491140, Example 160::US11634416, Example 160 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 23.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279129&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273452 378160711 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530967 CCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-6-30-21-15(8-7-9-22-21)16-10-17(23-11-18-24-12-28(5)27-18)20-19(25-16)14(4)26-29(20)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,23,25) CJOUFKUESMXTOX-UHFFFAOYSA-N 279001 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 161::US10034861, Example 31::US10512632, Example 31::US10766893, Example S31::US10806718, Example 31::US11026923, Example 31::US11491140, Example 31::US11634416, Example 31 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 60.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279001 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279001&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273330 378160590 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530970 CCOc1ncccc1-c1cc(NCc2nncn2C)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-6-30-21-15(8-7-9-22-21)16-10-17(23-11-18-26-24-12-28(18)5)20-19(25-16)14(4)27-29(20)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,23,25) XEGYXYUUSUWLRL-UHFFFAOYSA-N 279131 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(4-methyl-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 162::US10512632, Example 162::US10766893, Example S162::US11026923, Example 162::US11634416, Example 162 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 100.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279131&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273453 378160712 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530973 CCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(nc(C)c2n1)C1COC1 InChI=1S/C21H24N8O2/c1-4-31-21-15(6-5-7-22-21)16-8-17(23-9-18-24-12-28(3)27-18)20-19(25-16)13(2)26-29(20)14-10-30-11-14/h5-8,12,14H,4,9-11H2,1-3H3,(H,23,25) KHCSAUOHEOUDEI-UHFFFAOYSA-N 279132 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]-1-(oxetan-3-yl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 163::US10512632, Example 163::US10618913, Example S163::US10766893, Example S163::US10806718, Example 163::US11026923, Example 163::US11491140, Example 163::US11634416, Example 163 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 120 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279132&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273457 378160713 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530976 CCOc1ncccc1-c1cc(SCCC(=O)OCC(C)C)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H32N4O3S/c1-7-30-24-18(9-8-11-25-24)19-13-20(32-12-10-21(29)31-14-15(2)3)23-22(26-19)17(6)27-28(23)16(4)5/h8-9,11,13,15-16H,7,10,12,14H2,1-6H3 HVDCJFCTBUPVCE-UHFFFAOYSA-N 279133 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylsulfanyl]pyrazolo[4,3-b]pyridine::US10034861, Example 164::US10806718, Example 164::US11026923, Example 164::US11491140, Example 164::US11634416, Example 164 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 6.80 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279133&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273278 378160714 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530979 CCOc1ncccc1-c1cc(N(Cc2cnn(c2)C(F)F)Cc2ccc(OC)cc2)c2n(nc(C)c2n1)C(C)C InChI=1S/C30H33F2N7O2/c1-6-41-29-24(8-7-13-33-29)25-14-26(28-27(35-25)20(4)36-39(28)19(2)3)37(16-21-9-11-23(40-5)12-10-21)17-22-15-34-38(18-22)30(31)32/h7-15,18-19,30H,6,16-17H2,1-5H3 UXTFTMXAFOTATJ-UHFFFAOYSA-N 279134 N-[[1-(difluoromethyl)pyrazol-4-yl]methyl]-5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 165::US10512632, Example 165::US10618913, Example S165::US11026923, Example 165::US11491140, Example 165::US11634416, Example 165 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 73.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279134&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273284 378160715 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530982 CCOc1ncccc1-c1cc(NCc2cc(CF)on2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H25FN6O2/c1-5-30-22-17(7-6-8-24-22)18-10-19(25-12-15-9-16(11-23)31-28-15)21-20(26-18)14(4)27-29(21)13(2)3/h6-10,13H,5,11-12H2,1-4H3,(H,25,26) XUHFADCPGYKQAR-UHFFFAOYSA-N 279135 5-(2-ethoxy-3-pyridyl)-N-[[5-(fluoromethyl)isoxazol-3-yl]methyl]-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::BDBM425076::US10034861, Example 166::US10512632, Example 166::US10766893, Example S166::US10806718, Example 166::US11026923, Example 166::US11491140, Example 166::US11634416, Example 166 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.10 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279135&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273459 378160716 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530985 CCOc1ncccc1-c1cc(NCc2cc(CF)no2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H25FN6O2/c1-5-30-22-17(7-6-8-24-22)18-10-19(25-12-16-9-15(11-23)28-31-16)21-20(26-18)14(4)27-29(21)13(2)3/h6-10,13H,5,11-12H2,1-4H3,(H,25,26) VTULNMARMGUDCN-UHFFFAOYSA-N 279136 5-(2-ethoxy-3-pyridyl)-N-[[3-(fluoromethyl)isoxazol-5-yl]methyl]-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 167::US10766893, Example S167::US10806718, Example 167::US11026923, Example 167::US11491140, Example 167::US11634416, Example 167 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 11.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279136&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273460 378160717 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530988 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1ncco1 InChI=1S/C18H21N7O/c1-11(2)25-17-14(20-8-13-9-21-24(4)10-13)7-15(18-19-5-6-26-18)22-16(17)12(3)23-25/h5-7,9-11H,8H2,1-4H3,(H,20,22) IMKYKBMLZRNQRQ-UHFFFAOYSA-N 279137 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-oxazol-2-yl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 168::US10512632, Example 168::US10618913, Example S168::US10766893, Example S168::US10806718, Example 168::US11026923, Example 168::US11491140, Example 168::US11634416, Example 168 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 14.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279137&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273461 378160718 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530991 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1cnnn1C InChI=1S/C18H23N9/c1-11(2)27-18-15(19-7-13-8-21-25(4)10-13)6-14(16-9-20-24-26(16)5)22-17(18)12(3)23-27/h6,8-11H,7H2,1-5H3,(H,19,22) YPYKZBZKFWCVCN-UHFFFAOYSA-N 279138 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-(3-methyltriazol-4-yl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 169::US10512632, Example 169::US10618913, Example S169::US10766893, Example S169::US10806718, Example 169::US11026923, Example 169::US11491140, Example 169::US11634416, Example 169 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 610 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279138&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273462 378160719 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530994 COc1ncccc1-c1cc(NCc2cccnc2C(F)(F)F)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H23F3N6O/c1-13(2)32-20-18(29-12-15-7-5-9-27-21(15)23(24,25)26)11-17(30-19(20)14(3)31-32)16-8-6-10-28-22(16)33-4/h5-11,13H,12H2,1-4H3,(H,29,30) GLFDPBHOMZCMEF-UHFFFAOYSA-N 279139 1-isopropyl-5-(2-methoxy-3-pyridyl)-3-methyl-N-[[2-(trifluoromethyl)-3-pyridyl]methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 170::US10512632, Example 170::US10766893, Example S170::US10806718, Example 170::US11026923, Example 170::US11491140, Example 170::US11634416, Example 170 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 42.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279139&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273463 378160720 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 530997 COc1ncccc1CNc1cc(nc2c(C)nn(C(C)C)c12)-c1ccc[nH]c1=O InChI=1S/C22H24N6O2/c1-13(2)28-20-18(25-12-15-7-5-10-24-22(15)30-4)11-17(26-19(20)14(3)27-28)16-8-6-9-23-21(16)29/h5-11,13H,12H2,1-4H3,(H,23,29)(H,25,26) YJCZMNIYQABZMT-UHFFFAOYSA-N 279140 3-[1-isopropyl-7-[(2-methoxy-3-pyridyl)methylamino]-3-methyl-pyrazolo[4,3-b]pyridin-5-yl]-1H-pyridin-2-one::US10034861, Example 171::US10512632, Example 171::US10766893, Example S171::US10806718, Example 171::US11026923, Example 171::US11491140, Example 171::US11634416, Example 171 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 290 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279140 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279140&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 136214892 378160721 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 531000 CCOc1ncccc1-c1cc(NCc2cccnc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(10-8-12-26-24)19-13-20(27-14-17-9-7-11-25-23(17)31-5)22-21(28-19)16(4)29-30(22)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) LOZUTDKVJLMDTB-UHFFFAOYSA-N 279055 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 172::US10034861, Example 180::US10034861, Example 181::US10034861, Example 182::US10034861, Example 86::US10512632, Example 86::US10766893, Example S86::US10806718, Example 182::US11026923, Example 182::US11491140, Example 86::US11634416, Example 86 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 40.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279055&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273386 378160643 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 531003 COc1ncccc1-c1cc(NCc2cnc(C)s2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H24N6OS/c1-12(2)27-20-18(24-11-15-10-23-14(4)29-15)9-17(25-19(20)13(3)26-27)16-7-6-8-22-21(16)28-5/h6-10,12H,11H2,1-5H3,(H,24,25) SVOMGFJYTSFSPH-UHFFFAOYSA-N 279142 1-isopropyl-5-(2-methoxy-3-pyridyl)-3-methyl-N-[(2-methylthiazol-5-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 173::US10512632, Example 173::US10766893, Example S173::US11026923, Example 173::US11491140, Example 173::US11634416, Example 173 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 49.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279142&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273465 378160722 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 531006 COc1ncccc1CNc1cc(nc2c(C)nn(C(C)C)c12)-c1cccnc1OC1CC1 InChI=1S/C25H28N6O2/c1-15(2)31-23-21(28-14-17-7-5-11-26-24(17)32-4)13-20(29-22(23)16(3)30-31)19-8-6-12-27-25(19)33-18-9-10-18/h5-8,11-13,15,18H,9-10,14H2,1-4H3,(H,28,29) QLFKDVQWAWXRKU-UHFFFAOYSA-N 279143 5-(2-cyclopropoxypyridin-3-yl)-1-isopropyl-N-((2-methoxypyridin-3-yl)methyl)-3-methyl-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 174::US10512632, Example 174::US10766893, Example S174::US10806718, Example 174::US11026923, Example 174::US11491140, Example 174::US11634416, Example 174 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 18.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279143 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279143&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273466 378160723 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 531009 COc1ncccc1CNc1cc(nc2c(C)nn(C(C)C)c12)-c1ccnn1C InChI=1S/C21H25N7O/c1-13(2)28-20-17(23-12-15-7-6-9-22-21(15)29-5)11-16(18-8-10-24-27(18)4)25-19(20)14(3)26-28/h6-11,13H,12H2,1-5H3,(H,23,25) CROUXODBTXNMIZ-UHFFFAOYSA-N 279144 1-isopropyl-N-((2-methoxypyridin-3-yl)methyl)-3-methyl-5-(1-methyl-1H-pyrazol-5-yl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 175::US10512632, Example 175::US10766893, Example S175::US10806718, Example 175::US11026923, Example 175::US11491140, Example 175::US11634416, Example 175 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 83.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279144&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273467 378160724 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 531012 CCOc1ncccc1-c1cc(NCc2ncc(OC)cn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O2/c1-6-32-23-17(8-7-9-24-23)18-10-19(25-13-20-26-11-16(31-5)12-27-20)22-21(28-18)15(4)29-30(22)14(2)3/h7-12,14H,6,13H2,1-5H3,(H,25,28) NLZDQEYNQWGPGP-UHFFFAOYSA-N 279145 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(5-methoxypyrimidin-2-yl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 176::US10512632, Example 176::US10766893, Example S176::US10806718, Example 176::US11026923, Example 176::US11491140, Example 176::US11634416, Example 176 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 81.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279145&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273468 378160725 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 531015 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1ccc[nH]c1=O InChI=1S/C20H23N7O/c1-12(2)27-19-17(22-9-14-10-23-26(4)11-14)8-16(24-18(19)13(3)25-27)15-6-5-7-21-20(15)28/h5-8,10-12H,9H2,1-4H3,(H,21,28)(H,22,24) ZZXWQIDOSVIHIM-UHFFFAOYSA-N 279146 3-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]-1H-pyridin-2-one::US10034861, Example 177::US10512632, Example 177::US10766893, Example S177::US10806718, Example 177::US11026923, Example 177::US11491140, Example 177::US11634416, Example 177 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 130 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279146&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 136214893 378160726 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 531018 CCOc1ncccc1-c1cc(NCc2cccnc2C(F)F)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H26F2N6O/c1-5-33-24-17(9-7-11-28-24)18-12-19(22-20(30-18)15(4)31-32(22)14(2)3)29-13-16-8-6-10-27-21(16)23(25)26/h6-12,14,23H,5,13H2,1-4H3,(H,29,30) IRSHUSVLDQPATB-UHFFFAOYSA-N 279147 N-[[2-(difluoromethyl)-3-pyridyl]methyl]-5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 178::US10512632, Example 178::US10766893, Example S178::US10806718, Example 178::US11026923, Example 178::US11491140, Example 178::US11634416, Example 178 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 31.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279147&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273469 378160727 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 531021 CCOc1ncccc1-c1cc(NCc2cc(OC)ncn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O2/c1-6-32-23-17(8-7-9-24-23)18-11-19(25-12-16-10-20(31-5)27-13-26-16)22-21(28-18)15(4)29-30(22)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,25,28) RTCQCKBUFIYEDZ-UHFFFAOYSA-N 279148 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(6-methoxypyrimidin-4-yl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 179::US10512632, Example 179::US10766893, Example S179::US10806718, Example 179::US11026923, Example 179::US11491140, Example 179::US11634416, Example 179 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.80 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279148&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273471 378160728 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 531024 CCOc1ncccc1-c1cc(NCc2cccnc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(10-8-12-26-24)19-13-20(27-14-17-9-7-11-25-23(17)31-5)22-21(28-19)16(4)29-30(22)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) LOZUTDKVJLMDTB-UHFFFAOYSA-N 279055 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 172::US10034861, Example 180::US10034861, Example 181::US10034861, Example 182::US10034861, Example 86::US10512632, Example 86::US10766893, Example S86::US10806718, Example 182::US11026923, Example 182::US11491140, Example 86::US11634416, Example 86 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 27.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279055&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273386 378160643 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 531027 CCOc1ncccc1-c1cc(NCc2cccnc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(10-8-12-26-24)19-13-20(27-14-17-9-7-11-25-23(17)31-5)22-21(28-19)16(4)29-30(22)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) LOZUTDKVJLMDTB-UHFFFAOYSA-N 279055 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 172::US10034861, Example 180::US10034861, Example 181::US10034861, Example 182::US10034861, Example 86::US10512632, Example 86::US10766893, Example S86::US10806718, Example 182::US11026923, Example 182::US11491140, Example 86::US11634416, Example 86 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 31.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279055&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273386 378160643 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 531030 CCOc1ncccc1-c1cc(NCc2cccnc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(10-8-12-26-24)19-13-20(27-14-17-9-7-11-25-23(17)31-5)22-21(28-19)16(4)29-30(22)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) LOZUTDKVJLMDTB-UHFFFAOYSA-N 279055 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 172::US10034861, Example 180::US10034861, Example 181::US10034861, Example 182::US10034861, Example 86::US10512632, Example 86::US10766893, Example S86::US10806718, Example 182::US11026923, Example 182::US11491140, Example 86::US11634416, Example 86 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 24.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279055&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273386 378160643 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 531033 COc1ncccc1CNc1cc(nc2c(C)nn(C(C)C)c12)-c1cccnc1C(F)(F)F InChI=1S/C23H23F3N6O/c1-13(2)32-20-18(29-12-15-7-5-10-28-22(15)33-4)11-17(30-19(20)14(3)31-32)16-8-6-9-27-21(16)23(24,25)26/h5-11,13H,12H2,1-4H3,(H,29,30) AAAZUNCZBZHDPM-UHFFFAOYSA-N 279152 1-isopropyl-N-((2-methoxypyridin-3-yl)methyl)-3-methyl-5-(2-(trifluoromethyl)pyridin-3-yl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 183::US10512632, Example 183::US10766893, Example S183::US10806718, Example 183::US11634416, Example 183 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 290 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279152&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273472 378160729 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 531036 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C(F)F)c2n1)C(C)C InChI=1S/C22H25F2N7O/c1-5-32-22-15(7-6-8-25-22)16-9-17(26-10-14-11-27-30(4)12-14)20-18(28-16)19(21(23)24)29-31(20)13(2)3/h6-9,11-13,21H,5,10H2,1-4H3,(H,26,28) YFAHCXPQQYYPCW-UHFFFAOYSA-N 279153 3-(difluoromethyl)-5-(2-ethoxypyridin-3-yl)-1-isopropyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 184::US10512632, Example 184::US10618913, Example S184::US10766893, Example S184::US10806718, Example 184::US11491140, Example 184::US11634416, Example 184 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 13.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279153&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273473 378160730 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 531039 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-n1cncn1 InChI=1S/C17H21N9/c1-11(2)26-17-14(19-6-13-7-20-24(4)8-13)5-15(25-10-18-9-21-25)22-16(17)12(3)23-26/h5,7-11H,6H2,1-4H3,(H,19,22) VELNJFTUSCXPKE-UHFFFAOYSA-N 279154 1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-5-(1H-1,2,4-triazol-1-yl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 185::US10512632, Example 185::US10766893, Example S185::US10806718, Example 185::US11026923, Example 185::US11491140, Example 185::US11634416, Example 185 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 100.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279154&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273474 378160731 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 531042 CC(C)n1nc(C)c2nc(cc(NCc3ncn(C)n3)c12)-c1ccc[nH]c1=O InChI=1S/C19H22N8O/c1-11(2)27-18-15(21-9-16-22-10-26(4)25-16)8-14(23-17(18)12(3)24-27)13-6-5-7-20-19(13)28/h5-8,10-11H,9H2,1-4H3,(H,20,28)(H,21,23) LRKYMHYCQWOGDT-UHFFFAOYSA-N 279155 3-[1-isopropyl-3-methyl-7-[(1-methyl-1,2,4-triazol-3-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]-1H-pyridin-2-one::US10034861, Example 186::US10512632, Example 186::US10766893, Example S186::US10806718, Example 186::US11026923, Example 186::US11491140, Example 186::US11634416, Example 186 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 64.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279155&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 136214894 378160732 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 531045 CC(C)n1nc(C)c2nc(cc(NCc3cc[nH]n3)c12)-c1ccc[nH]c1=O InChI=1S/C19H21N7O/c1-11(2)26-18-16(21-10-13-6-8-22-24-13)9-15(23-17(18)12(3)25-26)14-5-4-7-20-19(14)27/h4-9,11H,10H2,1-3H3,(H,20,27)(H,21,23)(H,22,24) FWAXXZSYYYRIBS-UHFFFAOYSA-N 279156 3-[1-isopropyl-3-methyl-7-(1H-pyrazol-3-ylmethylamino)pyrazolo[4,3-b]pyridin-5-yl]-1H-pyridin-2-one::US10034861, Example 187::US10512632, Example 187::US10766893, Example S187::US10806718, Example 187::US11026923, Example 187::US11491140, Example 187::US11634416, Example 187 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 140 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279156&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 136214895 378160733 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 531048 COc1ncccc1CNc1cc(nc2c(C)nn(C(C)C)c12)-c1cccnc1OC(F)F InChI=1S/C23H24F2N6O2/c1-13(2)31-20-18(28-12-15-7-5-9-26-21(15)32-4)11-17(29-19(20)14(3)30-31)16-8-6-10-27-22(16)33-23(24)25/h5-11,13,23H,12H2,1-4H3,(H,28,29) HFYVDFFGOVRRIK-UHFFFAOYSA-N 279157 5-[2-(difluoromethoxy)-3-pyridyl]-1-isopropyl-N-[(2-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 188::US10512632, Example 188::US10766893, Example S188::US11026923, Example 188::US11491140, Example 188::US11634416, Example 188 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 61.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279157&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273478 378160734 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 531051 CCOc1ncccc1-c1cc(NCc2nccc(OC)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O2/c1-6-32-23-16(8-7-10-25-23)17-12-18(26-13-19-24-11-9-20(28-19)31-5)22-21(27-17)15(4)29-30(22)14(2)3/h7-12,14H,6,13H2,1-5H3,(H,26,27) ZRCQWXKCYCHOGM-UHFFFAOYSA-N 279158 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(4-methoxypyrimidin-2-yl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 189::US10512632, Example 189::US10766893, Example S189::US10806718, Example 189::US11026923, Example 189::US11491140, Example 189::US11634416, Example 189 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 3.90 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279158&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273477 378160735 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 531054 CCOc1ncccc1-c1cc(NCc2cncnc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O2/c1-6-32-23-17(8-7-9-25-23)18-10-19(26-12-16-11-24-13-27-22(16)31-5)21-20(28-18)15(4)29-30(21)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,26,28) FQSCOMBJMAVYMG-UHFFFAOYSA-N 279159 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(4-methoxypyrimidin-5-yl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 190::US10512632, Example 190::US10766893, Example S190::US10806718, Example 190::US11026923, Example 190::US11491140, Example 190::US11634416, Example 190 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 74.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279159&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273480 378160736 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 531057 CCOc1ncccc1CNc1cc(nc2c(C)nn(C(C)C)c12)-c1cccnc1OCC InChI=1S/C25H30N6O2/c1-6-32-24-18(10-8-12-26-24)15-28-21-14-20(19-11-9-13-27-25(19)33-7-2)29-22-17(5)30-31(16(3)4)23(21)22/h8-14,16H,6-7,15H2,1-5H3,(H,28,29) RPFGIRQWMRKNBU-UHFFFAOYSA-N 279160 5-(2-ethoxy-3-pyridyl)-N-[(2-ethoxy-3-pyridyl)methyl]-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 191::US10512632, Example 191::US10766893, Example S191::US10806718, Example 191::US11026923, Example 191::US11491140, Example 191::US11634416, Example 191 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 160 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279160&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273479 378160737 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 531060 COc1ccc(CNc2cc(nc3c(C)nn(C(C)C)c23)-c2cccnc2N(C)C)cc1 InChI=1S/C25H30N6O/c1-16(2)31-24-22(27-15-18-9-11-19(32-6)12-10-18)14-21(28-23(24)17(3)29-31)20-8-7-13-26-25(20)30(4)5/h7-14,16H,15H2,1-6H3,(H,27,28) RMYFPLHNAGFJMC-UHFFFAOYSA-N 279161 5-[2-(dimethylamino)-3-pyridyl]-1-isopropyl-N-[(4-methoxyphenyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 192::US10512632, Example 192::US10766893, Example S192::US10806718, Example 192::US11026923, Example 192::US11491140, Example 192::US11634416, Example 192 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 630 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279161&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273481 378160738 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 531063 CC(C)n1nc(C)c2nc(cc(NCc3cccnc3C(F)(F)F)c12)-c1ccc[nH]c1=O InChI=1S/C22H21F3N6O/c1-12(2)31-19-17(28-11-14-6-4-8-26-20(14)22(23,24)25)10-16(29-18(19)13(3)30-31)15-7-5-9-27-21(15)32/h4-10,12H,11H2,1-3H3,(H,27,32)(H,28,29) CEASKHHYUJNGEA-UHFFFAOYSA-N 279162 3-[1-isopropyl-3-methyl-7-[[2-(trifluoromethyl)-3-pyridyl]methylamino]pyrazolo[4,3-b]pyridin-5-yl]-1H-pyridin-2-one::US10034861, Example 193::US10512632, Example 193::US10766893, Example S193::US10806718, Example 193::US11491140, Example 193::US11634416, Example 193 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 320 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279162&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 136214896 378160739 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 531066 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1conc1C InChI=1S/C19H23N7O/c1-11(2)26-19-17(20-7-14-8-21-25(5)9-14)6-16(15-10-27-24-12(15)3)22-18(19)13(4)23-26/h6,8-11H,7H2,1-5H3,(H,20,22) MTWLSLCQXJXQNM-UHFFFAOYSA-N 279163 1-isopropyl-3-methyl-5-(3-methylisoxazol-4-yl)-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 194::US10512632, Example 194::US10766893, Example S194::US10806718, Example 194::US11491140, Example 194::US11634416, Example 194 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 95.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279163&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273485 378160740 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 531069 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1ncnn1C InChI=1S/C18H23N9/c1-11(2)27-17-14(19-7-13-8-21-25(4)9-13)6-15(18-20-10-22-26(18)5)23-16(17)12(3)24-27/h6,8-11H,7H2,1-5H3,(H,19,23) KYLSIDIKSXHHCI-UHFFFAOYSA-N 279164 1-isopropyl-3-methyl-5-(1-methyl-1H-1,2,4-triazol-5-yl)-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 195::US10512632, Example 195::US10618913, Example S195::US10766893, Example S195::US10806718, Example 195::US11026923, Example 195::US11634416, Example 195 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 420 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279164&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273486 378160741 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 531072 CCCOc1ncccc1-c1cc(NCc2cn[nH]c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H27N7O/c1-5-9-30-22-17(7-6-8-23-22)18-10-19(24-11-16-12-25-26-13-16)21-20(27-18)15(4)28-29(21)14(2)3/h6-8,10,12-14H,5,9,11H2,1-4H3,(H,24,27)(H,25,26) FTOYLOIRXWDMMT-UHFFFAOYSA-N 279165 1-isopropyl-3-methyl-5-(2-propoxy-3-pyridyl)-N-(1H-pyrazol-4-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 196::US10512632, Example 196::US11491140, Example 196::US11634416, Example 196 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 18.0 7.6 25.00 C US Patent 10.7270/Q2X350HN aid1795567 US10034861 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279165&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273488 378160742 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 878730 CCSc1c2c(nn1Cc1ccc(cc1)-c1cccc(F)n1)N1CC(C)(C)N=C1N(C)C2=O InChI=1S/C24H25FN6OS/c1-5-33-22-19-20(30-14-24(2,3)27-23(30)29(4)21(19)32)28-31(22)13-15-9-11-16(12-10-15)17-7-6-8-18(25)26-17/h6-12H,5,13-14H2,1-4H3 WSKXIQFITDCMOE-UHFFFAOYSA-N 433319 3-(ethylthio)-2-(4-(6-fluoropyridin-2-yl)benzyl)-5,7,7-trimethyl-7,8-dihydro-2H-imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(5H)-one::US10561656, Example 2 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.000 US Patent 10.7270/Q2ZP48HR aid1804208 US10561656 Li, P; Zheng, H; Zhao, J; Wennogle, LP INTRA-CELLULAR THERAPIES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=433319 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=433319&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 71114269 438642252 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 580106 CN1C2=NC(C)(C)CN2c2nn(Cc3ccc(cc3)C(C)=O)c(Nc3ccc(F)cc3)c2C1=O InChI=1S/C25H25FN6O2/c1-15(33)17-7-5-16(6-8-17)13-32-21(27-19-11-9-18(26)10-12-19)20-22(29-32)31-14-25(2,3)28-24(31)30(4)23(20)34/h5-12,27H,13-14H2,1-4H3 RKEUHNQOPBPRQD-UHFFFAOYSA-N 168126 US9073936, 1::US9598426, 1 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.200 US Patent 10.7270/Q29S1T2J aid1796122 US9598426 Li, P; Zheng, H; Zhao, J; Wennogle, L Intra-Cellular Therapies Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168126&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 90409046 312525529 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 580108 CC(O)c1ccc(Cn2nc3N4CC(C)(C)N=C4N(C)C(=O)c3c2Nc2ccc(F)cc2)cc1 InChI=1S/C25H27FN6O2/c1-15(33)17-7-5-16(6-8-17)13-32-21(27-19-11-9-18(26)10-12-19)20-22(29-32)31-14-25(2,3)28-24(31)30(4)23(20)34/h5-12,15,27,33H,13-14H2,1-4H3 PSUHAEXBWCRQED-UHFFFAOYSA-N 168127 US9073936, 2::US9598426, 2 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.500 US Patent 10.7270/Q29S1T2J aid1796122 US9598426 Li, P; Zheng, H; Zhao, J; Wennogle, L Intra-Cellular Therapies Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168127&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 86279224 312525530 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 580110 CN1C2=NC(C)(C)CN2c2nn(Cc3ccc(cc3)C(C)=O)c(Nc3ccc(F)c(F)c3)c2C1=O InChI=1S/C25H24F2N6O2/c1-14(34)16-7-5-15(6-8-16)12-33-21(28-17-9-10-18(26)19(27)11-17)20-22(30-33)32-13-25(2,3)29-24(32)31(4)23(20)35/h5-11,28H,12-13H2,1-4H3 ITYGOFCAYSOSFS-UHFFFAOYSA-N 168128 US9073936, 3::US9598426, 3 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.300 US Patent 10.7270/Q29S1T2J aid1796122 US9598426 Li, P; Zheng, H; Zhao, J; Wennogle, L Intra-Cellular Therapies Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168128&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 86279223 312525531 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 580112 CN1C2=NC(C)(C)CN2c2nn(Cc3ccc(cc3)C(C)=O)c(Nc3ccc(F)c(C)c3)c2C1=O InChI=1S/C26H27FN6O2/c1-15-12-19(10-11-20(15)27)28-22-21-23(32-14-26(3,4)29-25(32)31(5)24(21)35)30-33(22)13-17-6-8-18(9-7-17)16(2)34/h6-12,28H,13-14H2,1-5H3 KQMWFBJUYHOBDC-UHFFFAOYSA-N 168129 US9073936, 4::US9598426, 4 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.100 US Patent 10.7270/Q29S1T2J aid1796122 US9598426 Li, P; Zheng, H; Zhao, J; Wennogle, L Intra-Cellular Therapies Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168129&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 86279161 312525532 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 50816068 CC[C@@H](NC(=O)c1cnn2cc(C)cnc12)c1ccc(OC(F)(F)F)cc1 InChI=1S/C18H17F3N4O2/c1-3-15(12-4-6-13(7-5-12)27-18(19,20)21)24-17(26)14-9-23-25-10-11(2)8-22-16(14)25/h4-10,15H,3H2,1-2H3,(H,24,26)/t15-/m1/s1 CXEGBNQZVKLHTO-OAHLLOKOSA-N 50258268 CHEMBL4059831::US11419874, Example 21 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >10000 ChEMBL 10.1021/acs.jmedchem.7b00709 10.7270/Q2TT4TD5 28759228 Mikami, S; Sasaki, S; Asano, Y; Ujikawa, O; Fukumoto, S; Nakashima, K; Oki, H; Kamiguchi, N; Imada, H; Iwashita, H; Taniguchi, T Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50258268 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50258268&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 87R 137348687 402361479 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 50819041 COC[C@@H](NC(=O)N1CC(=O)Nc2cc(OC)cnc12)c1ccc(OC(F)(F)F)c(F)c1 InChI=1S/C19H18F4N4O5/c1-30-9-14(10-3-4-15(12(20)5-10)32-19(21,22)23)26-18(29)27-8-16(28)25-13-6-11(31-2)7-24-17(13)27/h3-7,14H,8-9H2,1-2H3,(H,25,28)(H,26,29)/t14-/m1/s1 AWJSRXUQLSPAOI-CQSZACIVSA-N 50258896 CHEMBL4060569::US11419874, TAK-915 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2497 ChEMBL 10.1021/acs.jmedchem.7b00807 10.7270/Q2P271JR 28796496 Mikami, S; Nakamura, S; Ashizawa, T; Nomura, I; Kawasaki, M; Sasaki, S; Oki, H; Kokubo, H; Hoffman, ID; Zou, H; Uchiyama, N; Nakashima, K; Kamiguchi, N; Imada, H; Suzuki, N; Iwashita, H; Taniguchi, T Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50258896 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50258896&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 9GJ 72190879 402361653 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 50819592 CCC(NC(=O)N1CC(=O)Nc2cccnc12)c1ccc(OC(F)(F)F)cc1 InChI=1S/C18H17F3N4O3/c1-2-13(11-5-7-12(8-6-11)28-18(19,20)21)24-17(27)25-10-15(26)23-14-4-3-9-22-16(14)25/h3-9,13H,2,10H2,1H3,(H,23,26)(H,24,27) OZDUBIZEHLUYCU-UHFFFAOYSA-N 50258898 CHEMBL4064344 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 3200 ChEMBL 10.1021/acs.jmedchem.7b00807 10.7270/Q2P271JR 28796496 Mikami, S; Nakamura, S; Ashizawa, T; Nomura, I; Kawasaki, M; Sasaki, S; Oki, H; Kokubo, H; Hoffman, ID; Zou, H; Uchiyama, N; Nakashima, K; Kamiguchi, N; Imada, H; Suzuki, N; Iwashita, H; Taniguchi, T Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50258898 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50258898&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 117949009 402361655 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 50769183 CN(C)C(=O)c1cccc(c1)S(=O)(=O)N1CCC[C@H]1C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 InChI=1S/C32H33Cl2F2N3O8S/c1-37(2)30(40)21-5-3-6-22(13-21)48(43,44)39-12-4-7-26(39)31(41)46-28(15-23-24(33)16-38(42)17-25(23)34)20-10-11-27(47-32(35)36)29(14-20)45-18-19-8-9-19/h3,5-6,10-11,13-14,16-17,19,26,28,32H,4,7-9,12,15,18H2,1-2H3/t26-,28-/m0/s1 MTVYRGXACZGKJC-XCZPVHLTSA-N 50246908 CHEMBL4093768 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 25600 ChEMBL 10.1021/acs.jmedchem.7b01044 10.7270/Q25H7JN4 29200281 Carzaniga, L; Amari, G; Rizzi, A; Capaldi, C; De Fanti, R; Ghidini, E; Villetti, G; Carnini, C; Moretto, N; Facchinetti, F; Caruso, P; Marchini, G; Battipaglia, L; Patacchini, R; Cenacchi, V; Volta, R; Amadei, F; Pappani, A; Capacchi, S; Bagnacani, V; Delcanale, M; Puccini, P; Catinella, S; Civelli, M; Armani, E Chiesi Farmaceutici S.p.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50246908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50246908&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 71092519 401960665 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 50769184 CN(C)C(=O)c1cccc(c1)S(=O)(=O)N1CCS[C@H]1C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 InChI=1S/C31H31Cl2F2N3O8S2/c1-36(2)28(39)20-4-3-5-21(12-20)48(42,43)38-10-11-47-29(38)30(40)45-26(14-22-23(32)15-37(41)16-24(22)33)19-8-9-25(46-31(34)35)27(13-19)44-17-18-6-7-18/h3-5,8-9,12-13,15-16,18,26,29,31H,6-7,10-11,14,17H2,1-2H3/t26-,29-/m0/s1 KOVUQUXRMIAWMX-WNJJXGMVSA-N 50246909 CHEMBL4075951 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 7400 ChEMBL 10.1021/acs.jmedchem.7b01044 10.7270/Q25H7JN4 29200281 Carzaniga, L; Amari, G; Rizzi, A; Capaldi, C; De Fanti, R; Ghidini, E; Villetti, G; Carnini, C; Moretto, N; Facchinetti, F; Caruso, P; Marchini, G; Battipaglia, L; Patacchini, R; Cenacchi, V; Volta, R; Amadei, F; Pappani, A; Capacchi, S; Bagnacani, V; Delcanale, M; Puccini, P; Catinella, S; Civelli, M; Armani, E Chiesi Farmaceutici S.p.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50246909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50246909&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 71092344 401960666 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 50927331 COc1ccc2c(N[C@H](C)Cc3cc(C)[nH]n3)ncnc2c1OC InChI=1S/C17H21N5O2/c1-10(7-12-8-11(2)21-22-12)20-17-13-5-6-14(23-3)16(24-4)15(13)18-9-19-17/h5-6,8-10H,7H2,1-4H3,(H,21,22)(H,18,19,20)/t10-/m1/s1 JTROLECZHRVLFM-SNVBAGLBSA-N 50272570 CHEMBL4129844 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 777 ChEMBL 10.1021/acs.jmedchem.8b00374 10.7270/Q2J67KDQ 29718668 Humphrey, JM; Movsesian, M; Am Ende, CW; Becker, SL; Chappie, TA; Jenkinson, S; Liras, JL; Liras, S; Orozco, C; Pandit, J; Vajdos, FF; Vandeput, F; Yang, E; Menniti, FS Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50272570 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50272570&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 145961173 405256310 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 50927333 COc1ccc2c(N[C@@H](C)Cc3cc(C)[nH]n3)ncnc2c1OC InChI=1S/C17H21N5O2/c1-10(7-12-8-11(2)21-22-12)20-17-13-5-6-14(23-3)16(24-4)15(13)18-9-19-17/h5-6,8-10H,7H2,1-4H3,(H,21,22)(H,18,19,20)/t10-/m0/s1 JTROLECZHRVLFM-JTQLQIEISA-N 50272569 CHEMBL4128481 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 42 ChEMBL 10.1021/acs.jmedchem.8b00374 10.7270/Q2J67KDQ 29718668 Humphrey, JM; Movsesian, M; Am Ende, CW; Becker, SL; Chappie, TA; Jenkinson, S; Liras, JL; Liras, S; Orozco, C; Pandit, J; Vajdos, FF; Vandeput, F; Yang, E; Menniti, FS Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50272569 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50272569&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 75815419 405256309 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 50927417 COc1ccc2c(NC(C)Cc3cc(C)[nH]n3)ncnc2c1OC InChI=1S/C17H21N5O2/c1-10(7-12-8-11(2)21-22-12)20-17-13-5-6-14(23-3)16(24-4)15(13)18-9-19-17/h5-6,8-10H,7H2,1-4H3,(H,21,22)(H,18,19,20) JTROLECZHRVLFM-UHFFFAOYSA-N 50272571 CHEMBL4127641 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 118 ChEMBL 10.1021/acs.jmedchem.8b00374 10.7270/Q2J67KDQ 29718668 Humphrey, JM; Movsesian, M; Am Ende, CW; Becker, SL; Chappie, TA; Jenkinson, S; Liras, JL; Liras, S; Orozco, C; Pandit, J; Vajdos, FF; Vandeput, F; Yang, E; Menniti, FS Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50272571 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50272571&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 44180409 405256311 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51114606 COc1cc2CCN(Cc2cc1OC1CCCC1)S(=O)(=O)c1ccc(NC(C)=O)cc1 InChI=1S/C23H28N2O5S/c1-16(26)24-19-7-9-21(10-8-19)31(27,28)25-12-11-17-13-22(29-2)23(14-18(17)15-25)30-20-5-3-4-6-20/h7-10,13-14,20H,3-6,11-12,15H2,1-2H3,(H,24,26) MATVLUWHSFXXRL-UHFFFAOYSA-N 50455384 CHEMBL4206423 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >100000 ChEMBL 10.1016/j.bmcl.2018.02.056 10.7270/Q2W66PBS 29545101 Liao, Y; Guo, Y; Li, S; Wang, L; Tang, Y; Li, T; Chen, W; Zhong, G; Song, G South China Agricultural University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50455384 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50455384&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 145978345 433923500 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51114607 COC(=O)C1Cc2cc(OC)c(OC3CCCC3)cc2CN1C(=O)c1ccc(OC(F)(F)F)cc1 InChI=1S/C25H26F3NO6/c1-32-21-12-16-11-20(24(31)33-2)29(14-17(16)13-22(21)34-18-5-3-4-6-18)23(30)15-7-9-19(10-8-15)35-25(26,27)28/h7-10,12-13,18,20H,3-6,11,14H2,1-2H3 WTHDBTGFIKDFRU-UHFFFAOYSA-N 50455383 CHEMBL4215772 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >100000 ChEMBL 10.1016/j.bmcl.2018.02.056 10.7270/Q2W66PBS 29545101 Liao, Y; Guo, Y; Li, S; Wang, L; Tang, Y; Li, T; Chen, W; Zhong, G; Song, G South China Agricultural University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50455383 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50455383&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 145974174 433923499 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 50819557 CCC(NC(=O)N1CC(=O)Nc2cccnc12)c1ccc(OC(F)(F)F)cc1 InChI=1S/C18H17F3N4O3/c1-2-13(11-5-7-12(8-6-11)28-18(19,20)21)24-17(27)25-10-15(26)23-14-4-3-9-22-16(14)25/h3-9,13H,2,10H2,1H3,(H,23,26)(H,24,27) OZDUBIZEHLUYCU-UHFFFAOYSA-N 50258898 CHEMBL4064344 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 3200 ChEMBL 10.1021/acs.jmedchem.7b00807 10.7270/Q2P271JR 28796496 Mikami, S; Nakamura, S; Ashizawa, T; Nomura, I; Kawasaki, M; Sasaki, S; Oki, H; Kokubo, H; Hoffman, ID; Zou, H; Uchiyama, N; Nakashima, K; Kamiguchi, N; Imada, H; Suzuki, N; Iwashita, H; Taniguchi, T Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50258898 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50258898&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 117949009 402361655 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51140588 CCN1C(=O)[C@H]2Cc3c([nH]c4ccccc34)[C@H](N2C1=O)c1ccc(CC)s1 InChI=1S/C21H21N3O2S/c1-3-12-9-10-17(27-12)19-18-14(13-7-5-6-8-15(13)22-18)11-16-20(25)23(4-2)21(26)24(16)19/h5-10,16,19,22H,3-4,11H2,1-2H3/t16-,19-/m1/s1 PYRZRKTWNHDCON-VQIMIIECSA-N 50467479 CHEMBL4281081 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >20000 ChEMBL 10.1016/j.ejmech.2018.09.028 10.7270/Q2JS9T4N 30245400 Zheng, H; Wu, Y; Sun, B; Cheng, C; Qiao, Y; Jiang, Y; Zhao, S; Xie, Z; Tan, J; Lou, H Shandong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467479&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 141737657 433934744 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51140599 CCc1ccc(s1)[C@@H]1N2[C@@H](Cc3c1[nH]c1ccccc31)C(=O)N(C)CC2=O InChI=1S/C21H21N3O2S/c1-3-12-8-9-17(27-12)20-19-14(13-6-4-5-7-15(13)22-19)10-16-21(26)23(2)11-18(25)24(16)20/h4-9,16,20,22H,3,10-11H2,1-2H3/t16-,20-/m0/s1 WNVDDMMDUVNDAO-JXFKEZNVSA-N 50467485 CHEMBL4283473 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >20000 ChEMBL 10.1016/j.ejmech.2018.09.028 10.7270/Q2JS9T4N 30245400 Zheng, H; Wu, Y; Sun, B; Cheng, C; Qiao, Y; Jiang, Y; Zhao, S; Xie, Z; Tan, J; Lou, H Shandong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467485 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467485&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 141737655 433934750 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51140600 CCN1C(=O)[C@@H]2Cc3c([nH]c4ccccc34)[C@H](N2C1=O)c1sccc1C InChI=1S/C20H19N3O2S/c1-3-22-19(24)15-10-13-12-6-4-5-7-14(12)21-16(13)17(23(15)20(22)25)18-11(2)8-9-26-18/h4-9,15,17,21H,3,10H2,1-2H3/t15-,17-/m0/s1 ZJCXRZRYBPCBNM-RDJZCZTQSA-N 50467486 CHEMBL4285199 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >20000 ChEMBL 10.1016/j.ejmech.2018.09.028 10.7270/Q2JS9T4N 30245400 Zheng, H; Wu, Y; Sun, B; Cheng, C; Qiao, Y; Jiang, Y; Zhao, S; Xie, Z; Tan, J; Lou, H Shandong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467486 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467486&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 141737666 433934751 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51140630 CCCCN1C(=O)[C@H]2Cc3c([nH]c4ccccc34)[C@H](N2C1=O)c1ccc(CC)s1 InChI=1S/C23H25N3O2S/c1-3-5-12-25-22(27)18-13-16-15-8-6-7-9-17(15)24-20(16)21(26(18)23(25)28)19-11-10-14(4-2)29-19/h6-11,18,21,24H,3-5,12-13H2,1-2H3/t18-,21-/m1/s1 MHKSTLAWFJQTLC-WIYYLYMNSA-N 50467487 CHEMBL4291228 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >20000 ChEMBL 10.1016/j.ejmech.2018.09.028 10.7270/Q2JS9T4N 30245400 Zheng, H; Wu, Y; Sun, B; Cheng, C; Qiao, Y; Jiang, Y; Zhao, S; Xie, Z; Tan, J; Lou, H Shandong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467487 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467487&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 141737674 433934752 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51140651 CCc1ccc(o1)[C@H]1N2[C@H](Cc3c1[nH]c1ccccc31)C(=O)N(C)CC2=O InChI=1S/C21H21N3O3/c1-3-12-8-9-17(27-12)20-19-14(13-6-4-5-7-15(13)22-19)10-16-21(26)23(2)11-18(25)24(16)20/h4-9,16,20,22H,3,10-11H2,1-2H3/t16-,20-/m1/s1 QTWIOCLYEVHSLI-OXQOHEQNSA-N 50467484 CHEMBL4281590 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >20000 ChEMBL 10.1016/j.ejmech.2018.09.028 10.7270/Q2JS9T4N 30245400 Zheng, H; Wu, Y; Sun, B; Cheng, C; Qiao, Y; Jiang, Y; Zhao, S; Xie, Z; Tan, J; Lou, H Shandong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467484&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 141737676 433934749 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51140653 CN1CC(=O)N2[C@H](Cc3c([nH]c4ccccc34)[C@H]2c2ccc3OCOc3c2)C1=O InChI=1S/C22H19N3O4/c1-24-10-19(26)25-16(22(24)27)9-14-13-4-2-3-5-15(13)23-20(14)21(25)12-6-7-17-18(8-12)29-11-28-17/h2-8,16,21,23H,9-11H2,1H3/t16-,21-/m1/s1 WOXKDUGGOYFFRN-IIBYNOLFSA-N 14777 (2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.0^{3,8}.0^{11,16}]heptadeca-1(10),11(16),12,14-tetraene-4,7-dione::(6R,12aR)-6-(1,3-benzodioxol-5-yl)-2-methyl-2,3,6,7,12,12a-hexahydropyrazino[1,2,1,6]pyrido[3,4-b]indole-1,4-dione::CHEMBL779::Cialis::GF 196960::Tadalafil Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >10000 ChEMBL 10.1016/j.ejmech.2018.09.028 10.7270/Q2JS9T4N 30245400 Zheng, H; Wu, Y; Sun, B; Cheng, C; Qiao, Y; Jiang, Y; Zhao, S; Xie, Z; Tan, J; Lou, H Shandong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14777 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14777&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search CIA 110635 46515102 71940 CHEMBL779 DB00820 7299 ZINC03993855 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51140725 CN1CC(=O)N2[C@H](Cc3c([nH]c4ccccc34)[C@H]2c2ccc(Br)s2)C1=O InChI=1S/C19H16BrN3O2S/c1-22-9-16(24)23-13(19(22)25)8-11-10-4-2-3-5-12(10)21-17(11)18(23)14-6-7-15(20)26-14/h2-7,13,18,21H,8-9H2,1H3/t13-,18-/m1/s1 KUYGOKWGSHFXJD-FZKQIMNGSA-N 50467474 CHEMBL4289471 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >20000 ChEMBL 10.1016/j.ejmech.2018.09.028 10.7270/Q2JS9T4N 30245400 Zheng, H; Wu, Y; Sun, B; Cheng, C; Qiao, Y; Jiang, Y; Zhao, S; Xie, Z; Tan, J; Lou, H Shandong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467474&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 9802738 433934739 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51140726 CN1CC(=O)N2[C@H](Cc3c([nH]c4ccccc34)[C@H]2c2ccc(C)s2)C1=O InChI=1S/C20H19N3O2S/c1-11-7-8-16(26-11)19-18-13(12-5-3-4-6-14(12)21-18)9-15-20(25)22(2)10-17(24)23(15)19/h3-8,15,19,21H,9-10H2,1-2H3/t15-,19-/m1/s1 LFVBPBWMEWDRAV-DNVCBOLYSA-N 50467490 CHEMBL4278136 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >20000 ChEMBL 10.1016/j.ejmech.2018.09.028 10.7270/Q2JS9T4N 30245400 Zheng, H; Wu, Y; Sun, B; Cheng, C; Qiao, Y; Jiang, Y; Zhao, S; Xie, Z; Tan, J; Lou, H Shandong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467490 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467490&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 141737681 433934755 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51140727 CCc1ccc(s1)[C@H]1N2[C@H](Cc3c1[nH]c1ccccc31)C(=O)N(C)CC2=O InChI=1S/C21H21N3O2S/c1-3-12-8-9-17(27-12)20-19-14(13-6-4-5-7-15(13)22-19)10-16-21(26)23(2)11-18(25)24(16)20/h4-9,16,20,22H,3,10-11H2,1-2H3/t16-,20-/m1/s1 WNVDDMMDUVNDAO-OXQOHEQNSA-N 50467488 CHEMBL4286052 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >20000 ChEMBL 10.1016/j.ejmech.2018.09.028 10.7270/Q2JS9T4N 30245400 Zheng, H; Wu, Y; Sun, B; Cheng, C; Qiao, Y; Jiang, Y; Zhao, S; Xie, Z; Tan, J; Lou, H Shandong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467488 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467488&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 141737696 433934753 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51140728 CCN1C(=O)[C@@H]2Cc3c([nH]c4ccccc34)[C@H](N2C1=O)c1ccc(C)o1 InChI=1S/C20H19N3O3/c1-3-22-19(24)15-10-13-12-6-4-5-7-14(12)21-17(13)18(23(15)20(22)25)16-9-8-11(2)26-16/h4-9,15,18,21H,3,10H2,1-2H3/t15-,18+/m0/s1 QFMUYNLRTWIZJM-MAUKXSAKSA-N 50467473 CHEMBL4292389 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >20000 ChEMBL 10.1016/j.ejmech.2018.09.028 10.7270/Q2JS9T4N 30245400 Zheng, H; Wu, Y; Sun, B; Cheng, C; Qiao, Y; Jiang, Y; Zhao, S; Xie, Z; Tan, J; Lou, H Shandong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467473 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467473&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 141737704 433934738 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51140729 CCN1C(=O)[C@@H]2Cc3c([nH]c4ccccc34)[C@H](N2C1=O)c1ccc(CC)s1 InChI=1S/C21H21N3O2S/c1-3-12-9-10-17(27-12)19-18-14(13-7-5-6-8-15(13)22-18)11-16-20(25)23(4-2)21(26)24(16)19/h5-10,16,19,22H,3-4,11H2,1-2H3/t16-,19+/m0/s1 PYRZRKTWNHDCON-QFBILLFUSA-N 50467477 CHEMBL4277243 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >20000 ChEMBL 10.1016/j.ejmech.2018.09.028 10.7270/Q2JS9T4N 30245400 Zheng, H; Wu, Y; Sun, B; Cheng, C; Qiao, Y; Jiang, Y; Zhao, S; Xie, Z; Tan, J; Lou, H Shandong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467477&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 141737690 433934742 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51140730 CCN1C(=O)[C@H]2Cc3c([nH]c4ccccc34)[C@@H](N2C1=O)c1ccc(CC)o1 InChI=1S/C21H21N3O3/c1-3-12-9-10-17(27-12)19-18-14(13-7-5-6-8-15(13)22-18)11-16-20(25)23(4-2)21(26)24(16)19/h5-10,16,19,22H,3-4,11H2,1-2H3/t16-,19+/m1/s1 VKKJMPZSQBNIOL-APWZRJJASA-N 50467475 CHEMBL4284224 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >20000 ChEMBL 10.1016/j.ejmech.2018.09.028 10.7270/Q2JS9T4N 30245400 Zheng, H; Wu, Y; Sun, B; Cheng, C; Qiao, Y; Jiang, Y; Zhao, S; Xie, Z; Tan, J; Lou, H Shandong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467475 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467475&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 141737703 433934740 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51140731 CCN1C(=O)[C@H]2Cc3c([nH]c4ccccc34)[C@H](N2C1=O)c1ccc(CC)o1 InChI=1S/C21H21N3O3/c1-3-12-9-10-17(27-12)19-18-14(13-7-5-6-8-15(13)22-18)11-16-20(25)23(4-2)21(26)24(16)19/h5-10,16,19,22H,3-4,11H2,1-2H3/t16-,19-/m1/s1 VKKJMPZSQBNIOL-VQIMIIECSA-N 50467491 CHEMBL4289291 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >20000 ChEMBL 10.1016/j.ejmech.2018.09.028 10.7270/Q2JS9T4N 30245400 Zheng, H; Wu, Y; Sun, B; Cheng, C; Qiao, Y; Jiang, Y; Zhao, S; Xie, Z; Tan, J; Lou, H Shandong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467491 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467491&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 141737668 433934756 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51140735 CCN1C(=O)[C@@H]2Cc3c([nH]c4ccccc34)[C@H](N2C1=O)c1ccc(CC)o1 InChI=1S/C21H21N3O3/c1-3-12-9-10-17(27-12)19-18-14(13-7-5-6-8-15(13)22-18)11-16-20(25)23(4-2)21(26)24(16)19/h5-10,16,19,22H,3-4,11H2,1-2H3/t16-,19+/m0/s1 VKKJMPZSQBNIOL-QFBILLFUSA-N 50467472 CHEMBL4281766 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >20000 ChEMBL 10.1016/j.ejmech.2018.09.028 10.7270/Q2JS9T4N 30245400 Zheng, H; Wu, Y; Sun, B; Cheng, C; Qiao, Y; Jiang, Y; Zhao, S; Xie, Z; Tan, J; Lou, H Shandong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467472 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467472&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 141737705 433934737 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51140737 CCCCN1C(=O)[C@@H]2Cc3c([nH]c4ccccc34)[C@H](N2C1=O)c1ccc(CC)s1 InChI=1S/C23H25N3O2S/c1-3-5-12-25-22(27)18-13-16-15-8-6-7-9-17(15)24-20(16)21(26(18)23(25)28)19-11-10-14(4-2)29-19/h6-11,18,21,24H,3-5,12-13H2,1-2H3/t18-,21+/m0/s1 MHKSTLAWFJQTLC-GHTZIAJQSA-N 50467476 CHEMBL4280648 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >20000 ChEMBL 10.1016/j.ejmech.2018.09.028 10.7270/Q2JS9T4N 30245400 Zheng, H; Wu, Y; Sun, B; Cheng, C; Qiao, Y; Jiang, Y; Zhao, S; Xie, Z; Tan, J; Lou, H Shandong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467476 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467476&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 141737667 433934741 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856350 CCOc1ncccc1-c1cc(NCc2nnc(C)o2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C22H27N7O2/c1-6-13(3)29-21-18(24-12-19-27-26-15(5)31-19)11-17(25-20(21)14(4)28-29)16-9-8-10-23-22(16)30-7-2/h8-11,13H,6-7,12H2,1-5H3,(H,24,25) SJDHGTJKQKPRAR-UHFFFAOYSA-N 279092 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(5-methyl-1,3,4-oxadiazol-2-yl)methyl]-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 123::US10034861, Example 124::US10512632, Example 123::US10766893, Example S124::US10806718, Example 124::US11634416, Example 124 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 9.70 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279092&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273419 378160678 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856353 CCOc1ncccc1-c1cc(NCc2cncc(OC)c2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C25H30N6O2/c1-6-16(3)31-24-22(28-14-18-11-19(32-5)15-26-13-18)12-21(29-23(24)17(4)30-31)20-9-8-10-27-25(20)33-7-2/h8-13,15-16H,6-7,14H2,1-5H3,(H,28,29) SYWOKLNWWYOPHL-UHFFFAOYSA-N 279094 5-(2-ethoxy-3-pyridyl)-N-[(5-methoxy-3-pyridyl)methyl]-3-methyl-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 125::US10512632, Example 125::US10766893, Example S125::US10806718, Example 125::US11634416, Example 125 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.000 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279094&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273422 378160679 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856356 CCOc1ncccc1-c1cc(NCc2ccnc(OC)c2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C25H30N6O2/c1-6-16(3)31-24-21(28-15-18-10-12-26-22(13-18)32-5)14-20(29-23(24)17(4)30-31)19-9-8-11-27-25(19)33-7-2/h8-14,16H,6-7,15H2,1-5H3,(H,28,29) JRNBIFGQRNWOKC-UHFFFAOYSA-N 279095 5-(2-ethoxy-3-pyridyl)-N-[(2-methoxy-4-pyridyl)methyl]-3-methyl-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 126::US10512632, Example 126::US10766893, Example S126::US10806718, Example 126::US11634416, Example 126 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 5.40 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279095&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273420 378160680 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856359 CCOc1ncccc1-c1cc(NCc2nnn(C)n2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C21H27N9O/c1-6-13(3)30-20-17(23-12-18-25-28-29(5)27-18)11-16(24-19(20)14(4)26-30)15-9-8-10-22-21(15)31-7-2/h8-11,13H,6-7,12H2,1-5H3,(H,23,24) ULBLNKNNIPTFLN-UHFFFAOYSA-N 279096 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]-N-[(2-methyltetrazol-5-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 127::US10512632, Example 127::US10766893, Example S127::US10806718, Example 127::US11634416, Example 127 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.80 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279096&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273421 378160681 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856362 CCOc1ncccc1-c1cc(NCc2noc(C)n2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C22H27N7O2/c1-6-13(3)29-21-18(24-12-19-25-15(5)31-28-19)11-17(26-20(21)14(4)27-29)16-9-8-10-23-22(16)30-7-2/h8-11,13H,6-7,12H2,1-5H3,(H,24,26) XOIXJVILDWTHEL-UHFFFAOYSA-N 279097 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 128::US10512632, Example 128::US10766893, Example S128::US10806718, Example 128::US11634416, Example 128 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.20 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279097 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279097&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273425 378160682 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856365 CCOc1ncccc1-c1cc(NCc2coc(C)n2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C23H28N6O2/c1-6-14(3)29-22-20(25-12-17-13-31-16(5)26-17)11-19(27-21(22)15(4)28-29)18-9-8-10-24-23(18)30-7-2/h8-11,13-14H,6-7,12H2,1-5H3,(H,25,27) NAPUFLNYEBBQPU-UHFFFAOYSA-N 279098 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(2-methyloxazol-4-yl)methyl]-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 129::US10512632, Example 129::US10766893, Example S129::US10806718, Example 129::US11634416, Example 129 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 11.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279098 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279098&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273423 378160683 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856368 CCOc1ncccc1-c1cc(NCc2c[nH]cn2)c2n(nc(C)c2n1)C(C)CC 279099 5-(2-ethoxy-3-pyridyl)-N-(1H-imidazol-4-ylmethyl)-3-methyl-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 130::US10512632, Example 130::US10766893, Example S130::US10806718, Example 130::US11634416, Example 130 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 11.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279099&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273424 378160684 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856371 CCOc1ncccc1-c1cc(NCc2cc(C)[nH]n2)c2n(nc(C)c2n1)C(C)CC 279100 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]-N-[(5-methyl-1H-pyrazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 131::US10512632, Example 131::US10766893, Example S131::US10806718, Example 131::US11634416, Example 131 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.350 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279100 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279100&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273426 378160685 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856374 CCOc1ncccc1-c1cc(NCc2cn(C)cn2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C23H29N7O/c1-6-15(3)30-22-20(25-12-17-13-29(5)14-26-17)11-19(27-21(22)16(4)28-30)18-9-8-10-24-23(18)31-7-2/h8-11,13-15H,6-7,12H2,1-5H3,(H,25,27) NIXYLBKMUOTNON-UHFFFAOYSA-N 279101 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(1-methylimidazol-4-yl)methyl]-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 132::US10512632, Example 132::US10766893, Example S132::US10806718, Example 132::US11634416, Example 132 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.140 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279101&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273427 378160686 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856377 CCOc1ncccc1-c1cc(NCc2cnc(C)o2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C23H28N6O2/c1-6-14(3)29-22-20(26-13-17-12-25-16(5)31-17)11-19(27-21(22)15(4)28-29)18-9-8-10-24-23(18)30-7-2/h8-12,14H,6-7,13H2,1-5H3,(H,26,27) ZJGPWXQIKUCOGR-UHFFFAOYSA-N 279102 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(2-methyloxazol-5-yl)methyl]-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 133::US10512632, Example 133::US10766893, Example S133::US10806718, Example 133::US11634416, Example 133 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 11.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279102&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273428 378160687 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856380 CCCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C23H30N8O/c1-6-11-32-23-17(9-8-10-24-23)18-12-19(25-13-20-26-14-30(5)29-20)22-21(27-18)16(4)28-31(22)15(3)7-2/h8-10,12,14-15H,6-7,11,13H2,1-5H3,(H,25,27) SXNFSKBWTTYFLI-UHFFFAOYSA-N 279103 3-methyl-1-[1-methylpropyl]-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]-5-(2-propoxy-3-pyridyl)pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 134::US10512632, Example 134::US10766893, Example S134::US10806718, Example 134::US11491140, Example 134::US11634416, Example 134 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.960 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279103&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273429 378160688 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856383 CCCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(nc(C)c2n1)C(C)CC 279104 3-methyl-1-[1-methylpropyl]-5-(2-propoxy-3-pyridyl)-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 135::US10512632, Example 135::US10766893, Example S135::US10806718, Example 135::US11491140, Example 135::US11634416, Example 135 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.90 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279104&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273430 378160689 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856386 CCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(ncc2n1)C(C)CC 279105 5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine, enantiomer 1::US10034861, Example 136::US10034861, Example 137::US10512632, Example 137::US10766893, Example S137::US10806718, Example 137::US11026923, Example 137::US11491140, Example 137::US11634416, Example 137 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 62.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279105&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273431 378160690 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856389 CCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(ncc2n1)C(C)CC 279105 5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine, enantiomer 1::US10034861, Example 136::US10034861, Example 137::US10512632, Example 137::US10766893, Example S137::US10806718, Example 137::US11026923, Example 137::US11491140, Example 137::US11634416, Example 137 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 180 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279105&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273431 378160690 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856392 CCOc1ncccc1-c1cc(NCc2nnc(C)o2)c2n(ncc2n1)C(C)CC InChI=1S/C21H25N7O2/c1-5-13(3)28-20-17(23-12-19-27-26-14(4)30-19)10-16(25-18(20)11-24-28)15-8-7-9-22-21(15)29-6-2/h7-11,13H,5-6,12H2,1-4H3,(H,23,25) BIQGCKNODPBTSC-UHFFFAOYSA-N 279107 5-(2-ethoxy-3-pyridyl)-N-[(5-methyl-1,3,4-oxadiazol-2-yl)methyl]-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 138::US10034861, Example 139::US10512632, Example 139::US10766893, Example S139::US10806718, Example 139::US11026923, Example 139::US11491140, Example 139::US11634416, Example 139 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 93.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279107&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273432 378160691 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856395 CCOc1ncccc1-c1cc(NCc2nnc(C)o2)c2n(ncc2n1)C(C)CC InChI=1S/C21H25N7O2/c1-5-13(3)28-20-17(23-12-19-27-26-14(4)30-19)10-16(25-18(20)11-24-28)15-8-7-9-22-21(15)29-6-2/h7-11,13H,5-6,12H2,1-4H3,(H,23,25) BIQGCKNODPBTSC-UHFFFAOYSA-N 279107 5-(2-ethoxy-3-pyridyl)-N-[(5-methyl-1,3,4-oxadiazol-2-yl)methyl]-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 138::US10034861, Example 139::US10512632, Example 139::US10766893, Example S139::US10806718, Example 139::US11026923, Example 139::US11491140, Example 139::US11634416, Example 139 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 330 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279107&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273432 378160691 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856398 CCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(ncc2n1)C(C)CC InChI=1S/C21H26N8O/c1-5-14(3)29-20-17(23-12-19-24-13-28(4)27-19)10-16(26-18(20)11-25-29)15-8-7-9-22-21(15)30-6-2/h7-11,13-14H,5-6,12H2,1-4H3,(H,23,26) OKQUCPHNAVGTKM-UHFFFAOYSA-N 279109 5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 140::US10034861, Example 141::US10512632, Example 141::US10766893, Example S141::US10806718, Example 141::US11026923, Example 141::US11491140, Example 141::US11634416, Example 141 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 32.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279109&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273433 378160692 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856401 CCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(ncc2n1)C(C)CC InChI=1S/C21H26N8O/c1-5-14(3)29-20-17(23-12-19-24-13-28(4)27-19)10-16(26-18(20)11-25-29)15-8-7-9-22-21(15)30-6-2/h7-11,13-14H,5-6,12H2,1-4H3,(H,23,26) OKQUCPHNAVGTKM-UHFFFAOYSA-N 279109 5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 140::US10034861, Example 141::US10512632, Example 141::US10766893, Example S141::US10806718, Example 141::US11026923, Example 141::US11491140, Example 141::US11634416, Example 141 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 44.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279109&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273433 378160692 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856404 CCCOc1ncccc1-c1cc(NCc2cn(C)cn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H29N7O/c1-6-10-31-23-18(8-7-9-24-23)19-11-20(25-12-17-13-29(5)14-26-17)22-21(27-19)16(4)28-30(22)15(2)3/h7-9,11,13-15H,6,10,12H2,1-5H3,(H,25,27) KLLVPOPJMWWQFO-UHFFFAOYSA-N 279111 1-isopropyl-3-methyl-N-[(1-methylimidazol-4-yl)methyl]-5-(2-propoxy-3-pyridyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 142::US10512632, Example 142::US10766893, Example S142::US10806718, Example 142::US11491140, Example 142::US11634416, Example 142 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.260 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279111&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273434 378160693 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856407 CCCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H27N7O/c1-5-11-30-22-17(7-6-9-23-22)18-12-19(24-13-16-8-10-25-27-16)21-20(26-18)15(4)28-29(21)14(2)3/h6-10,12,14H,5,11,13H2,1-4H3,(H,24,26)(H,25,27) WVFCCHYAETYKIF-UHFFFAOYSA-N 279112 1-isopropyl-3-methyl-5-(2-propoxy-3-pyridyl)-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 143::US10512632, Example 143::US10766893, Example S143::US10806718, Example 143::US11026923, Example 143::US11491140, Example 143::US11634416, Example 143 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 3.80 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279112&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273435 378160694 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856410 CCOc1ncccc1-c1cc(NCc2nc[nH]n2)c2n(nc(C)c2n1)C(C)CC 279113 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]-N-(1H-1,2,4-triazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 144::US10512632, Example 144::US10766893, Example S144::US10806718, Example 144::US11026923, Example 144::US11491140, Example 144::US11634416, Example 144 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 14.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279113&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273438 378160695 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856413 CCCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H28N8O/c1-6-10-31-22-16(8-7-9-23-22)17-11-18(24-12-19-25-13-29(5)28-19)21-20(26-17)15(4)27-30(21)14(2)3/h7-9,11,13-14H,6,10,12H2,1-5H3,(H,24,26) ROWMNTAKQCZGNZ-UHFFFAOYSA-N 279114 1-isopropyl-3-methyl-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]-5-(2-propoxy-3-pyridyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 145::US10512632, Example 145::US10766893, Example S145::US10806718, Example 145::US11026923, Example 145::US11491140, Example 145::US11634416, Example 145 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.410 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279114&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273436 378160696 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856416 CCCOc1ncccc1-c1cc(NCc2nc[nH]n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-5-9-30-21-15(7-6-8-22-21)16-10-17(23-11-18-24-12-25-27-18)20-19(26-16)14(4)28-29(20)13(2)3/h6-8,10,12-13H,5,9,11H2,1-4H3,(H,23,26)(H,24,25,27) RLGQIPCFRYRCDL-UHFFFAOYSA-N 279115 1-isopropyl-3-methyl-5-(2-propoxy-3-pyridyl)-N-(1H-1,2,4-triazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 146::US10512632, Example 146::US10766893, Example S146::US10806718, Example 146::US11026923, Example 146::US11491140, Example 146::US11634416, Example 146 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 3.90 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279115&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273440 378160697 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856419 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1nccs1 InChI=1S/C18H21N7S/c1-11(2)25-17-14(20-8-13-9-21-24(4)10-13)7-15(18-19-5-6-26-18)22-16(17)12(3)23-25/h5-7,9-11H,8H2,1-4H3,(H,20,22) TVGMRVMYCDHOEG-UHFFFAOYSA-N 279116 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-thiazol-2-yl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 147::US10512632, Example 147::US10618913, Example S147::US10766893, Example S147::US10806718, Example 147::US11026923, Example 147::US11491140, Example 147::US11634416, Example 147 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 12.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279116&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273437 378160698 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856422 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1ncc(C)s1 InChI=1S/C19H23N7S/c1-11(2)26-18-15(20-8-14-9-22-25(5)10-14)6-16(19-21-7-12(3)27-19)23-17(18)13(4)24-26/h6-7,9-11H,8H2,1-5H3,(H,20,23) ACZBEPYVSHJPFB-UHFFFAOYSA-N 279117 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-(5-methylthiazol-2-yl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 148::US10512632, Example 148::US10766893, Example S148::US10806718, Example 148::US11026923, Example 148::US11491140, Example 148::US11634416, Example 148 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 110 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279117&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273439 378160699 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856425 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1nc(C)cs1 InChI=1S/C19H23N7S/c1-11(2)26-18-15(20-7-14-8-21-25(5)9-14)6-16(19-22-12(3)10-27-19)23-17(18)13(4)24-26/h6,8-11H,7H2,1-5H3,(H,20,23) HCLONMUJAHJFIH-UHFFFAOYSA-N 279118 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-(4-methylthiazol-2-yl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 149::US10512632, Example 149::US10766893, Example S149::US10806718, Example 149::US11026923, Example 149::US11491140, Example 149::US11634416, Example 149 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 29.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279118&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273441 378160700 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856428 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)N1CC(C)OC1=O InChI=1S/C19H25N7O2/c1-11(2)26-18-15(20-7-14-8-21-24(5)10-14)6-16(22-17(18)13(4)23-26)25-9-12(3)28-19(25)27/h6,8,10-12H,7,9H2,1-5H3,(H,20,22) YBJPEIIVVVNBPC-UHFFFAOYSA-N 279119 3-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]-5-methyl-oxazolidin-2-one::US10034861, Example 150::US10512632, Example 150::US10766893, Example S150::US10806718, Example 150::US11026923, Example 150::US11491140, Example 150::US11634416, Example 150 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 44.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279119&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273442 378160701 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856431 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)N1CCOC1=O InChI=1S/C18H23N7O2/c1-11(2)25-17-14(19-8-13-9-20-23(4)10-13)7-15(21-16(17)12(3)22-25)24-5-6-27-18(24)26/h7,9-11H,5-6,8H2,1-4H3,(H,19,21) CBOOBJUJEUVRPS-UHFFFAOYSA-N 279120 3-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]oxazolidin-2-one::US10034861, Example 151::US10512632, Example 151::US10766893, Example S151::US10806718, Example 151::US11026923, Example 151::US11491140, Example 151::US11634416, Example 151 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 10.00 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279120&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273443 378160702 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856434 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)N1CCC1=O InChI=1S/C18H23N7O/c1-11(2)25-18-14(19-8-13-9-20-23(4)10-13)7-15(24-6-5-16(24)26)21-17(18)12(3)22-25/h7,9-11H,5-6,8H2,1-4H3,(H,19,21) SLJWZSCTWDVJBR-UHFFFAOYSA-N 279121 1-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]azetidin-2-one::US10034861, Example 152::US10512632, Example 152::US10766893, Example S152::US10806718, Example 152::US11026923, Example 152::US11491140, Example 152::US11634416, Example 152 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 48.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279121&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273444 378160703 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856437 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)N1CCN(C1=O)C(C)(C)C InChI=1S/C22H32N8O/c1-14(2)30-20-17(23-11-16-12-24-27(7)13-16)10-18(25-19(20)15(3)26-30)28-8-9-29(21(28)31)22(4,5)6/h10,12-14H,8-9,11H2,1-7H3,(H,23,25) KIFHGJKUXDTDBI-UHFFFAOYSA-N 279122 1-tert-butyl-3-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]imidazolidin-2-one::US10034861, Example 153::US10512632, Example 153::US10766893, Example S153::US10806718, Example 153::US11026923, Example 153::US11491140, Example 153::US11634416, Example 153 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 130 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279122&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273445 378160704 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856440 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)N1CCCC1=O InChI=1S/C19H25N7O/c1-12(2)26-19-15(20-9-14-10-21-24(4)11-14)8-16(22-18(19)13(3)23-26)25-7-5-6-17(25)27/h8,10-12H,5-7,9H2,1-4H3,(H,20,22) CXGJWWJDXYZFFZ-UHFFFAOYSA-N 279123 1-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]pyrrolidin-2-one::US10034861, Example 154::US10512632, Example 154::US10766893, Example S154::US10806718, Example 154::US11026923, Example 154::US11491140, Example 154::US11634416, Example 154 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 26.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279123&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273446 378160705 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856443 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)N1C(C)COC1=O InChI=1S/C19H25N7O2/c1-11(2)26-18-15(20-7-14-8-21-24(5)9-14)6-16(22-17(18)13(4)23-26)25-12(3)10-28-19(25)27/h6,8-9,11-12H,7,10H2,1-5H3,(H,20,22) DXKZTPARVQEQMA-UHFFFAOYSA-N 279124 3-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]-4-methyl-oxazolidin-2-one::US10034861, Example 155::US10512632, Example 155::US10766893, Example S155::US10806718, Example 155::US11026923, Example 155::US11491140, Example 155::US11634416, Example 155 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.20 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279124&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273447 378160706 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856446 CCC1COC(=O)N1c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C20H27N7O2/c1-6-15-11-29-20(28)26(15)17-7-16(21-8-14-9-22-25(5)10-14)19-18(23-17)13(4)24-27(19)12(2)3/h7,9-10,12,15H,6,8,11H2,1-5H3,(H,21,23) CVOILQIVJFYVAQ-UHFFFAOYSA-N 279125 4-ethyl-3-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]oxazolidin-2-one::US10034861, Example 156::US10512632, Example 156::US10766893, Example S156::US10806718, Example 156::US11026923, Example 156::US11491140, Example 156::US11634416, Example 156 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 31.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279125&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273448 378160707 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856449 CCOc1ncccc1-c1cc(CNc2cncc(OC)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-20(8-7-9-26-24)21-10-17(12-27-18-11-19(31-5)14-25-13-18)23-22(28-21)16(4)29-30(23)15(2)3/h7-11,13-15,27H,6,12H2,1-5H3 BXZMPJVMGAVKJS-UHFFFAOYSA-N 279126 N-[[5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-yl]methyl]-5-methoxy-pyridin-3-amine::US10034861, Example 157::US10512632, Example 157::US10766893, Example S157::US10806718, Example 157::US11026923, Example 157::US11491140, Example 157::US11634416, Example 157 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 34.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279126&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273449 378160708 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856452 CCOc1ncccc1-c1cc(CNc2ncn(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-6-30-20-16(8-7-9-22-20)17-10-15(11-23-21-24-12-28(5)27-21)19-18(25-17)14(4)26-29(19)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,23,27) XUAILHHYTLESDG-UHFFFAOYSA-N 279127 N-[[5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-yl]methyl]-1-methyl-1,2,4-triazol-3-amine::US10034861, Example 158::US10512632, Example 158::US10766893, Example S158::US10806718, Example 158::US11026923, Example 158::US11491140, Example 158::US11634416, Example 158 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 23.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279127&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273450 378160709 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856455 CCOc1ncccc1-c1cc(CCc2cncc(OC)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C25H29N5O2/c1-6-32-25-21(8-7-11-27-25)22-13-19(10-9-18-12-20(31-5)15-26-14-18)24-23(28-22)17(4)29-30(24)16(2)3/h7-8,11-16H,6,9-10H2,1-5H3 KRADQTILGMSJGT-UHFFFAOYSA-N 279128 5-(2-ethoxy-3-pyridyl)-1-isopropyl-7-[2-(5-methoxy-3-pyridyl)ethyl]-3-methyl-pyrazolo[4,3-b]pyridine::US10034861, Example 159::US10512632, Example 159::US10766893, Example S159::US10806718, Example 159::US11026923, Example 159::US11491140, Example 159::US11634416, Example 159 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 270 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279128&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273451 378160710 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856458 CCOc1ncccc1-c1cc(CCc2ncn(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H27N7O/c1-6-30-22-17(8-7-11-23-22)18-12-16(9-10-19-24-13-28(5)27-19)21-20(25-18)15(4)26-29(21)14(2)3/h7-8,11-14H,6,9-10H2,1-5H3 DQKKFAGODSQYOO-UHFFFAOYSA-N 279129 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-7-[2-(1-methyl-1,2,4-triazol-3-yl)ethyl]pyrazolo[4,3-b]pyridine::US10034861, Example 160::US10512632, Example 160::US10766893, Example S160::US10806718, Example 160::US11026923, Example 160::US11491140, Example 160::US11634416, Example 160 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 23.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279129&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273452 378160711 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856461 CCOc1ncccc1-c1cc(NCc2ncnn2C)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-6-30-21-15(8-7-9-22-21)16-10-17(23-11-18-24-12-25-28(18)5)20-19(26-16)14(4)27-29(20)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,23,26) DSJWNAKWTOCISO-UHFFFAOYSA-N 425070 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methyl-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10512632, Example 161::US10618913, Example S161::US10766893, Example S161::US10806718, Example 161::US11026923, Example 161::US11491140, Example 162::US11634416, Example 161 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 60.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=425070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=425070&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138536279 434150493 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856464 CCOc1ncccc1-c1cc(NCc2nncn2C)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-6-30-21-15(8-7-9-22-21)16-10-17(23-11-18-26-24-12-28(18)5)20-19(25-16)14(4)27-29(20)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,23,25) XEGYXYUUSUWLRL-UHFFFAOYSA-N 279131 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(4-methyl-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 162::US10512632, Example 162::US10766893, Example S162::US11026923, Example 162::US11634416, Example 162 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 100.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279131&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273453 378160712 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856467 CCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(nc(C)c2n1)C1COC1 InChI=1S/C21H24N8O2/c1-4-31-21-15(6-5-7-22-21)16-8-17(23-9-18-24-12-28(3)27-18)20-19(25-16)13(2)26-29(20)14-10-30-11-14/h5-8,12,14H,4,9-11H2,1-3H3,(H,23,25) KHCSAUOHEOUDEI-UHFFFAOYSA-N 279132 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]-1-(oxetan-3-yl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 163::US10512632, Example 163::US10618913, Example S163::US10766893, Example S163::US10806718, Example 163::US11026923, Example 163::US11491140, Example 163::US11634416, Example 163 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 120 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279132&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273457 378160713 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856470 CCOc1ncccc1-c1cc(SCCC(=O)OCCCCCC(C)C)c2n(nc(C)c2n1)C(C)C InChI=1S/C28H40N4O3S/c1-7-34-28-22(13-11-15-29-28)23-18-24(27-26(30-23)21(6)31-32(27)20(4)5)36-17-14-25(33)35-16-10-8-9-12-19(2)3/h11,13,15,18-20H,7-10,12,14,16-17H2,1-6H3 PCBHYNZWTHLUOA-UHFFFAOYSA-N 425073 US10512632, Example 164 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 6.80 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=425073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=425073&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 140830710 434150494 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856473 CCOc1ncccc1-c1cc(N(Cc2cnn(c2)C(F)F)Cc2ccc(OC)cc2)c2n(nc(C)c2n1)C(C)C InChI=1S/C30H33F2N7O2/c1-6-41-29-24(8-7-13-33-29)25-14-26(28-27(35-25)20(4)36-39(28)19(2)3)37(16-21-9-11-23(40-5)12-10-21)17-22-15-34-38(18-22)30(31)32/h7-15,18-19,30H,6,16-17H2,1-5H3 UXTFTMXAFOTATJ-UHFFFAOYSA-N 279134 N-[[1-(difluoromethyl)pyrazol-4-yl]methyl]-5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 165::US10512632, Example 165::US10618913, Example S165::US11026923, Example 165::US11491140, Example 165::US11634416, Example 165 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 73.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279134&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273284 378160715 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856476 CCOc1ncccc1-c1cc(NCc2cc(CF)on2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H25FN6O2/c1-5-30-22-17(7-6-8-24-22)18-10-19(25-12-15-9-16(11-23)31-28-15)21-20(26-18)14(4)27-29(21)13(2)3/h6-10,13H,5,11-12H2,1-4H3,(H,25,26) XUHFADCPGYKQAR-UHFFFAOYSA-N 279135 5-(2-ethoxy-3-pyridyl)-N-[[5-(fluoromethyl)isoxazol-3-yl]methyl]-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::BDBM425076::US10034861, Example 166::US10512632, Example 166::US10766893, Example S166::US10806718, Example 166::US11026923, Example 166::US11491140, Example 166::US11634416, Example 166 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.10 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279135&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273459 378160716 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856479 CCOc1ncccc1-c1cc(NCc2cc(CF)on2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H25FN6O2/c1-5-30-22-17(7-6-8-24-22)18-10-19(25-12-15-9-16(11-23)31-28-15)21-20(26-18)14(4)27-29(21)13(2)3/h6-10,13H,5,11-12H2,1-4H3,(H,25,26) XUHFADCPGYKQAR-UHFFFAOYSA-N 279135 5-(2-ethoxy-3-pyridyl)-N-[[5-(fluoromethyl)isoxazol-3-yl]methyl]-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::BDBM425076::US10034861, Example 166::US10512632, Example 166::US10766893, Example S166::US10806718, Example 166::US11026923, Example 166::US11491140, Example 166::US11634416, Example 166 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 11.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279135&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273459 378160716 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856482 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1ncco1 InChI=1S/C18H21N7O/c1-11(2)25-17-14(20-8-13-9-21-24(4)10-13)7-15(18-19-5-6-26-18)22-16(17)12(3)23-25/h5-7,9-11H,8H2,1-4H3,(H,20,22) IMKYKBMLZRNQRQ-UHFFFAOYSA-N 279137 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-oxazol-2-yl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 168::US10512632, Example 168::US10618913, Example S168::US10766893, Example S168::US10806718, Example 168::US11026923, Example 168::US11491140, Example 168::US11634416, Example 168 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 14.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279137&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273461 378160718 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856485 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1cnnn1C InChI=1S/C18H23N9/c1-11(2)27-18-15(19-7-13-8-21-25(4)10-13)6-14(16-9-20-24-26(16)5)22-17(18)12(3)23-27/h6,8-11H,7H2,1-5H3,(H,19,22) YPYKZBZKFWCVCN-UHFFFAOYSA-N 279138 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-(3-methyltriazol-4-yl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 169::US10512632, Example 169::US10618913, Example S169::US10766893, Example S169::US10806718, Example 169::US11026923, Example 169::US11491140, Example 169::US11634416, Example 169 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 610 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279138&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273462 378160719 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856488 COc1ncccc1-c1cc(NCc2cccnc2C(F)(F)F)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H23F3N6O/c1-13(2)32-20-18(29-12-15-7-5-9-27-21(15)23(24,25)26)11-17(30-19(20)14(3)31-32)16-8-6-10-28-22(16)33-4/h5-11,13H,12H2,1-4H3,(H,29,30) GLFDPBHOMZCMEF-UHFFFAOYSA-N 279139 1-isopropyl-5-(2-methoxy-3-pyridyl)-3-methyl-N-[[2-(trifluoromethyl)-3-pyridyl]methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 170::US10512632, Example 170::US10766893, Example S170::US10806718, Example 170::US11026923, Example 170::US11491140, Example 170::US11634416, Example 170 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 42.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279139&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273463 378160720 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856491 COc1ncccc1CNc1cc(nc2c(C)nn(C(C)C)c12)-c1ccc[nH]c1=O InChI=1S/C22H24N6O2/c1-13(2)28-20-18(25-12-15-7-5-10-24-22(15)30-4)11-17(26-19(20)14(3)27-28)16-8-6-9-23-21(16)29/h5-11,13H,12H2,1-4H3,(H,23,29)(H,25,26) YJCZMNIYQABZMT-UHFFFAOYSA-N 279140 3-[1-isopropyl-7-[(2-methoxy-3-pyridyl)methylamino]-3-methyl-pyrazolo[4,3-b]pyridin-5-yl]-1H-pyridin-2-one::US10034861, Example 171::US10512632, Example 171::US10766893, Example S171::US10806718, Example 171::US11026923, Example 171::US11491140, Example 171::US11634416, Example 171 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 290 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279140 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279140&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 136214892 378160721 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856494 CCOc1ncccc1-c1cc(NCc2ccncc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(8-7-10-26-24)19-12-20(27-13-17-9-11-25-14-21(17)31-5)23-22(28-19)16(4)29-30(23)15(2)3/h7-12,14-15H,6,13H2,1-5H3,(H,27,28) ZDNREOIUOKDWKN-UHFFFAOYSA-N 425081 US10512632, Example 172::US10766893, Example S172::US10806718, Example 172::US11026923, Example 172::US11491140, Example 172::US11634416, Example 172 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 40.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=425081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=425081&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138535948 434150496 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856497 COc1ncccc1-c1cc(NCc2cnc(C)s2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H24N6OS/c1-12(2)27-20-18(24-11-15-10-23-14(4)29-15)9-17(25-19(20)13(3)26-27)16-7-6-8-22-21(16)28-5/h6-10,12H,11H2,1-5H3,(H,24,25) SVOMGFJYTSFSPH-UHFFFAOYSA-N 279142 1-isopropyl-5-(2-methoxy-3-pyridyl)-3-methyl-N-[(2-methylthiazol-5-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 173::US10512632, Example 173::US10766893, Example S173::US11026923, Example 173::US11491140, Example 173::US11634416, Example 173 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 49.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279142&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273465 378160722 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856500 COc1ncccc1CNc1cc(nc2c(C)nn(C(C)C)c12)-c1cccnc1OC1CC1 InChI=1S/C25H28N6O2/c1-15(2)31-23-21(28-14-17-7-5-11-26-24(17)32-4)13-20(29-22(23)16(3)30-31)19-8-6-12-27-25(19)33-18-9-10-18/h5-8,11-13,15,18H,9-10,14H2,1-4H3,(H,28,29) QLFKDVQWAWXRKU-UHFFFAOYSA-N 279143 5-(2-cyclopropoxypyridin-3-yl)-1-isopropyl-N-((2-methoxypyridin-3-yl)methyl)-3-methyl-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 174::US10512632, Example 174::US10766893, Example S174::US10806718, Example 174::US11026923, Example 174::US11491140, Example 174::US11634416, Example 174 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 18.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279143 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279143&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273466 378160723 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856503 COc1ncccc1CNc1cc(nc2c(C)nn(C(C)C)c12)-c1ccnn1C InChI=1S/C21H25N7O/c1-13(2)28-20-17(23-12-15-7-6-9-22-21(15)29-5)11-16(18-8-10-24-27(18)4)25-19(20)14(3)26-28/h6-11,13H,12H2,1-5H3,(H,23,25) CROUXODBTXNMIZ-UHFFFAOYSA-N 279144 1-isopropyl-N-((2-methoxypyridin-3-yl)methyl)-3-methyl-5-(1-methyl-1H-pyrazol-5-yl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 175::US10512632, Example 175::US10766893, Example S175::US10806718, Example 175::US11026923, Example 175::US11491140, Example 175::US11634416, Example 175 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 83.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279144&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273467 378160724 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856506 CCOc1ncccc1-c1cc(NCc2ncc(OC)cn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O2/c1-6-32-23-17(8-7-9-24-23)18-10-19(25-13-20-26-11-16(31-5)12-27-20)22-21(28-18)15(4)29-30(22)14(2)3/h7-12,14H,6,13H2,1-5H3,(H,25,28) NLZDQEYNQWGPGP-UHFFFAOYSA-N 279145 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(5-methoxypyrimidin-2-yl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 176::US10512632, Example 176::US10766893, Example S176::US10806718, Example 176::US11026923, Example 176::US11491140, Example 176::US11634416, Example 176 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 81.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279145&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273468 378160725 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856509 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1ccc[nH]c1=O InChI=1S/C20H23N7O/c1-12(2)27-19-17(22-9-14-10-23-26(4)11-14)8-16(24-18(19)13(3)25-27)15-6-5-7-21-20(15)28/h5-8,10-12H,9H2,1-4H3,(H,21,28)(H,22,24) ZZXWQIDOSVIHIM-UHFFFAOYSA-N 279146 3-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]-1H-pyridin-2-one::US10034861, Example 177::US10512632, Example 177::US10766893, Example S177::US10806718, Example 177::US11026923, Example 177::US11491140, Example 177::US11634416, Example 177 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 130 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279146&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 136214893 378160726 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856512 CCOc1ncccc1-c1cc(NCc2cccnc2C(F)F)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H26F2N6O/c1-5-33-24-17(9-7-11-28-24)18-12-19(22-20(30-18)15(4)31-32(22)14(2)3)29-13-16-8-6-10-27-21(16)23(25)26/h6-12,14,23H,5,13H2,1-4H3,(H,29,30) IRSHUSVLDQPATB-UHFFFAOYSA-N 279147 N-[[2-(difluoromethyl)-3-pyridyl]methyl]-5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 178::US10512632, Example 178::US10766893, Example S178::US10806718, Example 178::US11026923, Example 178::US11491140, Example 178::US11634416, Example 178 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 31.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279147&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273469 378160727 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856515 CCOc1ncccc1-c1cc(NCc2cc(OC)ncn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O2/c1-6-32-23-17(8-7-9-24-23)18-11-19(25-12-16-10-20(31-5)27-13-26-16)22-21(28-18)15(4)29-30(22)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,25,28) RTCQCKBUFIYEDZ-UHFFFAOYSA-N 279148 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(6-methoxypyrimidin-4-yl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 179::US10512632, Example 179::US10766893, Example S179::US10806718, Example 179::US11026923, Example 179::US11491140, Example 179::US11634416, Example 179 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.80 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279148&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273471 378160728 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856518 CCOc1ncccc1-c1cc(NCc2cccnc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(10-8-12-26-24)19-13-20(27-14-17-9-7-11-25-23(17)31-5)22-21(28-19)16(4)29-30(22)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) LOZUTDKVJLMDTB-UHFFFAOYSA-N 279055 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 172::US10034861, Example 180::US10034861, Example 181::US10034861, Example 182::US10034861, Example 86::US10512632, Example 86::US10766893, Example S86::US10806718, Example 182::US11026923, Example 182::US11491140, Example 86::US11634416, Example 86 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 27.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279055&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273386 378160643 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856521 CCOc1ncccc1-c1cc(NCc2cccnc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(10-8-12-26-24)19-13-20(27-14-17-9-7-11-25-23(17)31-5)22-21(28-19)16(4)29-30(22)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) LOZUTDKVJLMDTB-UHFFFAOYSA-N 279055 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 172::US10034861, Example 180::US10034861, Example 181::US10034861, Example 182::US10034861, Example 86::US10512632, Example 86::US10766893, Example S86::US10806718, Example 182::US11026923, Example 182::US11491140, Example 86::US11634416, Example 86 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 31.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279055&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273386 378160643 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856524 CCOc1ncccc1-c1cc(NCc2cccnc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(10-8-12-26-24)19-13-20(27-14-17-9-7-11-25-23(17)31-5)22-21(28-19)16(4)29-30(22)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) LOZUTDKVJLMDTB-UHFFFAOYSA-N 279055 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 172::US10034861, Example 180::US10034861, Example 181::US10034861, Example 182::US10034861, Example 86::US10512632, Example 86::US10766893, Example S86::US10806718, Example 182::US11026923, Example 182::US11491140, Example 86::US11634416, Example 86 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 24.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279055&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273386 378160643 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856527 COc1ncccc1CNc1cc(nc2c(C)nn(C(C)C)c12)-c1cccnc1C(F)(F)F InChI=1S/C23H23F3N6O/c1-13(2)32-20-18(29-12-15-7-5-10-28-22(15)33-4)11-17(30-19(20)14(3)31-32)16-8-6-9-27-21(16)23(24,25)26/h5-11,13H,12H2,1-4H3,(H,29,30) AAAZUNCZBZHDPM-UHFFFAOYSA-N 279152 1-isopropyl-N-((2-methoxypyridin-3-yl)methyl)-3-methyl-5-(2-(trifluoromethyl)pyridin-3-yl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 183::US10512632, Example 183::US10766893, Example S183::US10806718, Example 183::US11634416, Example 183 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 290 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279152&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273472 378160729 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856530 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C(F)F)c2n1)C(C)C InChI=1S/C22H25F2N7O/c1-5-32-22-15(7-6-8-25-22)16-9-17(26-10-14-11-27-30(4)12-14)20-18(28-16)19(21(23)24)29-31(20)13(2)3/h6-9,11-13,21H,5,10H2,1-4H3,(H,26,28) YFAHCXPQQYYPCW-UHFFFAOYSA-N 279153 3-(difluoromethyl)-5-(2-ethoxypyridin-3-yl)-1-isopropyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 184::US10512632, Example 184::US10618913, Example S184::US10766893, Example S184::US10806718, Example 184::US11491140, Example 184::US11634416, Example 184 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 13.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279153&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273473 378160730 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856533 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-n1cncn1 InChI=1S/C17H21N9/c1-11(2)26-17-14(19-6-13-7-20-24(4)8-13)5-15(25-10-18-9-21-25)22-16(17)12(3)23-26/h5,7-11H,6H2,1-4H3,(H,19,22) VELNJFTUSCXPKE-UHFFFAOYSA-N 279154 1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-5-(1H-1,2,4-triazol-1-yl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 185::US10512632, Example 185::US10766893, Example S185::US10806718, Example 185::US11026923, Example 185::US11491140, Example 185::US11634416, Example 185 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 100.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279154&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273474 378160731 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856536 CC(C)n1nc(C)c2nc(cc(NCc3ncn(C)n3)c12)-c1ccc[nH]c1=O InChI=1S/C19H22N8O/c1-11(2)27-18-15(21-9-16-22-10-26(4)25-16)8-14(23-17(18)12(3)24-27)13-6-5-7-20-19(13)28/h5-8,10-11H,9H2,1-4H3,(H,20,28)(H,21,23) LRKYMHYCQWOGDT-UHFFFAOYSA-N 279155 3-[1-isopropyl-3-methyl-7-[(1-methyl-1,2,4-triazol-3-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]-1H-pyridin-2-one::US10034861, Example 186::US10512632, Example 186::US10766893, Example S186::US10806718, Example 186::US11026923, Example 186::US11491140, Example 186::US11634416, Example 186 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 64.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279155&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 136214894 378160732 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856539 CC(C)n1nc(C)c2nc(cc(NCc3cc[nH]n3)c12)-c1ccc[nH]c1=O InChI=1S/C19H21N7O/c1-11(2)26-18-16(21-10-13-6-8-22-24-13)9-15(23-17(18)12(3)25-26)14-5-4-7-20-19(14)27/h4-9,11H,10H2,1-3H3,(H,20,27)(H,21,23)(H,22,24) FWAXXZSYYYRIBS-UHFFFAOYSA-N 279156 3-[1-isopropyl-3-methyl-7-(1H-pyrazol-3-ylmethylamino)pyrazolo[4,3-b]pyridin-5-yl]-1H-pyridin-2-one::US10034861, Example 187::US10512632, Example 187::US10766893, Example S187::US10806718, Example 187::US11026923, Example 187::US11491140, Example 187::US11634416, Example 187 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 140 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279156&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 136214895 378160733 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856542 COc1ncccc1CNc1cc(nc2c(C)nn(C(C)C)c12)-c1cccnc1OC(F)F InChI=1S/C23H24F2N6O2/c1-13(2)31-20-18(28-12-15-7-5-9-26-21(15)32-4)11-17(29-19(20)14(3)30-31)16-8-6-10-27-22(16)33-23(24)25/h5-11,13,23H,12H2,1-4H3,(H,28,29) HFYVDFFGOVRRIK-UHFFFAOYSA-N 279157 5-[2-(difluoromethoxy)-3-pyridyl]-1-isopropyl-N-[(2-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 188::US10512632, Example 188::US10766893, Example S188::US11026923, Example 188::US11491140, Example 188::US11634416, Example 188 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 61.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279157&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273478 378160734 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856545 CCOc1ncccc1-c1cc(NCc2nccc(OC)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O2/c1-6-32-23-16(8-7-10-25-23)17-12-18(26-13-19-24-11-9-20(28-19)31-5)22-21(27-17)15(4)29-30(22)14(2)3/h7-12,14H,6,13H2,1-5H3,(H,26,27) ZRCQWXKCYCHOGM-UHFFFAOYSA-N 279158 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(4-methoxypyrimidin-2-yl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 189::US10512632, Example 189::US10766893, Example S189::US10806718, Example 189::US11026923, Example 189::US11491140, Example 189::US11634416, Example 189 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 3.90 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279158&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273477 378160735 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856548 CCOc1ncccc1-c1cc(NCc2cncnc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O2/c1-6-32-23-17(8-7-9-25-23)18-10-19(26-12-16-11-24-13-27-22(16)31-5)21-20(28-18)15(4)29-30(21)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,26,28) FQSCOMBJMAVYMG-UHFFFAOYSA-N 279159 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(4-methoxypyrimidin-5-yl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 190::US10512632, Example 190::US10766893, Example S190::US10806718, Example 190::US11026923, Example 190::US11491140, Example 190::US11634416, Example 190 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 74.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279159&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273480 378160736 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856551 CCOc1ncccc1CNc1cc(nc2c(C)nn(C(C)C)c12)-c1cccnc1OCC InChI=1S/C25H30N6O2/c1-6-32-24-18(10-8-12-26-24)15-28-21-14-20(19-11-9-13-27-25(19)33-7-2)29-22-17(5)30-31(16(3)4)23(21)22/h8-14,16H,6-7,15H2,1-5H3,(H,28,29) RPFGIRQWMRKNBU-UHFFFAOYSA-N 279160 5-(2-ethoxy-3-pyridyl)-N-[(2-ethoxy-3-pyridyl)methyl]-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 191::US10512632, Example 191::US10766893, Example S191::US10806718, Example 191::US11026923, Example 191::US11491140, Example 191::US11634416, Example 191 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 160 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279160&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273479 378160737 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856554 COc1ccc(CNc2cc(nc3c(C)nn(C(C)C)c23)-c2cccnc2N(C)C)cc1 InChI=1S/C25H30N6O/c1-16(2)31-24-22(27-15-18-9-11-19(32-6)12-10-18)14-21(28-23(24)17(3)29-31)20-8-7-13-26-25(20)30(4)5/h7-14,16H,15H2,1-6H3,(H,27,28) RMYFPLHNAGFJMC-UHFFFAOYSA-N 279161 5-[2-(dimethylamino)-3-pyridyl]-1-isopropyl-N-[(4-methoxyphenyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 192::US10512632, Example 192::US10766893, Example S192::US10806718, Example 192::US11026923, Example 192::US11491140, Example 192::US11634416, Example 192 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 630 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279161&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273481 378160738 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856557 CC(C)n1nc(C)c2nc(cc(NCc3cccnc3C(F)(F)F)c12)-c1ccc[nH]c1=O InChI=1S/C22H21F3N6O/c1-12(2)31-19-17(28-11-14-6-4-8-26-20(14)22(23,24)25)10-16(29-18(19)13(3)30-31)15-7-5-9-27-21(15)32/h4-10,12H,11H2,1-3H3,(H,27,32)(H,28,29) CEASKHHYUJNGEA-UHFFFAOYSA-N 279162 3-[1-isopropyl-3-methyl-7-[[2-(trifluoromethyl)-3-pyridyl]methylamino]pyrazolo[4,3-b]pyridin-5-yl]-1H-pyridin-2-one::US10034861, Example 193::US10512632, Example 193::US10766893, Example S193::US10806718, Example 193::US11491140, Example 193::US11634416, Example 193 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 320 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279162&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 136214896 378160739 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856560 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1conc1C InChI=1S/C19H23N7O/c1-11(2)26-19-17(20-7-14-8-21-25(5)9-14)6-16(15-10-27-24-12(15)3)22-18(19)13(4)23-26/h6,8-11H,7H2,1-5H3,(H,20,22) MTWLSLCQXJXQNM-UHFFFAOYSA-N 279163 1-isopropyl-3-methyl-5-(3-methylisoxazol-4-yl)-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 194::US10512632, Example 194::US10766893, Example S194::US10806718, Example 194::US11491140, Example 194::US11634416, Example 194 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 95.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279163&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273485 378160740 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856563 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1ncnn1C InChI=1S/C18H23N9/c1-11(2)27-17-14(19-7-13-8-21-25(4)9-13)6-15(18-20-10-22-26(18)5)23-16(17)12(3)24-27/h6,8-11H,7H2,1-5H3,(H,19,23) KYLSIDIKSXHHCI-UHFFFAOYSA-N 279164 1-isopropyl-3-methyl-5-(1-methyl-1H-1,2,4-triazol-5-yl)-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 195::US10512632, Example 195::US10618913, Example S195::US10766893, Example S195::US10806718, Example 195::US11026923, Example 195::US11634416, Example 195 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 420 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279164&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273486 378160741 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 855987 CCOc1ncccc1-c1cc(NCc2nnc(C)o2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H25N7O2/c1-6-29-21-15(8-7-9-22-21)16-10-17(23-11-18-26-25-14(5)30-18)20-19(24-16)13(4)27-28(20)12(2)3/h7-10,12H,6,11H2,1-5H3,(H,23,24) XEBJMVLHZBRKST-UHFFFAOYSA-N 278971 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methyl-1,3,4-oxadiazol-2-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 1::US10512632, Example 1::US10618913, Example S1::US10766893, Example S1::US10806718, Example 1::US11026923, Example 1::US11491140, Example 1::US11634416, Example 1 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 18.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278971 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278971&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273299 378160560 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 855990 CCOc1ncccc1-c1cc(NCc2ncc(C)s2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6OS/c1-6-29-22-16(8-7-9-23-22)17-10-18(24-12-19-25-11-14(4)30-19)21-20(26-17)15(5)27-28(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,24,26) QOYNQFLWGDTXKT-UHFFFAOYSA-N 278972 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methylthiazol-2-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 2::US10512632, Example 2::US10766893, Example S2::US10806718, Example 2::US11026923, Example 2::US11491140, Example 2::US11634416, Example 2 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.460 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278972 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278972&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273301 378160561 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 855993 CCOc1ncccc1-c1cc(NCc2cc(C)on2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6O2/c1-6-29-22-17(8-7-9-23-22)18-11-19(24-12-16-10-14(4)30-27-16)21-20(25-18)15(5)26-28(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,24,25) MKELJWFWEJOZNC-UHFFFAOYSA-N 278973 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methylisoxazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 3::US10512632, Example 3::US10766893, Example S3::US10806718, Example 3::US11026923, Example 3::US11491140, Example 3::US11634416, Example 3 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.800 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278973&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273302 378160562 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 855996 CCOc1ncccc1-c1cc(NCc2cnc(C)o2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6O2/c1-6-29-22-17(8-7-9-23-22)18-10-19(25-12-16-11-24-15(5)30-16)21-20(26-18)14(4)27-28(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,25,26) TWDRBTLHNZMOLP-UHFFFAOYSA-N 278974 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methyloxazol-5-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 4::US10512632, Example 4::US10766893, Example S4::US10806718, Example 4::US11026923, Example 4::US11491140, Example 4::US11634416, Example 4 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.60 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278974 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278974&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273304 378160563 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 855999 CCOc1ncccc1-c1cc(NCc2cnn(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-6-30-21-16(8-7-9-22-21)17-10-18(23-11-15-12-24-28(5)27-15)20-19(25-17)14(4)26-29(20)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,23,25) RKVBYUMNPKGITG-UHFFFAOYSA-N 278975 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methyltriazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 5::US10512632, Example 5::US10766893, Example S5::US10806718, Example 5::US11026923, Example 5::US11491140, Example 5::US11634416, Example 5 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 11.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278975&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273303 378160564 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856002 CCOc1ncccc1-c1cc(NCc2cn(C)nn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-6-30-21-16(8-7-9-22-21)17-10-18(23-11-15-12-28(5)27-25-15)20-19(24-17)14(4)26-29(20)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,23,24) GZZVSCZGHCUFQG-UHFFFAOYSA-N 278976 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(1-methyltriazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 6::US10512632, Example 6::US10766893, Example S6::US10806718, Example 6::US11026923, Example 6::US11491140, Example 6::US11634416, Example 6 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4.80 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278976&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273306 378160565 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856005 CCOc1ncccc1-c1cc(NCc2cn[nH]c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H25N7O/c1-5-29-21-16(7-6-8-22-21)17-9-18(23-10-15-11-24-25-12-15)20-19(26-17)14(4)27-28(20)13(2)3/h6-9,11-13H,5,10H2,1-4H3,(H,23,26)(H,24,25) ZBYZXMQLZZULRF-UHFFFAOYSA-N 278977 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1H-pyrazol-4-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 7::US10512632, Example 7::US10766893, Example S7::US10806718, Example 7::US11026923, Example 7::US11491140, Example 7::US11634416, Example 7 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 21.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278977 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278977&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 136214891 378160566 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856008 CCOc1ncccc1-c1cc(NCc2nnn(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C20H25N9O/c1-6-30-20-14(8-7-9-21-20)15-10-16(22-11-17-24-27-28(5)26-17)19-18(23-15)13(4)25-29(19)12(2)3/h7-10,12H,6,11H2,1-5H3,(H,22,23) MMFBNAADCPOKBP-UHFFFAOYSA-N 278978 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methyltetrazol-5-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 8::US10512632, Example 8::US10766893, Example S8::US10806718, Example 8::US11491140, Example 8::US11634416, Example 8 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.90 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278978&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273308 378160567 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856011 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H27N7O/c1-6-30-22-17(8-7-9-23-22)18-10-19(24-11-16-12-25-28(5)13-16)21-20(26-18)15(4)27-29(21)14(2)3/h7-10,12-14H,6,11H2,1-5H3,(H,24,26) IGZQEXMDAKABFO-UHFFFAOYSA-N 278979 5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 9::US10512632, Example 9::US10766893, Example S9::US10806718, Example 9::US11491140, Example 9::US11634416, Example 9 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.60 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278979&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273307 378160568 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856014 CCOc1ncccc1-c1cc(NCc2cc(C)no2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6O2/c1-6-29-22-17(8-7-9-23-22)18-11-19(24-12-16-10-14(4)27-30-16)21-20(25-18)15(5)26-28(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,24,25) WAUSGEZRVANNBG-UHFFFAOYSA-N 278980 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(3-methylisoxazol-5-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 10::US10512632, Example 10::US10766893, Example S10::US10806718, Example 10::US11491140, Example 10::US11634416, Example 10 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4.10 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278980 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278980&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273310 378160569 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856017 CCOc1ncccc1-c1cc(NCc2csc(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6OS/c1-6-29-22-17(8-7-9-23-22)18-10-19(24-11-16-12-30-15(5)25-16)21-20(26-18)14(4)27-28(21)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,24,26) YDCVOKZJZPJMKM-UHFFFAOYSA-N 278981 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methylthiazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 11::US10512632, Example 11::US10766893, Example S11::US10806718, Example 11::US11491140, Example 11::US11634416, Example 11 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 9.60 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278981&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273309 378160570 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856020 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C1CC1 InChI=1S/C22H25N7O/c1-4-30-22-17(6-5-9-23-22)18-10-19(24-11-15-12-25-28(3)13-15)21-20(26-18)14(2)27-29(21)16-7-8-16/h5-6,9-10,12-13,16H,4,7-8,11H2,1-3H3,(H,24,26) SVNBZNOJEMDHHP-UHFFFAOYSA-N 278982 1-cyclopropyl-5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 12::US10512632, Example 12::US10618913, Example S12::US10766893, Example S12::US10806718, Example 12::US11026923, Example 12::US11491140, Example 12 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 200 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278982&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273311 378160571 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856023 CCCn1ncc2nc(cc(NCc3cnn(C)c3)c12)-c1cccnc1OCC InChI=1S/C21H25N7O/c1-4-9-28-20-18(23-11-15-12-24-27(3)14-15)10-17(26-19(20)13-25-28)16-7-6-8-22-21(16)29-5-2/h6-8,10,12-14H,4-5,9,11H2,1-3H3,(H,23,26) VBBYLKGVLRZVDT-UHFFFAOYSA-N 278983 5-(2-ethoxy-3-pyridyl)-N-[(1-methylpyrazol-4-yl)methyl]-1-propyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 13::US10512632, Example 13::US10618913, Example S13::US10766893, Example S13::US10806718, Example 13::US11026923, Example 13::US11491140, Example 13::US11634416, Example 13 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 90.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278983 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278983&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273312 378160572 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856026 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(ncc2n1)C1COC1 InChI=1S/C21H23N7O2/c1-3-30-21-16(5-4-6-22-21)17-7-18(23-8-14-9-24-27(2)11-14)20-19(26-17)10-25-28(20)15-12-29-13-15/h4-7,9-11,15H,3,8,12-13H2,1-2H3,(H,23,26) BRAWZTIBDHEBNS-UHFFFAOYSA-N 278984 5-(2-ethoxypyridin-3-yl)-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1-(oxetan-3-yl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 14::US10512632, Example 14::US10618913, Example S14::US10766893, Example S14::US10806718, Example 14::US11026923, Example 14::US11491140, Example 14::US11634416, Example 14 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 450 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278984 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278984&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273313 378160573 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856029 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(C)ncc2n1 InChI=1S/C19H21N7O/c1-4-27-19-14(6-5-7-20-19)15-8-16(18-17(24-15)11-23-26(18)3)21-9-13-10-22-25(2)12-13/h5-8,10-12H,4,9H2,1-3H3,(H,21,24) IHPVHEUBCHVJEQ-UHFFFAOYSA-N 278986 5-(2-ethoxypyridin-3-yl)-1-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 16::US10512632, Example 16::US10766893, Example S16::US10806718, Example 16::US11026923, Example 16::US11491140, Example 16 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 670 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278986&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273315 378160575 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856032 CCOc1ncccc1-c1cc(NCc2nccn2C)c2n(ncc2n1)C(C)C InChI=1S/C21H25N7O/c1-5-29-21-15(7-6-8-23-21)16-11-17(24-13-19-22-9-10-27(19)4)20-18(26-16)12-25-28(20)14(2)3/h6-12,14H,5,13H2,1-4H3,(H,24,26) XRIYYPDCPKIHRW-UHFFFAOYSA-N 278987 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimidazol-2-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 17::US10512632, Example 17::US10618913, Example S17::US10766893, Example S17::US10806718, Example 17::US11026923, Example 17::US11491140, Example 17::US11634416, Example 17 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 700 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278987 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278987&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273316 378160576 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856035 CCOc1ncccc1-c1cc(NCc2ccnn2C)c2n(ncc2n1)C(C)C InChI=1S/C21H25N7O/c1-5-29-21-16(7-6-9-22-21)17-11-18(23-12-15-8-10-24-27(15)4)20-19(26-17)13-25-28(20)14(2)3/h6-11,13-14H,5,12H2,1-4H3,(H,23,26) ARZYUJKMHFQSRW-UHFFFAOYSA-N 278988 5-(2-ethoxypyridin-3-yl)-1-isopropyl-N-((1-methyl-1H-pyrazol-5-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 18::US10512632, Example 18::US10766893, Example S18::US10806718, Example 18::US11026923, Example 18::US11491140, Example 18::US11634416, Example 18 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 450 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278988&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273317 378160577 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856038 CCOc1ncccc1-c1cc(NCc2ccn(C)n2)c2n(ncc2n1)C(C)C InChI=1S/C21H25N7O/c1-5-29-21-16(7-6-9-22-21)17-11-18(23-12-15-8-10-27(4)26-15)20-19(25-17)13-24-28(20)14(2)3/h6-11,13-14H,5,12H2,1-4H3,(H,23,25) KZFYUJZMDBTCDC-UHFFFAOYSA-N 278989 5-(2-ethoxypyridin-3-yl)-1-isopropyl-N-((1-methyl-1H-pyrazol-3-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 19::US10512632, Example 19::US10766893, Example S19::US10806718, Example 19::US11026923, Example 19::US11491140, Example 19::US11634416, Example 19 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 66.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278989 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278989&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273318 378160578 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856041 CCOc1ncccc1-c1cc(NCc2nccs2)c2n(ncc2n1)C(C)C InChI=1S/C20H22N6OS/c1-4-27-20-14(6-5-7-22-20)15-10-16(23-12-18-21-8-9-28-18)19-17(25-15)11-24-26(19)13(2)3/h5-11,13H,4,12H2,1-3H3,(H,23,25) ICTYYJZHJNSZFG-UHFFFAOYSA-N 278990 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-(thiazol-2-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 20::US10512632, Example 20::US10766893, Example S20::US10806718, Example 20::US11026923, Example 20::US11491140, Example 20::US11634416, Example 20 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 520 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278990&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273319 378160579 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856044 CCOc1ncccc1-c1cc(NCc2cn(C)cn2)c2n(ncc2n1)C(C)C InChI=1S/C21H25N7O/c1-5-29-21-16(7-6-8-22-21)17-9-18(23-10-15-12-27(4)13-24-15)20-19(26-17)11-25-28(20)14(2)3/h6-9,11-14H,5,10H2,1-4H3,(H,23,26) GPZPPQFWVLHHBU-UHFFFAOYSA-N 278991 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimidazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 21::US10512632, Example 21::US10766893, Example S21::US10806718, Example 21::US11026923, Example 21::US11491140, Example 21::US11634416, Example 21 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.90 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278991&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273320 378160580 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856047 CCOc1ncccc1-c1cc(NCc2ccncc2)c2n(ncc2n1)C(C)C InChI=1S/C22H24N6O/c1-4-29-22-17(6-5-9-24-22)18-12-19(25-13-16-7-10-23-11-8-16)21-20(27-18)14-26-28(21)15(2)3/h5-12,14-15H,4,13H2,1-3H3,(H,25,27) HEERUKANWGHTOL-UHFFFAOYSA-N 278992 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-(4-pyridylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 22::US10512632, Example 22::US10766893, Example S22::US10806718, Example 22::US11026923, Example 22::US11491140, Example 22::US11634416, Example 22 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 250 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278992&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273322 378160581 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856050 CCOc1ncccc1-c1cc(NCc2cccc(C)c2)c2n(ncc2n1)C(C)C InChI=1S/C24H27N5O/c1-5-30-24-19(10-7-11-25-24)20-13-21(26-14-18-9-6-8-17(4)12-18)23-22(28-20)15-27-29(23)16(2)3/h6-13,15-16H,5,14H2,1-4H3,(H,26,28) NOGPVEPEDSPNHF-UHFFFAOYSA-N 278993 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-(m-tolylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 23::US10512632, Example 23::US10618913, Example S23::US10766893, Example S23::US10806718, Example 23::US11026923, Example 23::US11491140, Example 23::US11634416, Example 23 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 240 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278993&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273321 378160582 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856053 CCOc1ncccc1-c1cc(NCc2ccc(C)cc2)c2n(ncc2n1)C(C)C InChI=1S/C24H27N5O/c1-5-30-24-19(7-6-12-25-24)20-13-21(26-14-18-10-8-17(4)9-11-18)23-22(28-20)15-27-29(23)16(2)3/h6-13,15-16H,5,14H2,1-4H3,(H,26,28) KLXXAXDPPNWJOU-UHFFFAOYSA-N 278994 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-(p-tolylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 24::US10512632, Example 24::US10766893, Example S24::US10806718, Example 24::US11026923, Example 24::US11491140, Example 24::US11634416, Example 24 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 380 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278994&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273323 378160583 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856056 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(ncc2n1)C(C)C InChI=1S/C21H25N7O/c1-5-29-21-16(7-6-8-22-21)17-9-18(23-10-15-11-24-27(4)13-15)20-19(26-17)12-25-28(20)14(2)3/h6-9,11-14H,5,10H2,1-4H3,(H,23,26) PLERDTYSXFBCOL-UHFFFAOYSA-N 278995 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 25::US10512632, Example 25::US10766893, Example S25::US10806718, Example 25::US11026923, Example 25::US11491140, Example 25::US11634416, Example 25 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 56.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278995&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273324 378160584 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856059 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(CC)ncc2n1 InChI=1S/C20H23N7O/c1-4-27-19-17(22-10-14-11-23-26(3)13-14)9-16(25-18(19)12-24-27)15-7-6-8-21-20(15)28-5-2/h6-9,11-13H,4-5,10H2,1-3H3,(H,22,25) GDQVLYVPAWKIKI-UHFFFAOYSA-N 424936 US10512632, Example 26::US10618913, Example S26::US10766893, Example S26::US10806718, Example 26::US11026923, Example 26::US11491140, Example 26::US11634416, Example 26 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 140 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=424936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=424936&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138536209 434150491 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856062 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C1COC1 InChI=1S/C22H25N7O2/c1-4-31-22-17(6-5-7-23-22)18-8-19(24-9-15-10-25-28(3)11-15)21-20(26-18)14(2)27-29(21)16-12-30-13-16/h5-8,10-11,16H,4,9,12-13H2,1-3H3,(H,24,26) HKTCICUQHUTDJM-UHFFFAOYSA-N 278997 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-1-(oxetan-3-yl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 27::US10512632, Example 27::US10766893, Example S27::US10806718, Example 27::US11026923, Example 27::US11491140, Example 27::US11634416, Example 27 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 94.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278997 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278997&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273326 378160586 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856065 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(C)nc(C)c2n1 InChI=1S/C20H23N7O/c1-5-28-20-15(7-6-8-21-20)16-9-17(22-10-14-11-23-26(3)12-14)19-18(24-16)13(2)25-27(19)4/h6-9,11-12H,5,10H2,1-4H3,(H,22,24) GGQMHLLGYDUHDQ-UHFFFAOYSA-N 278998 5-(2-ethoxy-3-pyridyl)-1,3-dimethyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 28::US10512632, Example 28::US10618913, Example S28::US10766893, Example S28::US10806718, Example 28::US11026923, Example 28::US11491140, Example 28::US11634416, Example 28 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 550 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278998 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278998&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273327 378160587 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856068 CCOc1ncccc1-c1cc(NCc2nc(C)cs2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6OS/c1-6-29-22-16(8-7-9-23-22)17-10-18(24-11-19-25-14(4)12-30-19)21-20(26-17)15(5)27-28(21)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,24,26) WFSFSRAGPIZNCC-UHFFFAOYSA-N 278999 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(4-methylthiazol-2-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 29::US10512632, Example 29::US10618913, Example S162::US10766893, Example S29::US10806718, Example 29::US11026923, Example 29::US11491140, Example 29::US11634416, Example 29 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 27.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278999 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278999&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273328 378160588 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856071 CCOc1ncccc1-c1cc(NCc2nc(C)no2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H25N7O2/c1-6-29-21-15(8-7-9-22-21)16-10-17(23-11-18-24-14(5)27-30-18)20-19(25-16)13(4)26-28(20)12(2)3/h7-10,12H,6,11H2,1-5H3,(H,23,25) ZPMKSBYSMXCOIZ-UHFFFAOYSA-N 279000 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(3-methyl-1,2,4-oxadiazol-5-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 30::US10512632, Example 30::US10766893, Example S30::US10806718, Example 30::US11026923, Example 30::US11491140, Example 30::US11634416, Example 30 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 15.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279000 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279000&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273329 378160589 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856074 CCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-6-30-21-15(8-7-9-22-21)16-10-17(23-11-18-24-12-28(5)27-18)20-19(25-16)14(4)26-29(20)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,23,25) CJOUFKUESMXTOX-UHFFFAOYSA-N 279001 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 161::US10034861, Example 31::US10512632, Example 31::US10766893, Example S31::US10806718, Example 31::US11026923, Example 31::US11491140, Example 31::US11634416, Example 31 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.20 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279001 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279001&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273330 378160590 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856077 CCOc1ncccc1-c1cc(NCc2cnc(C)s2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6OS/c1-6-29-22-17(8-7-9-23-22)18-10-19(25-12-16-11-24-15(5)30-16)21-20(26-18)14(4)27-28(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,25,26) UJFBEAPRUYBIKE-UHFFFAOYSA-N 279002 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methylthiazol-5-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 32::US10512632, Example 32::US10766893, Example S32::US10806718, Example 32::US11026923, Example 32::US11491140, Example 32::US11634416, Example 32 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4.60 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279002&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273331 378160591 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856080 CCOc1ncccc1-c1cc(NCc2nnc(C)s2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H25N7OS/c1-6-29-21-15(8-7-9-22-21)16-10-17(23-11-18-26-25-14(5)30-18)20-19(24-16)13(4)27-28(20)12(2)3/h7-10,12H,6,11H2,1-5H3,(H,23,24) XQUFGMNXDPCXMM-UHFFFAOYSA-N 279003 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methyl-1,3,4-thiadiazol-2-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 33::US10512632, Example 33::US10766893, Example S33::US10806718, Example 33::US11026923, Example 33::US11491140, Example 33::US11634416, Example 33 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.60 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279003 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279003&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273332 378160592 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856083 CCOc1ncccc1-c1cc(NCc2csc(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N5OS/c1-6-29-23-18(8-7-9-24-23)19-11-20(25-12-17-10-15(4)30-13-17)22-21(26-19)16(5)27-28(22)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,25,26) VNCLCBKVWWHCAF-UHFFFAOYSA-N 279004 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methyl-3-thienyl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 34::US10512632, Example 34::US10766893, Example S34::US10806718, Example 34::US11026923, Example 34::US11491140, Example 34::US11634416, Example 34 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.10 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279004 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279004&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273333 378160593 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856086 CCOc1ncccc1-c1cc(NCc2cc(C)cs2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N5OS/c1-6-29-23-18(8-7-9-24-23)19-11-20(25-12-17-10-15(4)13-30-17)22-21(26-19)16(5)27-28(22)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,25,26) DHODKXCCORNYHA-UHFFFAOYSA-N 279005 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(4-methyl-2-thienyl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 35::US10512632, Example 35::US10766893, Example S35::US10806718, Example 35::US11026923, Example 35::US11491140, Example 35::US11634416, Example 35 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 7.30 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279005 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279005&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273334 378160594 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856089 CCOc1ncccc1-c1cc(NCc2ccc(C)s2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N5OS/c1-6-29-23-18(8-7-11-24-23)19-12-20(25-13-17-10-9-15(4)30-17)22-21(26-19)16(5)27-28(22)14(2)3/h7-12,14H,6,13H2,1-5H3,(H,25,26) MXNGXYQZCMFPJD-UHFFFAOYSA-N 279006 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methyl-2-thienyl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 36::US10512632, Example 36::US10766893, Example S36::US10806718, Example 36::US11026923, Example 36::US11491140, Example 36::US11634416, Example 36 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 24.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279006&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273337 378160595 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856092 CCOc1ncccc1-c1cc(NCc2coc(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6O2/c1-6-29-22-17(8-7-9-23-22)18-10-19(24-11-16-12-30-15(5)25-16)21-20(26-18)14(4)27-28(21)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,24,26) VZTGUNQMZSOPTA-UHFFFAOYSA-N 279007 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methyloxazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 37::US10512632, Example 37::US10766893, Example S37::US10806718, Example 37::US11026923, Example 37::US11491140, Example 37::US11634416, Example 37 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 5.90 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279007 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279007&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273335 378160596 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856095 CCOc1ncccc1-c1cc(NCc2ncc(C)o2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6O2/c1-6-29-22-16(8-7-9-23-22)17-10-18(24-12-19-25-11-14(4)30-19)21-20(26-17)15(5)27-28(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,24,26) IGMSFVIKHQRGSP-UHFFFAOYSA-N 279008 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methyloxazol-2-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 38::US10512632, Example 38::US10766893, Example S38::US10806718, Example 38::US11026923, Example 38::US11491140, Example 38::US11634416, Example 38 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.10 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279008 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279008&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273338 378160597 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856098 CCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H25N7O/c1-5-29-21-16(7-6-9-22-21)17-11-18(23-12-15-8-10-24-26-15)20-19(25-17)14(4)27-28(20)13(2)3/h6-11,13H,5,12H2,1-4H3,(H,23,25)(H,24,26) UOWVOVPKNPTQQH-UHFFFAOYSA-N 279009 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 39::US10512632, Example 39::US10766893, Example S39::US10806718, Example 39::US11026923, Example 39::US11491140, Example 39::US11634416, Example 39 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.10 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279009 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279009&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273340 378160598 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856101 CCOc1ncccc1-c1cc(NCc2c[nH]cn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H25N7O/c1-5-29-21-16(7-6-8-23-21)17-9-18(24-11-15-10-22-12-25-15)20-19(26-17)14(4)27-28(20)13(2)3/h6-10,12-13H,5,11H2,1-4H3,(H,22,25)(H,24,26) IQIUSKXHLPBBOV-UHFFFAOYSA-N 279010 5-(2-ethoxy-3-pyridyl)-N-(1H-imidazol-4-ylmethyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 40::US10512632, Example 40::US10766893, Example S40::US10806718, Example 40::US11026923, Example 40::US11491140, Example 40::US11634416, Example 40 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 14.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279010 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279010&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273339 378160599 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856104 CCOc1ncccc1-c1cc(NCc2ccccc2)c2n(ncc2n1)C(C)C InChI=1S/C23H25N5O/c1-4-29-23-18(11-8-12-24-23)19-13-20(25-14-17-9-6-5-7-10-17)22-21(27-19)15-26-28(22)16(2)3/h5-13,15-16H,4,14H2,1-3H3,(H,25,27) CAHURFTWFHHOPU-UHFFFAOYSA-N 279011 N-benzyl-5-(2-ethoxy-3-pyridyl)-1-isopropyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 41::US10512632, Example 41::US10618913, Example S41::US10766893, Example S41::US10806718, Example 41::US11026923, Example 41::US11634416, Example 41 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 500 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279011 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279011&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273336 378160600 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856107 CCOc1ncccc1-c1cc(NCc2cc(C)no2)c2n(ncc2n1)C(C)C InChI=1S/C21H24N6O2/c1-5-28-21-16(7-6-8-22-21)17-10-18(23-11-15-9-14(4)26-29-15)20-19(25-17)12-24-27(20)13(2)3/h6-10,12-13H,5,11H2,1-4H3,(H,23,25) ZGFGKVRUAVJQMR-UHFFFAOYSA-N 279012 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(3-methylisoxazol-5-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 42::US10512632, Example 42::US10766893, Example S42::US10806718, Example 42::US11026923, Example 42::US11634416, Example 42 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 82.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279012&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273341 378160601 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856110 CCOc1ncccc1-c1cc(NCc2noc(C)n2)c2n(ncc2n1)C(C)C InChI=1S/C20H23N7O2/c1-5-28-20-14(7-6-8-21-20)15-9-16(22-11-18-24-13(4)29-26-18)19-17(25-15)10-23-27(19)12(2)3/h6-10,12H,5,11H2,1-4H3,(H,22,25) SDTZIRBETDMBLS-UHFFFAOYSA-N 279013 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 43::US10512632, Example 43::US10766893, Example S43::US10806718, Example 43::US11026923, Example 43::US11634416, Example 43 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 30.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279013&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273344 378160602 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856113 CCOc1ncccc1-c1cc(NCc2cc(C)n(C)n2)c2n(ncc2n1)C(C)C InChI=1S/C22H27N7O/c1-6-30-22-17(8-7-9-23-22)18-11-19(24-12-16-10-15(4)28(5)27-16)21-20(26-18)13-25-29(21)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,24,26) RWTZKAWRGHZQKR-UHFFFAOYSA-N 279014 N-[(1,5-dimethylpyrazol-3-yl)methyl]-5-(2-ethoxy-3-pyridyl)-1-isopropyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 44::US10512632, Example 44::US10766893, Example S44::US10806718, Example 44::US11026923, Example 44::US11634416, Example 44 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 19.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279014 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279014&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273342 378160603 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856116 CCOc1ncccc1-c1cc(NCc2ccc(=O)n(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(8-7-11-25-24)19-12-20(26-13-17-9-10-21(31)29(5)14-17)23-22(27-19)16(4)28-30(23)15(2)3/h7-12,14-15H,6,13H2,1-5H3,(H,26,27) IFSZKCSGKSFXTM-UHFFFAOYSA-N 279015 3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4-yl)methyl)amino)-1H-pyrazolo[4,3-b]pyridin-5-yl)-1-methylpyridin-2(1H)-one::US10034861, Example 45::US10512632, Example 45::US10806718, Example 45::US11026923, Example 45::US11491140, Example 45::US11634416, Example 45 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.00 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279015 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279015&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273343 378160604 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856119 CCOc1ncccc1-c1cc(NCc2c[nH]c(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H27N7O/c1-6-30-22-17(8-7-9-23-22)18-10-19(25-12-16-11-24-15(5)26-16)21-20(27-18)14(4)28-29(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,24,26)(H,25,27) OESORFJHOJQXKR-UHFFFAOYSA-N 279016 5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((2-methyl-1H-imidazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 46::US10512632, Example 46::US10766893, Example S46::US10806718, Example 46::US11026923, Example 46::US11491140, Example 46::US11634416, Example 46 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 5.00 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279016&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273345 378160605 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856122 CCOc1ncccc1-c1cc(NCc2cc(C)[nH]n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H27N7O/c1-6-30-22-17(8-7-9-23-22)18-11-19(24-12-16-10-14(4)26-27-16)21-20(25-18)15(5)28-29(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,24,25)(H,26,27) BKIZQOUWXXJIIE-UHFFFAOYSA-N 279017 5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((5-methyl-1H-pyrazol-3-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 47::US10512632, Example 47::US10766893, Example S54::US10806718, Example 47::US11026923, Example 47::US11491140, Example 47::US11634416, Example 47 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.60 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279017&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273346 378160606 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856125 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(CC)nc(C)c2n1 InChI=1S/C21H25N7O/c1-5-28-20-18(23-11-15-12-24-27(4)13-15)10-17(25-19(20)14(3)26-28)16-8-7-9-22-21(16)29-6-2/h7-10,12-13H,5-6,11H2,1-4H3,(H,23,25) ALQSQGPOANFHOP-UHFFFAOYSA-N 279018 5-(2-ethoxypyridin-3-yl)-1-ethyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 48::US10512632, Example 48::US10618913, Example S48::US10766893, Example S48::US10806718, Example 48::US11026923, Example 48::US11491140, Example 48::US11634416, Example 48 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 38.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279018&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273347 378160607 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856128 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1cccn(C)c1=O InChI=1S/C21H25N7O/c1-13(2)28-20-18(22-10-15-11-23-27(5)12-15)9-17(24-19(20)14(3)25-28)16-7-6-8-26(4)21(16)29/h6-9,11-13H,10H2,1-5H3,(H,22,24) MRQVRXHGMURIIP-UHFFFAOYSA-N 279019 3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4-yl)methyl)amino)-1H-pyrazolo[4,3-b]pyridin-5-yl)-1-methylpyridin-2(1H)-one::US10034861, Example 49::US10512632, Example 49::US10766893, Example S49::US10806718, Example 49::US11026923, Example 49::US11491140, Example 49::US11634416, Example 49 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 170 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279019 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279019&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273348 378160608 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856131 CCOc1ncccc1-c1cc(NCc2nc(C)co2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6O2/c1-6-29-22-16(8-7-9-23-22)17-10-18(24-11-19-25-14(4)12-30-19)21-20(26-17)15(5)27-28(21)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,24,26) LWOWQQZYEXAZTD-UHFFFAOYSA-N 279020 5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((4-methyloxazol-2-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine 2,2,2-trifluoroacetate::US10034861, Example 50::US10512632, Example 50::US10766893, Example S50::US10806718, Example 50::US11026923, Example 50::US11491140, Example 50::US11634416, Example 50 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 9.00 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279020 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279020&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273350 378160609 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856134 CCOc1ncccc1-c1cc(NCc2cn(C)c(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H29N7O/c1-7-31-23-18(9-8-10-24-23)19-11-20(25-12-17-13-29(6)16(5)26-17)22-21(27-19)15(4)28-30(22)14(2)3/h8-11,13-14H,7,12H2,1-6H3,(H,25,27) RIBLUNUCLUPFGL-UHFFFAOYSA-N 279021 N-((1,2-dimethyl-1H-imidazol-4-yl)methyl)-5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-1H-pyrazolo[4,3-b]pyridin-7-amine 2,2,2-trifluoroacetate::US10034861, Example 51::US10512632, Example 51::US10766893, Example S51::US10806718, Example 51::US11026923, Example 51::US11491140, Example 51::US11634416, Example 51 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 53.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279021 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279021&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273354 378160610 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856137 CCOc1ncccc1-c1cc(NCc2noc(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H25N7O2/c1-6-29-21-15(8-7-9-22-21)16-10-17(23-11-18-24-14(5)30-27-18)20-19(25-16)13(4)26-28(20)12(2)3/h7-10,12H,6,11H2,1-5H3,(H,23,25) GALBTAGDVOLYTK-UHFFFAOYSA-N 279022 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 52::US10512632, Example 52::US10766893, Example S52::US10806718, Example 52::US11026923, Example 52::US11491140, Example 52 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.90 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279022 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279022&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273351 378160611 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856140 CCOc1ncccc1-c1cc(NCc2ncon2)c2n(nc(C)c2n1)C(C)C InChI=1S/C20H23N7O2/c1-5-28-20-14(7-6-8-21-20)15-9-16(22-10-17-23-11-29-26-17)19-18(24-15)13(4)25-27(19)12(2)3/h6-9,11-12H,5,10H2,1-4H3,(H,22,24) HUAHNRHWFFYRAT-UHFFFAOYSA-N 279023 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1,2,4-oxadiazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 53::US10512632, Example 53::US10766893, Example S53::US10806718, Example 53::US11026923, Example 53::US11491140, Example 53::US11634416, Example 53 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 9.30 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279023&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273357 378160612 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856143 CCOc1ncccc1-c1cc(NCc2cc(C)n(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H29N7O/c1-7-31-23-18(9-8-10-24-23)19-12-20(25-13-17-11-15(4)29(6)28-17)22-21(26-19)16(5)27-30(22)14(2)3/h8-12,14H,7,13H2,1-6H3,(H,25,26) LOSBPLVFUGTAOA-UHFFFAOYSA-N 279024 N-[(1,5-dimethylpyrazol-3-yl)methyl]-5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 54::US10512632, Example 54::US10806718, Example 54::US11026923, Example 54::US11491140, Example 54::US11634416, Example 54 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.390 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279024 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279024&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273352 378160613 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856146 CCOc1ncccc1-c1cc(NCc2n[nH]c(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-6-30-21-15(8-7-9-22-21)16-10-17(23-11-18-24-14(5)26-27-18)20-19(25-16)13(4)28-29(20)12(2)3/h7-10,12H,6,11H2,1-5H3,(H,23,25)(H,24,26,27) QVFBWQCMGPADBC-UHFFFAOYSA-N 279025 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methyl-1H-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 55::US10512632, Example 55::US10766893, Example S55::US10806718, Example 55::US11026923, Example 55::US11491140, Example 55::US11634416, Example 55 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 3.40 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279025&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273353 378160614 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856149 CCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(ncc2n1)C(C)C InChI=1S/C20H24N8O/c1-5-29-20-14(7-6-8-21-20)15-9-16(22-11-18-23-12-27(4)26-18)19-17(25-15)10-24-28(19)13(2)3/h6-10,12-13H,5,11H2,1-4H3,(H,22,25) LBAWYUCYPDZBSF-UHFFFAOYSA-N 279026 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 56::US10512632, Example 56::US10766893, Example S56::US10806718, Example 56::US11026923, Example 56::US11491140, Example 56::US11634416, Example 56 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 16.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279026&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273358 378160615 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856152 CCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(ncc2n1)C(C)C InChI=1S/C20H23N7O/c1-4-28-20-15(6-5-8-21-20)16-10-17(22-11-14-7-9-23-26-14)19-18(25-16)12-24-27(19)13(2)3/h5-10,12-13H,4,11H2,1-3H3,(H,22,25)(H,23,26) RZEYZCLEVMBHDS-UHFFFAOYSA-N 279027 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 57::US10512632, Example 57::US10766893, Example S57::US10806718, Example 57::US11026923, Example 57::US11491140, Example 57::US11634416, Example 57 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 98.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279027&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273355 378160616 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856155 CCOc1ncccc1-c1cc(NCc2cn(C)cn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H27N7O/c1-6-30-22-17(8-7-9-23-22)18-10-19(24-11-16-12-28(5)13-25-16)21-20(26-18)15(4)27-29(21)14(2)3/h7-10,12-14H,6,11H2,1-5H3,(H,24,26) LRTCNZDFQQIFPH-UHFFFAOYSA-N 279028 5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((1-methyl-1H-imidazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine 2,2,2-trifluoroacetate::US10034861, Example 58::US10512632, Example 58::US10766893, Example S58::US10806718, Example 58::US11026923, Example 58::US11491140, Example 58::US11634416, Example 58 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.10 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279028&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273360 378160617 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856158 CCOc1ncccc1-c1cc(NCc2nnco2)c2n(nc(C)c2n1)C(C)C InChI=1S/C20H23N7O2/c1-5-28-20-14(7-6-8-21-20)15-9-16(22-10-17-25-23-11-29-17)19-18(24-15)13(4)26-27(19)12(2)3/h6-9,11-12H,5,10H2,1-4H3,(H,22,24) AHFKEZBAZQXEDY-UHFFFAOYSA-N 279029 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1,3,4-oxadiazol-2-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 59::US10512632, Example 59::US10766893, Example S59::US10806718, Example 59::US11026923, Example 59::US11491140, Example 59::US11634416, Example 59 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 55.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279029&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273356 378160618 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856161 CCOc1ncccc1-c1cc(NCc2ccn(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H27N7O/c1-6-30-22-17(8-7-10-23-22)18-12-19(24-13-16-9-11-28(5)27-16)21-20(25-18)15(4)26-29(21)14(2)3/h7-12,14H,6,13H2,1-5H3,(H,24,25) FXMRNOZDEMMBMY-UHFFFAOYSA-N 279030 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(1-methylpyrazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 60::US10512632, Example 60::US10766893, Example S60::US10806718, Example 60::US11491140, Example 60::US11634416, Example 60 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 6.50 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279030&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273369 378160619 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856164 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1cn(C)nc1C InChI=1S/C20H26N8/c1-12(2)28-20-18(21-8-15-9-22-26(5)10-15)7-17(23-19(20)14(4)25-28)16-11-27(6)24-13(16)3/h7,9-12H,8H2,1-6H3,(H,21,23) SZOKENQFAYLAJE-UHFFFAOYSA-N 279031 5-(1,3-dimethylpyrazol-4-yl)-1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 61::US10512632, Example 61::US10618913, Example S61::US10766893, Example S61::US10806718, Example 61::US11491140, Example 61::US11634416, Example 61 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 550 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279031&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273370 378160620 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856167 COc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H25N7O/c1-13(2)28-20-18(23-10-15-11-24-27(4)12-15)9-17(25-19(20)14(3)26-28)16-7-6-8-22-21(16)29-5/h6-9,11-13H,10H2,1-5H3,(H,23,25) NDQZTZXQHDYXCS-UHFFFAOYSA-N 279032 1-isopropyl-5-(2-methoxy-3-pyridyl)-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 62::US10512632, Example 62::US10766893, Example S62::US10806718, Example 62::US11491140, Example 62::US11634416, Example 62 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 16.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279032&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273362 378160621 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856170 COc1ccccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6O/c1-14(2)28-22-19(23-11-16-12-24-27(4)13-16)10-18(25-21(22)15(3)26-28)17-8-6-7-9-20(17)29-5/h6-10,12-14H,11H2,1-5H3,(H,23,25) KTDTYSKLFCIVHF-UHFFFAOYSA-N 279033 1-isopropyl-5-(2-methoxyphenyl)-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 63::US10512632, Example 63::US10766893, Example S63::US10806718, Example 63::US11491140, Example 63::US11634416, Example 63 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 64.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279033&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273359 378160622 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856173 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1ccccc1 InChI=1S/C21H24N6/c1-14(2)27-21-19(22-11-16-12-23-26(4)13-16)10-18(17-8-6-5-7-9-17)24-20(21)15(3)25-27/h5-10,12-14H,11H2,1-4H3,(H,22,24) JFQFIBIPASGZMG-UHFFFAOYSA-N 279034 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-phenyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 64::US10512632, Example 64::US10766893, Example S64::US10806718, Example 64::US11491140, Example 64::US11634416, Example 64 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 52.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279034&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273365 378160623 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856176 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1ccsc1C InChI=1S/C20H24N6S/c1-12(2)26-20-18(21-9-15-10-22-25(5)11-15)8-17(16-6-7-27-14(16)4)23-19(20)13(3)24-26/h6-8,10-12H,9H2,1-5H3,(H,21,23) OOGMCENLMFETDO-UHFFFAOYSA-N 279035 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-(2-methyl-3-thienyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 65::US10512632, Example 65::US10766893, Example S65::US10806718, Example 65::US11491140, Example 65::US11634416, Example 65 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 7.90 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279035&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273363 378160624 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856179 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1cnn(C)c1C InChI=1S/C20H26N8/c1-12(2)28-20-18(21-8-15-9-22-26(5)11-15)7-17(24-19(20)13(3)25-28)16-10-23-27(6)14(16)4/h7,9-12H,8H2,1-6H3,(H,21,24) IOBLPVSVJNVETM-UHFFFAOYSA-N 279036 5-(1,5-dimethylpyrazol-4-yl)-1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 66::US10512632, Example 66::US10766893, Example S66::US10806718, Example 66::US11491140, Example 66::US11634416, Example 66 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 210 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279036&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273361 378160625 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856182 CCOc1ncccc1-c1cc(NCc2ccn(C)n2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C23H29N7O/c1-6-15(3)30-22-20(25-14-17-10-12-29(5)28-17)13-19(26-21(22)16(4)27-30)18-9-8-11-24-23(18)31-7-2/h8-13,15H,6-7,14H2,1-5H3,(H,25,26) GUZUXYPWYDLGJF-UHFFFAOYSA-N 279037 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]-N-[(1-methylpyrazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 67::US10512632, Example 67::US10618913, Example S67::US10766893, Example S67::US10806718, Example 67::US11634416, Example 67 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 9.60 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279037 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279037&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273371 378160626 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856185 CCCOc1ncccc1-c1cc(NCc2nnn(C)n2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C22H29N9O/c1-6-11-32-22-16(9-8-10-23-22)17-12-18(24-13-19-26-29-30(5)28-19)21-20(25-17)15(4)27-31(21)14(3)7-2/h8-10,12,14H,6-7,11,13H2,1-5H3,(H,24,25) DGDYHVXCROBNNK-UHFFFAOYSA-N 279038 3-methyl-1-[1-methylpropyl]-N-[(2-methyltetrazol-5-yl)methyl]-5-(2-propoxy-3-pyridyl)pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 68::US10512632, Example 68::US10766893, Example S68::US10806718, Example 68::US11634416, Example 68 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.790 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279038 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279038&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273364 378160627 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856188 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(ncc2n1)C(C)CC InChI=1S/C22H27N7O/c1-5-15(3)29-21-19(24-11-16-12-25-28(4)14-16)10-18(27-20(21)13-26-29)17-8-7-9-23-22(17)30-6-2/h7-10,12-15H,5-6,11H2,1-4H3,(H,24,27) PNGBBNJWUZFNIY-UHFFFAOYSA-N 279039 5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine, enantiomer 1::US10034861, Example 69::US10034861, Example 70::US10512632, Example 70::US10618913, Example S69::US10766893, Example S70::US10806718, Example 70::US11634416, Example 70 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 14.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279039&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273366 378160628 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856191 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(ncc2n1)C(C)CC InChI=1S/C22H27N7O/c1-5-15(3)29-21-19(24-11-16-12-25-28(4)14-16)10-18(27-20(21)13-26-29)17-8-7-9-23-22(17)30-6-2/h7-10,12-15H,5-6,11H2,1-4H3,(H,24,27) PNGBBNJWUZFNIY-UHFFFAOYSA-N 279039 5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine, enantiomer 1::US10034861, Example 69::US10034861, Example 70::US10512632, Example 70::US10618913, Example S69::US10766893, Example S70::US10806718, Example 70::US11634416, Example 70 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 140 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279039&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273366 378160628 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856194 CCOc1ncccc1-c1cc(NCc2scnc2C)c2n(ncc2n1)C(C)C InChI=1S/C21H24N6OS/c1-5-28-21-15(7-6-8-22-21)16-9-17(23-11-19-14(4)24-12-29-19)20-18(26-16)10-25-27(20)13(2)3/h6-10,12-13H,5,11H2,1-4H3,(H,23,26) CKGZFAMXPLRINR-UHFFFAOYSA-N 424981 US10512632, Example 71::US10766893, Example S71::US10806718, Example 71::US11026923, Example 71::US11491140, Example 71::US11634416, Example 71 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 170 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=424981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=424981&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138536011 434150492 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856197 CCOc1ncccc1-c1cc(OCc2cnc(C)o2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H25N5O3/c1-6-28-22-17(8-7-9-23-22)18-10-19(29-12-16-11-24-15(5)30-16)21-20(25-18)14(4)26-27(21)13(2)3/h7-11,13H,6,12H2,1-5H3 PFDYAXRVKURLCH-UHFFFAOYSA-N 279042 5-[[5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-yl]oxymethyl]-2-methyl-oxazole::US10034861, Example 72::US10512632, Example 72::US10766893, Example S72::US10806718, Example 72::US11491140, Example 72::US11634416, Example 72 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 14.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279042&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273372 378160630 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856200 CCOc1ncccc1-c1cc(NCc2ccncn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H25N7O/c1-5-30-22-17(7-6-9-24-22)18-11-19(25-12-16-8-10-23-13-26-16)21-20(27-18)15(4)28-29(21)14(2)3/h6-11,13-14H,5,12H2,1-4H3,(H,25,27) UIVWJGFOIVSSOG-UHFFFAOYSA-N 279043 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(pyrimidin-4-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 73::US10512632, Example 73::US10766893, Example S73::US10806718, Example 73::US11491140, Example 73::US11634416, Example 73 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 81.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279043&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273379 378160631 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856203 CCOc1ncccc1-c1cc(NCc2ncccn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H25N7O/c1-5-30-22-16(8-6-9-25-22)17-12-18(26-13-19-23-10-7-11-24-19)21-20(27-17)15(4)28-29(21)14(2)3/h6-12,14H,5,13H2,1-4H3,(H,26,27) DFFZMDINLLNNPV-UHFFFAOYSA-N 279044 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(pyrimidin-2-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 74::US10512632, Example 74::US10766893, Example S74::US10806718, Example 74::US11491140, Example 74::US11634416, Example 74 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.10 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279044&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273368 378160632 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856206 CCOc1ncccc1-c1cc(NCc2nccc(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O/c1-6-31-23-17(8-7-10-25-23)18-12-19(26-13-20-24-11-9-15(4)27-20)22-21(28-18)16(5)29-30(22)14(2)3/h7-12,14H,6,13H2,1-5H3,(H,26,28) ZCARSOPJYGJCRQ-UHFFFAOYSA-N 279045 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(4-methylpyrimidin-2-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 75::US10512632, Example 75::US10806718, Example 75::US11026923, Example 75::US11491140, Example 75::US11634416, Example 75 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 9.90 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279045&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273374 378160633 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856209 CCOc1ncccc1-c1cc(NCc2cnccn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H25N7O/c1-5-30-22-17(7-6-8-25-22)18-11-19(26-13-16-12-23-9-10-24-16)21-20(27-18)15(4)28-29(21)14(2)3/h6-12,14H,5,13H2,1-4H3,(H,26,27) DTEHKURDWHCADV-UHFFFAOYSA-N 279046 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(pyrazin-2-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 76::US10512632, Example 76::US10766893, Example S76::US10806718, Example 76::US11026923, Example 76::US11491140, Example 76::US11634416, Example 76 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 23.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279046&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273373 378160634 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856212 CCOc1ncccc1-c1cc(NCc2cccnc2C(F)(F)F)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H25F3N6O/c1-5-34-23-17(9-7-11-29-23)18-12-19(21-20(31-18)15(4)32-33(21)14(2)3)30-13-16-8-6-10-28-22(16)24(25,26)27/h6-12,14H,5,13H2,1-4H3,(H,30,31) TZBBGNNWRKPAEH-UHFFFAOYSA-N 279047 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[2-(trifluoromethyl)-3-pyridyl]methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 77::US10512632, Example 77::US10766893, Example S77::US10806718, Example 77::US11026923, Example 77::US11491140, Example 77::US11634416, Example 77 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 21.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279047&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273376 378160635 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856215 CCOc1ncccc1-c1cc(NCc2ccn(C)c(=O)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(8-7-10-25-24)19-13-20(26-14-17-9-11-29(5)21(31)12-17)23-22(27-19)16(4)28-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,26,27) IBAWDCALOOJODQ-UHFFFAOYSA-N 279048 4-[[[5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-yl]amino]methyl]-1-methyl-pyridin-2-one::US10034861, Example 78::US10512632, Example 78::US10766893, Example S78::US10806718, Example 78::US11026923, Example 78::US11491140, Example 78::US11634416, Example 78 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 27.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279048&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273377 378160636 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856218 CCNc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H28N8/c1-6-23-22-17(8-7-9-24-22)18-10-19(25-11-16-12-26-29(5)13-16)21-20(27-18)15(4)28-30(21)14(2)3/h7-10,12-14H,6,11H2,1-5H3,(H,23,24)(H,25,27) ZEUKRJZWWLBXIK-UHFFFAOYSA-N 279049 5-(2-(ethylamino)pyridin-3-yl)-1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 79::US10512632, Example 79::US10766893, Example S79::US10806718, Example 79::US11026923, Example 79::US11491140, Example 79::US11634416, Example 79 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 230 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279049&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273375 378160637 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856221 CCOc1ncccc1-c1cc(NCc2cc(OC)ccn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-19(8-7-10-26-24)20-13-21(27-14-17-12-18(31-5)9-11-25-17)23-22(28-20)16(4)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) BVKDBZHCRMPMSA-UHFFFAOYSA-N 279050 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(4-methoxy-2-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 81::US10512632, Example 81::US10766893, Example S81::US10806718, Example 81::US11026923, Example 81::US11491140, Example 81::US11634416, Example 81 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.000 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279050&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273378 378160638 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856224 CCOc1ncccc1-c1cc(NCc2cncc(OC)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O2/c1-6-32-23-17(8-7-9-25-23)18-10-19(26-12-16-11-24-13-20(27-16)31-5)22-21(28-18)15(4)29-30(22)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,26,28) OSHMEGNKNUJDSU-UHFFFAOYSA-N 279051 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(6-methoxypyrazin-2-yl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 82::US10512632, Example 82::US10766893, Example S82::US10806718, Example 82::US11026923, Example 82::US11491140, Example 82::US11634416, Example 82 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 16.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279051&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273380 378160639 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856227 CCOc1ncccc1-c1cc(NCc2ncc(F)cn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H24FN7O/c1-5-31-22-16(7-6-8-24-22)17-9-18(25-12-19-26-10-15(23)11-27-19)21-20(28-17)14(4)29-30(21)13(2)3/h6-11,13H,5,12H2,1-4H3,(H,25,28) ZIOQYWFVMVDZRK-UHFFFAOYSA-N 279052 5-(2-ethoxy-3-pyridyl)-N-[(5-fluoropyrimidin-2-yl)methyl]-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 83::US10512632, Example 83::US10766893, Example S83::US10806718, Example 83::US11026923, Example 83::US11491140, Example 83::US11634416, Example 83 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 17.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279052&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273381 378160640 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856230 CCOc1ncccc1-c1cc(NCc2cccnc2C)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O/c1-6-31-24-19(10-8-12-26-24)20-13-21(27-14-18-9-7-11-25-16(18)4)23-22(28-20)17(5)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) JOFWPJKNNJOGJF-UHFFFAOYSA-N 279053 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methyl-3-pyridyl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 84::US10512632, Example 84::US10766893, Example S84::US10806718, Example 84::US11026923, Example 84::US11491140, Example 84::US11634416, Example 84 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 19.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279053&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273382 378160641 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856233 CCOc1ncccc1-c1cc(NCc2cccnc2F)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H25FN6O/c1-5-31-23-17(9-7-11-26-23)18-12-19(27-13-16-8-6-10-25-22(16)24)21-20(28-18)15(4)29-30(21)14(2)3/h6-12,14H,5,13H2,1-4H3,(H,27,28) JJLMBZVLDAMDGO-UHFFFAOYSA-N 279054 5-(2-ethoxy-3-pyridyl)-N-[(2-fluoro-3-pyridyl)methyl]-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 85::US10512632, Example 85::US10766893, Example S85::US10806718, Example 85::US11026923, Example 85::US11491140, Example 85::US11634416, Example 85 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.40 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279054&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273384 378160642 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856236 CCOc1ncccc1-c1cc(NCc2cccnc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(10-8-12-26-24)19-13-20(27-14-17-9-7-11-25-23(17)31-5)22-21(28-19)16(4)29-30(22)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) LOZUTDKVJLMDTB-UHFFFAOYSA-N 279055 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 172::US10034861, Example 180::US10034861, Example 181::US10034861, Example 182::US10034861, Example 86::US10512632, Example 86::US10766893, Example S86::US10806718, Example 182::US11026923, Example 182::US11491140, Example 86::US11634416, Example 86 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 20.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279055&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273386 378160643 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856239 CCOc1ncccc1-c1cc(NCc2ccc(C)nc2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O/c1-6-31-24-19(8-7-11-25-24)20-12-21(27-14-18-10-9-16(4)26-13-18)23-22(28-20)17(5)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) VEZPCNBBBMUATR-UHFFFAOYSA-N 279056 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(6-methyl-3-pyridyl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 87::US10512632, Example 87::US10766893, Example S87::US10806718, Example 87::US11026923, Example 87::US11491140, Example 87::US11634416, Example 87 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 6.30 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279056 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279056&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273383 378160644 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856242 CCOc1ncccc1-c1cc(NCc2ccccc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C25H29N5O2/c1-6-32-25-19(11-9-13-26-25)20-14-21(27-15-18-10-7-8-12-22(18)31-5)24-23(28-20)17(4)29-30(24)16(2)3/h7-14,16H,6,15H2,1-5H3,(H,27,28) IXQRCVAKBIMUJN-UHFFFAOYSA-N 279057 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxyphenyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 88::US10512632, Example 88::US10766893, Example S88::US10806718, Example 88::US11026923, Example 88::US11491140, Example 88::US11634416, Example 88 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 110 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279057&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273385 378160645 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856245 CCOc1ncccc1-c1cc(NCc2ccccc2F)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H26FN5O/c1-5-31-24-18(10-8-12-26-24)20-13-21(27-14-17-9-6-7-11-19(17)25)23-22(28-20)16(4)29-30(23)15(2)3/h6-13,15H,5,14H2,1-4H3,(H,27,28) PBVAXRZBSWSQNU-UHFFFAOYSA-N 279058 5-(2-ethoxy-3-pyridyl)-N-[(2-fluorophenyl)methyl]-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 89::US10512632, Example 89::US10766893, Example S89::US10806718, Example 89::US11026923, Example 89::US11491140, Example 89::US11634416, Example 89 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 61.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279058&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273388 378160646 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856248 CCOc1ncccc1-c1cc(NCc2ccccc2C(F)(F)F)c2n(nc(C)c2n1)C(C)C InChI=1S/C25H26F3N5O/c1-5-34-24-18(10-8-12-29-24)20-13-21(23-22(31-20)16(4)32-33(23)15(2)3)30-14-17-9-6-7-11-19(17)25(26,27)28/h6-13,15H,5,14H2,1-4H3,(H,30,31) XUHWSBHEGYQEDI-UHFFFAOYSA-N 279059 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[2-(trifluoromethyl)phenyl]methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 90::US10512632, Example 90::US10766893, Example S90::US10806718, Example 90::US11026923, Example 90::US11491140, Example 90::US11634416, Example 90 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 270 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279059&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273387 378160647 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856251 CCOc1ncccc1-c1cc(NCc2nccnc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O2/c1-6-32-22-16(8-7-9-25-22)17-12-18(27-13-19-23(31-5)26-11-10-24-19)21-20(28-17)15(4)29-30(21)14(2)3/h7-12,14H,6,13H2,1-5H3,(H,27,28) GJZNHSHBNVLOAO-UHFFFAOYSA-N 279060 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(3-methoxypyrazin-2-yl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 91::US10512632, Example 91::US10766893, Example S91::US10806718, Example 91::US11026923, Example 91::US11491140, Example 91::US11634416, Example 91 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 27.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279060&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273389 378160648 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856254 CCOc1ncccc1-c1cc(NCc2cnccc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(8-7-10-26-24)19-12-20(27-14-17-13-25-11-9-21(17)31-5)23-22(28-19)16(4)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) BHINMZMKXRIBEG-UHFFFAOYSA-N 279061 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(4-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 92::US10512632, Example 92::US10766893, Example S92::US10806718, Example 92::US11026923, Example 92::US11491140, Example 92::US11634416, Example 92 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 47.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279061&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273390 378160649 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856257 CCCOc1ncccc1-c1cc(NCc2nnn(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H27N9O/c1-6-10-31-21-15(8-7-9-22-21)16-11-17(23-12-18-25-28-29(5)27-18)20-19(24-16)14(4)26-30(20)13(2)3/h7-9,11,13H,6,10,12H2,1-5H3,(H,23,24) IEZRRRCALKIRBN-UHFFFAOYSA-N 279062 1-isopropyl-3-methyl-N-[(2-methyltetrazol-5-yl)methyl]-5-(2-propoxy-3-pyridyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 93::US10512632, Example 93::US10766893, Example S93::US10806718, Example 93::US11026923, Example 93::US11491140, Example 93::US11634416, Example 93 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4.30 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279062&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273393 378160650 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856260 CCCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H29N7O/c1-6-10-31-23-18(8-7-9-24-23)19-11-20(25-12-17-13-26-29(5)14-17)22-21(27-19)16(4)28-30(22)15(2)3/h7-9,11,13-15H,6,10,12H2,1-5H3,(H,25,27) JYRPZCKZXZYAOY-UHFFFAOYSA-N 279063 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-(2-propoxy-3-pyridyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 94::US10512632, Example 94::US10766893, Example S94::US10806718, Example 94::US11026923, Example 94::US11491140, Example 94::US11634416, Example 94 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.40 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279063&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273391 378160651 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856566 CCCOc1ncccc1-c1cc(NCc2cn[nH]c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H27N7O/c1-5-9-30-22-17(7-6-8-23-22)18-10-19(24-11-16-12-25-26-13-16)21-20(27-18)15(4)28-29(21)14(2)3/h6-8,10,12-14H,5,9,11H2,1-4H3,(H,24,27)(H,25,26) FTOYLOIRXWDMMT-UHFFFAOYSA-N 279165 1-isopropyl-3-methyl-5-(2-propoxy-3-pyridyl)-N-(1H-pyrazol-4-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 196::US10512632, Example 196::US11491140, Example 196::US11634416, Example 196 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 18.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279165&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273488 378160742 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856569 CCOc1ncccc1-c1cc(NCc2cccnc2OC)c2n(nc(C)c2n1)C1COC1 InChI=1S/C24H26N6O3/c1-4-33-24-18(8-6-10-26-24)19-11-20(27-12-16-7-5-9-25-23(16)31-3)22-21(28-19)15(2)29-30(22)17-13-32-14-17/h5-11,17H,4,12-14H2,1-3H3,(H,27,28) GRFJYHDUOKDAKO-UHFFFAOYSA-N 279166 5-(2-ethoxy-3-pyridyl)-N-[(2-methoxy-3-pyridyl)methyl]-3-methyl-1-(oxetan-3-yl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 197::US10512632, Example 197::US10618913, Example S197::US10766893, Example S197::US10806718, Example 197::US11491140, Example 197::US11634416, Example 197 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 190 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279166&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273484 378160743 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856572 CCN(C)c1ncccc1-c1cc(NCc2ccc(OC)cc2)c2n(nc(C)c2n1)C(C)C InChI=1S/C26H32N6O/c1-7-31(5)26-21(9-8-14-27-26)22-15-23(28-16-19-10-12-20(33-6)13-11-19)25-24(29-22)18(4)30-32(25)17(2)3/h8-15,17H,7,16H2,1-6H3,(H,28,29) YNHQWVLFISTQIU-UHFFFAOYSA-N 279167 5-(2-(ethyl(methyl)amino)pyridin-3-yl)-1-isopropyl-N-(4-methoxybenzyl)-3-methyl-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 198::US10512632, Example 198::US10766893, Example S198::US10806718, Example 198::US11026923, Example 198::US11491140, Example 198::US11634416, Example 198 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1100 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279167 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279167&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273483 378160744 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856575 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(CF)c2n1)C(C)C InChI=1S/C22H26FN7O/c1-5-31-22-16(7-6-8-24-22)17-9-18(25-11-15-12-26-29(4)13-15)21-20(27-17)19(10-23)28-30(21)14(2)3/h6-9,12-14H,5,10-11H2,1-4H3,(H,25,27) CRFWOMGBISLKHY-UHFFFAOYSA-N 279168 5-(2-ethoxypyridin-3-yl)-3-(fluoromethyl)-1-isopropyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 199::US10512632, Example 199::US10618913, Example S199::US10766893, Example S199::US10806718, Example 199::US11026923, Example 199::US11491140, Example 199::US11634416, Example 199 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 7.40 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279168&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273487 378160745 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856578 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1ocnc1C InChI=1S/C19H23N7O/c1-11(2)26-18-15(20-7-14-8-22-25(5)9-14)6-16(19-13(4)21-10-27-19)23-17(18)12(3)24-26/h6,8-11H,7H2,1-5H3,(H,20,23) JVGYDVFOXCBHRN-UHFFFAOYSA-N 279169 1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-5-(4-methyloxazol-5-yl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 200::US10512632, Example 200::US10618913, Example S200::US10766893, Example S200::US10806718, Example 200::US11026923, Example 200::US11491140, Example 200::US11634416, Example 200 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 98.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279169&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273489 378160746 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856581 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1cccnc1N(C)C InChI=1S/C22H28N8/c1-14(2)30-21-19(24-11-16-12-25-29(6)13-16)10-18(26-20(21)15(3)27-30)17-8-7-9-23-22(17)28(4)5/h7-10,12-14H,11H2,1-6H3,(H,24,26) JWSSTJTVRAZILB-UHFFFAOYSA-N 279170 5-[2-(dimethylamino)-3-pyridyl]-1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 201::US10512632, Example 201::US10766893, Example S201::US10806718, Example 201::US11026923, Example 201::US11491140, Example 201::US11634416, Example 201 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2100 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279170&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273490 378160747 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856584 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1nc(C)co1 InChI=1S/C19H23N7O/c1-11(2)26-18-15(20-7-14-8-21-25(5)9-14)6-16(19-22-12(3)10-27-19)23-17(18)13(4)24-26/h6,8-11H,7H2,1-5H3,(H,20,23) GNUZZRWHGHQDMA-UHFFFAOYSA-N 279171 1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-5-(4-methyloxazol-2-yl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 202::US10512632, Example 202::US10766893, Example S202::US10806718, Example 202::US11634416, Example 202 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 92.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279171&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273491 378160748 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856587 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1nncn1C InChI=1S/C18H23N9/c1-11(2)27-17-14(19-7-13-8-21-26(5)9-13)6-15(18-23-20-10-25(18)4)22-16(17)12(3)24-27/h6,8-11H,7H2,1-5H3,(H,19,22) KAIFDCSXZCWWKF-UHFFFAOYSA-N 279172 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-(4-methyl-1,2,4-triazol-3-::US10034861, Example 203::US10512632, Example 203::US10766893, Example S203::US10806718, Example 203::US11026923, Example 203::US11491140, Example 203::US11634416, Example 203 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 410 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279172 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279172&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273492 378160749 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856263 COc1ncccc1CNc1cc(nc2c(C)nn(C(C)C)c12)-c1cccnc1OC InChI=1S/C23H26N6O2/c1-14(2)29-21-19(26-13-16-8-6-10-24-22(16)30-4)12-18(27-20(21)15(3)28-29)17-9-7-11-25-23(17)31-5/h6-12,14H,13H2,1-5H3,(H,26,27) YPNDBZHHIYJRNN-UHFFFAOYSA-N 279064 1-isopropyl-5-(2-methoxy-3-pyridyl)-N-[(2-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 95::US10512632, Example 95::US10766893, Example S95::US10806718, Example 95::US11026923, Example 95::US11491140, Example 95::US11634416, Example 95 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 42.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279064 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279064&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273392 378160652 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856266 COc1ccc(CNc2cc(nc3c(C)nn(C(C)C)c23)-c2cccnc2OC)cn1 InChI=1S/C23H26N6O2/c1-14(2)29-22-19(25-12-16-8-9-20(30-4)26-13-16)11-18(27-21(22)15(3)28-29)17-7-6-10-24-23(17)31-5/h6-11,13-14H,12H2,1-5H3,(H,25,27) HUQJJAUBVULGLS-UHFFFAOYSA-N 279065 1-isopropyl-5-(2-methoxy-3-pyridyl)-N-[(6-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 96::US10512632, Example 96::US10766893, Example S96::US10806718, Example 96::US11026923, Example 96::US11491140, Example 96::US11634416, Example 96 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 18.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279065&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273394 378160653 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856269 CC(C)Oc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H29N7O/c1-14(2)30-22-20(25-11-17-12-26-29(6)13-17)10-19(27-21(22)16(5)28-30)18-8-7-9-24-23(18)31-15(3)4/h7-10,12-15H,11H2,1-6H3,(H,25,27) IWDHUHWZRSHWGD-UHFFFAOYSA-N 279066 5-(2-isopropoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 97::US10512632, Example 97::US10766893, Example S97::US10806718, Example 97::US11026923, Example 97::US11491140, Example 97::US11634416, Example 97 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.40 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279066&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273395 378160654 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856272 CCOc1ncccc1-c1cc(NCc2nc[nH]n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C20H24N8O/c1-5-29-20-14(7-6-8-21-20)15-9-16(22-10-17-23-11-24-26-17)19-18(25-15)13(4)27-28(19)12(2)3/h6-9,11-12H,5,10H2,1-4H3,(H,22,25)(H,23,24,26) ZUZXEJWHRNAFBA-UHFFFAOYSA-N 279067 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1H-1,2,4-triazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 98::US10512632, Example 98::US10766893, Example S98::US10806718, Example 98::US11491140, Example 98::US11634416, Example 98 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 7.20 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279067 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279067&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273396 378160655 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856275 CCOc1ncccc1-c1cc(NCc2nn[nH]n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C19H23N9O/c1-5-29-19-13(7-6-8-20-19)14-9-15(21-10-16-23-26-27-24-16)18-17(22-14)12(4)25-28(18)11(2)3/h6-9,11H,5,10H2,1-4H3,(H,21,22)(H,23,24,26,27) DBRGOFPEANLZGU-UHFFFAOYSA-N 279068 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(2H-tetrazol-5-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 99::US10512632, Example 99::US10766893, Example S99::US10806718, Example 99::US11026923, Example 99::US11491140, Example 99::US11634416, Example 99 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.730 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279068&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273399 378160656 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856278 CCOc1ncccc1-c1cc(NCc2ccccn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H26N6O/c1-5-30-23-18(10-8-12-25-23)19-13-20(26-14-17-9-6-7-11-24-17)22-21(27-19)16(4)28-29(22)15(2)3/h6-13,15H,5,14H2,1-4H3,(H,26,27) GWMDZOSIIBARTA-UHFFFAOYSA-N 279069 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(2-pyridylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 100::US10512632, Example 100::US10766893, Example S100::US10806718, Example 100::US11026923, Example 100::US11491140, Example 100::US11634416, Example 100 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 6.30 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279069&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273397 378160657 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856281 CCOc1ncccc1-c1cc(NCc2cccc(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O/c1-6-31-24-19(11-8-12-25-24)20-13-21(26-14-18-10-7-9-16(4)27-18)23-22(28-20)17(5)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,26,28) HBRGVUVPCCNRAT-UHFFFAOYSA-N 279070 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(6-methyl-2-pyridyl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 101::US10512632, Example 101::US10766893, Example S101::US10806718, Example 101::US11026923, Example 101::US11491140, Example 101::US11634416, Example 101 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 20.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279070&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273398 378160658 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856284 CCOc1ncccc1-c1cc(NCc2cccc(OC)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(10-8-12-25-24)19-13-20(26-14-17-9-7-11-21(27-17)31-5)23-22(28-19)16(4)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,26,28) DHUHVCYRBUZRAT-UHFFFAOYSA-N 279071 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(6-methoxy-2-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 102::US10512632, Example 102::US10766893, Example S102::US10806718, Example 102::US11026923, Example 102::US11491140, Example 102::US11634416, Example 102 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.00 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279071&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273400 378160659 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856287 CCOc1ncccc1-c1cc(NCc2ccnc(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O/c1-6-31-24-19(8-7-10-26-24)20-13-21(27-14-18-9-11-25-16(4)12-18)23-22(28-20)17(5)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) MPJXQIBFZBPJFH-UHFFFAOYSA-N 279072 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methyl-4-pyridyl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 103::US10512632, Example 103::US10766893, Example S103::US10806718, Example 103::US11026923, Example 103::US11491140, Example 103::US11634416, Example 103 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 5.40 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279072&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273402 378160660 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856290 CCOc1ncccc1-c1cc(NCc2ccnc(OC)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(8-7-10-26-24)19-13-20(27-14-17-9-11-25-21(12-17)31-5)23-22(28-19)16(4)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) SJJQCULDRYOYED-UHFFFAOYSA-N 279073 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-4-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 104::US10512632, Example 104::US10766893, Example S104::US10806718, Example 104::US11026923, Example 104::US11491140, Example 104::US11634416, Example 104 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.20 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279073&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273401 378160661 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856293 CCOc1ncccc1-c1cc(NCc2ccnc(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O/c1-6-31-23-18(8-7-10-25-23)19-12-20(26-13-17-9-11-24-16(5)27-17)22-21(28-19)15(4)29-30(22)14(2)3/h7-12,14H,6,13H2,1-5H3,(H,26,28) OEGPBHHKEYGZCG-UHFFFAOYSA-N 279074 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methylpyrimidin-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 105::US10512632, Example 105::US10766893, Example S105::US10806718, Example 105::US11026923, Example 105::US11491140, Example 105::US11634416, Example 105 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 54.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279074&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273403 378160662 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856296 CCOc1ncccc1-c1cc(NCc2cncc(OC)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-19(8-7-9-26-24)20-11-21(27-13-17-10-18(31-5)14-25-12-17)23-22(28-20)16(4)29-30(23)15(2)3/h7-12,14-15H,6,13H2,1-5H3,(H,27,28) JCOKQWFPIMEUNS-UHFFFAOYSA-N 279075 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(5-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 106::US10512632, Example 106::US10766893, Example S106::US10806718, Example 106::US11026923, Example 106::US11491140, Example 106::US11634416, Example 106 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.10 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279075&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273404 378160663 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856299 CCOc1ncccc1-c1cc(NCc2cccc(n2)C(F)(F)F)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H25F3N6O/c1-5-34-23-17(9-7-11-28-23)18-12-19(22-21(31-18)15(4)32-33(22)14(2)3)29-13-16-8-6-10-20(30-16)24(25,26)27/h6-12,14H,5,13H2,1-4H3,(H,29,31) FVVVRFIRYVUVEI-UHFFFAOYSA-N 279076 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[6-(trifluoromethyl)-2-pyridyl]methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 107::US10512632, Example 107::US10766893, Example S107::US10806718, Example 107::US11026923, Example 107::US11491140, Example 107::US11634416, Example 107 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 110 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279076&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273405 378160664 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856302 CCOc1ncccc1-c1cc(NCc2cccn(C)c2=O)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-23-18(10-7-11-25-23)19-13-20(26-14-17-9-8-12-29(5)24(17)31)22-21(27-19)16(4)28-30(22)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,26,27) YLQLMBPUXKUVLD-UHFFFAOYSA-N 279077 3-[[[5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-yl]amino]methyl]-1-methyl-pyridin-2-one::US10034861, Example 108::US10512632, Example 108::US10766893, Example S108::US10806718, Example 108::US11026923, Example 108::US11491140, Example 108::US11634416, Example 108 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.80 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279077&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273406 378160665 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856305 CCOc1ncccc1-c1cc(NCc2cnn(CC)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H29N7O/c1-6-29-14-17(13-26-29)12-25-20-11-19(18-9-8-10-24-23(18)31-7-2)27-21-16(5)28-30(15(3)4)22(20)21/h8-11,13-15H,6-7,12H2,1-5H3,(H,25,27) IEORIQPBXNSJCP-UHFFFAOYSA-N 279078 5-(2-ethoxy-3-pyridyl)-N-[(1-ethylpyrazol-4-yl)methyl]-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 109::US10512632, Example 109::US10766893, Example S109::US10806718, Example 109::US11026923, Example 109::US11491140, Example 109::US11634416, Example 109 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4.90 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279078&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273407 378160666 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856308 CCCn1cc(CNc2cc(nc3c(C)nn(C(C)C)c23)-c2cccnc2OCC)cn1 InChI=1S/C24H31N7O/c1-6-11-30-15-18(14-27-30)13-26-21-12-20(19-9-8-10-25-24(19)32-7-2)28-22-17(5)29-31(16(3)4)23(21)22/h8-10,12,14-16H,6-7,11,13H2,1-5H3,(H,26,28) NPLKFZSTTQLUHS-UHFFFAOYSA-N 279079 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(1-propylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 110::US10512632, Example 110::US10766893, Example S110::US10806718, Example 110::US11026923, Example 110::US11491140, Example 110::US11634416, Example 110 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 11.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279079&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273408 378160667 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856311 CCOc1ncccc1-c1cc(NCc2ccc(OC)nc2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(8-7-11-25-24)19-12-20(26-13-17-9-10-21(31-5)27-14-17)23-22(28-19)16(4)29-30(23)15(2)3/h7-12,14-15H,6,13H2,1-5H3,(H,26,28) XMJAAWKICASNAA-UHFFFAOYSA-N 279080 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(6-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 111::US10512632, Example 111::US10766893, Example S111::US10806718, Example 111::US11026923, Example 111::US11491140, Example 111::US11634416, Example 111 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 28.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279080 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279080&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273409 378160668 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856314 CCOc1ncccc1-c1cc(NCc2ccc(OC)cn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-19(8-7-11-25-24)20-12-21(27-13-17-9-10-18(31-5)14-26-17)23-22(28-20)16(4)29-30(23)15(2)3/h7-12,14-15H,6,13H2,1-5H3,(H,27,28) HWSJSACIWPNYOB-UHFFFAOYSA-N 279081 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(5-methoxy-2-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 112::US10512632, Example 112::US10766893, Example S112::US10806718, Example 112::US11026923, Example 112::US11491140, Example 112::US11634416, Example 112 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 61.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279081&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273411 378160669 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856317 CCOc1ncccc1-c1cc(NCc2csc(C)n2)c2n(nc(C)c2n1)C1COC1 InChI=1S/C22H24N6O2S/c1-4-30-22-17(6-5-7-23-22)18-8-19(24-9-15-12-31-14(3)25-15)21-20(26-18)13(2)27-28(21)16-10-29-11-16/h5-8,12,16H,4,9-11H2,1-3H3,(H,24,26) BSSGJYYHYVLYMA-UHFFFAOYSA-N 279082 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(2-methylthiazol-4-yl)methyl]-1-(oxetan-3-yl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 113::US10512632, Example 113::US10618913, Example S113::US10766893, Example S113::US10806718, Example 113::US11026923, Example 113::US11491140, Example 113::US11634416, Example 113 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 110 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279082&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273410 378160670 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856320 CCOc1ncccc1-c1cc(NCc2cnc(OC)cn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O2/c1-6-32-23-17(8-7-9-24-23)18-10-19(26-11-16-12-27-20(31-5)13-25-16)22-21(28-18)15(4)29-30(22)14(2)3/h7-10,12-14H,6,11H2,1-5H3,(H,26,28) QIWVSVNHRDQBOW-UHFFFAOYSA-N 279083 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(5-methoxypyrazin-2-yl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 114::US10512632, Example 114::US10766893, Example S114::US10806718, Example 114::US11026923, Example 114::US11491140, Example 114::US11634416, Example 114 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 24.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279083 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279083&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273413 378160671 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856323 CCOc1ncccc1-c1cc(NCc2cccnc2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H26N6O/c1-5-30-23-18(9-7-11-25-23)19-12-20(26-14-17-8-6-10-24-13-17)22-21(27-19)16(4)28-29(22)15(2)3/h6-13,15H,5,14H2,1-4H3,(H,26,27) MYYHBCJMEYIHMC-UHFFFAOYSA-N 279084 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(3-pyridylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 115::US10512632, Example 115::US10766893, Example S115::US10806718, Example 115::US11026923, Example 115::US11491140, Example 115::US11634416, Example 115 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 15.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279084&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273412 378160672 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856326 CCOc1ncccc1-c1cc(NCc2ccc(F)nc2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H25FN6O/c1-5-31-23-17(7-6-10-25-23)18-11-19(26-12-16-8-9-20(24)27-13-16)22-21(28-18)15(4)29-30(22)14(2)3/h6-11,13-14H,5,12H2,1-4H3,(H,26,28) SKXWAYULKGVUDE-UHFFFAOYSA-N 279085 5-(2-ethoxy-3-pyridyl)-N-[(6-fluoro-3-pyridyl)methyl]-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 116::US10512632, Example 116::US10766893, Example S116::US10806718, Example 116::US11026923, Example 116::US11491140, Example 116::US11634416, Example 116 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 21.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279085&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273414 378160673 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856329 CCOc1ncccc1-c1cc(NCc2ccc(nc2)C(F)F)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H26F2N6O/c1-5-33-24-17(7-6-10-27-24)19-11-20(22-21(30-19)15(4)31-32(22)14(2)3)29-13-16-8-9-18(23(25)26)28-12-16/h6-12,14,23H,5,13H2,1-4H3,(H,29,30) FDEJYPFAUDLEJD-UHFFFAOYSA-N 279086 N-[[6-(difluoromethyl)-3-pyridyl]methyl]-5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 117::US10512632, Example 117::US10766893, Example S117::US10806718, Example 117::US11026923, Example 117::US11491140, Example 117::US11634416, Example 117 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 18.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279086&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273416 378160674 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856332 CCOc1ncccc1-c1cc(NCc2ncccc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-17(9-7-12-26-24)18-13-19(27-14-20-21(31-5)10-8-11-25-20)23-22(28-18)16(4)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) CQZGCHPJVLXYPV-UHFFFAOYSA-N 279087 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(3-methoxy-2-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 118::US10512632, Example 118::US10766893, Example S118::US10806718, Example 118::US11026923, Example 118::US11491140, Example 118::US11634416, Example 118 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 13.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279087&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273417 378160675 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856335 CCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(nc(C)c2n1)C(C)CC 279088 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 119::US10034861, Example 120::US10512632, Example 120::US10618913, Example S120::US10766893, Example S120::US10806718, Example 120::US11026923, Example 120::US11634416, Example 120 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 12.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279088&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273415 378160676 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856338 CCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(nc(C)c2n1)C(C)CC 279088 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 119::US10034861, Example 120::US10512632, Example 120::US10618913, Example S120::US10766893, Example S120::US10806718, Example 120::US11026923, Example 120::US11634416, Example 120 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4.60 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279088&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273415 378160676 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856341 CCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C22H28N8O/c1-6-14(3)30-21-18(24-12-19-25-13-29(5)28-19)11-17(26-20(21)15(4)27-30)16-9-8-10-23-22(16)31-7-2/h8-11,13-14H,6-7,12H2,1-5H3,(H,24,26) RANZHWURGHEKDD-UHFFFAOYSA-N 279090 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 121::US10034861, Example 122::US10512632, Example 122::US10766893, Example S122::US10806718, Example 122::US11634416, Example 122 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4.00 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279090&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273418 378160677 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856344 CCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C22H28N8O/c1-6-14(3)30-21-18(24-12-19-25-13-29(5)28-19)11-17(26-20(21)15(4)27-30)16-9-8-10-23-22(16)31-7-2/h8-11,13-14H,6-7,12H2,1-5H3,(H,24,26) RANZHWURGHEKDD-UHFFFAOYSA-N 279090 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 121::US10034861, Example 122::US10512632, Example 122::US10766893, Example S122::US10806718, Example 122::US11634416, Example 122 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.20 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279090&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273418 378160677 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 856347 CCOc1ncccc1-c1cc(NCc2nnc(C)o2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C22H27N7O2/c1-6-13(3)29-21-18(24-12-19-27-26-15(5)31-19)11-17(25-20(21)14(4)28-29)16-9-8-10-23-22(16)30-7-2/h8-11,13H,6-7,12H2,1-5H3,(H,24,25) SJDHGTJKQKPRAR-UHFFFAOYSA-N 279092 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(5-methyl-1,3,4-oxadiazol-2-yl)methyl]-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 123::US10034861, Example 124::US10512632, Example 123::US10766893, Example S124::US10806718, Example 124::US11634416, Example 124 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 54.0 US Patent 10.7270/Q25T3NVN aid1804059 US10512632 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279092&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273419 378160678 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 878732 CC(C)Sc1c2c(nn1Cc1ccc(cc1)-c1cccc(F)n1)N1CC(C)(C)N=C1N(C)C2=O InChI=1S/C25H27FN6OS/c1-15(2)34-23-20-21(31-14-25(3,4)28-24(31)30(5)22(20)33)29-32(23)13-16-9-11-17(12-10-16)18-7-6-8-19(26)27-18/h6-12,15H,13-14H2,1-5H3 SLHRWMYBPUCIOM-UHFFFAOYSA-N 433320 2-(4-(6-fluoropyridin-2-yl(benzyl)-3-(isopropylthio)-5,7,7-trimethyl-7,8-dihydro-2H-imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(5H)-one::US10561656, Example 3 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 5.00 US Patent 10.7270/Q2ZP48HR aid1804208 US10561656 Li, P; Zheng, H; Zhao, J; Wennogle, LP INTRA-CELLULAR THERAPIES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=433320 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=433320&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 71114394 438642253 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 878734 CCSc1c2c(nn1Cc1ccc(cc1)-c1cccc(F)n1)N1[C@H]3CCC[C@H]3N=C1N(C)C2=O InChI=1S/C25H25FN6OS/c1-3-34-24-21-22(32-19-8-4-7-18(19)28-25(32)30(2)23(21)33)29-31(24)14-15-10-12-16(13-11-15)17-6-5-9-20(26)27-17/h5-6,9-13,18-19H,3-4,7-8,14H2,1-2H3/t18-,19+/m1/s1 HJLJTBLUYGEGCE-MOPGFXCFSA-N 433321 (6aR,9aS)-5,6a,7,8,9,9a-hexahydro-5-methyl-3-(ethylthio)-2-(4-(6-fluoropyridin-2-yl)benzyl)-cyclopent[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(2H)-one::US10561656, Example 3-A Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.50 US Patent 10.7270/Q2ZP48HR aid1804208 US10561656 Li, P; Zheng, H; Zhao, J; Wennogle, LP INTRA-CELLULAR THERAPIES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=433321 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=433321&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 71114599 438642254 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 878736 CC(C)Sc1c2c(nn1Cc1ccc(cc1)-c1cccc(F)n1)N1[C@H]3CCC[C@H]3N=C1N(C)C2=O InChI=1S/C26H27FN6OS/c1-15(2)35-25-22-23(33-20-8-4-7-19(20)29-26(33)31(3)24(22)34)30-32(25)14-16-10-12-17(13-11-16)18-6-5-9-21(27)28-18/h5-6,9-13,15,19-20H,4,7-8,14H2,1-3H3/t19-,20+/m1/s1 XRZKIVRXPTZVAL-UXHICEINSA-N 433322 (6aR,9aS)-5,6a,7,8,9,9a-hexahydro-5-methyl-3-(isopropylthio)-2-(4-(6-fluoropyridin-2-yl)benzyl)-cyclopent[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(2H)-one::US10561656, Example 3-B Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 6.00 US Patent 10.7270/Q2ZP48HR aid1804208 US10561656 Li, P; Zheng, H; Zhao, J; Wennogle, LP INTRA-CELLULAR THERAPIES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=433322 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=433322&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 71114387 438642255 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 893186 COc1ccc(CN2Cc3cccnc3OCCCCOc3ncccc3-c3cc2c2n(nc(C)c2n3)C(C)C)cc1 InChI=1S/C33H36N6O3/c1-22(2)39-31-29-19-28(36-30(31)23(3)37-39)27-10-8-16-35-33(27)42-18-6-5-17-41-32-25(9-7-15-34-32)21-38(29)20-24-11-13-26(40-4)14-12-24/h7-16,19,22H,5-6,17-18,20-21H2,1-4H3 YLWZUCCUGZMSMM-UHFFFAOYSA-N 438722 21-isopropyl-23-methyl-21H-6,11-dioxa-3-aza- 2(5,7)-pyrazolo[4,3-b]pyridina-1,5(3,2)- dipyridinacycloundecaphane::US10618913, Example 1 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 12.0 US Patent 10.7270/Q2NV9N80 aid1804346 US10618913 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=438722 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=438722&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138718710 439660297 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 893189 CC(C)n1nc(C)c2nc-3cc(NCc4cccnc4OCCCCCOc4ncccc-34)c12 InChI=1S/C26H30N6O2/c1-17(2)32-24-22-15-21(30-23(24)18(3)31-32)20-10-8-12-28-26(20)34-14-6-4-5-13-33-25-19(16-29-22)9-7-11-27-25/h7-12,15,17,29H,4-6,13-14,16H2,1-3H3 SIHCYERWXIEFJJ-UHFFFAOYSA-N 438723 21-isopropyl-23-methyl-21H-6,12-dioxa-3-aza- 2(5,7)-pyrazolo[4,3-b]pyridina-1,5(3,2)- dipyridinacyclododecaphane::US10618913, Example 2 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 18.0 US Patent 10.7270/Q2NV9N80 aid1804346 US10618913 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=438723 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=438723&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138718836 439660298 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 893192 CC(C)n1nc(C)c2nc-3cc(NCc4cccnc4OCCCOc4ncccc-34)c12 InChI=1S/C24H26N6O2/c1-15(2)30-22-20-13-19(28-21(22)16(3)29-30)18-8-5-10-26-24(18)32-12-6-11-31-23-17(14-27-20)7-4-9-25-23/h4-5,7-10,13,15,27H,6,11-12,14H2,1-3H3 JGQBOOQITKPWJR-UHFFFAOYSA-N 438724 21-isopropyl-23-methyl-21H-6,10-dioxa-3-aza- 2(5,7)-pyrazolo[4,3-b]pyridina-1,5(3,2)- dipyridinacyclodecaphane::US10618913, Example 3 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 38.0 US Patent 10.7270/Q2NV9N80 aid1804346 US10618913 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=438724 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=438724&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138718626 439660299 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 893195 CC(C)n1nc(C)c2nc-3cc(NCc4cccnc4OCCOCCOc4ncccc-34)c12 InChI=1S/C25H28N6O3/c1-16(2)31-23-21-14-20(29-22(23)17(3)30-31)19-7-5-9-27-25(19)34-13-11-32-10-12-33-24-18(15-28-21)6-4-8-26-24/h4-9,14,16,28H,10-13,15H2,1-3H3 IFJHYKXAQOIJLS-UHFFFAOYSA-N 438725 21-isopropyl-23-methyl-21H-6,9,12-trioxa-3- aza-2(5,7)-pyrazolo[4,3-b]pyridina-1,5(3,2)- dipyridinacyclododecaphane::US10618913, Example 4 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.60 US Patent 10.7270/Q2NV9N80 aid1804346 US10618913 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=438725 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=438725&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138718833 439660300 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 893198 CC(C)n1nc(C)c2nc-3cc(NCc4ccnn4CCCCCOc4ncccc-34)c12 InChI=1S/C24H29N7O/c1-16(2)31-23-21-14-20(28-22(23)17(3)29-31)19-8-7-10-25-24(19)32-13-6-4-5-12-30-18(15-26-21)9-11-27-30/h7-11,14,16,26H,4-6,12-13,15H2,1-3H3 POAGQXNCSDVZDH-UHFFFAOYSA-N 438735 21-isopropyl-23-methyl-21H,51H-11-oxa-3-aza- 2(5,7)-pyrazolo[4,3-b]pyridina-1(3,2)- pyridina-5(5,1)-pyrazolacycloundecaphane::US10618913, Example 5 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 25.0 US Patent 10.7270/Q2NV9N80 aid1804346 US10618913 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=438735 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=438735&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138718624 439660310 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 893201 CC(C)n1nc(C)c2nc-3cc(NCc4ncccc4OCCCCOc4ncccc-34)c12 InChI=1S/C25H28N6O2/c1-16(2)31-24-20-14-19(29-23(24)17(3)30-31)18-8-6-11-27-25(18)33-13-5-4-12-32-22-9-7-10-26-21(22)15-28-20/h6-11,14,16,28H,4-5,12-13,15H2,1-3H3 HHYVSMVGFQLTLE-UHFFFAOYSA-N 438746 21-isopropyl-23-methyl-21H-6,11-dioxa-3-aza- 2(5,7)-pyrazolo[4,3-b]pyridina-1(3,2),5(2,3)- dipyridinacycloundecaphane::US10618913, Example 6 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.470 US Patent 10.7270/Q2NV9N80 aid1804346 US10618913 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=438746 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=438746&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138718625 439660321 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 893204 Cc1nn(C)c2c3NCc4cccnc4OCCCCOc4ncccc4-c(c3)nc12 InChI=1S/C23H24N6O2/c1-15-20-21(29(2)28-15)19-13-18(27-20)17-8-6-10-25-23(17)31-12-4-3-11-30-22-16(14-26-19)7-5-9-24-22/h5-10,13,26H,3-4,11-12,14H2,1-2H3 OSXMMCYBFRYLSU-UHFFFAOYSA-N 438747 21,23-dimethyl-21H-6,11-dioxa-3-aza-2(5,7)- pyrazolo[4,3-b]pyridina-1,5(3,2)- dipyridinacycloundecaphane::US10618913, Example 7 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 428 US Patent 10.7270/Q2NV9N80 aid1804346 US10618913 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=438747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=438747&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138718631 439660322 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 893207 CCn1nc(C)c2nc-3cc(NCc4cccnc4OCCCCOc4ncccc-34)c12 InChI=1S/C24H26N6O2/c1-3-30-22-20-14-19(28-21(22)16(2)29-30)18-9-7-11-26-24(18)32-13-5-4-12-31-23-17(15-27-20)8-6-10-25-23/h6-11,14,27H,3-5,12-13,15H2,1-2H3 MWKYQHIHOQUVGV-UHFFFAOYSA-N 438748 21-ethyl-23-methyl-21H-6,11-dioxa-3-aza- 2(5,7)-pyrazolo[4,3-b]pyridina-1,5(3,2)- dipyridinacycloundecaphane::US10618913, Example 8 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 256 US Patent 10.7270/Q2NV9N80 aid1804346 US10618913 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=438748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=438748&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138718630 439660323 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 893210 CC(C)n1nc(C)c2nc-3cc(NCc4ccnn4CCCCOc4ncccc-34)c12 InChI=1S/C23H27N7O/c1-15(2)30-22-20-13-19(27-21(22)16(3)28-30)18-7-6-9-24-23(18)31-12-5-4-11-29-17(14-25-20)8-10-26-29/h6-10,13,15,25H,4-5,11-12,14H2,1-3H3 TZLKATCVHPXNFM-UHFFFAOYSA-N 438749 21-isopropyl-23-methyl-21H,51H-10-oxa-3-aza- 2(5,7)-pyrazolo[4,3-b]pyridina-1(3,2)- pyridina-5(5,1)-pyrazolacyclodecaphane::US10618913, Example 9 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 53.0 US Patent 10.7270/Q2NV9N80 aid1804346 US10618913 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=438749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=438749&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138718834 439660324 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 893213 CC(C)n1nc(C)c2nc-3cc(NCc4nccnc4OCCCCOc4ncccc-34)c12 InChI=1S/C24H27N7O2/c1-15(2)31-22-19-13-18(29-21(22)16(3)30-31)17-7-6-8-26-23(17)32-11-4-5-12-33-24-20(14-28-19)25-9-10-27-24/h6-10,13,15,28H,4-5,11-12,14H2,1-3H3 CXKLITMBWWCPKO-UHFFFAOYSA-N 438750 21-isopropyl-23-methyl-21H-6,11-dioxa-3-aza- 2(5,7)-pyrazolo[4,3-b]pyridina-5(2,3)- pyrazina-1(3,2)-pyridinacycloundecaphane::US10618913, Example 10 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 10.00 US Patent 10.7270/Q2NV9N80 aid1804346 US10618913 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=438750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=438750&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138718629 439660325 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 893216 CCOc1ncccc1-c1cc(NCc2nnc(C)o2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H25N7O2/c1-6-29-21-15(8-7-9-22-21)16-10-17(23-11-18-26-25-14(5)30-18)20-19(24-16)13(4)27-28(20)12(2)3/h7-10,12H,6,11H2,1-5H3,(H,23,24) XEBJMVLHZBRKST-UHFFFAOYSA-N 278971 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methyl-1,3,4-oxadiazol-2-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 1::US10512632, Example 1::US10618913, Example S1::US10766893, Example S1::US10806718, Example 1::US11026923, Example 1::US11491140, Example 1::US11634416, Example 1 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 18.0 US Patent 10.7270/Q2NV9N80 aid1804346 US10618913 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278971 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278971&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273299 378160560 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 893219 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C1CC1 InChI=1S/C22H25N7O/c1-4-30-22-17(6-5-9-23-22)18-10-19(24-11-15-12-25-28(3)13-15)21-20(26-18)14(2)27-29(21)16-7-8-16/h5-6,9-10,12-13,16H,4,7-8,11H2,1-3H3,(H,24,26) SVNBZNOJEMDHHP-UHFFFAOYSA-N 278982 1-cyclopropyl-5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 12::US10512632, Example 12::US10618913, Example S12::US10766893, Example S12::US10806718, Example 12::US11026923, Example 12::US11491140, Example 12 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 200 US Patent 10.7270/Q2NV9N80 aid1804346 US10618913 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278982&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273311 378160571 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 893222 CCCn1ncc2nc(cc(NCc3cnn(C)c3)c12)-c1cccnc1OCC InChI=1S/C21H25N7O/c1-4-9-28-20-18(23-11-15-12-24-27(3)14-15)10-17(26-19(20)13-25-28)16-7-6-8-22-21(16)29-5-2/h6-8,10,12-14H,4-5,9,11H2,1-3H3,(H,23,26) VBBYLKGVLRZVDT-UHFFFAOYSA-N 278983 5-(2-ethoxy-3-pyridyl)-N-[(1-methylpyrazol-4-yl)methyl]-1-propyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 13::US10512632, Example 13::US10618913, Example S13::US10766893, Example S13::US10806718, Example 13::US11026923, Example 13::US11491140, Example 13::US11634416, Example 13 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 90.0 US Patent 10.7270/Q2NV9N80 aid1804346 US10618913 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278983 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278983&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273312 378160572 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 893225 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(ncc2n1)C1COC1 InChI=1S/C21H23N7O2/c1-3-30-21-16(5-4-6-22-21)17-7-18(23-8-14-9-24-27(2)11-14)20-19(26-17)10-25-28(20)15-12-29-13-15/h4-7,9-11,15H,3,8,12-13H2,1-2H3,(H,23,26) BRAWZTIBDHEBNS-UHFFFAOYSA-N 278984 5-(2-ethoxypyridin-3-yl)-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1-(oxetan-3-yl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 14::US10512632, Example 14::US10618913, Example S14::US10766893, Example S14::US10806718, Example 14::US11026923, Example 14::US11491140, Example 14::US11634416, Example 14 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 450 US Patent 10.7270/Q2NV9N80 aid1804346 US10618913 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278984 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278984&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273313 378160573 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 893228 CCOc1ncccc1-c1cc(NCc2nccn2C)c2n(ncc2n1)C(C)C InChI=1S/C21H25N7O/c1-5-29-21-15(7-6-8-23-21)16-11-17(24-13-19-22-9-10-27(19)4)20-18(26-16)12-25-28(20)14(2)3/h6-12,14H,5,13H2,1-4H3,(H,24,26) XRIYYPDCPKIHRW-UHFFFAOYSA-N 278987 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimidazol-2-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 17::US10512632, Example 17::US10618913, Example S17::US10766893, Example S17::US10806718, Example 17::US11026923, Example 17::US11491140, Example 17::US11634416, Example 17 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 700 US Patent 10.7270/Q2NV9N80 aid1804346 US10618913 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278987 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278987&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273316 378160576 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 893231 CCOc1ncccc1-c1cc(NCc2cccc(C)c2)c2n(ncc2n1)C(C)C InChI=1S/C24H27N5O/c1-5-30-24-19(10-7-11-25-24)20-13-21(26-14-18-9-6-8-17(4)12-18)23-22(28-20)15-27-29(23)16(2)3/h6-13,15-16H,5,14H2,1-4H3,(H,26,28) NOGPVEPEDSPNHF-UHFFFAOYSA-N 278993 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-(m-tolylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 23::US10512632, Example 23::US10618913, Example S23::US10766893, Example S23::US10806718, Example 23::US11026923, Example 23::US11491140, Example 23::US11634416, Example 23 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 240 US Patent 10.7270/Q2NV9N80 aid1804346 US10618913 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278993&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273321 378160582 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 893234 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(CC)ncc2n1 InChI=1S/C20H23N7O/c1-4-27-19-17(22-10-14-11-23-26(3)13-14)9-16(25-18(19)12-24-27)15-7-6-8-21-20(15)28-5-2/h6-9,11-13H,4-5,10H2,1-3H3,(H,22,25) GDQVLYVPAWKIKI-UHFFFAOYSA-N 424936 US10512632, Example 26::US10618913, Example S26::US10766893, Example S26::US10806718, Example 26::US11026923, Example 26::US11491140, Example 26::US11634416, Example 26 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 140 US Patent 10.7270/Q2NV9N80 aid1804346 US10618913 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=424936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=424936&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138536209 434150491 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 893237 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(C)nc(C)c2n1 InChI=1S/C20H23N7O/c1-5-28-20-15(7-6-8-21-20)16-9-17(22-10-14-11-23-26(3)12-14)19-18(24-16)13(2)25-27(19)4/h6-9,11-12H,5,10H2,1-4H3,(H,22,24) GGQMHLLGYDUHDQ-UHFFFAOYSA-N 278998 5-(2-ethoxy-3-pyridyl)-1,3-dimethyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 28::US10512632, Example 28::US10618913, Example S28::US10766893, Example S28::US10806718, Example 28::US11026923, Example 28::US11491140, Example 28::US11634416, Example 28 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 550 US Patent 10.7270/Q2NV9N80 aid1804346 US10618913 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278998 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278998&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273327 378160587 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 893240 CCOc1ncccc1-c1cc(NCc2nc(C)cs2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6OS/c1-6-29-22-16(8-7-9-23-22)17-10-18(24-11-19-25-14(4)12-30-19)21-20(26-17)15(5)27-28(21)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,24,26) WFSFSRAGPIZNCC-UHFFFAOYSA-N 278999 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(4-methylthiazol-2-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 29::US10512632, Example 29::US10618913, Example S162::US10766893, Example S29::US10806718, Example 29::US11026923, Example 29::US11491140, Example 29::US11634416, Example 29 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 27.0 US Patent 10.7270/Q2NV9N80 aid1804346 US10618913 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278999 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278999&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273328 378160588 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 893243 CCOc1ncccc1-c1cc(NCc2ccccc2)c2n(ncc2n1)C(C)C InChI=1S/C23H25N5O/c1-4-29-23-18(11-8-12-24-23)19-13-20(25-14-17-9-6-5-7-10-17)22-21(27-19)15-26-28(22)16(2)3/h5-13,15-16H,4,14H2,1-3H3,(H,25,27) CAHURFTWFHHOPU-UHFFFAOYSA-N 279011 N-benzyl-5-(2-ethoxy-3-pyridyl)-1-isopropyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 41::US10512632, Example 41::US10618913, Example S41::US10766893, Example S41::US10806718, Example 41::US11026923, Example 41::US11634416, Example 41 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 500 US Patent 10.7270/Q2NV9N80 aid1804346 US10618913 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279011 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279011&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273336 378160600 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 893246 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(CC)nc(C)c2n1 InChI=1S/C21H25N7O/c1-5-28-20-18(23-11-15-12-24-27(4)13-15)10-17(25-19(20)14(3)26-28)16-8-7-9-22-21(16)29-6-2/h7-10,12-13H,5-6,11H2,1-4H3,(H,23,25) ALQSQGPOANFHOP-UHFFFAOYSA-N 279018 5-(2-ethoxypyridin-3-yl)-1-ethyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 48::US10512632, Example 48::US10618913, Example S48::US10766893, Example S48::US10806718, Example 48::US11026923, Example 48::US11491140, Example 48::US11634416, Example 48 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 38.0 US Patent 10.7270/Q2NV9N80 aid1804346 US10618913 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279018&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273347 378160607 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 893249 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1cn(C)nc1C InChI=1S/C20H26N8/c1-12(2)28-20-18(21-8-15-9-22-26(5)10-15)7-17(23-19(20)14(4)25-28)16-11-27(6)24-13(16)3/h7,9-12H,8H2,1-6H3,(H,21,23) SZOKENQFAYLAJE-UHFFFAOYSA-N 279031 5-(1,3-dimethylpyrazol-4-yl)-1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 61::US10512632, Example 61::US10618913, Example S61::US10766893, Example S61::US10806718, Example 61::US11491140, Example 61::US11634416, Example 61 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 550 US Patent 10.7270/Q2NV9N80 aid1804346 US10618913 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279031&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273370 378160620 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 893252 CCOc1ncccc1-c1cc(NCc2ccn(C)n2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C23H29N7O/c1-6-15(3)30-22-20(25-14-17-10-12-29(5)28-17)13-19(26-21(22)16(4)27-30)18-9-8-11-24-23(18)31-7-2/h8-13,15H,6-7,14H2,1-5H3,(H,25,26) GUZUXYPWYDLGJF-UHFFFAOYSA-N 279037 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]-N-[(1-methylpyrazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 67::US10512632, Example 67::US10618913, Example S67::US10766893, Example S67::US10806718, Example 67::US11634416, Example 67 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 9.60 US Patent 10.7270/Q2NV9N80 aid1804346 US10618913 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279037 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279037&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273371 378160626 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 893255 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(ncc2n1)C(C)CC InChI=1S/C22H27N7O/c1-5-15(3)29-21-19(24-11-16-12-25-28(4)14-16)10-18(27-20(21)13-26-29)17-8-7-9-23-22(17)30-6-2/h7-10,12-15H,5-6,11H2,1-4H3,(H,24,27) PNGBBNJWUZFNIY-UHFFFAOYSA-N 279039 5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine, enantiomer 1::US10034861, Example 69::US10034861, Example 70::US10512632, Example 70::US10618913, Example S69::US10766893, Example S70::US10806718, Example 70::US11634416, Example 70 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 14.0 US Patent 10.7270/Q2NV9N80 aid1804346 US10618913 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279039&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273366 378160628 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 893258 CCOc1ncccc1-c1cc(NCc2csc(C)n2)c2n(nc(C)c2n1)C1COC1 InChI=1S/C22H24N6O2S/c1-4-30-22-17(6-5-7-23-22)18-8-19(24-9-15-12-31-14(3)25-15)21-20(26-18)13(2)27-28(21)16-10-29-11-16/h5-8,12,16H,4,9-11H2,1-3H3,(H,24,26) BSSGJYYHYVLYMA-UHFFFAOYSA-N 279082 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(2-methylthiazol-4-yl)methyl]-1-(oxetan-3-yl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 113::US10512632, Example 113::US10618913, Example S113::US10766893, Example S113::US10806718, Example 113::US11026923, Example 113::US11491140, Example 113::US11634416, Example 113 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 110 US Patent 10.7270/Q2NV9N80 aid1804346 US10618913 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279082&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273410 378160670 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 893261 CCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(nc(C)c2n1)C(C)CC 279088 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 119::US10034861, Example 120::US10512632, Example 120::US10618913, Example S120::US10766893, Example S120::US10806718, Example 120::US11026923, Example 120::US11634416, Example 120 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4.60 US Patent 10.7270/Q2NV9N80 aid1804346 US10618913 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279088&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273415 378160676 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 893264 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1nccs1 InChI=1S/C18H21N7S/c1-11(2)25-17-14(20-8-13-9-21-24(4)10-13)7-15(18-19-5-6-26-18)22-16(17)12(3)23-25/h5-7,9-11H,8H2,1-4H3,(H,20,22) TVGMRVMYCDHOEG-UHFFFAOYSA-N 279116 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-thiazol-2-yl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 147::US10512632, Example 147::US10618913, Example S147::US10766893, Example S147::US10806718, Example 147::US11026923, Example 147::US11491140, Example 147::US11634416, Example 147 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 12.0 US Patent 10.7270/Q2NV9N80 aid1804346 US10618913 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279116&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273437 378160698 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 893267 CCOc1ncccc1-c1cc(NCc2ncnn2C)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-6-30-21-15(8-7-9-22-21)16-10-17(23-11-18-24-12-25-28(18)5)20-19(26-16)14(4)27-29(20)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,23,26) DSJWNAKWTOCISO-UHFFFAOYSA-N 425070 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methyl-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10512632, Example 161::US10618913, Example S161::US10766893, Example S161::US10806718, Example 161::US11026923, Example 161::US11491140, Example 162::US11634416, Example 161 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 60.0 US Patent 10.7270/Q2NV9N80 aid1804346 US10618913 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=425070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=425070&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138536279 434150493 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 893270 CCOc1ncccc1-c1cc(NCc2nc(C)cs2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6OS/c1-6-29-22-16(8-7-9-23-22)17-10-18(24-11-19-25-14(4)12-30-19)21-20(26-17)15(5)27-28(21)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,24,26) WFSFSRAGPIZNCC-UHFFFAOYSA-N 278999 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(4-methylthiazol-2-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 29::US10512632, Example 29::US10618913, Example S162::US10766893, Example S29::US10806718, Example 29::US11026923, Example 29::US11491140, Example 29::US11634416, Example 29 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 100.0 US Patent 10.7270/Q2NV9N80 aid1804346 US10618913 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278999 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278999&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273328 378160588 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 893273 CCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(nc(C)c2n1)C1COC1 InChI=1S/C21H24N8O2/c1-4-31-21-15(6-5-7-22-21)16-8-17(23-9-18-24-12-28(3)27-18)20-19(25-16)13(2)26-29(20)14-10-30-11-14/h5-8,12,14H,4,9-11H2,1-3H3,(H,23,25) KHCSAUOHEOUDEI-UHFFFAOYSA-N 279132 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]-1-(oxetan-3-yl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 163::US10512632, Example 163::US10618913, Example S163::US10766893, Example S163::US10806718, Example 163::US11026923, Example 163::US11491140, Example 163::US11634416, Example 163 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 120 US Patent 10.7270/Q2NV9N80 aid1804346 US10618913 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279132&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273457 378160713 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 893276 CCOc1ncccc1-c1cc(N(Cc2cnn(c2)C(F)F)Cc2ccc(OC)cc2)c2n(nc(C)c2n1)C(C)C InChI=1S/C30H33F2N7O2/c1-6-41-29-24(8-7-13-33-29)25-14-26(28-27(35-25)20(4)36-39(28)19(2)3)37(16-21-9-11-23(40-5)12-10-21)17-22-15-34-38(18-22)30(31)32/h7-15,18-19,30H,6,16-17H2,1-5H3 UXTFTMXAFOTATJ-UHFFFAOYSA-N 279134 N-[[1-(difluoromethyl)pyrazol-4-yl]methyl]-5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 165::US10512632, Example 165::US10618913, Example S165::US11026923, Example 165::US11491140, Example 165::US11634416, Example 165 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 73.0 US Patent 10.7270/Q2NV9N80 aid1804346 US10618913 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279134&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273284 378160715 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 893279 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1ncco1 InChI=1S/C18H21N7O/c1-11(2)25-17-14(20-8-13-9-21-24(4)10-13)7-15(18-19-5-6-26-18)22-16(17)12(3)23-25/h5-7,9-11H,8H2,1-4H3,(H,20,22) IMKYKBMLZRNQRQ-UHFFFAOYSA-N 279137 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-oxazol-2-yl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 168::US10512632, Example 168::US10618913, Example S168::US10766893, Example S168::US10806718, Example 168::US11026923, Example 168::US11491140, Example 168::US11634416, Example 168 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 14.0 US Patent 10.7270/Q2NV9N80 aid1804346 US10618913 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279137&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273461 378160718 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 893282 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1cnnn1C InChI=1S/C18H23N9/c1-11(2)27-18-15(19-7-13-8-21-25(4)10-13)6-14(16-9-20-24-26(16)5)22-17(18)12(3)23-27/h6,8-11H,7H2,1-5H3,(H,19,22) YPYKZBZKFWCVCN-UHFFFAOYSA-N 279138 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-(3-methyltriazol-4-yl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 169::US10512632, Example 169::US10618913, Example S169::US10766893, Example S169::US10806718, Example 169::US11026923, Example 169::US11491140, Example 169::US11634416, Example 169 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 610 US Patent 10.7270/Q2NV9N80 aid1804346 US10618913 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279138&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273462 378160719 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 893285 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C(F)F)c2n1)C(C)C InChI=1S/C22H25F2N7O/c1-5-32-22-15(7-6-8-25-22)16-9-17(26-10-14-11-27-30(4)12-14)20-18(28-16)19(21(23)24)29-31(20)13(2)3/h6-9,11-13,21H,5,10H2,1-4H3,(H,26,28) YFAHCXPQQYYPCW-UHFFFAOYSA-N 279153 3-(difluoromethyl)-5-(2-ethoxypyridin-3-yl)-1-isopropyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 184::US10512632, Example 184::US10618913, Example S184::US10766893, Example S184::US10806718, Example 184::US11491140, Example 184::US11634416, Example 184 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 13.0 US Patent 10.7270/Q2NV9N80 aid1804346 US10618913 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279153&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273473 378160730 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 893288 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1ncnn1C InChI=1S/C18H23N9/c1-11(2)27-17-14(19-7-13-8-21-25(4)9-13)6-15(18-20-10-22-26(18)5)23-16(17)12(3)24-27/h6,8-11H,7H2,1-5H3,(H,19,23) KYLSIDIKSXHHCI-UHFFFAOYSA-N 279164 1-isopropyl-3-methyl-5-(1-methyl-1H-1,2,4-triazol-5-yl)-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 195::US10512632, Example 195::US10618913, Example S195::US10766893, Example S195::US10806718, Example 195::US11026923, Example 195::US11634416, Example 195 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 420 US Patent 10.7270/Q2NV9N80 aid1804346 US10618913 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279164&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273486 378160741 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 893291 CCOc1ncccc1-c1cc(NCc2cccnc2OC)c2n(nc(C)c2n1)C1COC1 InChI=1S/C24H26N6O3/c1-4-33-24-18(8-6-10-26-24)19-11-20(27-12-16-7-5-9-25-23(16)31-3)22-21(28-19)15(2)29-30(22)17-13-32-14-17/h5-11,17H,4,12-14H2,1-3H3,(H,27,28) GRFJYHDUOKDAKO-UHFFFAOYSA-N 279166 5-(2-ethoxy-3-pyridyl)-N-[(2-methoxy-3-pyridyl)methyl]-3-methyl-1-(oxetan-3-yl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 197::US10512632, Example 197::US10618913, Example S197::US10766893, Example S197::US10806718, Example 197::US11491140, Example 197::US11634416, Example 197 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 190 US Patent 10.7270/Q2NV9N80 aid1804346 US10618913 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279166&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273484 378160743 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 893294 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(CF)c2n1)C(C)C InChI=1S/C22H26FN7O/c1-5-31-22-16(7-6-8-24-22)17-9-18(25-11-15-12-26-29(4)13-15)21-20(27-17)19(10-23)28-30(21)14(2)3/h6-9,12-14H,5,10-11H2,1-4H3,(H,25,27) CRFWOMGBISLKHY-UHFFFAOYSA-N 279168 5-(2-ethoxypyridin-3-yl)-3-(fluoromethyl)-1-isopropyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 199::US10512632, Example 199::US10618913, Example S199::US10766893, Example S199::US10806718, Example 199::US11026923, Example 199::US11491140, Example 199::US11634416, Example 199 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 7.40 US Patent 10.7270/Q2NV9N80 aid1804346 US10618913 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279168&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273487 378160745 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 893297 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1ocnc1C InChI=1S/C19H23N7O/c1-11(2)26-18-15(20-7-14-8-22-25(5)9-14)6-16(19-13(4)21-10-27-19)23-17(18)12(3)24-26/h6,8-11H,7H2,1-5H3,(H,20,23) JVGYDVFOXCBHRN-UHFFFAOYSA-N 279169 1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-5-(4-methyloxazol-5-yl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 200::US10512632, Example 200::US10618913, Example S200::US10766893, Example S200::US10806718, Example 200::US11026923, Example 200::US11491140, Example 200::US11634416, Example 200 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 98.0 US Patent 10.7270/Q2NV9N80 aid1804346 US10618913 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279169&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273489 378160746 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51223690 COc1ccccc1NC(=O)C1Cc2cc(OC3CCCC3)c(OC)cc2C(=N1)c1ccccc1 InChI=1S/C29H30N2O4/c1-33-25-15-9-8-14-23(25)31-29(32)24-16-20-17-27(35-21-12-6-7-13-21)26(34-2)18-22(20)28(30-24)19-10-4-3-5-11-19/h3-5,8-11,14-15,17-18,21,24H,6-7,12-13,16H2,1-2H3,(H,31,32) UIIDPEAWDOFXDG-UHFFFAOYSA-N 50502852 CHEMBL4464755 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >200000 ChEMBL 10.1016/j.bmcl.2019.126720 10.7270/Q25X2D6W 31610942 Liao, Y; Jia, X; Tang, Y; Li, S; Zang, Y; Wang, L; Cui, ZN; Song, G South China Agricultural University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50502852 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50502852&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 155530589 440711437 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967139 CCOc1ncccc1-c1cc(NCc2nnc(C)o2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H25N7O2/c1-6-29-21-15(8-7-9-22-21)16-10-17(23-11-18-26-25-14(5)30-18)20-19(24-16)13(4)27-28(20)12(2)3/h7-10,12H,6,11H2,1-5H3,(H,23,24) XEBJMVLHZBRKST-UHFFFAOYSA-N 278971 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methyl-1,3,4-oxadiazol-2-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 1::US10512632, Example 1::US10618913, Example S1::US10766893, Example S1::US10806718, Example 1::US11026923, Example 1::US11491140, Example 1::US11634416, Example 1 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 18.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278971 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278971&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273299 378160560 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51288140 COc1cc2CCN(C=O)[C@@H](CCc3c[nH]c4cc(C)ccc34)c2cc1OC InChI=1S/C23H26N2O3/c1-15-4-6-18-17(13-24-20(18)10-15)5-7-21-19-12-23(28-3)22(27-2)11-16(19)8-9-25(21)14-26/h4,6,10-14,21,24H,5,7-9H2,1-3H3/t21-/m0/s1 OIDQRHGTWLIKKZ-NRFANRHFSA-N 50525165 CHEMBL4527894 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >50000 ChEMBL 10.1021/acs.jmedchem.9b00518 10.7270/Q2S75KRZ 31099559 Zhang, X; Dong, G; Li, H; Chen, W; Li, J; Feng, C; Gu, Z; Zhu, F; Zhang, R; Li, M; Tang, W; Liu, H; Xu, Y Shanghai Institute of Materia Medica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525165&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search AKO 138393292 440733747 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954898 CCOc1ncccc1-c1cc(NCc2cc(C)[nH]n2)c2n(nc(C)c2n1)C(C)CC 279100 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]-N-[(5-methyl-1H-pyrazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 131::US10512632, Example 131::US10766893, Example S131::US10806718, Example 131::US11634416, Example 131 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.350 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279100 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279100&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273426 378160685 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954901 CCOc1ncccc1-c1cc(NCc2cn(C)cn2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C23H29N7O/c1-6-15(3)30-22-20(25-12-17-13-29(5)14-26-17)11-19(27-21(22)16(4)28-30)18-9-8-10-24-23(18)31-7-2/h8-11,13-15H,6-7,12H2,1-5H3,(H,25,27) NIXYLBKMUOTNON-UHFFFAOYSA-N 279101 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(1-methylimidazol-4-yl)methyl]-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 132::US10512632, Example 132::US10766893, Example S132::US10806718, Example 132::US11634416, Example 132 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.140 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279101&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273427 378160686 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954904 CCOc1ncccc1-c1cc(NCc2cnc(C)o2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C23H28N6O2/c1-6-14(3)29-22-20(26-13-17-12-25-16(5)31-17)11-19(27-21(22)15(4)28-29)18-9-8-10-24-23(18)30-7-2/h8-12,14H,6-7,13H2,1-5H3,(H,26,27) ZJGPWXQIKUCOGR-UHFFFAOYSA-N 279102 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(2-methyloxazol-5-yl)methyl]-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 133::US10512632, Example 133::US10766893, Example S133::US10806718, Example 133::US11634416, Example 133 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 11.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279102&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273428 378160687 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954907 CCCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C23H30N8O/c1-6-11-32-23-17(9-8-10-24-23)18-12-19(25-13-20-26-14-30(5)29-20)22-21(27-18)16(4)28-31(22)15(3)7-2/h8-10,12,14-15H,6-7,11,13H2,1-5H3,(H,25,27) SXNFSKBWTTYFLI-UHFFFAOYSA-N 279103 3-methyl-1-[1-methylpropyl]-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]-5-(2-propoxy-3-pyridyl)pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 134::US10512632, Example 134::US10766893, Example S134::US10806718, Example 134::US11491140, Example 134::US11634416, Example 134 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.960 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279103&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273429 378160688 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954910 CCCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(nc(C)c2n1)C(C)CC 279104 3-methyl-1-[1-methylpropyl]-5-(2-propoxy-3-pyridyl)-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 135::US10512632, Example 135::US10766893, Example S135::US10806718, Example 135::US11491140, Example 135::US11634416, Example 135 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.90 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279104&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273430 378160689 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954913 CCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(ncc2n1)C(C)CC 279105 5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine, enantiomer 1::US10034861, Example 136::US10034861, Example 137::US10512632, Example 137::US10766893, Example S137::US10806718, Example 137::US11026923, Example 137::US11491140, Example 137::US11634416, Example 137 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 62.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279105&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273431 378160690 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954916 CCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(ncc2n1)C(C)CC 279105 5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine, enantiomer 1::US10034861, Example 136::US10034861, Example 137::US10512632, Example 137::US10766893, Example S137::US10806718, Example 137::US11026923, Example 137::US11491140, Example 137::US11634416, Example 137 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 180 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279105&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273431 378160690 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954919 CCOc1ncccc1-c1cc(NCc2nnc(C)o2)c2n(ncc2n1)C(C)CC InChI=1S/C21H25N7O2/c1-5-13(3)28-20-17(23-12-19-27-26-14(4)30-19)10-16(25-18(20)11-24-28)15-8-7-9-22-21(15)29-6-2/h7-11,13H,5-6,12H2,1-4H3,(H,23,25) BIQGCKNODPBTSC-UHFFFAOYSA-N 279107 5-(2-ethoxy-3-pyridyl)-N-[(5-methyl-1,3,4-oxadiazol-2-yl)methyl]-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 138::US10034861, Example 139::US10512632, Example 139::US10766893, Example S139::US10806718, Example 139::US11026923, Example 139::US11491140, Example 139::US11634416, Example 139 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 93.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279107&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273432 378160691 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954922 CCOc1ncccc1-c1cc(NCc2nnc(C)o2)c2n(ncc2n1)C(C)CC InChI=1S/C21H25N7O2/c1-5-13(3)28-20-17(23-12-19-27-26-14(4)30-19)10-16(25-18(20)11-24-28)15-8-7-9-22-21(15)29-6-2/h7-11,13H,5-6,12H2,1-4H3,(H,23,25) BIQGCKNODPBTSC-UHFFFAOYSA-N 279107 5-(2-ethoxy-3-pyridyl)-N-[(5-methyl-1,3,4-oxadiazol-2-yl)methyl]-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 138::US10034861, Example 139::US10512632, Example 139::US10766893, Example S139::US10806718, Example 139::US11026923, Example 139::US11491140, Example 139::US11634416, Example 139 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 330 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279107&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273432 378160691 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954925 CCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(ncc2n1)C(C)CC InChI=1S/C21H26N8O/c1-5-14(3)29-20-17(23-12-19-24-13-28(4)27-19)10-16(26-18(20)11-25-29)15-8-7-9-22-21(15)30-6-2/h7-11,13-14H,5-6,12H2,1-4H3,(H,23,26) OKQUCPHNAVGTKM-UHFFFAOYSA-N 279109 5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 140::US10034861, Example 141::US10512632, Example 141::US10766893, Example S141::US10806718, Example 141::US11026923, Example 141::US11491140, Example 141::US11634416, Example 141 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 32.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279109&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273433 378160692 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954928 CCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(ncc2n1)C(C)CC InChI=1S/C21H26N8O/c1-5-14(3)29-20-17(23-12-19-24-13-28(4)27-19)10-16(26-18(20)11-25-29)15-8-7-9-22-21(15)30-6-2/h7-11,13-14H,5-6,12H2,1-4H3,(H,23,26) OKQUCPHNAVGTKM-UHFFFAOYSA-N 279109 5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 140::US10034861, Example 141::US10512632, Example 141::US10766893, Example S141::US10806718, Example 141::US11026923, Example 141::US11491140, Example 141::US11634416, Example 141 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 44.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279109&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273433 378160692 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954931 CCCOc1ncccc1-c1cc(NCc2cn(C)cn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H29N7O/c1-6-10-31-23-18(8-7-9-24-23)19-11-20(25-12-17-13-29(5)14-26-17)22-21(27-19)16(4)28-30(22)15(2)3/h7-9,11,13-15H,6,10,12H2,1-5H3,(H,25,27) KLLVPOPJMWWQFO-UHFFFAOYSA-N 279111 1-isopropyl-3-methyl-N-[(1-methylimidazol-4-yl)methyl]-5-(2-propoxy-3-pyridyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 142::US10512632, Example 142::US10766893, Example S142::US10806718, Example 142::US11491140, Example 142::US11634416, Example 142 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.260 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279111&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273434 378160693 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954934 CCCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H27N7O/c1-5-11-30-22-17(7-6-9-23-22)18-12-19(24-13-16-8-10-25-27-16)21-20(26-18)15(4)28-29(21)14(2)3/h6-10,12,14H,5,11,13H2,1-4H3,(H,24,26)(H,25,27) WVFCCHYAETYKIF-UHFFFAOYSA-N 279112 1-isopropyl-3-methyl-5-(2-propoxy-3-pyridyl)-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 143::US10512632, Example 143::US10766893, Example S143::US10806718, Example 143::US11026923, Example 143::US11491140, Example 143::US11634416, Example 143 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 3.80 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279112&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273435 378160694 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954937 CCOc1ncccc1-c1cc(NCc2nc[nH]n2)c2n(nc(C)c2n1)C(C)CC 279113 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]-N-(1H-1,2,4-triazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 144::US10512632, Example 144::US10766893, Example S144::US10806718, Example 144::US11026923, Example 144::US11491140, Example 144::US11634416, Example 144 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 14.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279113&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273438 378160695 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954940 CCCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H28N8O/c1-6-10-31-22-16(8-7-9-23-22)17-11-18(24-12-19-25-13-29(5)28-19)21-20(26-17)15(4)27-30(21)14(2)3/h7-9,11,13-14H,6,10,12H2,1-5H3,(H,24,26) ROWMNTAKQCZGNZ-UHFFFAOYSA-N 279114 1-isopropyl-3-methyl-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]-5-(2-propoxy-3-pyridyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 145::US10512632, Example 145::US10766893, Example S145::US10806718, Example 145::US11026923, Example 145::US11491140, Example 145::US11634416, Example 145 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.410 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279114&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273436 378160696 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954943 CCCOc1ncccc1-c1cc(NCc2nc[nH]n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-5-9-30-21-15(7-6-8-22-21)16-10-17(23-11-18-24-12-25-27-18)20-19(26-16)14(4)28-29(20)13(2)3/h6-8,10,12-13H,5,9,11H2,1-4H3,(H,23,26)(H,24,25,27) RLGQIPCFRYRCDL-UHFFFAOYSA-N 279115 1-isopropyl-3-methyl-5-(2-propoxy-3-pyridyl)-N-(1H-1,2,4-triazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 146::US10512632, Example 146::US10766893, Example S146::US10806718, Example 146::US11026923, Example 146::US11491140, Example 146::US11634416, Example 146 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 3.90 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279115&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273440 378160697 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954946 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1nccs1 InChI=1S/C18H21N7S/c1-11(2)25-17-14(20-8-13-9-21-24(4)10-13)7-15(18-19-5-6-26-18)22-16(17)12(3)23-25/h5-7,9-11H,8H2,1-4H3,(H,20,22) TVGMRVMYCDHOEG-UHFFFAOYSA-N 279116 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-thiazol-2-yl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 147::US10512632, Example 147::US10618913, Example S147::US10766893, Example S147::US10806718, Example 147::US11026923, Example 147::US11491140, Example 147::US11634416, Example 147 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 12.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279116&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273437 378160698 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954949 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1ncc(C)s1 InChI=1S/C19H23N7S/c1-11(2)26-18-15(20-8-14-9-22-25(5)10-14)6-16(19-21-7-12(3)27-19)23-17(18)13(4)24-26/h6-7,9-11H,8H2,1-5H3,(H,20,23) ACZBEPYVSHJPFB-UHFFFAOYSA-N 279117 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-(5-methylthiazol-2-yl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 148::US10512632, Example 148::US10766893, Example S148::US10806718, Example 148::US11026923, Example 148::US11491140, Example 148::US11634416, Example 148 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 110 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279117&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273439 378160699 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954952 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1nc(C)cs1 InChI=1S/C19H23N7S/c1-11(2)26-18-15(20-7-14-8-21-25(5)9-14)6-16(19-22-12(3)10-27-19)23-17(18)13(4)24-26/h6,8-11H,7H2,1-5H3,(H,20,23) HCLONMUJAHJFIH-UHFFFAOYSA-N 279118 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-(4-methylthiazol-2-yl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 149::US10512632, Example 149::US10766893, Example S149::US10806718, Example 149::US11026923, Example 149::US11491140, Example 149::US11634416, Example 149 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 29.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279118&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273441 378160700 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954955 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)N1CC(C)OC1=O InChI=1S/C19H25N7O2/c1-11(2)26-18-15(20-7-14-8-21-24(5)10-14)6-16(22-17(18)13(4)23-26)25-9-12(3)28-19(25)27/h6,8,10-12H,7,9H2,1-5H3,(H,20,22) YBJPEIIVVVNBPC-UHFFFAOYSA-N 279119 3-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]-5-methyl-oxazolidin-2-one::US10034861, Example 150::US10512632, Example 150::US10766893, Example S150::US10806718, Example 150::US11026923, Example 150::US11491140, Example 150::US11634416, Example 150 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 44.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279119&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273442 378160701 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954958 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)N1CCOC1=O InChI=1S/C18H23N7O2/c1-11(2)25-17-14(19-8-13-9-20-23(4)10-13)7-15(21-16(17)12(3)22-25)24-5-6-27-18(24)26/h7,9-11H,5-6,8H2,1-4H3,(H,19,21) CBOOBJUJEUVRPS-UHFFFAOYSA-N 279120 3-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]oxazolidin-2-one::US10034861, Example 151::US10512632, Example 151::US10766893, Example S151::US10806718, Example 151::US11026923, Example 151::US11491140, Example 151::US11634416, Example 151 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 10.00 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279120&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273443 378160702 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954961 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)N1CCC1=O InChI=1S/C18H23N7O/c1-11(2)25-18-14(19-8-13-9-20-23(4)10-13)7-15(24-6-5-16(24)26)21-17(18)12(3)22-25/h7,9-11H,5-6,8H2,1-4H3,(H,19,21) SLJWZSCTWDVJBR-UHFFFAOYSA-N 279121 1-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]azetidin-2-one::US10034861, Example 152::US10512632, Example 152::US10766893, Example S152::US10806718, Example 152::US11026923, Example 152::US11491140, Example 152::US11634416, Example 152 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 48.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279121&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273444 378160703 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954964 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)N1CCN(C1=O)C(C)(C)C InChI=1S/C22H32N8O/c1-14(2)30-20-17(23-11-16-12-24-27(7)13-16)10-18(25-19(20)15(3)26-30)28-8-9-29(21(28)31)22(4,5)6/h10,12-14H,8-9,11H2,1-7H3,(H,23,25) KIFHGJKUXDTDBI-UHFFFAOYSA-N 279122 1-tert-butyl-3-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]imidazolidin-2-one::US10034861, Example 153::US10512632, Example 153::US10766893, Example S153::US10806718, Example 153::US11026923, Example 153::US11491140, Example 153::US11634416, Example 153 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 130 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279122&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273445 378160704 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954967 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)N1CCCC1=O InChI=1S/C19H25N7O/c1-12(2)26-19-15(20-9-14-10-21-24(4)11-14)8-16(22-18(19)13(3)23-26)25-7-5-6-17(25)27/h8,10-12H,5-7,9H2,1-4H3,(H,20,22) CXGJWWJDXYZFFZ-UHFFFAOYSA-N 279123 1-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]pyrrolidin-2-one::US10034861, Example 154::US10512632, Example 154::US10766893, Example S154::US10806718, Example 154::US11026923, Example 154::US11491140, Example 154::US11634416, Example 154 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 26.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279123&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273446 378160705 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954970 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)N1C(C)COC1=O InChI=1S/C19H25N7O2/c1-11(2)26-18-15(20-7-14-8-21-24(5)9-14)6-16(22-17(18)13(4)23-26)25-12(3)10-28-19(25)27/h6,8-9,11-12H,7,10H2,1-5H3,(H,20,22) DXKZTPARVQEQMA-UHFFFAOYSA-N 279124 3-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]-4-methyl-oxazolidin-2-one::US10034861, Example 155::US10512632, Example 155::US10766893, Example S155::US10806718, Example 155::US11026923, Example 155::US11491140, Example 155::US11634416, Example 155 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.20 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279124&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273447 378160706 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954973 CCC1COC(=O)N1c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C20H27N7O2/c1-6-15-11-29-20(28)26(15)17-7-16(21-8-14-9-22-25(5)10-14)19-18(23-17)13(4)24-27(19)12(2)3/h7,9-10,12,15H,6,8,11H2,1-5H3,(H,21,23) CVOILQIVJFYVAQ-UHFFFAOYSA-N 279125 4-ethyl-3-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]oxazolidin-2-one::US10034861, Example 156::US10512632, Example 156::US10766893, Example S156::US10806718, Example 156::US11026923, Example 156::US11491140, Example 156::US11634416, Example 156 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 31.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279125&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273448 378160707 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954976 CCOc1ncccc1-c1cc(CNc2cncc(OC)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-20(8-7-9-26-24)21-10-17(12-27-18-11-19(31-5)14-25-13-18)23-22(28-21)16(4)29-30(23)15(2)3/h7-11,13-15,27H,6,12H2,1-5H3 BXZMPJVMGAVKJS-UHFFFAOYSA-N 279126 N-[[5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-yl]methyl]-5-methoxy-pyridin-3-amine::US10034861, Example 157::US10512632, Example 157::US10766893, Example S157::US10806718, Example 157::US11026923, Example 157::US11491140, Example 157::US11634416, Example 157 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 34.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279126&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273449 378160708 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954979 CCOc1ncccc1-c1cc(CNc2ncn(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-6-30-20-16(8-7-9-22-20)17-10-15(11-23-21-24-12-28(5)27-21)19-18(25-17)14(4)26-29(19)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,23,27) XUAILHHYTLESDG-UHFFFAOYSA-N 279127 N-[[5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-yl]methyl]-1-methyl-1,2,4-triazol-3-amine::US10034861, Example 158::US10512632, Example 158::US10766893, Example S158::US10806718, Example 158::US11026923, Example 158::US11491140, Example 158::US11634416, Example 158 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 23.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279127&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273450 378160709 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954982 CCOc1ncccc1-c1cc(CCc2cncc(OC)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C25H29N5O2/c1-6-32-25-21(8-7-11-27-25)22-13-19(10-9-18-12-20(31-5)15-26-14-18)24-23(28-22)17(4)29-30(24)16(2)3/h7-8,11-16H,6,9-10H2,1-5H3 KRADQTILGMSJGT-UHFFFAOYSA-N 279128 5-(2-ethoxy-3-pyridyl)-1-isopropyl-7-[2-(5-methoxy-3-pyridyl)ethyl]-3-methyl-pyrazolo[4,3-b]pyridine::US10034861, Example 159::US10512632, Example 159::US10766893, Example S159::US10806718, Example 159::US11026923, Example 159::US11491140, Example 159::US11634416, Example 159 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 270 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279128&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273451 378160710 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954985 CCOc1ncccc1-c1cc(CCc2ncn(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H27N7O/c1-6-30-22-17(8-7-11-23-22)18-12-16(9-10-19-24-13-28(5)27-19)21-20(25-18)15(4)26-29(21)14(2)3/h7-8,11-14H,6,9-10H2,1-5H3 DQKKFAGODSQYOO-UHFFFAOYSA-N 279129 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-7-[2-(1-methyl-1,2,4-triazol-3-yl)ethyl]pyrazolo[4,3-b]pyridine::US10034861, Example 160::US10512632, Example 160::US10766893, Example S160::US10806718, Example 160::US11026923, Example 160::US11491140, Example 160::US11634416, Example 160 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 23.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279129&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273452 378160711 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954988 CCOc1ncccc1-c1cc(NCc2ncnn2C)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-6-30-21-15(8-7-9-22-21)16-10-17(23-11-18-24-12-25-28(18)5)20-19(26-16)14(4)27-29(20)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,23,26) DSJWNAKWTOCISO-UHFFFAOYSA-N 425070 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methyl-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10512632, Example 161::US10618913, Example S161::US10766893, Example S161::US10806718, Example 161::US11026923, Example 161::US11491140, Example 162::US11634416, Example 161 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 60.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=425070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=425070&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138536279 434150493 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954991 CCOc1ncccc1-c1cc(NCc2nncn2C)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-6-30-21-15(8-7-9-22-21)16-10-17(23-11-18-26-24-12-28(18)5)20-19(25-16)14(4)27-29(20)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,23,25) XEGYXYUUSUWLRL-UHFFFAOYSA-N 279131 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(4-methyl-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 162::US10512632, Example 162::US10766893, Example S162::US11026923, Example 162::US11634416, Example 162 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 100.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279131&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273453 378160712 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954994 CCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(nc(C)c2n1)C1COC1 InChI=1S/C21H24N8O2/c1-4-31-21-15(6-5-7-22-21)16-8-17(23-9-18-24-12-28(3)27-18)20-19(25-16)13(2)26-29(20)14-10-30-11-14/h5-8,12,14H,4,9-11H2,1-3H3,(H,23,25) KHCSAUOHEOUDEI-UHFFFAOYSA-N 279132 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]-1-(oxetan-3-yl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 163::US10512632, Example 163::US10618913, Example S163::US10766893, Example S163::US10806718, Example 163::US11026923, Example 163::US11491140, Example 163::US11634416, Example 163 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 120 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279132&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273457 378160713 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954997 CCOc1ncccc1-c1cc(SCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6OS/c1-6-29-22-17(8-7-9-23-22)18-10-19(30-13-16-11-24-27(5)12-16)21-20(25-18)15(4)26-28(21)14(2)3/h7-12,14H,6,13H2,1-5H3 KZXTWLBNMJOSPX-UHFFFAOYSA-N 462449 US10766893, Example S164 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 6.80 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462449 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462449&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273454 441293634 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 955000 CCOc1ncccc1-c1cc(NCc2cnn(c2)C(F)F)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H25F2N7O/c1-5-32-21-16(7-6-8-25-21)17-9-18(26-10-15-11-27-30(12-15)22(23)24)20-19(28-17)14(4)29-31(20)13(2)3/h6-9,11-13,22H,5,10H2,1-4H3,(H,26,28) QXWVDSKSPDSRJQ-UHFFFAOYSA-N 462450 US10766893, Example S165 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 73.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462450 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462450&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273458 441293635 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 955003 CCOc1ncccc1-c1cc(NCc2cc(CF)on2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H25FN6O2/c1-5-30-22-17(7-6-8-24-22)18-10-19(25-12-15-9-16(11-23)31-28-15)21-20(26-18)14(4)27-29(21)13(2)3/h6-10,13H,5,11-12H2,1-4H3,(H,25,26) XUHFADCPGYKQAR-UHFFFAOYSA-N 279135 5-(2-ethoxy-3-pyridyl)-N-[[5-(fluoromethyl)isoxazol-3-yl]methyl]-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::BDBM425076::US10034861, Example 166::US10512632, Example 166::US10766893, Example S166::US10806718, Example 166::US11026923, Example 166::US11491140, Example 166::US11634416, Example 166 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.10 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279135&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273459 378160716 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 955006 CCOc1ncccc1-c1cc(NCc2cc(CF)no2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H25FN6O2/c1-5-30-22-17(7-6-8-24-22)18-10-19(25-12-16-9-15(11-23)28-31-16)21-20(26-18)14(4)27-29(21)13(2)3/h6-10,13H,5,11-12H2,1-4H3,(H,25,26) VTULNMARMGUDCN-UHFFFAOYSA-N 279136 5-(2-ethoxy-3-pyridyl)-N-[[3-(fluoromethyl)isoxazol-5-yl]methyl]-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 167::US10766893, Example S167::US10806718, Example 167::US11026923, Example 167::US11491140, Example 167::US11634416, Example 167 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 11.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279136&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273460 378160717 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 955009 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1ncco1 InChI=1S/C18H21N7O/c1-11(2)25-17-14(20-8-13-9-21-24(4)10-13)7-15(18-19-5-6-26-18)22-16(17)12(3)23-25/h5-7,9-11H,8H2,1-4H3,(H,20,22) IMKYKBMLZRNQRQ-UHFFFAOYSA-N 279137 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-oxazol-2-yl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 168::US10512632, Example 168::US10618913, Example S168::US10766893, Example S168::US10806718, Example 168::US11026923, Example 168::US11491140, Example 168::US11634416, Example 168 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 14.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279137&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273461 378160718 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 955012 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1cnnn1C InChI=1S/C18H23N9/c1-11(2)27-18-15(19-7-13-8-21-25(4)10-13)6-14(16-9-20-24-26(16)5)22-17(18)12(3)23-27/h6,8-11H,7H2,1-5H3,(H,19,22) YPYKZBZKFWCVCN-UHFFFAOYSA-N 279138 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-(3-methyltriazol-4-yl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 169::US10512632, Example 169::US10618913, Example S169::US10766893, Example S169::US10806718, Example 169::US11026923, Example 169::US11491140, Example 169::US11634416, Example 169 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 610 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279138&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273462 378160719 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 955015 COc1ncccc1-c1cc(NCc2cccnc2C(F)(F)F)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H23F3N6O/c1-13(2)32-20-18(29-12-15-7-5-9-27-21(15)23(24,25)26)11-17(30-19(20)14(3)31-32)16-8-6-10-28-22(16)33-4/h5-11,13H,12H2,1-4H3,(H,29,30) GLFDPBHOMZCMEF-UHFFFAOYSA-N 279139 1-isopropyl-5-(2-methoxy-3-pyridyl)-3-methyl-N-[[2-(trifluoromethyl)-3-pyridyl]methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 170::US10512632, Example 170::US10766893, Example S170::US10806718, Example 170::US11026923, Example 170::US11491140, Example 170::US11634416, Example 170 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 42.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279139&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273463 378160720 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 955018 COc1ncccc1CNc1cc(nc2c(C)nn(C(C)C)c12)-c1ccc[nH]c1=O InChI=1S/C22H24N6O2/c1-13(2)28-20-18(25-12-15-7-5-10-24-22(15)30-4)11-17(26-19(20)14(3)27-28)16-8-6-9-23-21(16)29/h5-11,13H,12H2,1-4H3,(H,23,29)(H,25,26) YJCZMNIYQABZMT-UHFFFAOYSA-N 279140 3-[1-isopropyl-7-[(2-methoxy-3-pyridyl)methylamino]-3-methyl-pyrazolo[4,3-b]pyridin-5-yl]-1H-pyridin-2-one::US10034861, Example 171::US10512632, Example 171::US10766893, Example S171::US10806718, Example 171::US11026923, Example 171::US11491140, Example 171::US11634416, Example 171 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 290 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279140 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279140&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 136214892 378160721 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 955021 CCOc1ncccc1-c1cc(NCc2ccncc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(8-7-10-26-24)19-12-20(27-13-17-9-11-25-14-21(17)31-5)23-22(28-19)16(4)29-30(23)15(2)3/h7-12,14-15H,6,13H2,1-5H3,(H,27,28) ZDNREOIUOKDWKN-UHFFFAOYSA-N 425081 US10512632, Example 172::US10766893, Example S172::US10806718, Example 172::US11026923, Example 172::US11491140, Example 172::US11634416, Example 172 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 40.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=425081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=425081&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138535948 434150496 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 955024 COc1ncccc1-c1cc(NCc2cnc(C)s2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H24N6OS/c1-12(2)27-20-18(24-11-15-10-23-14(4)29-15)9-17(25-19(20)13(3)26-27)16-7-6-8-22-21(16)28-5/h6-10,12H,11H2,1-5H3,(H,24,25) SVOMGFJYTSFSPH-UHFFFAOYSA-N 279142 1-isopropyl-5-(2-methoxy-3-pyridyl)-3-methyl-N-[(2-methylthiazol-5-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 173::US10512632, Example 173::US10766893, Example S173::US11026923, Example 173::US11491140, Example 173::US11634416, Example 173 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 49.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279142&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273465 378160722 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954349 CCOc1ncccc1-c1cc(NCc2cccn3c(C)nnc23)c2n(nc(C)c2n1)C(C)C InChI=1S/C25H28N8O/c1-6-34-25-19(10-7-11-26-25)20-13-21(23-22(28-20)16(4)31-33(23)15(2)3)27-14-18-9-8-12-32-17(5)29-30-24(18)32/h7-13,15H,6,14H2,1-5H3,(H,27,28) UIVFRKVIYRJRGX-UHFFFAOYSA-N 462232 US10766893, Example 1a Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 3.00 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462232 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462232&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138692659 441293436 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954352 CCOc1ncccc1-c1cc(NCc2cccc3nsnc23)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H25N7OS/c1-5-32-24-17(9-7-11-25-24)19-12-20(23-21(27-19)15(4)28-31(23)14(2)3)26-13-16-8-6-10-18-22(16)30-33-29-18/h6-12,14H,5,13H2,1-4H3,(H,26,27) RJISSJINTRICQD-UHFFFAOYSA-N 462233 US10766893, Example 2a Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 53.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462233 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462233&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138692677 441293437 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954355 CCOc1ncccc1-c1cc(NCc2cccn3cnnc23)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H26N8O/c1-5-33-24-18(9-6-10-25-24)19-12-20(22-21(28-19)16(4)30-32(22)15(2)3)26-13-17-8-7-11-31-14-27-29-23(17)31/h6-12,14-15H,5,13H2,1-4H3,(H,26,28) CMXBMGHSZLGYSA-UHFFFAOYSA-N 462234 US10766893, Example 3a Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4.70 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462234 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462234&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138692695 441293438 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954358 CCOc1ncccc1-c1cc(NCc2cccn3ccnc23)c2n(nc(C)c2n1)C(C)C InChI=1S/C25H27N7O/c1-5-33-25-19(9-6-10-27-25)20-14-21(23-22(29-20)17(4)30-32(23)16(2)3)28-15-18-8-7-12-31-13-11-26-24(18)31/h6-14,16H,5,15H2,1-4H3,(H,28,29) LIETXPWXCFWTIC-UHFFFAOYSA-N 462235 US10766893, Example 4a Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 6.60 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462235&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138692765 441293439 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954361 CCOc1ncccc1-c1cc(NCc2cccn3nccc23)c2n(nc(C)c2n1)C(C)C InChI=1S/C25H27N7O/c1-5-33-25-19(9-6-11-26-25)20-14-21(24-23(29-20)17(4)30-32(24)16(2)3)27-15-18-8-7-13-31-22(18)10-12-28-31/h6-14,16H,5,15H2,1-4H3,(H,27,29) BNYZJWCUZPHDAQ-UHFFFAOYSA-N 462236 US10766893, Example 5a Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 53.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462236&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138692678 441293440 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954364 CCOc1ncccc1-c1cc(NCc2cccc3ncnn23)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H26N8O/c1-5-33-24-18(9-7-11-25-24)19-12-20(23-22(29-19)16(4)30-31(23)15(2)3)26-13-17-8-6-10-21-27-14-28-32(17)21/h6-12,14-15H,5,13H2,1-4H3,(H,26,29) UJDVXLMRTWCGAG-UHFFFAOYSA-N 462237 US10766893, Example 6a Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 18.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462237 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462237&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138692757 441293441 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954367 CCOc1ncccc1-c1cc(NCc2cccc3nc(C)nn23)c2n(nc(C)c2n1)C(C)C InChI=1S/C25H28N8O/c1-6-34-25-19(10-8-12-26-25)20-13-21(24-23(29-20)16(4)30-32(24)15(2)3)27-14-18-9-7-11-22-28-17(5)31-33(18)22/h7-13,15H,6,14H2,1-5H3,(H,27,29) JCJMWMYJXUGFNN-UHFFFAOYSA-N 462238 US10766893, Example 7a Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 11.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462238 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462238&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138692738 441293442 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954370 CCOc1ncccc1-c1cc(NCc2cccn3cncc23)c2n(nc(C)c2n1)C(C)C InChI=1S/C25H27N7O/c1-5-33-25-19(9-6-10-27-25)20-12-21(24-23(29-20)17(4)30-32(24)16(2)3)28-13-18-8-7-11-31-15-26-14-22(18)31/h6-12,14-16H,5,13H2,1-4H3,(H,28,29) KCQMAJIZKUXJDU-UHFFFAOYSA-N 462239 US10766893, Example 8a Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 3.20 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462239&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138692770 441293443 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954373 CCOc1ncccc1-c1cc(NCc2cccc3ncoc23)c2n(nc(C)c2n1)C(C)C InChI=1S/C25H26N6O2/c1-5-32-25-18(9-7-11-26-25)20-12-21(23-22(29-20)16(4)30-31(23)15(2)3)27-13-17-8-6-10-19-24(17)33-14-28-19/h6-12,14-15H,5,13H2,1-4H3,(H,27,29) RMUSMCFAULZFDZ-UHFFFAOYSA-N 462240 US10766893, Example 9a Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 45.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462240&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138692724 441293444 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954376 CCOc1ncccc1-c1cc(NCc2cccc3ocnc23)c2n(nc(C)c2n1)C(C)C InChI=1S/C25H26N6O2/c1-5-32-25-18(9-7-11-26-25)19-12-20(24-22(29-19)16(4)30-31(24)15(2)3)27-13-17-8-6-10-21-23(17)28-14-33-21/h6-12,14-15H,5,13H2,1-4H3,(H,27,29) IVPWVFJBRNZRTL-UHFFFAOYSA-N 462241 US10766893, Example 10a Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 14.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462241 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462241&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138692748 441293445 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954379 CCOc1ncccc1-c1cc(NCc2cccc3oc(C)nc23)c2n(nc(C)c2n1)C(C)C InChI=1S/C26H28N6O2/c1-6-33-26-19(10-8-12-27-26)20-13-21(25-23(30-20)16(4)31-32(25)15(2)3)28-14-18-9-7-11-22-24(18)29-17(5)34-22/h7-13,15H,6,14H2,1-5H3,(H,28,30) USWMJZZZYCJYJT-UHFFFAOYSA-N 462242 US10766893, Example 11a Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 18.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462242&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138692691 441293446 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 955027 COc1ncccc1CNc1cc(nc2c(C)nn(C(C)C)c12)-c1cccnc1OC1CC1 InChI=1S/C25H28N6O2/c1-15(2)31-23-21(28-14-17-7-5-11-26-24(17)32-4)13-20(29-22(23)16(3)30-31)19-8-6-12-27-25(19)33-18-9-10-18/h5-8,11-13,15,18H,9-10,14H2,1-4H3,(H,28,29) QLFKDVQWAWXRKU-UHFFFAOYSA-N 279143 5-(2-cyclopropoxypyridin-3-yl)-1-isopropyl-N-((2-methoxypyridin-3-yl)methyl)-3-methyl-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 174::US10512632, Example 174::US10766893, Example S174::US10806718, Example 174::US11026923, Example 174::US11491140, Example 174::US11634416, Example 174 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 18.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279143 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279143&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273466 378160723 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 955030 COc1ncccc1CNc1cc(nc2c(C)nn(C(C)C)c12)-c1ccnn1C InChI=1S/C21H25N7O/c1-13(2)28-20-17(23-12-15-7-6-9-22-21(15)29-5)11-16(18-8-10-24-27(18)4)25-19(20)14(3)26-28/h6-11,13H,12H2,1-5H3,(H,23,25) CROUXODBTXNMIZ-UHFFFAOYSA-N 279144 1-isopropyl-N-((2-methoxypyridin-3-yl)methyl)-3-methyl-5-(1-methyl-1H-pyrazol-5-yl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 175::US10512632, Example 175::US10766893, Example S175::US10806718, Example 175::US11026923, Example 175::US11491140, Example 175::US11634416, Example 175 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 83.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279144&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273467 378160724 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 955033 CCOc1ncccc1-c1cc(NCc2ncc(OC)cn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O2/c1-6-32-23-17(8-7-9-24-23)18-10-19(25-13-20-26-11-16(31-5)12-27-20)22-21(28-18)15(4)29-30(22)14(2)3/h7-12,14H,6,13H2,1-5H3,(H,25,28) NLZDQEYNQWGPGP-UHFFFAOYSA-N 279145 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(5-methoxypyrimidin-2-yl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 176::US10512632, Example 176::US10766893, Example S176::US10806718, Example 176::US11026923, Example 176::US11491140, Example 176::US11634416, Example 176 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 81.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279145&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273468 378160725 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 955036 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1ccc[nH]c1=O InChI=1S/C20H23N7O/c1-12(2)27-19-17(22-9-14-10-23-26(4)11-14)8-16(24-18(19)13(3)25-27)15-6-5-7-21-20(15)28/h5-8,10-12H,9H2,1-4H3,(H,21,28)(H,22,24) ZZXWQIDOSVIHIM-UHFFFAOYSA-N 279146 3-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]-1H-pyridin-2-one::US10034861, Example 177::US10512632, Example 177::US10766893, Example S177::US10806718, Example 177::US11026923, Example 177::US11491140, Example 177::US11634416, Example 177 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 130 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279146&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 136214893 378160726 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 955039 CCOc1ncccc1-c1cc(NCc2cccnc2C(F)F)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H26F2N6O/c1-5-33-24-17(9-7-11-28-24)18-12-19(22-20(30-18)15(4)31-32(22)14(2)3)29-13-16-8-6-10-27-21(16)23(25)26/h6-12,14,23H,5,13H2,1-4H3,(H,29,30) IRSHUSVLDQPATB-UHFFFAOYSA-N 279147 N-[[2-(difluoromethyl)-3-pyridyl]methyl]-5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 178::US10512632, Example 178::US10766893, Example S178::US10806718, Example 178::US11026923, Example 178::US11491140, Example 178::US11634416, Example 178 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 31.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279147&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273469 378160727 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 955042 CCOc1ncccc1-c1cc(NCc2cc(OC)ncn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O2/c1-6-32-23-17(8-7-9-24-23)18-11-19(25-12-16-10-20(31-5)27-13-26-16)22-21(28-18)15(4)29-30(22)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,25,28) RTCQCKBUFIYEDZ-UHFFFAOYSA-N 279148 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(6-methoxypyrimidin-4-yl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 179::US10512632, Example 179::US10766893, Example S179::US10806718, Example 179::US11026923, Example 179::US11491140, Example 179::US11634416, Example 179 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.80 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279148&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273471 378160728 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 955045 COc1ncccc1CNc1cc(nc2c(C)nn(C(C)C)c12)-c1cccnc1OC InChI=1S/C23H26N6O2/c1-14(2)29-21-19(26-13-16-8-6-10-24-22(16)30-4)12-18(27-20(21)15(3)28-29)17-9-7-11-25-23(17)31-5/h6-12,14H,13H2,1-5H3,(H,26,27) YPNDBZHHIYJRNN-UHFFFAOYSA-N 279064 1-isopropyl-5-(2-methoxy-3-pyridyl)-N-[(2-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 95::US10512632, Example 95::US10766893, Example S95::US10806718, Example 95::US11026923, Example 95::US11491140, Example 95::US11634416, Example 95 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 27.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279064 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279064&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273392 378160652 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 955048 CCOc1ncccc1-c1cc(NCc2cccnc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(10-8-12-26-24)19-13-20(27-14-17-9-7-11-25-23(17)31-5)22-21(28-19)16(4)29-30(22)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) LOZUTDKVJLMDTB-UHFFFAOYSA-N 279055 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 172::US10034861, Example 180::US10034861, Example 181::US10034861, Example 182::US10034861, Example 86::US10512632, Example 86::US10766893, Example S86::US10806718, Example 182::US11026923, Example 182::US11491140, Example 86::US11634416, Example 86 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 31.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279055&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273386 378160643 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 955051 CCOc1ncccc1-c1cc(NCc2cccnc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(10-8-12-26-24)19-13-20(27-14-17-9-7-11-25-23(17)31-5)22-21(28-19)16(4)29-30(22)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) LOZUTDKVJLMDTB-UHFFFAOYSA-N 279055 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 172::US10034861, Example 180::US10034861, Example 181::US10034861, Example 182::US10034861, Example 86::US10512632, Example 86::US10766893, Example S86::US10806718, Example 182::US11026923, Example 182::US11491140, Example 86::US11634416, Example 86 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 24.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279055&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273386 378160643 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 955054 COc1ncccc1CNc1cc(nc2c(C)nn(C(C)C)c12)-c1cccnc1C(F)(F)F InChI=1S/C23H23F3N6O/c1-13(2)32-20-18(29-12-15-7-5-10-28-22(15)33-4)11-17(30-19(20)14(3)31-32)16-8-6-9-27-21(16)23(24,25)26/h5-11,13H,12H2,1-4H3,(H,29,30) AAAZUNCZBZHDPM-UHFFFAOYSA-N 279152 1-isopropyl-N-((2-methoxypyridin-3-yl)methyl)-3-methyl-5-(2-(trifluoromethyl)pyridin-3-yl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 183::US10512632, Example 183::US10766893, Example S183::US10806718, Example 183::US11634416, Example 183 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 290 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279152&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273472 378160729 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 955057 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C(F)F)c2n1)C(C)C InChI=1S/C22H25F2N7O/c1-5-32-22-15(7-6-8-25-22)16-9-17(26-10-14-11-27-30(4)12-14)20-18(28-16)19(21(23)24)29-31(20)13(2)3/h6-9,11-13,21H,5,10H2,1-4H3,(H,26,28) YFAHCXPQQYYPCW-UHFFFAOYSA-N 279153 3-(difluoromethyl)-5-(2-ethoxypyridin-3-yl)-1-isopropyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 184::US10512632, Example 184::US10618913, Example S184::US10766893, Example S184::US10806718, Example 184::US11491140, Example 184::US11634416, Example 184 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 13.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279153&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273473 378160730 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 955060 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-n1cncn1 InChI=1S/C17H21N9/c1-11(2)26-17-14(19-6-13-7-20-24(4)8-13)5-15(25-10-18-9-21-25)22-16(17)12(3)23-26/h5,7-11H,6H2,1-4H3,(H,19,22) VELNJFTUSCXPKE-UHFFFAOYSA-N 279154 1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-5-(1H-1,2,4-triazol-1-yl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 185::US10512632, Example 185::US10766893, Example S185::US10806718, Example 185::US11026923, Example 185::US11491140, Example 185::US11634416, Example 185 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 100.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279154&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273474 378160731 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 955063 CC(C)n1nc(C)c2nc(cc(NCc3ncn(C)n3)c12)-c1ccc[nH]c1=O InChI=1S/C19H22N8O/c1-11(2)27-18-15(21-9-16-22-10-26(4)25-16)8-14(23-17(18)12(3)24-27)13-6-5-7-20-19(13)28/h5-8,10-11H,9H2,1-4H3,(H,20,28)(H,21,23) LRKYMHYCQWOGDT-UHFFFAOYSA-N 279155 3-[1-isopropyl-3-methyl-7-[(1-methyl-1,2,4-triazol-3-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]-1H-pyridin-2-one::US10034861, Example 186::US10512632, Example 186::US10766893, Example S186::US10806718, Example 186::US11026923, Example 186::US11491140, Example 186::US11634416, Example 186 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 64.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279155&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 136214894 378160732 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 955066 CC(C)n1nc(C)c2nc(cc(NCc3cc[nH]n3)c12)-c1ccc[nH]c1=O InChI=1S/C19H21N7O/c1-11(2)26-18-16(21-10-13-6-8-22-24-13)9-15(23-17(18)12(3)25-26)14-5-4-7-20-19(14)27/h4-9,11H,10H2,1-3H3,(H,20,27)(H,21,23)(H,22,24) FWAXXZSYYYRIBS-UHFFFAOYSA-N 279156 3-[1-isopropyl-3-methyl-7-(1H-pyrazol-3-ylmethylamino)pyrazolo[4,3-b]pyridin-5-yl]-1H-pyridin-2-one::US10034861, Example 187::US10512632, Example 187::US10766893, Example S187::US10806718, Example 187::US11026923, Example 187::US11491140, Example 187::US11634416, Example 187 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 140 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279156&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 136214895 378160733 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 955069 COc1ncccc1CNc1cc(nc2c(C)nn(C(C)C)c12)-c1cccnc1OC(F)F InChI=1S/C23H24F2N6O2/c1-13(2)31-20-18(28-12-15-7-5-9-26-21(15)32-4)11-17(29-19(20)14(3)30-31)16-8-6-10-27-22(16)33-23(24)25/h5-11,13,23H,12H2,1-4H3,(H,28,29) HFYVDFFGOVRRIK-UHFFFAOYSA-N 279157 5-[2-(difluoromethoxy)-3-pyridyl]-1-isopropyl-N-[(2-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 188::US10512632, Example 188::US10766893, Example S188::US11026923, Example 188::US11491140, Example 188::US11634416, Example 188 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 61.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279157&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273478 378160734 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954382 CCOc1ncccc1-c1cc(NCc2ccc3oc(C)nc3c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C26H28N6O2/c1-6-33-26-19(8-7-11-27-26)20-13-22(25-24(30-20)16(4)31-32(25)15(2)3)28-14-18-9-10-23-21(12-18)29-17(5)34-23/h7-13,15H,6,14H2,1-5H3,(H,28,30) RPWGRSSYQVYHBU-UHFFFAOYSA-N 462243 US10766893, Example 12a Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.70 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462243 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462243&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138692700 441293447 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954385 CCOc1nnccc1-c1cc(NCc2cccc3ocnc23)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H25N7O2/c1-5-32-24-17(9-10-27-29-24)18-11-19(23-21(28-18)15(4)30-31(23)14(2)3)25-12-16-7-6-8-20-22(16)26-13-33-20/h6-11,13-14H,5,12H2,1-4H3,(H,25,28) QDTGSDIZPRKYIY-UHFFFAOYSA-N 462244 US10766893, Example 13a Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 39.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462244&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138692682 441293448 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954388 CCOc1nnccc1-c1cc(NCc2cccc3oc(C)nc23)c2n(nc(C)c2n1)C(C)C InChI=1S/C25H27N7O2/c1-6-33-25-18(10-11-27-30-25)19-12-20(24-22(29-19)15(4)31-32(24)14(2)3)26-13-17-8-7-9-21-23(17)28-16(5)34-21/h7-12,14H,6,13H2,1-5H3,(H,26,29) QLVIOCVYPVUMNY-UHFFFAOYSA-N 462245 US10766893, Example 14a Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 9.30 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462245 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462245&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138692690 441293449 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954391 CCOc1ncccc1-c1cc(NCc2nccc3nncn23)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H25N9O/c1-5-33-23-16(7-6-9-25-23)17-11-18(22-21(28-17)15(4)30-32(22)14(2)3)26-12-20-24-10-8-19-29-27-13-31(19)20/h6-11,13-14H,5,12H2,1-4H3,(H,26,28) KOOPKPXDGQEPLM-UHFFFAOYSA-N 462246 US10766893, Example 15a Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 30.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462246 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462246&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138692686 441293450 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954394 CCOc1ncccc1-c1cc(NCc2nccc3nccn23)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H26N8O/c1-5-33-24-17(7-6-9-27-24)18-13-19(23-22(29-18)16(4)30-32(23)15(2)3)28-14-21-25-10-8-20-26-11-12-31(20)21/h6-13,15H,5,14H2,1-4H3,(H,28,29) YKYCEIQQBDUXHL-UHFFFAOYSA-N 462247 US10766893, Example 16a Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 35.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462247 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462247&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138692772 441293451 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954397 CCOc1nnccc1-c1cc(NCc2ncccn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H24N8O/c1-5-30-21-15(7-10-25-27-21)16-11-17(24-12-18-22-8-6-9-23-18)20-19(26-16)14(4)28-29(20)13(2)3/h6-11,13H,5,12H2,1-4H3,(H,24,26) WTKXUHYZWCXYJV-UHFFFAOYSA-N 462248 US10766893, Example 1b Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 11.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462248 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462248&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138692660 441293452 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954400 COc1nnccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C20H24N8O/c1-12(2)28-19-17(21-9-14-10-23-27(4)11-14)8-16(24-18(19)13(3)26-28)15-6-7-22-25-20(15)29-5/h6-8,10-12H,9H2,1-5H3,(H,21,24) ZPDPMYSSSZGQNO-UHFFFAOYSA-N 462249 US10766893, Example 2b Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 45.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462249 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462249&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138692726 441293453 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954403 CCOc1nnccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-6-30-21-16(7-8-23-26-21)17-9-18(22-10-15-11-24-28(5)12-15)20-19(25-17)14(4)27-29(20)13(2)3/h7-9,11-13H,6,10H2,1-5H3,(H,22,25) SNBCJPFRPGAYQC-UHFFFAOYSA-N 462250 US10766893, Example 3b Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 6.10 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462250 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462250&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138692688 441293454 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954406 CCCOc1nnccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H28N8O/c1-6-9-31-22-17(7-8-24-27-22)18-10-19(23-11-16-12-25-29(5)13-16)21-20(26-18)15(4)28-30(21)14(2)3/h7-8,10,12-14H,6,9,11H2,1-5H3,(H,23,26) RJECUSNDCHWSNO-UHFFFAOYSA-N 462251 US10766893, Example 4b Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 3.20 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462251 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462251&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138692769 441293455 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954409 CCOc1nnccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C22H28N8O/c1-6-14(3)30-21-19(23-11-16-12-25-29(5)13-16)10-18(26-20(21)15(4)28-30)17-8-9-24-27-22(17)31-7-2/h8-10,12-14H,6-7,11H2,1-5H3,(H,23,26) UXVRWXLBBBUCGV-UHFFFAOYSA-N 462252 US10766893, Example 5b::US10766893, Example 6b Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 25.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462252 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462252&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138692670 441293456 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954412 CCOc1nnccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C22H28N8O/c1-6-14(3)30-21-19(23-11-16-12-25-29(5)13-16)10-18(26-20(21)15(4)28-30)17-8-9-24-27-22(17)31-7-2/h8-10,12-14H,6-7,11H2,1-5H3,(H,23,26) UXVRWXLBBBUCGV-UHFFFAOYSA-N 462252 US10766893, Example 5b::US10766893, Example 6b Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.90 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462252 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462252&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138692670 441293456 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954415 CCOc1nnccc1-c1cc(NCc2cccnc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O2/c1-6-32-23-17(9-11-26-28-23)18-12-19(25-13-16-8-7-10-24-22(16)31-5)21-20(27-18)15(4)29-30(21)14(2)3/h7-12,14H,6,13H2,1-5H3,(H,25,27) MDKARWWQHZIIKR-UHFFFAOYSA-N 462254 US10766893, Example 7b Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 11.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462254 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462254&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138692683 441293457 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954418 CCOc1nnccc1-c1cc(NCc2nnc(C)o2)c2n(nc(C)c2n1)C(C)C InChI=1S/C20H24N8O2/c1-6-29-20-14(7-8-22-26-20)15-9-16(21-10-17-25-24-13(5)30-17)19-18(23-15)12(4)27-28(19)11(2)3/h7-9,11H,6,10H2,1-5H3,(H,21,23) OMNGIUDHDBCZAD-UHFFFAOYSA-N 462255 US10766893, Example 8b Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 97.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462255 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462255&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138692745 441293458 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954421 CCOc1nnccc1-c1cc(NCc2ccn(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-6-30-21-16(7-9-23-25-21)17-11-18(22-12-15-8-10-28(5)27-15)20-19(24-17)14(4)26-29(20)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,22,24) DXLJOZZMNNLQIG-UHFFFAOYSA-N 462256 US10766893, Example 9b Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 5.20 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462256 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462256&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138692657 441293459 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 955072 CCOc1ncccc1-c1cc(NCc2nccc(OC)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O2/c1-6-32-23-16(8-7-10-25-23)17-12-18(26-13-19-24-11-9-20(28-19)31-5)22-21(27-17)15(4)29-30(22)14(2)3/h7-12,14H,6,13H2,1-5H3,(H,26,27) ZRCQWXKCYCHOGM-UHFFFAOYSA-N 279158 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(4-methoxypyrimidin-2-yl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 189::US10512632, Example 189::US10766893, Example S189::US10806718, Example 189::US11026923, Example 189::US11491140, Example 189::US11634416, Example 189 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 3.90 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279158&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273477 378160735 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 955075 CCOc1ncccc1-c1cc(NCc2cncnc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O2/c1-6-32-23-17(8-7-9-25-23)18-10-19(26-12-16-11-24-13-27-22(16)31-5)21-20(28-18)15(4)29-30(21)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,26,28) FQSCOMBJMAVYMG-UHFFFAOYSA-N 279159 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(4-methoxypyrimidin-5-yl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 190::US10512632, Example 190::US10766893, Example S190::US10806718, Example 190::US11026923, Example 190::US11491140, Example 190::US11634416, Example 190 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 74.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279159&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273480 378160736 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 955078 CCOc1ncccc1CNc1cc(nc2c(C)nn(C(C)C)c12)-c1cccnc1OCC InChI=1S/C25H30N6O2/c1-6-32-24-18(10-8-12-26-24)15-28-21-14-20(19-11-9-13-27-25(19)33-7-2)29-22-17(5)30-31(16(3)4)23(21)22/h8-14,16H,6-7,15H2,1-5H3,(H,28,29) RPFGIRQWMRKNBU-UHFFFAOYSA-N 279160 5-(2-ethoxy-3-pyridyl)-N-[(2-ethoxy-3-pyridyl)methyl]-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 191::US10512632, Example 191::US10766893, Example S191::US10806718, Example 191::US11026923, Example 191::US11491140, Example 191::US11634416, Example 191 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 160 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279160&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273479 378160737 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 955081 COc1ccc(CNc2cc(nc3c(C)nn(C(C)C)c23)-c2cccnc2N(C)C)cc1 InChI=1S/C25H30N6O/c1-16(2)31-24-22(27-15-18-9-11-19(32-6)12-10-18)14-21(28-23(24)17(3)29-31)20-8-7-13-26-25(20)30(4)5/h7-14,16H,15H2,1-6H3,(H,27,28) RMYFPLHNAGFJMC-UHFFFAOYSA-N 279161 5-[2-(dimethylamino)-3-pyridyl]-1-isopropyl-N-[(4-methoxyphenyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 192::US10512632, Example 192::US10766893, Example S192::US10806718, Example 192::US11026923, Example 192::US11491140, Example 192::US11634416, Example 192 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 630 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279161&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273481 378160738 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 955084 CC(C)n1nc(C)c2nc(cc(NCc3cccnc3C(F)(F)F)c12)-c1ccc[nH]c1=O InChI=1S/C22H21F3N6O/c1-12(2)31-19-17(28-11-14-6-4-8-26-20(14)22(23,24)25)10-16(29-18(19)13(3)30-31)15-7-5-9-27-21(15)32/h4-10,12H,11H2,1-3H3,(H,27,32)(H,28,29) CEASKHHYUJNGEA-UHFFFAOYSA-N 279162 3-[1-isopropyl-3-methyl-7-[[2-(trifluoromethyl)-3-pyridyl]methylamino]pyrazolo[4,3-b]pyridin-5-yl]-1H-pyridin-2-one::US10034861, Example 193::US10512632, Example 193::US10766893, Example S193::US10806718, Example 193::US11491140, Example 193::US11634416, Example 193 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 320 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279162&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 136214896 378160739 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 955087 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1conc1C InChI=1S/C19H23N7O/c1-11(2)26-19-17(20-7-14-8-21-25(5)9-14)6-16(15-10-27-24-12(15)3)22-18(19)13(4)23-26/h6,8-11H,7H2,1-5H3,(H,20,22) MTWLSLCQXJXQNM-UHFFFAOYSA-N 279163 1-isopropyl-3-methyl-5-(3-methylisoxazol-4-yl)-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 194::US10512632, Example 194::US10766893, Example S194::US10806718, Example 194::US11491140, Example 194::US11634416, Example 194 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 95.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279163&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273485 378160740 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 955090 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1ncnn1C InChI=1S/C18H23N9/c1-11(2)27-17-14(19-7-13-8-21-25(4)9-13)6-15(18-20-10-22-26(18)5)23-16(17)12(3)24-27/h6,8-11H,7H2,1-5H3,(H,19,23) KYLSIDIKSXHHCI-UHFFFAOYSA-N 279164 1-isopropyl-3-methyl-5-(1-methyl-1H-1,2,4-triazol-5-yl)-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 195::US10512632, Example 195::US10618913, Example S195::US10766893, Example S195::US10806718, Example 195::US11026923, Example 195::US11634416, Example 195 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 420 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279164&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273486 378160741 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 955093 CCCOc1ncccc1-c1cc(NCc2cn[nH]c2)c2n(CC)nc(C)c2n1 InChI=1S/C21H25N7O/c1-4-9-29-21-16(7-6-8-22-21)17-10-18(23-11-15-12-24-25-13-15)20-19(26-17)14(3)27-28(20)5-2/h6-8,10,12-13H,4-5,9,11H2,1-3H3,(H,23,26)(H,24,25) YBSFEKXKZHHHNB-UHFFFAOYSA-N 462481 US10766893, Example S196 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 18.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462481 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462481&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 155903621 441293663 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 955096 CCOc1ncccc1-c1cc(NCc2cccnc2OC)c2n(nc(C)c2n1)C1COC1 InChI=1S/C24H26N6O3/c1-4-33-24-18(8-6-10-26-24)19-11-20(27-12-16-7-5-9-25-23(16)31-3)22-21(28-19)15(2)29-30(22)17-13-32-14-17/h5-11,17H,4,12-14H2,1-3H3,(H,27,28) GRFJYHDUOKDAKO-UHFFFAOYSA-N 279166 5-(2-ethoxy-3-pyridyl)-N-[(2-methoxy-3-pyridyl)methyl]-3-methyl-1-(oxetan-3-yl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 197::US10512632, Example 197::US10618913, Example S197::US10766893, Example S197::US10806718, Example 197::US11491140, Example 197::US11634416, Example 197 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 190 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279166&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273484 378160743 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 955099 CCN(C)c1ncccc1-c1cc(NCc2ccc(OC)cc2)c2n(nc(C)c2n1)C(C)C InChI=1S/C26H32N6O/c1-7-31(5)26-21(9-8-14-27-26)22-15-23(28-16-19-10-12-20(33-6)13-11-19)25-24(29-22)18(4)30-32(25)17(2)3/h8-15,17H,7,16H2,1-6H3,(H,28,29) YNHQWVLFISTQIU-UHFFFAOYSA-N 279167 5-(2-(ethyl(methyl)amino)pyridin-3-yl)-1-isopropyl-N-(4-methoxybenzyl)-3-methyl-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 198::US10512632, Example 198::US10766893, Example S198::US10806718, Example 198::US11026923, Example 198::US11491140, Example 198::US11634416, Example 198 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1100 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279167 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279167&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273483 378160744 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 955102 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(CF)c2n1)C(C)C InChI=1S/C22H26FN7O/c1-5-31-22-16(7-6-8-24-22)17-9-18(25-11-15-12-26-29(4)13-15)21-20(27-17)19(10-23)28-30(21)14(2)3/h6-9,12-14H,5,10-11H2,1-4H3,(H,25,27) CRFWOMGBISLKHY-UHFFFAOYSA-N 279168 5-(2-ethoxypyridin-3-yl)-3-(fluoromethyl)-1-isopropyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 199::US10512632, Example 199::US10618913, Example S199::US10766893, Example S199::US10806718, Example 199::US11026923, Example 199::US11491140, Example 199::US11634416, Example 199 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 7.40 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279168&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273487 378160745 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 955105 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1ocnc1C InChI=1S/C19H23N7O/c1-11(2)26-18-15(20-7-14-8-22-25(5)9-14)6-16(19-13(4)21-10-27-19)23-17(18)12(3)24-26/h6,8-11H,7H2,1-5H3,(H,20,23) JVGYDVFOXCBHRN-UHFFFAOYSA-N 279169 1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-5-(4-methyloxazol-5-yl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 200::US10512632, Example 200::US10618913, Example S200::US10766893, Example S200::US10806718, Example 200::US11026923, Example 200::US11491140, Example 200::US11634416, Example 200 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 98.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279169&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273489 378160746 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 955108 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1cccnc1N(C)C InChI=1S/C22H28N8/c1-14(2)30-21-19(24-11-16-12-25-29(6)13-16)10-18(26-20(21)15(3)27-30)17-8-7-9-23-22(17)28(4)5/h7-10,12-14H,11H2,1-6H3,(H,24,26) JWSSTJTVRAZILB-UHFFFAOYSA-N 279170 5-[2-(dimethylamino)-3-pyridyl]-1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 201::US10512632, Example 201::US10766893, Example S201::US10806718, Example 201::US11026923, Example 201::US11491140, Example 201::US11634416, Example 201 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2100 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279170&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273490 378160747 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 955111 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1nc(C)co1 InChI=1S/C19H23N7O/c1-11(2)26-18-15(20-7-14-8-21-25(5)9-14)6-16(19-22-12(3)10-27-19)23-17(18)13(4)24-26/h6,8-11H,7H2,1-5H3,(H,20,23) GNUZZRWHGHQDMA-UHFFFAOYSA-N 279171 1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-5-(4-methyloxazol-2-yl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 202::US10512632, Example 202::US10766893, Example S202::US10806718, Example 202::US11634416, Example 202 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 92.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279171&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273491 378160748 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954424 CCOc1nnccc1-c1cc(NCc2ncc(F)cn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H23FN8O/c1-5-31-21-15(6-7-26-28-21)16-8-17(23-11-18-24-9-14(22)10-25-18)20-19(27-16)13(4)29-30(20)12(2)3/h6-10,12H,5,11H2,1-4H3,(H,23,27) AIKXKABMMRXBQU-UHFFFAOYSA-N 462257 US10766893, Example 10b Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 21.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462257 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462257&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138692741 441293460 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954427 CCOc1nnccc1-c1cc(NCc2nccc(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N8O/c1-6-31-22-16(8-10-25-28-22)17-11-18(24-12-19-23-9-7-14(4)26-19)21-20(27-17)15(5)29-30(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,24,27) MNQHDMXASPMHFE-UHFFFAOYSA-N 462258 US10766893, Example 11b Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 38.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462258 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462258&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138692768 441293461 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954430 CCOc1cnccc1-c1cc(NCc2cccc(F)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H25FN6O/c1-5-31-20-13-25-10-9-17(20)18-11-19(26-12-16-7-6-8-21(24)27-16)23-22(28-18)15(4)29-30(23)14(2)3/h6-11,13-14H,5,12H2,1-4H3,(H,26,28) CDWNSXIRMXQPBS-UHFFFAOYSA-N 462259 US10766893, Example 12b Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 22.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462259 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462259&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138692736 441293462 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954433 CCOc1cnccc1-c1cc(NCc2cc[nH]n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H25N7O/c1-5-29-19-12-22-8-7-16(19)17-10-18(23-11-15-6-9-24-26-15)21-20(25-17)14(4)27-28(21)13(2)3/h6-10,12-13H,5,11H2,1-4H3,(H,23,25)(H,24,26) AXEQFCFNPOGNCH-UHFFFAOYSA-N 462260 US10766893, Example 13b Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 24.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462260 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462260&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138692673 441293463 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954436 CCOc1nnccc1-c1cc(NCc2ccccn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H25N7O/c1-5-30-22-17(9-11-25-27-22)18-12-19(24-13-16-8-6-7-10-23-16)21-20(26-18)15(4)28-29(21)14(2)3/h6-12,14H,5,13H2,1-4H3,(H,24,26) YORZDHGTKSYMLN-UHFFFAOYSA-N 462261 US10766893, Example 14b Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 12.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462261 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462261&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138692753 441293464 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954439 CCOc1cnccc1-c1cc(NCc2ccccn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H26N6O/c1-5-30-21-14-24-11-9-18(21)19-12-20(26-13-17-8-6-7-10-25-17)23-22(27-19)16(4)28-29(23)15(2)3/h6-12,14-15H,5,13H2,1-4H3,(H,26,27) JWCLZUXPDRRRJM-UHFFFAOYSA-N 462262 US10766893, Example 15b Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 17.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462262 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462262&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138692675 441293465 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954442 CCOc1nnccc1-c1cc(NCc2cccnc2F)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H24FN7O/c1-5-31-22-16(8-10-26-28-22)17-11-18(25-12-15-7-6-9-24-21(15)23)20-19(27-17)14(4)29-30(20)13(2)3/h6-11,13H,5,12H2,1-4H3,(H,25,27) POVOCAKFKAXGDL-UHFFFAOYSA-N 462263 US10766893, Example 16b Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 18.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462263&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138692685 441293466 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954445 CCOc1cnccc1-c1cc(NCc2cccnc2F)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H25FN6O/c1-5-31-20-13-25-10-8-17(20)18-11-19(27-12-16-7-6-9-26-23(16)24)22-21(28-18)15(4)29-30(22)14(2)3/h6-11,13-14H,5,12H2,1-4H3,(H,27,28) YGFHMMKTVSGDPM-UHFFFAOYSA-N 462264 US10766893, Example 17b Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 20.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462264&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138692710 441293467 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954448 CCOc1nnccc1-c1cc(NCc2ncn(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C20H25N9O/c1-6-30-20-14(7-8-23-25-20)15-9-16(21-10-17-22-11-28(5)27-17)19-18(24-15)13(4)26-29(19)12(2)3/h7-9,11-12H,6,10H2,1-5H3,(H,21,24) HUUFBDYGPGJNNP-UHFFFAOYSA-N 462265 US10766893, Example 18b Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 3.60 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462265 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462265&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138692721 441293468 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954451 CCOc1cnccc1-c1cc(NCc2ncn(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-6-30-18-10-22-8-7-15(18)16-9-17(23-11-19-24-12-28(5)27-19)21-20(25-16)14(4)26-29(21)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,23,25) YXAHNICDXLENPY-UHFFFAOYSA-N 462266 US10766893, Example 19b Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 11.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462266&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138692777 441293469 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954454 CCOc1nnccc1-c1cc(NCc2cnc(C)s2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H25N7OS/c1-6-29-21-16(7-8-24-26-21)17-9-18(23-11-15-10-22-14(5)30-15)20-19(25-17)13(4)27-28(20)12(2)3/h7-10,12H,6,11H2,1-5H3,(H,23,25) BDGRHRZSPSHSPW-UHFFFAOYSA-N 462267 US10766893, Example 20b Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 5.70 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462267 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462267&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138692674 441293470 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954457 CCOc1cnccc1-c1cc(NCc2cnc(C)s2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6OS/c1-6-29-20-12-23-8-7-17(20)18-9-19(25-11-16-10-24-15(5)30-16)22-21(26-18)14(4)27-28(22)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,25,26) FMYUWFPXXXSXMP-UHFFFAOYSA-N 462268 US10766893, Example 21b Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 5.60 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462268 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462268&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138692667 441293471 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954460 CCOc1nnccc1-c1cc(NCc2cc(C)[nH]n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-6-30-21-16(7-8-23-27-21)17-10-18(22-11-15-9-13(4)25-26-15)20-19(24-17)14(5)28-29(20)12(2)3/h7-10,12H,6,11H2,1-5H3,(H,22,24)(H,25,26) YVJNUDZEHZHDAR-UHFFFAOYSA-N 462269 US10766893, Example 22b Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4.60 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462269 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462269&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138692672 441293472 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954463 CCOc1cnccc1-c1cc(NCc2cc(C)[nH]n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H27N7O/c1-6-30-20-12-23-8-7-17(20)18-10-19(24-11-16-9-14(4)26-27-16)22-21(25-18)15(5)28-29(22)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,24,25)(H,26,27) NGJDEXXIBVNLFY-UHFFFAOYSA-N 462270 US10766893, Example 23b Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 5.50 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462270 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462270&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138692730 441293473 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954466 CCOc1nnccc1-c1cc(NCc2cccc(OC)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O2/c1-6-32-23-17(10-11-25-28-23)18-12-19(24-13-16-8-7-9-20(26-16)31-5)22-21(27-18)15(4)29-30(22)14(2)3/h7-12,14H,6,13H2,1-5H3,(H,24,27) UOVIXKXDBWHQHI-UHFFFAOYSA-N 462271 US10766893, Example 24b Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 13.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462271 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462271&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138692681 441293474 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 955114 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1nncn1C InChI=1S/C18H23N9/c1-11(2)27-17-14(19-7-13-8-21-26(5)9-13)6-15(18-23-20-10-25(18)4)22-16(17)12(3)24-27/h6,8-11H,7H2,1-5H3,(H,19,22) KAIFDCSXZCWWKF-UHFFFAOYSA-N 279172 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-(4-methyl-1,2,4-triazol-3-::US10034861, Example 203::US10512632, Example 203::US10766893, Example S203::US10806718, Example 203::US11026923, Example 203::US11491140, Example 203::US11634416, Example 203 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 410 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279172 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279172&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273492 378160749 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954469 CCOc1cnccc1-c1cc(NCc2cccc(OC)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-21-14-25-11-10-18(21)19-12-20(26-13-17-8-7-9-22(27-17)31-5)24-23(28-19)16(4)29-30(24)15(2)3/h7-12,14-15H,6,13H2,1-5H3,(H,26,28) SFHHXFFUCFPQDI-UHFFFAOYSA-N 462272 US10766893, Example 25b Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 17.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462272 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462272&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138692759 441293475 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954472 CCOc1nnccc1-c1cc(NCc2cccc(F)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H24FN7O/c1-5-31-22-16(9-10-25-28-22)17-11-18(24-12-15-7-6-8-19(23)26-15)21-20(27-17)14(4)29-30(21)13(2)3/h6-11,13H,5,12H2,1-4H3,(H,24,27) LZZJYOXZQKENCS-UHFFFAOYSA-N 462273 US10766893, Example 26b Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 6.50 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462273 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462273&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138692715 441293476 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954475 CCOc1cnccc1-c1cc(NCc2ccn(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H27N7O/c1-6-30-20-13-23-9-7-17(20)18-11-19(24-12-16-8-10-28(5)27-16)22-21(25-18)15(4)26-29(22)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,24,25) RTFUGASLKHCGCN-UHFFFAOYSA-N 462274 US10766893, Example 27b Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 17.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462274 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462274&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138692728 441293477 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954478 CCOc1cnccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H27N7O/c1-6-30-20-12-23-8-7-17(20)18-9-19(24-10-16-11-25-28(5)13-16)22-21(26-18)15(4)27-29(22)14(2)3/h7-9,11-14H,6,10H2,1-5H3,(H,24,26) MKXYJEZIASGKJZ-UHFFFAOYSA-N 462275 US10766893, Example 28b Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 12.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462275 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462275&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138692680 441293478 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954481 COc1cnccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H25N7O/c1-13(2)28-21-18(23-9-15-10-24-27(4)12-15)8-17(25-20(21)14(3)26-28)16-6-7-22-11-19(16)29-5/h6-8,10-13H,9H2,1-5H3,(H,23,25) SVAHBGDAAWZCBA-UHFFFAOYSA-N 462276 US10766893, Example 29b Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 32.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462276 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462276&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138692764 441293479 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954484 CCOc1cnccc1-c1cc(NCc2cccnc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-21-14-25-11-9-18(21)19-12-20(27-13-17-8-7-10-26-24(17)31-5)23-22(28-19)16(4)29-30(23)15(2)3/h7-12,14-15H,6,13H2,1-5H3,(H,27,28) JIGCMFQAIKAHMI-UHFFFAOYSA-N 462277 US10766893, Example 30b Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 27.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462277 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462277&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138692662 441293480 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954487 CCCOc1cnccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H29N7O/c1-6-9-31-21-13-24-8-7-18(21)19-10-20(25-11-17-12-26-29(5)14-17)23-22(27-19)16(4)28-30(23)15(2)3/h7-8,10,12-15H,6,9,11H2,1-5H3,(H,25,27) GPAHSXIYBIOUFB-UHFFFAOYSA-N 462278 US10766893, Example 31b Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4.60 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462278 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462278&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138692706 441293481 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954490 CCOc1cnccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C23H29N7O/c1-6-15(3)30-23-20(25-11-17-12-26-29(5)14-17)10-19(27-22(23)16(4)28-30)18-8-9-24-13-21(18)31-7-2/h8-10,12-15H,6-7,11H2,1-5H3,(H,25,27) WJVBCQLIBYXTJE-UHFFFAOYSA-N 462279 US10766893, Example 32b Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 57.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462279&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138692666 441293482 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954493 CCOc1cnccc1-c1cc(NCc2nnc(C)o2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H25N7O2/c1-6-29-18-10-22-8-7-15(18)16-9-17(23-11-19-26-25-14(5)30-19)21-20(24-16)13(4)27-28(21)12(2)3/h7-10,12H,6,11H2,1-5H3,(H,23,24) OAHSZSQVXDBEJG-UHFFFAOYSA-N 462280 US10766893, Example 34b Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 49.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462280 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462280&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138692780 441293483 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954496 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1cccc2nc(C)oc12 InChI=1S/C23H25N7O/c1-13(2)30-22-20(24-10-16-11-25-29(5)12-16)9-19(27-21(22)14(3)28-30)17-7-6-8-18-23(17)31-15(4)26-18/h6-9,11-13H,10H2,1-5H3,(H,24,27) RZUPDLGZAIZBKU-UHFFFAOYSA-N 462281 US10766893, Example 35b::US10766893, Example 36b Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 39.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462281&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138692752 441293484 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954499 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1cccc2nc(C)oc12 InChI=1S/C23H25N7O/c1-13(2)30-22-20(24-10-16-11-25-29(5)12-16)9-19(27-21(22)14(3)28-30)17-7-6-8-18-23(17)31-15(4)26-18/h6-9,11-13H,10H2,1-5H3,(H,24,27) RZUPDLGZAIZBKU-UHFFFAOYSA-N 462281 US10766893, Example 35b::US10766893, Example 36b Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 14.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462281&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138692752 441293484 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954502 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1cccc2ncoc12 InChI=1S/C22H23N7O/c1-13(2)29-21-19(23-9-15-10-25-28(4)11-15)8-18(26-20(21)14(3)27-29)16-6-5-7-17-22(16)30-12-24-17/h5-8,10-13H,9H2,1-4H3,(H,23,26) BHFKZPHEMFPTRO-UHFFFAOYSA-N 462283 US10766893, Example 37b Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 16.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462283&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138692663 441293485 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954505 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1cccc2cc[nH]c12 InChI=1S/C23H25N7/c1-14(2)30-23-20(25-11-16-12-26-29(4)13-16)10-19(27-21(23)15(3)28-30)18-7-5-6-17-8-9-24-22(17)18/h5-10,12-14,24H,11H2,1-4H3,(H,25,27) YKKSPSQELFSSMW-UHFFFAOYSA-N 462284 US10766893, Example 38b Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 590 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462284&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138692703 441293486 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954508 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1cccc2cn[nH]c12 InChI=1S/C22H24N8/c1-13(2)30-22-19(23-9-15-10-25-29(4)12-15)8-18(26-20(22)14(3)28-30)17-7-5-6-16-11-24-27-21(16)17/h5-8,10-13H,9H2,1-4H3,(H,23,26)(H,24,27) JRLDYTVCZWOPME-UHFFFAOYSA-N 462285 US10766893, Example 39b Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 140 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462285&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 155903598 441293487 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954511 CCOc1ncccc1-c1cc(NCc2nnc(C)o2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H25N7O2/c1-6-29-21-15(8-7-9-22-21)16-10-17(23-11-18-26-25-14(5)30-18)20-19(24-16)13(4)27-28(20)12(2)3/h7-10,12H,6,11H2,1-5H3,(H,23,24) XEBJMVLHZBRKST-UHFFFAOYSA-N 278971 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methyl-1,3,4-oxadiazol-2-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 1::US10512632, Example 1::US10618913, Example S1::US10766893, Example S1::US10806718, Example 1::US11026923, Example 1::US11491140, Example 1::US11634416, Example 1 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 18.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278971 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278971&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273299 378160560 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954514 CCOc1ncccc1-c1cc(NCc2ncc(C)s2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6OS/c1-6-29-22-16(8-7-9-23-22)17-10-18(24-12-19-25-11-14(4)30-19)21-20(26-17)15(5)27-28(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,24,26) QOYNQFLWGDTXKT-UHFFFAOYSA-N 278972 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methylthiazol-2-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 2::US10512632, Example 2::US10766893, Example S2::US10806718, Example 2::US11026923, Example 2::US11491140, Example 2::US11634416, Example 2 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.460 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278972 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278972&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273301 378160561 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954517 CCOc1ncccc1-c1cc(NCc2cc(C)on2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6O2/c1-6-29-22-17(8-7-9-23-22)18-11-19(24-12-16-10-14(4)30-27-16)21-20(25-18)15(5)26-28(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,24,25) MKELJWFWEJOZNC-UHFFFAOYSA-N 278973 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methylisoxazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 3::US10512632, Example 3::US10766893, Example S3::US10806718, Example 3::US11026923, Example 3::US11491140, Example 3::US11634416, Example 3 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.800 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278973&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273302 378160562 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954520 CCOc1ncccc1-c1cc(NCc2cnc(C)o2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6O2/c1-6-29-22-17(8-7-9-23-22)18-10-19(25-12-16-11-24-15(5)30-16)21-20(26-18)14(4)27-28(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,25,26) TWDRBTLHNZMOLP-UHFFFAOYSA-N 278974 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methyloxazol-5-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 4::US10512632, Example 4::US10766893, Example S4::US10806718, Example 4::US11026923, Example 4::US11491140, Example 4::US11634416, Example 4 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.60 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278974 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278974&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273304 378160563 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954523 CCOc1ncccc1-c1cc(NCc2cnn(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-6-30-21-16(8-7-9-22-21)17-10-18(23-11-15-12-24-28(5)27-15)20-19(25-17)14(4)26-29(20)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,23,25) RKVBYUMNPKGITG-UHFFFAOYSA-N 278975 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methyltriazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 5::US10512632, Example 5::US10766893, Example S5::US10806718, Example 5::US11026923, Example 5::US11491140, Example 5::US11634416, Example 5 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 11.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278975&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273303 378160564 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954526 CCOc1ncccc1-c1cc(NCc2cn(C)nn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-6-30-21-16(8-7-9-22-21)17-10-18(23-11-15-12-28(5)27-25-15)20-19(24-17)14(4)26-29(20)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,23,24) GZZVSCZGHCUFQG-UHFFFAOYSA-N 278976 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(1-methyltriazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 6::US10512632, Example 6::US10766893, Example S6::US10806718, Example 6::US11026923, Example 6::US11491140, Example 6::US11634416, Example 6 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4.80 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278976&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273306 378160565 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954529 CCOc1ncccc1-c1cc(NCc2cn[nH]c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H25N7O/c1-5-29-21-16(7-6-8-22-21)17-9-18(23-10-15-11-24-25-12-15)20-19(26-17)14(4)27-28(20)13(2)3/h6-9,11-13H,5,10H2,1-4H3,(H,23,26)(H,24,25) ZBYZXMQLZZULRF-UHFFFAOYSA-N 278977 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1H-pyrazol-4-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 7::US10512632, Example 7::US10766893, Example S7::US10806718, Example 7::US11026923, Example 7::US11491140, Example 7::US11634416, Example 7 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 21.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278977 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278977&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 136214891 378160566 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954532 CCOc1ncccc1-c1cc(NCc2nnn(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C20H25N9O/c1-6-30-20-14(8-7-9-21-20)15-10-16(22-11-17-24-27-28(5)26-17)19-18(23-15)13(4)25-29(19)12(2)3/h7-10,12H,6,11H2,1-5H3,(H,22,23) MMFBNAADCPOKBP-UHFFFAOYSA-N 278978 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methyltetrazol-5-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 8::US10512632, Example 8::US10766893, Example S8::US10806718, Example 8::US11491140, Example 8::US11634416, Example 8 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.90 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278978&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273308 378160567 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954535 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H27N7O/c1-6-30-22-17(8-7-9-23-22)18-10-19(24-11-16-12-25-28(5)13-16)21-20(26-18)15(4)27-29(21)14(2)3/h7-10,12-14H,6,11H2,1-5H3,(H,24,26) IGZQEXMDAKABFO-UHFFFAOYSA-N 278979 5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 9::US10512632, Example 9::US10766893, Example S9::US10806718, Example 9::US11491140, Example 9::US11634416, Example 9 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.60 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278979&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273307 378160568 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954538 CCOc1ncccc1-c1cc(NCc2cc(C)no2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6O2/c1-6-29-22-17(8-7-9-23-22)18-11-19(24-12-16-10-14(4)27-30-16)21-20(25-18)15(5)26-28(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,24,25) WAUSGEZRVANNBG-UHFFFAOYSA-N 278980 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(3-methylisoxazol-5-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 10::US10512632, Example 10::US10766893, Example S10::US10806718, Example 10::US11491140, Example 10::US11634416, Example 10 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4.10 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278980 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278980&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273310 378160569 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954541 CCOc1ncccc1-c1cc(NCc2csc(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6OS/c1-6-29-22-17(8-7-9-23-22)18-10-19(24-11-16-12-30-15(5)25-16)21-20(26-18)14(4)27-28(21)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,24,26) YDCVOKZJZPJMKM-UHFFFAOYSA-N 278981 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methylthiazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 11::US10512632, Example 11::US10766893, Example S11::US10806718, Example 11::US11491140, Example 11::US11634416, Example 11 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 9.60 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278981&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273309 378160570 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954544 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C1CC1 InChI=1S/C22H25N7O/c1-4-30-22-17(6-5-9-23-22)18-10-19(24-11-15-12-25-28(3)13-15)21-20(26-18)14(2)27-29(21)16-7-8-16/h5-6,9-10,12-13,16H,4,7-8,11H2,1-3H3,(H,24,26) SVNBZNOJEMDHHP-UHFFFAOYSA-N 278982 1-cyclopropyl-5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 12::US10512632, Example 12::US10618913, Example S12::US10766893, Example S12::US10806718, Example 12::US11026923, Example 12::US11491140, Example 12 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 200 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278982&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273311 378160571 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954547 CCCn1ncc2nc(cc(NCc3cnn(C)c3)c12)-c1cccnc1OCC InChI=1S/C21H25N7O/c1-4-9-28-20-18(23-11-15-12-24-27(3)14-15)10-17(26-19(20)13-25-28)16-7-6-8-22-21(16)29-5-2/h6-8,10,12-14H,4-5,9,11H2,1-3H3,(H,23,26) VBBYLKGVLRZVDT-UHFFFAOYSA-N 278983 5-(2-ethoxy-3-pyridyl)-N-[(1-methylpyrazol-4-yl)methyl]-1-propyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 13::US10512632, Example 13::US10618913, Example S13::US10766893, Example S13::US10806718, Example 13::US11026923, Example 13::US11491140, Example 13::US11634416, Example 13 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 90.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278983 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278983&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273312 378160572 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954550 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(ncc2n1)C1COC1 InChI=1S/C21H23N7O2/c1-3-30-21-16(5-4-6-22-21)17-7-18(23-8-14-9-24-27(2)11-14)20-19(26-17)10-25-28(20)15-12-29-13-15/h4-7,9-11,15H,3,8,12-13H2,1-2H3,(H,23,26) BRAWZTIBDHEBNS-UHFFFAOYSA-N 278984 5-(2-ethoxypyridin-3-yl)-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1-(oxetan-3-yl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 14::US10512632, Example 14::US10618913, Example S14::US10766893, Example S14::US10806718, Example 14::US11026923, Example 14::US11491140, Example 14::US11634416, Example 14 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 450 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278984 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278984&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273313 378160573 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954553 CCOc1ncccc1-c1cc(NC(C)c2cnn(C)c2)c2n(C)ncc2n1 InChI=1S/C20H23N7O/c1-5-28-20-15(7-6-8-21-20)16-9-17(19-18(25-16)11-23-27(19)4)24-13(2)14-10-22-26(3)12-14/h6-13H,5H2,1-4H3,(H,24,25) PRZKTPKTSVRPRD-UHFFFAOYSA-N 278985 5-(2-ethoxypyridin-3-yl)-1-methyl-N-(1-(1-methyl-1H-pyrazol-4-yl)ethyl)-1H-pyrazolo[4,3-b]pyridin-7-amine (racemic)::US10034861, Example 15::US10766893, Example S15::US10806718, Example 15::US11026923, Example 15::US11491140, Example 15 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 820 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278985 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278985&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273314 378160574 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954556 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(C)ncc2n1 InChI=1S/C19H21N7O/c1-4-27-19-14(6-5-7-20-19)15-8-16(18-17(24-15)11-23-26(18)3)21-9-13-10-22-25(2)12-13/h5-8,10-12H,4,9H2,1-3H3,(H,21,24) IHPVHEUBCHVJEQ-UHFFFAOYSA-N 278986 5-(2-ethoxypyridin-3-yl)-1-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 16::US10512632, Example 16::US10766893, Example S16::US10806718, Example 16::US11026923, Example 16::US11491140, Example 16 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 670 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278986&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273315 378160575 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954559 CCOc1ncccc1-c1cc(NCc2nccn2C)c2n(ncc2n1)C(C)C InChI=1S/C21H25N7O/c1-5-29-21-15(7-6-8-23-21)16-11-17(24-13-19-22-9-10-27(19)4)20-18(26-16)12-25-28(20)14(2)3/h6-12,14H,5,13H2,1-4H3,(H,24,26) XRIYYPDCPKIHRW-UHFFFAOYSA-N 278987 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimidazol-2-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 17::US10512632, Example 17::US10618913, Example S17::US10766893, Example S17::US10806718, Example 17::US11026923, Example 17::US11491140, Example 17::US11634416, Example 17 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 700 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278987 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278987&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273316 378160576 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954562 CCOc1ncccc1-c1cc(NCc2ccnn2C)c2n(ncc2n1)C(C)C InChI=1S/C21H25N7O/c1-5-29-21-16(7-6-9-22-21)17-11-18(23-12-15-8-10-24-27(15)4)20-19(26-17)13-25-28(20)14(2)3/h6-11,13-14H,5,12H2,1-4H3,(H,23,26) ARZYUJKMHFQSRW-UHFFFAOYSA-N 278988 5-(2-ethoxypyridin-3-yl)-1-isopropyl-N-((1-methyl-1H-pyrazol-5-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 18::US10512632, Example 18::US10766893, Example S18::US10806718, Example 18::US11026923, Example 18::US11491140, Example 18::US11634416, Example 18 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 450 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278988&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273317 378160577 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954565 CCOc1ncccc1-c1cc(NCc2ccn(C)n2)c2n(ncc2n1)C(C)C InChI=1S/C21H25N7O/c1-5-29-21-16(7-6-9-22-21)17-11-18(23-12-15-8-10-27(4)26-15)20-19(25-17)13-24-28(20)14(2)3/h6-11,13-14H,5,12H2,1-4H3,(H,23,25) KZFYUJZMDBTCDC-UHFFFAOYSA-N 278989 5-(2-ethoxypyridin-3-yl)-1-isopropyl-N-((1-methyl-1H-pyrazol-3-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 19::US10512632, Example 19::US10766893, Example S19::US10806718, Example 19::US11026923, Example 19::US11491140, Example 19::US11634416, Example 19 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 66.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278989 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278989&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273318 378160578 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954568 CCOc1ncccc1-c1cc(NCc2nccs2)c2n(ncc2n1)C(C)C InChI=1S/C20H22N6OS/c1-4-27-20-14(6-5-7-22-20)15-10-16(23-12-18-21-8-9-28-18)19-17(25-15)11-24-26(19)13(2)3/h5-11,13H,4,12H2,1-3H3,(H,23,25) ICTYYJZHJNSZFG-UHFFFAOYSA-N 278990 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-(thiazol-2-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 20::US10512632, Example 20::US10766893, Example S20::US10806718, Example 20::US11026923, Example 20::US11491140, Example 20::US11634416, Example 20 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 520 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278990&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273319 378160579 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954571 CCOc1ncccc1-c1cc(NCc2cn(C)cn2)c2n(ncc2n1)C(C)C InChI=1S/C21H25N7O/c1-5-29-21-16(7-6-8-22-21)17-9-18(23-10-15-12-27(4)13-24-15)20-19(26-17)11-25-28(20)14(2)3/h6-9,11-14H,5,10H2,1-4H3,(H,23,26) GPZPPQFWVLHHBU-UHFFFAOYSA-N 278991 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimidazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 21::US10512632, Example 21::US10766893, Example S21::US10806718, Example 21::US11026923, Example 21::US11491140, Example 21::US11634416, Example 21 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.90 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278991&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273320 378160580 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954574 CCOc1ncccc1-c1cc(NCc2ccncc2)c2n(ncc2n1)C(C)C InChI=1S/C22H24N6O/c1-4-29-22-17(6-5-9-24-22)18-12-19(25-13-16-7-10-23-11-8-16)21-20(27-18)14-26-28(21)15(2)3/h5-12,14-15H,4,13H2,1-3H3,(H,25,27) HEERUKANWGHTOL-UHFFFAOYSA-N 278992 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-(4-pyridylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 22::US10512632, Example 22::US10766893, Example S22::US10806718, Example 22::US11026923, Example 22::US11491140, Example 22::US11634416, Example 22 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 250 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278992&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273322 378160581 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954577 CCOc1ncccc1-c1cc(NCc2cccc(C)c2)c2n(ncc2n1)C(C)C InChI=1S/C24H27N5O/c1-5-30-24-19(10-7-11-25-24)20-13-21(26-14-18-9-6-8-17(4)12-18)23-22(28-20)15-27-29(23)16(2)3/h6-13,15-16H,5,14H2,1-4H3,(H,26,28) NOGPVEPEDSPNHF-UHFFFAOYSA-N 278993 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-(m-tolylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 23::US10512632, Example 23::US10618913, Example S23::US10766893, Example S23::US10806718, Example 23::US11026923, Example 23::US11491140, Example 23::US11634416, Example 23 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 240 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278993&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273321 378160582 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954580 CCOc1ncccc1-c1cc(NCc2ccc(C)cc2)c2n(ncc2n1)C(C)C InChI=1S/C24H27N5O/c1-5-30-24-19(7-6-12-25-24)20-13-21(26-14-18-10-8-17(4)9-11-18)23-22(28-20)15-27-29(23)16(2)3/h6-13,15-16H,5,14H2,1-4H3,(H,26,28) KLXXAXDPPNWJOU-UHFFFAOYSA-N 278994 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-(p-tolylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 24::US10512632, Example 24::US10766893, Example S24::US10806718, Example 24::US11026923, Example 24::US11491140, Example 24::US11634416, Example 24 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 380 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278994&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273323 378160583 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954583 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(ncc2n1)C(C)C InChI=1S/C21H25N7O/c1-5-29-21-16(7-6-8-22-21)17-9-18(23-10-15-11-24-27(4)13-15)20-19(26-17)12-25-28(20)14(2)3/h6-9,11-14H,5,10H2,1-4H3,(H,23,26) PLERDTYSXFBCOL-UHFFFAOYSA-N 278995 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 25::US10512632, Example 25::US10766893, Example S25::US10806718, Example 25::US11026923, Example 25::US11491140, Example 25::US11634416, Example 25 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 56.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278995&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273324 378160584 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954586 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(CC)ncc2n1 InChI=1S/C20H23N7O/c1-4-27-19-17(22-10-14-11-23-26(3)13-14)9-16(25-18(19)12-24-27)15-7-6-8-21-20(15)28-5-2/h6-9,11-13H,4-5,10H2,1-3H3,(H,22,25) GDQVLYVPAWKIKI-UHFFFAOYSA-N 424936 US10512632, Example 26::US10618913, Example S26::US10766893, Example S26::US10806718, Example 26::US11026923, Example 26::US11491140, Example 26::US11634416, Example 26 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 140 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=424936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=424936&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138536209 434150491 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954589 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C1COC1 InChI=1S/C22H25N7O2/c1-4-31-22-17(6-5-7-23-22)18-8-19(24-9-15-10-25-28(3)11-15)21-20(26-18)14(2)27-29(21)16-12-30-13-16/h5-8,10-11,16H,4,9,12-13H2,1-3H3,(H,24,26) HKTCICUQHUTDJM-UHFFFAOYSA-N 278997 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-1-(oxetan-3-yl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 27::US10512632, Example 27::US10766893, Example S27::US10806718, Example 27::US11026923, Example 27::US11491140, Example 27::US11634416, Example 27 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 94.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278997 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278997&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273326 378160586 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954592 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(C)nc(C)c2n1 InChI=1S/C20H23N7O/c1-5-28-20-15(7-6-8-21-20)16-9-17(22-10-14-11-23-26(3)12-14)19-18(24-16)13(2)25-27(19)4/h6-9,11-12H,5,10H2,1-4H3,(H,22,24) GGQMHLLGYDUHDQ-UHFFFAOYSA-N 278998 5-(2-ethoxy-3-pyridyl)-1,3-dimethyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 28::US10512632, Example 28::US10618913, Example S28::US10766893, Example S28::US10806718, Example 28::US11026923, Example 28::US11491140, Example 28::US11634416, Example 28 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 550 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278998 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278998&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273327 378160587 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954595 CCOc1ncccc1-c1cc(NCc2nc(C)cs2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6OS/c1-6-29-22-16(8-7-9-23-22)17-10-18(24-11-19-25-14(4)12-30-19)21-20(26-17)15(5)27-28(21)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,24,26) WFSFSRAGPIZNCC-UHFFFAOYSA-N 278999 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(4-methylthiazol-2-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 29::US10512632, Example 29::US10618913, Example S162::US10766893, Example S29::US10806718, Example 29::US11026923, Example 29::US11491140, Example 29::US11634416, Example 29 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 27.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278999 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278999&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273328 378160588 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954598 CCOc1ncccc1-c1cc(NCc2nc(C)no2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H25N7O2/c1-6-29-21-15(8-7-9-22-21)16-10-17(23-11-18-24-14(5)27-30-18)20-19(25-16)13(4)26-28(20)12(2)3/h7-10,12H,6,11H2,1-5H3,(H,23,25) ZPMKSBYSMXCOIZ-UHFFFAOYSA-N 279000 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(3-methyl-1,2,4-oxadiazol-5-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 30::US10512632, Example 30::US10766893, Example S30::US10806718, Example 30::US11026923, Example 30::US11491140, Example 30::US11634416, Example 30 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 15.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279000 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279000&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273329 378160589 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954601 CCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-6-30-21-15(8-7-9-22-21)16-10-17(23-11-18-24-12-28(5)27-18)20-19(25-16)14(4)26-29(20)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,23,25) CJOUFKUESMXTOX-UHFFFAOYSA-N 279001 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 161::US10034861, Example 31::US10512632, Example 31::US10766893, Example S31::US10806718, Example 31::US11026923, Example 31::US11491140, Example 31::US11634416, Example 31 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.20 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279001 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279001&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273330 378160590 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954604 CCOc1ncccc1-c1cc(NCc2cnc(C)s2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6OS/c1-6-29-22-17(8-7-9-23-22)18-10-19(25-12-16-11-24-15(5)30-16)21-20(26-18)14(4)27-28(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,25,26) UJFBEAPRUYBIKE-UHFFFAOYSA-N 279002 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methylthiazol-5-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 32::US10512632, Example 32::US10766893, Example S32::US10806718, Example 32::US11026923, Example 32::US11491140, Example 32::US11634416, Example 32 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4.60 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279002&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273331 378160591 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954607 CCOc1ncccc1-c1cc(NCc2nnc(C)s2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H25N7OS/c1-6-29-21-15(8-7-9-22-21)16-10-17(23-11-18-26-25-14(5)30-18)20-19(24-16)13(4)27-28(20)12(2)3/h7-10,12H,6,11H2,1-5H3,(H,23,24) XQUFGMNXDPCXMM-UHFFFAOYSA-N 279003 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methyl-1,3,4-thiadiazol-2-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 33::US10512632, Example 33::US10766893, Example S33::US10806718, Example 33::US11026923, Example 33::US11491140, Example 33::US11634416, Example 33 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.60 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279003 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279003&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273332 378160592 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954610 CCOc1ncccc1-c1cc(NCc2csc(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N5OS/c1-6-29-23-18(8-7-9-24-23)19-11-20(25-12-17-10-15(4)30-13-17)22-21(26-19)16(5)27-28(22)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,25,26) VNCLCBKVWWHCAF-UHFFFAOYSA-N 279004 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methyl-3-thienyl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 34::US10512632, Example 34::US10766893, Example S34::US10806718, Example 34::US11026923, Example 34::US11491140, Example 34::US11634416, Example 34 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.10 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279004 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279004&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273333 378160593 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954613 CCOc1ncccc1-c1cc(NCc2cc(C)cs2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N5OS/c1-6-29-23-18(8-7-9-24-23)19-11-20(25-12-17-10-15(4)13-30-17)22-21(26-19)16(5)27-28(22)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,25,26) DHODKXCCORNYHA-UHFFFAOYSA-N 279005 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(4-methyl-2-thienyl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 35::US10512632, Example 35::US10766893, Example S35::US10806718, Example 35::US11026923, Example 35::US11491140, Example 35::US11634416, Example 35 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 7.30 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279005 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279005&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273334 378160594 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954616 CCOc1ncccc1-c1cc(NCc2ccc(C)s2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N5OS/c1-6-29-23-18(8-7-11-24-23)19-12-20(25-13-17-10-9-15(4)30-17)22-21(26-19)16(5)27-28(22)14(2)3/h7-12,14H,6,13H2,1-5H3,(H,25,26) MXNGXYQZCMFPJD-UHFFFAOYSA-N 279006 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methyl-2-thienyl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 36::US10512632, Example 36::US10766893, Example S36::US10806718, Example 36::US11026923, Example 36::US11491140, Example 36::US11634416, Example 36 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 24.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279006&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273337 378160595 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954619 CCOc1ncccc1-c1cc(NCc2coc(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6O2/c1-6-29-22-17(8-7-9-23-22)18-10-19(24-11-16-12-30-15(5)25-16)21-20(26-18)14(4)27-28(21)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,24,26) VZTGUNQMZSOPTA-UHFFFAOYSA-N 279007 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methyloxazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 37::US10512632, Example 37::US10766893, Example S37::US10806718, Example 37::US11026923, Example 37::US11491140, Example 37::US11634416, Example 37 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 5.90 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279007 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279007&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273335 378160596 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954622 CCOc1ncccc1-c1cc(NCc2ncc(C)o2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6O2/c1-6-29-22-16(8-7-9-23-22)17-10-18(24-12-19-25-11-14(4)30-19)21-20(26-17)15(5)27-28(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,24,26) IGMSFVIKHQRGSP-UHFFFAOYSA-N 279008 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methyloxazol-2-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 38::US10512632, Example 38::US10766893, Example S38::US10806718, Example 38::US11026923, Example 38::US11491140, Example 38::US11634416, Example 38 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.10 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279008 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279008&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273338 378160597 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954625 CCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H25N7O/c1-5-29-21-16(7-6-9-22-21)17-11-18(23-12-15-8-10-24-26-15)20-19(25-17)14(4)27-28(20)13(2)3/h6-11,13H,5,12H2,1-4H3,(H,23,25)(H,24,26) UOWVOVPKNPTQQH-UHFFFAOYSA-N 279009 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 39::US10512632, Example 39::US10766893, Example S39::US10806718, Example 39::US11026923, Example 39::US11491140, Example 39::US11634416, Example 39 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.10 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279009 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279009&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273340 378160598 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954628 CCOc1ncccc1-c1cc(NCc2c[nH]cn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H25N7O/c1-5-29-21-16(7-6-8-23-21)17-9-18(24-11-15-10-22-12-25-15)20-19(26-17)14(4)27-28(20)13(2)3/h6-10,12-13H,5,11H2,1-4H3,(H,22,25)(H,24,26) IQIUSKXHLPBBOV-UHFFFAOYSA-N 279010 5-(2-ethoxy-3-pyridyl)-N-(1H-imidazol-4-ylmethyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 40::US10512632, Example 40::US10766893, Example S40::US10806718, Example 40::US11026923, Example 40::US11491140, Example 40::US11634416, Example 40 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 14.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279010 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279010&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273339 378160599 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954631 CCOc1ncccc1-c1cc(NCc2ccccc2)c2n(ncc2n1)C(C)C InChI=1S/C23H25N5O/c1-4-29-23-18(11-8-12-24-23)19-13-20(25-14-17-9-6-5-7-10-17)22-21(27-19)15-26-28(22)16(2)3/h5-13,15-16H,4,14H2,1-3H3,(H,25,27) CAHURFTWFHHOPU-UHFFFAOYSA-N 279011 N-benzyl-5-(2-ethoxy-3-pyridyl)-1-isopropyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 41::US10512632, Example 41::US10618913, Example S41::US10766893, Example S41::US10806718, Example 41::US11026923, Example 41::US11634416, Example 41 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 500 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279011 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279011&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273336 378160600 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954634 CCOc1ncccc1-c1cc(NCc2cc(C)no2)c2n(ncc2n1)C(C)C InChI=1S/C21H24N6O2/c1-5-28-21-16(7-6-8-22-21)17-10-18(23-11-15-9-14(4)26-29-15)20-19(25-17)12-24-27(20)13(2)3/h6-10,12-13H,5,11H2,1-4H3,(H,23,25) ZGFGKVRUAVJQMR-UHFFFAOYSA-N 279012 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(3-methylisoxazol-5-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 42::US10512632, Example 42::US10766893, Example S42::US10806718, Example 42::US11026923, Example 42::US11634416, Example 42 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 82.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279012&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273341 378160601 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954637 CCOc1ncccc1-c1cc(NCc2noc(C)n2)c2n(ncc2n1)C(C)C InChI=1S/C20H23N7O2/c1-5-28-20-14(7-6-8-21-20)15-9-16(22-11-18-24-13(4)29-26-18)19-17(25-15)10-23-27(19)12(2)3/h6-10,12H,5,11H2,1-4H3,(H,22,25) SDTZIRBETDMBLS-UHFFFAOYSA-N 279013 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 43::US10512632, Example 43::US10766893, Example S43::US10806718, Example 43::US11026923, Example 43::US11634416, Example 43 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 30.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279013&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273344 378160602 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954640 CCOc1ncccc1-c1cc(NCc2cc(C)n(C)n2)c2n(ncc2n1)C(C)C InChI=1S/C22H27N7O/c1-6-30-22-17(8-7-9-23-22)18-11-19(24-12-16-10-15(4)28(5)27-16)21-20(26-18)13-25-29(21)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,24,26) RWTZKAWRGHZQKR-UHFFFAOYSA-N 279014 N-[(1,5-dimethylpyrazol-3-yl)methyl]-5-(2-ethoxy-3-pyridyl)-1-isopropyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 44::US10512632, Example 44::US10766893, Example S44::US10806718, Example 44::US11026923, Example 44::US11634416, Example 44 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 19.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279014 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279014&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273342 378160603 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954643 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1cccn(C)c1=O InChI=1S/C21H25N7O/c1-13(2)28-20-18(22-10-15-11-23-27(5)12-15)9-17(24-19(20)14(3)25-28)16-7-6-8-26(4)21(16)29/h6-9,11-13H,10H2,1-5H3,(H,22,24) MRQVRXHGMURIIP-UHFFFAOYSA-N 279019 3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4-yl)methyl)amino)-1H-pyrazolo[4,3-b]pyridin-5-yl)-1-methylpyridin-2(1H)-one::US10034861, Example 49::US10512632, Example 49::US10766893, Example S49::US10806718, Example 49::US11026923, Example 49::US11491140, Example 49::US11634416, Example 49 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.00 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279019 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279019&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273348 378160608 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954646 CCOc1ncccc1-c1cc(NCc2c[nH]c(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H27N7O/c1-6-30-22-17(8-7-9-23-22)18-10-19(25-12-16-11-24-15(5)26-16)21-20(27-18)14(4)28-29(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,24,26)(H,25,27) OESORFJHOJQXKR-UHFFFAOYSA-N 279016 5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((2-methyl-1H-imidazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 46::US10512632, Example 46::US10766893, Example S46::US10806718, Example 46::US11026923, Example 46::US11491140, Example 46::US11634416, Example 46 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 5.00 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279016&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273345 378160605 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954649 CCOc1ncccc1-c1cc(NCc2cc(C)[nH]n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H27N7O/c1-6-30-22-17(8-7-9-23-22)18-11-19(24-12-16-10-14(4)26-27-16)21-20(25-18)15(5)28-29(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,24,25)(H,26,27) BKIZQOUWXXJIIE-UHFFFAOYSA-N 279017 5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((5-methyl-1H-pyrazol-3-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 47::US10512632, Example 47::US10766893, Example S54::US10806718, Example 47::US11026923, Example 47::US11491140, Example 47::US11634416, Example 47 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.60 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279017&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273346 378160606 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954652 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(CC)nc(C)c2n1 InChI=1S/C21H25N7O/c1-5-28-20-18(23-11-15-12-24-27(4)13-15)10-17(25-19(20)14(3)26-28)16-8-7-9-22-21(16)29-6-2/h7-10,12-13H,5-6,11H2,1-4H3,(H,23,25) ALQSQGPOANFHOP-UHFFFAOYSA-N 279018 5-(2-ethoxypyridin-3-yl)-1-ethyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 48::US10512632, Example 48::US10618913, Example S48::US10766893, Example S48::US10806718, Example 48::US11026923, Example 48::US11491140, Example 48::US11634416, Example 48 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 38.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279018&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273347 378160607 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954655 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1cccn(C)c1=O InChI=1S/C21H25N7O/c1-13(2)28-20-18(22-10-15-11-23-27(5)12-15)9-17(24-19(20)14(3)25-28)16-7-6-8-26(4)21(16)29/h6-9,11-13H,10H2,1-5H3,(H,22,24) MRQVRXHGMURIIP-UHFFFAOYSA-N 279019 3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4-yl)methyl)amino)-1H-pyrazolo[4,3-b]pyridin-5-yl)-1-methylpyridin-2(1H)-one::US10034861, Example 49::US10512632, Example 49::US10766893, Example S49::US10806718, Example 49::US11026923, Example 49::US11491140, Example 49::US11634416, Example 49 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 170 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279019 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279019&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273348 378160608 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954658 CCOc1ncccc1-c1cc(NCc2nc(C)co2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6O2/c1-6-29-22-16(8-7-9-23-22)17-10-18(24-11-19-25-14(4)12-30-19)21-20(26-17)15(5)27-28(21)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,24,26) LWOWQQZYEXAZTD-UHFFFAOYSA-N 279020 5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((4-methyloxazol-2-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine 2,2,2-trifluoroacetate::US10034861, Example 50::US10512632, Example 50::US10766893, Example S50::US10806718, Example 50::US11026923, Example 50::US11491140, Example 50::US11634416, Example 50 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 9.00 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279020 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279020&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273350 378160609 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954661 CCOc1ncccc1-c1cc(NCc2cn(C)c(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H29N7O/c1-7-31-23-18(9-8-10-24-23)19-11-20(25-12-17-13-29(6)16(5)26-17)22-21(27-19)15(4)28-30(22)14(2)3/h8-11,13-14H,7,12H2,1-6H3,(H,25,27) RIBLUNUCLUPFGL-UHFFFAOYSA-N 279021 N-((1,2-dimethyl-1H-imidazol-4-yl)methyl)-5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-1H-pyrazolo[4,3-b]pyridin-7-amine 2,2,2-trifluoroacetate::US10034861, Example 51::US10512632, Example 51::US10766893, Example S51::US10806718, Example 51::US11026923, Example 51::US11491140, Example 51::US11634416, Example 51 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 53.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279021 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279021&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273354 378160610 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954664 CCOc1ncccc1-c1cc(NCc2noc(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H25N7O2/c1-6-29-21-15(8-7-9-22-21)16-10-17(23-11-18-24-14(5)30-27-18)20-19(25-16)13(4)26-28(20)12(2)3/h7-10,12H,6,11H2,1-5H3,(H,23,25) GALBTAGDVOLYTK-UHFFFAOYSA-N 279022 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 52::US10512632, Example 52::US10766893, Example S52::US10806718, Example 52::US11026923, Example 52::US11491140, Example 52 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.90 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279022 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279022&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273351 378160611 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954667 CCOc1ncccc1-c1cc(NCc2ncon2)c2n(nc(C)c2n1)C(C)C InChI=1S/C20H23N7O2/c1-5-28-20-14(7-6-8-21-20)15-9-16(22-10-17-23-11-29-26-17)19-18(24-15)13(4)25-27(19)12(2)3/h6-9,11-12H,5,10H2,1-4H3,(H,22,24) HUAHNRHWFFYRAT-UHFFFAOYSA-N 279023 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1,2,4-oxadiazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 53::US10512632, Example 53::US10766893, Example S53::US10806718, Example 53::US11026923, Example 53::US11491140, Example 53::US11634416, Example 53 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 9.30 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279023&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273357 378160612 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954670 CCOc1ncccc1-c1cc(NCc2cc(C)[nH]n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H27N7O/c1-6-30-22-17(8-7-9-23-22)18-11-19(24-12-16-10-14(4)26-27-16)21-20(25-18)15(5)28-29(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,24,25)(H,26,27) BKIZQOUWXXJIIE-UHFFFAOYSA-N 279017 5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((5-methyl-1H-pyrazol-3-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 47::US10512632, Example 47::US10766893, Example S54::US10806718, Example 47::US11026923, Example 47::US11491140, Example 47::US11634416, Example 47 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.390 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279017&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273346 378160606 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954673 CCOc1ncccc1-c1cc(NCc2n[nH]c(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-6-30-21-15(8-7-9-22-21)16-10-17(23-11-18-24-14(5)26-27-18)20-19(25-16)13(4)28-29(20)12(2)3/h7-10,12H,6,11H2,1-5H3,(H,23,25)(H,24,26,27) QVFBWQCMGPADBC-UHFFFAOYSA-N 279025 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methyl-1H-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 55::US10512632, Example 55::US10766893, Example S55::US10806718, Example 55::US11026923, Example 55::US11491140, Example 55::US11634416, Example 55 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 3.40 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279025&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273353 378160614 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954676 CCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(ncc2n1)C(C)C InChI=1S/C20H24N8O/c1-5-29-20-14(7-6-8-21-20)15-9-16(22-11-18-23-12-27(4)26-18)19-17(25-15)10-24-28(19)13(2)3/h6-10,12-13H,5,11H2,1-4H3,(H,22,25) LBAWYUCYPDZBSF-UHFFFAOYSA-N 279026 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 56::US10512632, Example 56::US10766893, Example S56::US10806718, Example 56::US11026923, Example 56::US11491140, Example 56::US11634416, Example 56 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 16.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279026&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273358 378160615 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954679 CCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(ncc2n1)C(C)C InChI=1S/C20H23N7O/c1-4-28-20-15(6-5-8-21-20)16-10-17(22-11-14-7-9-23-26-14)19-18(25-16)12-24-27(19)13(2)3/h5-10,12-13H,4,11H2,1-3H3,(H,22,25)(H,23,26) RZEYZCLEVMBHDS-UHFFFAOYSA-N 279027 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 57::US10512632, Example 57::US10766893, Example S57::US10806718, Example 57::US11026923, Example 57::US11491140, Example 57::US11634416, Example 57 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 98.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279027&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273355 378160616 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954682 CCOc1ncccc1-c1cc(NCc2cn(C)cn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H27N7O/c1-6-30-22-17(8-7-9-23-22)18-10-19(24-11-16-12-28(5)13-25-16)21-20(26-18)15(4)27-29(21)14(2)3/h7-10,12-14H,6,11H2,1-5H3,(H,24,26) LRTCNZDFQQIFPH-UHFFFAOYSA-N 279028 5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((1-methyl-1H-imidazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine 2,2,2-trifluoroacetate::US10034861, Example 58::US10512632, Example 58::US10766893, Example S58::US10806718, Example 58::US11026923, Example 58::US11491140, Example 58::US11634416, Example 58 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.10 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279028&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273360 378160617 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954685 CCOc1ncccc1-c1cc(NCc2nnco2)c2n(nc(C)c2n1)C(C)C InChI=1S/C20H23N7O2/c1-5-28-20-14(7-6-8-21-20)15-9-16(22-10-17-25-23-11-29-17)19-18(24-15)13(4)26-27(19)12(2)3/h6-9,11-12H,5,10H2,1-4H3,(H,22,24) AHFKEZBAZQXEDY-UHFFFAOYSA-N 279029 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1,3,4-oxadiazol-2-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 59::US10512632, Example 59::US10766893, Example S59::US10806718, Example 59::US11026923, Example 59::US11491140, Example 59::US11634416, Example 59 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 55.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279029&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273356 378160618 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954688 CCOc1ncccc1-c1cc(NCc2ccn(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H27N7O/c1-6-30-22-17(8-7-10-23-22)18-12-19(24-13-16-9-11-28(5)27-16)21-20(25-18)15(4)26-29(21)14(2)3/h7-12,14H,6,13H2,1-5H3,(H,24,25) FXMRNOZDEMMBMY-UHFFFAOYSA-N 279030 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(1-methylpyrazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 60::US10512632, Example 60::US10766893, Example S60::US10806718, Example 60::US11491140, Example 60::US11634416, Example 60 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 6.50 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279030&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273369 378160619 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954691 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1cn(C)nc1C InChI=1S/C20H26N8/c1-12(2)28-20-18(21-8-15-9-22-26(5)10-15)7-17(23-19(20)14(4)25-28)16-11-27(6)24-13(16)3/h7,9-12H,8H2,1-6H3,(H,21,23) SZOKENQFAYLAJE-UHFFFAOYSA-N 279031 5-(1,3-dimethylpyrazol-4-yl)-1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 61::US10512632, Example 61::US10618913, Example S61::US10766893, Example S61::US10806718, Example 61::US11491140, Example 61::US11634416, Example 61 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 550 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279031&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273370 378160620 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954694 COc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H25N7O/c1-13(2)28-20-18(23-10-15-11-24-27(4)12-15)9-17(25-19(20)14(3)26-28)16-7-6-8-22-21(16)29-5/h6-9,11-13H,10H2,1-5H3,(H,23,25) NDQZTZXQHDYXCS-UHFFFAOYSA-N 279032 1-isopropyl-5-(2-methoxy-3-pyridyl)-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 62::US10512632, Example 62::US10766893, Example S62::US10806718, Example 62::US11491140, Example 62::US11634416, Example 62 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 16.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279032&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273362 378160621 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954697 COc1ccccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6O/c1-14(2)28-22-19(23-11-16-12-24-27(4)13-16)10-18(25-21(22)15(3)26-28)17-8-6-7-9-20(17)29-5/h6-10,12-14H,11H2,1-5H3,(H,23,25) KTDTYSKLFCIVHF-UHFFFAOYSA-N 279033 1-isopropyl-5-(2-methoxyphenyl)-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 63::US10512632, Example 63::US10766893, Example S63::US10806718, Example 63::US11491140, Example 63::US11634416, Example 63 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 64.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279033&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273359 378160622 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954700 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1ccccc1 InChI=1S/C21H24N6/c1-14(2)27-21-19(22-11-16-12-23-26(4)13-16)10-18(17-8-6-5-7-9-17)24-20(21)15(3)25-27/h5-10,12-14H,11H2,1-4H3,(H,22,24) JFQFIBIPASGZMG-UHFFFAOYSA-N 279034 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-phenyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 64::US10512632, Example 64::US10766893, Example S64::US10806718, Example 64::US11491140, Example 64::US11634416, Example 64 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 52.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279034&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273365 378160623 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954703 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1ccsc1C InChI=1S/C20H24N6S/c1-12(2)26-20-18(21-9-15-10-22-25(5)11-15)8-17(16-6-7-27-14(16)4)23-19(20)13(3)24-26/h6-8,10-12H,9H2,1-5H3,(H,21,23) OOGMCENLMFETDO-UHFFFAOYSA-N 279035 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-(2-methyl-3-thienyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 65::US10512632, Example 65::US10766893, Example S65::US10806718, Example 65::US11491140, Example 65::US11634416, Example 65 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 7.90 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279035&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273363 378160624 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954706 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1cnn(C)c1C InChI=1S/C20H26N8/c1-12(2)28-20-18(21-8-15-9-22-26(5)11-15)7-17(24-19(20)13(3)25-28)16-10-23-27(6)14(16)4/h7,9-12H,8H2,1-6H3,(H,21,24) IOBLPVSVJNVETM-UHFFFAOYSA-N 279036 5-(1,5-dimethylpyrazol-4-yl)-1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 66::US10512632, Example 66::US10766893, Example S66::US10806718, Example 66::US11491140, Example 66::US11634416, Example 66 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 210 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279036&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273361 378160625 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954709 CCOc1ncccc1-c1cc(NCc2ccn(C)n2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C23H29N7O/c1-6-15(3)30-22-20(25-14-17-10-12-29(5)28-17)13-19(26-21(22)16(4)27-30)18-9-8-11-24-23(18)31-7-2/h8-13,15H,6-7,14H2,1-5H3,(H,25,26) GUZUXYPWYDLGJF-UHFFFAOYSA-N 279037 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]-N-[(1-methylpyrazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 67::US10512632, Example 67::US10618913, Example S67::US10766893, Example S67::US10806718, Example 67::US11634416, Example 67 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 9.60 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279037 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279037&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273371 378160626 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954712 CCCOc1ncccc1-c1cc(NCc2nnn(C)n2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C22H29N9O/c1-6-11-32-22-16(9-8-10-23-22)17-12-18(24-13-19-26-29-30(5)28-19)21-20(25-17)15(4)27-31(21)14(3)7-2/h8-10,12,14H,6-7,11,13H2,1-5H3,(H,24,25) DGDYHVXCROBNNK-UHFFFAOYSA-N 279038 3-methyl-1-[1-methylpropyl]-N-[(2-methyltetrazol-5-yl)methyl]-5-(2-propoxy-3-pyridyl)pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 68::US10512632, Example 68::US10766893, Example S68::US10806718, Example 68::US11634416, Example 68 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.790 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279038 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279038&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273364 378160627 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954715 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(ncc2n1)C(C)CC InChI=1S/C22H27N7O/c1-5-15(3)29-21-19(24-11-16-12-25-28(4)14-16)10-18(27-20(21)13-26-29)17-8-7-9-23-22(17)30-6-2/h7-10,12-15H,5-6,11H2,1-4H3,(H,24,27) PNGBBNJWUZFNIY-UHFFFAOYSA-N 279039 5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine, enantiomer 1::US10034861, Example 69::US10034861, Example 70::US10512632, Example 70::US10618913, Example S69::US10766893, Example S70::US10806718, Example 70::US11634416, Example 70 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 14.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279039&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273366 378160628 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954718 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(ncc2n1)C(C)CC InChI=1S/C22H27N7O/c1-5-15(3)29-21-19(24-11-16-12-25-28(4)14-16)10-18(27-20(21)13-26-29)17-8-7-9-23-22(17)30-6-2/h7-10,12-15H,5-6,11H2,1-4H3,(H,24,27) PNGBBNJWUZFNIY-UHFFFAOYSA-N 279039 5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine, enantiomer 1::US10034861, Example 69::US10034861, Example 70::US10512632, Example 70::US10618913, Example S69::US10766893, Example S70::US10806718, Example 70::US11634416, Example 70 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 140 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279039&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273366 378160628 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954721 CCOc1ncccc1-c1cc(NCc2scnc2C)c2n(ncc2n1)C(C)C InChI=1S/C21H24N6OS/c1-5-28-21-15(7-6-8-22-21)16-9-17(23-11-19-14(4)24-12-29-19)20-18(26-16)10-25-27(20)13(2)3/h6-10,12-13H,5,11H2,1-4H3,(H,23,26) CKGZFAMXPLRINR-UHFFFAOYSA-N 424981 US10512632, Example 71::US10766893, Example S71::US10806718, Example 71::US11026923, Example 71::US11491140, Example 71::US11634416, Example 71 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 170 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=424981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=424981&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138536011 434150492 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954724 CCOc1ncccc1-c1cc(OCc2cnc(C)o2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H25N5O3/c1-6-28-22-17(8-7-9-23-22)18-10-19(29-12-16-11-24-15(5)30-16)21-20(25-18)14(4)26-27(21)13(2)3/h7-11,13H,6,12H2,1-5H3 PFDYAXRVKURLCH-UHFFFAOYSA-N 279042 5-[[5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-yl]oxymethyl]-2-methyl-oxazole::US10034861, Example 72::US10512632, Example 72::US10766893, Example S72::US10806718, Example 72::US11491140, Example 72::US11634416, Example 72 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 14.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279042&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273372 378160630 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954727 CCOc1ncccc1-c1cc(NCc2ccncn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H25N7O/c1-5-30-22-17(7-6-9-24-22)18-11-19(25-12-16-8-10-23-13-26-16)21-20(27-18)15(4)28-29(21)14(2)3/h6-11,13-14H,5,12H2,1-4H3,(H,25,27) UIVWJGFOIVSSOG-UHFFFAOYSA-N 279043 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(pyrimidin-4-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 73::US10512632, Example 73::US10766893, Example S73::US10806718, Example 73::US11491140, Example 73::US11634416, Example 73 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 81.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279043&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273379 378160631 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954730 CCOc1ncccc1-c1cc(NCc2ncccn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H25N7O/c1-5-30-22-16(8-6-9-25-22)17-12-18(26-13-19-23-10-7-11-24-19)21-20(27-17)15(4)28-29(21)14(2)3/h6-12,14H,5,13H2,1-4H3,(H,26,27) DFFZMDINLLNNPV-UHFFFAOYSA-N 279044 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(pyrimidin-2-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 74::US10512632, Example 74::US10766893, Example S74::US10806718, Example 74::US11491140, Example 74::US11634416, Example 74 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.10 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279044&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273368 378160632 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954733 COc1ncccc1-c1cc(NCc2nccc(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H25N7O/c1-13(2)29-21-18(25-12-19-23-10-8-14(3)26-19)11-17(27-20(21)15(4)28-29)16-7-6-9-24-22(16)30-5/h6-11,13H,12H2,1-5H3,(H,25,27) DHKCBVLJHGLBIR-UHFFFAOYSA-N 462361 US10766893, Example S75 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 9.90 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=462361 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=462361&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 155903599 441293563 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954736 CCOc1ncccc1-c1cc(NCc2cnccn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H25N7O/c1-5-30-22-17(7-6-8-25-22)18-11-19(26-13-16-12-23-9-10-24-16)21-20(27-18)15(4)28-29(21)14(2)3/h6-12,14H,5,13H2,1-4H3,(H,26,27) DTEHKURDWHCADV-UHFFFAOYSA-N 279046 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(pyrazin-2-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 76::US10512632, Example 76::US10766893, Example S76::US10806718, Example 76::US11026923, Example 76::US11491140, Example 76::US11634416, Example 76 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 23.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279046&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273373 378160634 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954739 CCOc1ncccc1-c1cc(NCc2cccnc2C(F)(F)F)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H25F3N6O/c1-5-34-23-17(9-7-11-29-23)18-12-19(21-20(31-18)15(4)32-33(21)14(2)3)30-13-16-8-6-10-28-22(16)24(25,26)27/h6-12,14H,5,13H2,1-4H3,(H,30,31) TZBBGNNWRKPAEH-UHFFFAOYSA-N 279047 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[2-(trifluoromethyl)-3-pyridyl]methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 77::US10512632, Example 77::US10766893, Example S77::US10806718, Example 77::US11026923, Example 77::US11491140, Example 77::US11634416, Example 77 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 21.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279047&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273376 378160635 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954742 CCOc1ncccc1-c1cc(NCc2ccn(C)c(=O)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(8-7-10-25-24)19-13-20(26-14-17-9-11-29(5)21(31)12-17)23-22(27-19)16(4)28-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,26,27) IBAWDCALOOJODQ-UHFFFAOYSA-N 279048 4-[[[5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-yl]amino]methyl]-1-methyl-pyridin-2-one::US10034861, Example 78::US10512632, Example 78::US10766893, Example S78::US10806718, Example 78::US11026923, Example 78::US11491140, Example 78::US11634416, Example 78 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 27.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279048&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273377 378160636 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954745 CCNc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H28N8/c1-6-23-22-17(8-7-9-24-22)18-10-19(25-11-16-12-26-29(5)13-16)21-20(27-18)15(4)28-30(21)14(2)3/h7-10,12-14H,6,11H2,1-5H3,(H,23,24)(H,25,27) ZEUKRJZWWLBXIK-UHFFFAOYSA-N 279049 5-(2-(ethylamino)pyridin-3-yl)-1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 79::US10512632, Example 79::US10766893, Example S79::US10806718, Example 79::US11026923, Example 79::US11491140, Example 79::US11634416, Example 79 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 230 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279049&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273375 378160637 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954748 CCOc1ncccc1-c1cc(NCc2cc(OC)ccn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-19(8-7-10-26-24)20-13-21(27-14-17-12-18(31-5)9-11-25-17)23-22(28-20)16(4)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) BVKDBZHCRMPMSA-UHFFFAOYSA-N 279050 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(4-methoxy-2-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 81::US10512632, Example 81::US10766893, Example S81::US10806718, Example 81::US11026923, Example 81::US11491140, Example 81::US11634416, Example 81 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.000 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279050&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273378 378160638 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954751 CCOc1ncccc1-c1cc(NCc2cncc(OC)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O2/c1-6-32-23-17(8-7-9-25-23)18-10-19(26-12-16-11-24-13-20(27-16)31-5)22-21(28-18)15(4)29-30(22)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,26,28) OSHMEGNKNUJDSU-UHFFFAOYSA-N 279051 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(6-methoxypyrazin-2-yl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 82::US10512632, Example 82::US10766893, Example S82::US10806718, Example 82::US11026923, Example 82::US11491140, Example 82::US11634416, Example 82 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 16.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279051&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273380 378160639 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954754 CCOc1ncccc1-c1cc(NCc2ncc(F)cn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H24FN7O/c1-5-31-22-16(7-6-8-24-22)17-9-18(25-12-19-26-10-15(23)11-27-19)21-20(28-17)14(4)29-30(21)13(2)3/h6-11,13H,5,12H2,1-4H3,(H,25,28) ZIOQYWFVMVDZRK-UHFFFAOYSA-N 279052 5-(2-ethoxy-3-pyridyl)-N-[(5-fluoropyrimidin-2-yl)methyl]-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 83::US10512632, Example 83::US10766893, Example S83::US10806718, Example 83::US11026923, Example 83::US11491140, Example 83::US11634416, Example 83 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 17.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279052&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273381 378160640 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954757 CCOc1ncccc1-c1cc(NCc2cccnc2C)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O/c1-6-31-24-19(10-8-12-26-24)20-13-21(27-14-18-9-7-11-25-16(18)4)23-22(28-20)17(5)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) JOFWPJKNNJOGJF-UHFFFAOYSA-N 279053 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methyl-3-pyridyl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 84::US10512632, Example 84::US10766893, Example S84::US10806718, Example 84::US11026923, Example 84::US11491140, Example 84::US11634416, Example 84 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 19.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279053&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273382 378160641 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954760 CCOc1ncccc1-c1cc(NCc2cccnc2F)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H25FN6O/c1-5-31-23-17(9-7-11-26-23)18-12-19(27-13-16-8-6-10-25-22(16)24)21-20(28-18)15(4)29-30(21)14(2)3/h6-12,14H,5,13H2,1-4H3,(H,27,28) JJLMBZVLDAMDGO-UHFFFAOYSA-N 279054 5-(2-ethoxy-3-pyridyl)-N-[(2-fluoro-3-pyridyl)methyl]-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 85::US10512632, Example 85::US10766893, Example S85::US10806718, Example 85::US11026923, Example 85::US11491140, Example 85::US11634416, Example 85 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.40 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279054&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273384 378160642 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954763 CCOc1ncccc1-c1cc(NCc2cccnc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(10-8-12-26-24)19-13-20(27-14-17-9-7-11-25-23(17)31-5)22-21(28-19)16(4)29-30(22)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) LOZUTDKVJLMDTB-UHFFFAOYSA-N 279055 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 172::US10034861, Example 180::US10034861, Example 181::US10034861, Example 182::US10034861, Example 86::US10512632, Example 86::US10766893, Example S86::US10806718, Example 182::US11026923, Example 182::US11491140, Example 86::US11634416, Example 86 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 20.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279055&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273386 378160643 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954766 CCOc1ncccc1-c1cc(NCc2ccc(C)nc2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O/c1-6-31-24-19(8-7-11-25-24)20-12-21(27-14-18-10-9-16(4)26-13-18)23-22(28-20)17(5)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) VEZPCNBBBMUATR-UHFFFAOYSA-N 279056 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(6-methyl-3-pyridyl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 87::US10512632, Example 87::US10766893, Example S87::US10806718, Example 87::US11026923, Example 87::US11491140, Example 87::US11634416, Example 87 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 6.30 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279056 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279056&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273383 378160644 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954769 CCOc1ncccc1-c1cc(NCc2ccccc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C25H29N5O2/c1-6-32-25-19(11-9-13-26-25)20-14-21(27-15-18-10-7-8-12-22(18)31-5)24-23(28-20)17(4)29-30(24)16(2)3/h7-14,16H,6,15H2,1-5H3,(H,27,28) IXQRCVAKBIMUJN-UHFFFAOYSA-N 279057 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxyphenyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 88::US10512632, Example 88::US10766893, Example S88::US10806718, Example 88::US11026923, Example 88::US11491140, Example 88::US11634416, Example 88 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 110 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279057&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273385 378160645 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954772 CCOc1ncccc1-c1cc(NCc2ccccc2F)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H26FN5O/c1-5-31-24-18(10-8-12-26-24)20-13-21(27-14-17-9-6-7-11-19(17)25)23-22(28-20)16(4)29-30(23)15(2)3/h6-13,15H,5,14H2,1-4H3,(H,27,28) PBVAXRZBSWSQNU-UHFFFAOYSA-N 279058 5-(2-ethoxy-3-pyridyl)-N-[(2-fluorophenyl)methyl]-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 89::US10512632, Example 89::US10766893, Example S89::US10806718, Example 89::US11026923, Example 89::US11491140, Example 89::US11634416, Example 89 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 61.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279058&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273388 378160646 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954775 CCOc1ncccc1-c1cc(NCc2ccccc2C(F)(F)F)c2n(nc(C)c2n1)C(C)C InChI=1S/C25H26F3N5O/c1-5-34-24-18(10-8-12-29-24)20-13-21(23-22(31-20)16(4)32-33(23)15(2)3)30-14-17-9-6-7-11-19(17)25(26,27)28/h6-13,15H,5,14H2,1-4H3,(H,30,31) XUHWSBHEGYQEDI-UHFFFAOYSA-N 279059 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[2-(trifluoromethyl)phenyl]methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 90::US10512632, Example 90::US10766893, Example S90::US10806718, Example 90::US11026923, Example 90::US11491140, Example 90::US11634416, Example 90 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 270 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279059&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273387 378160647 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954778 CCOc1ncccc1-c1cc(NCc2nccnc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O2/c1-6-32-22-16(8-7-9-25-22)17-12-18(27-13-19-23(31-5)26-11-10-24-19)21-20(28-17)15(4)29-30(21)14(2)3/h7-12,14H,6,13H2,1-5H3,(H,27,28) GJZNHSHBNVLOAO-UHFFFAOYSA-N 279060 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(3-methoxypyrazin-2-yl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 91::US10512632, Example 91::US10766893, Example S91::US10806718, Example 91::US11026923, Example 91::US11491140, Example 91::US11634416, Example 91 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 27.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279060&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273389 378160648 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954781 CCOc1ncccc1-c1cc(NCc2cnccc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(8-7-10-26-24)19-12-20(27-14-17-13-25-11-9-21(17)31-5)23-22(28-19)16(4)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) BHINMZMKXRIBEG-UHFFFAOYSA-N 279061 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(4-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 92::US10512632, Example 92::US10766893, Example S92::US10806718, Example 92::US11026923, Example 92::US11491140, Example 92::US11634416, Example 92 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 47.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279061&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273390 378160649 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954784 CCCOc1ncccc1-c1cc(NCc2nnn(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H27N9O/c1-6-10-31-21-15(8-7-9-22-21)16-11-17(23-12-18-25-28-29(5)27-18)20-19(24-16)14(4)26-30(20)13(2)3/h7-9,11,13H,6,10,12H2,1-5H3,(H,23,24) IEZRRRCALKIRBN-UHFFFAOYSA-N 279062 1-isopropyl-3-methyl-N-[(2-methyltetrazol-5-yl)methyl]-5-(2-propoxy-3-pyridyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 93::US10512632, Example 93::US10766893, Example S93::US10806718, Example 93::US11026923, Example 93::US11491140, Example 93::US11634416, Example 93 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4.30 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279062&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273393 378160650 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954787 CCCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H29N7O/c1-6-10-31-23-18(8-7-9-24-23)19-11-20(25-12-17-13-26-29(5)14-17)22-21(27-19)16(4)28-30(22)15(2)3/h7-9,11,13-15H,6,10,12H2,1-5H3,(H,25,27) JYRPZCKZXZYAOY-UHFFFAOYSA-N 279063 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-(2-propoxy-3-pyridyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 94::US10512632, Example 94::US10766893, Example S94::US10806718, Example 94::US11026923, Example 94::US11491140, Example 94::US11634416, Example 94 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.40 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279063&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273391 378160651 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954790 COc1ncccc1CNc1cc(nc2c(C)nn(C(C)C)c12)-c1cccnc1OC InChI=1S/C23H26N6O2/c1-14(2)29-21-19(26-13-16-8-6-10-24-22(16)30-4)12-18(27-20(21)15(3)28-29)17-9-7-11-25-23(17)31-5/h6-12,14H,13H2,1-5H3,(H,26,27) YPNDBZHHIYJRNN-UHFFFAOYSA-N 279064 1-isopropyl-5-(2-methoxy-3-pyridyl)-N-[(2-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 95::US10512632, Example 95::US10766893, Example S95::US10806718, Example 95::US11026923, Example 95::US11491140, Example 95::US11634416, Example 95 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 42.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279064 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279064&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273392 378160652 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954793 COc1ccc(CNc2cc(nc3c(C)nn(C(C)C)c23)-c2cccnc2OC)cn1 InChI=1S/C23H26N6O2/c1-14(2)29-22-19(25-12-16-8-9-20(30-4)26-13-16)11-18(27-21(22)15(3)28-29)17-7-6-10-24-23(17)31-5/h6-11,13-14H,12H2,1-5H3,(H,25,27) HUQJJAUBVULGLS-UHFFFAOYSA-N 279065 1-isopropyl-5-(2-methoxy-3-pyridyl)-N-[(6-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 96::US10512632, Example 96::US10766893, Example S96::US10806718, Example 96::US11026923, Example 96::US11491140, Example 96::US11634416, Example 96 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 18.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279065&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273394 378160653 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954796 CC(C)Oc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H29N7O/c1-14(2)30-22-20(25-11-17-12-26-29(6)13-17)10-19(27-21(22)16(5)28-30)18-8-7-9-24-23(18)31-15(3)4/h7-10,12-15H,11H2,1-6H3,(H,25,27) IWDHUHWZRSHWGD-UHFFFAOYSA-N 279066 5-(2-isopropoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 97::US10512632, Example 97::US10766893, Example S97::US10806718, Example 97::US11026923, Example 97::US11491140, Example 97::US11634416, Example 97 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.40 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279066&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273395 378160654 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954799 CCOc1ncccc1-c1cc(NCc2nc[nH]n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C20H24N8O/c1-5-29-20-14(7-6-8-21-20)15-9-16(22-10-17-23-11-24-26-17)19-18(25-15)13(4)27-28(19)12(2)3/h6-9,11-12H,5,10H2,1-4H3,(H,22,25)(H,23,24,26) ZUZXEJWHRNAFBA-UHFFFAOYSA-N 279067 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1H-1,2,4-triazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 98::US10512632, Example 98::US10766893, Example S98::US10806718, Example 98::US11491140, Example 98::US11634416, Example 98 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 7.20 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279067 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279067&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273396 378160655 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954802 CCOc1ncccc1-c1cc(NCc2nn[nH]n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C19H23N9O/c1-5-29-19-13(7-6-8-20-19)14-9-15(21-10-16-23-26-27-24-16)18-17(22-14)12(4)25-28(18)11(2)3/h6-9,11H,5,10H2,1-4H3,(H,21,22)(H,23,24,26,27) DBRGOFPEANLZGU-UHFFFAOYSA-N 279068 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(2H-tetrazol-5-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 99::US10512632, Example 99::US10766893, Example S99::US10806718, Example 99::US11026923, Example 99::US11491140, Example 99::US11634416, Example 99 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.730 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279068&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273399 378160656 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954805 CCOc1ncccc1-c1cc(NCc2ccccn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H26N6O/c1-5-30-23-18(10-8-12-25-23)19-13-20(26-14-17-9-6-7-11-24-17)22-21(27-19)16(4)28-29(22)15(2)3/h6-13,15H,5,14H2,1-4H3,(H,26,27) GWMDZOSIIBARTA-UHFFFAOYSA-N 279069 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(2-pyridylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 100::US10512632, Example 100::US10766893, Example S100::US10806718, Example 100::US11026923, Example 100::US11491140, Example 100::US11634416, Example 100 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 6.30 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279069&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273397 378160657 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954808 CCOc1ncccc1-c1cc(NCc2cccc(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O/c1-6-31-24-19(11-8-12-25-24)20-13-21(26-14-18-10-7-9-16(4)27-18)23-22(28-20)17(5)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,26,28) HBRGVUVPCCNRAT-UHFFFAOYSA-N 279070 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(6-methyl-2-pyridyl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 101::US10512632, Example 101::US10766893, Example S101::US10806718, Example 101::US11026923, Example 101::US11491140, Example 101::US11634416, Example 101 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 20.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279070&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273398 378160658 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954811 CCOc1ncccc1-c1cc(NCc2cccc(OC)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(10-8-12-25-24)19-13-20(26-14-17-9-7-11-21(27-17)31-5)23-22(28-19)16(4)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,26,28) DHUHVCYRBUZRAT-UHFFFAOYSA-N 279071 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(6-methoxy-2-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 102::US10512632, Example 102::US10766893, Example S102::US10806718, Example 102::US11026923, Example 102::US11491140, Example 102::US11634416, Example 102 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.00 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279071&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273400 378160659 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954814 CCOc1ncccc1-c1cc(NCc2ccnc(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O/c1-6-31-24-19(8-7-10-26-24)20-13-21(27-14-18-9-11-25-16(4)12-18)23-22(28-20)17(5)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) MPJXQIBFZBPJFH-UHFFFAOYSA-N 279072 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methyl-4-pyridyl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 103::US10512632, Example 103::US10766893, Example S103::US10806718, Example 103::US11026923, Example 103::US11491140, Example 103::US11634416, Example 103 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 5.40 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279072&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273402 378160660 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954817 CCOc1ncccc1-c1cc(NCc2ccnc(OC)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(8-7-10-26-24)19-13-20(27-14-17-9-11-25-21(12-17)31-5)23-22(28-19)16(4)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) SJJQCULDRYOYED-UHFFFAOYSA-N 279073 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-4-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 104::US10512632, Example 104::US10766893, Example S104::US10806718, Example 104::US11026923, Example 104::US11491140, Example 104::US11634416, Example 104 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.20 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279073&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273401 378160661 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954820 CCOc1ncccc1-c1cc(NCc2ccnc(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O/c1-6-31-23-18(8-7-10-25-23)19-12-20(26-13-17-9-11-24-16(5)27-17)22-21(28-19)15(4)29-30(22)14(2)3/h7-12,14H,6,13H2,1-5H3,(H,26,28) OEGPBHHKEYGZCG-UHFFFAOYSA-N 279074 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methylpyrimidin-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 105::US10512632, Example 105::US10766893, Example S105::US10806718, Example 105::US11026923, Example 105::US11491140, Example 105::US11634416, Example 105 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 54.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279074&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273403 378160662 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954823 CCOc1ncccc1-c1cc(NCc2cncc(OC)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-19(8-7-9-26-24)20-11-21(27-13-17-10-18(31-5)14-25-12-17)23-22(28-20)16(4)29-30(23)15(2)3/h7-12,14-15H,6,13H2,1-5H3,(H,27,28) JCOKQWFPIMEUNS-UHFFFAOYSA-N 279075 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(5-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 106::US10512632, Example 106::US10766893, Example S106::US10806718, Example 106::US11026923, Example 106::US11491140, Example 106::US11634416, Example 106 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.10 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279075&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273404 378160663 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954826 CCOc1ncccc1-c1cc(NCc2cccc(n2)C(F)(F)F)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H25F3N6O/c1-5-34-23-17(9-7-11-28-23)18-12-19(22-21(31-18)15(4)32-33(22)14(2)3)29-13-16-8-6-10-20(30-16)24(25,26)27/h6-12,14H,5,13H2,1-4H3,(H,29,31) FVVVRFIRYVUVEI-UHFFFAOYSA-N 279076 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[6-(trifluoromethyl)-2-pyridyl]methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 107::US10512632, Example 107::US10766893, Example S107::US10806718, Example 107::US11026923, Example 107::US11491140, Example 107::US11634416, Example 107 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 110 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279076&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273405 378160664 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954829 CCOc1ncccc1-c1cc(NCc2cccn(C)c2=O)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-23-18(10-7-11-25-23)19-13-20(26-14-17-9-8-12-29(5)24(17)31)22-21(27-19)16(4)28-30(22)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,26,27) YLQLMBPUXKUVLD-UHFFFAOYSA-N 279077 3-[[[5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-yl]amino]methyl]-1-methyl-pyridin-2-one::US10034861, Example 108::US10512632, Example 108::US10766893, Example S108::US10806718, Example 108::US11026923, Example 108::US11491140, Example 108::US11634416, Example 108 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.80 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279077&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273406 378160665 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954832 CCOc1ncccc1-c1cc(NCc2cnn(CC)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H29N7O/c1-6-29-14-17(13-26-29)12-25-20-11-19(18-9-8-10-24-23(18)31-7-2)27-21-16(5)28-30(15(3)4)22(20)21/h8-11,13-15H,6-7,12H2,1-5H3,(H,25,27) IEORIQPBXNSJCP-UHFFFAOYSA-N 279078 5-(2-ethoxy-3-pyridyl)-N-[(1-ethylpyrazol-4-yl)methyl]-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 109::US10512632, Example 109::US10766893, Example S109::US10806718, Example 109::US11026923, Example 109::US11491140, Example 109::US11634416, Example 109 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4.90 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279078&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273407 378160666 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954835 CCCn1cc(CNc2cc(nc3c(C)nn(C(C)C)c23)-c2cccnc2OCC)cn1 InChI=1S/C24H31N7O/c1-6-11-30-15-18(14-27-30)13-26-21-12-20(19-9-8-10-25-24(19)32-7-2)28-22-17(5)29-31(16(3)4)23(21)22/h8-10,12,14-16H,6-7,11,13H2,1-5H3,(H,26,28) NPLKFZSTTQLUHS-UHFFFAOYSA-N 279079 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(1-propylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 110::US10512632, Example 110::US10766893, Example S110::US10806718, Example 110::US11026923, Example 110::US11491140, Example 110::US11634416, Example 110 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 11.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279079&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273408 378160667 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954838 CCOc1ncccc1-c1cc(NCc2ccc(OC)nc2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(8-7-11-25-24)19-12-20(26-13-17-9-10-21(31-5)27-14-17)23-22(28-19)16(4)29-30(23)15(2)3/h7-12,14-15H,6,13H2,1-5H3,(H,26,28) XMJAAWKICASNAA-UHFFFAOYSA-N 279080 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(6-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 111::US10512632, Example 111::US10766893, Example S111::US10806718, Example 111::US11026923, Example 111::US11491140, Example 111::US11634416, Example 111 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 28.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279080 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279080&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273409 378160668 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954841 CCOc1ncccc1-c1cc(NCc2ccc(OC)cn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-19(8-7-11-25-24)20-12-21(27-13-17-9-10-18(31-5)14-26-17)23-22(28-20)16(4)29-30(23)15(2)3/h7-12,14-15H,6,13H2,1-5H3,(H,27,28) HWSJSACIWPNYOB-UHFFFAOYSA-N 279081 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(5-methoxy-2-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 112::US10512632, Example 112::US10766893, Example S112::US10806718, Example 112::US11026923, Example 112::US11491140, Example 112::US11634416, Example 112 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 61.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279081&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273411 378160669 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954844 CCOc1ncccc1-c1cc(NCc2csc(C)n2)c2n(nc(C)c2n1)C1COC1 InChI=1S/C22H24N6O2S/c1-4-30-22-17(6-5-7-23-22)18-8-19(24-9-15-12-31-14(3)25-15)21-20(26-18)13(2)27-28(21)16-10-29-11-16/h5-8,12,16H,4,9-11H2,1-3H3,(H,24,26) BSSGJYYHYVLYMA-UHFFFAOYSA-N 279082 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(2-methylthiazol-4-yl)methyl]-1-(oxetan-3-yl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 113::US10512632, Example 113::US10618913, Example S113::US10766893, Example S113::US10806718, Example 113::US11026923, Example 113::US11491140, Example 113::US11634416, Example 113 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 110 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279082&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273410 378160670 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954847 CCOc1ncccc1-c1cc(NCc2cnc(OC)cn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O2/c1-6-32-23-17(8-7-9-24-23)18-10-19(26-11-16-12-27-20(31-5)13-25-16)22-21(28-18)15(4)29-30(22)14(2)3/h7-10,12-14H,6,11H2,1-5H3,(H,26,28) QIWVSVNHRDQBOW-UHFFFAOYSA-N 279083 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(5-methoxypyrazin-2-yl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 114::US10512632, Example 114::US10766893, Example S114::US10806718, Example 114::US11026923, Example 114::US11491140, Example 114::US11634416, Example 114 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 24.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279083 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279083&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273413 378160671 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954850 CCOc1ncccc1-c1cc(NCc2cccnc2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H26N6O/c1-5-30-23-18(9-7-11-25-23)19-12-20(26-14-17-8-6-10-24-13-17)22-21(27-19)16(4)28-29(22)15(2)3/h6-13,15H,5,14H2,1-4H3,(H,26,27) MYYHBCJMEYIHMC-UHFFFAOYSA-N 279084 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(3-pyridylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 115::US10512632, Example 115::US10766893, Example S115::US10806718, Example 115::US11026923, Example 115::US11491140, Example 115::US11634416, Example 115 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 15.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279084&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273412 378160672 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954853 CCOc1ncccc1-c1cc(NCc2ccc(F)nc2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H25FN6O/c1-5-31-23-17(7-6-10-25-23)18-11-19(26-12-16-8-9-20(24)27-13-16)22-21(28-18)15(4)29-30(22)14(2)3/h6-11,13-14H,5,12H2,1-4H3,(H,26,28) SKXWAYULKGVUDE-UHFFFAOYSA-N 279085 5-(2-ethoxy-3-pyridyl)-N-[(6-fluoro-3-pyridyl)methyl]-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 116::US10512632, Example 116::US10766893, Example S116::US10806718, Example 116::US11026923, Example 116::US11491140, Example 116::US11634416, Example 116 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 21.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279085&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273414 378160673 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954856 CCOc1ncccc1-c1cc(NCc2ccc(nc2)C(F)F)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H26F2N6O/c1-5-33-24-17(7-6-10-27-24)19-11-20(22-21(30-19)15(4)31-32(22)14(2)3)29-13-16-8-9-18(23(25)26)28-12-16/h6-12,14,23H,5,13H2,1-4H3,(H,29,30) FDEJYPFAUDLEJD-UHFFFAOYSA-N 279086 N-[[6-(difluoromethyl)-3-pyridyl]methyl]-5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 117::US10512632, Example 117::US10766893, Example S117::US10806718, Example 117::US11026923, Example 117::US11491140, Example 117::US11634416, Example 117 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 18.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279086&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273416 378160674 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954859 CCOc1ncccc1-c1cc(NCc2ncccc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-17(9-7-12-26-24)18-13-19(27-14-20-21(31-5)10-8-11-25-20)23-22(28-18)16(4)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) CQZGCHPJVLXYPV-UHFFFAOYSA-N 279087 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(3-methoxy-2-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 118::US10512632, Example 118::US10766893, Example S118::US10806718, Example 118::US11026923, Example 118::US11491140, Example 118::US11634416, Example 118 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 13.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279087&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273417 378160675 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954862 CCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(nc(C)c2n1)C(C)CC 279088 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 119::US10034861, Example 120::US10512632, Example 120::US10618913, Example S120::US10766893, Example S120::US10806718, Example 120::US11026923, Example 120::US11634416, Example 120 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 12.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279088&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273415 378160676 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954865 CCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(nc(C)c2n1)C(C)CC 279088 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 119::US10034861, Example 120::US10512632, Example 120::US10618913, Example S120::US10766893, Example S120::US10806718, Example 120::US11026923, Example 120::US11634416, Example 120 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4.60 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279088&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273415 378160676 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954868 CCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C22H28N8O/c1-6-14(3)30-21-18(24-12-19-25-13-29(5)28-19)11-17(26-20(21)15(4)27-30)16-9-8-10-23-22(16)31-7-2/h8-11,13-14H,6-7,12H2,1-5H3,(H,24,26) RANZHWURGHEKDD-UHFFFAOYSA-N 279090 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 121::US10034861, Example 122::US10512632, Example 122::US10766893, Example S122::US10806718, Example 122::US11634416, Example 122 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4.00 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279090&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273418 378160677 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954871 CCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C22H28N8O/c1-6-14(3)30-21-18(24-12-19-25-13-29(5)28-19)11-17(26-20(21)15(4)27-30)16-9-8-10-23-22(16)31-7-2/h8-11,13-14H,6-7,12H2,1-5H3,(H,24,26) RANZHWURGHEKDD-UHFFFAOYSA-N 279090 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 121::US10034861, Example 122::US10512632, Example 122::US10766893, Example S122::US10806718, Example 122::US11634416, Example 122 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.20 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279090&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273418 378160677 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954874 CCOc1ncccc1-c1cc(NCc2nnc(C)o2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C22H27N7O2/c1-6-13(3)29-21-18(24-12-19-27-26-15(5)31-19)11-17(25-20(21)14(4)28-29)16-9-8-10-23-22(16)30-7-2/h8-11,13H,6-7,12H2,1-5H3,(H,24,25) SJDHGTJKQKPRAR-UHFFFAOYSA-N 279092 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(5-methyl-1,3,4-oxadiazol-2-yl)methyl]-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 123::US10034861, Example 124::US10512632, Example 123::US10766893, Example S124::US10806718, Example 124::US11634416, Example 124 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 54.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279092&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273419 378160678 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954877 CCOc1ncccc1-c1cc(NCc2nnc(C)o2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C22H27N7O2/c1-6-13(3)29-21-18(24-12-19-27-26-15(5)31-19)11-17(25-20(21)14(4)28-29)16-9-8-10-23-22(16)30-7-2/h8-11,13H,6-7,12H2,1-5H3,(H,24,25) SJDHGTJKQKPRAR-UHFFFAOYSA-N 279092 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(5-methyl-1,3,4-oxadiazol-2-yl)methyl]-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 123::US10034861, Example 124::US10512632, Example 123::US10766893, Example S124::US10806718, Example 124::US11634416, Example 124 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 9.70 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279092&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273419 378160678 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954880 CCOc1ncccc1-c1cc(NCc2cncc(OC)c2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C25H30N6O2/c1-6-16(3)31-24-22(28-14-18-11-19(32-5)15-26-13-18)12-21(29-23(24)17(4)30-31)20-9-8-10-27-25(20)33-7-2/h8-13,15-16H,6-7,14H2,1-5H3,(H,28,29) SYWOKLNWWYOPHL-UHFFFAOYSA-N 279094 5-(2-ethoxy-3-pyridyl)-N-[(5-methoxy-3-pyridyl)methyl]-3-methyl-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 125::US10512632, Example 125::US10766893, Example S125::US10806718, Example 125::US11634416, Example 125 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.000 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279094&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273422 378160679 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954883 CCOc1ncccc1-c1cc(NCc2ccnc(OC)c2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C25H30N6O2/c1-6-16(3)31-24-21(28-15-18-10-12-26-22(13-18)32-5)14-20(29-23(24)17(4)30-31)19-9-8-11-27-25(19)33-7-2/h8-14,16H,6-7,15H2,1-5H3,(H,28,29) JRNBIFGQRNWOKC-UHFFFAOYSA-N 279095 5-(2-ethoxy-3-pyridyl)-N-[(2-methoxy-4-pyridyl)methyl]-3-methyl-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 126::US10512632, Example 126::US10766893, Example S126::US10806718, Example 126::US11634416, Example 126 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 5.40 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279095&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273420 378160680 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954886 CCOc1ncccc1-c1cc(NCc2nnn(C)n2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C21H27N9O/c1-6-13(3)30-20-17(23-12-18-25-28-29(5)27-18)11-16(24-19(20)14(4)26-30)15-9-8-10-22-21(15)31-7-2/h8-11,13H,6-7,12H2,1-5H3,(H,23,24) ULBLNKNNIPTFLN-UHFFFAOYSA-N 279096 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]-N-[(2-methyltetrazol-5-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 127::US10512632, Example 127::US10766893, Example S127::US10806718, Example 127::US11634416, Example 127 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.80 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279096&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273421 378160681 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954889 CCOc1ncccc1-c1cc(NCc2noc(C)n2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C22H27N7O2/c1-6-13(3)29-21-18(24-12-19-25-15(5)31-28-19)11-17(26-20(21)14(4)27-29)16-9-8-10-23-22(16)30-7-2/h8-11,13H,6-7,12H2,1-5H3,(H,24,26) XOIXJVILDWTHEL-UHFFFAOYSA-N 279097 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 128::US10512632, Example 128::US10766893, Example S128::US10806718, Example 128::US11634416, Example 128 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.20 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279097 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279097&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273425 378160682 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954892 CCOc1ncccc1-c1cc(NCc2coc(C)n2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C23H28N6O2/c1-6-14(3)29-22-20(25-12-17-13-31-16(5)26-17)11-19(27-21(22)15(4)28-29)18-9-8-10-24-23(18)30-7-2/h8-11,13-14H,6-7,12H2,1-5H3,(H,25,27) NAPUFLNYEBBQPU-UHFFFAOYSA-N 279098 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(2-methyloxazol-4-yl)methyl]-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 129::US10512632, Example 129::US10766893, Example S129::US10806718, Example 129::US11634416, Example 129 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 11.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279098 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279098&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273423 378160683 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 954895 CCOc1ncccc1-c1cc(NCc2c[nH]cn2)c2n(nc(C)c2n1)C(C)CC 279099 5-(2-ethoxy-3-pyridyl)-N-(1H-imidazol-4-ylmethyl)-3-methyl-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 130::US10512632, Example 130::US10766893, Example S130::US10806718, Example 130::US11634416, Example 130 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 11.0 US Patent 10.7270/Q2ZP495P aid1804802 US10766893 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279099&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273424 378160684 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967372 CCNc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H28N8/c1-6-23-22-17(8-7-9-24-22)18-10-19(25-11-16-12-26-29(5)13-16)21-20(27-18)15(4)28-30(21)14(2)3/h7-10,12-14H,6,11H2,1-5H3,(H,23,24)(H,25,27) ZEUKRJZWWLBXIK-UHFFFAOYSA-N 279049 5-(2-(ethylamino)pyridin-3-yl)-1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 79::US10512632, Example 79::US10766893, Example S79::US10806718, Example 79::US11026923, Example 79::US11491140, Example 79::US11634416, Example 79 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 230 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279049&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273375 378160637 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967375 CCOc1ncccc1-c1cc(NCc2cc(OC)ccn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-19(8-7-10-26-24)20-13-21(27-14-17-12-18(31-5)9-11-25-17)23-22(28-20)16(4)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) BVKDBZHCRMPMSA-UHFFFAOYSA-N 279050 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(4-methoxy-2-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 81::US10512632, Example 81::US10766893, Example S81::US10806718, Example 81::US11026923, Example 81::US11491140, Example 81::US11634416, Example 81 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.000 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279050&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273378 378160638 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967378 CCOc1ncccc1-c1cc(NCc2cncc(OC)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O2/c1-6-32-23-17(8-7-9-25-23)18-10-19(26-12-16-11-24-13-20(27-16)31-5)22-21(28-18)15(4)29-30(22)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,26,28) OSHMEGNKNUJDSU-UHFFFAOYSA-N 279051 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(6-methoxypyrazin-2-yl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 82::US10512632, Example 82::US10766893, Example S82::US10806718, Example 82::US11026923, Example 82::US11491140, Example 82::US11634416, Example 82 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 16.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279051&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273380 378160639 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967381 CCOc1ncccc1-c1cc(NCc2ncc(F)cn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H24FN7O/c1-5-31-22-16(7-6-8-24-22)17-9-18(25-12-19-26-10-15(23)11-27-19)21-20(28-17)14(4)29-30(21)13(2)3/h6-11,13H,5,12H2,1-4H3,(H,25,28) ZIOQYWFVMVDZRK-UHFFFAOYSA-N 279052 5-(2-ethoxy-3-pyridyl)-N-[(5-fluoropyrimidin-2-yl)methyl]-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 83::US10512632, Example 83::US10766893, Example S83::US10806718, Example 83::US11026923, Example 83::US11491140, Example 83::US11634416, Example 83 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 17.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279052&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273381 378160640 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967384 CCOc1ncccc1-c1cc(NCc2cccnc2C)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O/c1-6-31-24-19(10-8-12-26-24)20-13-21(27-14-18-9-7-11-25-16(18)4)23-22(28-20)17(5)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) JOFWPJKNNJOGJF-UHFFFAOYSA-N 279053 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methyl-3-pyridyl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 84::US10512632, Example 84::US10766893, Example S84::US10806718, Example 84::US11026923, Example 84::US11491140, Example 84::US11634416, Example 84 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 19.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279053&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273382 378160641 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967387 CCOc1ncccc1-c1cc(NCc2cccnc2F)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H25FN6O/c1-5-31-23-17(9-7-11-26-23)18-12-19(27-13-16-8-6-10-25-22(16)24)21-20(28-18)15(4)29-30(21)14(2)3/h6-12,14H,5,13H2,1-4H3,(H,27,28) JJLMBZVLDAMDGO-UHFFFAOYSA-N 279054 5-(2-ethoxy-3-pyridyl)-N-[(2-fluoro-3-pyridyl)methyl]-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 85::US10512632, Example 85::US10766893, Example S85::US10806718, Example 85::US11026923, Example 85::US11491140, Example 85::US11634416, Example 85 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.40 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279054&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273384 378160642 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967390 CCOc1ncccc1-c1cc(NCc2cccnc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(10-8-12-26-24)19-13-20(27-14-17-9-7-11-25-23(17)31-5)22-21(28-19)16(4)29-30(22)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) LOZUTDKVJLMDTB-UHFFFAOYSA-N 279055 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 172::US10034861, Example 180::US10034861, Example 181::US10034861, Example 182::US10034861, Example 86::US10512632, Example 86::US10766893, Example S86::US10806718, Example 182::US11026923, Example 182::US11491140, Example 86::US11634416, Example 86 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 20.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279055&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273386 378160643 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967393 CCOc1ncccc1-c1cc(NCc2ccc(C)nc2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O/c1-6-31-24-19(8-7-11-25-24)20-12-21(27-14-18-10-9-16(4)26-13-18)23-22(28-20)17(5)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) VEZPCNBBBMUATR-UHFFFAOYSA-N 279056 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(6-methyl-3-pyridyl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 87::US10512632, Example 87::US10766893, Example S87::US10806718, Example 87::US11026923, Example 87::US11491140, Example 87::US11634416, Example 87 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 6.30 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279056 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279056&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273383 378160644 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967396 CCOc1ncccc1-c1cc(NCc2ccccc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C25H29N5O2/c1-6-32-25-19(11-9-13-26-25)20-14-21(27-15-18-10-7-8-12-22(18)31-5)24-23(28-20)17(4)29-30(24)16(2)3/h7-14,16H,6,15H2,1-5H3,(H,27,28) IXQRCVAKBIMUJN-UHFFFAOYSA-N 279057 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxyphenyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 88::US10512632, Example 88::US10766893, Example S88::US10806718, Example 88::US11026923, Example 88::US11491140, Example 88::US11634416, Example 88 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 110 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279057&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273385 378160645 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967399 CCOc1ncccc1-c1cc(NCc2ccccc2F)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H26FN5O/c1-5-31-24-18(10-8-12-26-24)20-13-21(27-14-17-9-6-7-11-19(17)25)23-22(28-20)16(4)29-30(23)15(2)3/h6-13,15H,5,14H2,1-4H3,(H,27,28) PBVAXRZBSWSQNU-UHFFFAOYSA-N 279058 5-(2-ethoxy-3-pyridyl)-N-[(2-fluorophenyl)methyl]-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 89::US10512632, Example 89::US10766893, Example S89::US10806718, Example 89::US11026923, Example 89::US11491140, Example 89::US11634416, Example 89 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 61.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279058&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273388 378160646 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967402 CCOc1ncccc1-c1cc(NCc2ccccc2C(F)(F)F)c2n(nc(C)c2n1)C(C)C InChI=1S/C25H26F3N5O/c1-5-34-24-18(10-8-12-29-24)20-13-21(23-22(31-20)16(4)32-33(23)15(2)3)30-14-17-9-6-7-11-19(17)25(26,27)28/h6-13,15H,5,14H2,1-4H3,(H,30,31) XUHWSBHEGYQEDI-UHFFFAOYSA-N 279059 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[2-(trifluoromethyl)phenyl]methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 90::US10512632, Example 90::US10766893, Example S90::US10806718, Example 90::US11026923, Example 90::US11491140, Example 90::US11634416, Example 90 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 270 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279059&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273387 378160647 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967405 CCOc1ncccc1-c1cc(NCc2nccnc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O2/c1-6-32-22-16(8-7-9-25-22)17-12-18(27-13-19-23(31-5)26-11-10-24-19)21-20(28-17)15(4)29-30(21)14(2)3/h7-12,14H,6,13H2,1-5H3,(H,27,28) GJZNHSHBNVLOAO-UHFFFAOYSA-N 279060 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(3-methoxypyrazin-2-yl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 91::US10512632, Example 91::US10766893, Example S91::US10806718, Example 91::US11026923, Example 91::US11491140, Example 91::US11634416, Example 91 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 27.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279060&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273389 378160648 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967408 CCOc1ncccc1-c1cc(NCc2cnccc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(8-7-10-26-24)19-12-20(27-14-17-13-25-11-9-21(17)31-5)23-22(28-19)16(4)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) BHINMZMKXRIBEG-UHFFFAOYSA-N 279061 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(4-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 92::US10512632, Example 92::US10766893, Example S92::US10806718, Example 92::US11026923, Example 92::US11491140, Example 92::US11634416, Example 92 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 47.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279061&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273390 378160649 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967411 CCCOc1ncccc1-c1cc(NCc2nnn(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H27N9O/c1-6-10-31-21-15(8-7-9-22-21)16-11-17(23-12-18-25-28-29(5)27-18)20-19(24-16)14(4)26-30(20)13(2)3/h7-9,11,13H,6,10,12H2,1-5H3,(H,23,24) IEZRRRCALKIRBN-UHFFFAOYSA-N 279062 1-isopropyl-3-methyl-N-[(2-methyltetrazol-5-yl)methyl]-5-(2-propoxy-3-pyridyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 93::US10512632, Example 93::US10766893, Example S93::US10806718, Example 93::US11026923, Example 93::US11491140, Example 93::US11634416, Example 93 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4.30 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279062&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273393 378160650 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967414 CCCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H29N7O/c1-6-10-31-23-18(8-7-9-24-23)19-11-20(25-12-17-13-26-29(5)14-17)22-21(27-19)16(4)28-30(22)15(2)3/h7-9,11,13-15H,6,10,12H2,1-5H3,(H,25,27) JYRPZCKZXZYAOY-UHFFFAOYSA-N 279063 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-(2-propoxy-3-pyridyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 94::US10512632, Example 94::US10766893, Example S94::US10806718, Example 94::US11026923, Example 94::US11491140, Example 94::US11634416, Example 94 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.40 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279063&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273391 378160651 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967417 COc1ncccc1CNc1cc(nc2c(C)nn(C(C)C)c12)-c1cccnc1OC InChI=1S/C23H26N6O2/c1-14(2)29-21-19(26-13-16-8-6-10-24-22(16)30-4)12-18(27-20(21)15(3)28-29)17-9-7-11-25-23(17)31-5/h6-12,14H,13H2,1-5H3,(H,26,27) YPNDBZHHIYJRNN-UHFFFAOYSA-N 279064 1-isopropyl-5-(2-methoxy-3-pyridyl)-N-[(2-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 95::US10512632, Example 95::US10766893, Example S95::US10806718, Example 95::US11026923, Example 95::US11491140, Example 95::US11634416, Example 95 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 42.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279064 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279064&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273392 378160652 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967420 COc1ccc(CNc2cc(nc3c(C)nn(C(C)C)c23)-c2cccnc2OC)cn1 InChI=1S/C23H26N6O2/c1-14(2)29-22-19(25-12-16-8-9-20(30-4)26-13-16)11-18(27-21(22)15(3)28-29)17-7-6-10-24-23(17)31-5/h6-11,13-14H,12H2,1-5H3,(H,25,27) HUQJJAUBVULGLS-UHFFFAOYSA-N 279065 1-isopropyl-5-(2-methoxy-3-pyridyl)-N-[(6-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 96::US10512632, Example 96::US10766893, Example S96::US10806718, Example 96::US11026923, Example 96::US11491140, Example 96::US11634416, Example 96 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 18.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279065&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273394 378160653 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967423 CC(C)Oc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H29N7O/c1-14(2)30-22-20(25-11-17-12-26-29(6)13-17)10-19(27-21(22)16(5)28-30)18-8-7-9-24-23(18)31-15(3)4/h7-10,12-15H,11H2,1-6H3,(H,25,27) IWDHUHWZRSHWGD-UHFFFAOYSA-N 279066 5-(2-isopropoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 97::US10512632, Example 97::US10766893, Example S97::US10806718, Example 97::US11026923, Example 97::US11491140, Example 97::US11634416, Example 97 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.40 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279066&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273395 378160654 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967426 CCOc1ncccc1-c1cc(NCc2nc[nH]n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C20H24N8O/c1-5-29-20-14(7-6-8-21-20)15-9-16(22-10-17-23-11-24-26-17)19-18(25-15)13(4)27-28(19)12(2)3/h6-9,11-12H,5,10H2,1-4H3,(H,22,25)(H,23,24,26) ZUZXEJWHRNAFBA-UHFFFAOYSA-N 279067 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1H-1,2,4-triazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 98::US10512632, Example 98::US10766893, Example S98::US10806718, Example 98::US11491140, Example 98::US11634416, Example 98 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 7.20 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279067 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279067&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273396 378160655 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967429 CCOc1ncccc1-c1cc(NCc2nn[nH]n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C19H23N9O/c1-5-29-19-13(7-6-8-20-19)14-9-15(21-10-16-23-26-27-24-16)18-17(22-14)12(4)25-28(18)11(2)3/h6-9,11H,5,10H2,1-4H3,(H,21,22)(H,23,24,26,27) DBRGOFPEANLZGU-UHFFFAOYSA-N 279068 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(2H-tetrazol-5-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 99::US10512632, Example 99::US10766893, Example S99::US10806718, Example 99::US11026923, Example 99::US11491140, Example 99::US11634416, Example 99 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.730 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279068&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273399 378160656 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967432 CCOc1ncccc1-c1cc(NCc2ccccn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H26N6O/c1-5-30-23-18(10-8-12-25-23)19-13-20(26-14-17-9-6-7-11-24-17)22-21(27-19)16(4)28-29(22)15(2)3/h6-13,15H,5,14H2,1-4H3,(H,26,27) GWMDZOSIIBARTA-UHFFFAOYSA-N 279069 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(2-pyridylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 100::US10512632, Example 100::US10766893, Example S100::US10806718, Example 100::US11026923, Example 100::US11491140, Example 100::US11634416, Example 100 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 6.30 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279069&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273397 378160657 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967435 CCOc1ncccc1-c1cc(NCc2cccc(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O/c1-6-31-24-19(11-8-12-25-24)20-13-21(26-14-18-10-7-9-16(4)27-18)23-22(28-20)17(5)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,26,28) HBRGVUVPCCNRAT-UHFFFAOYSA-N 279070 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(6-methyl-2-pyridyl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 101::US10512632, Example 101::US10766893, Example S101::US10806718, Example 101::US11026923, Example 101::US11491140, Example 101::US11634416, Example 101 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 20.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279070&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273398 378160658 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967438 CCOc1ncccc1-c1cc(NCc2cccc(OC)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(10-8-12-25-24)19-13-20(26-14-17-9-7-11-21(27-17)31-5)23-22(28-19)16(4)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,26,28) DHUHVCYRBUZRAT-UHFFFAOYSA-N 279071 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(6-methoxy-2-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 102::US10512632, Example 102::US10766893, Example S102::US10806718, Example 102::US11026923, Example 102::US11491140, Example 102::US11634416, Example 102 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.00 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279071&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273400 378160659 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967441 CCOc1ncccc1-c1cc(NCc2ccnc(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O/c1-6-31-24-19(8-7-10-26-24)20-13-21(27-14-18-9-11-25-16(4)12-18)23-22(28-20)17(5)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) MPJXQIBFZBPJFH-UHFFFAOYSA-N 279072 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methyl-4-pyridyl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 103::US10512632, Example 103::US10766893, Example S103::US10806718, Example 103::US11026923, Example 103::US11491140, Example 103::US11634416, Example 103 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 5.40 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279072&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273402 378160660 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967444 CCOc1ncccc1-c1cc(NCc2ccnc(OC)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(8-7-10-26-24)19-13-20(27-14-17-9-11-25-21(12-17)31-5)23-22(28-19)16(4)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) SJJQCULDRYOYED-UHFFFAOYSA-N 279073 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-4-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 104::US10512632, Example 104::US10766893, Example S104::US10806718, Example 104::US11026923, Example 104::US11491140, Example 104::US11634416, Example 104 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.20 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279073&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273401 378160661 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967447 CCOc1ncccc1-c1cc(NCc2ccnc(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O/c1-6-31-23-18(8-7-10-25-23)19-12-20(26-13-17-9-11-24-16(5)27-17)22-21(28-19)15(4)29-30(22)14(2)3/h7-12,14H,6,13H2,1-5H3,(H,26,28) OEGPBHHKEYGZCG-UHFFFAOYSA-N 279074 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methylpyrimidin-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 105::US10512632, Example 105::US10766893, Example S105::US10806718, Example 105::US11026923, Example 105::US11491140, Example 105::US11634416, Example 105 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 54.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279074&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273403 378160662 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967450 CCOc1ncccc1-c1cc(NCc2cncc(OC)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-19(8-7-9-26-24)20-11-21(27-13-17-10-18(31-5)14-25-12-17)23-22(28-20)16(4)29-30(23)15(2)3/h7-12,14-15H,6,13H2,1-5H3,(H,27,28) JCOKQWFPIMEUNS-UHFFFAOYSA-N 279075 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(5-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 106::US10512632, Example 106::US10766893, Example S106::US10806718, Example 106::US11026923, Example 106::US11491140, Example 106::US11634416, Example 106 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.10 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279075&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273404 378160663 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967453 CCOc1ncccc1-c1cc(NCc2cccc(n2)C(F)(F)F)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H25F3N6O/c1-5-34-23-17(9-7-11-28-23)18-12-19(22-21(31-18)15(4)32-33(22)14(2)3)29-13-16-8-6-10-20(30-16)24(25,26)27/h6-12,14H,5,13H2,1-4H3,(H,29,31) FVVVRFIRYVUVEI-UHFFFAOYSA-N 279076 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[6-(trifluoromethyl)-2-pyridyl]methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 107::US10512632, Example 107::US10766893, Example S107::US10806718, Example 107::US11026923, Example 107::US11491140, Example 107::US11634416, Example 107 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 110 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279076&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273405 378160664 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967456 CCOc1ncccc1-c1cc(NCc2cccn(C)c2=O)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-23-18(10-7-11-25-23)19-13-20(26-14-17-9-8-12-29(5)24(17)31)22-21(27-19)16(4)28-30(22)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,26,27) YLQLMBPUXKUVLD-UHFFFAOYSA-N 279077 3-[[[5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-yl]amino]methyl]-1-methyl-pyridin-2-one::US10034861, Example 108::US10512632, Example 108::US10766893, Example S108::US10806718, Example 108::US11026923, Example 108::US11491140, Example 108::US11634416, Example 108 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.80 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279077&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273406 378160665 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967459 CCOc1ncccc1-c1cc(NCc2cnn(CC)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H29N7O/c1-6-29-14-17(13-26-29)12-25-20-11-19(18-9-8-10-24-23(18)31-7-2)27-21-16(5)28-30(15(3)4)22(20)21/h8-11,13-15H,6-7,12H2,1-5H3,(H,25,27) IEORIQPBXNSJCP-UHFFFAOYSA-N 279078 5-(2-ethoxy-3-pyridyl)-N-[(1-ethylpyrazol-4-yl)methyl]-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 109::US10512632, Example 109::US10766893, Example S109::US10806718, Example 109::US11026923, Example 109::US11491140, Example 109::US11634416, Example 109 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4.90 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279078&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273407 378160666 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967462 CCCn1cc(CNc2cc(nc3c(C)nn(C(C)C)c23)-c2cccnc2OCC)cn1 InChI=1S/C24H31N7O/c1-6-11-30-15-18(14-27-30)13-26-21-12-20(19-9-8-10-25-24(19)32-7-2)28-22-17(5)29-31(16(3)4)23(21)22/h8-10,12,14-16H,6-7,11,13H2,1-5H3,(H,26,28) NPLKFZSTTQLUHS-UHFFFAOYSA-N 279079 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(1-propylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 110::US10512632, Example 110::US10766893, Example S110::US10806718, Example 110::US11026923, Example 110::US11491140, Example 110::US11634416, Example 110 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 11.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279079&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273408 378160667 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967465 CCOc1ncccc1-c1cc(NCc2ccc(OC)nc2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(8-7-11-25-24)19-12-20(26-13-17-9-10-21(31-5)27-14-17)23-22(28-19)16(4)29-30(23)15(2)3/h7-12,14-15H,6,13H2,1-5H3,(H,26,28) XMJAAWKICASNAA-UHFFFAOYSA-N 279080 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(6-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 111::US10512632, Example 111::US10766893, Example S111::US10806718, Example 111::US11026923, Example 111::US11491140, Example 111::US11634416, Example 111 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 28.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279080 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279080&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273409 378160668 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967468 CCOc1ncccc1-c1cc(NCc2ccc(OC)cn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-19(8-7-11-25-24)20-12-21(27-13-17-9-10-18(31-5)14-26-17)23-22(28-20)16(4)29-30(23)15(2)3/h7-12,14-15H,6,13H2,1-5H3,(H,27,28) HWSJSACIWPNYOB-UHFFFAOYSA-N 279081 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(5-methoxy-2-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 112::US10512632, Example 112::US10766893, Example S112::US10806718, Example 112::US11026923, Example 112::US11491140, Example 112::US11634416, Example 112 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 61.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279081&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273411 378160669 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967471 CCOc1ncccc1-c1cc(NCc2csc(C)n2)c2n(nc(C)c2n1)C1COC1 InChI=1S/C22H24N6O2S/c1-4-30-22-17(6-5-7-23-22)18-8-19(24-9-15-12-31-14(3)25-15)21-20(26-18)13(2)27-28(21)16-10-29-11-16/h5-8,12,16H,4,9-11H2,1-3H3,(H,24,26) BSSGJYYHYVLYMA-UHFFFAOYSA-N 279082 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(2-methylthiazol-4-yl)methyl]-1-(oxetan-3-yl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 113::US10512632, Example 113::US10618913, Example S113::US10766893, Example S113::US10806718, Example 113::US11026923, Example 113::US11491140, Example 113::US11634416, Example 113 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 110 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279082&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273410 378160670 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967474 CCOc1ncccc1-c1cc(NCc2cnc(OC)cn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O2/c1-6-32-23-17(8-7-9-24-23)18-10-19(26-11-16-12-27-20(31-5)13-25-16)22-21(28-18)15(4)29-30(22)14(2)3/h7-10,12-14H,6,11H2,1-5H3,(H,26,28) QIWVSVNHRDQBOW-UHFFFAOYSA-N 279083 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(5-methoxypyrazin-2-yl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 114::US10512632, Example 114::US10766893, Example S114::US10806718, Example 114::US11026923, Example 114::US11491140, Example 114::US11634416, Example 114 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 24.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279083 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279083&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273413 378160671 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967477 CCOc1ncccc1-c1cc(NCc2cccnc2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H26N6O/c1-5-30-23-18(9-7-11-25-23)19-12-20(26-14-17-8-6-10-24-13-17)22-21(27-19)16(4)28-29(22)15(2)3/h6-13,15H,5,14H2,1-4H3,(H,26,27) MYYHBCJMEYIHMC-UHFFFAOYSA-N 279084 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(3-pyridylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 115::US10512632, Example 115::US10766893, Example S115::US10806718, Example 115::US11026923, Example 115::US11491140, Example 115::US11634416, Example 115 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 15.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279084&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273412 378160672 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967480 CCOc1ncccc1-c1cc(NCc2ccc(F)nc2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H25FN6O/c1-5-31-23-17(7-6-10-25-23)18-11-19(26-12-16-8-9-20(24)27-13-16)22-21(28-18)15(4)29-30(22)14(2)3/h6-11,13-14H,5,12H2,1-4H3,(H,26,28) SKXWAYULKGVUDE-UHFFFAOYSA-N 279085 5-(2-ethoxy-3-pyridyl)-N-[(6-fluoro-3-pyridyl)methyl]-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 116::US10512632, Example 116::US10766893, Example S116::US10806718, Example 116::US11026923, Example 116::US11491140, Example 116::US11634416, Example 116 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 21.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279085&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273414 378160673 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967483 CCOc1ncccc1-c1cc(NCc2ccc(nc2)C(F)F)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H26F2N6O/c1-5-33-24-17(7-6-10-27-24)19-11-20(22-21(30-19)15(4)31-32(22)14(2)3)29-13-16-8-9-18(23(25)26)28-12-16/h6-12,14,23H,5,13H2,1-4H3,(H,29,30) FDEJYPFAUDLEJD-UHFFFAOYSA-N 279086 N-[[6-(difluoromethyl)-3-pyridyl]methyl]-5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 117::US10512632, Example 117::US10766893, Example S117::US10806718, Example 117::US11026923, Example 117::US11491140, Example 117::US11634416, Example 117 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 18.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279086&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273416 378160674 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967486 CCOc1ncccc1-c1cc(NCc2ncccc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-17(9-7-12-26-24)18-13-19(27-14-20-21(31-5)10-8-11-25-20)23-22(28-18)16(4)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) CQZGCHPJVLXYPV-UHFFFAOYSA-N 279087 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(3-methoxy-2-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 118::US10512632, Example 118::US10766893, Example S118::US10806718, Example 118::US11026923, Example 118::US11491140, Example 118::US11634416, Example 118 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 13.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279087&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273417 378160675 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967489 CCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(nc(C)c2n1)C(C)CC 279088 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 119::US10034861, Example 120::US10512632, Example 120::US10618913, Example S120::US10766893, Example S120::US10806718, Example 120::US11026923, Example 120::US11634416, Example 120 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 12.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279088&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273415 378160676 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967492 CCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(nc(C)c2n1)C(C)CC 279088 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 119::US10034861, Example 120::US10512632, Example 120::US10618913, Example S120::US10766893, Example S120::US10806718, Example 120::US11026923, Example 120::US11634416, Example 120 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4.60 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279088&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273415 378160676 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967495 CCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C22H28N8O/c1-6-14(3)30-21-18(24-12-19-25-13-29(5)28-19)11-17(26-20(21)15(4)27-30)16-9-8-10-23-22(16)31-7-2/h8-11,13-14H,6-7,12H2,1-5H3,(H,24,26) RANZHWURGHEKDD-UHFFFAOYSA-N 279090 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 121::US10034861, Example 122::US10512632, Example 122::US10766893, Example S122::US10806718, Example 122::US11634416, Example 122 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4.00 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279090&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273418 378160677 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967498 CCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C22H28N8O/c1-6-14(3)30-21-18(24-12-19-25-13-29(5)28-19)11-17(26-20(21)15(4)27-30)16-9-8-10-23-22(16)31-7-2/h8-11,13-14H,6-7,12H2,1-5H3,(H,24,26) RANZHWURGHEKDD-UHFFFAOYSA-N 279090 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 121::US10034861, Example 122::US10512632, Example 122::US10766893, Example S122::US10806718, Example 122::US11634416, Example 122 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.20 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279090&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273418 378160677 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967501 CCOc1ncccc1-c1cc(NCc2nnc(C)o2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C22H27N7O2/c1-6-13(3)29-21-18(24-12-19-27-26-15(5)31-19)11-17(25-20(21)14(4)28-29)16-9-8-10-23-22(16)30-7-2/h8-11,13H,6-7,12H2,1-5H3,(H,24,25) SJDHGTJKQKPRAR-UHFFFAOYSA-N 279092 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(5-methyl-1,3,4-oxadiazol-2-yl)methyl]-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 123::US10034861, Example 124::US10512632, Example 123::US10766893, Example S124::US10806718, Example 124::US11634416, Example 124 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 54.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279092&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273419 378160678 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967504 CCOc1ncccc1-c1cc(NCc2nnc(C)o2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C22H27N7O2/c1-6-13(3)29-21-18(24-12-19-27-26-15(5)31-19)11-17(25-20(21)14(4)28-29)16-9-8-10-23-22(16)30-7-2/h8-11,13H,6-7,12H2,1-5H3,(H,24,25) SJDHGTJKQKPRAR-UHFFFAOYSA-N 279092 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(5-methyl-1,3,4-oxadiazol-2-yl)methyl]-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 123::US10034861, Example 124::US10512632, Example 123::US10766893, Example S124::US10806718, Example 124::US11634416, Example 124 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 9.70 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279092&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273419 378160678 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967507 CCOc1ncccc1-c1cc(NCc2cncc(OC)c2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C25H30N6O2/c1-6-16(3)31-24-22(28-14-18-11-19(32-5)15-26-13-18)12-21(29-23(24)17(4)30-31)20-9-8-10-27-25(20)33-7-2/h8-13,15-16H,6-7,14H2,1-5H3,(H,28,29) SYWOKLNWWYOPHL-UHFFFAOYSA-N 279094 5-(2-ethoxy-3-pyridyl)-N-[(5-methoxy-3-pyridyl)methyl]-3-methyl-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 125::US10512632, Example 125::US10766893, Example S125::US10806718, Example 125::US11634416, Example 125 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.000 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279094&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273422 378160679 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967510 CCOc1ncccc1-c1cc(NCc2ccnc(OC)c2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C25H30N6O2/c1-6-16(3)31-24-21(28-15-18-10-12-26-22(13-18)32-5)14-20(29-23(24)17(4)30-31)19-9-8-11-27-25(19)33-7-2/h8-14,16H,6-7,15H2,1-5H3,(H,28,29) JRNBIFGQRNWOKC-UHFFFAOYSA-N 279095 5-(2-ethoxy-3-pyridyl)-N-[(2-methoxy-4-pyridyl)methyl]-3-methyl-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 126::US10512632, Example 126::US10766893, Example S126::US10806718, Example 126::US11634416, Example 126 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 5.40 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279095&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273420 378160680 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967513 CCOc1ncccc1-c1cc(NCc2nnn(C)n2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C21H27N9O/c1-6-13(3)30-20-17(23-12-18-25-28-29(5)27-18)11-16(24-19(20)14(4)26-30)15-9-8-10-22-21(15)31-7-2/h8-11,13H,6-7,12H2,1-5H3,(H,23,24) ULBLNKNNIPTFLN-UHFFFAOYSA-N 279096 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]-N-[(2-methyltetrazol-5-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 127::US10512632, Example 127::US10766893, Example S127::US10806718, Example 127::US11634416, Example 127 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.80 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279096&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273421 378160681 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967516 CCOc1ncccc1-c1cc(NCc2noc(C)n2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C22H27N7O2/c1-6-13(3)29-21-18(24-12-19-25-15(5)31-28-19)11-17(26-20(21)14(4)27-29)16-9-8-10-23-22(16)30-7-2/h8-11,13H,6-7,12H2,1-5H3,(H,24,26) XOIXJVILDWTHEL-UHFFFAOYSA-N 279097 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 128::US10512632, Example 128::US10766893, Example S128::US10806718, Example 128::US11634416, Example 128 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.20 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279097 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279097&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273425 378160682 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967519 CCOc1ncccc1-c1cc(NCc2coc(C)n2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C23H28N6O2/c1-6-14(3)29-22-20(25-12-17-13-31-16(5)26-17)11-19(27-21(22)15(4)28-29)18-9-8-10-24-23(18)30-7-2/h8-11,13-14H,6-7,12H2,1-5H3,(H,25,27) NAPUFLNYEBBQPU-UHFFFAOYSA-N 279098 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(2-methyloxazol-4-yl)methyl]-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 129::US10512632, Example 129::US10766893, Example S129::US10806718, Example 129::US11634416, Example 129 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 11.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279098 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279098&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273423 378160683 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967522 CCOc1ncccc1-c1cc(NCc2c[nH]cn2)c2n(nc(C)c2n1)C(C)CC 279099 5-(2-ethoxy-3-pyridyl)-N-(1H-imidazol-4-ylmethyl)-3-methyl-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 130::US10512632, Example 130::US10766893, Example S130::US10806718, Example 130::US11634416, Example 130 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 11.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279099&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273424 378160684 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967525 CCOc1ncccc1-c1cc(NCc2cc(C)[nH]n2)c2n(nc(C)c2n1)C(C)CC 279100 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]-N-[(5-methyl-1H-pyrazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 131::US10512632, Example 131::US10766893, Example S131::US10806718, Example 131::US11634416, Example 131 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.350 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279100 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279100&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273426 378160685 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967528 CCOc1ncccc1-c1cc(NCc2cn(C)cn2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C23H29N7O/c1-6-15(3)30-22-20(25-12-17-13-29(5)14-26-17)11-19(27-21(22)16(4)28-30)18-9-8-10-24-23(18)31-7-2/h8-11,13-15H,6-7,12H2,1-5H3,(H,25,27) NIXYLBKMUOTNON-UHFFFAOYSA-N 279101 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(1-methylimidazol-4-yl)methyl]-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 132::US10512632, Example 132::US10766893, Example S132::US10806718, Example 132::US11634416, Example 132 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.140 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279101&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273427 378160686 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967531 CCOc1ncccc1-c1cc(NCc2cnc(C)o2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C23H28N6O2/c1-6-14(3)29-22-20(26-13-17-12-25-16(5)31-17)11-19(27-21(22)15(4)28-29)18-9-8-10-24-23(18)30-7-2/h8-12,14H,6-7,13H2,1-5H3,(H,26,27) ZJGPWXQIKUCOGR-UHFFFAOYSA-N 279102 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(2-methyloxazol-5-yl)methyl]-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 133::US10512632, Example 133::US10766893, Example S133::US10806718, Example 133::US11634416, Example 133 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 11.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279102&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273428 378160687 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967534 CCCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C23H30N8O/c1-6-11-32-23-17(9-8-10-24-23)18-12-19(25-13-20-26-14-30(5)29-20)22-21(27-18)16(4)28-31(22)15(3)7-2/h8-10,12,14-15H,6-7,11,13H2,1-5H3,(H,25,27) SXNFSKBWTTYFLI-UHFFFAOYSA-N 279103 3-methyl-1-[1-methylpropyl]-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]-5-(2-propoxy-3-pyridyl)pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 134::US10512632, Example 134::US10766893, Example S134::US10806718, Example 134::US11491140, Example 134::US11634416, Example 134 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.960 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279103&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273429 378160688 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967537 CCCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(nc(C)c2n1)C(C)CC 279104 3-methyl-1-[1-methylpropyl]-5-(2-propoxy-3-pyridyl)-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 135::US10512632, Example 135::US10766893, Example S135::US10806718, Example 135::US11491140, Example 135::US11634416, Example 135 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.90 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279104&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273430 378160689 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967540 CCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(ncc2n1)C(C)CC 279105 5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine, enantiomer 1::US10034861, Example 136::US10034861, Example 137::US10512632, Example 137::US10766893, Example S137::US10806718, Example 137::US11026923, Example 137::US11491140, Example 137::US11634416, Example 137 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 62.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279105&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273431 378160690 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967543 CCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(ncc2n1)C(C)CC 279105 5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine, enantiomer 1::US10034861, Example 136::US10034861, Example 137::US10512632, Example 137::US10766893, Example S137::US10806718, Example 137::US11026923, Example 137::US11491140, Example 137::US11634416, Example 137 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 180 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279105&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273431 378160690 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967546 CCOc1ncccc1-c1cc(NCc2nnc(C)o2)c2n(ncc2n1)C(C)CC InChI=1S/C21H25N7O2/c1-5-13(3)28-20-17(23-12-19-27-26-14(4)30-19)10-16(25-18(20)11-24-28)15-8-7-9-22-21(15)29-6-2/h7-11,13H,5-6,12H2,1-4H3,(H,23,25) BIQGCKNODPBTSC-UHFFFAOYSA-N 279107 5-(2-ethoxy-3-pyridyl)-N-[(5-methyl-1,3,4-oxadiazol-2-yl)methyl]-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 138::US10034861, Example 139::US10512632, Example 139::US10766893, Example S139::US10806718, Example 139::US11026923, Example 139::US11491140, Example 139::US11634416, Example 139 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 93.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279107&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273432 378160691 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967549 CCOc1ncccc1-c1cc(NCc2nnc(C)o2)c2n(ncc2n1)C(C)CC InChI=1S/C21H25N7O2/c1-5-13(3)28-20-17(23-12-19-27-26-14(4)30-19)10-16(25-18(20)11-24-28)15-8-7-9-22-21(15)29-6-2/h7-11,13H,5-6,12H2,1-4H3,(H,23,25) BIQGCKNODPBTSC-UHFFFAOYSA-N 279107 5-(2-ethoxy-3-pyridyl)-N-[(5-methyl-1,3,4-oxadiazol-2-yl)methyl]-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 138::US10034861, Example 139::US10512632, Example 139::US10766893, Example S139::US10806718, Example 139::US11026923, Example 139::US11491140, Example 139::US11634416, Example 139 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 330 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279107&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273432 378160691 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967552 CCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(ncc2n1)C(C)CC InChI=1S/C21H26N8O/c1-5-14(3)29-20-17(23-12-19-24-13-28(4)27-19)10-16(26-18(20)11-25-29)15-8-7-9-22-21(15)30-6-2/h7-11,13-14H,5-6,12H2,1-4H3,(H,23,26) OKQUCPHNAVGTKM-UHFFFAOYSA-N 279109 5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 140::US10034861, Example 141::US10512632, Example 141::US10766893, Example S141::US10806718, Example 141::US11026923, Example 141::US11491140, Example 141::US11634416, Example 141 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 32.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279109&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273433 378160692 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967555 CCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(ncc2n1)C(C)CC InChI=1S/C21H26N8O/c1-5-14(3)29-20-17(23-12-19-24-13-28(4)27-19)10-16(26-18(20)11-25-29)15-8-7-9-22-21(15)30-6-2/h7-11,13-14H,5-6,12H2,1-4H3,(H,23,26) OKQUCPHNAVGTKM-UHFFFAOYSA-N 279109 5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 140::US10034861, Example 141::US10512632, Example 141::US10766893, Example S141::US10806718, Example 141::US11026923, Example 141::US11491140, Example 141::US11634416, Example 141 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 44.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279109&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273433 378160692 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967558 CCCOc1ncccc1-c1cc(NCc2cn(C)cn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H29N7O/c1-6-10-31-23-18(8-7-9-24-23)19-11-20(25-12-17-13-29(5)14-26-17)22-21(27-19)16(4)28-30(22)15(2)3/h7-9,11,13-15H,6,10,12H2,1-5H3,(H,25,27) KLLVPOPJMWWQFO-UHFFFAOYSA-N 279111 1-isopropyl-3-methyl-N-[(1-methylimidazol-4-yl)methyl]-5-(2-propoxy-3-pyridyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 142::US10512632, Example 142::US10766893, Example S142::US10806718, Example 142::US11491140, Example 142::US11634416, Example 142 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.260 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279111&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273434 378160693 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967561 CCCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H27N7O/c1-5-11-30-22-17(7-6-9-23-22)18-12-19(24-13-16-8-10-25-27-16)21-20(26-18)15(4)28-29(21)14(2)3/h6-10,12,14H,5,11,13H2,1-4H3,(H,24,26)(H,25,27) WVFCCHYAETYKIF-UHFFFAOYSA-N 279112 1-isopropyl-3-methyl-5-(2-propoxy-3-pyridyl)-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 143::US10512632, Example 143::US10766893, Example S143::US10806718, Example 143::US11026923, Example 143::US11491140, Example 143::US11634416, Example 143 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 3.80 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279112&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273435 378160694 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967564 CCOc1ncccc1-c1cc(NCc2nc[nH]n2)c2n(nc(C)c2n1)C(C)CC 279113 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]-N-(1H-1,2,4-triazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 144::US10512632, Example 144::US10766893, Example S144::US10806718, Example 144::US11026923, Example 144::US11491140, Example 144::US11634416, Example 144 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 14.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279113&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273438 378160695 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967567 CCCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H28N8O/c1-6-10-31-22-16(8-7-9-23-22)17-11-18(24-12-19-25-13-29(5)28-19)21-20(26-17)15(4)27-30(21)14(2)3/h7-9,11,13-14H,6,10,12H2,1-5H3,(H,24,26) ROWMNTAKQCZGNZ-UHFFFAOYSA-N 279114 1-isopropyl-3-methyl-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]-5-(2-propoxy-3-pyridyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 145::US10512632, Example 145::US10766893, Example S145::US10806718, Example 145::US11026923, Example 145::US11491140, Example 145::US11634416, Example 145 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.410 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279114&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273436 378160696 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967570 CCCOc1ncccc1-c1cc(NCc2nc[nH]n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-5-9-30-21-15(7-6-8-22-21)16-10-17(23-11-18-24-12-25-27-18)20-19(26-16)14(4)28-29(20)13(2)3/h6-8,10,12-13H,5,9,11H2,1-4H3,(H,23,26)(H,24,25,27) RLGQIPCFRYRCDL-UHFFFAOYSA-N 279115 1-isopropyl-3-methyl-5-(2-propoxy-3-pyridyl)-N-(1H-1,2,4-triazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 146::US10512632, Example 146::US10766893, Example S146::US10806718, Example 146::US11026923, Example 146::US11491140, Example 146::US11634416, Example 146 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 3.90 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279115&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273440 378160697 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967573 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1nccs1 InChI=1S/C18H21N7S/c1-11(2)25-17-14(20-8-13-9-21-24(4)10-13)7-15(18-19-5-6-26-18)22-16(17)12(3)23-25/h5-7,9-11H,8H2,1-4H3,(H,20,22) TVGMRVMYCDHOEG-UHFFFAOYSA-N 279116 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-thiazol-2-yl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 147::US10512632, Example 147::US10618913, Example S147::US10766893, Example S147::US10806718, Example 147::US11026923, Example 147::US11491140, Example 147::US11634416, Example 147 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 12.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279116&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273437 378160698 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967576 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1ncc(C)s1 InChI=1S/C19H23N7S/c1-11(2)26-18-15(20-8-14-9-22-25(5)10-14)6-16(19-21-7-12(3)27-19)23-17(18)13(4)24-26/h6-7,9-11H,8H2,1-5H3,(H,20,23) ACZBEPYVSHJPFB-UHFFFAOYSA-N 279117 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-(5-methylthiazol-2-yl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 148::US10512632, Example 148::US10766893, Example S148::US10806718, Example 148::US11026923, Example 148::US11491140, Example 148::US11634416, Example 148 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 110 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279117&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273439 378160699 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967579 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1nc(C)cs1 InChI=1S/C19H23N7S/c1-11(2)26-18-15(20-7-14-8-21-25(5)9-14)6-16(19-22-12(3)10-27-19)23-17(18)13(4)24-26/h6,8-11H,7H2,1-5H3,(H,20,23) HCLONMUJAHJFIH-UHFFFAOYSA-N 279118 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-(4-methylthiazol-2-yl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 149::US10512632, Example 149::US10766893, Example S149::US10806718, Example 149::US11026923, Example 149::US11491140, Example 149::US11634416, Example 149 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 29.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279118&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273441 378160700 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967582 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)N1CC(C)OC1=O InChI=1S/C19H25N7O2/c1-11(2)26-18-15(20-7-14-8-21-24(5)10-14)6-16(22-17(18)13(4)23-26)25-9-12(3)28-19(25)27/h6,8,10-12H,7,9H2,1-5H3,(H,20,22) YBJPEIIVVVNBPC-UHFFFAOYSA-N 279119 3-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]-5-methyl-oxazolidin-2-one::US10034861, Example 150::US10512632, Example 150::US10766893, Example S150::US10806718, Example 150::US11026923, Example 150::US11491140, Example 150::US11634416, Example 150 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 44.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279119&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273442 378160701 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967585 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)N1CCOC1=O InChI=1S/C18H23N7O2/c1-11(2)25-17-14(19-8-13-9-20-23(4)10-13)7-15(21-16(17)12(3)22-25)24-5-6-27-18(24)26/h7,9-11H,5-6,8H2,1-4H3,(H,19,21) CBOOBJUJEUVRPS-UHFFFAOYSA-N 279120 3-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]oxazolidin-2-one::US10034861, Example 151::US10512632, Example 151::US10766893, Example S151::US10806718, Example 151::US11026923, Example 151::US11491140, Example 151::US11634416, Example 151 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 10.00 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279120&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273443 378160702 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967588 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)N1CCC1=O InChI=1S/C18H23N7O/c1-11(2)25-18-14(19-8-13-9-20-23(4)10-13)7-15(24-6-5-16(24)26)21-17(18)12(3)22-25/h7,9-11H,5-6,8H2,1-4H3,(H,19,21) SLJWZSCTWDVJBR-UHFFFAOYSA-N 279121 1-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]azetidin-2-one::US10034861, Example 152::US10512632, Example 152::US10766893, Example S152::US10806718, Example 152::US11026923, Example 152::US11491140, Example 152::US11634416, Example 152 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 48.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279121&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273444 378160703 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967591 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)N1CCN(C1=O)C(C)(C)C InChI=1S/C22H32N8O/c1-14(2)30-20-17(23-11-16-12-24-27(7)13-16)10-18(25-19(20)15(3)26-30)28-8-9-29(21(28)31)22(4,5)6/h10,12-14H,8-9,11H2,1-7H3,(H,23,25) KIFHGJKUXDTDBI-UHFFFAOYSA-N 279122 1-tert-butyl-3-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]imidazolidin-2-one::US10034861, Example 153::US10512632, Example 153::US10766893, Example S153::US10806718, Example 153::US11026923, Example 153::US11491140, Example 153::US11634416, Example 153 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 130 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279122&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273445 378160704 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967594 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)N1CCCC1=O InChI=1S/C19H25N7O/c1-12(2)26-19-15(20-9-14-10-21-24(4)11-14)8-16(22-18(19)13(3)23-26)25-7-5-6-17(25)27/h8,10-12H,5-7,9H2,1-4H3,(H,20,22) CXGJWWJDXYZFFZ-UHFFFAOYSA-N 279123 1-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]pyrrolidin-2-one::US10034861, Example 154::US10512632, Example 154::US10766893, Example S154::US10806718, Example 154::US11026923, Example 154::US11491140, Example 154::US11634416, Example 154 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 26.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279123&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273446 378160705 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967597 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)N1C(C)COC1=O InChI=1S/C19H25N7O2/c1-11(2)26-18-15(20-7-14-8-21-24(5)9-14)6-16(22-17(18)13(4)23-26)25-12(3)10-28-19(25)27/h6,8-9,11-12H,7,10H2,1-5H3,(H,20,22) DXKZTPARVQEQMA-UHFFFAOYSA-N 279124 3-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]-4-methyl-oxazolidin-2-one::US10034861, Example 155::US10512632, Example 155::US10766893, Example S155::US10806718, Example 155::US11026923, Example 155::US11491140, Example 155::US11634416, Example 155 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.20 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279124&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273447 378160706 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967600 CCC1COC(=O)N1c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C20H27N7O2/c1-6-15-11-29-20(28)26(15)17-7-16(21-8-14-9-22-25(5)10-14)19-18(23-17)13(4)24-27(19)12(2)3/h7,9-10,12,15H,6,8,11H2,1-5H3,(H,21,23) CVOILQIVJFYVAQ-UHFFFAOYSA-N 279125 4-ethyl-3-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]oxazolidin-2-one::US10034861, Example 156::US10512632, Example 156::US10766893, Example S156::US10806718, Example 156::US11026923, Example 156::US11491140, Example 156::US11634416, Example 156 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 31.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279125&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273448 378160707 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967603 CCOc1ncccc1-c1cc(CNc2cncc(OC)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-20(8-7-9-26-24)21-10-17(12-27-18-11-19(31-5)14-25-13-18)23-22(28-21)16(4)29-30(23)15(2)3/h7-11,13-15,27H,6,12H2,1-5H3 BXZMPJVMGAVKJS-UHFFFAOYSA-N 279126 N-[[5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-yl]methyl]-5-methoxy-pyridin-3-amine::US10034861, Example 157::US10512632, Example 157::US10766893, Example S157::US10806718, Example 157::US11026923, Example 157::US11491140, Example 157::US11634416, Example 157 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 34.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279126&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273449 378160708 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967606 CCOc1ncccc1-c1cc(CNc2ncn(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-6-30-20-16(8-7-9-22-20)17-10-15(11-23-21-24-12-28(5)27-21)19-18(25-17)14(4)26-29(19)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,23,27) XUAILHHYTLESDG-UHFFFAOYSA-N 279127 N-[[5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-yl]methyl]-1-methyl-1,2,4-triazol-3-amine::US10034861, Example 158::US10512632, Example 158::US10766893, Example S158::US10806718, Example 158::US11026923, Example 158::US11491140, Example 158::US11634416, Example 158 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 23.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279127&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273450 378160709 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967609 CCOc1ncccc1-c1cc(CCc2cncc(OC)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C25H29N5O2/c1-6-32-25-21(8-7-11-27-25)22-13-19(10-9-18-12-20(31-5)15-26-14-18)24-23(28-22)17(4)29-30(24)16(2)3/h7-8,11-16H,6,9-10H2,1-5H3 KRADQTILGMSJGT-UHFFFAOYSA-N 279128 5-(2-ethoxy-3-pyridyl)-1-isopropyl-7-[2-(5-methoxy-3-pyridyl)ethyl]-3-methyl-pyrazolo[4,3-b]pyridine::US10034861, Example 159::US10512632, Example 159::US10766893, Example S159::US10806718, Example 159::US11026923, Example 159::US11491140, Example 159::US11634416, Example 159 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 270 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279128&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273451 378160710 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967612 CCOc1ncccc1-c1cc(CCc2ncn(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H27N7O/c1-6-30-22-17(8-7-11-23-22)18-12-16(9-10-19-24-13-28(5)27-19)21-20(25-18)15(4)26-29(21)14(2)3/h7-8,11-14H,6,9-10H2,1-5H3 DQKKFAGODSQYOO-UHFFFAOYSA-N 279129 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-7-[2-(1-methyl-1,2,4-triazol-3-yl)ethyl]pyrazolo[4,3-b]pyridine::US10034861, Example 160::US10512632, Example 160::US10766893, Example S160::US10806718, Example 160::US11026923, Example 160::US11491140, Example 160::US11634416, Example 160 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 23.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279129&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273452 378160711 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967615 CCOc1ncccc1-c1cc(NCc2ncnn2C)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-6-30-21-15(8-7-9-22-21)16-10-17(23-11-18-24-12-25-28(18)5)20-19(26-16)14(4)27-29(20)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,23,26) DSJWNAKWTOCISO-UHFFFAOYSA-N 425070 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methyl-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10512632, Example 161::US10618913, Example S161::US10766893, Example S161::US10806718, Example 161::US11026923, Example 161::US11491140, Example 162::US11634416, Example 161 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 60.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=425070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=425070&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138536279 434150493 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967618 CCOc1ncccc1-c1cc(NCC2=NNCN2C)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H28N8O/c1-6-30-21-15(8-7-9-22-21)16-10-17(23-11-18-26-24-12-28(18)5)20-19(25-16)14(4)27-29(20)13(2)3/h7-10,13,24H,6,11-12H2,1-5H3,(H,23,25) VERYSPNRLYNKET-UHFFFAOYSA-N 468474 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N- [(4-methyl-1,2,4-triazol-3- yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10806718, Example 162 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 100.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=468474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=468474&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 155921700 441570575 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967621 CCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(nc(C)c2n1)C1COC1 InChI=1S/C21H24N8O2/c1-4-31-21-15(6-5-7-22-21)16-8-17(23-9-18-24-12-28(3)27-18)20-19(25-16)13(2)26-29(20)14-10-30-11-14/h5-8,12,14H,4,9-11H2,1-3H3,(H,23,25) KHCSAUOHEOUDEI-UHFFFAOYSA-N 279132 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]-1-(oxetan-3-yl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 163::US10512632, Example 163::US10618913, Example S163::US10766893, Example S163::US10806718, Example 163::US11026923, Example 163::US11491140, Example 163::US11634416, Example 163 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 120 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279132&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273457 378160713 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967624 CCOc1ncccc1-c1cc(SCCC(=O)OCC(C)C)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H32N4O3S/c1-7-30-24-18(9-8-11-25-24)19-13-20(32-12-10-21(29)31-14-15(2)3)23-22(26-19)17(6)27-28(23)16(4)5/h8-9,11,13,15-16H,7,10,12,14H2,1-6H3 HVDCJFCTBUPVCE-UHFFFAOYSA-N 279133 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylsulfanyl]pyrazolo[4,3-b]pyridine::US10034861, Example 164::US10806718, Example 164::US11026923, Example 164::US11491140, Example 164::US11634416, Example 164 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 6.80 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279133&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273278 378160714 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967627 CCOc1ncccc1-c1cc(N(Cc2nnn(n2)C(F)F)Cc2ccc(OC)cc2)c2n(nc(C)c2n1)C(C)C InChI=1S/C28H31F2N9O2/c1-6-41-27-21(8-7-13-31-27)22-14-23(26-25(32-22)18(4)34-38(26)17(2)3)37(15-19-9-11-20(40-5)12-10-19)16-24-33-36-39(35-24)28(29)30/h7-14,17,28H,6,15-16H2,1-5H3 LFWTZADBQWTBSM-UHFFFAOYSA-N 468477 N-[[1-(difluoromethyl)pyrazol-4-yl]methyl]-5- (2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl- pyrazolo[4,3-b]pyridin-7-amine::US10806718, Example 165 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 73.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=468477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=468477&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 146593933 441570578 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967630 CCOc1ncccc1-c1cc(NCc2cc(CF)on2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H25FN6O2/c1-5-30-22-17(7-6-8-24-22)18-10-19(25-12-15-9-16(11-23)31-28-15)21-20(26-18)14(4)27-29(21)13(2)3/h6-10,13H,5,11-12H2,1-4H3,(H,25,26) XUHFADCPGYKQAR-UHFFFAOYSA-N 279135 5-(2-ethoxy-3-pyridyl)-N-[[5-(fluoromethyl)isoxazol-3-yl]methyl]-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::BDBM425076::US10034861, Example 166::US10512632, Example 166::US10766893, Example S166::US10806718, Example 166::US11026923, Example 166::US11491140, Example 166::US11634416, Example 166 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.10 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279135&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273459 378160716 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967633 CCOc1ncccc1-c1cc(NCc2cc(CF)no2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H25FN6O2/c1-5-30-22-17(7-6-8-24-22)18-10-19(25-12-16-9-15(11-23)28-31-16)21-20(26-18)14(4)27-29(21)13(2)3/h6-10,13H,5,11-12H2,1-4H3,(H,25,26) VTULNMARMGUDCN-UHFFFAOYSA-N 279136 5-(2-ethoxy-3-pyridyl)-N-[[3-(fluoromethyl)isoxazol-5-yl]methyl]-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 167::US10766893, Example S167::US10806718, Example 167::US11026923, Example 167::US11491140, Example 167::US11634416, Example 167 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 11.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279136&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273460 378160717 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967636 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1ncco1 InChI=1S/C18H21N7O/c1-11(2)25-17-14(20-8-13-9-21-24(4)10-13)7-15(18-19-5-6-26-18)22-16(17)12(3)23-25/h5-7,9-11H,8H2,1-4H3,(H,20,22) IMKYKBMLZRNQRQ-UHFFFAOYSA-N 279137 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-oxazol-2-yl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 168::US10512632, Example 168::US10618913, Example S168::US10766893, Example S168::US10806718, Example 168::US11026923, Example 168::US11491140, Example 168::US11634416, Example 168 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 14.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279137&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273461 378160718 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967639 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1cnnn1C InChI=1S/C18H23N9/c1-11(2)27-18-15(19-7-13-8-21-25(4)10-13)6-14(16-9-20-24-26(16)5)22-17(18)12(3)23-27/h6,8-11H,7H2,1-5H3,(H,19,22) YPYKZBZKFWCVCN-UHFFFAOYSA-N 279138 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-(3-methyltriazol-4-yl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 169::US10512632, Example 169::US10618913, Example S169::US10766893, Example S169::US10806718, Example 169::US11026923, Example 169::US11491140, Example 169::US11634416, Example 169 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 610 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279138&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273462 378160719 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967642 COc1ncccc1-c1cc(NCc2cccnc2C(F)(F)F)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H23F3N6O/c1-13(2)32-20-18(29-12-15-7-5-9-27-21(15)23(24,25)26)11-17(30-19(20)14(3)31-32)16-8-6-10-28-22(16)33-4/h5-11,13H,12H2,1-4H3,(H,29,30) GLFDPBHOMZCMEF-UHFFFAOYSA-N 279139 1-isopropyl-5-(2-methoxy-3-pyridyl)-3-methyl-N-[[2-(trifluoromethyl)-3-pyridyl]methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 170::US10512632, Example 170::US10766893, Example S170::US10806718, Example 170::US11026923, Example 170::US11491140, Example 170::US11634416, Example 170 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 42.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279139&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273463 378160720 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967645 COc1ncccc1CNc1cc(nc2c(C)nn(C(C)C)c12)-c1ccc[nH]c1=O InChI=1S/C22H24N6O2/c1-13(2)28-20-18(25-12-15-7-5-10-24-22(15)30-4)11-17(26-19(20)14(3)27-28)16-8-6-9-23-21(16)29/h5-11,13H,12H2,1-4H3,(H,23,29)(H,25,26) YJCZMNIYQABZMT-UHFFFAOYSA-N 279140 3-[1-isopropyl-7-[(2-methoxy-3-pyridyl)methylamino]-3-methyl-pyrazolo[4,3-b]pyridin-5-yl]-1H-pyridin-2-one::US10034861, Example 171::US10512632, Example 171::US10766893, Example S171::US10806718, Example 171::US11026923, Example 171::US11491140, Example 171::US11634416, Example 171 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 290 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279140 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279140&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 136214892 378160721 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967648 CCOc1ncccc1-c1cc(NCc2ccncc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(8-7-10-26-24)19-12-20(27-13-17-9-11-25-14-21(17)31-5)23-22(28-19)16(4)29-30(23)15(2)3/h7-12,14-15H,6,13H2,1-5H3,(H,27,28) ZDNREOIUOKDWKN-UHFFFAOYSA-N 425081 US10512632, Example 172::US10766893, Example S172::US10806718, Example 172::US11026923, Example 172::US11491140, Example 172::US11634416, Example 172 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 40.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=425081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=425081&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138535948 434150496 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967651 CCOc1ccnc(OC)c1-c1cc(NCc2cnc(C)s2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H28N6O2S/c1-7-31-19-8-9-24-23(30-6)20(19)17-10-18(26-12-16-11-25-15(5)32-16)22-21(27-17)14(4)28-29(22)13(2)3/h8-11,13H,7,12H2,1-6H3,(H,26,27) RUGHPDXPYUYBHP-UHFFFAOYSA-N 468485 1-isopropyl-5-(2-methoxy-3-pyridyl)-3-methyl- N-[(2-methylthiazol-5-yl)methyl]pyrazolo[4,3- b]pyridin-7-amine::US10806718, Example 173 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 49.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=468485 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=468485&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 146593932 441570586 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967654 COc1ncccc1CNc1cc(nc2c(C)nn(C(C)C)c12)-c1cccnc1OC1CC1 InChI=1S/C25H28N6O2/c1-15(2)31-23-21(28-14-17-7-5-11-26-24(17)32-4)13-20(29-22(23)16(3)30-31)19-8-6-12-27-25(19)33-18-9-10-18/h5-8,11-13,15,18H,9-10,14H2,1-4H3,(H,28,29) QLFKDVQWAWXRKU-UHFFFAOYSA-N 279143 5-(2-cyclopropoxypyridin-3-yl)-1-isopropyl-N-((2-methoxypyridin-3-yl)methyl)-3-methyl-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 174::US10512632, Example 174::US10766893, Example S174::US10806718, Example 174::US11026923, Example 174::US11491140, Example 174::US11634416, Example 174 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 18.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279143 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279143&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273466 378160723 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967657 COc1ncccc1CNc1cc(nc2c(C)nn(C(C)C)c12)-c1ccnn1C InChI=1S/C21H25N7O/c1-13(2)28-20-17(23-12-15-7-6-9-22-21(15)29-5)11-16(18-8-10-24-27(18)4)25-19(20)14(3)26-28/h6-11,13H,12H2,1-5H3,(H,23,25) CROUXODBTXNMIZ-UHFFFAOYSA-N 279144 1-isopropyl-N-((2-methoxypyridin-3-yl)methyl)-3-methyl-5-(1-methyl-1H-pyrazol-5-yl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 175::US10512632, Example 175::US10766893, Example S175::US10806718, Example 175::US11026923, Example 175::US11491140, Example 175::US11634416, Example 175 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 83.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279144&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273467 378160724 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967660 CCOc1ncccc1-c1cc(NCc2ncc(OC)cn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O2/c1-6-32-23-17(8-7-9-24-23)18-10-19(25-13-20-26-11-16(31-5)12-27-20)22-21(28-18)15(4)29-30(22)14(2)3/h7-12,14H,6,13H2,1-5H3,(H,25,28) NLZDQEYNQWGPGP-UHFFFAOYSA-N 279145 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(5-methoxypyrimidin-2-yl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 176::US10512632, Example 176::US10766893, Example S176::US10806718, Example 176::US11026923, Example 176::US11491140, Example 176::US11634416, Example 176 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 81.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279145&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273468 378160725 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967663 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1ccc[nH]c1=O InChI=1S/C20H23N7O/c1-12(2)27-19-17(22-9-14-10-23-26(4)11-14)8-16(24-18(19)13(3)25-27)15-6-5-7-21-20(15)28/h5-8,10-12H,9H2,1-4H3,(H,21,28)(H,22,24) ZZXWQIDOSVIHIM-UHFFFAOYSA-N 279146 3-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]-1H-pyridin-2-one::US10034861, Example 177::US10512632, Example 177::US10766893, Example S177::US10806718, Example 177::US11026923, Example 177::US11491140, Example 177::US11634416, Example 177 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 130 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279146&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 136214893 378160726 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967666 CCOc1ncccc1-c1cc(NCc2cccnc2C(F)F)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H26F2N6O/c1-5-33-24-17(9-7-11-28-24)18-12-19(22-20(30-18)15(4)31-32(22)14(2)3)29-13-16-8-6-10-27-21(16)23(25)26/h6-12,14,23H,5,13H2,1-4H3,(H,29,30) IRSHUSVLDQPATB-UHFFFAOYSA-N 279147 N-[[2-(difluoromethyl)-3-pyridyl]methyl]-5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 178::US10512632, Example 178::US10766893, Example S178::US10806718, Example 178::US11026923, Example 178::US11491140, Example 178::US11634416, Example 178 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 31.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279147&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273469 378160727 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967669 CCOc1ncccc1-c1cc(NCc2cc(OC)ncn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O2/c1-6-32-23-17(8-7-9-24-23)18-11-19(25-12-16-10-20(31-5)27-13-26-16)22-21(28-18)15(4)29-30(22)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,25,28) RTCQCKBUFIYEDZ-UHFFFAOYSA-N 279148 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(6-methoxypyrimidin-4-yl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 179::US10512632, Example 179::US10766893, Example S179::US10806718, Example 179::US11026923, Example 179::US11491140, Example 179::US11634416, Example 179 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.80 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279148&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273471 378160728 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967672 CCOc1ncccc1-c1cc(NCc2cccnc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(10-8-12-26-24)19-13-20(27-14-17-9-7-11-25-23(17)31-5)22-21(28-19)16(4)29-30(22)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) LOZUTDKVJLMDTB-UHFFFAOYSA-N 279055 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 172::US10034861, Example 180::US10034861, Example 181::US10034861, Example 182::US10034861, Example 86::US10512632, Example 86::US10766893, Example S86::US10806718, Example 182::US11026923, Example 182::US11491140, Example 86::US11634416, Example 86 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 27.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279055&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273386 378160643 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967675 CCOc1ncccc1-c1cc(NCc2cccnc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(10-8-12-26-24)19-13-20(27-14-17-9-7-11-25-23(17)31-5)22-21(28-19)16(4)29-30(22)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) LOZUTDKVJLMDTB-UHFFFAOYSA-N 279055 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 172::US10034861, Example 180::US10034861, Example 181::US10034861, Example 182::US10034861, Example 86::US10512632, Example 86::US10766893, Example S86::US10806718, Example 182::US11026923, Example 182::US11491140, Example 86::US11634416, Example 86 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 31.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279055&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273386 378160643 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967678 CCOc1ncccc1-c1cc(NCc2cccnc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(10-8-12-26-24)19-13-20(27-14-17-9-7-11-25-23(17)31-5)22-21(28-19)16(4)29-30(22)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) LOZUTDKVJLMDTB-UHFFFAOYSA-N 279055 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 172::US10034861, Example 180::US10034861, Example 181::US10034861, Example 182::US10034861, Example 86::US10512632, Example 86::US10766893, Example S86::US10806718, Example 182::US11026923, Example 182::US11491140, Example 86::US11634416, Example 86 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 24.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279055&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273386 378160643 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967681 COc1ncccc1CNc1cc(nc2c(C)nn(C(C)C)c12)-c1cccnc1C(F)(F)F InChI=1S/C23H23F3N6O/c1-13(2)32-20-18(29-12-15-7-5-10-28-22(15)33-4)11-17(30-19(20)14(3)31-32)16-8-6-9-27-21(16)23(24,25)26/h5-11,13H,12H2,1-4H3,(H,29,30) AAAZUNCZBZHDPM-UHFFFAOYSA-N 279152 1-isopropyl-N-((2-methoxypyridin-3-yl)methyl)-3-methyl-5-(2-(trifluoromethyl)pyridin-3-yl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 183::US10512632, Example 183::US10766893, Example S183::US10806718, Example 183::US11634416, Example 183 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 290 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279152&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273472 378160729 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967684 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C(F)F)c2n1)C(C)C InChI=1S/C22H25F2N7O/c1-5-32-22-15(7-6-8-25-22)16-9-17(26-10-14-11-27-30(4)12-14)20-18(28-16)19(21(23)24)29-31(20)13(2)3/h6-9,11-13,21H,5,10H2,1-4H3,(H,26,28) YFAHCXPQQYYPCW-UHFFFAOYSA-N 279153 3-(difluoromethyl)-5-(2-ethoxypyridin-3-yl)-1-isopropyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 184::US10512632, Example 184::US10618913, Example S184::US10766893, Example S184::US10806718, Example 184::US11491140, Example 184::US11634416, Example 184 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 13.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279153&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273473 378160730 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967687 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-n1cncn1 InChI=1S/C17H21N9/c1-11(2)26-17-14(19-6-13-7-20-24(4)8-13)5-15(25-10-18-9-21-25)22-16(17)12(3)23-26/h5,7-11H,6H2,1-4H3,(H,19,22) VELNJFTUSCXPKE-UHFFFAOYSA-N 279154 1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-5-(1H-1,2,4-triazol-1-yl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 185::US10512632, Example 185::US10766893, Example S185::US10806718, Example 185::US11026923, Example 185::US11491140, Example 185::US11634416, Example 185 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 100.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279154&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273474 378160731 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967690 CC(C)n1nc(C)c2nc(cc(NCc3ncn(C)n3)c12)-c1ccc[nH]c1=O InChI=1S/C19H22N8O/c1-11(2)27-18-15(21-9-16-22-10-26(4)25-16)8-14(23-17(18)12(3)24-27)13-6-5-7-20-19(13)28/h5-8,10-11H,9H2,1-4H3,(H,20,28)(H,21,23) LRKYMHYCQWOGDT-UHFFFAOYSA-N 279155 3-[1-isopropyl-3-methyl-7-[(1-methyl-1,2,4-triazol-3-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]-1H-pyridin-2-one::US10034861, Example 186::US10512632, Example 186::US10766893, Example S186::US10806718, Example 186::US11026923, Example 186::US11491140, Example 186::US11634416, Example 186 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 64.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279155&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 136214894 378160732 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967693 CC(C)n1nc(C)c2nc(cc(NCc3cc[nH]n3)c12)-c1ccc[nH]c1=O InChI=1S/C19H21N7O/c1-11(2)26-18-16(21-10-13-6-8-22-24-13)9-15(23-17(18)12(3)25-26)14-5-4-7-20-19(14)27/h4-9,11H,10H2,1-3H3,(H,20,27)(H,21,23)(H,22,24) FWAXXZSYYYRIBS-UHFFFAOYSA-N 279156 3-[1-isopropyl-3-methyl-7-(1H-pyrazol-3-ylmethylamino)pyrazolo[4,3-b]pyridin-5-yl]-1H-pyridin-2-one::US10034861, Example 187::US10512632, Example 187::US10766893, Example S187::US10806718, Example 187::US11026923, Example 187::US11491140, Example 187::US11634416, Example 187 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 140 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279156&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 136214895 378160733 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967696 COc1cnccc1CNc1cc(nc2c(C)nn(C(C)C)c12)-c1cccnc1OC(F)F InChI=1S/C23H24F2N6O2/c1-13(2)31-21-18(28-11-15-7-9-26-12-19(15)32-4)10-17(29-20(21)14(3)30-31)16-6-5-8-27-22(16)33-23(24)25/h5-10,12-13,23H,11H2,1-4H3,(H,28,29) JCYRNKHSJQOBEI-UHFFFAOYSA-N 468500 5-[2-(difluoromethoxy)-3-pyridyl]-1-isopropyl- N-[(2-methoxy-3-pyridyl)methyl]-3-methyl- pyrazolo[4,3-b]pyridin-7-amine::US10806718, Example 188 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 61.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=468500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=468500&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 146593926 441570601 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967699 CCOc1ncccc1-c1cc(NCc2nccc(OC)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O2/c1-6-32-23-16(8-7-10-25-23)17-12-18(26-13-19-24-11-9-20(28-19)31-5)22-21(27-17)15(4)29-30(22)14(2)3/h7-12,14H,6,13H2,1-5H3,(H,26,27) ZRCQWXKCYCHOGM-UHFFFAOYSA-N 279158 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(4-methoxypyrimidin-2-yl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 189::US10512632, Example 189::US10766893, Example S189::US10806718, Example 189::US11026923, Example 189::US11491140, Example 189::US11634416, Example 189 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 3.90 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279158&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273477 378160735 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967702 CCOc1ncccc1-c1cc(NCc2cncnc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O2/c1-6-32-23-17(8-7-9-25-23)18-10-19(26-12-16-11-24-13-27-22(16)31-5)21-20(28-18)15(4)29-30(21)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,26,28) FQSCOMBJMAVYMG-UHFFFAOYSA-N 279159 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(4-methoxypyrimidin-5-yl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 190::US10512632, Example 190::US10766893, Example S190::US10806718, Example 190::US11026923, Example 190::US11491140, Example 190::US11634416, Example 190 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 74.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279159&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273480 378160736 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967705 CCOc1ncccc1CNc1cc(nc2c(C)nn(C(C)C)c12)-c1cccnc1OCC InChI=1S/C25H30N6O2/c1-6-32-24-18(10-8-12-26-24)15-28-21-14-20(19-11-9-13-27-25(19)33-7-2)29-22-17(5)30-31(16(3)4)23(21)22/h8-14,16H,6-7,15H2,1-5H3,(H,28,29) RPFGIRQWMRKNBU-UHFFFAOYSA-N 279160 5-(2-ethoxy-3-pyridyl)-N-[(2-ethoxy-3-pyridyl)methyl]-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 191::US10512632, Example 191::US10766893, Example S191::US10806718, Example 191::US11026923, Example 191::US11491140, Example 191::US11634416, Example 191 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 160 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279160&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273479 378160737 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967708 COc1ccc(CNc2cc(nc3c(C)nn(C(C)C)c23)-c2cccnc2N(C)C)cc1 InChI=1S/C25H30N6O/c1-16(2)31-24-22(27-15-18-9-11-19(32-6)12-10-18)14-21(28-23(24)17(3)29-31)20-8-7-13-26-25(20)30(4)5/h7-14,16H,15H2,1-6H3,(H,27,28) RMYFPLHNAGFJMC-UHFFFAOYSA-N 279161 5-[2-(dimethylamino)-3-pyridyl]-1-isopropyl-N-[(4-methoxyphenyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 192::US10512632, Example 192::US10766893, Example S192::US10806718, Example 192::US11026923, Example 192::US11491140, Example 192::US11634416, Example 192 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 630 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279161&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273481 378160738 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967711 CC(C)n1nc(C)c2nc(cc(NCc3cccnc3C(F)(F)F)c12)-c1ccc[nH]c1=O InChI=1S/C22H21F3N6O/c1-12(2)31-19-17(28-11-14-6-4-8-26-20(14)22(23,24)25)10-16(29-18(19)13(3)30-31)15-7-5-9-27-21(15)32/h4-10,12H,11H2,1-3H3,(H,27,32)(H,28,29) CEASKHHYUJNGEA-UHFFFAOYSA-N 279162 3-[1-isopropyl-3-methyl-7-[[2-(trifluoromethyl)-3-pyridyl]methylamino]pyrazolo[4,3-b]pyridin-5-yl]-1H-pyridin-2-one::US10034861, Example 193::US10512632, Example 193::US10766893, Example S193::US10806718, Example 193::US11491140, Example 193::US11634416, Example 193 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 320 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279162&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 136214896 378160739 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967714 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1conc1C InChI=1S/C19H23N7O/c1-11(2)26-19-17(20-7-14-8-21-25(5)9-14)6-16(15-10-27-24-12(15)3)22-18(19)13(4)23-26/h6,8-11H,7H2,1-5H3,(H,20,22) MTWLSLCQXJXQNM-UHFFFAOYSA-N 279163 1-isopropyl-3-methyl-5-(3-methylisoxazol-4-yl)-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 194::US10512632, Example 194::US10766893, Example S194::US10806718, Example 194::US11491140, Example 194::US11634416, Example 194 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 95.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279163&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273485 378160740 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967717 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1ncnn1C InChI=1S/C18H23N9/c1-11(2)27-17-14(19-7-13-8-21-25(4)9-13)6-15(18-20-10-22-26(18)5)23-16(17)12(3)24-27/h6,8-11H,7H2,1-5H3,(H,19,23) KYLSIDIKSXHHCI-UHFFFAOYSA-N 279164 1-isopropyl-3-methyl-5-(1-methyl-1H-1,2,4-triazol-5-yl)-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 195::US10512632, Example 195::US10618913, Example S195::US10766893, Example S195::US10806718, Example 195::US11026923, Example 195::US11634416, Example 195 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 420 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279164&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273486 378160741 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967720 CCCOc1ccccc1-c1cc(NCc2cn[nH]c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H28N6O/c1-5-10-30-21-9-7-6-8-18(21)19-11-20(24-12-17-13-25-26-14-17)23-22(27-19)16(4)28-29(23)15(2)3/h6-9,11,13-15H,5,10,12H2,1-4H3,(H,24,27)(H,25,26) MXRHKEUIFABQMB-UHFFFAOYSA-N 468508 1-isopropyl-3-methyl-5-(2-propoxy-3-pyridyl)- N-(1H-pyrazol-4-ylmethyl)pyrazolo[4,3- b]pyridin-7-amine::US10806718, Example 196 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 18.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=468508 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=468508&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 155921701 441570609 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967723 CCOc1ncccc1-c1cc(NCc2cccnc2OC)c2n(nc(C)c2n1)C1COC1 InChI=1S/C24H26N6O3/c1-4-33-24-18(8-6-10-26-24)19-11-20(27-12-16-7-5-9-25-23(16)31-3)22-21(28-19)15(2)29-30(22)17-13-32-14-17/h5-11,17H,4,12-14H2,1-3H3,(H,27,28) GRFJYHDUOKDAKO-UHFFFAOYSA-N 279166 5-(2-ethoxy-3-pyridyl)-N-[(2-methoxy-3-pyridyl)methyl]-3-methyl-1-(oxetan-3-yl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 197::US10512632, Example 197::US10618913, Example S197::US10766893, Example S197::US10806718, Example 197::US11491140, Example 197::US11634416, Example 197 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 190 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279166&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273484 378160743 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967726 CCN(C)c1ncccc1-c1cc(NCc2ccc(OC)cc2)c2n(nc(C)c2n1)C(C)C InChI=1S/C26H32N6O/c1-7-31(5)26-21(9-8-14-27-26)22-15-23(28-16-19-10-12-20(33-6)13-11-19)25-24(29-22)18(4)30-32(25)17(2)3/h8-15,17H,7,16H2,1-6H3,(H,28,29) YNHQWVLFISTQIU-UHFFFAOYSA-N 279167 5-(2-(ethyl(methyl)amino)pyridin-3-yl)-1-isopropyl-N-(4-methoxybenzyl)-3-methyl-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 198::US10512632, Example 198::US10766893, Example S198::US10806718, Example 198::US11026923, Example 198::US11491140, Example 198::US11634416, Example 198 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1100 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279167 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279167&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273483 378160744 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967729 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(CF)c2n1)C(C)C InChI=1S/C22H26FN7O/c1-5-31-22-16(7-6-8-24-22)17-9-18(25-11-15-12-26-29(4)13-15)21-20(27-17)19(10-23)28-30(21)14(2)3/h6-9,12-14H,5,10-11H2,1-4H3,(H,25,27) CRFWOMGBISLKHY-UHFFFAOYSA-N 279168 5-(2-ethoxypyridin-3-yl)-3-(fluoromethyl)-1-isopropyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 199::US10512632, Example 199::US10618913, Example S199::US10766893, Example S199::US10806718, Example 199::US11026923, Example 199::US11491140, Example 199::US11634416, Example 199 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 7.40 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279168&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273487 378160745 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967732 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1ocnc1C InChI=1S/C19H23N7O/c1-11(2)26-18-15(20-7-14-8-22-25(5)9-14)6-16(19-13(4)21-10-27-19)23-17(18)12(3)24-26/h6,8-11H,7H2,1-5H3,(H,20,23) JVGYDVFOXCBHRN-UHFFFAOYSA-N 279169 1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-5-(4-methyloxazol-5-yl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 200::US10512632, Example 200::US10618913, Example S200::US10766893, Example S200::US10806718, Example 200::US11026923, Example 200::US11491140, Example 200::US11634416, Example 200 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 98.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279169&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273489 378160746 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967735 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1cccnc1N(C)C InChI=1S/C22H28N8/c1-14(2)30-21-19(24-11-16-12-25-29(6)13-16)10-18(26-20(21)15(3)27-30)17-8-7-9-23-22(17)28(4)5/h7-10,12-14H,11H2,1-6H3,(H,24,26) JWSSTJTVRAZILB-UHFFFAOYSA-N 279170 5-[2-(dimethylamino)-3-pyridyl]-1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 201::US10512632, Example 201::US10766893, Example S201::US10806718, Example 201::US11026923, Example 201::US11491140, Example 201::US11634416, Example 201 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2100 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279170&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273490 378160747 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967738 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1nc(C)co1 InChI=1S/C19H23N7O/c1-11(2)26-18-15(20-7-14-8-21-25(5)9-14)6-16(19-22-12(3)10-27-19)23-17(18)13(4)24-26/h6,8-11H,7H2,1-5H3,(H,20,23) GNUZZRWHGHQDMA-UHFFFAOYSA-N 279171 1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-5-(4-methyloxazol-2-yl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 202::US10512632, Example 202::US10766893, Example S202::US10806718, Example 202::US11634416, Example 202 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 92.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279171&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273491 378160748 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967741 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1nncn1C InChI=1S/C18H23N9/c1-11(2)27-17-14(19-7-13-8-21-26(5)9-13)6-15(18-23-20-10-25(18)4)22-16(17)12(3)24-27/h6,8-11H,7H2,1-5H3,(H,19,22) KAIFDCSXZCWWKF-UHFFFAOYSA-N 279172 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-(4-methyl-1,2,4-triazol-3-::US10034861, Example 203::US10512632, Example 203::US10766893, Example S203::US10806718, Example 203::US11026923, Example 203::US11491140, Example 203::US11634416, Example 203 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 410 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279172 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279172&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273492 378160749 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967142 CCOc1ncccc1-c1cc(NCc2ncc(C)s2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6OS/c1-6-29-22-16(8-7-9-23-22)17-10-18(24-12-19-25-11-14(4)30-19)21-20(26-17)15(5)27-28(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,24,26) QOYNQFLWGDTXKT-UHFFFAOYSA-N 278972 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methylthiazol-2-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 2::US10512632, Example 2::US10766893, Example S2::US10806718, Example 2::US11026923, Example 2::US11491140, Example 2::US11634416, Example 2 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.460 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278972 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278972&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273301 378160561 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967145 CCOc1ncccc1-c1cc(NCc2cc(C)on2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6O2/c1-6-29-22-17(8-7-9-23-22)18-11-19(24-12-16-10-14(4)30-27-16)21-20(25-18)15(5)26-28(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,24,25) MKELJWFWEJOZNC-UHFFFAOYSA-N 278973 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methylisoxazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 3::US10512632, Example 3::US10766893, Example S3::US10806718, Example 3::US11026923, Example 3::US11491140, Example 3::US11634416, Example 3 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.800 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278973&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273302 378160562 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967148 CCOc1ncccc1-c1cc(NCc2cnc(C)o2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6O2/c1-6-29-22-17(8-7-9-23-22)18-10-19(25-12-16-11-24-15(5)30-16)21-20(26-18)14(4)27-28(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,25,26) TWDRBTLHNZMOLP-UHFFFAOYSA-N 278974 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methyloxazol-5-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 4::US10512632, Example 4::US10766893, Example S4::US10806718, Example 4::US11026923, Example 4::US11491140, Example 4::US11634416, Example 4 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.60 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278974 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278974&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273304 378160563 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967151 CCOc1ncccc1-c1cc(NCc2cnn(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-6-30-21-16(8-7-9-22-21)17-10-18(23-11-15-12-24-28(5)27-15)20-19(25-17)14(4)26-29(20)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,23,25) RKVBYUMNPKGITG-UHFFFAOYSA-N 278975 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methyltriazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 5::US10512632, Example 5::US10766893, Example S5::US10806718, Example 5::US11026923, Example 5::US11491140, Example 5::US11634416, Example 5 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 11.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278975&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273303 378160564 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967154 CCOc1ncccc1-c1cc(NCc2cn(C)nn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-6-30-21-16(8-7-9-22-21)17-10-18(23-11-15-12-28(5)27-25-15)20-19(24-17)14(4)26-29(20)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,23,24) GZZVSCZGHCUFQG-UHFFFAOYSA-N 278976 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(1-methyltriazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 6::US10512632, Example 6::US10766893, Example S6::US10806718, Example 6::US11026923, Example 6::US11491140, Example 6::US11634416, Example 6 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4.80 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278976&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273306 378160565 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967157 CCOc1ncccc1-c1cc(NCc2cn[nH]c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H25N7O/c1-5-29-21-16(7-6-8-22-21)17-9-18(23-10-15-11-24-25-12-15)20-19(26-17)14(4)27-28(20)13(2)3/h6-9,11-13H,5,10H2,1-4H3,(H,23,26)(H,24,25) ZBYZXMQLZZULRF-UHFFFAOYSA-N 278977 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1H-pyrazol-4-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 7::US10512632, Example 7::US10766893, Example S7::US10806718, Example 7::US11026923, Example 7::US11491140, Example 7::US11634416, Example 7 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 21.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278977 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278977&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 136214891 378160566 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967160 CCOc1ncccc1-c1cc(NCc2nnn(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C20H25N9O/c1-6-30-20-14(8-7-9-21-20)15-10-16(22-11-17-24-27-28(5)26-17)19-18(23-15)13(4)25-29(19)12(2)3/h7-10,12H,6,11H2,1-5H3,(H,22,23) MMFBNAADCPOKBP-UHFFFAOYSA-N 278978 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methyltetrazol-5-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 8::US10512632, Example 8::US10766893, Example S8::US10806718, Example 8::US11491140, Example 8::US11634416, Example 8 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.90 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278978&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273308 378160567 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967163 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H27N7O/c1-6-30-22-17(8-7-9-23-22)18-10-19(24-11-16-12-25-28(5)13-16)21-20(26-18)15(4)27-29(21)14(2)3/h7-10,12-14H,6,11H2,1-5H3,(H,24,26) IGZQEXMDAKABFO-UHFFFAOYSA-N 278979 5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 9::US10512632, Example 9::US10766893, Example S9::US10806718, Example 9::US11491140, Example 9::US11634416, Example 9 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.60 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278979&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273307 378160568 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967166 CCOc1ncccc1-c1cc(NCc2cc(C)no2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6O2/c1-6-29-22-17(8-7-9-23-22)18-11-19(24-12-16-10-14(4)27-30-16)21-20(25-18)15(5)26-28(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,24,25) WAUSGEZRVANNBG-UHFFFAOYSA-N 278980 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(3-methylisoxazol-5-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 10::US10512632, Example 10::US10766893, Example S10::US10806718, Example 10::US11491140, Example 10::US11634416, Example 10 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4.10 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278980 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278980&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273310 378160569 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967169 CCOc1ncccc1-c1cc(NCc2csc(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6OS/c1-6-29-22-17(8-7-9-23-22)18-10-19(24-11-16-12-30-15(5)25-16)21-20(26-18)14(4)27-28(21)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,24,26) YDCVOKZJZPJMKM-UHFFFAOYSA-N 278981 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methylthiazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 11::US10512632, Example 11::US10766893, Example S11::US10806718, Example 11::US11491140, Example 11::US11634416, Example 11 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 9.60 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278981&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273309 378160570 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967172 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C1CC1 InChI=1S/C22H25N7O/c1-4-30-22-17(6-5-9-23-22)18-10-19(24-11-15-12-25-28(3)13-15)21-20(26-18)14(2)27-29(21)16-7-8-16/h5-6,9-10,12-13,16H,4,7-8,11H2,1-3H3,(H,24,26) SVNBZNOJEMDHHP-UHFFFAOYSA-N 278982 1-cyclopropyl-5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 12::US10512632, Example 12::US10618913, Example S12::US10766893, Example S12::US10806718, Example 12::US11026923, Example 12::US11491140, Example 12 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 200 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278982&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273311 378160571 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967175 CCCn1ncc2nc(cc(NCc3cnn(C)c3)c12)-c1cccnc1OCC InChI=1S/C21H25N7O/c1-4-9-28-20-18(23-11-15-12-24-27(3)14-15)10-17(26-19(20)13-25-28)16-7-6-8-22-21(16)29-5-2/h6-8,10,12-14H,4-5,9,11H2,1-3H3,(H,23,26) VBBYLKGVLRZVDT-UHFFFAOYSA-N 278983 5-(2-ethoxy-3-pyridyl)-N-[(1-methylpyrazol-4-yl)methyl]-1-propyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 13::US10512632, Example 13::US10618913, Example S13::US10766893, Example S13::US10806718, Example 13::US11026923, Example 13::US11491140, Example 13::US11634416, Example 13 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 90.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278983 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278983&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273312 378160572 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967178 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(ncc2n1)C1COC1 InChI=1S/C21H23N7O2/c1-3-30-21-16(5-4-6-22-21)17-7-18(23-8-14-9-24-27(2)11-14)20-19(26-17)10-25-28(20)15-12-29-13-15/h4-7,9-11,15H,3,8,12-13H2,1-2H3,(H,23,26) BRAWZTIBDHEBNS-UHFFFAOYSA-N 278984 5-(2-ethoxypyridin-3-yl)-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1-(oxetan-3-yl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 14::US10512632, Example 14::US10618913, Example S14::US10766893, Example S14::US10806718, Example 14::US11026923, Example 14::US11491140, Example 14::US11634416, Example 14 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 450 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278984 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278984&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273313 378160573 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967181 CCOc1ncccc1-c1cc(NC(C)c2cnn(C)c2)c2n(C)ncc2n1 InChI=1S/C20H23N7O/c1-5-28-20-15(7-6-8-21-20)16-9-17(19-18(25-16)11-23-27(19)4)24-13(2)14-10-22-26(3)12-14/h6-13H,5H2,1-4H3,(H,24,25) PRZKTPKTSVRPRD-UHFFFAOYSA-N 278985 5-(2-ethoxypyridin-3-yl)-1-methyl-N-(1-(1-methyl-1H-pyrazol-4-yl)ethyl)-1H-pyrazolo[4,3-b]pyridin-7-amine (racemic)::US10034861, Example 15::US10766893, Example S15::US10806718, Example 15::US11026923, Example 15::US11491140, Example 15 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 820 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278985 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278985&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273314 378160574 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967183 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(C)ncc2n1 InChI=1S/C19H21N7O/c1-4-27-19-14(6-5-7-20-19)15-8-16(18-17(24-15)11-23-26(18)3)21-9-13-10-22-25(2)12-13/h5-8,10-12H,4,9H2,1-3H3,(H,21,24) IHPVHEUBCHVJEQ-UHFFFAOYSA-N 278986 5-(2-ethoxypyridin-3-yl)-1-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 16::US10512632, Example 16::US10766893, Example S16::US10806718, Example 16::US11026923, Example 16::US11491140, Example 16 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 670 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278986&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273315 378160575 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967186 CCOc1ncccc1-c1cc(NCc2nccn2C)c2n(ncc2n1)C(C)C InChI=1S/C21H25N7O/c1-5-29-21-15(7-6-8-23-21)16-11-17(24-13-19-22-9-10-27(19)4)20-18(26-16)12-25-28(20)14(2)3/h6-12,14H,5,13H2,1-4H3,(H,24,26) XRIYYPDCPKIHRW-UHFFFAOYSA-N 278987 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimidazol-2-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 17::US10512632, Example 17::US10618913, Example S17::US10766893, Example S17::US10806718, Example 17::US11026923, Example 17::US11491140, Example 17::US11634416, Example 17 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 700 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278987 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278987&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273316 378160576 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967189 CCOc1ncccc1-c1cc(NCc2ccnn2C)c2n(ncc2n1)C(C)C InChI=1S/C21H25N7O/c1-5-29-21-16(7-6-9-22-21)17-11-18(23-12-15-8-10-24-27(15)4)20-19(26-17)13-25-28(20)14(2)3/h6-11,13-14H,5,12H2,1-4H3,(H,23,26) ARZYUJKMHFQSRW-UHFFFAOYSA-N 278988 5-(2-ethoxypyridin-3-yl)-1-isopropyl-N-((1-methyl-1H-pyrazol-5-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 18::US10512632, Example 18::US10766893, Example S18::US10806718, Example 18::US11026923, Example 18::US11491140, Example 18::US11634416, Example 18 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 450 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278988&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273317 378160577 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967192 CCOc1ncccc1-c1cc(NCc2ccn(C)n2)c2n(ncc2n1)C(C)C InChI=1S/C21H25N7O/c1-5-29-21-16(7-6-9-22-21)17-11-18(23-12-15-8-10-27(4)26-15)20-19(25-17)13-24-28(20)14(2)3/h6-11,13-14H,5,12H2,1-4H3,(H,23,25) KZFYUJZMDBTCDC-UHFFFAOYSA-N 278989 5-(2-ethoxypyridin-3-yl)-1-isopropyl-N-((1-methyl-1H-pyrazol-3-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 19::US10512632, Example 19::US10766893, Example S19::US10806718, Example 19::US11026923, Example 19::US11491140, Example 19::US11634416, Example 19 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 66.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278989 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278989&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273318 378160578 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967195 CCOc1ncccc1-c1cc(NCc2nccs2)c2n(ncc2n1)C(C)C InChI=1S/C20H22N6OS/c1-4-27-20-14(6-5-7-22-20)15-10-16(23-12-18-21-8-9-28-18)19-17(25-15)11-24-26(19)13(2)3/h5-11,13H,4,12H2,1-3H3,(H,23,25) ICTYYJZHJNSZFG-UHFFFAOYSA-N 278990 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-(thiazol-2-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 20::US10512632, Example 20::US10766893, Example S20::US10806718, Example 20::US11026923, Example 20::US11491140, Example 20::US11634416, Example 20 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 520 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278990&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273319 378160579 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967198 CCOc1ncccc1-c1cc(NCc2cn(C)cn2)c2n(ncc2n1)C(C)C InChI=1S/C21H25N7O/c1-5-29-21-16(7-6-8-22-21)17-9-18(23-10-15-12-27(4)13-24-15)20-19(26-17)11-25-28(20)14(2)3/h6-9,11-14H,5,10H2,1-4H3,(H,23,26) GPZPPQFWVLHHBU-UHFFFAOYSA-N 278991 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimidazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 21::US10512632, Example 21::US10766893, Example S21::US10806718, Example 21::US11026923, Example 21::US11491140, Example 21::US11634416, Example 21 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.90 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278991&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273320 378160580 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967201 CCOc1ncccc1-c1cc(NCc2ccncc2)c2n(ncc2n1)C(C)C InChI=1S/C22H24N6O/c1-4-29-22-17(6-5-9-24-22)18-12-19(25-13-16-7-10-23-11-8-16)21-20(27-18)14-26-28(21)15(2)3/h5-12,14-15H,4,13H2,1-3H3,(H,25,27) HEERUKANWGHTOL-UHFFFAOYSA-N 278992 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-(4-pyridylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 22::US10512632, Example 22::US10766893, Example S22::US10806718, Example 22::US11026923, Example 22::US11491140, Example 22::US11634416, Example 22 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 250 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278992&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273322 378160581 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967204 CCOc1ncccc1-c1cc(NCc2cccc(C)c2)c2n(ncc2n1)C(C)C InChI=1S/C24H27N5O/c1-5-30-24-19(10-7-11-25-24)20-13-21(26-14-18-9-6-8-17(4)12-18)23-22(28-20)15-27-29(23)16(2)3/h6-13,15-16H,5,14H2,1-4H3,(H,26,28) NOGPVEPEDSPNHF-UHFFFAOYSA-N 278993 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-(m-tolylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 23::US10512632, Example 23::US10618913, Example S23::US10766893, Example S23::US10806718, Example 23::US11026923, Example 23::US11491140, Example 23::US11634416, Example 23 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 240 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278993&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273321 378160582 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967207 CCOc1ncccc1-c1cc(NCc2ccc(C)cc2)c2n(ncc2n1)C(C)C InChI=1S/C24H27N5O/c1-5-30-24-19(7-6-12-25-24)20-13-21(26-14-18-10-8-17(4)9-11-18)23-22(28-20)15-27-29(23)16(2)3/h6-13,15-16H,5,14H2,1-4H3,(H,26,28) KLXXAXDPPNWJOU-UHFFFAOYSA-N 278994 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-(p-tolylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 24::US10512632, Example 24::US10766893, Example S24::US10806718, Example 24::US11026923, Example 24::US11491140, Example 24::US11634416, Example 24 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 380 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278994&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273323 378160583 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967210 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(ncc2n1)C(C)C InChI=1S/C21H25N7O/c1-5-29-21-16(7-6-8-22-21)17-9-18(23-10-15-11-24-27(4)13-15)20-19(26-17)12-25-28(20)14(2)3/h6-9,11-14H,5,10H2,1-4H3,(H,23,26) PLERDTYSXFBCOL-UHFFFAOYSA-N 278995 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 25::US10512632, Example 25::US10766893, Example S25::US10806718, Example 25::US11026923, Example 25::US11491140, Example 25::US11634416, Example 25 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 56.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278995&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273324 378160584 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967213 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(CC)ncc2n1 InChI=1S/C20H23N7O/c1-4-27-19-17(22-10-14-11-23-26(3)13-14)9-16(25-18(19)12-24-27)15-7-6-8-21-20(15)28-5-2/h6-9,11-13H,4-5,10H2,1-3H3,(H,22,25) GDQVLYVPAWKIKI-UHFFFAOYSA-N 424936 US10512632, Example 26::US10618913, Example S26::US10766893, Example S26::US10806718, Example 26::US11026923, Example 26::US11491140, Example 26::US11634416, Example 26 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 140 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=424936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=424936&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138536209 434150491 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967216 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C1COC1 InChI=1S/C22H25N7O2/c1-4-31-22-17(6-5-7-23-22)18-8-19(24-9-15-10-25-28(3)11-15)21-20(26-18)14(2)27-29(21)16-12-30-13-16/h5-8,10-11,16H,4,9,12-13H2,1-3H3,(H,24,26) HKTCICUQHUTDJM-UHFFFAOYSA-N 278997 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-1-(oxetan-3-yl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 27::US10512632, Example 27::US10766893, Example S27::US10806718, Example 27::US11026923, Example 27::US11491140, Example 27::US11634416, Example 27 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 94.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278997 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278997&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273326 378160586 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967219 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(C)nc(C)c2n1 InChI=1S/C20H23N7O/c1-5-28-20-15(7-6-8-21-20)16-9-17(22-10-14-11-23-26(3)12-14)19-18(24-16)13(2)25-27(19)4/h6-9,11-12H,5,10H2,1-4H3,(H,22,24) GGQMHLLGYDUHDQ-UHFFFAOYSA-N 278998 5-(2-ethoxy-3-pyridyl)-1,3-dimethyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 28::US10512632, Example 28::US10618913, Example S28::US10766893, Example S28::US10806718, Example 28::US11026923, Example 28::US11491140, Example 28::US11634416, Example 28 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 550 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278998 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278998&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273327 378160587 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967222 CCOc1ncccc1-c1cc(NCc2nc(C)cs2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6OS/c1-6-29-22-16(8-7-9-23-22)17-10-18(24-11-19-25-14(4)12-30-19)21-20(26-17)15(5)27-28(21)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,24,26) WFSFSRAGPIZNCC-UHFFFAOYSA-N 278999 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(4-methylthiazol-2-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 29::US10512632, Example 29::US10618913, Example S162::US10766893, Example S29::US10806718, Example 29::US11026923, Example 29::US11491140, Example 29::US11634416, Example 29 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 27.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278999 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278999&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273328 378160588 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967225 CCOc1ncccc1-c1cc(NCc2nc(C)no2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H25N7O2/c1-6-29-21-15(8-7-9-22-21)16-10-17(23-11-18-24-14(5)27-30-18)20-19(25-16)13(4)26-28(20)12(2)3/h7-10,12H,6,11H2,1-5H3,(H,23,25) ZPMKSBYSMXCOIZ-UHFFFAOYSA-N 279000 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(3-methyl-1,2,4-oxadiazol-5-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 30::US10512632, Example 30::US10766893, Example S30::US10806718, Example 30::US11026923, Example 30::US11491140, Example 30::US11634416, Example 30 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 15.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279000 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279000&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273329 378160589 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967228 CCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-6-30-21-15(8-7-9-22-21)16-10-17(23-11-18-24-12-28(5)27-18)20-19(25-16)14(4)26-29(20)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,23,25) CJOUFKUESMXTOX-UHFFFAOYSA-N 279001 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 161::US10034861, Example 31::US10512632, Example 31::US10766893, Example S31::US10806718, Example 31::US11026923, Example 31::US11491140, Example 31::US11634416, Example 31 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.20 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279001 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279001&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273330 378160590 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967231 CCOc1ncccc1-c1cc(NCc2cnc(C)s2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6OS/c1-6-29-22-17(8-7-9-23-22)18-10-19(25-12-16-11-24-15(5)30-16)21-20(26-18)14(4)27-28(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,25,26) UJFBEAPRUYBIKE-UHFFFAOYSA-N 279002 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methylthiazol-5-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 32::US10512632, Example 32::US10766893, Example S32::US10806718, Example 32::US11026923, Example 32::US11491140, Example 32::US11634416, Example 32 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4.60 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279002&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273331 378160591 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967234 CCOc1ncccc1-c1cc(NCc2nnc(C)s2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H25N7OS/c1-6-29-21-15(8-7-9-22-21)16-10-17(23-11-18-26-25-14(5)30-18)20-19(24-16)13(4)27-28(20)12(2)3/h7-10,12H,6,11H2,1-5H3,(H,23,24) XQUFGMNXDPCXMM-UHFFFAOYSA-N 279003 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methyl-1,3,4-thiadiazol-2-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 33::US10512632, Example 33::US10766893, Example S33::US10806718, Example 33::US11026923, Example 33::US11491140, Example 33::US11634416, Example 33 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.60 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279003 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279003&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273332 378160592 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967237 CCOc1ncccc1-c1cc(NCc2csc(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N5OS/c1-6-29-23-18(8-7-9-24-23)19-11-20(25-12-17-10-15(4)30-13-17)22-21(26-19)16(5)27-28(22)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,25,26) VNCLCBKVWWHCAF-UHFFFAOYSA-N 279004 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methyl-3-thienyl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 34::US10512632, Example 34::US10766893, Example S34::US10806718, Example 34::US11026923, Example 34::US11491140, Example 34::US11634416, Example 34 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.10 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279004 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279004&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273333 378160593 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967240 CCOc1ncccc1-c1cc(NCc2cc(C)cs2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N5OS/c1-6-29-23-18(8-7-9-24-23)19-11-20(25-12-17-10-15(4)13-30-17)22-21(26-19)16(5)27-28(22)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,25,26) DHODKXCCORNYHA-UHFFFAOYSA-N 279005 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(4-methyl-2-thienyl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 35::US10512632, Example 35::US10766893, Example S35::US10806718, Example 35::US11026923, Example 35::US11491140, Example 35::US11634416, Example 35 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 7.30 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279005 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279005&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273334 378160594 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967243 CCOc1ncccc1-c1cc(NCc2ccc(C)s2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N5OS/c1-6-29-23-18(8-7-11-24-23)19-12-20(25-13-17-10-9-15(4)30-17)22-21(26-19)16(5)27-28(22)14(2)3/h7-12,14H,6,13H2,1-5H3,(H,25,26) MXNGXYQZCMFPJD-UHFFFAOYSA-N 279006 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methyl-2-thienyl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 36::US10512632, Example 36::US10766893, Example S36::US10806718, Example 36::US11026923, Example 36::US11491140, Example 36::US11634416, Example 36 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 24.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279006&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273337 378160595 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967246 CCOc1ncccc1-c1cc(NCc2coc(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6O2/c1-6-29-22-17(8-7-9-23-22)18-10-19(24-11-16-12-30-15(5)25-16)21-20(26-18)14(4)27-28(21)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,24,26) VZTGUNQMZSOPTA-UHFFFAOYSA-N 279007 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methyloxazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 37::US10512632, Example 37::US10766893, Example S37::US10806718, Example 37::US11026923, Example 37::US11491140, Example 37::US11634416, Example 37 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 5.90 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279007 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279007&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273335 378160596 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967249 CCOc1ncccc1-c1cc(NCc2ncc(C)o2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6O2/c1-6-29-22-16(8-7-9-23-22)17-10-18(24-12-19-25-11-14(4)30-19)21-20(26-17)15(5)27-28(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,24,26) IGMSFVIKHQRGSP-UHFFFAOYSA-N 279008 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methyloxazol-2-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 38::US10512632, Example 38::US10766893, Example S38::US10806718, Example 38::US11026923, Example 38::US11491140, Example 38::US11634416, Example 38 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.10 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279008 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279008&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273338 378160597 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967252 CCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H25N7O/c1-5-29-21-16(7-6-9-22-21)17-11-18(23-12-15-8-10-24-26-15)20-19(25-17)14(4)27-28(20)13(2)3/h6-11,13H,5,12H2,1-4H3,(H,23,25)(H,24,26) UOWVOVPKNPTQQH-UHFFFAOYSA-N 279009 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 39::US10512632, Example 39::US10766893, Example S39::US10806718, Example 39::US11026923, Example 39::US11491140, Example 39::US11634416, Example 39 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.10 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279009 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279009&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273340 378160598 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967255 CCOc1ncccc1-c1cc(NCc2c[nH]cn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H25N7O/c1-5-29-21-16(7-6-8-23-21)17-9-18(24-11-15-10-22-12-25-15)20-19(26-17)14(4)27-28(20)13(2)3/h6-10,12-13H,5,11H2,1-4H3,(H,22,25)(H,24,26) IQIUSKXHLPBBOV-UHFFFAOYSA-N 279010 5-(2-ethoxy-3-pyridyl)-N-(1H-imidazol-4-ylmethyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 40::US10512632, Example 40::US10766893, Example S40::US10806718, Example 40::US11026923, Example 40::US11491140, Example 40::US11634416, Example 40 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 14.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279010 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279010&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273339 378160599 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967258 CCOc1ncccc1-c1cc(NCc2ccccc2)c2n(ncc2n1)C(C)C InChI=1S/C23H25N5O/c1-4-29-23-18(11-8-12-24-23)19-13-20(25-14-17-9-6-5-7-10-17)22-21(27-19)15-26-28(22)16(2)3/h5-13,15-16H,4,14H2,1-3H3,(H,25,27) CAHURFTWFHHOPU-UHFFFAOYSA-N 279011 N-benzyl-5-(2-ethoxy-3-pyridyl)-1-isopropyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 41::US10512632, Example 41::US10618913, Example S41::US10766893, Example S41::US10806718, Example 41::US11026923, Example 41::US11634416, Example 41 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 500 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279011 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279011&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273336 378160600 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967261 CCOc1ncccc1-c1cc(NCc2cc(C)no2)c2n(ncc2n1)C(C)C InChI=1S/C21H24N6O2/c1-5-28-21-16(7-6-8-22-21)17-10-18(23-11-15-9-14(4)26-29-15)20-19(25-17)12-24-27(20)13(2)3/h6-10,12-13H,5,11H2,1-4H3,(H,23,25) ZGFGKVRUAVJQMR-UHFFFAOYSA-N 279012 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(3-methylisoxazol-5-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 42::US10512632, Example 42::US10766893, Example S42::US10806718, Example 42::US11026923, Example 42::US11634416, Example 42 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 82.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279012&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273341 378160601 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967264 CCOc1ncccc1-c1cc(NCc2noc(C)n2)c2n(ncc2n1)C(C)C InChI=1S/C20H23N7O2/c1-5-28-20-14(7-6-8-21-20)15-9-16(22-11-18-24-13(4)29-26-18)19-17(25-15)10-23-27(19)12(2)3/h6-10,12H,5,11H2,1-4H3,(H,22,25) SDTZIRBETDMBLS-UHFFFAOYSA-N 279013 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 43::US10512632, Example 43::US10766893, Example S43::US10806718, Example 43::US11026923, Example 43::US11634416, Example 43 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 30.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279013&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273344 378160602 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967267 CCOc1ncccc1-c1cc(NCc2cc(C)n(C)n2)c2n(ncc2n1)C(C)C InChI=1S/C22H27N7O/c1-6-30-22-17(8-7-9-23-22)18-11-19(24-12-16-10-15(4)28(5)27-16)21-20(26-18)13-25-29(21)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,24,26) RWTZKAWRGHZQKR-UHFFFAOYSA-N 279014 N-[(1,5-dimethylpyrazol-3-yl)methyl]-5-(2-ethoxy-3-pyridyl)-1-isopropyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 44::US10512632, Example 44::US10766893, Example S44::US10806718, Example 44::US11026923, Example 44::US11634416, Example 44 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 19.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279014 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279014&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273342 378160603 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967270 CCOc1ncccc1-c1cc(NCc2ccc(=O)n(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(8-7-11-25-24)19-12-20(26-13-17-9-10-21(31)29(5)14-17)23-22(27-19)16(4)28-30(23)15(2)3/h7-12,14-15H,6,13H2,1-5H3,(H,26,27) IFSZKCSGKSFXTM-UHFFFAOYSA-N 279015 3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4-yl)methyl)amino)-1H-pyrazolo[4,3-b]pyridin-5-yl)-1-methylpyridin-2(1H)-one::US10034861, Example 45::US10512632, Example 45::US10806718, Example 45::US11026923, Example 45::US11491140, Example 45::US11634416, Example 45 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.00 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279015 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279015&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273343 378160604 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967273 CCOc1ncccc1-c1cc(NCc2c[nH]c(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H27N7O/c1-6-30-22-17(8-7-9-23-22)18-10-19(25-12-16-11-24-15(5)26-16)21-20(27-18)14(4)28-29(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,24,26)(H,25,27) OESORFJHOJQXKR-UHFFFAOYSA-N 279016 5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((2-methyl-1H-imidazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 46::US10512632, Example 46::US10766893, Example S46::US10806718, Example 46::US11026923, Example 46::US11491140, Example 46::US11634416, Example 46 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 5.00 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279016&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273345 378160605 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967276 CCOc1ncccc1-c1cc(NCc2cc(C)[nH]n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H27N7O/c1-6-30-22-17(8-7-9-23-22)18-11-19(24-12-16-10-14(4)26-27-16)21-20(25-18)15(5)28-29(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,24,25)(H,26,27) BKIZQOUWXXJIIE-UHFFFAOYSA-N 279017 5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((5-methyl-1H-pyrazol-3-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 47::US10512632, Example 47::US10766893, Example S54::US10806718, Example 47::US11026923, Example 47::US11491140, Example 47::US11634416, Example 47 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.60 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279017&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273346 378160606 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967279 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(CC)nc(C)c2n1 InChI=1S/C21H25N7O/c1-5-28-20-18(23-11-15-12-24-27(4)13-15)10-17(25-19(20)14(3)26-28)16-8-7-9-22-21(16)29-6-2/h7-10,12-13H,5-6,11H2,1-4H3,(H,23,25) ALQSQGPOANFHOP-UHFFFAOYSA-N 279018 5-(2-ethoxypyridin-3-yl)-1-ethyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 48::US10512632, Example 48::US10618913, Example S48::US10766893, Example S48::US10806718, Example 48::US11026923, Example 48::US11491140, Example 48::US11634416, Example 48 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 38.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279018&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273347 378160607 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967282 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1cccn(C)c1=O InChI=1S/C21H25N7O/c1-13(2)28-20-18(22-10-15-11-23-27(5)12-15)9-17(24-19(20)14(3)25-28)16-7-6-8-26(4)21(16)29/h6-9,11-13H,10H2,1-5H3,(H,22,24) MRQVRXHGMURIIP-UHFFFAOYSA-N 279019 3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4-yl)methyl)amino)-1H-pyrazolo[4,3-b]pyridin-5-yl)-1-methylpyridin-2(1H)-one::US10034861, Example 49::US10512632, Example 49::US10766893, Example S49::US10806718, Example 49::US11026923, Example 49::US11491140, Example 49::US11634416, Example 49 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 170 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279019 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279019&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273348 378160608 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967285 CCOc1ncccc1-c1cc(NCc2nc(C)co2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6O2/c1-6-29-22-16(8-7-9-23-22)17-10-18(24-11-19-25-14(4)12-30-19)21-20(26-17)15(5)27-28(21)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,24,26) LWOWQQZYEXAZTD-UHFFFAOYSA-N 279020 5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((4-methyloxazol-2-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine 2,2,2-trifluoroacetate::US10034861, Example 50::US10512632, Example 50::US10766893, Example S50::US10806718, Example 50::US11026923, Example 50::US11491140, Example 50::US11634416, Example 50 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 9.00 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279020 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279020&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273350 378160609 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967288 CCOc1ncccc1-c1cc(NCc2cn(C)c(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H29N7O/c1-7-31-23-18(9-8-10-24-23)19-11-20(25-12-17-13-29(6)16(5)26-17)22-21(27-19)15(4)28-30(22)14(2)3/h8-11,13-14H,7,12H2,1-6H3,(H,25,27) RIBLUNUCLUPFGL-UHFFFAOYSA-N 279021 N-((1,2-dimethyl-1H-imidazol-4-yl)methyl)-5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-1H-pyrazolo[4,3-b]pyridin-7-amine 2,2,2-trifluoroacetate::US10034861, Example 51::US10512632, Example 51::US10766893, Example S51::US10806718, Example 51::US11026923, Example 51::US11491140, Example 51::US11634416, Example 51 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 53.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279021 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279021&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273354 378160610 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967291 CCOc1ncccc1-c1cc(NCc2noc(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H25N7O2/c1-6-29-21-15(8-7-9-22-21)16-10-17(23-11-18-24-14(5)30-27-18)20-19(25-16)13(4)26-28(20)12(2)3/h7-10,12H,6,11H2,1-5H3,(H,23,25) GALBTAGDVOLYTK-UHFFFAOYSA-N 279022 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 52::US10512632, Example 52::US10766893, Example S52::US10806718, Example 52::US11026923, Example 52::US11491140, Example 52 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.90 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279022 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279022&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273351 378160611 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967294 CCOc1ncccc1-c1cc(NCc2ncon2)c2n(nc(C)c2n1)C(C)C InChI=1S/C20H23N7O2/c1-5-28-20-14(7-6-8-21-20)15-9-16(22-10-17-23-11-29-26-17)19-18(24-15)13(4)25-27(19)12(2)3/h6-9,11-12H,5,10H2,1-4H3,(H,22,24) HUAHNRHWFFYRAT-UHFFFAOYSA-N 279023 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1,2,4-oxadiazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 53::US10512632, Example 53::US10766893, Example S53::US10806718, Example 53::US11026923, Example 53::US11491140, Example 53::US11634416, Example 53 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 9.30 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279023&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273357 378160612 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967297 CCOc1ncccc1-c1cc(NCc2cc(C)n(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H29N7O/c1-7-31-23-18(9-8-10-24-23)19-12-20(25-13-17-11-15(4)29(6)28-17)22-21(26-19)16(5)27-30(22)14(2)3/h8-12,14H,7,13H2,1-6H3,(H,25,26) LOSBPLVFUGTAOA-UHFFFAOYSA-N 279024 N-[(1,5-dimethylpyrazol-3-yl)methyl]-5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 54::US10512632, Example 54::US10806718, Example 54::US11026923, Example 54::US11491140, Example 54::US11634416, Example 54 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.390 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279024 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279024&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273352 378160613 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967300 CCOc1ncccc1-c1cc(NCc2n[nH]c(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-6-30-21-15(8-7-9-22-21)16-10-17(23-11-18-24-14(5)26-27-18)20-19(25-16)13(4)28-29(20)12(2)3/h7-10,12H,6,11H2,1-5H3,(H,23,25)(H,24,26,27) QVFBWQCMGPADBC-UHFFFAOYSA-N 279025 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methyl-1H-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 55::US10512632, Example 55::US10766893, Example S55::US10806718, Example 55::US11026923, Example 55::US11491140, Example 55::US11634416, Example 55 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 3.40 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279025&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273353 378160614 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967303 CCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(ncc2n1)C(C)C InChI=1S/C20H24N8O/c1-5-29-20-14(7-6-8-21-20)15-9-16(22-11-18-23-12-27(4)26-18)19-17(25-15)10-24-28(19)13(2)3/h6-10,12-13H,5,11H2,1-4H3,(H,22,25) LBAWYUCYPDZBSF-UHFFFAOYSA-N 279026 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 56::US10512632, Example 56::US10766893, Example S56::US10806718, Example 56::US11026923, Example 56::US11491140, Example 56::US11634416, Example 56 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 16.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279026&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273358 378160615 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967306 CCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(ncc2n1)C(C)C InChI=1S/C20H23N7O/c1-4-28-20-15(6-5-8-21-20)16-10-17(22-11-14-7-9-23-26-14)19-18(25-16)12-24-27(19)13(2)3/h5-10,12-13H,4,11H2,1-3H3,(H,22,25)(H,23,26) RZEYZCLEVMBHDS-UHFFFAOYSA-N 279027 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 57::US10512632, Example 57::US10766893, Example S57::US10806718, Example 57::US11026923, Example 57::US11491140, Example 57::US11634416, Example 57 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 98.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279027&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273355 378160616 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967309 CCOc1ncccc1-c1cc(NCc2cn(C)cn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H27N7O/c1-6-30-22-17(8-7-9-23-22)18-10-19(24-11-16-12-28(5)13-25-16)21-20(26-18)15(4)27-29(21)14(2)3/h7-10,12-14H,6,11H2,1-5H3,(H,24,26) LRTCNZDFQQIFPH-UHFFFAOYSA-N 279028 5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((1-methyl-1H-imidazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine 2,2,2-trifluoroacetate::US10034861, Example 58::US10512632, Example 58::US10766893, Example S58::US10806718, Example 58::US11026923, Example 58::US11491140, Example 58::US11634416, Example 58 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.10 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279028&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273360 378160617 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967312 CCOc1ncccc1-c1cc(NCc2nnco2)c2n(nc(C)c2n1)C(C)C InChI=1S/C20H23N7O2/c1-5-28-20-14(7-6-8-21-20)15-9-16(22-10-17-25-23-11-29-17)19-18(24-15)13(4)26-27(19)12(2)3/h6-9,11-12H,5,10H2,1-4H3,(H,22,24) AHFKEZBAZQXEDY-UHFFFAOYSA-N 279029 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1,3,4-oxadiazol-2-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 59::US10512632, Example 59::US10766893, Example S59::US10806718, Example 59::US11026923, Example 59::US11491140, Example 59::US11634416, Example 59 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 55.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279029&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273356 378160618 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967315 CCOc1ncccc1-c1cc(NCc2ccn(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H27N7O/c1-6-30-22-17(8-7-10-23-22)18-12-19(24-13-16-9-11-28(5)27-16)21-20(25-18)15(4)26-29(21)14(2)3/h7-12,14H,6,13H2,1-5H3,(H,24,25) FXMRNOZDEMMBMY-UHFFFAOYSA-N 279030 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(1-methylpyrazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 60::US10512632, Example 60::US10766893, Example S60::US10806718, Example 60::US11491140, Example 60::US11634416, Example 60 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 6.50 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279030&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273369 378160619 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967318 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1cn(C)nc1C InChI=1S/C20H26N8/c1-12(2)28-20-18(21-8-15-9-22-26(5)10-15)7-17(23-19(20)14(4)25-28)16-11-27(6)24-13(16)3/h7,9-12H,8H2,1-6H3,(H,21,23) SZOKENQFAYLAJE-UHFFFAOYSA-N 279031 5-(1,3-dimethylpyrazol-4-yl)-1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 61::US10512632, Example 61::US10618913, Example S61::US10766893, Example S61::US10806718, Example 61::US11491140, Example 61::US11634416, Example 61 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 550 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279031&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273370 378160620 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967321 COc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H25N7O/c1-13(2)28-20-18(23-10-15-11-24-27(4)12-15)9-17(25-19(20)14(3)26-28)16-7-6-8-22-21(16)29-5/h6-9,11-13H,10H2,1-5H3,(H,23,25) NDQZTZXQHDYXCS-UHFFFAOYSA-N 279032 1-isopropyl-5-(2-methoxy-3-pyridyl)-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 62::US10512632, Example 62::US10766893, Example S62::US10806718, Example 62::US11491140, Example 62::US11634416, Example 62 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 16.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279032&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273362 378160621 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967324 COc1ccccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6O/c1-14(2)28-22-19(23-11-16-12-24-27(4)13-16)10-18(25-21(22)15(3)26-28)17-8-6-7-9-20(17)29-5/h6-10,12-14H,11H2,1-5H3,(H,23,25) KTDTYSKLFCIVHF-UHFFFAOYSA-N 279033 1-isopropyl-5-(2-methoxyphenyl)-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 63::US10512632, Example 63::US10766893, Example S63::US10806718, Example 63::US11491140, Example 63::US11634416, Example 63 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 64.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279033&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273359 378160622 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967327 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1ccccc1 InChI=1S/C21H24N6/c1-14(2)27-21-19(22-11-16-12-23-26(4)13-16)10-18(17-8-6-5-7-9-17)24-20(21)15(3)25-27/h5-10,12-14H,11H2,1-4H3,(H,22,24) JFQFIBIPASGZMG-UHFFFAOYSA-N 279034 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-phenyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 64::US10512632, Example 64::US10766893, Example S64::US10806718, Example 64::US11491140, Example 64::US11634416, Example 64 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 52.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279034&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273365 378160623 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967330 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1ccsc1C InChI=1S/C20H24N6S/c1-12(2)26-20-18(21-9-15-10-22-25(5)11-15)8-17(16-6-7-27-14(16)4)23-19(20)13(3)24-26/h6-8,10-12H,9H2,1-5H3,(H,21,23) OOGMCENLMFETDO-UHFFFAOYSA-N 279035 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-(2-methyl-3-thienyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 65::US10512632, Example 65::US10766893, Example S65::US10806718, Example 65::US11491140, Example 65::US11634416, Example 65 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 7.90 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279035&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273363 378160624 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967333 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1cnn(C)c1C InChI=1S/C20H26N8/c1-12(2)28-20-18(21-8-15-9-22-26(5)11-15)7-17(24-19(20)13(3)25-28)16-10-23-27(6)14(16)4/h7,9-12H,8H2,1-6H3,(H,21,24) IOBLPVSVJNVETM-UHFFFAOYSA-N 279036 5-(1,5-dimethylpyrazol-4-yl)-1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 66::US10512632, Example 66::US10766893, Example S66::US10806718, Example 66::US11491140, Example 66::US11634416, Example 66 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 210 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279036&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273361 378160625 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967336 CCOc1ncccc1-c1cc(NCc2ccn(C)n2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C23H29N7O/c1-6-15(3)30-22-20(25-14-17-10-12-29(5)28-17)13-19(26-21(22)16(4)27-30)18-9-8-11-24-23(18)31-7-2/h8-13,15H,6-7,14H2,1-5H3,(H,25,26) GUZUXYPWYDLGJF-UHFFFAOYSA-N 279037 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]-N-[(1-methylpyrazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 67::US10512632, Example 67::US10618913, Example S67::US10766893, Example S67::US10806718, Example 67::US11634416, Example 67 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 9.60 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279037 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279037&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273371 378160626 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967339 CCCOc1ncccc1-c1cc(NCc2nnn(C)n2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C22H29N9O/c1-6-11-32-22-16(9-8-10-23-22)17-12-18(24-13-19-26-29-30(5)28-19)21-20(25-17)15(4)27-31(21)14(3)7-2/h8-10,12,14H,6-7,11,13H2,1-5H3,(H,24,25) DGDYHVXCROBNNK-UHFFFAOYSA-N 279038 3-methyl-1-[1-methylpropyl]-N-[(2-methyltetrazol-5-yl)methyl]-5-(2-propoxy-3-pyridyl)pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 68::US10512632, Example 68::US10766893, Example S68::US10806718, Example 68::US11634416, Example 68 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.790 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279038 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279038&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273364 378160627 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967342 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(ncc2n1)C(C)CC InChI=1S/C22H27N7O/c1-5-15(3)29-21-19(24-11-16-12-25-28(4)14-16)10-18(27-20(21)13-26-29)17-8-7-9-23-22(17)30-6-2/h7-10,12-15H,5-6,11H2,1-4H3,(H,24,27) PNGBBNJWUZFNIY-UHFFFAOYSA-N 279039 5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine, enantiomer 1::US10034861, Example 69::US10034861, Example 70::US10512632, Example 70::US10618913, Example S69::US10766893, Example S70::US10806718, Example 70::US11634416, Example 70 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 14.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279039&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273366 378160628 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967345 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(ncc2n1)C(C)CC InChI=1S/C22H27N7O/c1-5-15(3)29-21-19(24-11-16-12-25-28(4)14-16)10-18(27-20(21)13-26-29)17-8-7-9-23-22(17)30-6-2/h7-10,12-15H,5-6,11H2,1-4H3,(H,24,27) PNGBBNJWUZFNIY-UHFFFAOYSA-N 279039 5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine, enantiomer 1::US10034861, Example 69::US10034861, Example 70::US10512632, Example 70::US10618913, Example S69::US10766893, Example S70::US10806718, Example 70::US11634416, Example 70 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 140 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279039&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273366 378160628 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967348 CCOc1ncccc1-c1cc(NCc2scnc2C)c2n(ncc2n1)C(C)C InChI=1S/C21H24N6OS/c1-5-28-21-15(7-6-8-22-21)16-9-17(23-11-19-14(4)24-12-29-19)20-18(26-16)10-25-27(20)13(2)3/h6-10,12-13H,5,11H2,1-4H3,(H,23,26) CKGZFAMXPLRINR-UHFFFAOYSA-N 424981 US10512632, Example 71::US10766893, Example S71::US10806718, Example 71::US11026923, Example 71::US11491140, Example 71::US11634416, Example 71 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 170 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=424981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=424981&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138536011 434150492 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967351 CCOc1ncccc1-c1cc(OCc2cnc(C)o2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H25N5O3/c1-6-28-22-17(8-7-9-23-22)18-10-19(29-12-16-11-24-15(5)30-16)21-20(25-18)14(4)26-27(21)13(2)3/h7-11,13H,6,12H2,1-5H3 PFDYAXRVKURLCH-UHFFFAOYSA-N 279042 5-[[5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-yl]oxymethyl]-2-methyl-oxazole::US10034861, Example 72::US10512632, Example 72::US10766893, Example S72::US10806718, Example 72::US11491140, Example 72::US11634416, Example 72 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 14.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279042&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273372 378160630 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967354 CCOc1ncccc1-c1cc(NCc2ccncn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H25N7O/c1-5-30-22-17(7-6-9-24-22)18-11-19(25-12-16-8-10-23-13-26-16)21-20(27-18)15(4)28-29(21)14(2)3/h6-11,13-14H,5,12H2,1-4H3,(H,25,27) UIVWJGFOIVSSOG-UHFFFAOYSA-N 279043 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(pyrimidin-4-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 73::US10512632, Example 73::US10766893, Example S73::US10806718, Example 73::US11491140, Example 73::US11634416, Example 73 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 81.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279043&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273379 378160631 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967357 CCOc1ncccc1-c1cc(NCc2ncccn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H25N7O/c1-5-30-22-16(8-6-9-25-22)17-12-18(26-13-19-23-10-7-11-24-19)21-20(27-17)15(4)28-29(21)14(2)3/h6-12,14H,5,13H2,1-4H3,(H,26,27) DFFZMDINLLNNPV-UHFFFAOYSA-N 279044 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(pyrimidin-2-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 74::US10512632, Example 74::US10766893, Example S74::US10806718, Example 74::US11491140, Example 74::US11634416, Example 74 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.10 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279044&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273368 378160632 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967360 CCOc1ncccc1-c1cc(NCc2nccc(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O/c1-6-31-23-17(8-7-10-25-23)18-12-19(26-13-20-24-11-9-15(4)27-20)22-21(28-18)16(5)29-30(22)14(2)3/h7-12,14H,6,13H2,1-5H3,(H,26,28) ZCARSOPJYGJCRQ-UHFFFAOYSA-N 279045 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(4-methylpyrimidin-2-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 75::US10512632, Example 75::US10806718, Example 75::US11026923, Example 75::US11491140, Example 75::US11634416, Example 75 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 9.90 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279045&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273374 378160633 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967363 CCOc1ncccc1-c1cc(NCc2cnccn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H25N7O/c1-5-30-22-17(7-6-8-25-22)18-11-19(26-13-16-12-23-9-10-24-16)21-20(27-18)15(4)28-29(21)14(2)3/h6-12,14H,5,13H2,1-4H3,(H,26,27) DTEHKURDWHCADV-UHFFFAOYSA-N 279046 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(pyrazin-2-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 76::US10512632, Example 76::US10766893, Example S76::US10806718, Example 76::US11026923, Example 76::US11491140, Example 76::US11634416, Example 76 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 23.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279046&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273373 378160634 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967366 CCOc1ncccc1-c1cc(NCc2cccnc2C(F)(F)F)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H25F3N6O/c1-5-34-23-17(9-7-11-29-23)18-12-19(21-20(31-18)15(4)32-33(21)14(2)3)30-13-16-8-6-10-28-22(16)24(25,26)27/h6-12,14H,5,13H2,1-4H3,(H,30,31) TZBBGNNWRKPAEH-UHFFFAOYSA-N 279047 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[2-(trifluoromethyl)-3-pyridyl]methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 77::US10512632, Example 77::US10766893, Example S77::US10806718, Example 77::US11026923, Example 77::US11491140, Example 77::US11634416, Example 77 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 21.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279047&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273376 378160635 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 967369 CCOc1ncccc1-c1cc(NCc2ccn(C)c(=O)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(8-7-10-25-24)19-13-20(26-14-17-9-11-29(5)21(31)12-17)23-22(27-19)16(4)28-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,26,27) IBAWDCALOOJODQ-UHFFFAOYSA-N 279048 4-[[[5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-yl]amino]methyl]-1-methyl-pyridin-2-one::US10034861, Example 78::US10512632, Example 78::US10766893, Example S78::US10806718, Example 78::US11026923, Example 78::US11491140, Example 78::US11634416, Example 78 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 27.0 US Patent 10.7270/Q27P92FR aid1804915 US10806718 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279048&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273377 378160636 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983472 CCCc1ncc2n1cc(C)n(Cc1ccc(OC)cc1)c2=O InChI=1S/C18H21N3O2/c1-4-5-17-19-10-16-18(22)20(13(2)11-21(16)17)12-14-6-8-15(23-3)9-7-14/h6-11H,4-5,12H2,1-3H3 YMHRUXWRFFVZTC-UHFFFAOYSA-N 474176 7-(4-methoxybenzyl)-6-methyl-3- propylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 56::US10912773, Example 56::US11472810, Example 56 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 65.0 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474176 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474176&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652426 442074374 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983475 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C2CCOCC2)cn1 InChI=1S/C19H22N4O3/c1-13-11-23-16(10-21-18(23)15-5-7-26-8-6-15)19(24)22(13)12-14-3-4-17(25-2)20-9-14/h3-4,9-11,15H,5-8,12H2,1-2H3 OVPVMIDVNMKKNU-UHFFFAOYSA-N 474177 7-((6-methoxypyridin-3- yl)methyl)-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 57::US10912773, Example 57::US11472810, Example 57 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 45.0 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474177 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474177&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652538 442074375 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983479 CCn1c(C)cn2c(ncc2c1=O)C1CCOCC1 InChI=1S/C14H19N3O2/c1-3-16-10(2)9-17-12(14(16)18)8-15-13(17)11-4-6-19-7-5-11/h8-9,11H,3-7H2,1-2H3 WESIRYTURBTMCP-UHFFFAOYSA-N 474179 7-ethyl-6-methyl-3-(tetrahydro- 2H-pyran-4-yl)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 59::US10912773, Example 59::US11472810, Example 59 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2333 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474179 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474179&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652457 442074377 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983482 CCCn1c(C)cn2c(ncc2c1=O)C1CCOCC1 InChI=1S/C15H21N3O2/c1-3-6-17-11(2)10-18-13(15(17)19)9-16-14(18)12-4-7-20-8-5-12/h9-10,12H,3-8H2,1-2H3 ARICWMJJQKCTDR-UHFFFAOYSA-N 474180 6-methyl-7-propyl-3-(tetrahydro- 2H-pyran-4-yl)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 60::US10912773, Example 60::US11472810, Example 60 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 810 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474180 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474180&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652455 442074378 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983485 CC(C)CCn1c(C)cn2c(ncc2c1=O)C1CCOCC1 InChI=1S/C17H25N3O2/c1-12(2)4-7-19-13(3)11-20-15(17(19)21)10-18-16(20)14-5-8-22-9-6-14/h10-12,14H,4-9H2,1-3H3 OEYDINZBWMRAIK-UHFFFAOYSA-N 474181 7-isopentyl-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 62::US10912773, Example 62::US11472810, Example 62 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1078 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474181&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652305 442074379 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983488 Cc1cn2c(ncc2c(=O)n1CC1CCCC1)C1CCOCC1 InChI=1S/C18H25N3O2/c1-13-11-21-16(10-19-17(21)15-6-8-23-9-7-15)18(22)20(13)12-14-4-2-3-5-14/h10-11,14-15H,2-9,12H2,1H3 IVIOKHSMYSCNPJ-UHFFFAOYSA-N 474182 7-(cyclopentylmethyl)-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 63::US10912773, Example 63::US11472810, Example 63 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 183 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474182 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474182&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652331 442074380 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983491 Cc1cn2c(ncc2c(=O)n1Cc1ccccc1C#N)C1CCOCC1 InChI=1S/C20H20N4O2/c1-14-12-24-18(11-22-19(24)15-6-8-26-9-7-15)20(25)23(14)13-17-5-3-2-4-16(17)10-21/h2-5,11-12,15H,6-9,13H2,1H3 ISOFGIBMBLOJRH-UHFFFAOYSA-N 474183 2-((6-methyl-8-oxo-3-(tetrahydro- 2H-pyran-4-yl)imidazo[1,5- a]pyrazin-7(8H)- yl)methyl)benzonitrile::US10858362, Example 64::US10912773, Example 64::US11472810, Example 64 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 624 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474183&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652237 442074381 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983494 Cc1cn2c(ncc2c(=O)n1CC1CCCCCC1)C1CCOCC1 InChI=1S/C20H29N3O2/c1-15-13-23-18(12-21-19(23)17-8-10-25-11-9-17)20(24)22(15)14-16-6-4-2-3-5-7-16/h12-13,16-17H,2-11,14H2,1H3 FIIDAEWKLGRESO-UHFFFAOYSA-N 474184 7-(cycloheptylmethyl)-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 65::US10912773, Example 65::US11472810, Example 65 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 10.00 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474184 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474184&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652324 442074382 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983497 CC1CCC(Cn2c(C)cn3c(ncc3c2=O)C2CCOCC2)CC1 InChI=1S/C20H29N3O2/c1-14-3-5-16(6-4-14)13-22-15(2)12-23-18(20(22)24)11-21-19(23)17-7-9-25-10-8-17/h11-12,14,16-17H,3-10,13H2,1-2H3 OUZGHMLKYZAFHY-UHFFFAOYSA-N 474185 6-methyl-7-(((trans)-4- methylcyclohexyl)methyl)-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 66--cis::US10858362, Example 66--trans Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 35.0 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474185 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474185&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652228 442074383 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983500 CC1CCC(Cn2c(C)cn3c(ncc3c2=O)C2CCOCC2)CC1 InChI=1S/C20H29N3O2/c1-14-3-5-16(6-4-14)13-22-15(2)12-23-18(20(22)24)11-21-19(23)17-7-9-25-10-8-17/h11-12,14,16-17H,3-10,13H2,1-2H3 OUZGHMLKYZAFHY-UHFFFAOYSA-N 474185 6-methyl-7-(((trans)-4- methylcyclohexyl)methyl)-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 66--cis::US10858362, Example 66--trans Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 7.00 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474185 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474185&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652228 442074383 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983503 CO[C@@H]1CC[C@H](Cn2c(C)cn3c(ncc3c2=O)C2CCOCC2)CC1 InChI=1S/C20H29N3O3/c1-14-12-23-18(11-21-19(23)16-7-9-26-10-8-16)20(24)22(14)13-15-3-5-17(25-2)6-4-15/h11-12,15-17H,3-10,13H2,1-2H3/t15-,17+ RPFGNHZGIBGJKF-WOVMCDHWSA-N 474187 7-(((cis)-4- methoxycyclohexyl)methyl)-6- methyl-3-(tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 67::US11472810, Example 67 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 234 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474187 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474187&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652247 442074384 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983506 CO[C@H]1CC[C@H](Cn2c(C)cn3c(ncc3c2=O)C2CCOCC2)CC1 InChI=1S/C20H29N3O3/c1-14-12-23-18(11-21-19(23)16-7-9-26-10-8-16)20(24)22(14)13-15-3-5-17(25-2)6-4-15/h11-12,15-17H,3-10,13H2,1-2H3/t15-,17- RPFGNHZGIBGJKF-JCNLHEQBSA-N 474188 7-(((trans)-4- methoxycyclohexyl)methyl)-6- methyl-3-(tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 68::US11472810, Example 68 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 323 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474188 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474188&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652247 442074385 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983509 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C2CCOCC2C)cc1 InChI=1S/C21H25N3O3/c1-14-13-27-9-8-18(14)20-22-10-19-21(25)23(15(2)11-24(19)20)12-16-4-6-17(26-3)7-5-16/h4-7,10-11,14,18H,8-9,12-13H2,1-3H3 YTOUKKHZMQVQLZ-UHFFFAOYSA-N 474189 7-(4-methoxybenzyl)-6-methyl-3- (3-methyltetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 69::US10912773, Example 69::US11472810, Example 69 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 13.0 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474189&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652323 442074386 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983512 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C2(C)CC3CCC2O3)cc1 InChI=1S/C22H25N3O3/c1-14-12-25-18(11-23-21(25)22(2)10-17-8-9-19(22)28-17)20(26)24(14)13-15-4-6-16(27-3)7-5-15/h4-7,11-12,17,19H,8-10,13H2,1-3H3 NRIDLTZEDZLZBY-UHFFFAOYSA-N 474190 7-(4-methoxybenzyl)-6-methyl-3- ((1R,2R,4S)-2-methyl-7- oxabicyclo[2.2.1]heptan-2- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 70::US10912773, Example 70::US11472810, Example 70 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 29.0 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474190 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474190&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122663821 442074387 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983515 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)[C@@H](C)c2ccccc2)cc1 InChI=1S/C23H23N3O2/c1-16-14-26-21(13-24-22(26)17(2)19-7-5-4-6-8-19)23(27)25(16)15-18-9-11-20(28-3)12-10-18/h4-14,17H,15H2,1-3H3/t17-/m0/s1 SWHFTCTZWOUUQD-KRWDZBQOSA-N 474191 (S)-7-(4-methoxybenzyl)-6- methyl-3-(1- phenylethyl)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 71::US10912773, Example 71::US11472810, Example 71 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 211 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474191 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474191&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652214 442074388 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983518 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)[C@H](C)c2ccccc2)cc1 InChI=1S/C23H23N3O2/c1-16-14-26-21(13-24-22(26)17(2)19-7-5-4-6-8-19)23(27)25(16)15-18-9-11-20(28-3)12-10-18/h4-14,17H,15H2,1-3H3/t17-/m1/s1 SWHFTCTZWOUUQD-QGZVFWFLSA-N 474192 (R)-7-(4-methoxybenzyl)-6- methyl-3-(1- phenylethyl)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 72::US10912773, Example 72::US11472810, Example 72 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 90.0 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474192&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652402 442074389 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983521 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C2(C)CCN(C)CC2)cc1 InChI=1S/C22H28N4O2/c1-16-14-26-19(13-23-21(26)22(2)9-11-24(3)12-10-22)20(27)25(16)15-17-5-7-18(28-4)8-6-17/h5-8,13-14H,9-12,15H2,1-4H3 UOMHYPRQAMXYDQ-UHFFFAOYSA-N 474193 3-(1,4-dimethylpiperidin-4-yl)-7- (4-methoxybenzyl)-6- methylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 73::US10912773, Example 73::US11472810, Example 73 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1923 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474193 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474193&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652233 442074390 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983524 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C2CCc3ccc(Cl)cc23)cc1 InChI=1S/C24H22ClN3O2/c1-15-13-28-22(24(29)27(15)14-16-3-8-19(30-2)9-4-16)12-26-23(28)20-10-6-17-5-7-18(25)11-21(17)20/h3-5,7-9,11-13,20H,6,10,14H2,1-2H3 COANVSPOSPBLGF-UHFFFAOYSA-N 474194 3-(6-chloro-2,3-dihydro-1H- inden-1-yl)-7-(4-methoxybenzyl)- 6-methylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 74::US10912773, Example 74::US11472810, Example 74 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 5.00 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474194 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474194&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652306 442074391 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983527 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C2(C)CNC(=O)C2)cc1 InChI=1S/C20H22N4O3/c1-13-10-24-16(9-21-19(24)20(2)8-17(25)22-12-20)18(26)23(13)11-14-4-6-15(27-3)7-5-14/h4-7,9-10H,8,11-12H2,1-3H3,(H,22,25) XKGOGXSNJQICIE-UHFFFAOYSA-N 474195 7-(4-methoxybenzyl)-6-methyl-3- (3-methyl-5-oxopyrrolidin-3- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 75::US10912773, Example 75::US11472810, Example 75 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 236 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474195&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652486 442074392 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983530 COCC(C)(C)c1ncc2n1cc(C)n(Cc1ccc(OC)cc1)c2=O InChI=1S/C20H25N3O3/c1-14-11-23-17(10-21-19(23)20(2,3)13-25-4)18(24)22(14)12-15-6-8-16(26-5)9-7-15/h6-11H,12-13H2,1-5H3 ANGLWHGRWFOZSQ-UHFFFAOYSA-N 474196 3-(1-methoxy-2-methylpropan-2- yl)-7-(4-methoxybenzyl)-6- methylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 76::US10912773, Example 76::US11472810, Example 76 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 122 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474196 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474196&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652293 442074393 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983533 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C(C)C)cc1 InChI=1S/C18H21N3O2/c1-12(2)17-19-9-16-18(22)20(13(3)10-21(16)17)11-14-5-7-15(23-4)8-6-14/h5-10,12H,11H2,1-4H3 RVHZRSIRMVWVKL-UHFFFAOYSA-N 474197 3-isopropyl-7-(4-methoxybenzyl)- 6-methylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 77::US10912773, Example 77::US11472810, Example 77 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 13.0 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474197 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474197&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652354 442074394 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983536 Cc1nc(Cn2c(C)cn3c(ncc3c2=O)C2CCOCC2)cs1 InChI=1S/C17H20N4O2S/c1-11-8-21-15(7-18-16(21)13-3-5-23-6-4-13)17(22)20(11)9-14-10-24-12(2)19-14/h7-8,10,13H,3-6,9H2,1-2H3 SFJUWCCYAPWXBB-UHFFFAOYSA-N 474198 6-methyl-7-((2-methylthiazol-4- yl)methyl)-3-(tetrahydro-2H- pyran-4-yl)imidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 78::US10912773, Example 78::US11472810, Example 78 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1691 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474198 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474198&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652259 442074395 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983539 Cc1cn2c(ncc2c(=O)n1Cc1ccsc1)C1CCOCC1 InChI=1S/C17H19N3O2S/c1-12-9-20-15(8-18-16(20)14-2-5-22-6-3-14)17(21)19(12)10-13-4-7-23-11-13/h4,7-9,11,14H,2-3,5-6,10H2,1H3 VRSLRMWKAICODM-UHFFFAOYSA-N 474199 6-methyl-3-(tetrahydro-2H-pyran- 4-yl)-7-(thiophen-3- ylmethyl)imidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 79::US10905688, Example 79 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 228 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474199 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474199&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652355 442074396 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983547 Cc1cc(Cn2c(C)cn3c(ncc3c2=O)C2CCOCC2)on1 InChI=1S/C17H20N4O3/c1-11-7-14(24-19-11)10-20-12(2)9-21-15(17(20)22)8-18-16(21)13-3-5-23-6-4-13/h7-9,13H,3-6,10H2,1-2H3 ZKIKXHAKXUODEV-UHFFFAOYSA-N 474203 6-methyl-7-((3-methylisoxazol-5- yl)methyl)-3-(tetrahydro-2H- pyran-4-yl)imidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 83::US10912773, Example 83::US11472810, Example 83 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4444 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474203 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474203&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652332 442074400 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983550 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C2CC(C)OC(C)C2)cc1 InChI=1S/C22H27N3O3/c1-14-12-25-20(11-23-21(25)18-9-15(2)28-16(3)10-18)22(26)24(14)13-17-5-7-19(27-4)8-6-17/h5-8,11-12,15-16,18H,9-10,13H2,1-4H3 IJXXNTVMDPJVBW-UHFFFAOYSA-N 474204 3-(2,6-dimethyltetrahydro-2H- pyran-4-yl)-7-(4-methoxybenzyl)- 6-methylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 84::US10912773, Example 84::US11472810, Example 84 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 627 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474204 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474204&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652545 442074401 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983553 CCCc1ncc2n1cc(C)n(CC1CCCCC1)c2=O InChI=1S/C17H25N3O/c1-3-7-16-18-10-15-17(21)19(13(2)11-20(15)16)12-14-8-5-4-6-9-14/h10-11,14H,3-9,12H2,1-2H3 ZVDAZHCIEJDXMC-UHFFFAOYSA-N 474205 7-(cyclohexylmethyl)-6-methyl-3- propylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 85::US10912773, Example 85::US11472810, Example 85 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 120 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474205 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474205&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652381 442074402 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983556 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C(C)(C)O)cc1 InChI=1S/C18H21N3O3/c1-12-10-21-15(9-19-17(21)18(2,3)23)16(22)20(12)11-13-5-7-14(24-4)8-6-13/h5-10,23H,11H2,1-4H3 RVJAZKLTOAMCHB-UHFFFAOYSA-N 474206 3-(2-hydroxypropan-2-yl)-7-(4- methoxybenzyl)-6- methylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 86::US10912773, Example 86::US11472810, Example 86 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 193 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474206 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474206&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652382 442074403 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983559 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C(C)(C)F)cc1 InChI=1S/C18H20FN3O2/c1-12-10-22-15(9-20-17(22)18(2,3)19)16(23)21(12)11-13-5-7-14(24-4)8-6-13/h5-10H,11H2,1-4H3 DKRDXFRQADAIHU-UHFFFAOYSA-N 474207 3-(2-fluoropropan-2-yl)-7-(4- methoxybenzyl)-6- methylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 87::US10912773, Example 87::US11472810, Example 87 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 108 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474207 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474207&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652496 442074404 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983562 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C2CCNC(=O)CC2)cc1 InChI=1S/C21H24N4O3/c1-14-12-25-18(11-23-20(25)16-5-8-19(26)22-10-9-16)21(27)24(14)13-15-3-6-17(28-2)7-4-15/h3-4,6-7,11-12,16H,5,8-10,13H2,1-2H3,(H,22,26) ZMTDJXQCSYULBW-UHFFFAOYSA-N 474208 7-(4-methoxybenzyl)-6-methyl-3- (7-oxoazepan-4-yl)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 88::US10912773, Example 88::US11472810, Example 88 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 484 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474208&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652312 442074405 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983567 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C(C)c2nc(C)cs2)cc1 InChI=1S/C21H22N4O2S/c1-13-12-28-20(23-13)15(3)19-22-9-18-21(26)24(14(2)10-25(18)19)11-16-5-7-17(27-4)8-6-16/h5-10,12,15H,11H2,1-4H3 XRYJHUBBBIIQDO-UHFFFAOYSA-N 474210 7-(4-methoxybenzyl)-6-methyl-3- (1-(4-methylthiazol-2- yl)ethyl)imidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 90::US10912773, Example 90::US11472810, Example 90 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 34.0 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474210&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652338 442074407 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983570 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C2(C)CCN(C2)S(N)(=O)=O)cc1 InChI=1S/C20H25N5O4S/c1-14-11-25-17(18(26)24(14)12-15-4-6-16(29-3)7-5-15)10-22-19(25)20(2)8-9-23(13-20)30(21,27)28/h4-7,10-11H,8-9,12-13H2,1-3H3,(H2,21,27,28) RZZDUEKLZBHEJJ-UHFFFAOYSA-N 474211 3-(7-(4-methoxybenzyl)-6-methyl- 8-oxo-7,8-dihydroimidazo[1,5- a]pyrazin-3-yl)-3- methylpyrrolidine-1-sulfonamide::US10858362, Example 91::US10912773, Example 91::US11472810, Example 91 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 181 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474211 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474211&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652235 442074408 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983573 COc1ccc(Cn2c(CC3CCCC3)cn3c(ncc3c2=O)C2CCOCC2)cc1 InChI=1S/C25H31N3O3/c1-30-22-8-6-19(7-9-22)16-27-21(14-18-4-2-3-5-18)17-28-23(25(27)29)15-26-24(28)20-10-12-31-13-11-20/h6-9,15,17-18,20H,2-5,10-14,16H2,1H3 TUNXEGCQHJFZRL-UHFFFAOYSA-N 474212 6-(cyclopentylmethyl)-7-(4- methoxybenzyl)-3-(tetrahydro- 2H-pyran-4-yl)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 92::US10912773, Example 92::US11472810, Example 92 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 71.0 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474212 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474212&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652475 442074409 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983576 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)N2CCOCC2)cc1 InChI=1S/C19H22N4O3/c1-14-12-23-17(11-20-19(23)21-7-9-26-10-8-21)18(24)22(14)13-15-3-5-16(25-2)6-4-15/h3-6,11-12H,7-10,13H2,1-2H3 DRHDVSISCJNWFF-UHFFFAOYSA-N 474213 3-(morpholino)-7-(4- methoxybenzyl)-6- methylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 93::US10912773, Example 93::US11472810, Example 93 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 96.0 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474213&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652234 442074410 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983579 COc1ccc(Cn2c(C)cn3c(NC4CCOC4)ncc3c2=O)cc1 InChI=1S/C19H22N4O3/c1-13-10-23-17(9-20-19(23)21-15-7-8-26-12-15)18(24)22(13)11-14-3-5-16(25-2)6-4-14/h3-6,9-10,15H,7-8,11-12H2,1-2H3,(H,20,21) MVGJRDDRTHNROA-UHFFFAOYSA-N 474214 7-(4-methoxybenzyl)-6-methyl-3- ((tetrahydrofuran-3- yl)amino)imidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 94::US10912773, Example 94::US11472810, Example 94 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2516 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474214 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474214&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652491 442074411 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983582 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)N2CCOC[C@H]2C)cc1 InChI=1S/C20H24N4O3/c1-14-11-24-18(10-21-20(24)22-8-9-27-13-15(22)2)19(25)23(14)12-16-4-6-17(26-3)7-5-16/h4-7,10-11,15H,8-9,12-13H2,1-3H3/t15-/m1/s1 VQUWFLFKDYALSX-OAHLLOKOSA-N 474215 (R)-7-(4-methoxybenzyl)-6- methyl-3-(3- methylmorpholino)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 95::US10912773, Example 95::US11472810, Example 95 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 258 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474215 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474215&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652374 442074412 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983585 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)N2CCOC[C@@H]2C)cc1 InChI=1S/C20H24N4O3/c1-14-11-24-18(10-21-20(24)22-8-9-27-13-15(22)2)19(25)23(14)12-16-4-6-17(26-3)7-5-16/h4-7,10-11,15H,8-9,12-13H2,1-3H3/t15-/m0/s1 VQUWFLFKDYALSX-HNNXBMFYSA-N 474216 (S)-7-(4-methoxybenzyl)-6- methyl-3-(3- methylmorpholino)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 96::US10912773, Example 96::US11472810, Example 96 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 48.0 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474216&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652225 442074413 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983588 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)N2CCCOCC2)cc1 InChI=1S/C20H24N4O3/c1-15-13-24-18(12-21-20(24)22-8-3-10-27-11-9-22)19(25)23(15)14-16-4-6-17(26-2)7-5-16/h4-7,12-13H,3,8-11,14H2,1-2H3 VCAGHSXTTDHBAV-UHFFFAOYSA-N 474217 7-(4-methoxybenzyl)-6-methyl-3- (1,4-oxazepan-4-yl)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 97::US10905688, Example 97::US11472810, Example 97 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 202 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474217 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474217&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652220 442074414 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983591 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)N2CCOC(C)(C)C2)cc1 InChI=1S/C21H26N4O3/c1-15-12-25-18(11-22-20(25)23-9-10-28-21(2,3)14-23)19(26)24(15)13-16-5-7-17(27-4)8-6-16/h5-8,11-12H,9-10,13-14H2,1-4H3 HVRCNXOHZPZGSJ-UHFFFAOYSA-N 474218 3-(2,2-dimethylmorpholino)-7-(4- methoxybenzyl)-6- methylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 98::US10905688, Example 98::US11472810, Example 98 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 287 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474218 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474218&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652493 442074415 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983594 Fc1cccc(Cn2c(Cc3ccccc3)cn3c(ncc3c2=O)C2CCOCC2)c1 InChI=1S/C25H24FN3O2/c26-21-8-4-7-19(13-21)16-28-22(14-18-5-2-1-3-6-18)17-29-23(25(28)30)15-27-24(29)20-9-11-31-12-10-20/h1-8,13,15,17,20H,9-12,14,16H2 NTXQTICQWIKNOO-UHFFFAOYSA-N 474109 6-Benzyl-7-(3-fluorobenzyl)-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 2::US10912773, Example 2::US11472810, Example 2 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 10000 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474109&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652351 442074308 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983595 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)[C@@H]1CCCOC1 InChI=1S/C19H20FN3O2/c1-13-10-23-17(9-21-18(23)15-5-3-7-25-12-15)19(24)22(13)11-14-4-2-6-16(20)8-14/h2,4,6,8-10,15H,3,5,7,11-12H2,1H3/t15-/m1/s1 PZKOOBRKCGIRJF-OAHLLOKOSA-N 474219 7-(3-fluorobenzyl)-6-methyl-3- (tetrahydro-2H-pyran-3- yl)imidazo[1,5-a]pyrazin-8(7H)- one, stereoisomer 1::US10858362, Example 100, isomer 1::US10905688, Example 100, isomer 1::US11472810, Example 100, isomer 1 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 306 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474219 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474219&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652485 442074416 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983598 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)[C@H]1CCCOC1 InChI=1S/C19H20FN3O2/c1-13-10-23-17(9-21-18(23)15-5-3-7-25-12-15)19(24)22(13)11-14-4-2-6-16(20)8-14/h2,4,6,8-10,15H,3,5,7,11-12H2,1H3/t15-/m0/s1 PZKOOBRKCGIRJF-HNNXBMFYSA-N 474220 7-(3-fluorobenzyl)-6-methyl-3- (tetrahydro-2H-pyran-3- yl)imidazo[1,5-a]pyrazin-8(7H)- one, stereoisomer 2::US10858362, Example 100, isomer 2::US10905688, Example 100, isomer 2::US11472810, Example 100, isomer 2 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 333 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474220 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474220&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652422 442074417 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51328758 CC[C@@]12CCCN3CCc4c([C@H]13)n(C(CO)=C2)c1ccccc41 InChI=1S/C20H24N2O/c1-2-20-9-5-10-21-11-8-16-15-6-3-4-7-17(15)22(14(12-20)13-23)18(16)19(20)21/h3-4,6-7,12,19,23H,2,5,8-11,13H2,1H3/t19-,20+/m1/s1 FSCZUIZDBMJVDY-UXHICEINSA-N 50537766 CHEMBL4646903 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 24320 ChEMBL 10.1016/j.bmcl.2019.05.052 10.7270/Q2VX0M21 31859156 Pan, BW; Shi, Y; Li, WC; Wang, Q; Pan, M; Wu, Q; Fu, HZ Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537766 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537766&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 12306934 442139329 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51328759 CC[C@@]12CCCN3CCc4c([C@H]13)n(C(COC(=S)Nc1ccccc1)=C2)c1ccccc41 InChI=1S/C27H29N3OS/c1-2-27-14-8-15-29-16-13-22-21-11-6-7-12-23(21)30(24(22)25(27)29)20(17-27)18-31-26(32)28-19-9-4-3-5-10-19/h3-7,9-12,17,25H,2,8,13-16,18H2,1H3,(H,28,32)/t25-,27+/m1/s1 OSRGPTRUQNJQNB-VPUSJEBWSA-N 50537767 CHEMBL4639072 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 24770 ChEMBL 10.1016/j.bmcl.2019.05.052 10.7270/Q2VX0M21 31859156 Pan, BW; Shi, Y; Li, WC; Wang, Q; Pan, M; Wu, Q; Fu, HZ Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537767 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537767&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 156013253 442139330 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51328760 CC[C@@]12CCCN3CCc4c([C@H]13)n(C(COC(=S)NC)=C2)c1ccccc41 InChI=1S/C22H27N3OS/c1-3-22-10-6-11-24-12-9-17-16-7-4-5-8-18(16)25(19(17)20(22)24)15(13-22)14-26-21(27)23-2/h4-5,7-8,13,20H,3,6,9-12,14H2,1-2H3,(H,23,27)/t20-,22+/m1/s1 CCPUIFJVAYRRAS-IRLDBZIGSA-N 50537768 CHEMBL4649020 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 30890 ChEMBL 10.1016/j.bmcl.2019.05.052 10.7270/Q2VX0M21 31859156 Pan, BW; Shi, Y; Li, WC; Wang, Q; Pan, M; Wu, Q; Fu, HZ Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537768 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537768&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 156020637 442139331 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51328761 CC[C@@]12CCCN3CCc4c([C@H]13)n(C(COC(=S)Nc1ccc(cc1)C(F)(F)F)=C2)c1ccccc41 InChI=1S/C28H28F3N3OS/c1-2-27-13-5-14-33-15-12-22-21-6-3-4-7-23(21)34(24(22)25(27)33)20(16-27)17-35-26(36)32-19-10-8-18(9-11-19)28(29,30)31/h3-4,6-11,16,25H,2,5,12-15,17H2,1H3,(H,32,36)/t25-,27+/m1/s1 SDCXMWMUMBKYFK-VPUSJEBWSA-N 50537769 CHEMBL4635813 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 64080 ChEMBL 10.1016/j.bmcl.2019.05.052 10.7270/Q2VX0M21 31859156 Pan, BW; Shi, Y; Li, WC; Wang, Q; Pan, M; Wu, Q; Fu, HZ Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537769 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537769&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 156014289 442139332 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51328762 CC[C@@]12CCCN3CCc4c([C@H]13)n(C(COC(=S)NC1CCCCC1)=C2)c1ccccc41 InChI=1S/C27H35N3OS/c1-2-27-14-8-15-29-16-13-22-21-11-6-7-12-23(21)30(24(22)25(27)29)20(17-27)18-31-26(32)28-19-9-4-3-5-10-19/h6-7,11-12,17,19,25H,2-5,8-10,13-16,18H2,1H3,(H,28,32)/t25-,27+/m1/s1 NOTHFSPZIZCNBI-VPUSJEBWSA-N 50537770 CHEMBL4642086 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8060 ChEMBL 10.1016/j.bmcl.2019.05.052 10.7270/Q2VX0M21 31859156 Pan, BW; Shi, Y; Li, WC; Wang, Q; Pan, M; Wu, Q; Fu, HZ Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537770 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537770&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 156016212 442139333 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51328763 CC[C@@]12CCCN3CCc4c([C@H]13)n(C(COC(=S)NC(C)C)=C2)c1ccccc41 InChI=1S/C24H31N3OS/c1-4-24-11-7-12-26-13-10-19-18-8-5-6-9-20(18)27(21(19)22(24)26)17(14-24)15-28-23(29)25-16(2)3/h5-6,8-9,14,16,22H,4,7,10-13,15H2,1-3H3,(H,25,29)/t22-,24+/m1/s1 ZGAQWRGIYPJLEP-VWNXMTODSA-N 50537771 CHEMBL4632510 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 12950 ChEMBL 10.1016/j.bmcl.2019.05.052 10.7270/Q2VX0M21 31859156 Pan, BW; Shi, Y; Li, WC; Wang, Q; Pan, M; Wu, Q; Fu, HZ Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537771&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 156010139 442139334 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51328764 CC[C@@]12CCCN3CCc4c([C@H]13)n(C(COC(=S)Nc1ccc(F)cc1)=C2)c1ccccc41 InChI=1S/C27H28FN3OS/c1-2-27-13-5-14-30-15-12-22-21-6-3-4-7-23(21)31(24(22)25(27)30)20(16-27)17-32-26(33)29-19-10-8-18(28)9-11-19/h3-4,6-11,16,25H,2,5,12-15,17H2,1H3,(H,29,33)/t25-,27+/m1/s1 WJOSNRVWQAFNHU-VPUSJEBWSA-N 50537772 CHEMBL4633023 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 3680 ChEMBL 10.1016/j.bmcl.2019.05.052 10.7270/Q2VX0M21 31859156 Pan, BW; Shi, Y; Li, WC; Wang, Q; Pan, M; Wu, Q; Fu, HZ Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537772&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 156010474 442139335 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51328765 CC[C@@]12CCCN3CCc4c([C@H]13)n(C(COC(=S)Nc1ccc(F)cc1F)=C2)c1ccccc41 InChI=1S/C27H27F2N3OS/c1-2-27-11-5-12-31-13-10-20-19-6-3-4-7-23(19)32(24(20)25(27)31)18(15-27)16-33-26(34)30-22-9-8-17(28)14-21(22)29/h3-4,6-9,14-15,25H,2,5,10-13,16H2,1H3,(H,30,34)/t25-,27+/m1/s1 PRNISMHDFBXXFI-VPUSJEBWSA-N 50537773 CHEMBL4641656 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 12480 ChEMBL 10.1016/j.bmcl.2019.05.052 10.7270/Q2VX0M21 31859156 Pan, BW; Shi, Y; Li, WC; Wang, Q; Pan, M; Wu, Q; Fu, HZ Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537773&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 156016186 442139336 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51328766 CC[C@@]12CCCN3CCc4c([C@H]13)n(C(COC(=S)Nc1ccc(OC)cc1)=C2)c1ccccc41 InChI=1S/C28H31N3O2S/c1-3-28-14-6-15-30-16-13-23-22-7-4-5-8-24(22)31(25(23)26(28)30)20(17-28)18-33-27(34)29-19-9-11-21(32-2)12-10-19/h4-5,7-12,17,26H,3,6,13-16,18H2,1-2H3,(H,29,34)/t26-,28+/m1/s1 GJLAVECGVUZJAE-IAPPQJPRSA-N 50537774 CHEMBL4640085 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 19520 ChEMBL 10.1016/j.bmcl.2019.05.052 10.7270/Q2VX0M21 31859156 Pan, BW; Shi, Y; Li, WC; Wang, Q; Pan, M; Wu, Q; Fu, HZ Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537774 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537774&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 156015831 442139337 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51328767 CC[C@@]12CCCN3CCc4c([C@H]13)n(C(COC(=S)Nc1cccc(OC)c1)=C2)c1ccccc41 InChI=1S/C28H31N3O2S/c1-3-28-13-7-14-30-15-12-23-22-10-4-5-11-24(22)31(25(23)26(28)30)20(17-28)18-33-27(34)29-19-8-6-9-21(16-19)32-2/h4-6,8-11,16-17,26H,3,7,12-15,18H2,1-2H3,(H,29,34)/t26-,28+/m1/s1 NACYSIMTPZYSRO-IAPPQJPRSA-N 50537775 CHEMBL4633680 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 18590 ChEMBL 10.1016/j.bmcl.2019.05.052 10.7270/Q2VX0M21 31859156 Pan, BW; Shi, Y; Li, WC; Wang, Q; Pan, M; Wu, Q; Fu, HZ Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537775 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537775&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 156011113 442139338 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51328768 CC[C@@]12CCCN3CCc4c([C@H]13)n(C(COC(=S)Nc1ccc(Cl)cc1)=C2)c1ccccc41 InChI=1S/C27H28ClN3OS/c1-2-27-13-5-14-30-15-12-22-21-6-3-4-7-23(21)31(24(22)25(27)30)20(16-27)17-32-26(33)29-19-10-8-18(28)9-11-19/h3-4,6-11,16,25H,2,5,12-15,17H2,1H3,(H,29,33)/t25-,27+/m1/s1 OITYKNRSRKZAOQ-VPUSJEBWSA-N 50537776 CHEMBL4649811 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 67350 ChEMBL 10.1016/j.bmcl.2019.05.052 10.7270/Q2VX0M21 31859156 Pan, BW; Shi, Y; Li, WC; Wang, Q; Pan, M; Wu, Q; Fu, HZ Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537776 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537776&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 156022181 442139339 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51328769 CC[C@@]12CCCN3CCc4c([C@H]13)n(C(COC(=S)Nc1ccccc1Br)=C2)c1ccccc41 InChI=1S/C27H28BrN3OS/c1-2-27-13-7-14-30-15-12-20-19-8-3-6-11-23(19)31(24(20)25(27)30)18(16-27)17-32-26(33)29-22-10-5-4-9-21(22)28/h3-6,8-11,16,25H,2,7,12-15,17H2,1H3,(H,29,33)/t25-,27+/m1/s1 UFLNKLMDIVOQAA-VPUSJEBWSA-N 50537777 CHEMBL4640548 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 51970 ChEMBL 10.1016/j.bmcl.2019.05.052 10.7270/Q2VX0M21 31859156 Pan, BW; Shi, Y; Li, WC; Wang, Q; Pan, M; Wu, Q; Fu, HZ Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537777 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537777&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 156015289 442139340 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51328770 CC[C@@]12CCCN3CCc4c([C@H]13)n(C(COC(=S)Nc1cccc3ccccc13)=C2)c1ccccc41 InChI=1S/C31H31N3OS/c1-2-31-16-8-17-33-18-15-25-24-12-5-6-14-27(24)34(28(25)29(31)33)22(19-31)20-35-30(36)32-26-13-7-10-21-9-3-4-11-23(21)26/h3-7,9-14,19,29H,2,8,15-18,20H2,1H3,(H,32,36)/t29-,31+/m1/s1 KMXSEKYVDFGBAT-VEEOACQBSA-N 50537778 CHEMBL4643153 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 58430 ChEMBL 10.1016/j.bmcl.2019.05.052 10.7270/Q2VX0M21 31859156 Pan, BW; Shi, Y; Li, WC; Wang, Q; Pan, M; Wu, Q; Fu, HZ Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537778 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537778&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 156018524 442139341 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51328771 CC[C@@]12CCCN3CCc4c([C@H]13)n(C(COC(=S)NCc1ccccc1)=C2)c1ccccc41 InChI=1S/C28H31N3OS/c1-2-28-14-8-15-30-16-13-23-22-11-6-7-12-24(22)31(25(23)26(28)30)21(17-28)19-32-27(33)29-18-20-9-4-3-5-10-20/h3-7,9-12,17,26H,2,8,13-16,18-19H2,1H3,(H,29,33)/t26-,28+/m1/s1 UOMQRXKNLJCZSQ-IAPPQJPRSA-N 50537779 CHEMBL4643016 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 38250 ChEMBL 10.1016/j.bmcl.2019.05.052 10.7270/Q2VX0M21 31859156 Pan, BW; Shi, Y; Li, WC; Wang, Q; Pan, M; Wu, Q; Fu, HZ Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537779&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 156016824 442139342 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51328772 CC[C@@]12CCCN3CCc4c([C@H]13)n(C(COC(=S)Nc1ccccc1Cl)=C2)c1ccccc41 InChI=1S/C27H28ClN3OS/c1-2-27-13-7-14-30-15-12-20-19-8-3-6-11-23(19)31(24(20)25(27)30)18(16-27)17-32-26(33)29-22-10-5-4-9-21(22)28/h3-6,8-11,16,25H,2,7,12-15,17H2,1H3,(H,29,33)/t25-,27+/m1/s1 XLVPOHUZLJDPJE-VPUSJEBWSA-N 50537780 CHEMBL4639100 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 65800 ChEMBL 10.1016/j.bmcl.2019.05.052 10.7270/Q2VX0M21 31859156 Pan, BW; Shi, Y; Li, WC; Wang, Q; Pan, M; Wu, Q; Fu, HZ Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537780 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537780&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 156013406 442139343 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51328773 CC[C@@]12CCCN3CCc4c([C@H]13)n(C(COC(=S)Nc1cccc(Cl)c1)=C2)c1ccccc41 InChI=1S/C27H28ClN3OS/c1-2-27-12-6-13-30-14-11-22-21-9-3-4-10-23(21)31(24(22)25(27)30)20(16-27)17-32-26(33)29-19-8-5-7-18(28)15-19/h3-5,7-10,15-16,25H,2,6,11-14,17H2,1H3,(H,29,33)/t25-,27+/m1/s1 XLXFXNJVTHNGPO-VPUSJEBWSA-N 50537781 CHEMBL4636207 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 72020 ChEMBL 10.1016/j.bmcl.2019.05.052 10.7270/Q2VX0M21 31859156 Pan, BW; Shi, Y; Li, WC; Wang, Q; Pan, M; Wu, Q; Fu, HZ Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537781 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537781&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 156013754 442139344 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51328774 CC[C@@]12CCCN3CCc4c([C@H]13)n(C(COC(=S)Nc1cccc(C)c1)=C2)c1ccccc41 InChI=1S/C28H31N3OS/c1-3-28-13-7-14-30-15-12-23-22-10-4-5-11-24(22)31(25(23)26(28)30)21(17-28)18-32-27(33)29-20-9-6-8-19(2)16-20/h4-6,8-11,16-17,26H,3,7,12-15,18H2,1-2H3,(H,29,33)/t26-,28+/m1/s1 SCPYGQFMZOBJLW-IAPPQJPRSA-N 50537782 CHEMBL4643199 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 39910 ChEMBL 10.1016/j.bmcl.2019.05.052 10.7270/Q2VX0M21 31859156 Pan, BW; Shi, Y; Li, WC; Wang, Q; Pan, M; Wu, Q; Fu, HZ Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537782 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537782&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 156018878 442139345 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51328775 CC[C@@]12CCCN3CCc4c([C@H]13)n(C(COC(=S)Nc1ccccc1C)=C2)c1ccccc41 InChI=1S/C28H31N3OS/c1-3-28-14-8-15-30-16-13-22-21-10-5-7-12-24(21)31(25(22)26(28)30)20(17-28)18-32-27(33)29-23-11-6-4-9-19(23)2/h4-7,9-12,17,26H,3,8,13-16,18H2,1-2H3,(H,29,33)/t26-,28+/m1/s1 LZPWCLWSFNYGAE-IAPPQJPRSA-N 50537783 CHEMBL4638154 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 41100 ChEMBL 10.1016/j.bmcl.2019.05.052 10.7270/Q2VX0M21 31859156 Pan, BW; Shi, Y; Li, WC; Wang, Q; Pan, M; Wu, Q; Fu, HZ Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537783 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537783&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 156012491 442139346 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51328776 CC[C@@]12CCCN3CCc4c([C@H]13)n(C(COC(=S)Nc1cccc(c1)C(F)(F)F)=C2)c1ccccc41 InChI=1S/C28H28F3N3OS/c1-2-27-12-6-13-33-14-11-22-21-9-3-4-10-23(21)34(24(22)25(27)33)20(16-27)17-35-26(36)32-19-8-5-7-18(15-19)28(29,30)31/h3-5,7-10,15-16,25H,2,6,11-14,17H2,1H3,(H,32,36)/t25-,27+/m1/s1 WPLCPJRUWZWKHC-VPUSJEBWSA-N 50537784 CHEMBL4648949 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 62460 ChEMBL 10.1016/j.bmcl.2019.05.052 10.7270/Q2VX0M21 31859156 Pan, BW; Shi, Y; Li, WC; Wang, Q; Pan, M; Wu, Q; Fu, HZ Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537784 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537784&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 156021527 442139347 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51328777 CC[C@@]12CCCN3CCc4c([C@H]13)n(C(COC(=S)Nc1cccc(F)c1)=C2)c1ccccc41 InChI=1S/C27H28FN3OS/c1-2-27-12-6-13-30-14-11-22-21-9-3-4-10-23(21)31(24(22)25(27)30)20(16-27)17-32-26(33)29-19-8-5-7-18(28)15-19/h3-5,7-10,15-16,25H,2,6,11-14,17H2,1H3,(H,29,33)/t25-,27+/m1/s1 GVCRMZAQTVDYHO-VPUSJEBWSA-N 50537785 CHEMBL4645801 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 3860 ChEMBL 10.1016/j.bmcl.2019.05.052 10.7270/Q2VX0M21 31859156 Pan, BW; Shi, Y; Li, WC; Wang, Q; Pan, M; Wu, Q; Fu, HZ Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537785 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537785&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 156019416 442139348 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51328778 CC[C@@]12CCCN3CCc4c([C@H]13)n(C(COC(=S)Nc1ccccc1F)=C2)c1ccccc41 InChI=1S/C27H28FN3OS/c1-2-27-13-7-14-30-15-12-20-19-8-3-6-11-23(19)31(24(20)25(27)30)18(16-27)17-32-26(33)29-22-10-5-4-9-21(22)28/h3-6,8-11,16,25H,2,7,12-15,17H2,1H3,(H,29,33)/t25-,27+/m1/s1 POXUJABYWYTPHJ-VPUSJEBWSA-N 50537786 CHEMBL4639838 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 6240 ChEMBL 10.1016/j.bmcl.2019.05.052 10.7270/Q2VX0M21 31859156 Pan, BW; Shi, Y; Li, WC; Wang, Q; Pan, M; Wu, Q; Fu, HZ Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537786&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 156015669 442139349 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51328779 CC[C@@]12CCCN3CCc4c([C@H]13)n(C(COC(=S)Nc1ccc(SC)cc1)=C2)c1ccccc41 InChI=1S/C28H31N3OS2/c1-3-28-14-6-15-30-16-13-23-22-7-4-5-8-24(22)31(25(23)26(28)30)20(17-28)18-32-27(33)29-19-9-11-21(34-2)12-10-19/h4-5,7-12,17,26H,3,6,13-16,18H2,1-2H3,(H,29,33)/t26-,28+/m1/s1 MKOJMUIIIQHWMQ-IAPPQJPRSA-N 50537787 CHEMBL4635828 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 19040 ChEMBL 10.1016/j.bmcl.2019.05.052 10.7270/Q2VX0M21 31859156 Pan, BW; Shi, Y; Li, WC; Wang, Q; Pan, M; Wu, Q; Fu, HZ Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537787&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 156014370 442139350 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51328780 CC[C@@]12CCCN3CCc4c([C@H]13)n(C(COC(=S)Nc1ccc(OC)cc1OC)=C2)c1ccccc41 InChI=1S/C29H33N3O3S/c1-4-29-13-7-14-31-15-12-22-21-8-5-6-9-24(21)32(26(22)27(29)31)19(17-29)18-35-28(36)30-23-11-10-20(33-2)16-25(23)34-3/h5-6,8-11,16-17,27H,4,7,12-15,18H2,1-3H3,(H,30,36)/t27-,29+/m1/s1 LHIDLRYKUSGCLC-PXJZQJOASA-N 50537788 CHEMBL4644704 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 74360 ChEMBL 10.1016/j.bmcl.2019.05.052 10.7270/Q2VX0M21 31859156 Pan, BW; Shi, Y; Li, WC; Wang, Q; Pan, M; Wu, Q; Fu, HZ Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537788&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 156017735 442139351 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51328781 CC[C@@]12CCCN3CCc4c([C@H]13)n(C(COC(=S)Nc1ccc(Br)cc1)=C2)c1ccccc41 InChI=1S/C27H28BrN3OS/c1-2-27-13-5-14-30-15-12-22-21-6-3-4-7-23(21)31(24(22)25(27)30)20(16-27)17-32-26(33)29-19-10-8-18(28)9-11-19/h3-4,6-11,16,25H,2,5,12-15,17H2,1H3,(H,29,33)/t25-,27+/m1/s1 FBFFKROFZXOLDE-VPUSJEBWSA-N 50537789 CHEMBL4644378 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 49290 ChEMBL 10.1016/j.bmcl.2019.05.052 10.7270/Q2VX0M21 31859156 Pan, BW; Shi, Y; Li, WC; Wang, Q; Pan, M; Wu, Q; Fu, HZ Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537789&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 156018586 442139352 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51328782 CC[C@@]12CCCN3CCc4c([C@H]13)n(C(COC(=S)Nc1cccc(Cl)c1Cl)=C2)c1ccccc41 InChI=1S/C27H27Cl2N3OS/c1-2-27-12-6-13-31-14-11-19-18-7-3-4-10-22(18)32(24(19)25(27)31)17(15-27)16-33-26(34)30-21-9-5-8-20(28)23(21)29/h3-5,7-10,15,25H,2,6,11-14,16H2,1H3,(H,30,34)/t25-,27+/m1/s1 HHVHDSBCDPXJJL-VPUSJEBWSA-N 50537790 CHEMBL4639361 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 56300 ChEMBL 10.1016/j.bmcl.2019.05.052 10.7270/Q2VX0M21 31859156 Pan, BW; Shi, Y; Li, WC; Wang, Q; Pan, M; Wu, Q; Fu, HZ Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537790&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 156013158 442139353 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51328783 CC[C@@]12CCCN3CCc4c([C@H]13)n(C(COC(=S)Nc1ccc(cc1)C(C)(C)C)=C2)c1ccccc41 InChI=1S/C31H37N3OS/c1-5-31-16-8-17-33-18-15-25-24-9-6-7-10-26(24)34(27(25)28(31)33)23(19-31)20-35-29(36)32-22-13-11-21(12-14-22)30(2,3)4/h6-7,9-14,19,28H,5,8,15-18,20H2,1-4H3,(H,32,36)/t28-,31+/m1/s1 DHKMHTMLKNTJPK-MVSFAKPFSA-N 50537791 CHEMBL4640039 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 12060 ChEMBL 10.1016/j.bmcl.2019.05.052 10.7270/Q2VX0M21 31859156 Pan, BW; Shi, Y; Li, WC; Wang, Q; Pan, M; Wu, Q; Fu, HZ Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537791&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 156015577 442139354 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51328784 CC[C@@]12CCCN3CCc4c([C@H]13)n(C(CO\C(SC)=N\c1ccc(C)cc1)=C2)c1ccccc41 InChI=1S/C29H33N3OS/c1-4-29-15-7-16-31-17-14-24-23-8-5-6-9-25(23)32(26(24)27(29)31)22(18-29)19-33-28(34-3)30-21-12-10-20(2)11-13-21/h5-6,8-13,18,27H,4,7,14-17,19H2,1-3H3/b30-28-/t27-,29+/m1/s1 ZYRKUVFTSPIBBP-LPMJPCMRSA-N 50537792 CHEMBL4638576 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 12250 ChEMBL 10.1016/j.bmcl.2019.05.052 10.7270/Q2VX0M21 31859156 Pan, BW; Shi, Y; Li, WC; Wang, Q; Pan, M; Wu, Q; Fu, HZ Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537792&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 156011745 442139355 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51328785 CC[C@@]12CCCN3CCc4c([C@H]13)n(C(CO\C(SC)=N\c1ccc(F)cc1)=C2)c1ccccc41 InChI=1S/C28H30FN3OS/c1-3-28-14-6-15-31-16-13-23-22-7-4-5-8-24(22)32(25(23)26(28)31)21(17-28)18-33-27(34-2)30-20-11-9-19(29)10-12-20/h4-5,7-12,17,26H,3,6,13-16,18H2,1-2H3/b30-27-/t26-,28+/m1/s1 PPRUYTARHWYAHC-IXUGJBATSA-N 50537793 CHEMBL4633277 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 30090 ChEMBL 10.1016/j.bmcl.2019.05.052 10.7270/Q2VX0M21 31859156 Pan, BW; Shi, Y; Li, WC; Wang, Q; Pan, M; Wu, Q; Fu, HZ Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537793&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 156010251 442139356 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51328786 CC[C@@]12CCCN3CCc4c([C@H]13)n(C(CO\C(SC)=N\c1cccc(F)c1)=C2)c1ccccc41 InChI=1S/C28H30FN3OS/c1-3-28-13-7-14-31-15-12-23-22-10-4-5-11-24(22)32(25(23)26(28)31)21(17-28)18-33-27(34-2)30-20-9-6-8-19(29)16-20/h4-6,8-11,16-17,26H,3,7,12-15,18H2,1-2H3/b30-27-/t26-,28+/m1/s1 INJGVYQYSAACJC-IXUGJBATSA-N 50537794 CHEMBL4644211 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 30660 ChEMBL 10.1016/j.bmcl.2019.05.052 10.7270/Q2VX0M21 31859156 Pan, BW; Shi, Y; Li, WC; Wang, Q; Pan, M; Wu, Q; Fu, HZ Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537794&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 156018802 442139357 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51328787 CC[C@@]12CCCN3CCc4c([C@H]13)n(C(CO\C(SC)=N\c1ccccc1F)=C2)c1ccccc41 InChI=1S/C28H30FN3OS/c1-3-28-14-8-15-31-16-13-21-20-9-4-7-12-24(20)32(25(21)26(28)31)19(17-28)18-33-27(34-2)30-23-11-6-5-10-22(23)29/h4-7,9-12,17,26H,3,8,13-16,18H2,1-2H3/b30-27-/t26-,28+/m1/s1 DUGYESQMPMYCNP-IXUGJBATSA-N 50537795 CHEMBL4638744 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 26160 ChEMBL 10.1016/j.bmcl.2019.05.052 10.7270/Q2VX0M21 31859156 Pan, BW; Shi, Y; Li, WC; Wang, Q; Pan, M; Wu, Q; Fu, HZ Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537795&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 156012876 442139358 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51328788 CC[C@@]12CCCN3CCc4c([C@H]13)n(C(COC(=S)N(C(=O)c1ccccc1)c1ccccc1)=C2)c1ccccc41 InChI=1S/C34H33N3O2S/c1-2-34-19-11-20-35-21-18-28-27-16-9-10-17-29(27)36(30(28)31(34)35)26(22-34)23-39-33(40)37(25-14-7-4-8-15-25)32(38)24-12-5-3-6-13-24/h3-10,12-17,22,31H,2,11,18-21,23H2,1H3/t31-,34+/m1/s1 YRVJXGXRMUFRFN-FJQKOURKSA-N 50537796 CHEMBL4633805 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 47640 ChEMBL 10.1016/j.bmcl.2019.05.052 10.7270/Q2VX0M21 31859156 Pan, BW; Shi, Y; Li, WC; Wang, Q; Pan, M; Wu, Q; Fu, HZ Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537796&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 156009532 442139359 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51328789 CC[C@@]12CCCN3CCc4c([C@H]13)n(C(COC(=S)N(C(=O)C1CC1)c1ccccc1)=C2)c1ccccc41 InChI=1S/C31H33N3O2S/c1-2-31-16-8-17-32-18-15-25-24-11-6-7-12-26(24)33(27(25)28(31)32)23(19-31)20-36-30(37)34(29(35)21-13-14-21)22-9-4-3-5-10-22/h3-7,9-12,19,21,28H,2,8,13-18,20H2,1H3/t28-,31+/m1/s1 NRKHVUXQDDELGQ-MVSFAKPFSA-N 50537797 CHEMBL4643200 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 60170 ChEMBL 10.1016/j.bmcl.2019.05.052 10.7270/Q2VX0M21 31859156 Pan, BW; Shi, Y; Li, WC; Wang, Q; Pan, M; Wu, Q; Fu, HZ Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537797&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 156018879 442139360 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51328790 CC[C@@]12CCCN3CCc4c([C@H]13)n(C(COC(=S)N(C(=O)N1CCOCC1)c1ccccc1)=C2)c1ccccc41 InChI=1S/C32H36N4O3S/c1-2-32-14-8-15-33-16-13-26-25-11-6-7-12-27(25)35(28(26)29(32)33)24(21-32)22-39-31(40)36(23-9-4-3-5-10-23)30(37)34-17-19-38-20-18-34/h3-7,9-12,21,29H,2,8,13-20,22H2,1H3/t29-,32+/m1/s1 WLKAAHFCWMYOLP-PPTMTGTBSA-N 50537798 CHEMBL4637690 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8420 ChEMBL 10.1016/j.bmcl.2019.05.052 10.7270/Q2VX0M21 31859156 Pan, BW; Shi, Y; Li, WC; Wang, Q; Pan, M; Wu, Q; Fu, HZ Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537798&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 156012779 442139361 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51328791 CC[C@@]12CCCN3CCc4c([C@H]13)n(C(CN1C(=O)c3ccccc3C1=O)=C2)c1ccccc41 InChI=1S/C28H27N3O2/c1-2-28-13-7-14-29-15-12-20-19-8-5-6-11-23(19)31(24(20)25(28)29)18(16-28)17-30-26(32)21-9-3-4-10-22(21)27(30)33/h3-6,8-11,16,25H,2,7,12-15,17H2,1H3/t25-,28+/m1/s1 CQJLVFWZQPGYMB-NAKRPHOHSA-N 50537799 CHEMBL4633185 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 50030 ChEMBL 10.1016/j.bmcl.2019.05.052 10.7270/Q2VX0M21 31859156 Pan, BW; Shi, Y; Li, WC; Wang, Q; Pan, M; Wu, Q; Fu, HZ Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537799&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 11729833 442139362 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51328792 CC[C@@]12CCCN3CCc4c([C@H]13)n(C(CN)=C2)c1ccccc41 InChI=1S/C20H25N3/c1-2-20-9-5-10-22-11-8-16-15-6-3-4-7-17(15)23(14(12-20)13-21)18(16)19(20)22/h3-4,6-7,12,19H,2,5,8-11,13,21H2,1H3/t19-,20+/m1/s1 DKDARGJYBMQJOC-UXHICEINSA-N 50537800 CHEMBL4642588 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 33240 ChEMBL 10.1016/j.bmcl.2019.05.052 10.7270/Q2VX0M21 31859156 Pan, BW; Shi, Y; Li, WC; Wang, Q; Pan, M; Wu, Q; Fu, HZ Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537800&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 11045023 442139363 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51328793 CC[C@@]12CCCN3CCc4c([C@H]13)n(C(CNC(=S)NC(=O)c1ccccc1)=C2)c1ccccc41 InChI=1S/C28H30N4OS/c1-2-28-14-8-15-31-16-13-22-21-11-6-7-12-23(21)32(24(22)25(28)31)20(17-28)18-29-27(34)30-26(33)19-9-4-3-5-10-19/h3-7,9-12,17,25H,2,8,13-16,18H2,1H3,(H2,29,30,33,34)/t25-,28+/m1/s1 SJBZNXLQOHWAEQ-NAKRPHOHSA-N 50537801 CHEMBL4643607 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 64240 ChEMBL 10.1016/j.bmcl.2019.05.052 10.7270/Q2VX0M21 31859156 Pan, BW; Shi, Y; Li, WC; Wang, Q; Pan, M; Wu, Q; Fu, HZ Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537801&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 156018549 442139364 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51328794 CC[C@@]12CCCN3CCc4c([C@H]13)n(C(CNC(=S)NC(=O)c1ccc(F)cc1)=C2)c1ccccc41 InChI=1S/C28H29FN4OS/c1-2-28-13-5-14-32-15-12-22-21-6-3-4-7-23(21)33(24(22)25(28)32)20(16-28)17-30-27(35)31-26(34)18-8-10-19(29)11-9-18/h3-4,6-11,16,25H,2,5,12-15,17H2,1H3,(H2,30,31,34,35)/t25-,28+/m1/s1 RTQLWHZAEOBSAJ-NAKRPHOHSA-N 50537802 CHEMBL4636663 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 26280 ChEMBL 10.1016/j.bmcl.2019.05.052 10.7270/Q2VX0M21 31859156 Pan, BW; Shi, Y; Li, WC; Wang, Q; Pan, M; Wu, Q; Fu, HZ Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537802 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537802&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 156012523 442139365 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51328795 CC[C@@]12CCCN3CCc4c([C@H]13)n(C(CNC(=S)NC(=O)c1ccc(OC)cc1)=C2)c1ccccc41 InChI=1S/C29H32N4O2S/c1-3-29-14-6-15-32-16-13-23-22-7-4-5-8-24(22)33(25(23)26(29)32)20(17-29)18-30-28(36)31-27(34)19-9-11-21(35-2)12-10-19/h4-5,7-12,17,26H,3,6,13-16,18H2,1-2H3,(H2,30,31,34,36)/t26-,29+/m1/s1 UGUZCEQAYOPFLN-UHSQPCAPSA-N 50537803 CHEMBL4633227 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 17030 ChEMBL 10.1016/j.bmcl.2019.05.052 10.7270/Q2VX0M21 31859156 Pan, BW; Shi, Y; Li, WC; Wang, Q; Pan, M; Wu, Q; Fu, HZ Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537803 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537803&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 156009493 442139366 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51328796 CCOC(=O)NC(=S)NCC1=C[C@]2(CC)CCCN3CCc4c([C@H]23)n1c1ccccc41 InChI=1S/C24H30N4O2S/c1-3-24-11-7-12-27-13-10-18-17-8-5-6-9-19(17)28(20(18)21(24)27)16(14-24)15-25-22(31)26-23(29)30-4-2/h5-6,8-9,14,21H,3-4,7,10-13,15H2,1-2H3,(H2,25,26,29,31)/t21-,24+/m1/s1 WFENYEJLVHBUFZ-QPPBQGQZSA-N 50537804 CHEMBL4648572 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 49250 ChEMBL 10.1016/j.bmcl.2019.05.052 10.7270/Q2VX0M21 31859156 Pan, BW; Shi, Y; Li, WC; Wang, Q; Pan, M; Wu, Q; Fu, HZ Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537804 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537804&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 156021051 442139367 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51328797 CC[C@@]12CCCN3CCc4c([C@H]13)n(C(CNC(=S)Nc1ccccc1)=C2)c1ccccc41 InChI=1S/C27H30N4S/c1-2-27-14-8-15-30-16-13-22-21-11-6-7-12-23(21)31(24(22)25(27)30)20(17-27)18-28-26(32)29-19-9-4-3-5-10-19/h3-7,9-12,17,25H,2,8,13-16,18H2,1H3,(H2,28,29,32)/t25-,27+/m1/s1 VZDPVDKCYZRUQJ-VPUSJEBWSA-N 50537805 CHEMBL4646556 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 64670 ChEMBL 10.1016/j.bmcl.2019.05.052 10.7270/Q2VX0M21 31859156 Pan, BW; Shi, Y; Li, WC; Wang, Q; Pan, M; Wu, Q; Fu, HZ Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537805 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537805&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 156019583 442139368 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51328798 CC[C@@]12CCCN3CCc4c([C@H]13)n(C(CNC(=S)Nc1ccc(Cl)cc1)=C2)c1ccccc41 InChI=1S/C27H29ClN4S/c1-2-27-13-5-14-31-15-12-22-21-6-3-4-7-23(21)32(24(22)25(27)31)20(16-27)17-29-26(33)30-19-10-8-18(28)9-11-19/h3-4,6-11,16,25H,2,5,12-15,17H2,1H3,(H2,29,30,33)/t25-,27+/m1/s1 ZUBAGCFQKUERTB-VPUSJEBWSA-N 50537806 CHEMBL4643091 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 16390 ChEMBL 10.1016/j.bmcl.2019.05.052 10.7270/Q2VX0M21 31859156 Pan, BW; Shi, Y; Li, WC; Wang, Q; Pan, M; Wu, Q; Fu, HZ Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537806 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537806&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 156016247 442139369 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51328799 CCOC(=O)C1=C[C@]2(CC)CCCN3CCc4c([C@H]23)n1c1ccccc41 InChI=1S/C22H26N2O2/c1-3-22-11-7-12-23-13-10-16-15-8-5-6-9-17(15)24(19(16)20(22)23)18(14-22)21(25)26-4-2/h5-6,8-9,14,20H,3-4,7,10-13H2,1-2H3/t20-,22+/m1/s1 DDNCQMVWWZOMLN-IRLDBZIGSA-N 50059033 (11aS,11bS)-11a-Ethyl-2,3,4,5,11a,11b-hexahydro-1H-3a,9b-diaza-benzo[cd]fluoranthene-10-carboxylic acid ethyl ester::(3S,16S)-apovincaminic acid ethylester::(3aS,11bS)-3a-ethyl-1,2,3,3a,10,11b-hexahydro-11H-5a,11a-diaza-benzo[cd]fluoranthene-5-carboxylic acid ethyl ester::11a-Ethyl-2,3,4,5,11a,11b-hexahydro-1H-3a,9b-diaza-benzo[cd]fluoranthene-10-carboxylic acid 2-nitrooxy-ethyl ester(Vinpocetine)::CHEMBL71752::Vinpocetine::cid_443955 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 18840 ChEMBL 10.1016/j.bmcl.2019.05.052 10.7270/Q2VX0M21 31859156 Pan, BW; Shi, Y; Li, WC; Wang, Q; Pan, M; Wu, Q; Fu, HZ Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50059033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50059033&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search T7F 443955 103954935 CHEMBL71752 5285 ZINC19796031 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51328800 CC[C@@]12CCCN3CCc4c([C@H]13)n(C(COC(=S)Nc1ccc(C)cc1)=C2)c1ccccc41 InChI=1S/C28H31N3OS/c1-3-28-14-6-15-30-16-13-23-22-7-4-5-8-24(22)31(25(23)26(28)30)21(17-28)18-32-27(33)29-20-11-9-19(2)10-12-20/h4-5,7-12,17,26H,3,6,13-16,18H2,1-2H3,(H,29,33)/t26-,28+/m1/s1 UFGKTUSMOVJXPS-IAPPQJPRSA-N 50537807 CHEMBL4649694 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 42270 ChEMBL 10.1016/j.bmcl.2019.05.052 10.7270/Q2VX0M21 31859156 Pan, BW; Shi, Y; Li, WC; Wang, Q; Pan, M; Wu, Q; Fu, HZ Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537807&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 156022232 442139370 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51328801 CC[C@@]12CCCN3CCc4c([C@H]13)n(C(COC(=S)NC1CCCCC1)=C2)c1ccccc41 InChI=1S/C27H35N3OS/c1-2-27-14-8-15-29-16-13-22-21-11-6-7-12-23(21)30(24(22)25(27)29)20(17-27)18-31-26(32)28-19-9-4-3-5-10-19/h6-7,11-12,17,19,25H,2-5,8-10,13-16,18H2,1H3,(H,28,32)/t25-,27+/m1/s1 NOTHFSPZIZCNBI-VPUSJEBWSA-N 50537770 CHEMBL4642086 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 5.1 ChEMBL 10.1016/j.bmcl.2019.05.052 10.7270/Q2VX0M21 31859156 Pan, BW; Shi, Y; Li, WC; Wang, Q; Pan, M; Wu, Q; Fu, HZ Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537770 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537770&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 156016212 442139333 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51328802 CC[C@@]12CCCN3CCc4c([C@H]13)n(C(COC(=S)Nc1ccc(F)cc1)=C2)c1ccccc41 InChI=1S/C27H28FN3OS/c1-2-27-13-5-14-30-15-12-22-21-6-3-4-7-23(21)31(24(22)25(27)30)20(16-27)17-32-26(33)29-19-10-8-18(28)9-11-19/h3-4,6-11,16,25H,2,5,12-15,17H2,1H3,(H,29,33)/t25-,27+/m1/s1 WJOSNRVWQAFNHU-VPUSJEBWSA-N 50537772 CHEMBL4633023 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 16 ChEMBL 10.1016/j.bmcl.2019.05.052 10.7270/Q2VX0M21 31859156 Pan, BW; Shi, Y; Li, WC; Wang, Q; Pan, M; Wu, Q; Fu, HZ Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537772&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 156010474 442139335 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51328803 CC[C@@]12CCCN3CCc4c([C@H]13)n(C(COC(=S)Nc1cccc(F)c1)=C2)c1ccccc41 InChI=1S/C27H28FN3OS/c1-2-27-12-6-13-30-14-11-22-21-9-3-4-10-23(21)31(24(22)25(27)30)20(16-27)17-32-26(33)29-19-8-5-7-18(28)15-19/h3-5,7-10,15-16,25H,2,6,11-14,17H2,1H3,(H,29,33)/t25-,27+/m1/s1 GVCRMZAQTVDYHO-VPUSJEBWSA-N 50537785 CHEMBL4645801 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 7.9 ChEMBL 10.1016/j.bmcl.2019.05.052 10.7270/Q2VX0M21 31859156 Pan, BW; Shi, Y; Li, WC; Wang, Q; Pan, M; Wu, Q; Fu, HZ Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537785 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537785&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 156019416 442139348 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51328804 CC[C@@]12CCCN3CCc4c([C@H]13)n(C(CO\C(SC)=N\c1ccc(C)cc1)=C2)c1ccccc41 InChI=1S/C29H33N3OS/c1-4-29-15-7-16-31-17-14-24-23-8-5-6-9-25(23)32(26(24)27(29)31)22(18-29)19-33-28(34-3)30-21-12-10-20(2)11-13-21/h5-6,8-13,18,27H,4,7,14-17,19H2,1-3H3/b30-28-/t27-,29+/m1/s1 ZYRKUVFTSPIBBP-LPMJPCMRSA-N 50537792 CHEMBL4638576 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 16 ChEMBL 10.1016/j.bmcl.2019.05.052 10.7270/Q2VX0M21 31859156 Pan, BW; Shi, Y; Li, WC; Wang, Q; Pan, M; Wu, Q; Fu, HZ Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537792&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 156011745 442139355 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51328805 CC[C@@]12CCCN3CCc4c([C@H]13)n(C(COC(=S)N(C(=O)N1CCOCC1)c1ccccc1)=C2)c1ccccc41 InChI=1S/C32H36N4O3S/c1-2-32-14-8-15-33-16-13-26-25-11-6-7-12-27(25)35(28(26)29(32)33)24(21-32)22-39-31(40)36(23-9-4-3-5-10-23)30(37)34-17-19-38-20-18-34/h3-7,9-12,21,29H,2,8,13-20,22H2,1H3/t29-,32+/m1/s1 WLKAAHFCWMYOLP-PPTMTGTBSA-N 50537798 CHEMBL4637690 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 6.8 ChEMBL 10.1016/j.bmcl.2019.05.052 10.7270/Q2VX0M21 31859156 Pan, BW; Shi, Y; Li, WC; Wang, Q; Pan, M; Wu, Q; Fu, HZ Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537798&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 156012779 442139361 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51328806 CC[C@@]12CCCN3CCc4c([C@H]13)n(C(CNC(=S)NC(=O)c1ccc(OC)cc1)=C2)c1ccccc41 InChI=1S/C29H32N4O2S/c1-3-29-14-6-15-32-16-13-23-22-7-4-5-8-24(22)33(25(23)26(29)32)20(17-29)18-30-28(36)31-27(34)19-9-11-21(35-2)12-10-19/h4-5,7-12,17,26H,3,6,13-16,18H2,1-2H3,(H2,30,31,34,36)/t26-,29+/m1/s1 UGUZCEQAYOPFLN-UHSQPCAPSA-N 50537803 CHEMBL4633227 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 68 ChEMBL 10.1016/j.bmcl.2019.05.052 10.7270/Q2VX0M21 31859156 Pan, BW; Shi, Y; Li, WC; Wang, Q; Pan, M; Wu, Q; Fu, HZ Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537803 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537803&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 156009493 442139366 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51328807 CC[C@@]12CCCN3CCc4c([C@H]13)n(C(CNC(=S)Nc1ccc(Cl)cc1)=C2)c1ccccc41 InChI=1S/C27H29ClN4S/c1-2-27-13-5-14-31-15-12-22-21-6-3-4-7-23(21)32(24(22)25(27)31)20(16-27)17-29-26(33)30-19-10-8-18(28)9-11-19/h3-4,6-11,16,25H,2,5,12-15,17H2,1H3,(H2,29,30,33)/t25-,27+/m1/s1 ZUBAGCFQKUERTB-VPUSJEBWSA-N 50537806 CHEMBL4643091 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 46 ChEMBL 10.1016/j.bmcl.2019.05.052 10.7270/Q2VX0M21 31859156 Pan, BW; Shi, Y; Li, WC; Wang, Q; Pan, M; Wu, Q; Fu, HZ Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537806 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537806&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 156016247 442139369 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51328808 CCOC(=O)C1=C[C@]2(CC)CCCN3CCc4c([C@H]23)n1c1ccccc41 InChI=1S/C22H26N2O2/c1-3-22-11-7-12-23-13-10-16-15-8-5-6-9-17(15)24(19(16)20(22)23)18(14-22)21(25)26-4-2/h5-6,8-9,14,20H,3-4,7,10-13H2,1-2H3/t20-,22+/m1/s1 DDNCQMVWWZOMLN-IRLDBZIGSA-N 50059033 (11aS,11bS)-11a-Ethyl-2,3,4,5,11a,11b-hexahydro-1H-3a,9b-diaza-benzo[cd]fluoranthene-10-carboxylic acid ethyl ester::(3S,16S)-apovincaminic acid ethylester::(3aS,11bS)-3a-ethyl-1,2,3,3a,10,11b-hexahydro-11H-5a,11a-diaza-benzo[cd]fluoranthene-5-carboxylic acid ethyl ester::11a-Ethyl-2,3,4,5,11a,11b-hexahydro-1H-3a,9b-diaza-benzo[cd]fluoranthene-10-carboxylic acid 2-nitrooxy-ethyl ester(Vinpocetine)::CHEMBL71752::Vinpocetine::cid_443955 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 14 ChEMBL 10.1016/j.bmcl.2019.05.052 10.7270/Q2VX0M21 31859156 Pan, BW; Shi, Y; Li, WC; Wang, Q; Pan, M; Wu, Q; Fu, HZ Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50059033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50059033&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search T7F 443955 103954935 CHEMBL71752 5285 ZINC19796031 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983290 CCCc1ncc2n1ccn(Cc1cccc(F)c1)c2=O InChI=1S/C16H16FN3O/c1-2-4-15-18-10-14-16(21)19(7-8-20(14)15)11-12-5-3-6-13(17)9-12/h3,5-10H,2,4,11H2,1H3 MUGBFEOWKYVLQV-UHFFFAOYSA-N 474108 7-(3-Fluorobenzyl)-3- propylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 1::US10912773, Example 1::US11472810, Example 1 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 801 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474108&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652260 442074307 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983293 Fc1cccc(Cn2c(Cc3ccccc3)cn3c(ncc3c2=O)C2CCOCC2)c1 InChI=1S/C25H24FN3O2/c26-21-8-4-7-19(13-21)16-28-22(14-18-5-2-1-3-6-18)17-29-23(25(28)30)15-27-24(29)20-9-11-31-12-10-20/h1-8,13,15,17,20H,9-12,14,16H2 NTXQTICQWIKNOO-UHFFFAOYSA-N 474109 6-Benzyl-7-(3-fluorobenzyl)-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 2::US10912773, Example 2::US11472810, Example 2 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 51.0 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474109&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652351 442074308 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983296 O=c1n(CC2CCCCC2)c(Cc2ccccc2)cn2c(ncc12)C1CCOCC1 InChI=1S/C25H31N3O2/c29-25-23-16-26-24(21-11-13-30-14-12-21)28(23)18-22(15-19-7-3-1-4-8-19)27(25)17-20-9-5-2-6-10-20/h1,3-4,7-8,16,18,20-21H,2,5-6,9-15,17H2 DDTRHXHSHXSEDF-UHFFFAOYSA-N 474110 6-Benzyl-7-(cyclohexylmethyl)-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 3::US10912773, Example 3::US11472810, Example 3 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.00 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474110&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652211 442074309 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983299 Cc1cn2c(ncc2c(=O)n1CC1CCCCC1)C1CCOCC1 InChI=1S/C19H27N3O2/c1-14-12-22-17(11-20-18(22)16-7-9-24-10-8-16)19(23)21(14)13-15-5-3-2-4-6-15/h11-12,15-16H,2-10,13H2,1H3 XQZACXVVNPRUIZ-UHFFFAOYSA-N 474111 7-(Cyclohexylmethyl)-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 4::US10912773, Example 4::US11472810, Example 4 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 11.0 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474111&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652213 442074310 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983302 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)C1CCOCC1 InChI=1S/C19H20FN3O2/c1-13-11-23-17(10-21-18(23)15-5-7-25-8-6-15)19(24)22(13)12-14-3-2-4-16(20)9-14/h2-4,9-11,15H,5-8,12H2,1H3 DOTFZTSFGIKARD-UHFFFAOYSA-N 474112 7-(3-Fluorobenzyl)-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 5::US10912773, Example 5::US11472810, Example 5 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 108 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474112&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652328 442074311 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983307 O=c1n(CC2CCCCC2)ccn2c(ncc12)C1CC1 InChI=1S/C16H21N3O/c20-16-14-10-17-15(13-6-7-13)19(14)9-8-18(16)11-12-4-2-1-3-5-12/h8-10,12-13H,1-7,11H2 MVICHLUMJUWVOO-UHFFFAOYSA-N 474115 7-(Cyclohexylmethyl)-3- cyclopropylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 8::US10912773, Example 8::US11472810, Example 8 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 252 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474115&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652314 442074314 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983312 O=c1n(CC2CCCCC2)ccn2c(ncc12)C1CCOCC1 InChI=1S/C18H25N3O2/c22-18-16-12-19-17(15-6-10-23-11-7-15)21(16)9-8-20(18)13-14-4-2-1-3-5-14/h8-9,12,14-15H,1-7,10-11,13H2 XXIPRLNKXMMFIK-UHFFFAOYSA-N 474118 7-(Cyclohexylmethyl)-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 11::US10912773, Example 11::US11472810, Example 11 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 113 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474118&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652369 442074317 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983315 O=c1n(CC2CCCCCC2)ccn2c(ncc12)C1CCOCC1 InChI=1S/C19H27N3O2/c23-19-17-13-20-18(16-7-11-24-12-8-16)22(17)10-9-21(19)14-15-5-3-1-2-4-6-15/h9-10,13,15-16H,1-8,11-12,14H2 SGRJQQJTJHBFTK-UHFFFAOYSA-N 474119 7-(Cycloheptylmethyl)-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 12::US10912773, Example 12::US11472810, Example 12 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 30.0 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474119&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652262 442074318 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983318 O=c1n(CC2CCCCCC2)ccn2c(ncc12)C1CC1 InChI=1S/C17H23N3O/c21-17-15-11-18-16(14-7-8-14)20(15)10-9-19(17)12-13-5-3-1-2-4-6-13/h9-11,13-14H,1-8,12H2 YIBKFYWXALCNMI-UHFFFAOYSA-N 474120 7-(Cycloheptylmethyl)-3- cyclopropylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 13::US10912773, Example 13::US11472810, Example 13 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 87.0 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474120&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652224 442074319 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983321 Cc1cn2c(ncc2c(=O)n1Cc1ccc(Cl)cc1)C1CCOCC1 InChI=1S/C19H20ClN3O2/c1-13-11-23-17(10-21-18(23)15-6-8-25-9-7-15)19(24)22(13)12-14-2-4-16(20)5-3-14/h2-5,10-11,15H,6-9,12H2,1H3 YSJUCDCNAYRULZ-UHFFFAOYSA-N 474121 7-(4-Chlorobenzyl)-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 14::US10912773, Example 14::US11472810, Example 14 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 18.0 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474121&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652230 442074320 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983324 Fc1cccc(Cn2c(Br)cn3c(ncc3c2=O)C2CCOCC2)c1 InChI=1S/C18H17BrFN3O2/c19-16-11-22-15(9-21-17(22)13-4-6-25-7-5-13)18(24)23(16)10-12-2-1-3-14(20)8-12/h1-3,8-9,11,13H,4-7,10H2 JVYBBFBHTBCHNY-UHFFFAOYSA-N 474122 6-Bromo-7-(3-fluorobenzyl)-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 15::US10912773, Example 15::US11472810, Example 15 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 58.0 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474122&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652389 442074321 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983327 Cc1cn2c(ncc2c(=O)n1Cc1ccccc1)C1CCOCC1 InChI=1S/C19H21N3O2/c1-14-12-22-17(11-20-18(22)16-7-9-24-10-8-16)19(23)21(14)13-15-5-3-2-4-6-15/h2-6,11-12,16H,7-10,13H2,1H3 JBXKPHLWRUHDIB-UHFFFAOYSA-N 474123 7-Benzyl-6-methyl-3-(tetrahydro- 2H-pyran-4-yl)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 16::US10912773, Example 16::US11472810, Example 16 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 85.0 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474123&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652416 442074322 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983330 Cc1cn2c(ncc2c(=O)n1Cc1ccccc1F)C1CCOCC1 InChI=1S/C19H20FN3O2/c1-13-11-23-17(10-21-18(23)14-6-8-25-9-7-14)19(24)22(13)12-15-4-2-3-5-16(15)20/h2-5,10-11,14H,6-9,12H2,1H3 SGDZBPUOHUWTHZ-UHFFFAOYSA-N 474124 7-(2-Fluorobenzyl)-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 17::US10912773, Example 17::US11472810, Example 17 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 42.0 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474124&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652218 442074323 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983333 Cc1cn2c(ncc2c(=O)n1Cc1cccc(Cl)c1)C1CCOCC1 InChI=1S/C19H20ClN3O2/c1-13-11-23-17(10-21-18(23)15-5-7-25-8-6-15)19(24)22(13)12-14-3-2-4-16(20)9-14/h2-4,9-11,15H,5-8,12H2,1H3 FRYCFLNTERXYHU-UHFFFAOYSA-N 474125 7-(3-Chlorobenzyl)-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 18::US10912773, Example 18::US11472810, Example 18 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 57.0 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474125&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652215 442074324 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983336 Cc1cn2c(ncc2c(=O)n1Cc1ccccc1Cl)C1CCOCC1 InChI=1S/C19H20ClN3O2/c1-13-11-23-17(10-21-18(23)14-6-8-25-9-7-14)19(24)22(13)12-15-4-2-3-5-16(15)20/h2-5,10-11,14H,6-9,12H2,1H3 RNBCFPQVHXWYQR-UHFFFAOYSA-N 474126 7-(2-Chlorobenzyl)-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 19::US10912773, Example 19::US11472810, Example 19 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 46.0 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474126&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652210 442074325 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983339 COc1cccc(Cn2c(C)cn3c(ncc3c2=O)C2CCOCC2)c1 InChI=1S/C20H23N3O3/c1-14-12-23-18(11-21-19(23)16-6-8-26-9-7-16)20(24)22(14)13-15-4-3-5-17(10-15)25-2/h3-5,10-12,16H,6-9,13H2,1-2H3 OYBSUAILVMFPHS-UHFFFAOYSA-N 474127 7-(3-Methoxybenzyl)-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 20::US10912773, Example 20::US11472810, Example 20 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 416 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474127&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652387 442074326 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983342 Cc1ccccc1Cn1c(C)cn2c(ncc2c1=O)C1CCOCC1 InChI=1S/C20H23N3O2/c1-14-5-3-4-6-17(14)13-22-15(2)12-23-18(20(22)24)11-21-19(23)16-7-9-25-10-8-16/h3-6,11-12,16H,7-10,13H2,1-2H3 ICFZMMURQAUHKS-UHFFFAOYSA-N 474128 6-Methyl-7-(2-methylbenzyl)-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 21::US10912773, Example 21::US11472810, Example 21 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 242 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474128&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652209 442074327 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983345 Cc1ccc(Cn2c(C)cn3c(ncc3c2=O)C2CCOCC2)cc1 InChI=1S/C20H23N3O2/c1-14-3-5-16(6-4-14)13-22-15(2)12-23-18(20(22)24)11-21-19(23)17-7-9-25-10-8-17/h3-6,11-12,17H,7-10,13H2,1-2H3 NJLBYLKOKZGPPW-UHFFFAOYSA-N 474129 6-Methyl-7-(4-methylbenzyl)-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 22::US10912773, Example 22::US11472810, Example 22 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 75.0 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474129&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652392 442074328 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983348 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C2CCOCC2)cc1 InChI=1S/C20H23N3O3/c1-14-12-23-18(11-21-19(23)16-7-9-26-10-8-16)20(24)22(14)13-15-3-5-17(25-2)6-4-15/h3-6,11-12,16H,7-10,13H2,1-2H3 PUKNFFAMUWZTGI-UHFFFAOYSA-N 474130 7-(4-Methoxybenzyl)-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 23::US10912773, Example 23::US11472810, Example 23 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 14.0 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474130 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474130&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652249 442074329 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983351 Cc1cn2c(ncc2c(=O)n1Cc1ccc(F)cc1)C1CCOCC1 InChI=1S/C19H20FN3O2/c1-13-11-23-17(10-21-18(23)15-6-8-25-9-7-15)19(24)22(13)12-14-2-4-16(20)5-3-14/h2-5,10-11,15H,6-9,12H2,1H3 HTAKTLWSUKQRRS-UHFFFAOYSA-N 474131 7-(4-Fluorobenzyl)-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 24::US10912773, Example 24::US11472810, Example 24 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 38.0 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474131&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652282 442074330 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983354 Cc1cccc(Cn2c(C)cn3c(ncc3c2=O)C2CCOCC2)c1 InChI=1S/C20H23N3O2/c1-14-4-3-5-16(10-14)13-22-15(2)12-23-18(20(22)24)11-21-19(23)17-6-8-25-9-7-17/h3-5,10-12,17H,6-9,13H2,1-2H3 FCLGCXKNDLJHGE-UHFFFAOYSA-N 474132 6-Methyl-7-(3-methylbenzyl)-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 25::US10912773, Example 25::US11472810, Example 25 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 63.0 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474132&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652311 442074331 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983357 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)C1(C)CCOCC1 InChI=1S/C20H22FN3O2/c1-14-12-24-17(11-22-19(24)20(2)6-8-26-9-7-20)18(25)23(14)13-15-4-3-5-16(21)10-15/h3-5,10-12H,6-9,13H2,1-2H3 MVBCAJXPQPBVSA-UHFFFAOYSA-N 474133 7-(3-fluorobenzyl)-6-methyl-3-(4- methyltetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 26::US10912773, Example 26::US11472810, Example 26 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 234 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474133&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652437 442074332 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983360 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)C1(CCOCC1)C#N InChI=1S/C20H19FN4O2/c1-14-11-25-17(10-23-19(25)20(13-22)5-7-27-8-6-20)18(26)24(14)12-15-3-2-4-16(21)9-15/h2-4,9-11H,5-8,12H2,1H3 USXLZPZGBIYQLQ-UHFFFAOYSA-N 474134 4-(7-(3-fluorobenzyl)-6-methyl-8- oxo-7,8-dihydroimidazo[1,5- a]pyrazin-3-yl)tetrahydro-2H- pyran-4-carbonitrile::US10858362, Example 27::US10912773, Example 27::US11472810, Example 27 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 603 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474134&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652325 442074333 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983363 COC1(CCOCC1)c1ncc2n1cc(C)n(Cc1cccc(F)c1)c2=O InChI=1S/C20H22FN3O3/c1-14-12-24-17(11-22-19(24)20(26-2)6-8-27-9-7-20)18(25)23(14)13-15-4-3-5-16(21)10-15/h3-5,10-12H,6-9,13H2,1-2H3 ZCVGFCXGAGKYHH-UHFFFAOYSA-N 474135 7-(3-fluorobenzyl)-3-(4- methoxytetrahydro-2H-pyran-4- yl)-6-methylimidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 28::US10912773, Example 28::US11472810, Example 28 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 663 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474135&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652291 442074334 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983366 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)C1(F)CCOCC1 InChI=1S/C19H19F2N3O2/c1-13-11-24-16(10-22-18(24)19(21)5-7-26-8-6-19)17(25)23(13)12-14-3-2-4-15(20)9-14/h2-4,9-11H,5-8,12H2,1H3 RQWUWJPTWQLWON-UHFFFAOYSA-N 474136 7-(3-fluorobenzyl)-3-(4- fluorotetrahydro-2H-pyran-4-yl)- 6-methylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 29::US10912773, Example 29::US11472810, Example 29 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 493 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474136&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652263 442074335 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983372 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)[C@@H]1CCOC1 InChI=1S/C18H18FN3O2/c1-12-9-22-16(8-20-17(22)14-5-6-24-11-14)18(23)21(12)10-13-3-2-4-15(19)7-13/h2-4,7-9,14H,5-6,10-11H2,1H3/t14-/m1/s1 LEYPTBGWIKQYRW-CQSZACIVSA-N 474139 7-(3-fluorobenzyl)-6-methyl-3- (tetrahydrofuran-3-yl)imidazo[1,5- a]pyrazin-8(7H)-one, stereoisomer 1::US10858362, Example 31, isomer 1::US10905688, Example 31, isomer 1::US11472810, Example 31, isomer 1 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 337 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474139&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652497 442074338 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983375 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)[C@H]1CCOC1 InChI=1S/C18H18FN3O2/c1-12-9-22-16(8-20-17(22)14-5-6-24-11-14)18(23)21(12)10-13-3-2-4-15(19)7-13/h2-4,7-9,14H,5-6,10-11H2,1H3/t14-/m0/s1 LEYPTBGWIKQYRW-AWEZNQCLSA-N 474140 7-(3-fluorobenzyl)-6-methyl-3- (tetrahydrofuran-3-yl)imidazo[1,5- a]pyrazin-8(7H)-one, stereoisomer 2::US10858362, Example 31, isomer 2::US10912773, Example 31-isomer-2::US11472810, Example 31, isomer 2 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 347 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474140 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474140&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652532 442074339 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983378 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)[C@]1(C)CCOC1 InChI=1S/C19H20FN3O2/c1-13-10-23-16(9-21-18(23)19(2)6-7-25-12-19)17(24)22(13)11-14-4-3-5-15(20)8-14/h3-5,8-10H,6-7,11-12H2,1-2H3/t19-/m1/s1 AQLHITNAEZNQJK-LJQANCHMSA-N 474141 7-(3-fluorobenzyl)-6-methyl-3-(3- methyltetrahydrofuran-3- yl)imidazo[1,5-a]pyrazin-8(7H)- one, stereoisomer 1::US10858362, Example 32, isomer 1::US10912773, Example 32-isomer-1::US11472810, Example 32, isomer 2 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 257 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474141 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474141&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652541 442074340 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983381 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)[C@@]1(C)CCOC1 InChI=1S/C19H20FN3O2/c1-13-10-23-16(9-21-18(23)19(2)6-7-25-12-19)17(24)22(13)11-14-4-3-5-15(20)8-14/h3-5,8-10H,6-7,11-12H2,1-2H3/t19-/m0/s1 AQLHITNAEZNQJK-IBGZPJMESA-N 474142 7-(3-fluorobenzyl)-6-methyl-3-(3- methyltetrahydrofuran-3- yl)imidazo[1,5-a]pyrazin-8(7H)- one, stereoisomer 2::US10858362, Example 32, isomer 2::US10912773, Example 32-isomer-2::US11472810, Example 32, isomer 1 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 401 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474142&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652347 442074341 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983384 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)C1(C)CC1 InChI=1S/C18H18FN3O/c1-12-10-22-15(9-20-17(22)18(2)6-7-18)16(23)21(12)11-13-4-3-5-14(19)8-13/h3-5,8-10H,6-7,11H2,1-2H3 VCCNMXVKDHUXGT-UHFFFAOYSA-N 474143 7-(3-fluorobenzyl)-6-methyl-3-(1- methylcyclopropyl)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 33::US10912773, Example 33::US11472810, Example 33 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 94.0 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474143 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474143&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652394 442074342 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983387 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)C1CC1(F)F InChI=1S/C17H14F3N3O/c1-10-8-23-14(7-21-15(23)13-6-17(13,19)20)16(24)22(10)9-11-3-2-4-12(18)5-11/h2-5,7-8,13H,6,9H2,1H3 GEKRVCRUZXROSZ-UHFFFAOYSA-N 474144 3-(2,2-difluorocyclopropyl)-7-(3- fluorobenzyl)-6- methylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 34::US10905688, Example 34::US11472810, Example 34 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 331 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474144&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652478 442074343 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983390 C[C@H]1C[C@H]1c1ncc2n1cc(C)n(Cc1cccc(F)c1)c2=O InChI=1S/C18H18FN3O/c1-11-6-15(11)17-20-8-16-18(23)21(12(2)9-22(16)17)10-13-4-3-5-14(19)7-13/h3-5,7-9,11,15H,6,10H2,1-2H3/t11-,15+/m0/s1 NSFYZWGFIIQKQP-XHDPSFHLSA-N 474145 7-(3-fluorobenzyl)-6-methyl-3-(2- methylcyclopropyl)imidazo[1,5- a]pyrazin-8(7H)-one, stereoisomer 1::US10858362, Example 35, isomer 1::US10912773, Example 35-isomer-1::US11472810, Example 35, isomer 1 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 193 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474145&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652399 442074344 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983393 C[C@@H]1C[C@H]1c1ncc2n1cc(C)n(Cc1cccc(F)c1)c2=O InChI=1S/C18H18FN3O/c1-11-6-15(11)17-20-8-16-18(23)21(12(2)9-22(16)17)10-13-4-3-5-14(19)7-13/h3-5,7-9,11,15H,6,10H2,1-2H3/t11-,15-/m1/s1 NSFYZWGFIIQKQP-IAQYHMDHSA-N 474146 7-(3-fluorobenzyl)-6-methyl-3-(2- methylcyclopropyl)imidazo[1,5- a]pyrazin-8(7H)-one, stereoisomer 2::US10858362, Example 35, isomer 2::US10912773, Example 35-isomer-3::US11472810, Example 35, isomer 2 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 364 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474146&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652492 442074345 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983396 C[C@H]1C[C@@H]1c1ncc2n1cc(C)n(Cc1cccc(F)c1)c2=O InChI=1S/C18H18FN3O/c1-11-6-15(11)17-20-8-16-18(23)21(12(2)9-22(16)17)10-13-4-3-5-14(19)7-13/h3-5,7-9,11,15H,6,10H2,1-2H3/t11-,15-/m0/s1 NSFYZWGFIIQKQP-NHYWBVRUSA-N 474147 7-(3-fluorobenzyl)-6-methyl-3-(2- methylcyclopropyl)imidazo[1,5- a]pyrazin-8(7H)-one, stereoisomer 3::US10858362, Example 35, isomer 3::US10905688, Example 35, isomer 3::US11472810, Example 35, isomer 3 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 82.0 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474147&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652536 442074346 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983399 C[C@@H]1C[C@@H]1c1ncc2n1cc(C)n(Cc1cccc(F)c1)c2=O InChI=1S/C18H18FN3O/c1-11-6-15(11)17-20-8-16-18(23)21(12(2)9-22(16)17)10-13-4-3-5-14(19)7-13/h3-5,7-9,11,15H,6,10H2,1-2H3/t11-,15+/m1/s1 NSFYZWGFIIQKQP-ABAIWWIYSA-N 474148 7-(3-fluorobenzyl)-6-methyl-3-(2- methylcyclopropyl)imidazo[1,5- a]pyrazin-8(7H)-one, stereoisomer 4::US10858362, Example 35, isomer 4::US10912773, Example 35-isomer-4::US11472810, Example 35, isomer 4 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 43.0 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474148&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652401 442074347 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983402 C[C@H]1OCC[C@H]1c1ncc2n1cc(C)n(Cc1cccc(F)c1)c2=O InChI=1S/C19H20FN3O2/c1-12-10-23-17(9-21-18(23)16-6-7-25-13(16)2)19(24)22(12)11-14-4-3-5-15(20)8-14/h3-5,8-10,13,16H,6-7,11H2,1-2H3/t13-,16-/m1/s1 BZFPDTIGFMRZDI-CZUORRHYSA-N 474149 7-(3-fluorobenzyl)-6-methyl-3-(2- methyltetrahydrofuran-3- yl)imidazo[1,5-a]pyrazin-8(7H)- one, stereoisomer 1::US10858362, Example 36, isomer 1::US10912773, Example 36-isomer-1::US11472810, Example 36, isomer 1 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 152 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474149&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652377 442074348 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983405 C[C@H]1OCC[C@@H]1c1ncc2n1cc(C)n(Cc1cccc(F)c1)c2=O InChI=1S/C19H20FN3O2/c1-12-10-23-17(9-21-18(23)16-6-7-25-13(16)2)19(24)22(12)11-14-4-3-5-15(20)8-14/h3-5,8-10,13,16H,6-7,11H2,1-2H3/t13-,16+/m1/s1 BZFPDTIGFMRZDI-CJNGLKHVSA-N 474150 7-(3-fluorobenzyl)-6-methyl-3-(2- methyltetrahydrofuran-3- yl)imidazo[1,5-a]pyrazin-8(7H)- one, stereoisomer 2::US10858362, Example 36, isomer 2::US10912773, Example 36-isomer-2::US11472810, Example 36, isomer 3 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 282 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474150&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652487 442074349 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983408 C[C@@H]1OCC[C@H]1c1ncc2n1cc(C)n(Cc1cccc(F)c1)c2=O InChI=1S/C19H20FN3O2/c1-12-10-23-17(9-21-18(23)16-6-7-25-13(16)2)19(24)22(12)11-14-4-3-5-15(20)8-14/h3-5,8-10,13,16H,6-7,11H2,1-2H3/t13-,16+/m0/s1 BZFPDTIGFMRZDI-XJKSGUPXSA-N 474151 7-(3-fluorobenzyl)-6-methyl-3-(2- methyltetrahydrofuran-3- yl)imidazo[1,5-a]pyrazin-8(7H)- one, stereoisomer 3::US10858362, Example 36, isomer 3::US10912773, Example 36-isomer-3::US11472810, Example 36, isomer 2 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 77.0 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474151 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474151&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652488 442074350 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983411 C[C@@H]1OCC[C@@H]1c1ncc2n1cc(C)n(Cc1cccc(F)c1)c2=O InChI=1S/C19H20FN3O2/c1-12-10-23-17(9-21-18(23)16-6-7-25-13(16)2)19(24)22(12)11-14-4-3-5-15(20)8-14/h3-5,8-10,13,16H,6-7,11H2,1-2H3/t13-,16-/m0/s1 BZFPDTIGFMRZDI-BBRMVZONSA-N 474152 7-(3-fluorobenzyl)-6-methyl-3-(2- methyltetrahydrofuran-3- yl)imidazo[1,5-a]pyrazin-8(7H)- one, stereoisomer 4::US10858362, Example 36, isomer 4::US10912773, Example 36-isomer-4::US11472810, Example 36, isomer 4 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 51.0 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474152&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652474 442074351 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983413 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)C1C[C@@H]1F InChI=1S/C17H15F2N3O/c1-10-8-22-15(7-20-16(22)13-6-14(13)19)17(23)21(10)9-11-3-2-4-12(18)5-11/h2-5,7-8,13-14H,6,9H2,1H3/t13?,14-/m0/s1 MVVQNOPLTGEXNR-KZUDCZAMSA-N 474153 7-(3-fluorobenzyl)-3-(cis-2- fluorocyclopropyl)-6- methylimidazo[1,5-a]pyrazin- 8(7H)-one, stereoisomer 1::US10858362, Example 37, isomer 1::US10912773, Example 38-isomer-1 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1140 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474153&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122663819 442074352 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983416 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)[C@@H]1C[C@H]1F InChI=1S/C17H15F2N3O/c1-10-8-22-15(7-20-16(22)13-6-14(13)19)17(23)21(10)9-11-3-2-4-12(18)5-11/h2-5,7-8,13-14H,6,9H2,1H3/t13-,14-/m1/s1 MVVQNOPLTGEXNR-ZIAGYGMSSA-N 474154 7-(3-fluorobenzyl)-3-(cis-2- fluorocyclopropyl)-6- methylimidazo[1,5-a]pyrazin- 8(7H)-one, stereoisomer 2::US10858362, Example 37, isomer 2::US10905688, Example 38, isomer 1 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 149 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474154&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652341 442074353 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983419 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)[C@H]1C[C@@H]1F InChI=1S/C17H15F2N3O/c1-10-8-22-15(7-20-16(22)13-6-14(13)19)17(23)21(10)9-11-3-2-4-12(18)5-11/h2-5,7-8,13-14H,6,9H2,1H3/t13-,14-/m0/s1 MVVQNOPLTGEXNR-KBPBESRZSA-N 474155 7-(3-fluorobenzyl)-3-(trans-2- fluorocyclopropyl)-6- methylimidazo[1,5-a]pyrazin- 8(7H)-one, stereoisomer 1::US10858362, Example 38, isomer 1::US10905688, Example 37, isomer 2::US11472810, Example 37, isomer 2 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 582 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474155&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652432 442074354 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983422 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)[C@H]1C[C@H]1F InChI=1S/C17H15F2N3O/c1-10-8-22-15(7-20-16(22)13-6-14(13)19)17(23)21(10)9-11-3-2-4-12(18)5-11/h2-5,7-8,13-14H,6,9H2,1H3/t13-,14+/m0/s1 MVVQNOPLTGEXNR-UONOGXRCSA-N 474156 7-(3-fluorobenzyl)-3-(trans-2- fluorocyclopropyl)-6- methylimidazo[1,5-a]pyrazin- 8(7H)-one, stereoisomer 2::US10858362, Example 38, isomer 2::US10905688, Example 38, isomer 2::US11472810, Example 38, isomer 2 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 667 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474156&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652469 442074355 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983425 Cc1cn2c(ncc2c(=O)n1Cc1ccc(OC2CC2)cc1)C1CCOCC1 InChI=1S/C22H25N3O3/c1-15-13-25-20(12-23-21(25)17-8-10-27-11-9-17)22(26)24(15)14-16-2-4-18(5-3-16)28-19-6-7-19/h2-5,12-13,17,19H,6-11,14H2,1H3 RVWGYNGTLDYNPU-UHFFFAOYSA-N 474157 7-(4-cyclopropoxybenzyl)-6- methyl-3-(tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 39::US10912773, Example 39::US11472810, Example 39 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 413 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474157&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652459 442074356 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983428 Cc1cn2c(ncc2c(=O)n1Cc1ccc(OC(F)F)cc1)C1CCOCC1 InChI=1S/C20H21F2N3O3/c1-13-11-25-17(10-23-18(25)15-6-8-27-9-7-15)19(26)24(13)12-14-2-4-16(5-3-14)28-20(21)22/h2-5,10-11,15,20H,6-9,12H2,1H3 QPWYRFGVZKZRGE-UHFFFAOYSA-N 474158 7-(4-(difluoromethoxy)benzyl)-6- methyl-3-(tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 40::US10912773, Example 40::US11472810, Example 40 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 73.0 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474158&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652417 442074357 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983431 Cc1cn2c(ncc2c(=O)n1Cc1ccc(OC(F)(F)F)cc1)C1CCOCC1 InChI=1S/C20H20F3N3O3/c1-13-11-26-17(10-24-18(26)15-6-8-28-9-7-15)19(27)25(13)12-14-2-4-16(5-3-14)29-20(21,22)23/h2-5,10-11,15H,6-9,12H2,1H3 UNRQWEFTRALILW-UHFFFAOYSA-N 474159 6-methyl-3-(tetrahydro-2H-pyran- 4-yl)-7-(4- (trifluoromethoxy)benzyl)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 41::US10912773, Example 41::US11472810, Example 41 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 27.0 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474159&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652254 442074358 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983435 CCc1cn2c(ncc2c(=O)n1Cc1ccccc1)C1CCOCC1 InChI=1S/C20H23N3O2/c1-2-17-14-23-18(12-21-19(23)16-8-10-25-11-9-16)20(24)22(17)13-15-6-4-3-5-7-15/h3-7,12,14,16H,2,8-11,13H2,1H3 LEQLMZLBAGAUDL-UHFFFAOYSA-N 474161 7-benzyl-6-ethyl-3-(tetrahydro- 2H-pyran-4-yl)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 43::US10912773, Example 43::US11472810, Example 43 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 105 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474161&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652424 442074360 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983438 CCc1cn2c(ncc2c(=O)n1Cc1ccc(OC)cc1)C1CCOCC1 InChI=1S/C21H25N3O3/c1-3-17-14-24-19(12-22-20(24)16-8-10-27-11-9-16)21(25)23(17)13-15-4-6-18(26-2)7-5-15/h4-7,12,14,16H,3,8-11,13H2,1-2H3 IHHHPGCUSMYQHX-UHFFFAOYSA-N 474162 6-ethyl-7-(4-methoxybenzyl)-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 44::US10912773, Example 44::US11472810, Example 44 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 40.0 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474162&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652232 442074361 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983441 Cc1cn2c(ncc2c(=O)n1Cc1cccc(c1)C#N)C1CCOCC1 InChI=1S/C20H20N4O2/c1-14-12-24-18(11-22-19(24)17-5-7-26-8-6-17)20(25)23(14)13-16-4-2-3-15(9-16)10-21/h2-4,9,11-12,17H,5-8,13H2,1H3 HBKUUJGKQVTMIE-UHFFFAOYSA-N 474163 3-((6-methyl-8-oxo-3-(tetrahydro- 2H-pyran-4-yl)imidazo[1,5- a]pyrazin-7(8H)- yl)methyl)benzonitrile::US10858362, Example 45::US10912773, Example 45::US11472810, Example 45 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 64.0 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474163&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652242 442074362 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983443 Cc1cn2c(ncc2c(=O)n1Cc1ccc(cc1)C#N)C1CCOCC1 InChI=1S/C20H20N4O2/c1-14-12-24-18(11-22-19(24)17-6-8-26-9-7-17)20(25)23(14)13-16-4-2-15(10-21)3-5-16/h2-5,11-12,17H,6-9,13H2,1H3 LQAZSSIUEDYCBP-UHFFFAOYSA-N 474164 4-((6-methyl-8-oxo-3-(tetrahydro- 2H-pyran-4-yl)imidazo[1,5- a]pyrazin-7(8H)- yl)methyl)benzonitrile::US10858362, Example 46::US10912773, Example 46::US11472810, Example 46 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 809 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474164&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652248 442074363 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983445 CCc1ccccc1Cn1c(C)cn2c(ncc2c1=O)C1CCOCC1 InChI=1S/C21H25N3O2/c1-3-16-6-4-5-7-18(16)14-23-15(2)13-24-19(21(23)25)12-22-20(24)17-8-10-26-11-9-17/h4-7,12-13,17H,3,8-11,14H2,1-2H3 HLXDXKMIVTXPEU-UHFFFAOYSA-N 474166 7-(2-ethylbenzyl)-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 49::US10912773, Example 49::US11472810, Example 49 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 44.0 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474166&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652447 442074365 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983447 Cc1cn2c(ncc2c(=O)n1Cc1ccc2OCOc2c1)C1CCOCC1 InChI=1S/C20H21N3O4/c1-13-10-23-16(9-21-19(23)15-4-6-25-7-5-15)20(24)22(13)11-14-2-3-17-18(8-14)27-12-26-17/h2-3,8-10,15H,4-7,11-12H2,1H3 ZABNCYCWYYVHOF-UHFFFAOYSA-N 474167 7-(benzo[d][1,3]dioxol-5- ylmethyl)-6-methyl-3-(tetrahydro- 2H-pyran-4-yl)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 50::US10912773, Example 50::US11472810, Example 50 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 50.0 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474167 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474167&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652367 442074366 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983450 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C2CCOCC2)cc1Cl InChI=1S/C20H22ClN3O3/c1-13-11-24-17(10-22-19(24)15-5-7-27-8-6-15)20(25)23(13)12-14-3-4-18(26-2)16(21)9-14/h3-4,9-11,15H,5-8,12H2,1-2H3 AKDKVOQBJMHADC-UHFFFAOYSA-N 474168 7-(3-chloro-4-methoxybenzyl)-6- methyl-3-(tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 51::US10912773, Example 51::US11472810, Example 51 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 199 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474168&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652468 442074367 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983454 Cc1cn2c(ncc2c(=O)n1Cc1ccc(O)cc1)C1CCOCC1 InChI=1S/C19H21N3O3/c1-13-11-22-17(10-20-18(22)15-6-8-25-9-7-15)19(24)21(13)12-14-2-4-16(23)5-3-14/h2-5,10-11,15,23H,6-9,12H2,1H3 HWZIGTUHYHCMIT-UHFFFAOYSA-N 474170 7-(4-hydroxybenzyl)-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 53::US10912773, Example 53::US11472810, Example 53 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 401 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474170&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652448 442074369 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983457 CCc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)C1CCOCC1 InChI=1S/C20H22FN3O2/c1-2-17-13-24-18(11-22-19(24)15-6-8-26-9-7-15)20(25)23(17)12-14-4-3-5-16(21)10-14/h3-5,10-11,13,15H,2,6-9,12H2,1H3 AFONMYZRPMFJAB-UHFFFAOYSA-N 474171 6-ethyl-7-(3-fluorobenzyl)-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 54::US10912773, Example 54::US11472810, Example 54 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 62.0 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474171&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652310 442074370 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983460 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)[C@@H]2CCO[C@@H]2C)cc1 InChI=1S/C20H23N3O3/c1-13-11-23-18(10-21-19(23)17-8-9-26-14(17)2)20(24)22(13)12-15-4-6-16(25-3)7-5-15/h4-7,10-11,14,17H,8-9,12H2,1-3H3/t14-,17-/m1/s1 PZHZVFDPQAUVKV-RHSMWYFYSA-N 474172 7-(4-methoxybenzyl)-6-methyl-3- (2-methyltetrahydrofuran-3- yl)imidazo[1,5-a]pyrazin-8(7H)- one, stereoisomer 1::US10858362, Example 55, isomer 1::US10912773, Example 55-isomer-1::US11472810, Example 55, isomer 1 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 20.0 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474172 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474172&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652364 442074371 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983463 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)[C@@H]2CCO[C@H]2C)cc1 InChI=1S/C20H23N3O3/c1-13-11-23-18(10-21-19(23)17-8-9-26-14(17)2)20(24)22(13)12-15-4-6-16(25-3)7-5-15/h4-7,10-11,14,17H,8-9,12H2,1-3H3/t14-,17+/m0/s1 PZHZVFDPQAUVKV-WMLDXEAASA-N 474173 7-(4-methoxybenzyl)-6-methyl-3- (2-methyltetrahydrofuran-3- yl)imidazo[1,5-a]pyrazin-8(7H)- one, stereoisomer 2::US10858362, Example 55, isomer 2::US10858362, Example 55, isomer 3::US10912773, Example 55-isomer-2::US11472810, Example 55, isomer 2 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 86.0 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474173&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652531 442074372 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983466 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)[C@@H]2CCO[C@H]2C)cc1 InChI=1S/C20H23N3O3/c1-13-11-23-18(10-21-19(23)17-8-9-26-14(17)2)20(24)22(13)12-15-4-6-16(25-3)7-5-15/h4-7,10-11,14,17H,8-9,12H2,1-3H3/t14-,17+/m0/s1 PZHZVFDPQAUVKV-WMLDXEAASA-N 474173 7-(4-methoxybenzyl)-6-methyl-3- (2-methyltetrahydrofuran-3- yl)imidazo[1,5-a]pyrazin-8(7H)- one, stereoisomer 2::US10858362, Example 55, isomer 2::US10858362, Example 55, isomer 3::US10912773, Example 55-isomer-2::US11472810, Example 55, isomer 2 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 13.0 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474173&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652531 442074372 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 983469 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)[C@H]2CCO[C@H]2C)cc1 InChI=1S/C20H23N3O3/c1-13-11-23-18(10-21-19(23)17-8-9-26-14(17)2)20(24)22(13)12-15-4-6-16(25-3)7-5-15/h4-7,10-11,14,17H,8-9,12H2,1-3H3/t14-,17-/m0/s1 PZHZVFDPQAUVKV-YOEHRIQHSA-N 474175 7-(4-methoxybenzyl)-6-methyl-3- (2-methyltetrahydrofuran-3- yl)imidazo[1,5-a]pyrazin-8(7H)- one, stereoisomer 4::US10858362, Example 55, isomer 4::US10905688, Example 55, isomer 4::US11472810, Example 55, isomer 4 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 137 US Patent 10.7270/Q2V127XG aid1805072 US10858362 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474175 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474175&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652443 442074373 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997335 CCCc1ncc2n1ccn(Cc1cccc(F)c1)c2=O InChI=1S/C16H16FN3O/c1-2-4-15-18-10-14-16(21)19(7-8-20(14)15)11-12-5-3-6-13(17)9-12/h3,5-10H,2,4,11H2,1H3 MUGBFEOWKYVLQV-UHFFFAOYSA-N 474108 7-(3-Fluorobenzyl)-3- propylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 1::US10912773, Example 1::US11472810, Example 1 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 801 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474108&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652260 442074307 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997338 Fc1cccc(Cn2c(Cc3ccccc3)cn3c(ncc3c2=O)C2CCOCC2)c1 InChI=1S/C25H24FN3O2/c26-21-8-4-7-19(13-21)16-28-22(14-18-5-2-1-3-6-18)17-29-23(25(28)30)15-27-24(29)20-9-11-31-12-10-20/h1-8,13,15,17,20H,9-12,14,16H2 NTXQTICQWIKNOO-UHFFFAOYSA-N 474109 6-Benzyl-7-(3-fluorobenzyl)-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 2::US10912773, Example 2::US11472810, Example 2 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 51.0 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474109&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652351 442074308 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997341 O=c1n(CC2CCCCC2)c(Cc2ccccc2)cn2c(ncc12)C1CCOCC1 InChI=1S/C25H31N3O2/c29-25-23-16-26-24(21-11-13-30-14-12-21)28(23)18-22(15-19-7-3-1-4-8-19)27(25)17-20-9-5-2-6-10-20/h1,3-4,7-8,16,18,20-21H,2,5-6,9-15,17H2 DDTRHXHSHXSEDF-UHFFFAOYSA-N 474110 6-Benzyl-7-(cyclohexylmethyl)-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 3::US10912773, Example 3::US11472810, Example 3 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.00 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474110&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652211 442074309 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997344 Cc1cn2c(ncc2c(=O)n1CC1CCCCC1)C1CCOCC1 InChI=1S/C19H27N3O2/c1-14-12-22-17(11-20-18(22)16-7-9-24-10-8-16)19(23)21(14)13-15-5-3-2-4-6-15/h11-12,15-16H,2-10,13H2,1H3 XQZACXVVNPRUIZ-UHFFFAOYSA-N 474111 7-(Cyclohexylmethyl)-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 4::US10912773, Example 4::US11472810, Example 4 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 11.0 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474111&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652213 442074310 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997347 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)C1CCOCC1 InChI=1S/C19H20FN3O2/c1-13-11-23-17(10-21-18(23)15-5-7-25-8-6-15)19(24)22(13)12-14-3-2-4-16(20)9-14/h2-4,9-11,15H,5-8,12H2,1H3 DOTFZTSFGIKARD-UHFFFAOYSA-N 474112 7-(3-Fluorobenzyl)-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 5::US10912773, Example 5::US11472810, Example 5 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 108 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474112&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652328 442074311 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997352 O=c1n(CC2CCCCC2)ccn2c(ncc12)C1CC1 InChI=1S/C16H21N3O/c20-16-14-10-17-15(13-6-7-13)19(14)9-8-18(16)11-12-4-2-1-3-5-12/h8-10,12-13H,1-7,11H2 MVICHLUMJUWVOO-UHFFFAOYSA-N 474115 7-(Cyclohexylmethyl)-3- cyclopropylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 8::US10912773, Example 8::US11472810, Example 8 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 252 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474115&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652314 442074314 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997357 O=c1n(CC2CCCCC2)ccn2c(ncc12)C1CCOCC1 InChI=1S/C18H25N3O2/c22-18-16-12-19-17(15-6-10-23-11-7-15)21(16)9-8-20(18)13-14-4-2-1-3-5-14/h8-9,12,14-15H,1-7,10-11,13H2 XXIPRLNKXMMFIK-UHFFFAOYSA-N 474118 7-(Cyclohexylmethyl)-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 11::US10912773, Example 11::US11472810, Example 11 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 113 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474118&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652369 442074317 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998968 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)N2CCCOCC2)cc1 InChI=1S/C20H24N4O3/c1-15-13-24-18(12-21-20(24)22-8-3-10-27-11-9-22)19(25)23(15)14-16-4-6-17(26-2)7-5-16/h4-7,12-13H,3,8-11,14H2,1-2H3 VCAGHSXTTDHBAV-UHFFFAOYSA-N 474217 7-(4-methoxybenzyl)-6-methyl-3- (1,4-oxazepan-4-yl)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 97::US10905688, Example 97::US11472810, Example 97 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 202 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474217 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474217&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652220 442074414 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998971 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)N2CCOC(C)(C)C2)cc1 InChI=1S/C21H26N4O3/c1-15-12-25-18(11-22-20(25)23-9-10-28-21(2,3)14-23)19(26)24(15)13-16-5-7-17(27-4)8-6-16/h5-8,11-12H,9-10,13-14H2,1-4H3 HVRCNXOHZPZGSJ-UHFFFAOYSA-N 474218 3-(2,2-dimethylmorpholino)-7-(4- methoxybenzyl)-6- methylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 98::US10905688, Example 98::US11472810, Example 98 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 287 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474218 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474218&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652493 442074415 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998974 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)N1CCC2OCC[C@H]12 InChI=1S/C20H21FN4O2/c1-13-11-25-17(19(26)24(13)12-14-3-2-4-15(21)9-14)10-22-20(25)23-7-5-18-16(23)6-8-27-18/h2-4,9-11,16,18H,5-8,12H2,1H3/t16-,18?/m0/s1 YWWHXMUOPZSUDB-ATNAJCNCSA-N 480884 7-(3-fluorobenzyl)-3-(hexahydro- methylimidazo[1,5-a]pyrazin- 8(7H)-one, isomer 2::US10905688, Example 99, isomer 2::US11472810, Example 99, isomer 1 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 241 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=480884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=480884&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 156595982 443550076 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998979 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)[C@@H]1CCCOC1 InChI=1S/C19H20FN3O2/c1-13-10-23-17(9-21-18(23)15-5-3-7-25-12-15)19(24)22(13)11-14-4-2-6-16(20)8-14/h2,4,6,8-10,15H,3,5,7,11-12H2,1H3/t15-/m1/s1 PZKOOBRKCGIRJF-OAHLLOKOSA-N 474219 7-(3-fluorobenzyl)-6-methyl-3- (tetrahydro-2H-pyran-3- yl)imidazo[1,5-a]pyrazin-8(7H)- one, stereoisomer 1::US10858362, Example 100, isomer 1::US10905688, Example 100, isomer 1::US11472810, Example 100, isomer 1 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 306 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474219 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474219&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652485 442074416 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998982 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)[C@H]1CCCOC1 InChI=1S/C19H20FN3O2/c1-13-10-23-17(9-21-18(23)15-5-3-7-25-12-15)19(24)22(13)11-14-4-2-6-16(20)8-14/h2,4,6,8-10,15H,3,5,7,11-12H2,1H3/t15-/m0/s1 PZKOOBRKCGIRJF-HNNXBMFYSA-N 474220 7-(3-fluorobenzyl)-6-methyl-3- (tetrahydro-2H-pyran-3- yl)imidazo[1,5-a]pyrazin-8(7H)- one, stereoisomer 2::US10858362, Example 100, isomer 2::US10905688, Example 100, isomer 2::US11472810, Example 100, isomer 2 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 333 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474220 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474220&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652422 442074417 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997360 O=c1n(CC2CCCCCC2)ccn2c(ncc12)C1CCOCC1 InChI=1S/C19H27N3O2/c23-19-17-13-20-18(16-7-11-24-12-8-16)22(17)10-9-21(19)14-15-5-3-1-2-4-6-15/h9-10,13,15-16H,1-8,11-12,14H2 SGRJQQJTJHBFTK-UHFFFAOYSA-N 474119 7-(Cycloheptylmethyl)-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 12::US10912773, Example 12::US11472810, Example 12 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 30.0 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474119&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652262 442074318 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997363 O=c1n(CC2CCCCCC2)ccn2c(ncc12)C1CC1 InChI=1S/C17H23N3O/c21-17-15-11-18-16(14-7-8-14)20(15)10-9-19(17)12-13-5-3-1-2-4-6-13/h9-11,13-14H,1-8,12H2 YIBKFYWXALCNMI-UHFFFAOYSA-N 474120 7-(Cycloheptylmethyl)-3- cyclopropylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 13::US10912773, Example 13::US11472810, Example 13 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 87.0 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474120&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652224 442074319 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997366 Cc1cn2c(ncc2c(=O)n1Cc1ccc(Cl)cc1)C1CCOCC1 InChI=1S/C19H20ClN3O2/c1-13-11-23-17(10-21-18(23)15-6-8-25-9-7-15)19(24)22(13)12-14-2-4-16(20)5-3-14/h2-5,10-11,15H,6-9,12H2,1H3 YSJUCDCNAYRULZ-UHFFFAOYSA-N 474121 7-(4-Chlorobenzyl)-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 14::US10912773, Example 14::US11472810, Example 14 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 18.0 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474121&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652230 442074320 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997369 Fc1cccc(Cn2c(Br)cn3c(ncc3c2=O)C2CCOCC2)c1 InChI=1S/C18H17BrFN3O2/c19-16-11-22-15(9-21-17(22)13-4-6-25-7-5-13)18(24)23(16)10-12-2-1-3-14(20)8-12/h1-3,8-9,11,13H,4-7,10H2 JVYBBFBHTBCHNY-UHFFFAOYSA-N 474122 6-Bromo-7-(3-fluorobenzyl)-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 15::US10912773, Example 15::US11472810, Example 15 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 58.0 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474122&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652389 442074321 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997372 Cc1cn2c(ncc2c(=O)n1Cc1ccccc1)C1CCOCC1 InChI=1S/C19H21N3O2/c1-14-12-22-17(11-20-18(22)16-7-9-24-10-8-16)19(23)21(14)13-15-5-3-2-4-6-15/h2-6,11-12,16H,7-10,13H2,1H3 JBXKPHLWRUHDIB-UHFFFAOYSA-N 474123 7-Benzyl-6-methyl-3-(tetrahydro- 2H-pyran-4-yl)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 16::US10912773, Example 16::US11472810, Example 16 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 85.0 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474123&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652416 442074322 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997375 Cc1cn2c(ncc2c(=O)n1Cc1ccccc1F)C1CCOCC1 InChI=1S/C19H20FN3O2/c1-13-11-23-17(10-21-18(23)14-6-8-25-9-7-14)19(24)22(13)12-15-4-2-3-5-16(15)20/h2-5,10-11,14H,6-9,12H2,1H3 SGDZBPUOHUWTHZ-UHFFFAOYSA-N 474124 7-(2-Fluorobenzyl)-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 17::US10912773, Example 17::US11472810, Example 17 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 42.0 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474124&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652218 442074323 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997378 Cc1cn2c(ncc2c(=O)n1Cc1cccc(Cl)c1)C1CCOCC1 InChI=1S/C19H20ClN3O2/c1-13-11-23-17(10-21-18(23)15-5-7-25-8-6-15)19(24)22(13)12-14-3-2-4-16(20)9-14/h2-4,9-11,15H,5-8,12H2,1H3 FRYCFLNTERXYHU-UHFFFAOYSA-N 474125 7-(3-Chlorobenzyl)-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 18::US10912773, Example 18::US11472810, Example 18 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 57.0 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474125&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652215 442074324 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997381 Cc1cn2c(ncc2c(=O)n1Cc1ccccc1Cl)C1CCOCC1 InChI=1S/C19H20ClN3O2/c1-13-11-23-17(10-21-18(23)14-6-8-25-9-7-14)19(24)22(13)12-15-4-2-3-5-16(15)20/h2-5,10-11,14H,6-9,12H2,1H3 RNBCFPQVHXWYQR-UHFFFAOYSA-N 474126 7-(2-Chlorobenzyl)-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 19::US10912773, Example 19::US11472810, Example 19 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 46.0 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474126&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652210 442074325 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997384 COc1cccc(Cn2c(C)cn3c(ncc3c2=O)C2CCOCC2)c1 InChI=1S/C20H23N3O3/c1-14-12-23-18(11-21-19(23)16-6-8-26-9-7-16)20(24)22(14)13-15-4-3-5-17(10-15)25-2/h3-5,10-12,16H,6-9,13H2,1-2H3 OYBSUAILVMFPHS-UHFFFAOYSA-N 474127 7-(3-Methoxybenzyl)-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 20::US10912773, Example 20::US11472810, Example 20 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 416 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474127&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652387 442074326 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997387 Cc1ccccc1Cn1c(C)cn2c(ncc2c1=O)C1CCOCC1 InChI=1S/C20H23N3O2/c1-14-5-3-4-6-17(14)13-22-15(2)12-23-18(20(22)24)11-21-19(23)16-7-9-25-10-8-16/h3-6,11-12,16H,7-10,13H2,1-2H3 ICFZMMURQAUHKS-UHFFFAOYSA-N 474128 6-Methyl-7-(2-methylbenzyl)-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 21::US10912773, Example 21::US11472810, Example 21 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 242 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474128&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652209 442074327 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997390 Cc1ccc(Cn2c(C)cn3c(ncc3c2=O)C2CCOCC2)cc1 InChI=1S/C20H23N3O2/c1-14-3-5-16(6-4-14)13-22-15(2)12-23-18(20(22)24)11-21-19(23)17-7-9-25-10-8-17/h3-6,11-12,17H,7-10,13H2,1-2H3 NJLBYLKOKZGPPW-UHFFFAOYSA-N 474129 6-Methyl-7-(4-methylbenzyl)-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 22::US10912773, Example 22::US11472810, Example 22 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 75.0 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474129&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652392 442074328 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997393 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C2CCOCC2)cc1 InChI=1S/C20H23N3O3/c1-14-12-23-18(11-21-19(23)16-7-9-26-10-8-16)20(24)22(14)13-15-3-5-17(25-2)6-4-15/h3-6,11-12,16H,7-10,13H2,1-2H3 PUKNFFAMUWZTGI-UHFFFAOYSA-N 474130 7-(4-Methoxybenzyl)-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 23::US10912773, Example 23::US11472810, Example 23 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 14.0 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474130 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474130&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652249 442074329 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997396 Cc1cn2c(ncc2c(=O)n1Cc1ccc(F)cc1)C1CCOCC1 InChI=1S/C19H20FN3O2/c1-13-11-23-17(10-21-18(23)15-6-8-25-9-7-15)19(24)22(13)12-14-2-4-16(20)5-3-14/h2-5,10-11,15H,6-9,12H2,1H3 HTAKTLWSUKQRRS-UHFFFAOYSA-N 474131 7-(4-Fluorobenzyl)-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 24::US10912773, Example 24::US11472810, Example 24 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 38.0 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474131&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652282 442074330 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997399 Cc1cccc(Cn2c(C)cn3c(ncc3c2=O)C2CCOCC2)c1 InChI=1S/C20H23N3O2/c1-14-4-3-5-16(10-14)13-22-15(2)12-23-18(20(22)24)11-21-19(23)17-6-8-25-9-7-17/h3-5,10-12,17H,6-9,13H2,1-2H3 FCLGCXKNDLJHGE-UHFFFAOYSA-N 474132 6-Methyl-7-(3-methylbenzyl)-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 25::US10912773, Example 25::US11472810, Example 25 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 63.0 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474132&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652311 442074331 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997402 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)C1(C)CCOCC1 InChI=1S/C20H22FN3O2/c1-14-12-24-17(11-22-19(24)20(2)6-8-26-9-7-20)18(25)23(14)13-15-4-3-5-16(21)10-15/h3-5,10-12H,6-9,13H2,1-2H3 MVBCAJXPQPBVSA-UHFFFAOYSA-N 474133 7-(3-fluorobenzyl)-6-methyl-3-(4- methyltetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 26::US10912773, Example 26::US11472810, Example 26 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 234 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474133&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652437 442074332 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997405 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)C1(CCOCC1)C#N InChI=1S/C20H19FN4O2/c1-14-11-25-17(10-23-19(25)20(13-22)5-7-27-8-6-20)18(26)24(14)12-15-3-2-4-16(21)9-15/h2-4,9-11H,5-8,12H2,1H3 USXLZPZGBIYQLQ-UHFFFAOYSA-N 474134 4-(7-(3-fluorobenzyl)-6-methyl-8- oxo-7,8-dihydroimidazo[1,5- a]pyrazin-3-yl)tetrahydro-2H- pyran-4-carbonitrile::US10858362, Example 27::US10912773, Example 27::US11472810, Example 27 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 603 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474134&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652325 442074333 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997408 COC1(CCOCC1)c1ncc2n1cc(C)n(Cc1cccc(F)c1)c2=O InChI=1S/C20H22FN3O3/c1-14-12-24-17(11-22-19(24)20(26-2)6-8-27-9-7-20)18(25)23(14)13-15-4-3-5-16(21)10-15/h3-5,10-12H,6-9,13H2,1-2H3 ZCVGFCXGAGKYHH-UHFFFAOYSA-N 474135 7-(3-fluorobenzyl)-3-(4- methoxytetrahydro-2H-pyran-4- yl)-6-methylimidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 28::US10912773, Example 28::US11472810, Example 28 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 663 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474135&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652291 442074334 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997411 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)C1(F)CCOCC1 InChI=1S/C19H19F2N3O2/c1-13-11-24-16(10-22-18(24)19(21)5-7-26-8-6-19)17(25)23(13)12-14-3-2-4-15(20)9-14/h2-4,9-11H,5-8,12H2,1H3 RQWUWJPTWQLWON-UHFFFAOYSA-N 474136 7-(3-fluorobenzyl)-3-(4- fluorotetrahydro-2H-pyran-4-yl)- 6-methylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 29::US10912773, Example 29::US11472810, Example 29 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 493 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474136&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652263 442074335 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997417 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)[C@@H]1CCOC1 InChI=1S/C18H18FN3O2/c1-12-9-22-16(8-20-17(22)14-5-6-24-11-14)18(23)21(12)10-13-3-2-4-15(19)7-13/h2-4,7-9,14H,5-6,10-11H2,1H3/t14-/m1/s1 LEYPTBGWIKQYRW-CQSZACIVSA-N 474139 7-(3-fluorobenzyl)-6-methyl-3- (tetrahydrofuran-3-yl)imidazo[1,5- a]pyrazin-8(7H)-one, stereoisomer 1::US10858362, Example 31, isomer 1::US10905688, Example 31, isomer 1::US11472810, Example 31, isomer 1 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 337 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474139&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652497 442074338 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997420 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)[C@H]1CCOC1 InChI=1S/C18H18FN3O2/c1-12-9-22-16(8-20-17(22)14-5-6-24-11-14)18(23)21(12)10-13-3-2-4-15(19)7-13/h2-4,7-9,14H,5-6,10-11H2,1H3/t14-/m0/s1 LEYPTBGWIKQYRW-AWEZNQCLSA-N 474140 7-(3-fluorobenzyl)-6-methyl-3- (tetrahydrofuran-3-yl)imidazo[1,5- a]pyrazin-8(7H)-one, stereoisomer 2::US10858362, Example 31, isomer 2::US10912773, Example 31-isomer-2::US11472810, Example 31, isomer 2 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 347 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474140 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474140&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652532 442074339 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997423 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)[C@@]1(C)CCOC1 InChI=1S/C19H20FN3O2/c1-13-10-23-16(9-21-18(23)19(2)6-7-25-12-19)17(24)22(13)11-14-4-3-5-15(20)8-14/h3-5,8-10H,6-7,11-12H2,1-2H3/t19-/m0/s1 AQLHITNAEZNQJK-IBGZPJMESA-N 474142 7-(3-fluorobenzyl)-6-methyl-3-(3- methyltetrahydrofuran-3- yl)imidazo[1,5-a]pyrazin-8(7H)- one, stereoisomer 2::US10858362, Example 32, isomer 2::US10912773, Example 32-isomer-2::US11472810, Example 32, isomer 1 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 257 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474142&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652347 442074341 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997426 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)[C@]1(C)CCOC1 InChI=1S/C19H20FN3O2/c1-13-10-23-16(9-21-18(23)19(2)6-7-25-12-19)17(24)22(13)11-14-4-3-5-15(20)8-14/h3-5,8-10H,6-7,11-12H2,1-2H3/t19-/m1/s1 AQLHITNAEZNQJK-LJQANCHMSA-N 474141 7-(3-fluorobenzyl)-6-methyl-3-(3- methyltetrahydrofuran-3- yl)imidazo[1,5-a]pyrazin-8(7H)- one, stereoisomer 1::US10858362, Example 32, isomer 1::US10912773, Example 32-isomer-1::US11472810, Example 32, isomer 2 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 401 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474141 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474141&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652541 442074340 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997429 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)C1(C)CC1 InChI=1S/C18H18FN3O/c1-12-10-22-15(9-20-17(22)18(2)6-7-18)16(23)21(12)11-13-4-3-5-14(19)8-13/h3-5,8-10H,6-7,11H2,1-2H3 VCCNMXVKDHUXGT-UHFFFAOYSA-N 474143 7-(3-fluorobenzyl)-6-methyl-3-(1- methylcyclopropyl)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 33::US10912773, Example 33::US11472810, Example 33 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 94.0 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474143 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474143&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652394 442074342 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997432 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)C1CC1(F)F InChI=1S/C17H14F3N3O/c1-10-8-23-14(7-21-15(23)13-6-17(13,19)20)16(24)22(10)9-11-3-2-4-12(18)5-11/h2-5,7-8,13H,6,9H2,1H3 GEKRVCRUZXROSZ-UHFFFAOYSA-N 474144 3-(2,2-difluorocyclopropyl)-7-(3- fluorobenzyl)-6- methylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 34::US10905688, Example 34::US11472810, Example 34 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 331 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474144&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652478 442074343 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997435 C[C@H]1C[C@H]1c1ncc2n1cc(C)n(Cc1cccc(F)c1)c2=O InChI=1S/C18H18FN3O/c1-11-6-15(11)17-20-8-16-18(23)21(12(2)9-22(16)17)10-13-4-3-5-14(19)7-13/h3-5,7-9,11,15H,6,10H2,1-2H3/t11-,15+/m0/s1 NSFYZWGFIIQKQP-XHDPSFHLSA-N 474145 7-(3-fluorobenzyl)-6-methyl-3-(2- methylcyclopropyl)imidazo[1,5- a]pyrazin-8(7H)-one, stereoisomer 1::US10858362, Example 35, isomer 1::US10912773, Example 35-isomer-1::US11472810, Example 35, isomer 1 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 193 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474145&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652399 442074344 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997438 C[C@@H]1C[C@H]1c1ncc2n1cc(C)n(Cc1cccc(F)c1)c2=O InChI=1S/C18H18FN3O/c1-11-6-15(11)17-20-8-16-18(23)21(12(2)9-22(16)17)10-13-4-3-5-14(19)7-13/h3-5,7-9,11,15H,6,10H2,1-2H3/t11-,15-/m1/s1 NSFYZWGFIIQKQP-IAQYHMDHSA-N 474146 7-(3-fluorobenzyl)-6-methyl-3-(2- methylcyclopropyl)imidazo[1,5- a]pyrazin-8(7H)-one, stereoisomer 2::US10858362, Example 35, isomer 2::US10912773, Example 35-isomer-3::US11472810, Example 35, isomer 2 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 364 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474146&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652492 442074345 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997441 C[C@H]1C[C@@H]1c1ncc2n1cc(C)n(Cc1cccc(F)c1)c2=O InChI=1S/C18H18FN3O/c1-11-6-15(11)17-20-8-16-18(23)21(12(2)9-22(16)17)10-13-4-3-5-14(19)7-13/h3-5,7-9,11,15H,6,10H2,1-2H3/t11-,15-/m0/s1 NSFYZWGFIIQKQP-NHYWBVRUSA-N 474147 7-(3-fluorobenzyl)-6-methyl-3-(2- methylcyclopropyl)imidazo[1,5- a]pyrazin-8(7H)-one, stereoisomer 3::US10858362, Example 35, isomer 3::US10905688, Example 35, isomer 3::US11472810, Example 35, isomer 3 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 82.0 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474147&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652536 442074346 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997446 C[C@H]1OCC[C@H]1c1ncc2n1cc(C)n(Cc1cccc(F)c1)c2=O InChI=1S/C19H20FN3O2/c1-12-10-23-17(9-21-18(23)16-6-7-25-13(16)2)19(24)22(12)11-14-4-3-5-15(20)8-14/h3-5,8-10,13,16H,6-7,11H2,1-2H3/t13-,16-/m1/s1 BZFPDTIGFMRZDI-CZUORRHYSA-N 474149 7-(3-fluorobenzyl)-6-methyl-3-(2- methyltetrahydrofuran-3- yl)imidazo[1,5-a]pyrazin-8(7H)- one, stereoisomer 1::US10858362, Example 36, isomer 1::US10912773, Example 36-isomer-1::US11472810, Example 36, isomer 1 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 152 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474149&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652377 442074348 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997449 C[C@@H]1OCC[C@H]1c1ncc2n1cc(C)n(Cc1cccc(F)c1)c2=O InChI=1S/C19H20FN3O2/c1-12-10-23-17(9-21-18(23)16-6-7-25-13(16)2)19(24)22(12)11-14-4-3-5-15(20)8-14/h3-5,8-10,13,16H,6-7,11H2,1-2H3/t13-,16+/m0/s1 BZFPDTIGFMRZDI-XJKSGUPXSA-N 474151 7-(3-fluorobenzyl)-6-methyl-3-(2- methyltetrahydrofuran-3- yl)imidazo[1,5-a]pyrazin-8(7H)- one, stereoisomer 3::US10858362, Example 36, isomer 3::US10912773, Example 36-isomer-3::US11472810, Example 36, isomer 2 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 282 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474151 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474151&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652488 442074350 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997452 C[C@H]1OCC[C@@H]1c1ncc2n1cc(C)n(Cc1cccc(F)c1)c2=O InChI=1S/C19H20FN3O2/c1-12-10-23-17(9-21-18(23)16-6-7-25-13(16)2)19(24)22(12)11-14-4-3-5-15(20)8-14/h3-5,8-10,13,16H,6-7,11H2,1-2H3/t13-,16+/m1/s1 BZFPDTIGFMRZDI-CJNGLKHVSA-N 474150 7-(3-fluorobenzyl)-6-methyl-3-(2- methyltetrahydrofuran-3- yl)imidazo[1,5-a]pyrazin-8(7H)- one, stereoisomer 2::US10858362, Example 36, isomer 2::US10912773, Example 36-isomer-2::US11472810, Example 36, isomer 3 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 77.0 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474150&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652487 442074349 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997455 C[C@@H]1OCC[C@@H]1c1ncc2n1cc(C)n(Cc1cccc(F)c1)c2=O InChI=1S/C19H20FN3O2/c1-12-10-23-17(9-21-18(23)16-6-7-25-13(16)2)19(24)22(12)11-14-4-3-5-15(20)8-14/h3-5,8-10,13,16H,6-7,11H2,1-2H3/t13-,16-/m0/s1 BZFPDTIGFMRZDI-BBRMVZONSA-N 474152 7-(3-fluorobenzyl)-6-methyl-3-(2- methyltetrahydrofuran-3- yl)imidazo[1,5-a]pyrazin-8(7H)- one, stereoisomer 4::US10858362, Example 36, isomer 4::US10912773, Example 36-isomer-4::US11472810, Example 36, isomer 4 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 51.0 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474152&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652474 442074351 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997457 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)[C@@H]1C[C@@H]1F InChI=1S/C17H15F2N3O/c1-10-8-22-15(7-20-16(22)13-6-14(13)19)17(23)21(10)9-11-3-2-4-12(18)5-11/h2-5,7-8,13-14H,6,9H2,1H3/t13-,14+/m1/s1 MVVQNOPLTGEXNR-KGLIPLIRSA-N 480821 7-(3-fluorobenzyl)-3-(cis-2- methylimidazo[1,5-a]pyrazin- 8(7H)-one, stereoisomer 1::US10905688, Example 37, isomer 1::US11472810, Example 37, isomer 1 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1140 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=480821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=480821&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652268 443550013 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997460 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)[C@H]1C[C@@H]1F InChI=1S/C17H15F2N3O/c1-10-8-22-15(7-20-16(22)13-6-14(13)19)17(23)21(10)9-11-3-2-4-12(18)5-11/h2-5,7-8,13-14H,6,9H2,1H3/t13-,14-/m0/s1 MVVQNOPLTGEXNR-KBPBESRZSA-N 474155 7-(3-fluorobenzyl)-3-(trans-2- fluorocyclopropyl)-6- methylimidazo[1,5-a]pyrazin- 8(7H)-one, stereoisomer 1::US10858362, Example 38, isomer 1::US10905688, Example 37, isomer 2::US11472810, Example 37, isomer 2 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 149 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474155&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652432 442074354 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997463 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)[C@@H]1C[C@H]1F InChI=1S/C17H15F2N3O/c1-10-8-22-15(7-20-16(22)13-6-14(13)19)17(23)21(10)9-11-3-2-4-12(18)5-11/h2-5,7-8,13-14H,6,9H2,1H3/t13-,14-/m1/s1 MVVQNOPLTGEXNR-ZIAGYGMSSA-N 474154 7-(3-fluorobenzyl)-3-(cis-2- fluorocyclopropyl)-6- methylimidazo[1,5-a]pyrazin- 8(7H)-one, stereoisomer 2::US10858362, Example 37, isomer 2::US10905688, Example 38, isomer 1 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 582 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474154&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652341 442074353 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997466 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)[C@H]1C[C@H]1F InChI=1S/C17H15F2N3O/c1-10-8-22-15(7-20-16(22)13-6-14(13)19)17(23)21(10)9-11-3-2-4-12(18)5-11/h2-5,7-8,13-14H,6,9H2,1H3/t13-,14+/m0/s1 MVVQNOPLTGEXNR-UONOGXRCSA-N 474156 7-(3-fluorobenzyl)-3-(trans-2- fluorocyclopropyl)-6- methylimidazo[1,5-a]pyrazin- 8(7H)-one, stereoisomer 2::US10858362, Example 38, isomer 2::US10905688, Example 38, isomer 2::US11472810, Example 38, isomer 2 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 667 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474156&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652469 442074355 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997469 Cc1cn2c(ncc2c(=O)n1Cc1ccc(OC2CC2)cc1)C1CCOCC1 InChI=1S/C22H25N3O3/c1-15-13-25-20(12-23-21(25)17-8-10-27-11-9-17)22(26)24(15)14-16-2-4-18(5-3-16)28-19-6-7-19/h2-5,12-13,17,19H,6-11,14H2,1H3 RVWGYNGTLDYNPU-UHFFFAOYSA-N 474157 7-(4-cyclopropoxybenzyl)-6- methyl-3-(tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 39::US10912773, Example 39::US11472810, Example 39 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 413 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474157&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652459 442074356 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997472 Cc1cn2c(ncc2c(=O)n1Cc1ccc(OC(F)F)cc1)C1CCOCC1 InChI=1S/C20H21F2N3O3/c1-13-11-25-17(10-23-18(25)15-6-8-27-9-7-15)19(26)24(13)12-14-2-4-16(5-3-14)28-20(21)22/h2-5,10-11,15,20H,6-9,12H2,1H3 QPWYRFGVZKZRGE-UHFFFAOYSA-N 474158 7-(4-(difluoromethoxy)benzyl)-6- methyl-3-(tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 40::US10912773, Example 40::US11472810, Example 40 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 73.0 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474158&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652417 442074357 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997475 Cc1cn2c(ncc2c(=O)n1Cc1ccc(OC(F)(F)F)cc1)C1CCOCC1 InChI=1S/C20H20F3N3O3/c1-13-11-26-17(10-24-18(26)15-6-8-28-9-7-15)19(27)25(13)12-14-2-4-16(5-3-14)29-20(21,22)23/h2-5,10-11,15H,6-9,12H2,1H3 UNRQWEFTRALILW-UHFFFAOYSA-N 474159 6-methyl-3-(tetrahydro-2H-pyran- 4-yl)-7-(4- (trifluoromethoxy)benzyl)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 41::US10912773, Example 41::US11472810, Example 41 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 27.0 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474159&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652254 442074358 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997479 CCc1cn2c(ncc2c(=O)n1Cc1ccccc1)C1CCOCC1 InChI=1S/C20H23N3O2/c1-2-17-14-23-18(12-21-19(23)16-8-10-25-11-9-16)20(24)22(17)13-15-6-4-3-5-7-15/h3-7,12,14,16H,2,8-11,13H2,1H3 LEQLMZLBAGAUDL-UHFFFAOYSA-N 474161 7-benzyl-6-ethyl-3-(tetrahydro- 2H-pyran-4-yl)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 43::US10912773, Example 43::US11472810, Example 43 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 105 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474161&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652424 442074360 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997482 CCc1cn2c(ncc2c(=O)n1Cc1ccc(OC)cc1)C1CCOCC1 InChI=1S/C21H25N3O3/c1-3-17-14-24-19(12-22-20(24)16-8-10-27-11-9-16)21(25)23(17)13-15-4-6-18(26-2)7-5-15/h4-7,12,14,16H,3,8-11,13H2,1-2H3 IHHHPGCUSMYQHX-UHFFFAOYSA-N 474162 6-ethyl-7-(4-methoxybenzyl)-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 44::US10912773, Example 44::US11472810, Example 44 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 40.0 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474162&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652232 442074361 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997485 Cc1cn2c(ncc2c(=O)n1Cc1cccc(c1)C#N)C1CCOCC1 InChI=1S/C20H20N4O2/c1-14-12-24-18(11-22-19(24)17-5-7-26-8-6-17)20(25)23(14)13-16-4-2-3-15(9-16)10-21/h2-4,9,11-12,17H,5-8,13H2,1H3 HBKUUJGKQVTMIE-UHFFFAOYSA-N 474163 3-((6-methyl-8-oxo-3-(tetrahydro- 2H-pyran-4-yl)imidazo[1,5- a]pyrazin-7(8H)- yl)methyl)benzonitrile::US10858362, Example 45::US10912773, Example 45::US11472810, Example 45 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 64.0 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474163&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652242 442074362 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997487 Cc1cn2c(ncc2c(=O)n1Cc1ccc(cc1)C#N)C1CCOCC1 InChI=1S/C20H20N4O2/c1-14-12-24-18(11-22-19(24)17-6-8-26-9-7-17)20(25)23(14)13-16-4-2-15(10-21)3-5-16/h2-5,11-12,17H,6-9,13H2,1H3 LQAZSSIUEDYCBP-UHFFFAOYSA-N 474164 4-((6-methyl-8-oxo-3-(tetrahydro- 2H-pyran-4-yl)imidazo[1,5- a]pyrazin-7(8H)- yl)methyl)benzonitrile::US10858362, Example 46::US10912773, Example 46::US11472810, Example 46 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 809 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474164&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652248 442074363 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997489 CCc1ccccc1Cn1c(C)cn2c(ncc2c1=O)C1CCOCC1 InChI=1S/C21H25N3O2/c1-3-16-6-4-5-7-18(16)14-23-15(2)13-24-19(21(23)25)12-22-20(24)17-8-10-26-11-9-17/h4-7,12-13,17H,3,8-11,14H2,1-2H3 HLXDXKMIVTXPEU-UHFFFAOYSA-N 474166 7-(2-ethylbenzyl)-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 49::US10912773, Example 49::US11472810, Example 49 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 44.0 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474166&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652447 442074365 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997491 Cc1cn2c(ncc2c(=O)n1Cc1ccc2OCOc2c1)C1CCOCC1 InChI=1S/C20H21N3O4/c1-13-10-23-16(9-21-19(23)15-4-6-25-7-5-15)20(24)22(13)11-14-2-3-17-18(8-14)27-12-26-17/h2-3,8-10,15H,4-7,11-12H2,1H3 ZABNCYCWYYVHOF-UHFFFAOYSA-N 474167 7-(benzo[d][1,3]dioxol-5- ylmethyl)-6-methyl-3-(tetrahydro- 2H-pyran-4-yl)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 50::US10912773, Example 50::US11472810, Example 50 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 50.0 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474167 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474167&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652367 442074366 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997494 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C2CCOCC2)cc1Cl InChI=1S/C20H22ClN3O3/c1-13-11-24-17(10-22-19(24)15-5-7-27-8-6-15)20(25)23(13)12-14-3-4-18(26-2)16(21)9-14/h3-4,9-11,15H,5-8,12H2,1-2H3 AKDKVOQBJMHADC-UHFFFAOYSA-N 474168 7-(3-chloro-4-methoxybenzyl)-6- methyl-3-(tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 51::US10912773, Example 51::US11472810, Example 51 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 199 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474168&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652468 442074367 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997498 Cc1cn2c(ncc2c(=O)n1Cc1ccc(O)cc1)C1CCOCC1 InChI=1S/C19H21N3O3/c1-13-11-22-17(10-20-18(22)15-6-8-25-9-7-15)19(24)21(13)12-14-2-4-16(23)5-3-14/h2-5,10-11,15,23H,6-9,12H2,1H3 HWZIGTUHYHCMIT-UHFFFAOYSA-N 474170 7-(4-hydroxybenzyl)-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 53::US10912773, Example 53::US11472810, Example 53 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 401 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474170&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652448 442074369 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997501 CCc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)C1CCOCC1 InChI=1S/C20H22FN3O2/c1-2-17-13-24-18(11-22-19(24)15-6-8-26-9-7-15)20(25)23(17)12-14-4-3-5-16(21)10-14/h3-5,10-11,13,15H,2,6-9,12H2,1H3 AFONMYZRPMFJAB-UHFFFAOYSA-N 474171 6-ethyl-7-(3-fluorobenzyl)-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 54::US10912773, Example 54::US11472810, Example 54 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 62.0 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474171&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652310 442074370 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997504 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)[C@@H]2CCO[C@@H]2C)cc1 InChI=1S/C20H23N3O3/c1-13-11-23-18(10-21-19(23)17-8-9-26-14(17)2)20(24)22(13)12-15-4-6-16(25-3)7-5-15/h4-7,10-11,14,17H,8-9,12H2,1-3H3/t14-,17-/m1/s1 PZHZVFDPQAUVKV-RHSMWYFYSA-N 474172 7-(4-methoxybenzyl)-6-methyl-3- (2-methyltetrahydrofuran-3- yl)imidazo[1,5-a]pyrazin-8(7H)- one, stereoisomer 1::US10858362, Example 55, isomer 1::US10912773, Example 55-isomer-1::US11472810, Example 55, isomer 1 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 20.0 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474172 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474172&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652364 442074371 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997507 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)[C@@H]2CCO[C@H]2C)cc1 InChI=1S/C20H23N3O3/c1-13-11-23-18(10-21-19(23)17-8-9-26-14(17)2)20(24)22(13)12-15-4-6-16(25-3)7-5-15/h4-7,10-11,14,17H,8-9,12H2,1-3H3/t14-,17+/m0/s1 PZHZVFDPQAUVKV-WMLDXEAASA-N 474173 7-(4-methoxybenzyl)-6-methyl-3- (2-methyltetrahydrofuran-3- yl)imidazo[1,5-a]pyrazin-8(7H)- one, stereoisomer 2::US10858362, Example 55, isomer 2::US10858362, Example 55, isomer 3::US10912773, Example 55-isomer-2::US11472810, Example 55, isomer 2 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 86.0 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474173&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652531 442074372 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997510 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)[C@H]2CCO[C@@H]2C)cc1 InChI=1S/C20H23N3O3/c1-13-11-23-18(10-21-19(23)17-8-9-26-14(17)2)20(24)22(13)12-15-4-6-16(25-3)7-5-15/h4-7,10-11,14,17H,8-9,12H2,1-3H3/t14-,17+/m1/s1 PZHZVFDPQAUVKV-PBHICJAKSA-N 480842 7-(4-methoxybenzyl)-6-methyl-3- yl)imidazo[1,5-a]pyrazin-8(7H)- one, stereoisomer 3::US10905688, Example 55, isomer 3::US11472810, Example 55, isomer 3 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 13.0 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=480842 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=480842&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652462 443550034 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997513 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)[C@H]2CCO[C@H]2C)cc1 InChI=1S/C20H23N3O3/c1-13-11-23-18(10-21-19(23)17-8-9-26-14(17)2)20(24)22(13)12-15-4-6-16(25-3)7-5-15/h4-7,10-11,14,17H,8-9,12H2,1-3H3/t14-,17-/m0/s1 PZHZVFDPQAUVKV-YOEHRIQHSA-N 474175 7-(4-methoxybenzyl)-6-methyl-3- (2-methyltetrahydrofuran-3- yl)imidazo[1,5-a]pyrazin-8(7H)- one, stereoisomer 4::US10858362, Example 55, isomer 4::US10905688, Example 55, isomer 4::US11472810, Example 55, isomer 4 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 137 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474175 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474175&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652443 442074373 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997516 CCCc1ncc2n1cc(C)n(Cc1ccc(OC)cc1)c2=O InChI=1S/C18H21N3O2/c1-4-5-17-19-10-16-18(22)20(13(2)11-21(16)17)12-14-6-8-15(23-3)9-7-14/h6-11H,4-5,12H2,1-3H3 YMHRUXWRFFVZTC-UHFFFAOYSA-N 474176 7-(4-methoxybenzyl)-6-methyl-3- propylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 56::US10912773, Example 56::US11472810, Example 56 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 65.0 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474176 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474176&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652426 442074374 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997519 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C2CCOCC2)cn1 InChI=1S/C19H22N4O3/c1-13-11-23-16(10-21-18(23)15-5-7-26-8-6-15)19(24)22(13)12-14-3-4-17(25-2)20-9-14/h3-4,9-11,15H,5-8,12H2,1-2H3 OVPVMIDVNMKKNU-UHFFFAOYSA-N 474177 7-((6-methoxypyridin-3- yl)methyl)-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 57::US10912773, Example 57::US11472810, Example 57 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 45.0 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474177 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474177&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652538 442074375 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997523 CCn1c(C)cn2c(ncc2c1=O)C1CCOCC1 InChI=1S/C14H19N3O2/c1-3-16-10(2)9-17-12(14(16)18)8-15-13(17)11-4-6-19-7-5-11/h8-9,11H,3-7H2,1-2H3 WESIRYTURBTMCP-UHFFFAOYSA-N 474179 7-ethyl-6-methyl-3-(tetrahydro- 2H-pyran-4-yl)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 59::US10912773, Example 59::US11472810, Example 59 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2333 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474179 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474179&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652457 442074377 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997526 CCCn1c(C)cn2c(ncc2c1=O)C1CCOCC1 InChI=1S/C15H21N3O2/c1-3-6-17-11(2)10-18-13(15(17)19)9-16-14(18)12-4-7-20-8-5-12/h9-10,12H,3-8H2,1-2H3 ARICWMJJQKCTDR-UHFFFAOYSA-N 474180 6-methyl-7-propyl-3-(tetrahydro- 2H-pyran-4-yl)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 60::US10912773, Example 60::US11472810, Example 60 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 810 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474180 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474180&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652455 442074378 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997529 CC(C)CCn1c(C)cn2c(ncc2c1=O)C1CCOCC1 InChI=1S/C17H25N3O2/c1-12(2)4-7-19-13(3)11-20-15(17(19)21)10-18-16(20)14-5-8-22-9-6-14/h10-12,14H,4-9H2,1-3H3 OEYDINZBWMRAIK-UHFFFAOYSA-N 474181 7-isopentyl-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 62::US10912773, Example 62::US11472810, Example 62 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1078 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474181&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652305 442074379 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997532 Cc1cn2c(ncc2c(=O)n1CC1CCCC1)C1CCOCC1 InChI=1S/C18H25N3O2/c1-13-11-21-16(10-19-17(21)15-6-8-23-9-7-15)18(22)20(13)12-14-4-2-3-5-14/h10-11,14-15H,2-9,12H2,1H3 IVIOKHSMYSCNPJ-UHFFFAOYSA-N 474182 7-(cyclopentylmethyl)-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 63::US10912773, Example 63::US11472810, Example 63 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 183 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474182 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474182&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652331 442074380 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997535 Cc1cn2c(ncc2c(=O)n1Cc1ccccc1C#N)C1CCOCC1 InChI=1S/C20H20N4O2/c1-14-12-24-18(11-22-19(24)15-6-8-26-9-7-15)20(25)23(14)13-17-5-3-2-4-16(17)10-21/h2-5,11-12,15H,6-9,13H2,1H3 ISOFGIBMBLOJRH-UHFFFAOYSA-N 474183 2-((6-methyl-8-oxo-3-(tetrahydro- 2H-pyran-4-yl)imidazo[1,5- a]pyrazin-7(8H)- yl)methyl)benzonitrile::US10858362, Example 64::US10912773, Example 64::US11472810, Example 64 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 624 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474183&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652237 442074381 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997538 Cc1cn2c(ncc2c(=O)n1CC1CCCCCC1)C1CCOCC1 InChI=1S/C20H29N3O2/c1-15-13-23-18(12-21-19(23)17-8-10-25-11-9-17)20(24)22(15)14-16-6-4-2-3-5-7-16/h12-13,16-17H,2-11,14H2,1H3 FIIDAEWKLGRESO-UHFFFAOYSA-N 474184 7-(cycloheptylmethyl)-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 65::US10912773, Example 65::US11472810, Example 65 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 10.00 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474184 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474184&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652324 442074382 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997541 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C2CCOCC2C)cc1 InChI=1S/C21H25N3O3/c1-14-13-27-9-8-18(14)20-22-10-19-21(25)23(15(2)11-24(19)20)12-16-4-6-17(26-3)7-5-16/h4-7,10-11,14,18H,8-9,12-13H2,1-3H3 YTOUKKHZMQVQLZ-UHFFFAOYSA-N 474189 7-(4-methoxybenzyl)-6-methyl-3- (3-methyltetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 69::US10912773, Example 69::US11472810, Example 69 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 13.0 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474189&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652323 442074386 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997544 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C2(C)CC3CCC2O3)cc1 InChI=1S/C22H25N3O3/c1-14-12-25-18(11-23-21(25)22(2)10-17-8-9-19(22)28-17)20(26)24(14)13-15-4-6-16(27-3)7-5-15/h4-7,11-12,17,19H,8-10,13H2,1-3H3 NRIDLTZEDZLZBY-UHFFFAOYSA-N 474190 7-(4-methoxybenzyl)-6-methyl-3- ((1R,2R,4S)-2-methyl-7- oxabicyclo[2.2.1]heptan-2- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 70::US10912773, Example 70::US11472810, Example 70 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 29.0 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474190 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474190&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122663821 442074387 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997547 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)[C@@H](C)c2ccccc2)cc1 InChI=1S/C23H23N3O2/c1-16-14-26-21(13-24-22(26)17(2)19-7-5-4-6-8-19)23(27)25(16)15-18-9-11-20(28-3)12-10-18/h4-14,17H,15H2,1-3H3/t17-/m0/s1 SWHFTCTZWOUUQD-KRWDZBQOSA-N 474191 (S)-7-(4-methoxybenzyl)-6- methyl-3-(1- phenylethyl)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 71::US10912773, Example 71::US11472810, Example 71 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 211 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474191 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474191&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652214 442074388 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997550 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)[C@H](C)c2ccccc2)cc1 InChI=1S/C23H23N3O2/c1-16-14-26-21(13-24-22(26)17(2)19-7-5-4-6-8-19)23(27)25(16)15-18-9-11-20(28-3)12-10-18/h4-14,17H,15H2,1-3H3/t17-/m1/s1 SWHFTCTZWOUUQD-QGZVFWFLSA-N 474192 (R)-7-(4-methoxybenzyl)-6- methyl-3-(1- phenylethyl)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 72::US10912773, Example 72::US11472810, Example 72 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 90.0 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474192&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652402 442074389 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997553 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C2(C)CCN(C)CC2)cc1 InChI=1S/C22H28N4O2/c1-16-14-26-19(13-23-21(26)22(2)9-11-24(3)12-10-22)20(27)25(16)15-17-5-7-18(28-4)8-6-17/h5-8,13-14H,9-12,15H2,1-4H3 UOMHYPRQAMXYDQ-UHFFFAOYSA-N 474193 3-(1,4-dimethylpiperidin-4-yl)-7- (4-methoxybenzyl)-6- methylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 73::US10912773, Example 73::US11472810, Example 73 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1923 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474193 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474193&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652233 442074390 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997556 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C2CCc3ccc(Cl)cc23)cc1 InChI=1S/C24H22ClN3O2/c1-15-13-28-22(24(29)27(15)14-16-3-8-19(30-2)9-4-16)12-26-23(28)20-10-6-17-5-7-18(25)11-21(17)20/h3-5,7-9,11-13,20H,6,10,14H2,1-2H3 COANVSPOSPBLGF-UHFFFAOYSA-N 474194 3-(6-chloro-2,3-dihydro-1H- inden-1-yl)-7-(4-methoxybenzyl)- 6-methylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 74::US10912773, Example 74::US11472810, Example 74 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 5.00 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474194 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474194&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652306 442074391 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997559 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C2(C)CNC(=O)C2)cc1 InChI=1S/C20H22N4O3/c1-13-10-24-16(9-21-19(24)20(2)8-17(25)22-12-20)18(26)23(13)11-14-4-6-15(27-3)7-5-14/h4-7,9-10H,8,11-12H2,1-3H3,(H,22,25) XKGOGXSNJQICIE-UHFFFAOYSA-N 474195 7-(4-methoxybenzyl)-6-methyl-3- (3-methyl-5-oxopyrrolidin-3- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 75::US10912773, Example 75::US11472810, Example 75 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 236 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474195&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652486 442074392 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997562 COCC(C)(C)c1ncc2n1cc(C)n(Cc1ccc(OC)cc1)c2=O InChI=1S/C20H25N3O3/c1-14-11-23-17(10-21-19(23)20(2,3)13-25-4)18(24)22(14)12-15-6-8-16(26-5)9-7-15/h6-11H,12-13H2,1-5H3 ANGLWHGRWFOZSQ-UHFFFAOYSA-N 474196 3-(1-methoxy-2-methylpropan-2- yl)-7-(4-methoxybenzyl)-6- methylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 76::US10912773, Example 76::US11472810, Example 76 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 122 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474196 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474196&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652293 442074393 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997565 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C(C)C)cc1 InChI=1S/C18H21N3O2/c1-12(2)17-19-9-16-18(22)20(13(3)10-21(16)17)11-14-5-7-15(23-4)8-6-14/h5-10,12H,11H2,1-4H3 RVHZRSIRMVWVKL-UHFFFAOYSA-N 474197 3-isopropyl-7-(4-methoxybenzyl)- 6-methylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 77::US10912773, Example 77::US11472810, Example 77 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 13.0 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474197 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474197&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652354 442074394 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997568 Cc1nc(Cn2c(C)cn3c(ncc3c2=O)C2CCOCC2)cs1 InChI=1S/C17H20N4O2S/c1-11-8-21-15(7-18-16(21)13-3-5-23-6-4-13)17(22)20(11)9-14-10-24-12(2)19-14/h7-8,10,13H,3-6,9H2,1-2H3 SFJUWCCYAPWXBB-UHFFFAOYSA-N 474198 6-methyl-7-((2-methylthiazol-4- yl)methyl)-3-(tetrahydro-2H- pyran-4-yl)imidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 78::US10912773, Example 78::US11472810, Example 78 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1691 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474198 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474198&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652259 442074395 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997571 Cc1cn2c(ncc2c(=O)n1Cc1ccsc1)C1CCOCC1 InChI=1S/C17H19N3O2S/c1-12-9-20-15(8-18-16(20)14-2-5-22-6-3-14)17(21)19(12)10-13-4-7-23-11-13/h4,7-9,11,14H,2-3,5-6,10H2,1H3 VRSLRMWKAICODM-UHFFFAOYSA-N 474199 6-methyl-3-(tetrahydro-2H-pyran- 4-yl)-7-(thiophen-3- ylmethyl)imidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 79::US10905688, Example 79 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 228 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474199 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474199&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652355 442074396 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997579 Cc1cc(Cn2c(C)cn3c(ncc3c2=O)C2CCOCC2)on1 InChI=1S/C17H20N4O3/c1-11-7-14(24-19-11)10-20-12(2)9-21-15(17(20)22)8-18-16(21)13-3-5-23-6-4-13/h7-9,13H,3-6,10H2,1-2H3 ZKIKXHAKXUODEV-UHFFFAOYSA-N 474203 6-methyl-7-((3-methylisoxazol-5- yl)methyl)-3-(tetrahydro-2H- pyran-4-yl)imidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 83::US10912773, Example 83::US11472810, Example 83 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4444 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474203 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474203&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652332 442074400 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997582 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C2CC(C)OC(C)C2)cc1 InChI=1S/C22H27N3O3/c1-14-12-25-20(11-23-21(25)18-9-15(2)28-16(3)10-18)22(26)24(14)13-17-5-7-19(27-4)8-6-17/h5-8,11-12,15-16,18H,9-10,13H2,1-4H3 IJXXNTVMDPJVBW-UHFFFAOYSA-N 474204 3-(2,6-dimethyltetrahydro-2H- pyran-4-yl)-7-(4-methoxybenzyl)- 6-methylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 84::US10912773, Example 84::US11472810, Example 84 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 627 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474204 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474204&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652545 442074401 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997585 CCCc1ncc2n1cc(C)n(CC1CCCCC1)c2=O InChI=1S/C17H25N3O/c1-3-7-16-18-10-15-17(21)19(13(2)11-20(15)16)12-14-8-5-4-6-9-14/h10-11,14H,3-9,12H2,1-2H3 ZVDAZHCIEJDXMC-UHFFFAOYSA-N 474205 7-(cyclohexylmethyl)-6-methyl-3- propylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 85::US10912773, Example 85::US11472810, Example 85 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 120 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474205 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474205&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652381 442074402 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997588 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C(C)(C)O)cc1 InChI=1S/C18H21N3O3/c1-12-10-21-15(9-19-17(21)18(2,3)23)16(22)20(12)11-13-5-7-14(24-4)8-6-13/h5-10,23H,11H2,1-4H3 RVJAZKLTOAMCHB-UHFFFAOYSA-N 474206 3-(2-hydroxypropan-2-yl)-7-(4- methoxybenzyl)-6- methylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 86::US10912773, Example 86::US11472810, Example 86 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 193 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474206 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474206&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652382 442074403 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997591 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C(C)(C)F)cc1 InChI=1S/C18H20FN3O2/c1-12-10-22-15(9-20-17(22)18(2,3)19)16(23)21(12)11-13-5-7-14(24-4)8-6-13/h5-10H,11H2,1-4H3 DKRDXFRQADAIHU-UHFFFAOYSA-N 474207 3-(2-fluoropropan-2-yl)-7-(4- methoxybenzyl)-6- methylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 87::US10912773, Example 87::US11472810, Example 87 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 108 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474207 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474207&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652496 442074404 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997594 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C2CCNC(=O)CC2)cc1 InChI=1S/C21H24N4O3/c1-14-12-25-18(11-23-20(25)16-5-8-19(26)22-10-9-16)21(27)24(14)13-15-3-6-17(28-2)7-4-15/h3-4,6-7,11-12,16H,5,8-10,13H2,1-2H3,(H,22,26) ZMTDJXQCSYULBW-UHFFFAOYSA-N 474208 7-(4-methoxybenzyl)-6-methyl-3- (7-oxoazepan-4-yl)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 88::US10912773, Example 88::US11472810, Example 88 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 484 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474208&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652312 442074405 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997599 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C(C)c2nc(C)cs2)cc1 InChI=1S/C21H22N4O2S/c1-13-12-28-20(23-13)15(3)19-22-9-18-21(26)24(14(2)10-25(18)19)11-16-5-7-17(27-4)8-6-16/h5-10,12,15H,11H2,1-4H3 XRYJHUBBBIIQDO-UHFFFAOYSA-N 474210 7-(4-methoxybenzyl)-6-methyl-3- (1-(4-methylthiazol-2- yl)ethyl)imidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 90::US10912773, Example 90::US11472810, Example 90 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 34.0 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474210&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652338 442074407 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997602 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C2(C)CCN(C2)S(N)(=O)=O)cc1 InChI=1S/C20H25N5O4S/c1-14-11-25-17(18(26)24(14)12-15-4-6-16(29-3)7-5-15)10-22-19(25)20(2)8-9-23(13-20)30(21,27)28/h4-7,10-11H,8-9,12-13H2,1-3H3,(H2,21,27,28) RZZDUEKLZBHEJJ-UHFFFAOYSA-N 474211 3-(7-(4-methoxybenzyl)-6-methyl- 8-oxo-7,8-dihydroimidazo[1,5- a]pyrazin-3-yl)-3- methylpyrrolidine-1-sulfonamide::US10858362, Example 91::US10912773, Example 91::US11472810, Example 91 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 181 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474211 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474211&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652235 442074408 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997605 COc1ccc(Cn2c(CC3CCCC3)cn3c(ncc3c2=O)C2CCOCC2)cc1 InChI=1S/C25H31N3O3/c1-30-22-8-6-19(7-9-22)16-27-21(14-18-4-2-3-5-18)17-28-23(25(27)29)15-26-24(28)20-10-12-31-13-11-20/h6-9,15,17-18,20H,2-5,10-14,16H2,1H3 TUNXEGCQHJFZRL-UHFFFAOYSA-N 474212 6-(cyclopentylmethyl)-7-(4- methoxybenzyl)-3-(tetrahydro- 2H-pyran-4-yl)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 92::US10912773, Example 92::US11472810, Example 92 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 71.0 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474212 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474212&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652475 442074409 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997608 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)N2CCOCC2)cc1 InChI=1S/C19H22N4O3/c1-14-12-23-17(11-20-19(23)21-7-9-26-10-8-21)18(24)22(14)13-15-3-5-16(25-2)6-4-15/h3-6,11-12H,7-10,13H2,1-2H3 DRHDVSISCJNWFF-UHFFFAOYSA-N 474213 3-(morpholino)-7-(4- methoxybenzyl)-6- methylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 93::US10912773, Example 93::US11472810, Example 93 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 96.0 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474213&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652234 442074410 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997611 COc1ccc(Cn2c(C)cn3c(NC4CCOC4)ncc3c2=O)cc1 InChI=1S/C19H22N4O3/c1-13-10-23-17(9-20-19(23)21-15-7-8-26-12-15)18(24)22(13)11-14-3-5-16(25-2)6-4-14/h3-6,9-10,15H,7-8,11-12H2,1-2H3,(H,20,21) MVGJRDDRTHNROA-UHFFFAOYSA-N 474214 7-(4-methoxybenzyl)-6-methyl-3- ((tetrahydrofuran-3- yl)amino)imidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 94::US10912773, Example 94::US11472810, Example 94 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2516 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474214 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474214&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652491 442074411 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997614 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)N2CCOC[C@H]2C)cc1 InChI=1S/C20H24N4O3/c1-14-11-24-18(10-21-20(24)22-8-9-27-13-15(22)2)19(25)23(14)12-16-4-6-17(26-3)7-5-16/h4-7,10-11,15H,8-9,12-13H2,1-3H3/t15-/m1/s1 VQUWFLFKDYALSX-OAHLLOKOSA-N 474215 (R)-7-(4-methoxybenzyl)-6- methyl-3-(3- methylmorpholino)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 95::US10912773, Example 95::US11472810, Example 95 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 258 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474215 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474215&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652374 442074412 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997617 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)N2CCOC[C@@H]2C)cc1 InChI=1S/C20H24N4O3/c1-14-11-24-18(10-21-20(24)22-8-9-27-13-15(22)2)19(25)23(14)12-16-4-6-17(26-3)7-5-16/h4-7,10-11,15H,8-9,12-13H2,1-3H3/t15-/m0/s1 VQUWFLFKDYALSX-HNNXBMFYSA-N 474216 (S)-7-(4-methoxybenzyl)-6- methyl-3-(3- methylmorpholino)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 96::US10912773, Example 96::US11472810, Example 96 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 48.0 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474216&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652225 442074413 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997620 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)N2CCCOCC2)cc1 InChI=1S/C20H24N4O3/c1-15-13-24-18(12-21-20(24)22-8-3-10-27-11-9-22)19(25)23(15)14-16-4-6-17(26-2)7-5-16/h4-7,12-13H,3,8-11,14H2,1-2H3 VCAGHSXTTDHBAV-UHFFFAOYSA-N 474217 7-(4-methoxybenzyl)-6-methyl-3- (1,4-oxazepan-4-yl)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 97::US10905688, Example 97::US11472810, Example 97 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 202 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474217 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474217&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652220 442074414 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997623 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)N2CCOC(C)(C)C2)cc1 InChI=1S/C21H26N4O3/c1-15-12-25-18(11-22-20(25)23-9-10-28-21(2,3)14-23)19(26)24(15)13-16-5-7-17(27-4)8-6-16/h5-8,11-12H,9-10,13-14H2,1-4H3 HVRCNXOHZPZGSJ-UHFFFAOYSA-N 474218 3-(2,2-dimethylmorpholino)-7-(4- methoxybenzyl)-6- methylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 98::US10905688, Example 98::US11472810, Example 98 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 287 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474218 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474218&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652493 442074415 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997626 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)N1CCC2OCC[C@@H]12 InChI=1S/C20H21FN4O2/c1-13-11-25-17(19(26)24(13)12-14-3-2-4-15(21)9-14)10-22-20(25)23-7-5-18-16(23)6-8-27-18/h2-4,9-11,16,18H,5-8,12H2,1H3/t16-,18?/m1/s1 YWWHXMUOPZSUDB-PYUWXLGESA-N 480883 7-(3-fluorobenzyl)-3-(hexahydro- methylimidazo[1,5-a]pyrazin- 8(7H)-one, isomer 1::US10905688, Example 99, isomer 1::US11472810, Example 99, isomer 2 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 241 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=480883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=480883&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 156595981 443550075 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997631 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)[C@@H]1CCCOC1 InChI=1S/C19H20FN3O2/c1-13-10-23-17(9-21-18(23)15-5-3-7-25-12-15)19(24)22(13)11-14-4-2-6-16(20)8-14/h2,4,6,8-10,15H,3,5,7,11-12H2,1H3/t15-/m1/s1 PZKOOBRKCGIRJF-OAHLLOKOSA-N 474219 7-(3-fluorobenzyl)-6-methyl-3- (tetrahydro-2H-pyran-3- yl)imidazo[1,5-a]pyrazin-8(7H)- one, stereoisomer 1::US10858362, Example 100, isomer 1::US10905688, Example 100, isomer 1::US11472810, Example 100, isomer 1 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 306 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474219 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474219&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652485 442074416 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 997634 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)[C@H]1CCCOC1 InChI=1S/C19H20FN3O2/c1-13-10-23-17(9-21-18(23)15-5-3-7-25-12-15)19(24)22(13)11-14-4-2-6-16(20)8-14/h2,4,6,8-10,15H,3,5,7,11-12H2,1H3/t15-/m0/s1 PZKOOBRKCGIRJF-HNNXBMFYSA-N 474220 7-(3-fluorobenzyl)-6-methyl-3- (tetrahydro-2H-pyran-3- yl)imidazo[1,5-a]pyrazin-8(7H)- one, stereoisomer 2::US10858362, Example 100, isomer 2::US10905688, Example 100, isomer 2::US11472810, Example 100, isomer 2 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 333 US Patent 10.7270/Q2057K1G aid1805223 US10905688 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474220 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474220&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652422 442074417 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998683 CCCc1ncc2n1ccn(Cc1cccc(F)c1)c2=O InChI=1S/C16H16FN3O/c1-2-4-15-18-10-14-16(21)19(7-8-20(14)15)11-12-5-3-6-13(17)9-12/h3,5-10H,2,4,11H2,1H3 MUGBFEOWKYVLQV-UHFFFAOYSA-N 474108 7-(3-Fluorobenzyl)-3- propylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 1::US10912773, Example 1::US11472810, Example 1 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 801 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474108&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652260 442074307 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998686 Fc1cccc(Cn2c(Cc3ccccc3)cn3c(ncc3c2=O)C2CCOCC2)c1 InChI=1S/C25H24FN3O2/c26-21-8-4-7-19(13-21)16-28-22(14-18-5-2-1-3-6-18)17-29-23(25(28)30)15-27-24(29)20-9-11-31-12-10-20/h1-8,13,15,17,20H,9-12,14,16H2 NTXQTICQWIKNOO-UHFFFAOYSA-N 474109 6-Benzyl-7-(3-fluorobenzyl)-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 2::US10912773, Example 2::US11472810, Example 2 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 51.0 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474109&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652351 442074308 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998689 O=c1n(CC2CCCCC2)c(Cc2ccccc2)cn2c(ncc12)C1CCOCC1 InChI=1S/C25H31N3O2/c29-25-23-16-26-24(21-11-13-30-14-12-21)28(23)18-22(15-19-7-3-1-4-8-19)27(25)17-20-9-5-2-6-10-20/h1,3-4,7-8,16,18,20-21H,2,5-6,9-15,17H2 DDTRHXHSHXSEDF-UHFFFAOYSA-N 474110 6-Benzyl-7-(cyclohexylmethyl)-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 3::US10912773, Example 3::US11472810, Example 3 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.00 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474110&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652211 442074309 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998692 Cc1cn2c(ncc2c(=O)n1CC1CCCCC1)C1CCOCC1 InChI=1S/C19H27N3O2/c1-14-12-22-17(11-20-18(22)16-7-9-24-10-8-16)19(23)21(14)13-15-5-3-2-4-6-15/h11-12,15-16H,2-10,13H2,1H3 XQZACXVVNPRUIZ-UHFFFAOYSA-N 474111 7-(Cyclohexylmethyl)-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 4::US10912773, Example 4::US11472810, Example 4 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 11.0 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474111&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652213 442074310 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998695 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)C1CCOCC1 InChI=1S/C19H20FN3O2/c1-13-11-23-17(10-21-18(23)15-5-7-25-8-6-15)19(24)22(13)12-14-3-2-4-16(20)9-14/h2-4,9-11,15H,5-8,12H2,1H3 DOTFZTSFGIKARD-UHFFFAOYSA-N 474112 7-(3-Fluorobenzyl)-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 5::US10912773, Example 5::US11472810, Example 5 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 108 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474112&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652328 442074311 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998700 O=c1n(CC2CCCCC2)ccn2c(ncc12)C1CC1 InChI=1S/C16H21N3O/c20-16-14-10-17-15(13-6-7-13)19(14)9-8-18(16)11-12-4-2-1-3-5-12/h8-10,12-13H,1-7,11H2 MVICHLUMJUWVOO-UHFFFAOYSA-N 474115 7-(Cyclohexylmethyl)-3- cyclopropylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 8::US10912773, Example 8::US11472810, Example 8 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 252 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474115&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652314 442074314 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998705 O=c1n(CC2CCCCC2)ccn2c(ncc12)C1CCOCC1 InChI=1S/C18H25N3O2/c22-18-16-12-19-17(15-6-10-23-11-7-15)21(16)9-8-20(18)13-14-4-2-1-3-5-14/h8-9,12,14-15H,1-7,10-11,13H2 XXIPRLNKXMMFIK-UHFFFAOYSA-N 474118 7-(Cyclohexylmethyl)-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 11::US10912773, Example 11::US11472810, Example 11 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 113 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474118&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652369 442074317 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998708 O=c1n(CC2CCCCCC2)ccn2c(ncc12)C1CCOCC1 InChI=1S/C19H27N3O2/c23-19-17-13-20-18(16-7-11-24-12-8-16)22(17)10-9-21(19)14-15-5-3-1-2-4-6-15/h9-10,13,15-16H,1-8,11-12,14H2 SGRJQQJTJHBFTK-UHFFFAOYSA-N 474119 7-(Cycloheptylmethyl)-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 12::US10912773, Example 12::US11472810, Example 12 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 30.0 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474119&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652262 442074318 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998711 O=c1n(CC2CCCCCC2)ccn2c(ncc12)C1CC1 InChI=1S/C17H23N3O/c21-17-15-11-18-16(14-7-8-14)20(15)10-9-19(17)12-13-5-3-1-2-4-6-13/h9-11,13-14H,1-8,12H2 YIBKFYWXALCNMI-UHFFFAOYSA-N 474120 7-(Cycloheptylmethyl)-3- cyclopropylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 13::US10912773, Example 13::US11472810, Example 13 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 87.0 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474120&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652224 442074319 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998714 Cc1cn2c(ncc2c(=O)n1Cc1ccc(Cl)cc1)C1CCOCC1 InChI=1S/C19H20ClN3O2/c1-13-11-23-17(10-21-18(23)15-6-8-25-9-7-15)19(24)22(13)12-14-2-4-16(20)5-3-14/h2-5,10-11,15H,6-9,12H2,1H3 YSJUCDCNAYRULZ-UHFFFAOYSA-N 474121 7-(4-Chlorobenzyl)-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 14::US10912773, Example 14::US11472810, Example 14 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 18.0 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474121&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652230 442074320 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998717 Fc1cccc(Cn2c(Br)cn3c(ncc3c2=O)C2CCOCC2)c1 InChI=1S/C18H17BrFN3O2/c19-16-11-22-15(9-21-17(22)13-4-6-25-7-5-13)18(24)23(16)10-12-2-1-3-14(20)8-12/h1-3,8-9,11,13H,4-7,10H2 JVYBBFBHTBCHNY-UHFFFAOYSA-N 474122 6-Bromo-7-(3-fluorobenzyl)-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 15::US10912773, Example 15::US11472810, Example 15 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 58.0 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474122&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652389 442074321 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998720 Cc1cn2c(ncc2c(=O)n1Cc1ccccc1)C1CCOCC1 InChI=1S/C19H21N3O2/c1-14-12-22-17(11-20-18(22)16-7-9-24-10-8-16)19(23)21(14)13-15-5-3-2-4-6-15/h2-6,11-12,16H,7-10,13H2,1H3 JBXKPHLWRUHDIB-UHFFFAOYSA-N 474123 7-Benzyl-6-methyl-3-(tetrahydro- 2H-pyran-4-yl)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 16::US10912773, Example 16::US11472810, Example 16 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 85.0 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474123&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652416 442074322 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998723 Cc1cn2c(ncc2c(=O)n1Cc1ccccc1F)C1CCOCC1 InChI=1S/C19H20FN3O2/c1-13-11-23-17(10-21-18(23)14-6-8-25-9-7-14)19(24)22(13)12-15-4-2-3-5-16(15)20/h2-5,10-11,14H,6-9,12H2,1H3 SGDZBPUOHUWTHZ-UHFFFAOYSA-N 474124 7-(2-Fluorobenzyl)-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 17::US10912773, Example 17::US11472810, Example 17 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 42.0 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474124&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652218 442074323 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998726 Cc1cn2c(ncc2c(=O)n1Cc1cccc(Cl)c1)C1CCOCC1 InChI=1S/C19H20ClN3O2/c1-13-11-23-17(10-21-18(23)15-5-7-25-8-6-15)19(24)22(13)12-14-3-2-4-16(20)9-14/h2-4,9-11,15H,5-8,12H2,1H3 FRYCFLNTERXYHU-UHFFFAOYSA-N 474125 7-(3-Chlorobenzyl)-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 18::US10912773, Example 18::US11472810, Example 18 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 57.0 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474125&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652215 442074324 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998729 Cc1cn2c(ncc2c(=O)n1Cc1ccccc1Cl)C1CCOCC1 InChI=1S/C19H20ClN3O2/c1-13-11-23-17(10-21-18(23)14-6-8-25-9-7-14)19(24)22(13)12-15-4-2-3-5-16(15)20/h2-5,10-11,14H,6-9,12H2,1H3 RNBCFPQVHXWYQR-UHFFFAOYSA-N 474126 7-(2-Chlorobenzyl)-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 19::US10912773, Example 19::US11472810, Example 19 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 46.0 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474126&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652210 442074325 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998732 COc1cccc(Cn2c(C)cn3c(ncc3c2=O)C2CCOCC2)c1 InChI=1S/C20H23N3O3/c1-14-12-23-18(11-21-19(23)16-6-8-26-9-7-16)20(24)22(14)13-15-4-3-5-17(10-15)25-2/h3-5,10-12,16H,6-9,13H2,1-2H3 OYBSUAILVMFPHS-UHFFFAOYSA-N 474127 7-(3-Methoxybenzyl)-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 20::US10912773, Example 20::US11472810, Example 20 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 416 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474127&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652387 442074326 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998735 Cc1ccccc1Cn1c(C)cn2c(ncc2c1=O)C1CCOCC1 InChI=1S/C20H23N3O2/c1-14-5-3-4-6-17(14)13-22-15(2)12-23-18(20(22)24)11-21-19(23)16-7-9-25-10-8-16/h3-6,11-12,16H,7-10,13H2,1-2H3 ICFZMMURQAUHKS-UHFFFAOYSA-N 474128 6-Methyl-7-(2-methylbenzyl)-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 21::US10912773, Example 21::US11472810, Example 21 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 242 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474128&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652209 442074327 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998738 Cc1ccc(Cn2c(C)cn3c(ncc3c2=O)C2CCOCC2)cc1 InChI=1S/C20H23N3O2/c1-14-3-5-16(6-4-14)13-22-15(2)12-23-18(20(22)24)11-21-19(23)17-7-9-25-10-8-17/h3-6,11-12,17H,7-10,13H2,1-2H3 NJLBYLKOKZGPPW-UHFFFAOYSA-N 474129 6-Methyl-7-(4-methylbenzyl)-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 22::US10912773, Example 22::US11472810, Example 22 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 75.0 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474129&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652392 442074328 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998741 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C2CCOCC2)cc1 InChI=1S/C20H23N3O3/c1-14-12-23-18(11-21-19(23)16-7-9-26-10-8-16)20(24)22(14)13-15-3-5-17(25-2)6-4-15/h3-6,11-12,16H,7-10,13H2,1-2H3 PUKNFFAMUWZTGI-UHFFFAOYSA-N 474130 7-(4-Methoxybenzyl)-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 23::US10912773, Example 23::US11472810, Example 23 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 14.0 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474130 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474130&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652249 442074329 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998744 Cc1cn2c(ncc2c(=O)n1Cc1ccc(F)cc1)C1CCOCC1 InChI=1S/C19H20FN3O2/c1-13-11-23-17(10-21-18(23)15-6-8-25-9-7-15)19(24)22(13)12-14-2-4-16(20)5-3-14/h2-5,10-11,15H,6-9,12H2,1H3 HTAKTLWSUKQRRS-UHFFFAOYSA-N 474131 7-(4-Fluorobenzyl)-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 24::US10912773, Example 24::US11472810, Example 24 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 38.0 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474131&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652282 442074330 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998747 Cc1cccc(Cn2c(C)cn3c(ncc3c2=O)C2CCOCC2)c1 InChI=1S/C20H23N3O2/c1-14-4-3-5-16(10-14)13-22-15(2)12-23-18(20(22)24)11-21-19(23)17-6-8-25-9-7-17/h3-5,10-12,17H,6-9,13H2,1-2H3 FCLGCXKNDLJHGE-UHFFFAOYSA-N 474132 6-Methyl-7-(3-methylbenzyl)-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 25::US10912773, Example 25::US11472810, Example 25 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 63.0 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474132&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652311 442074331 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998750 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)C1(C)CCOCC1 InChI=1S/C20H22FN3O2/c1-14-12-24-17(11-22-19(24)20(2)6-8-26-9-7-20)18(25)23(14)13-15-4-3-5-16(21)10-15/h3-5,10-12H,6-9,13H2,1-2H3 MVBCAJXPQPBVSA-UHFFFAOYSA-N 474133 7-(3-fluorobenzyl)-6-methyl-3-(4- methyltetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 26::US10912773, Example 26::US11472810, Example 26 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 234 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474133&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652437 442074332 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998753 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)C1(CCOCC1)C#N InChI=1S/C20H19FN4O2/c1-14-11-25-17(10-23-19(25)20(13-22)5-7-27-8-6-20)18(26)24(14)12-15-3-2-4-16(21)9-15/h2-4,9-11H,5-8,12H2,1H3 USXLZPZGBIYQLQ-UHFFFAOYSA-N 474134 4-(7-(3-fluorobenzyl)-6-methyl-8- oxo-7,8-dihydroimidazo[1,5- a]pyrazin-3-yl)tetrahydro-2H- pyran-4-carbonitrile::US10858362, Example 27::US10912773, Example 27::US11472810, Example 27 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 603 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474134&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652325 442074333 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998756 COC1(CCOCC1)c1ncc2n1cc(C)n(Cc1cccc(F)c1)c2=O InChI=1S/C20H22FN3O3/c1-14-12-24-17(11-22-19(24)20(26-2)6-8-27-9-7-20)18(25)23(14)13-15-4-3-5-16(21)10-15/h3-5,10-12H,6-9,13H2,1-2H3 ZCVGFCXGAGKYHH-UHFFFAOYSA-N 474135 7-(3-fluorobenzyl)-3-(4- methoxytetrahydro-2H-pyran-4- yl)-6-methylimidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 28::US10912773, Example 28::US11472810, Example 28 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 663 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474135&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652291 442074334 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998759 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)C1(F)CCOCC1 InChI=1S/C19H19F2N3O2/c1-13-11-24-16(10-22-18(24)19(21)5-7-26-8-6-19)17(25)23(13)12-14-3-2-4-15(20)9-14/h2-4,9-11H,5-8,12H2,1H3 RQWUWJPTWQLWON-UHFFFAOYSA-N 474136 7-(3-fluorobenzyl)-3-(4- fluorotetrahydro-2H-pyran-4-yl)- 6-methylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 29::US10912773, Example 29::US11472810, Example 29 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 493 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474136&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652263 442074335 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998765 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)C1CCOC1 InChI=1S/C18H18FN3O2/c1-12-9-22-16(8-20-17(22)14-5-6-24-11-14)18(23)21(12)10-13-3-2-4-15(19)7-13/h2-4,7-9,14H,5-6,10-11H2,1H3 LEYPTBGWIKQYRW-UHFFFAOYSA-N 481617 7-(3-fluorobenzyl)-6-methyl-3- yl)imidazo[1,5-a]pyrazin-8(7H)- one, stereoisomer 1::US10912773, Example 31-isomer-1 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 337 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=481617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=481617&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652353 443550790 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998768 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)[C@H]1CCOC1 InChI=1S/C18H18FN3O2/c1-12-9-22-16(8-20-17(22)14-5-6-24-11-14)18(23)21(12)10-13-3-2-4-15(19)7-13/h2-4,7-9,14H,5-6,10-11H2,1H3/t14-/m0/s1 LEYPTBGWIKQYRW-AWEZNQCLSA-N 474140 7-(3-fluorobenzyl)-6-methyl-3- (tetrahydrofuran-3-yl)imidazo[1,5- a]pyrazin-8(7H)-one, stereoisomer 2::US10858362, Example 31, isomer 2::US10912773, Example 31-isomer-2::US11472810, Example 31, isomer 2 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 347 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474140 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474140&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652532 442074339 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998771 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)[C@]1(C)CCOC1 InChI=1S/C19H20FN3O2/c1-13-10-23-16(9-21-18(23)19(2)6-7-25-12-19)17(24)22(13)11-14-4-3-5-15(20)8-14/h3-5,8-10H,6-7,11-12H2,1-2H3/t19-/m1/s1 AQLHITNAEZNQJK-LJQANCHMSA-N 474141 7-(3-fluorobenzyl)-6-methyl-3-(3- methyltetrahydrofuran-3- yl)imidazo[1,5-a]pyrazin-8(7H)- one, stereoisomer 1::US10858362, Example 32, isomer 1::US10912773, Example 32-isomer-1::US11472810, Example 32, isomer 2 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 257 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474141 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474141&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652541 442074340 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998774 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)[C@@]1(C)CCOC1 InChI=1S/C19H20FN3O2/c1-13-10-23-16(9-21-18(23)19(2)6-7-25-12-19)17(24)22(13)11-14-4-3-5-15(20)8-14/h3-5,8-10H,6-7,11-12H2,1-2H3/t19-/m0/s1 AQLHITNAEZNQJK-IBGZPJMESA-N 474142 7-(3-fluorobenzyl)-6-methyl-3-(3- methyltetrahydrofuran-3- yl)imidazo[1,5-a]pyrazin-8(7H)- one, stereoisomer 2::US10858362, Example 32, isomer 2::US10912773, Example 32-isomer-2::US11472810, Example 32, isomer 1 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 401 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474142&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652347 442074341 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998777 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)C1(C)CC1 InChI=1S/C18H18FN3O/c1-12-10-22-15(9-20-17(22)18(2)6-7-18)16(23)21(12)11-13-4-3-5-14(19)8-13/h3-5,8-10H,6-7,11H2,1-2H3 VCCNMXVKDHUXGT-UHFFFAOYSA-N 474143 7-(3-fluorobenzyl)-6-methyl-3-(1- methylcyclopropyl)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 33::US10912773, Example 33::US11472810, Example 33 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 94.0 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474143 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474143&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652394 442074342 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998780 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)[C@H]1CC1(F)F InChI=1S/C17H14F3N3O/c1-10-8-23-14(7-21-15(23)13-6-17(13,19)20)16(24)22(10)9-11-3-2-4-12(18)5-11/h2-5,7-8,13H,6,9H2,1H3/t13-/m1/s1 GEKRVCRUZXROSZ-CYBMUJFWSA-N 481622 3-(2,2-difluorocyclopropyl)-7-(3- fluorobenzyl)-6- methylimidazo[1,5-a]pyrazin- 8(7H)-one::US10912773, Example 34 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 331 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=481622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=481622&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 156596013 443550795 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998783 C[C@H]1C[C@H]1c1ncc2n1cc(C)n(Cc1cccc(F)c1)c2=O InChI=1S/C18H18FN3O/c1-11-6-15(11)17-20-8-16-18(23)21(12(2)9-22(16)17)10-13-4-3-5-14(19)7-13/h3-5,7-9,11,15H,6,10H2,1-2H3/t11-,15+/m0/s1 NSFYZWGFIIQKQP-XHDPSFHLSA-N 474145 7-(3-fluorobenzyl)-6-methyl-3-(2- methylcyclopropyl)imidazo[1,5- a]pyrazin-8(7H)-one, stereoisomer 1::US10858362, Example 35, isomer 1::US10912773, Example 35-isomer-1::US11472810, Example 35, isomer 1 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 193 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474145&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652399 442074344 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998786 C[C@@H]1C[C@H]1c1ncc2n1cc(C)n(Cc1cccc(F)c1)c2=O InChI=1S/C18H18FN3O/c1-11-6-15(11)17-20-8-16-18(23)21(12(2)9-22(16)17)10-13-4-3-5-14(19)7-13/h3-5,7-9,11,15H,6,10H2,1-2H3/t11-,15-/m1/s1 NSFYZWGFIIQKQP-IAQYHMDHSA-N 474146 7-(3-fluorobenzyl)-6-methyl-3-(2- methylcyclopropyl)imidazo[1,5- a]pyrazin-8(7H)-one, stereoisomer 2::US10858362, Example 35, isomer 2::US10912773, Example 35-isomer-3::US11472810, Example 35, isomer 2 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 364 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474146&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652492 442074345 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998789 C[C@@H]1C[C@H]1c1ncc2n1cc(C)n(Cc1cccc(F)c1)c2=O InChI=1S/C18H18FN3O/c1-11-6-15(11)17-20-8-16-18(23)21(12(2)9-22(16)17)10-13-4-3-5-14(19)7-13/h3-5,7-9,11,15H,6,10H2,1-2H3/t11-,15-/m1/s1 NSFYZWGFIIQKQP-IAQYHMDHSA-N 474146 7-(3-fluorobenzyl)-6-methyl-3-(2- methylcyclopropyl)imidazo[1,5- a]pyrazin-8(7H)-one, stereoisomer 2::US10858362, Example 35, isomer 2::US10912773, Example 35-isomer-3::US11472810, Example 35, isomer 2 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 82.0 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474146&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652492 442074345 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998794 C[C@H]1OCC[C@H]1c1ncc2n1cc(C)n(Cc1cccc(F)c1)c2=O InChI=1S/C19H20FN3O2/c1-12-10-23-17(9-21-18(23)16-6-7-25-13(16)2)19(24)22(12)11-14-4-3-5-15(20)8-14/h3-5,8-10,13,16H,6-7,11H2,1-2H3/t13-,16-/m1/s1 BZFPDTIGFMRZDI-CZUORRHYSA-N 474149 7-(3-fluorobenzyl)-6-methyl-3-(2- methyltetrahydrofuran-3- yl)imidazo[1,5-a]pyrazin-8(7H)- one, stereoisomer 1::US10858362, Example 36, isomer 1::US10912773, Example 36-isomer-1::US11472810, Example 36, isomer 1 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 152 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474149&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652377 442074348 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998797 C[C@H]1OCC[C@@H]1c1ncc2n1cc(C)n(Cc1cccc(F)c1)c2=O InChI=1S/C19H20FN3O2/c1-12-10-23-17(9-21-18(23)16-6-7-25-13(16)2)19(24)22(12)11-14-4-3-5-15(20)8-14/h3-5,8-10,13,16H,6-7,11H2,1-2H3/t13-,16+/m1/s1 BZFPDTIGFMRZDI-CJNGLKHVSA-N 474150 7-(3-fluorobenzyl)-6-methyl-3-(2- methyltetrahydrofuran-3- yl)imidazo[1,5-a]pyrazin-8(7H)- one, stereoisomer 2::US10858362, Example 36, isomer 2::US10912773, Example 36-isomer-2::US11472810, Example 36, isomer 3 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 282 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474150&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652487 442074349 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998800 C[C@@H]1OCC[C@H]1c1ncc2n1cc(C)n(Cc1cccc(F)c1)c2=O InChI=1S/C19H20FN3O2/c1-12-10-23-17(9-21-18(23)16-6-7-25-13(16)2)19(24)22(12)11-14-4-3-5-15(20)8-14/h3-5,8-10,13,16H,6-7,11H2,1-2H3/t13-,16+/m0/s1 BZFPDTIGFMRZDI-XJKSGUPXSA-N 474151 7-(3-fluorobenzyl)-6-methyl-3-(2- methyltetrahydrofuran-3- yl)imidazo[1,5-a]pyrazin-8(7H)- one, stereoisomer 3::US10858362, Example 36, isomer 3::US10912773, Example 36-isomer-3::US11472810, Example 36, isomer 2 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 77.0 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474151 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474151&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652488 442074350 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998803 C[C@@H]1OCC[C@@H]1c1ncc2n1cc(C)n(Cc1cccc(F)c1)c2=O InChI=1S/C19H20FN3O2/c1-12-10-23-17(9-21-18(23)16-6-7-25-13(16)2)19(24)22(12)11-14-4-3-5-15(20)8-14/h3-5,8-10,13,16H,6-7,11H2,1-2H3/t13-,16-/m0/s1 BZFPDTIGFMRZDI-BBRMVZONSA-N 474152 7-(3-fluorobenzyl)-6-methyl-3-(2- methyltetrahydrofuran-3- yl)imidazo[1,5-a]pyrazin-8(7H)- one, stereoisomer 4::US10858362, Example 36, isomer 4::US10912773, Example 36-isomer-4::US11472810, Example 36, isomer 4 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 51.0 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474152&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652474 442074351 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998805 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)C1C[C@@H]1F InChI=1S/C17H15F2N3O/c1-10-8-22-15(7-20-16(22)13-6-14(13)19)17(23)21(10)9-11-3-2-4-12(18)5-11/h2-5,7-8,13-14H,6,9H2,1H3/t13?,14-/m0/s1 MVVQNOPLTGEXNR-KZUDCZAMSA-N 474153 7-(3-fluorobenzyl)-3-(cis-2- fluorocyclopropyl)-6- methylimidazo[1,5-a]pyrazin- 8(7H)-one, stereoisomer 1::US10858362, Example 37, isomer 1::US10912773, Example 38-isomer-1 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1140 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474153&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122663819 442074352 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998808 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)C1C[C@@H]1F InChI=1S/C17H15F2N3O/c1-10-8-22-15(7-20-16(22)13-6-14(13)19)17(23)21(10)9-11-3-2-4-12(18)5-11/h2-5,7-8,13-14H,6,9H2,1H3/t13?,14-/m0/s1 MVVQNOPLTGEXNR-KZUDCZAMSA-N 474153 7-(3-fluorobenzyl)-3-(cis-2- fluorocyclopropyl)-6- methylimidazo[1,5-a]pyrazin- 8(7H)-one, stereoisomer 1::US10858362, Example 37, isomer 1::US10912773, Example 38-isomer-1 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 149 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474153&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122663819 442074352 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998811 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)C1C[C@@H]1F InChI=1S/C17H15F2N3O/c1-10-8-22-15(7-20-16(22)13-6-14(13)19)17(23)21(10)9-11-3-2-4-12(18)5-11/h2-5,7-8,13-14H,6,9H2,1H3/t13?,14-/m0/s1 MVVQNOPLTGEXNR-KZUDCZAMSA-N 474153 7-(3-fluorobenzyl)-3-(cis-2- fluorocyclopropyl)-6- methylimidazo[1,5-a]pyrazin- 8(7H)-one, stereoisomer 1::US10858362, Example 37, isomer 1::US10912773, Example 38-isomer-1 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 582 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474153&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122663819 442074352 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998814 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)C1C[C@H]1F InChI=1S/C17H15F2N3O/c1-10-8-22-15(7-20-16(22)13-6-14(13)19)17(23)21(10)9-11-3-2-4-12(18)5-11/h2-5,7-8,13-14H,6,9H2,1H3/t13?,14-/m1/s1 MVVQNOPLTGEXNR-ARLHGKGLSA-N 481634 7-(3-fluorobenzyl)-3-(trans-2- methylimidazo[1,5-a]pyrazin- 8(7H)-one, stereoisomer 2::US10912773, Example 38-isomer-2 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 667 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=481634 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=481634&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122663820 443550807 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998817 Cc1cn2c(ncc2c(=O)n1Cc1ccc(OC2CC2)cc1)C1CCOCC1 InChI=1S/C22H25N3O3/c1-15-13-25-20(12-23-21(25)17-8-10-27-11-9-17)22(26)24(15)14-16-2-4-18(5-3-16)28-19-6-7-19/h2-5,12-13,17,19H,6-11,14H2,1H3 RVWGYNGTLDYNPU-UHFFFAOYSA-N 474157 7-(4-cyclopropoxybenzyl)-6- methyl-3-(tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 39::US10912773, Example 39::US11472810, Example 39 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 413 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474157&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652459 442074356 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998820 Cc1cn2c(ncc2c(=O)n1Cc1ccc(OC(F)F)cc1)C1CCOCC1 InChI=1S/C20H21F2N3O3/c1-13-11-25-17(10-23-18(25)15-6-8-27-9-7-15)19(26)24(13)12-14-2-4-16(5-3-14)28-20(21)22/h2-5,10-11,15,20H,6-9,12H2,1H3 QPWYRFGVZKZRGE-UHFFFAOYSA-N 474158 7-(4-(difluoromethoxy)benzyl)-6- methyl-3-(tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 40::US10912773, Example 40::US11472810, Example 40 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 73.0 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474158&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652417 442074357 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998823 Cc1cn2c(ncc2c(=O)n1Cc1ccc(OC(F)(F)F)cc1)C1CCOCC1 InChI=1S/C20H20F3N3O3/c1-13-11-26-17(10-24-18(26)15-6-8-28-9-7-15)19(27)25(13)12-14-2-4-16(5-3-14)29-20(21,22)23/h2-5,10-11,15H,6-9,12H2,1H3 UNRQWEFTRALILW-UHFFFAOYSA-N 474159 6-methyl-3-(tetrahydro-2H-pyran- 4-yl)-7-(4- (trifluoromethoxy)benzyl)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 41::US10912773, Example 41::US11472810, Example 41 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 27.0 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474159&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652254 442074358 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998827 CCc1cn2c(ncc2c(=O)n1Cc1ccccc1)C1CCOCC1 InChI=1S/C20H23N3O2/c1-2-17-14-23-18(12-21-19(23)16-8-10-25-11-9-16)20(24)22(17)13-15-6-4-3-5-7-15/h3-7,12,14,16H,2,8-11,13H2,1H3 LEQLMZLBAGAUDL-UHFFFAOYSA-N 474161 7-benzyl-6-ethyl-3-(tetrahydro- 2H-pyran-4-yl)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 43::US10912773, Example 43::US11472810, Example 43 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 105 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474161&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652424 442074360 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998830 CCc1cn2c(ncc2c(=O)n1Cc1ccc(OC)cc1)C1CCOCC1 InChI=1S/C21H25N3O3/c1-3-17-14-24-19(12-22-20(24)16-8-10-27-11-9-16)21(25)23(17)13-15-4-6-18(26-2)7-5-15/h4-7,12,14,16H,3,8-11,13H2,1-2H3 IHHHPGCUSMYQHX-UHFFFAOYSA-N 474162 6-ethyl-7-(4-methoxybenzyl)-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 44::US10912773, Example 44::US11472810, Example 44 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 40.0 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474162&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652232 442074361 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998833 Cc1cn2c(ncc2c(=O)n1Cc1cccc(c1)C#N)C1CCOCC1 InChI=1S/C20H20N4O2/c1-14-12-24-18(11-22-19(24)17-5-7-26-8-6-17)20(25)23(14)13-16-4-2-3-15(9-16)10-21/h2-4,9,11-12,17H,5-8,13H2,1H3 HBKUUJGKQVTMIE-UHFFFAOYSA-N 474163 3-((6-methyl-8-oxo-3-(tetrahydro- 2H-pyran-4-yl)imidazo[1,5- a]pyrazin-7(8H)- yl)methyl)benzonitrile::US10858362, Example 45::US10912773, Example 45::US11472810, Example 45 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2000 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474163&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652242 442074362 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998835 Cc1cn2c(ncc2c(=O)n1Cc1ccc(cc1)C#N)C1CCOCC1 InChI=1S/C20H20N4O2/c1-14-12-24-18(11-22-19(24)17-6-8-26-9-7-17)20(25)23(14)13-16-4-2-15(10-21)3-5-16/h2-5,11-12,17H,6-9,13H2,1H3 LQAZSSIUEDYCBP-UHFFFAOYSA-N 474164 4-((6-methyl-8-oxo-3-(tetrahydro- 2H-pyran-4-yl)imidazo[1,5- a]pyrazin-7(8H)- yl)methyl)benzonitrile::US10858362, Example 46::US10912773, Example 46::US11472810, Example 46 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 809 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474164&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652248 442074363 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998837 CCc1ccccc1Cn1c(C)cn2c(ncc2c1=O)C1CCOCC1 InChI=1S/C21H25N3O2/c1-3-16-6-4-5-7-18(16)14-23-15(2)13-24-19(21(23)25)12-22-20(24)17-8-10-26-11-9-17/h4-7,12-13,17H,3,8-11,14H2,1-2H3 HLXDXKMIVTXPEU-UHFFFAOYSA-N 474166 7-(2-ethylbenzyl)-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 49::US10912773, Example 49::US11472810, Example 49 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2000 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474166&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652447 442074365 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998839 Cc1cn2c(ncc2c(=O)n1Cc1ccc2OCOc2c1)C1CCOCC1 InChI=1S/C20H21N3O4/c1-13-10-23-16(9-21-19(23)15-4-6-25-7-5-15)20(24)22(13)11-14-2-3-17-18(8-14)27-12-26-17/h2-3,8-10,15H,4-7,11-12H2,1H3 ZABNCYCWYYVHOF-UHFFFAOYSA-N 474167 7-(benzo[d][1,3]dioxol-5- ylmethyl)-6-methyl-3-(tetrahydro- 2H-pyran-4-yl)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 50::US10912773, Example 50::US11472810, Example 50 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 50.0 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474167 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474167&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652367 442074366 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998842 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C2CCOCC2)cc1Cl InChI=1S/C20H22ClN3O3/c1-13-11-24-17(10-22-19(24)15-5-7-27-8-6-15)20(25)23(13)12-14-3-4-18(26-2)16(21)9-14/h3-4,9-11,15H,5-8,12H2,1-2H3 AKDKVOQBJMHADC-UHFFFAOYSA-N 474168 7-(3-chloro-4-methoxybenzyl)-6- methyl-3-(tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 51::US10912773, Example 51::US11472810, Example 51 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 199 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474168&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652468 442074367 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998846 Cc1cn2c(ncc2c(=O)n1Cc1ccc(O)cc1)C1CCOCC1 InChI=1S/C19H21N3O3/c1-13-11-22-17(10-20-18(22)15-6-8-25-9-7-15)19(24)21(13)12-14-2-4-16(23)5-3-14/h2-5,10-11,15,23H,6-9,12H2,1H3 HWZIGTUHYHCMIT-UHFFFAOYSA-N 474170 7-(4-hydroxybenzyl)-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 53::US10912773, Example 53::US11472810, Example 53 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 401 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474170&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652448 442074369 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998849 CCc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)C1CCOCC1 InChI=1S/C20H22FN3O2/c1-2-17-13-24-18(11-22-19(24)15-6-8-26-9-7-15)20(25)23(17)12-14-4-3-5-16(21)10-14/h3-5,10-11,13,15H,2,6-9,12H2,1H3 AFONMYZRPMFJAB-UHFFFAOYSA-N 474171 6-ethyl-7-(3-fluorobenzyl)-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 54::US10912773, Example 54::US11472810, Example 54 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 62.0 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474171&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652310 442074370 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998852 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)[C@@H]2CCO[C@@H]2C)cc1 InChI=1S/C20H23N3O3/c1-13-11-23-18(10-21-19(23)17-8-9-26-14(17)2)20(24)22(13)12-15-4-6-16(25-3)7-5-15/h4-7,10-11,14,17H,8-9,12H2,1-3H3/t14-,17-/m1/s1 PZHZVFDPQAUVKV-RHSMWYFYSA-N 474172 7-(4-methoxybenzyl)-6-methyl-3- (2-methyltetrahydrofuran-3- yl)imidazo[1,5-a]pyrazin-8(7H)- one, stereoisomer 1::US10858362, Example 55, isomer 1::US10912773, Example 55-isomer-1::US11472810, Example 55, isomer 1 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 20.0 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474172 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474172&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652364 442074371 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998855 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)[C@@H]2CCO[C@H]2C)cc1 InChI=1S/C20H23N3O3/c1-13-11-23-18(10-21-19(23)17-8-9-26-14(17)2)20(24)22(13)12-15-4-6-16(25-3)7-5-15/h4-7,10-11,14,17H,8-9,12H2,1-3H3/t14-,17+/m0/s1 PZHZVFDPQAUVKV-WMLDXEAASA-N 474173 7-(4-methoxybenzyl)-6-methyl-3- (2-methyltetrahydrofuran-3- yl)imidazo[1,5-a]pyrazin-8(7H)- one, stereoisomer 2::US10858362, Example 55, isomer 2::US10858362, Example 55, isomer 3::US10912773, Example 55-isomer-2::US11472810, Example 55, isomer 2 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 86.0 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474173&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652531 442074372 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998858 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)[C@H]2CCO[C@@H]2C)cc1 InChI=1S/C20H23N3O3/c1-13-11-23-18(10-21-19(23)17-8-9-26-14(17)2)20(24)22(13)12-15-4-6-16(25-3)7-5-15/h4-7,10-11,14,17H,8-9,12H2,1-3H3/t14-,17+/m1/s1 PZHZVFDPQAUVKV-PBHICJAKSA-N 480842 7-(4-methoxybenzyl)-6-methyl-3- yl)imidazo[1,5-a]pyrazin-8(7H)- one, stereoisomer 3::US10905688, Example 55, isomer 3::US11472810, Example 55, isomer 3 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 13.0 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=480842 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=480842&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652462 443550034 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998861 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C2CCOC2C)cc1 InChI=1S/C20H23N3O3/c1-13-11-23-18(10-21-19(23)17-8-9-26-14(17)2)20(24)22(13)12-15-4-6-16(25-3)7-5-15/h4-7,10-11,14,17H,8-9,12H2,1-3H3 PZHZVFDPQAUVKV-UHFFFAOYSA-N 481654 7-(4-methoxybenzyl)-6-methyl-3- yl)imidazo[1,5-a]pyrazin-8(7H)- one, stereoisomer 4::US10912773, Example 55-isomer-4 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 137 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=481654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=481654&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652472 443550827 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998864 CCCc1ncc2n1cc(C)n(Cc1ccc(OC)cc1)c2=O InChI=1S/C18H21N3O2/c1-4-5-17-19-10-16-18(22)20(13(2)11-21(16)17)12-14-6-8-15(23-3)9-7-14/h6-11H,4-5,12H2,1-3H3 YMHRUXWRFFVZTC-UHFFFAOYSA-N 474176 7-(4-methoxybenzyl)-6-methyl-3- propylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 56::US10912773, Example 56::US11472810, Example 56 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 65.0 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474176 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474176&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652426 442074374 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998867 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C2CCOCC2)cn1 InChI=1S/C19H22N4O3/c1-13-11-23-16(10-21-18(23)15-5-7-26-8-6-15)19(24)22(13)12-14-3-4-17(25-2)20-9-14/h3-4,9-11,15H,5-8,12H2,1-2H3 OVPVMIDVNMKKNU-UHFFFAOYSA-N 474177 7-((6-methoxypyridin-3- yl)methyl)-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 57::US10912773, Example 57::US11472810, Example 57 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 45.0 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474177 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474177&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652538 442074375 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998871 CCn1c(C)cn2c(ncc2c1=O)C1CCOCC1 InChI=1S/C14H19N3O2/c1-3-16-10(2)9-17-12(14(16)18)8-15-13(17)11-4-6-19-7-5-11/h8-9,11H,3-7H2,1-2H3 WESIRYTURBTMCP-UHFFFAOYSA-N 474179 7-ethyl-6-methyl-3-(tetrahydro- 2H-pyran-4-yl)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 59::US10912773, Example 59::US11472810, Example 59 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2333 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474179 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474179&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652457 442074377 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998874 CCCn1c(C)cn2c(ncc2c1=O)C1CCOCC1 InChI=1S/C15H21N3O2/c1-3-6-17-11(2)10-18-13(15(17)19)9-16-14(18)12-4-7-20-8-5-12/h9-10,12H,3-8H2,1-2H3 ARICWMJJQKCTDR-UHFFFAOYSA-N 474180 6-methyl-7-propyl-3-(tetrahydro- 2H-pyran-4-yl)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 60::US10912773, Example 60::US11472810, Example 60 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 810 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474180 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474180&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652455 442074378 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998877 CC(C)CCn1c(C)cn2c(ncc2c1=O)C1CCOCC1 InChI=1S/C17H25N3O2/c1-12(2)4-7-19-13(3)11-20-15(17(19)21)10-18-16(20)14-5-8-22-9-6-14/h10-12,14H,4-9H2,1-3H3 OEYDINZBWMRAIK-UHFFFAOYSA-N 474181 7-isopentyl-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 62::US10912773, Example 62::US11472810, Example 62 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1078 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474181&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652305 442074379 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998880 Cc1cn2c(ncc2c(=O)n1CC1CCCC1)C1CCOCC1 InChI=1S/C18H25N3O2/c1-13-11-21-16(10-19-17(21)15-6-8-23-9-7-15)18(22)20(13)12-14-4-2-3-5-14/h10-11,14-15H,2-9,12H2,1H3 IVIOKHSMYSCNPJ-UHFFFAOYSA-N 474182 7-(cyclopentylmethyl)-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 63::US10912773, Example 63::US11472810, Example 63 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 183 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474182 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474182&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652331 442074380 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998883 Cc1cn2c(ncc2c(=O)n1Cc1ccccc1C#N)C1CCOCC1 InChI=1S/C20H20N4O2/c1-14-12-24-18(11-22-19(24)15-6-8-26-9-7-15)20(25)23(14)13-17-5-3-2-4-16(17)10-21/h2-5,11-12,15H,6-9,13H2,1H3 ISOFGIBMBLOJRH-UHFFFAOYSA-N 474183 2-((6-methyl-8-oxo-3-(tetrahydro- 2H-pyran-4-yl)imidazo[1,5- a]pyrazin-7(8H)- yl)methyl)benzonitrile::US10858362, Example 64::US10912773, Example 64::US11472810, Example 64 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 624 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474183&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652237 442074381 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998886 Cc1cn2c(ncc2c(=O)n1CC1CCCCCC1)C1CCOCC1 InChI=1S/C20H29N3O2/c1-15-13-23-18(12-21-19(23)17-8-10-25-11-9-17)20(24)22(15)14-16-6-4-2-3-5-7-16/h12-13,16-17H,2-11,14H2,1H3 FIIDAEWKLGRESO-UHFFFAOYSA-N 474184 7-(cycloheptylmethyl)-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 65::US10912773, Example 65::US11472810, Example 65 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 10.00 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474184 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474184&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652324 442074382 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998889 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C2CCOCC2C)cc1 InChI=1S/C21H25N3O3/c1-14-13-27-9-8-18(14)20-22-10-19-21(25)23(15(2)11-24(19)20)12-16-4-6-17(26-3)7-5-16/h4-7,10-11,14,18H,8-9,12-13H2,1-3H3 YTOUKKHZMQVQLZ-UHFFFAOYSA-N 474189 7-(4-methoxybenzyl)-6-methyl-3- (3-methyltetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 69::US10912773, Example 69::US11472810, Example 69 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 13.0 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474189&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652323 442074386 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998892 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C2(C)CC3CCC2O3)cc1 InChI=1S/C22H25N3O3/c1-14-12-25-18(11-23-21(25)22(2)10-17-8-9-19(22)28-17)20(26)24(14)13-15-4-6-16(27-3)7-5-15/h4-7,11-12,17,19H,8-10,13H2,1-3H3 NRIDLTZEDZLZBY-UHFFFAOYSA-N 474190 7-(4-methoxybenzyl)-6-methyl-3- ((1R,2R,4S)-2-methyl-7- oxabicyclo[2.2.1]heptan-2- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 70::US10912773, Example 70::US11472810, Example 70 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 29.0 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474190 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474190&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122663821 442074387 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998895 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)[C@@H](C)c2ccccc2)cc1 InChI=1S/C23H23N3O2/c1-16-14-26-21(13-24-22(26)17(2)19-7-5-4-6-8-19)23(27)25(16)15-18-9-11-20(28-3)12-10-18/h4-14,17H,15H2,1-3H3/t17-/m0/s1 SWHFTCTZWOUUQD-KRWDZBQOSA-N 474191 (S)-7-(4-methoxybenzyl)-6- methyl-3-(1- phenylethyl)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 71::US10912773, Example 71::US11472810, Example 71 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 211 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474191 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474191&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652214 442074388 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998898 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)[C@H](C)c2ccccc2)cc1 InChI=1S/C23H23N3O2/c1-16-14-26-21(13-24-22(26)17(2)19-7-5-4-6-8-19)23(27)25(16)15-18-9-11-20(28-3)12-10-18/h4-14,17H,15H2,1-3H3/t17-/m1/s1 SWHFTCTZWOUUQD-QGZVFWFLSA-N 474192 (R)-7-(4-methoxybenzyl)-6- methyl-3-(1- phenylethyl)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 72::US10912773, Example 72::US11472810, Example 72 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 90.0 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474192&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652402 442074389 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998901 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C2(C)CCN(C)CC2)cc1 InChI=1S/C22H28N4O2/c1-16-14-26-19(13-23-21(26)22(2)9-11-24(3)12-10-22)20(27)25(16)15-17-5-7-18(28-4)8-6-17/h5-8,13-14H,9-12,15H2,1-4H3 UOMHYPRQAMXYDQ-UHFFFAOYSA-N 474193 3-(1,4-dimethylpiperidin-4-yl)-7- (4-methoxybenzyl)-6- methylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 73::US10912773, Example 73::US11472810, Example 73 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1923 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474193 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474193&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652233 442074390 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998904 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C2CCc3ccc(Cl)cc23)cc1 InChI=1S/C24H22ClN3O2/c1-15-13-28-22(24(29)27(15)14-16-3-8-19(30-2)9-4-16)12-26-23(28)20-10-6-17-5-7-18(25)11-21(17)20/h3-5,7-9,11-13,20H,6,10,14H2,1-2H3 COANVSPOSPBLGF-UHFFFAOYSA-N 474194 3-(6-chloro-2,3-dihydro-1H- inden-1-yl)-7-(4-methoxybenzyl)- 6-methylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 74::US10912773, Example 74::US11472810, Example 74 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 5.00 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474194 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474194&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652306 442074391 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998907 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C2(C)CNC(=O)C2)cc1 InChI=1S/C20H22N4O3/c1-13-10-24-16(9-21-19(24)20(2)8-17(25)22-12-20)18(26)23(13)11-14-4-6-15(27-3)7-5-14/h4-7,9-10H,8,11-12H2,1-3H3,(H,22,25) XKGOGXSNJQICIE-UHFFFAOYSA-N 474195 7-(4-methoxybenzyl)-6-methyl-3- (3-methyl-5-oxopyrrolidin-3- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 75::US10912773, Example 75::US11472810, Example 75 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 236 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474195&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652486 442074392 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998910 COCC(C)(C)c1ncc2n1cc(C)n(Cc1ccc(OC)cc1)c2=O InChI=1S/C20H25N3O3/c1-14-11-23-17(10-21-19(23)20(2,3)13-25-4)18(24)22(14)12-15-6-8-16(26-5)9-7-15/h6-11H,12-13H2,1-5H3 ANGLWHGRWFOZSQ-UHFFFAOYSA-N 474196 3-(1-methoxy-2-methylpropan-2- yl)-7-(4-methoxybenzyl)-6- methylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 76::US10912773, Example 76::US11472810, Example 76 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 122 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474196 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474196&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652293 442074393 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998913 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C(C)C)cc1 InChI=1S/C18H21N3O2/c1-12(2)17-19-9-16-18(22)20(13(3)10-21(16)17)11-14-5-7-15(23-4)8-6-14/h5-10,12H,11H2,1-4H3 RVHZRSIRMVWVKL-UHFFFAOYSA-N 474197 3-isopropyl-7-(4-methoxybenzyl)- 6-methylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 77::US10912773, Example 77::US11472810, Example 77 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 13.0 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474197 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474197&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652354 442074394 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998916 Cc1nc(Cn2c(C)cn3c(ncc3c2=O)C2CCOCC2)cs1 InChI=1S/C17H20N4O2S/c1-11-8-21-15(7-18-16(21)13-3-5-23-6-4-13)17(22)20(11)9-14-10-24-12(2)19-14/h7-8,10,13H,3-6,9H2,1-2H3 SFJUWCCYAPWXBB-UHFFFAOYSA-N 474198 6-methyl-7-((2-methylthiazol-4- yl)methyl)-3-(tetrahydro-2H- pyran-4-yl)imidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 78::US10912773, Example 78::US11472810, Example 78 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1691 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474198 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474198&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652259 442074395 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998919 Cc1cn2c(ncc2c(=O)n1Cc1cscn1)C1CCOCC1 InChI=1S/C16H18N4O2S/c1-11-7-20-14(6-17-15(20)12-2-4-22-5-3-12)16(21)19(11)8-13-9-23-10-18-13/h6-7,9-10,12H,2-5,8H2,1H3 SQDRHBKRJBDLOC-UHFFFAOYSA-N 474200 6-methyl-3-(tetrahydro-2H-pyran- 4-yl)-7-(thiazol-4- ylmethyl)imidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 80::US10912773, Example 80::US11472810, Example 80 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 228 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474200 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474200&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652330 442074397 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998927 Cc1cc(Cn2c(C)cn3c(ncc3c2=O)C2CCOCC2)on1 InChI=1S/C17H20N4O3/c1-11-7-14(24-19-11)10-20-12(2)9-21-15(17(20)22)8-18-16(21)13-3-5-23-6-4-13/h7-9,13H,3-6,10H2,1-2H3 ZKIKXHAKXUODEV-UHFFFAOYSA-N 474203 6-methyl-7-((3-methylisoxazol-5- yl)methyl)-3-(tetrahydro-2H- pyran-4-yl)imidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 83::US10912773, Example 83::US11472810, Example 83 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4444 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474203 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474203&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652332 442074400 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998930 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C2CC(C)OC(C)C2)cc1 InChI=1S/C22H27N3O3/c1-14-12-25-20(11-23-21(25)18-9-15(2)28-16(3)10-18)22(26)24(14)13-17-5-7-19(27-4)8-6-17/h5-8,11-12,15-16,18H,9-10,13H2,1-4H3 IJXXNTVMDPJVBW-UHFFFAOYSA-N 474204 3-(2,6-dimethyltetrahydro-2H- pyran-4-yl)-7-(4-methoxybenzyl)- 6-methylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 84::US10912773, Example 84::US11472810, Example 84 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 627 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474204 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474204&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652545 442074401 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998933 CCCc1ncc2n1cc(C)n(CC1CCCCC1)c2=O InChI=1S/C17H25N3O/c1-3-7-16-18-10-15-17(21)19(13(2)11-20(15)16)12-14-8-5-4-6-9-14/h10-11,14H,3-9,12H2,1-2H3 ZVDAZHCIEJDXMC-UHFFFAOYSA-N 474205 7-(cyclohexylmethyl)-6-methyl-3- propylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 85::US10912773, Example 85::US11472810, Example 85 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 120 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474205 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474205&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652381 442074402 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998936 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C(C)(C)O)cc1 InChI=1S/C18H21N3O3/c1-12-10-21-15(9-19-17(21)18(2,3)23)16(22)20(12)11-13-5-7-14(24-4)8-6-13/h5-10,23H,11H2,1-4H3 RVJAZKLTOAMCHB-UHFFFAOYSA-N 474206 3-(2-hydroxypropan-2-yl)-7-(4- methoxybenzyl)-6- methylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 86::US10912773, Example 86::US11472810, Example 86 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 193 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474206 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474206&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652382 442074403 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998939 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C(C)(C)F)cc1 InChI=1S/C18H20FN3O2/c1-12-10-22-15(9-20-17(22)18(2,3)19)16(23)21(12)11-13-5-7-14(24-4)8-6-13/h5-10H,11H2,1-4H3 DKRDXFRQADAIHU-UHFFFAOYSA-N 474207 3-(2-fluoropropan-2-yl)-7-(4- methoxybenzyl)-6- methylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 87::US10912773, Example 87::US11472810, Example 87 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 108 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474207 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474207&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652496 442074404 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998942 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C2CCNC(=O)CC2)cc1 InChI=1S/C21H24N4O3/c1-14-12-25-18(11-23-20(25)16-5-8-19(26)22-10-9-16)21(27)24(14)13-15-3-6-17(28-2)7-4-15/h3-4,6-7,11-12,16H,5,8-10,13H2,1-2H3,(H,22,26) ZMTDJXQCSYULBW-UHFFFAOYSA-N 474208 7-(4-methoxybenzyl)-6-methyl-3- (7-oxoazepan-4-yl)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 88::US10912773, Example 88::US11472810, Example 88 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 484 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474208&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652312 442074405 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998947 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C(C)c2nc(C)cs2)cc1 InChI=1S/C21H22N4O2S/c1-13-12-28-20(23-13)15(3)19-22-9-18-21(26)24(14(2)10-25(18)19)11-16-5-7-17(27-4)8-6-16/h5-10,12,15H,11H2,1-4H3 XRYJHUBBBIIQDO-UHFFFAOYSA-N 474210 7-(4-methoxybenzyl)-6-methyl-3- (1-(4-methylthiazol-2- yl)ethyl)imidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 90::US10912773, Example 90::US11472810, Example 90 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 34.0 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474210&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652338 442074407 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998950 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C2(C)CCN(C2)S(N)(=O)=O)cc1 InChI=1S/C20H25N5O4S/c1-14-11-25-17(18(26)24(14)12-15-4-6-16(29-3)7-5-15)10-22-19(25)20(2)8-9-23(13-20)30(21,27)28/h4-7,10-11H,8-9,12-13H2,1-3H3,(H2,21,27,28) RZZDUEKLZBHEJJ-UHFFFAOYSA-N 474211 3-(7-(4-methoxybenzyl)-6-methyl- 8-oxo-7,8-dihydroimidazo[1,5- a]pyrazin-3-yl)-3- methylpyrrolidine-1-sulfonamide::US10858362, Example 91::US10912773, Example 91::US11472810, Example 91 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 181 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474211 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474211&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652235 442074408 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998953 COc1ccc(Cn2c(CC3CCCC3)cn3c(ncc3c2=O)C2CCOCC2)cc1 InChI=1S/C25H31N3O3/c1-30-22-8-6-19(7-9-22)16-27-21(14-18-4-2-3-5-18)17-28-23(25(27)29)15-26-24(28)20-10-12-31-13-11-20/h6-9,15,17-18,20H,2-5,10-14,16H2,1H3 TUNXEGCQHJFZRL-UHFFFAOYSA-N 474212 6-(cyclopentylmethyl)-7-(4- methoxybenzyl)-3-(tetrahydro- 2H-pyran-4-yl)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 92::US10912773, Example 92::US11472810, Example 92 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 71.0 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474212 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474212&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652475 442074409 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998956 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)N2CCOCC2)cc1 InChI=1S/C19H22N4O3/c1-14-12-23-17(11-20-19(23)21-7-9-26-10-8-21)18(24)22(14)13-15-3-5-16(25-2)6-4-15/h3-6,11-12H,7-10,13H2,1-2H3 DRHDVSISCJNWFF-UHFFFAOYSA-N 474213 3-(morpholino)-7-(4- methoxybenzyl)-6- methylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 93::US10912773, Example 93::US11472810, Example 93 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 96.0 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474213&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652234 442074410 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998959 COc1ccc(Cn2c(C)cn3c(NC4CCOC4)ncc3c2=O)cc1 InChI=1S/C19H22N4O3/c1-13-10-23-17(9-20-19(23)21-15-7-8-26-12-15)18(24)22(13)11-14-3-5-16(25-2)6-4-14/h3-6,9-10,15H,7-8,11-12H2,1-2H3,(H,20,21) MVGJRDDRTHNROA-UHFFFAOYSA-N 474214 7-(4-methoxybenzyl)-6-methyl-3- ((tetrahydrofuran-3- yl)amino)imidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 94::US10912773, Example 94::US11472810, Example 94 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2516 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474214 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474214&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652491 442074411 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998962 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)N2CCOC[C@H]2C)cc1 InChI=1S/C20H24N4O3/c1-14-11-24-18(10-21-20(24)22-8-9-27-13-15(22)2)19(25)23(14)12-16-4-6-17(26-3)7-5-16/h4-7,10-11,15H,8-9,12-13H2,1-3H3/t15-/m1/s1 VQUWFLFKDYALSX-OAHLLOKOSA-N 474215 (R)-7-(4-methoxybenzyl)-6- methyl-3-(3- methylmorpholino)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 95::US10912773, Example 95::US11472810, Example 95 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 258 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474215 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474215&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652374 442074412 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 998965 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)N2CCOC[C@@H]2C)cc1 InChI=1S/C20H24N4O3/c1-14-11-24-18(10-21-20(24)22-8-9-27-13-15(22)2)19(25)23(14)12-16-4-6-17(26-3)7-5-16/h4-7,10-11,15H,8-9,12-13H2,1-3H3/t15-/m0/s1 VQUWFLFKDYALSX-HNNXBMFYSA-N 474216 (S)-7-(4-methoxybenzyl)-6- methyl-3-(3- methylmorpholino)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 96::US10912773, Example 96::US11472810, Example 96 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 48.0 US Patent 10.7270/Q2TF01FS aid1805235 US10912773 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474216&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652225 442074413 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1090296 O=c1n(CC2CCCCC2)c(Cc2ccccc2)nc2n(ncc12)C1CCOCC1 InChI=1S/C24H30N4O2/c29-24-21-16-25-28(20-11-13-30-14-12-20)23(21)26-22(15-18-7-3-1-4-8-18)27(24)17-19-9-5-2-6-10-19/h1,3-4,7-8,16,19-20H,2,5-6,9-15,17H2 YXOLEIZBMQWRJW-UHFFFAOYSA-N 517132 6-benzyl-5-(cyclohexylmethyl)-1- tetrahydropyran-4-yl-pyrazolo[3,4- d]pyrimidin-4-one::US11104680, Example 1 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 349 US Patent 10.7270/Q2765JGN aid1805893 US11104680 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Marigo, M; Kehler, J; Rasmussen, LK H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517132&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 131984828 461603175 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1090299 COc1ccc(Cn2c(C)nc3n(ncc3c2=O)C2CCOCC2)cc1 InChI=1S/C19H22N4O3/c1-13-21-18-17(11-20-23(18)15-7-9-26-10-8-15)19(24)22(13)12-14-3-5-16(25-2)6-4-14/h3-6,11,15H,7-10,12H2,1-2H3 IAAHGVIRZIKPHA-UHFFFAOYSA-N 517133 5-(4-methoxybenzyl)-6-methyl-1- (tetrahydro-2H-pyran-4-yl)-1H- pyrazolo[3,4-d]pyrimidin-4(5H)-one::US11104680, Example 2 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 132 US Patent 10.7270/Q2765JGN aid1805893 US11104680 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Marigo, M; Kehler, J; Rasmussen, LK H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517133&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 131984832 461603176 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1090302 Cc1nc2n(ncc2c(=O)n1CC1CCCCC1)C1CCOCC1 InChI=1S/C18H26N4O2/c1-13-20-17-16(11-19-22(17)15-7-9-24-10-8-15)18(23)21(13)12-14-5-3-2-4-6-14/h11,14-15H,2-10,12H2,1H3 FKFYCHHMKLLPQY-UHFFFAOYSA-N 517134 5-(cyclohexylmethyl)-6-methyl-1- tetrahydropyran-4-yl-pyrazolo[3,4- d]pyrimidin-4-one::US11104680, Example 3 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 172 US Patent 10.7270/Q2765JGN aid1805893 US11104680 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Marigo, M; Kehler, J; Rasmussen, LK H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517134&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 131984855 461603177 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1090305 CCCn1ncc2c1nc(C)n(Cc1ccc(OC)cc1)c2=O InChI=1S/C17H20N4O2/c1-4-9-21-16-15(10-18-21)17(22)20(12(2)19-16)11-13-5-7-14(23-3)8-6-13/h5-8,10H,4,9,11H2,1-3H3 PBXYUGSYGCBAKT-UHFFFAOYSA-N 517135 5-[(4-methoxyphenyl)methyl]-6- methyl-1-propyl-pyrazolo[3,4- d]pyrimidin-4-one::US11104680, Example 4 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 108 US Patent 10.7270/Q2765JGN aid1805893 US11104680 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Marigo, M; Kehler, J; Rasmussen, LK H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517135&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 131984830 461603178 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1090308 CCCn1ncc2c1nc(C)n(CC1CCCCC1)c2=O InChI=1S/C16H24N4O/c1-3-9-20-15-14(10-17-20)16(21)19(12(2)18-15)11-13-7-5-4-6-8-13/h10,13H,3-9,11H2,1-2H3 TYMBPQQASYCWEH-UHFFFAOYSA-N 517136 5-(cyclohexylmethyl)-6-methyl-1- propyl-pyrazolo[3,4-d]pyrimidin-4- one::US11104680, Example 5 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 111 US Patent 10.7270/Q2765JGN aid1805893 US11104680 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Marigo, M; Kehler, J; Rasmussen, LK H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517136&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 131984960 461603179 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1090311 CCc1nc2n(ncc2c(=O)n1Cc1ccc(OC)cc1)C1CCOCC1 InChI=1S/C20H24N4O3/c1-3-18-22-19-17(12-21-24(19)15-8-10-27-11-9-15)20(25)23(18)13-14-4-6-16(26-2)7-5-14/h4-7,12,15H,3,8-11,13H2,1-2H3 KVMXASWJIZJMBZ-UHFFFAOYSA-N 517137 6-ethyl-5-[(4-methoxyphenyl)methyl]- 1-tetrahydropyran-4-yl-pyrazolo[3,4- d]pyrimidin-4-one::US11104680, Example 6 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 107 US Patent 10.7270/Q2765JGN aid1805893 US11104680 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Marigo, M; Kehler, J; Rasmussen, LK H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517137&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 131984808 461603180 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1090314 COCc1nc2n(ncc2c(=O)n1Cc1ccc(OC)cc1)C1CCOCC1 InChI=1S/C20H24N4O4/c1-26-13-18-22-19-17(11-21-24(19)15-7-9-28-10-8-15)20(25)23(18)12-14-3-5-16(27-2)6-4-14/h3-6,11,15H,7-10,12-13H2,1-2H3 MZDJCPNZHVQURG-UHFFFAOYSA-N 517138 6-(methoxymethyl)-5-[(4- methoxyphenyl)methyl]-1- tetrahydropyran-4-yl-pyrazolo[3,4- d]pyrimidin-4-one::US11104680, Example 7 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 325 US Patent 10.7270/Q2765JGN aid1805893 US11104680 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Marigo, M; Kehler, J; Rasmussen, LK H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517138&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 131984864 461603181 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1090317 COc1ccc(Cn2c(nc3n(ncc3c2=O)C2CCOCC2)C(C)C)cc1 InChI=1S/C21H26N4O3/c1-14(2)19-23-20-18(12-22-25(20)16-8-10-28-11-9-16)21(26)24(19)13-15-4-6-17(27-3)7-5-15/h4-7,12,14,16H,8-11,13H2,1-3H3 IVICMAQJTMYPDI-UHFFFAOYSA-N 517139 6-isopropyl-5-[(4- methoxyphenyl)methyl]-1- tetrahydropyran-4-yl-pyrazolo[3,4- d]pyrimidin-4-one::US11104680, Example 8 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 751 US Patent 10.7270/Q2765JGN aid1805893 US11104680 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Marigo, M; Kehler, J; Rasmussen, LK H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517139&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 131984904 461603182 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1090322 Cc1nc2n(ncc2c(=O)n1Cc1cccc(F)c1)C1CCOCC1 InChI=1S/C18H19FN4O2/c1-12-21-17-16(10-20-23(17)15-5-7-25-8-6-15)18(24)22(12)11-13-3-2-4-14(19)9-13/h2-4,9-10,15H,5-8,11H2,1H3 VACQVANOFNLZEL-UHFFFAOYSA-N 517141 5-[(3-fluorophenyl)methyl]-6-methyl- 1-tetrahydropyran-4-yl-pyrazolo[4,3- c]pyridin-4-one::US11104680, Example 10 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1070 US Patent 10.7270/Q2765JGN aid1805893 US11104680 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Marigo, M; Kehler, J; Rasmussen, LK H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517141 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517141&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 153471531 461603184 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1090325 Cc1nc2n(ncc2c(=O)n1Cc1ccccc1F)C1CCOCC1 InChI=1S/C18H19FN4O2/c1-12-21-17-15(10-20-23(17)14-6-8-25-9-7-14)18(24)22(12)11-13-4-2-3-5-16(13)19/h2-5,10,14H,6-9,11H2,1H3 TXMZJMRBPNQFRI-UHFFFAOYSA-N 517142 5-[(2-fluorophenyl)methyl]-6-methyl- 1-tetrahydropyran-4-yl-pyrazolo[4,3- c]pyridin-4-one::US11104680, Example 11 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 589 US Patent 10.7270/Q2765JGN aid1805893 US11104680 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Marigo, M; Kehler, J; Rasmussen, LK H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517142&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 153471528 461603185 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1090328 Cc1nc2n(ncc2c(=O)n1Cc1ccc(Cl)cc1)C1CCOCC1 InChI=1S/C18H19ClN4O2/c1-12-21-17-16(10-20-23(17)15-6-8-25-9-7-15)18(24)22(12)11-13-2-4-14(19)5-3-13/h2-5,10,15H,6-9,11H2,1H3 ZILNXTHNKXUETP-UHFFFAOYSA-N 517143 5-[(4-chlorophenyl)methyl]-6-methyl- 1-tetrahydropyran-4-yl-pyrazolo[4,3- c]pyridin-4-one::US11104680, Example 12 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 127 US Patent 10.7270/Q2765JGN aid1805893 US11104680 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Marigo, M; Kehler, J; Rasmussen, LK H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517143 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517143&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 153471529 461603186 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1090331 Cc1nc2n(ncc2c(=O)n1Cc1ccccc1)C1CCOCC1 InChI=1S/C18H20N4O2/c1-13-20-17-16(11-19-22(17)15-7-9-24-10-8-15)18(23)21(13)12-14-5-3-2-4-6-14/h2-6,11,15H,7-10,12H2,1H3 WRYMSMMHCLFPFM-UHFFFAOYSA-N 517144 5-benzyl-6-methyl-1-tetrahydropyran-4-yl- pyrazolo[4,3-c]pyridin-4-one::US11104680, Example 13 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1264 US Patent 10.7270/Q2765JGN aid1805893 US11104680 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Marigo, M; Kehler, J; Rasmussen, LK H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517144&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 153471530 461603187 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1090334 Cc1cc2n(ncc2c(=O)n1Cc1cccc(Cl)c1)C1CCOCC1 InChI=1S/C19H20ClN3O2/c1-13-9-18-17(11-21-23(18)16-5-7-25-8-6-16)19(24)22(13)12-14-3-2-4-15(20)10-14/h2-4,9-11,16H,5-8,12H2,1H3 FZRPHLODQVQNHB-UHFFFAOYSA-N 517145 5-[(3-chlorophenyl)methyl]-6-methyl- 1-tetrahydropyran-4-yl-pyrazolo[4,3- c]pyridin-4-one::US11104680, Example 14 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1303 US Patent 10.7270/Q2765JGN aid1805893 US11104680 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Marigo, M; Kehler, J; Rasmussen, LK H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517145&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 131984823 461603188 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1090337 Cc1cc2n(ncc2c(=O)n1Cc1ccc(F)cc1)C1CCOCC1 InChI=1S/C19H20FN3O2/c1-13-10-18-17(11-21-23(18)16-6-8-25-9-7-16)19(24)22(13)12-14-2-4-15(20)5-3-14/h2-5,10-11,16H,6-9,12H2,1H3 LUDIBRFXTWLUSU-UHFFFAOYSA-N 517146 5-[(4-fluorophenyl)methyl]-6-methyl- 1-tetrahydropyran-4-yl-pyrazolo[4,3- c]pyridin-4-one::US11104680, Example 15 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1240 US Patent 10.7270/Q2765JGN aid1805893 US11104680 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Marigo, M; Kehler, J; Rasmussen, LK H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517146&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 131984840 461603189 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1090340 Cc1ccc(Cn2c(C)cc3n(ncc3c2=O)C2CCOCC2)cc1 InChI=1S/C20H23N3O2/c1-14-3-5-16(6-4-14)13-22-15(2)11-19-18(20(22)24)12-21-23(19)17-7-9-25-10-8-17/h3-6,11-12,17H,7-10,13H2,1-2H3 CXGGCYJPLGSTBH-UHFFFAOYSA-N 517147 6-methyl-5-(p-tolylmethyl)-1- tetrahydropyran-4-yl-pyrazolo[4,3- c]pyridin-4-one::US11104680, Example 16 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 400 US Patent 10.7270/Q2765JGN aid1805893 US11104680 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Marigo, M; Kehler, J; Rasmussen, LK H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517147&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 131984836 461603190 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1090343 Cc1cc2n(ncc2c(=O)n1Cc1ccc2OCOc2c1)C1CCOCC1 InChI=1S/C20H21N3O4/c1-13-8-17-16(10-21-23(17)15-4-6-25-7-5-15)20(24)22(13)11-14-2-3-18-19(9-14)27-12-26-18/h2-3,8-10,15H,4-7,11-12H2,1H3 APQLMNUUGPWXRZ-UHFFFAOYSA-N 517148 5-(1,3-benzodioxol-5-ylmethyl)-6- methyl-1-tetrahydropyran-4-yl- pyrazolo[4,3-c]pyridin-4-one::US11104680, Example 17 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 429 US Patent 10.7270/Q2765JGN aid1805893 US11104680 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Marigo, M; Kehler, J; Rasmussen, LK H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517148&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 131984905 461603191 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1090346 COc1ccc(Cn2c(C)cc3n(ncc3c2=O)C2CCOCC2)cc1 InChI=1S/C20H23N3O3/c1-14-11-19-18(12-21-23(19)16-7-9-26-10-8-16)20(24)22(14)13-15-3-5-17(25-2)6-4-15/h3-6,11-12,16H,7-10,13H2,1-2H3 LWAQPJWARNOJEY-UHFFFAOYSA-N 517149 5-[(6-methoxy-3-pyridyl)methyl]-6- methyl-1-tetrahydropyran-4-yl- pyrazolo[4,3-c]pyridin-4-one::US11104680, Example 18::US11104680, Example 19::US11104680, Example 25 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 738 US Patent 10.7270/Q2765JGN aid1805893 US11104680 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Marigo, M; Kehler, J; Rasmussen, LK H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517149&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 131984861 461603192 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1090349 COc1ccc(Cn2c(C)cc3n(ncc3c2=O)C2CCOCC2)cc1 InChI=1S/C20H23N3O3/c1-14-11-19-18(12-21-23(19)16-7-9-26-10-8-16)20(24)22(14)13-15-3-5-17(25-2)6-4-15/h3-6,11-12,16H,7-10,13H2,1-2H3 LWAQPJWARNOJEY-UHFFFAOYSA-N 517149 5-[(6-methoxy-3-pyridyl)methyl]-6- methyl-1-tetrahydropyran-4-yl- pyrazolo[4,3-c]pyridin-4-one::US11104680, Example 18::US11104680, Example 19::US11104680, Example 25 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 184 US Patent 10.7270/Q2765JGN aid1805893 US11104680 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Marigo, M; Kehler, J; Rasmussen, LK H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517149&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 131984861 461603192 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1090352 CCCn1ncc2c1cc(C)n(Cc1ccc(OC)cc1)c2=O InChI=1S/C18H21N3O2/c1-4-9-21-17-10-13(2)20(18(22)16(17)11-19-21)12-14-5-7-15(23-3)8-6-14/h5-8,10-11H,4,9,12H2,1-3H3 GMPCYHZOARRAOF-UHFFFAOYSA-N 517151 5-(4-methoxybenzyl)-6-methyl-1- propyl-1,5-dihydro-4H-pyrazolo[4,3- c]pyridin-4-one::US11104680, Example 20 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 290 US Patent 10.7270/Q2765JGN aid1805893 US11104680 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Marigo, M; Kehler, J; Rasmussen, LK H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517151 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517151&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 131984825 461603193 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1090355 COc1ccc(Cn2c(C)cc3n(ncc3c2=O)C(C)C)cc1 InChI=1S/C18H21N3O2/c1-12(2)21-17-9-13(3)20(18(22)16(17)10-19-21)11-14-5-7-15(23-4)8-6-14/h5-10,12H,11H2,1-4H3 LCELOTJXOWMXKN-UHFFFAOYSA-N 517155 1-isopropyl-5-[(4- methoxyphenyl)methyl]-6-methyl- pyrazolo[4,3-c]pyridin-4-one::US11104680, Example 21 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 49.0 US Patent 10.7270/Q2765JGN aid1805893 US11104680 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Marigo, M; Kehler, J; Rasmussen, LK H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517155&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 131984819 461603197 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1090358 COc1ccc(Cn2c(C)cc3n(ncc3c2=O)C2CCOC2)cc1 InChI=1S/C19H21N3O3/c1-13-9-18-17(10-20-22(18)15-7-8-25-12-15)19(23)21(13)11-14-3-5-16(24-2)6-4-14/h3-6,9-10,15H,7-8,11-12H2,1-2H3 VJXIKYZGNVVTHA-UHFFFAOYSA-N 517158 5-[(4-methoxyphenyl)methyl]-6- methyl-1-tetrahydrofuran-3-yl- pyrazolo[4,3-c]pyridin-4-one::US11104680, Example 22 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1691 US Patent 10.7270/Q2765JGN aid1805893 US11104680 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Marigo, M; Kehler, J; Rasmussen, LK H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517158&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 131984959 461603200 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1090361 COc1ccc(Cn2c(C)cc3n(ncc3c2=O)C2CC2)cc1 InChI=1S/C18H19N3O2/c1-12-9-17-16(10-19-21(17)14-5-6-14)18(22)20(12)11-13-3-7-15(23-2)8-4-13/h3-4,7-10,14H,5-6,11H2,1-2H3 RQVFLKLHPKLTIO-UHFFFAOYSA-N 517159 1-cyclopropyl-5-[(4- methoxyphenyl)methyl]-6-methyl- pyrazolo[4,3-c]pyridin-4-one::US11104680, Example 23 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 543 US Patent 10.7270/Q2765JGN aid1805893 US11104680 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Marigo, M; Kehler, J; Rasmussen, LK H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517159&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 131984846 461603201 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1090364 CCn1ncc2c1cc(C)n(Cc1ccc(OC)cc1)c2=O InChI=1S/C17H19N3O2/c1-4-20-16-9-12(2)19(17(21)15(16)10-18-20)11-13-5-7-14(22-3)8-6-13/h5-10H,4,11H2,1-3H3 LZTQRMBMZGEDRE-UHFFFAOYSA-N 517161 1-ethyl-5-[(4-methoxyphenyl)methyl]- 6-methyl-pyrazolo[4,3-c]pyridin-4- one::US11104680, Example 24 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1115 US Patent 10.7270/Q2765JGN aid1805893 US11104680 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Marigo, M; Kehler, J; Rasmussen, LK H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517161&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 131984818 461603203 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1090367 COc1ccc(Cn2c(C)cc3n(ncc3c2=O)C2CCOCC2)cc1 InChI=1S/C20H23N3O3/c1-14-11-19-18(12-21-23(19)16-7-9-26-10-8-16)20(24)22(14)13-15-3-5-17(25-2)6-4-15/h3-6,11-12,16H,7-10,13H2,1-2H3 LWAQPJWARNOJEY-UHFFFAOYSA-N 517149 5-[(6-methoxy-3-pyridyl)methyl]-6- methyl-1-tetrahydropyran-4-yl- pyrazolo[4,3-c]pyridin-4-one::US11104680, Example 18::US11104680, Example 19::US11104680, Example 25 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 825 US Patent 10.7270/Q2765JGN aid1805893 US11104680 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Marigo, M; Kehler, J; Rasmussen, LK H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517149&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 131984861 461603192 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1090370 COc1ccc(Cn2c(C)cc3n(ncc3c2=O)C2CCO[C@H]2C)cc1 InChI=1S/C20H23N3O3/c1-13-10-19-17(11-21-23(19)18-8-9-26-14(18)2)20(24)22(13)12-15-4-6-16(25-3)7-5-15/h4-7,10-11,14,18H,8-9,12H2,1-3H3/t14-,18?/m0/s1 SBPLRPBAFIENJD-PIVQAISJSA-N 517163 5-[(4-methoxyphenyl)methyl]-6- methyl-1-[(2S,3R)-2- methyltetrahydrofuran-3- yl]pyrazolo[4,3-c]pyridin-4-one::US11104680, Example 26 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 206 US Patent 10.7270/Q2765JGN aid1805893 US11104680 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Marigo, M; Kehler, J; Rasmussen, LK H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517163&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 131997434 461603204 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1090373 COc1ccc(Cn2c(C)cc3n(ncc3c2=O)C2CCO[C@@H]2C)cc1 InChI=1S/C20H23N3O3/c1-13-10-19-17(11-21-23(19)18-8-9-26-14(18)2)20(24)22(13)12-15-4-6-16(25-3)7-5-15/h4-7,10-11,14,18H,8-9,12H2,1-3H3/t14-,18?/m1/s1 SBPLRPBAFIENJD-IKJXHCRLSA-N 517164 5-[(4-methoxyphenyl)methyl]-6- methyl-1-[(2R,3R)-2- methyltetrahydrofuran-3- yl]pyrazolo[4,3-c]pyridin-4-one::US11104680, Example 27 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1303 US Patent 10.7270/Q2765JGN aid1805893 US11104680 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Marigo, M; Kehler, J; Rasmussen, LK H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517164&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 131997435 461603205 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1090378 COc1ccc(Cn2c(C)cc3n(ncc3c2=O)C2(C)CCOCC2)cc1 InChI=1S/C21H25N3O3/c1-15-12-19-18(13-22-24(19)21(2)8-10-27-11-9-21)20(25)23(15)14-16-4-6-17(26-3)7-5-16/h4-7,12-13H,8-11,14H2,1-3H3 VWDZYEFJJSYZME-UHFFFAOYSA-N 517166 5-(4-methoxybenzyl)-6-methyl-1-(4- methyltetrahydro-2H-pyran-4-yl)-1,5- dihydro-4H-pyrazolo[4,3-c]pyridin-4- one::US11104680, Example 29 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 119 US Patent 10.7270/Q2765JGN aid1805893 US11104680 Juhl, K; Jessing, M; Langgard, M; Vital, PJ; Marigo, M; Kehler, J; Rasmussen, LK H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=517166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=517166&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 131984824 461603207 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044727 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C1CC1 InChI=1S/C22H25N7O/c1-4-30-22-17(6-5-9-23-22)18-10-19(24-11-15-12-25-28(3)13-15)21-20(26-18)14(2)27-29(21)16-7-8-16/h5-6,9-10,12-13,16H,4,7-8,11H2,1-3H3,(H,24,26) SVNBZNOJEMDHHP-UHFFFAOYSA-N 278982 1-cyclopropyl-5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 12::US10512632, Example 12::US10618913, Example S12::US10766893, Example S12::US10806718, Example 12::US11026923, Example 12::US11491140, Example 12 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 200 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278982&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273311 378160571 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044730 CCCn1ncc2nc(cc(NCc3cnn(C)c3)c12)-c1cccnc1OCC InChI=1S/C21H25N7O/c1-4-9-28-20-18(23-11-15-12-24-27(3)14-15)10-17(26-19(20)13-25-28)16-7-6-8-22-21(16)29-5-2/h6-8,10,12-14H,4-5,9,11H2,1-3H3,(H,23,26) VBBYLKGVLRZVDT-UHFFFAOYSA-N 278983 5-(2-ethoxy-3-pyridyl)-N-[(1-methylpyrazol-4-yl)methyl]-1-propyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 13::US10512632, Example 13::US10618913, Example S13::US10766893, Example S13::US10806718, Example 13::US11026923, Example 13::US11491140, Example 13::US11634416, Example 13 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 90.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278983 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278983&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273312 378160572 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044733 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(ncc2n1)C1COC1 InChI=1S/C21H23N7O2/c1-3-30-21-16(5-4-6-22-21)17-7-18(23-8-14-9-24-27(2)11-14)20-19(26-17)10-25-28(20)15-12-29-13-15/h4-7,9-11,15H,3,8,12-13H2,1-2H3,(H,23,26) BRAWZTIBDHEBNS-UHFFFAOYSA-N 278984 5-(2-ethoxypyridin-3-yl)-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1-(oxetan-3-yl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 14::US10512632, Example 14::US10618913, Example S14::US10766893, Example S14::US10806718, Example 14::US11026923, Example 14::US11491140, Example 14::US11634416, Example 14 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 450 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278984 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278984&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273313 378160573 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044736 CCOc1ncccc1-c1cc(NC(C)c2cnn(C)c2)c2n(C)ncc2n1 InChI=1S/C20H23N7O/c1-5-28-20-15(7-6-8-21-20)16-9-17(19-18(25-16)11-23-27(19)4)24-13(2)14-10-22-26(3)12-14/h6-13H,5H2,1-4H3,(H,24,25) PRZKTPKTSVRPRD-UHFFFAOYSA-N 278985 5-(2-ethoxypyridin-3-yl)-1-methyl-N-(1-(1-methyl-1H-pyrazol-4-yl)ethyl)-1H-pyrazolo[4,3-b]pyridin-7-amine (racemic)::US10034861, Example 15::US10766893, Example S15::US10806718, Example 15::US11026923, Example 15::US11491140, Example 15 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 820 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278985 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278985&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273314 378160574 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044739 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(C)ncc2n1 InChI=1S/C19H21N7O/c1-4-27-19-14(6-5-7-20-19)15-8-16(18-17(24-15)11-23-26(18)3)21-9-13-10-22-25(2)12-13/h5-8,10-12H,4,9H2,1-3H3,(H,21,24) IHPVHEUBCHVJEQ-UHFFFAOYSA-N 278986 5-(2-ethoxypyridin-3-yl)-1-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 16::US10512632, Example 16::US10766893, Example S16::US10806718, Example 16::US11026923, Example 16::US11491140, Example 16 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 670 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278986&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273315 378160575 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044742 CCOc1ncccc1-c1cc(NCc2nccn2C)c2n(ncc2n1)C(C)C InChI=1S/C21H25N7O/c1-5-29-21-15(7-6-8-23-21)16-11-17(24-13-19-22-9-10-27(19)4)20-18(26-16)12-25-28(20)14(2)3/h6-12,14H,5,13H2,1-4H3,(H,24,26) XRIYYPDCPKIHRW-UHFFFAOYSA-N 278987 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimidazol-2-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 17::US10512632, Example 17::US10618913, Example S17::US10766893, Example S17::US10806718, Example 17::US11026923, Example 17::US11491140, Example 17::US11634416, Example 17 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 700 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278987 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278987&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273316 378160576 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044745 CCOc1ncccc1-c1cc(NCc2ccnn2C)c2n(ncc2n1)C(C)C InChI=1S/C21H25N7O/c1-5-29-21-16(7-6-9-22-21)17-11-18(23-12-15-8-10-24-27(15)4)20-19(26-17)13-25-28(20)14(2)3/h6-11,13-14H,5,12H2,1-4H3,(H,23,26) ARZYUJKMHFQSRW-UHFFFAOYSA-N 278988 5-(2-ethoxypyridin-3-yl)-1-isopropyl-N-((1-methyl-1H-pyrazol-5-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 18::US10512632, Example 18::US10766893, Example S18::US10806718, Example 18::US11026923, Example 18::US11491140, Example 18::US11634416, Example 18 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 450 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278988&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273317 378160577 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044748 CCOc1ncccc1-c1cc(NCc2ccn(C)n2)c2n(ncc2n1)C(C)C InChI=1S/C21H25N7O/c1-5-29-21-16(7-6-9-22-21)17-11-18(23-12-15-8-10-27(4)26-15)20-19(25-17)13-24-28(20)14(2)3/h6-11,13-14H,5,12H2,1-4H3,(H,23,25) KZFYUJZMDBTCDC-UHFFFAOYSA-N 278989 5-(2-ethoxypyridin-3-yl)-1-isopropyl-N-((1-methyl-1H-pyrazol-3-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 19::US10512632, Example 19::US10766893, Example S19::US10806718, Example 19::US11026923, Example 19::US11491140, Example 19::US11634416, Example 19 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 66.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278989 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278989&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273318 378160578 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044751 CCOc1ncccc1-c1cc(NCc2nccs2)c2n(ncc2n1)C(C)C InChI=1S/C20H22N6OS/c1-4-27-20-14(6-5-7-22-20)15-10-16(23-12-18-21-8-9-28-18)19-17(25-15)11-24-26(19)13(2)3/h5-11,13H,4,12H2,1-3H3,(H,23,25) ICTYYJZHJNSZFG-UHFFFAOYSA-N 278990 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-(thiazol-2-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 20::US10512632, Example 20::US10766893, Example S20::US10806718, Example 20::US11026923, Example 20::US11491140, Example 20::US11634416, Example 20 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 520 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278990&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273319 378160579 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044754 CCOc1ncccc1-c1cc(NCc2cn(C)cn2)c2n(ncc2n1)C(C)C InChI=1S/C21H25N7O/c1-5-29-21-16(7-6-8-22-21)17-9-18(23-10-15-12-27(4)13-24-15)20-19(26-17)11-25-28(20)14(2)3/h6-9,11-14H,5,10H2,1-4H3,(H,23,26) GPZPPQFWVLHHBU-UHFFFAOYSA-N 278991 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimidazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 21::US10512632, Example 21::US10766893, Example S21::US10806718, Example 21::US11026923, Example 21::US11491140, Example 21::US11634416, Example 21 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.90 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278991&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273320 378160580 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044757 CCOc1ncccc1-c1cc(NCc2ccncc2)c2n(ncc2n1)C(C)C InChI=1S/C22H24N6O/c1-4-29-22-17(6-5-9-24-22)18-12-19(25-13-16-7-10-23-11-8-16)21-20(27-18)14-26-28(21)15(2)3/h5-12,14-15H,4,13H2,1-3H3,(H,25,27) HEERUKANWGHTOL-UHFFFAOYSA-N 278992 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-(4-pyridylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 22::US10512632, Example 22::US10766893, Example S22::US10806718, Example 22::US11026923, Example 22::US11491140, Example 22::US11634416, Example 22 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 250 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278992&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273322 378160581 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044760 CCOc1ncccc1-c1cc(NCc2cccc(C)c2)c2n(ncc2n1)C(C)C InChI=1S/C24H27N5O/c1-5-30-24-19(10-7-11-25-24)20-13-21(26-14-18-9-6-8-17(4)12-18)23-22(28-20)15-27-29(23)16(2)3/h6-13,15-16H,5,14H2,1-4H3,(H,26,28) NOGPVEPEDSPNHF-UHFFFAOYSA-N 278993 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-(m-tolylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 23::US10512632, Example 23::US10618913, Example S23::US10766893, Example S23::US10806718, Example 23::US11026923, Example 23::US11491140, Example 23::US11634416, Example 23 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 240 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278993&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273321 378160582 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044763 CCOc1ncccc1-c1cc(NCc2ccc(C)cc2)c2n(ncc2n1)C(C)C InChI=1S/C24H27N5O/c1-5-30-24-19(7-6-12-25-24)20-13-21(26-14-18-10-8-17(4)9-11-18)23-22(28-20)15-27-29(23)16(2)3/h6-13,15-16H,5,14H2,1-4H3,(H,26,28) KLXXAXDPPNWJOU-UHFFFAOYSA-N 278994 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-(p-tolylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 24::US10512632, Example 24::US10766893, Example S24::US10806718, Example 24::US11026923, Example 24::US11491140, Example 24::US11634416, Example 24 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 380 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278994&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273323 378160583 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044766 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(ncc2n1)C(C)C InChI=1S/C21H25N7O/c1-5-29-21-16(7-6-8-22-21)17-9-18(23-10-15-11-24-27(4)13-15)20-19(26-17)12-25-28(20)14(2)3/h6-9,11-14H,5,10H2,1-4H3,(H,23,26) PLERDTYSXFBCOL-UHFFFAOYSA-N 278995 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 25::US10512632, Example 25::US10766893, Example S25::US10806718, Example 25::US11026923, Example 25::US11491140, Example 25::US11634416, Example 25 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 56.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278995&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273324 378160584 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044769 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(CC)ncc2n1 InChI=1S/C20H23N7O/c1-4-27-19-17(22-10-14-11-23-26(3)13-14)9-16(25-18(19)12-24-27)15-7-6-8-21-20(15)28-5-2/h6-9,11-13H,4-5,10H2,1-3H3,(H,22,25) GDQVLYVPAWKIKI-UHFFFAOYSA-N 424936 US10512632, Example 26::US10618913, Example S26::US10766893, Example S26::US10806718, Example 26::US11026923, Example 26::US11491140, Example 26::US11634416, Example 26 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 140 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=424936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=424936&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138536209 434150491 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044772 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C1COC1 InChI=1S/C22H25N7O2/c1-4-31-22-17(6-5-7-23-22)18-8-19(24-9-15-10-25-28(3)11-15)21-20(26-18)14(2)27-29(21)16-12-30-13-16/h5-8,10-11,16H,4,9,12-13H2,1-3H3,(H,24,26) HKTCICUQHUTDJM-UHFFFAOYSA-N 278997 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-1-(oxetan-3-yl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 27::US10512632, Example 27::US10766893, Example S27::US10806718, Example 27::US11026923, Example 27::US11491140, Example 27::US11634416, Example 27 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 94.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278997 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278997&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273326 378160586 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044775 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(C)nc(C)c2n1 InChI=1S/C20H23N7O/c1-5-28-20-15(7-6-8-21-20)16-9-17(22-10-14-11-23-26(3)12-14)19-18(24-16)13(2)25-27(19)4/h6-9,11-12H,5,10H2,1-4H3,(H,22,24) GGQMHLLGYDUHDQ-UHFFFAOYSA-N 278998 5-(2-ethoxy-3-pyridyl)-1,3-dimethyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 28::US10512632, Example 28::US10618913, Example S28::US10766893, Example S28::US10806718, Example 28::US11026923, Example 28::US11491140, Example 28::US11634416, Example 28 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 550 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278998 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278998&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273327 378160587 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044778 CCOc1ncccc1-c1cc(NCc2nc(C)cs2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6OS/c1-6-29-22-16(8-7-9-23-22)17-10-18(24-11-19-25-14(4)12-30-19)21-20(26-17)15(5)27-28(21)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,24,26) WFSFSRAGPIZNCC-UHFFFAOYSA-N 278999 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(4-methylthiazol-2-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 29::US10512632, Example 29::US10618913, Example S162::US10766893, Example S29::US10806718, Example 29::US11026923, Example 29::US11491140, Example 29::US11634416, Example 29 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 27.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278999 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278999&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273328 378160588 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044781 CCOc1ncccc1-c1cc(NCc2nc(C)no2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H25N7O2/c1-6-29-21-15(8-7-9-22-21)16-10-17(23-11-18-24-14(5)27-30-18)20-19(25-16)13(4)26-28(20)12(2)3/h7-10,12H,6,11H2,1-5H3,(H,23,25) ZPMKSBYSMXCOIZ-UHFFFAOYSA-N 279000 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(3-methyl-1,2,4-oxadiazol-5-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 30::US10512632, Example 30::US10766893, Example S30::US10806718, Example 30::US11026923, Example 30::US11491140, Example 30::US11634416, Example 30 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 15.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279000 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279000&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273329 378160589 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044784 CCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-6-30-21-15(8-7-9-22-21)16-10-17(23-11-18-24-12-28(5)27-18)20-19(25-16)14(4)26-29(20)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,23,25) CJOUFKUESMXTOX-UHFFFAOYSA-N 279001 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 161::US10034861, Example 31::US10512632, Example 31::US10766893, Example S31::US10806718, Example 31::US11026923, Example 31::US11491140, Example 31::US11634416, Example 31 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.20 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279001 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279001&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273330 378160590 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044787 CCOc1ncccc1-c1cc(NCc2cnc(C)s2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6OS/c1-6-29-22-17(8-7-9-23-22)18-10-19(25-12-16-11-24-15(5)30-16)21-20(26-18)14(4)27-28(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,25,26) UJFBEAPRUYBIKE-UHFFFAOYSA-N 279002 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methylthiazol-5-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 32::US10512632, Example 32::US10766893, Example S32::US10806718, Example 32::US11026923, Example 32::US11491140, Example 32::US11634416, Example 32 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4.60 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279002&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273331 378160591 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044790 CCOc1ncccc1-c1cc(NCc2nnc(C)s2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H25N7OS/c1-6-29-21-15(8-7-9-22-21)16-10-17(23-11-18-26-25-14(5)30-18)20-19(24-16)13(4)27-28(20)12(2)3/h7-10,12H,6,11H2,1-5H3,(H,23,24) XQUFGMNXDPCXMM-UHFFFAOYSA-N 279003 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methyl-1,3,4-thiadiazol-2-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 33::US10512632, Example 33::US10766893, Example S33::US10806718, Example 33::US11026923, Example 33::US11491140, Example 33::US11634416, Example 33 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.60 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279003 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279003&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273332 378160592 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044793 CCOc1ncccc1-c1cc(NCc2csc(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N5OS/c1-6-29-23-18(8-7-9-24-23)19-11-20(25-12-17-10-15(4)30-13-17)22-21(26-19)16(5)27-28(22)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,25,26) VNCLCBKVWWHCAF-UHFFFAOYSA-N 279004 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methyl-3-thienyl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 34::US10512632, Example 34::US10766893, Example S34::US10806718, Example 34::US11026923, Example 34::US11491140, Example 34::US11634416, Example 34 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.10 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279004 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279004&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273333 378160593 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044796 CCOc1ncccc1-c1cc(NCc2cc(C)cs2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N5OS/c1-6-29-23-18(8-7-9-24-23)19-11-20(25-12-17-10-15(4)13-30-17)22-21(26-19)16(5)27-28(22)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,25,26) DHODKXCCORNYHA-UHFFFAOYSA-N 279005 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(4-methyl-2-thienyl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 35::US10512632, Example 35::US10766893, Example S35::US10806718, Example 35::US11026923, Example 35::US11491140, Example 35::US11634416, Example 35 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 7.30 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279005 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279005&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273334 378160594 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044799 CCOc1ncccc1-c1cc(NCc2ccc(C)s2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N5OS/c1-6-29-23-18(8-7-11-24-23)19-12-20(25-13-17-10-9-15(4)30-17)22-21(26-19)16(5)27-28(22)14(2)3/h7-12,14H,6,13H2,1-5H3,(H,25,26) MXNGXYQZCMFPJD-UHFFFAOYSA-N 279006 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methyl-2-thienyl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 36::US10512632, Example 36::US10766893, Example S36::US10806718, Example 36::US11026923, Example 36::US11491140, Example 36::US11634416, Example 36 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 24.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279006&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273337 378160595 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044802 CCOc1ncccc1-c1cc(NCc2coc(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6O2/c1-6-29-22-17(8-7-9-23-22)18-10-19(24-11-16-12-30-15(5)25-16)21-20(26-18)14(4)27-28(21)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,24,26) VZTGUNQMZSOPTA-UHFFFAOYSA-N 279007 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methyloxazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 37::US10512632, Example 37::US10766893, Example S37::US10806718, Example 37::US11026923, Example 37::US11491140, Example 37::US11634416, Example 37 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 5.90 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279007 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279007&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273335 378160596 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044805 CCOc1ncccc1-c1cc(NCc2ncc(C)o2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6O2/c1-6-29-22-16(8-7-9-23-22)17-10-18(24-12-19-25-11-14(4)30-19)21-20(26-17)15(5)27-28(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,24,26) IGMSFVIKHQRGSP-UHFFFAOYSA-N 279008 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methyloxazol-2-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 38::US10512632, Example 38::US10766893, Example S38::US10806718, Example 38::US11026923, Example 38::US11491140, Example 38::US11634416, Example 38 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.10 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279008 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279008&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273338 378160597 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044808 CCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H25N7O/c1-5-29-21-16(7-6-9-22-21)17-11-18(23-12-15-8-10-24-26-15)20-19(25-17)14(4)27-28(20)13(2)3/h6-11,13H,5,12H2,1-4H3,(H,23,25)(H,24,26) UOWVOVPKNPTQQH-UHFFFAOYSA-N 279009 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 39::US10512632, Example 39::US10766893, Example S39::US10806718, Example 39::US11026923, Example 39::US11491140, Example 39::US11634416, Example 39 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.10 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279009 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279009&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273340 378160598 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044811 CCOc1ncccc1-c1cc(NCc2c[nH]cn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H25N7O/c1-5-29-21-16(7-6-8-23-21)17-9-18(24-11-15-10-22-12-25-15)20-19(26-17)14(4)27-28(20)13(2)3/h6-10,12-13H,5,11H2,1-4H3,(H,22,25)(H,24,26) IQIUSKXHLPBBOV-UHFFFAOYSA-N 279010 5-(2-ethoxy-3-pyridyl)-N-(1H-imidazol-4-ylmethyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 40::US10512632, Example 40::US10766893, Example S40::US10806718, Example 40::US11026923, Example 40::US11491140, Example 40::US11634416, Example 40 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 14.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279010 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279010&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273339 378160599 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044814 CCOc1ncccc1-c1cc(NCc2ccccc2)c2n(ncc2n1)C(C)C InChI=1S/C23H25N5O/c1-4-29-23-18(11-8-12-24-23)19-13-20(25-14-17-9-6-5-7-10-17)22-21(27-19)15-26-28(22)16(2)3/h5-13,15-16H,4,14H2,1-3H3,(H,25,27) CAHURFTWFHHOPU-UHFFFAOYSA-N 279011 N-benzyl-5-(2-ethoxy-3-pyridyl)-1-isopropyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 41::US10512632, Example 41::US10618913, Example S41::US10766893, Example S41::US10806718, Example 41::US11026923, Example 41::US11634416, Example 41 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 500 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279011 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279011&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273336 378160600 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044817 CCOc1ncccc1-c1cc(NCc2cc(C)no2)c2n(ncc2n1)C(C)C InChI=1S/C21H24N6O2/c1-5-28-21-16(7-6-8-22-21)17-10-18(23-11-15-9-14(4)26-29-15)20-19(25-17)12-24-27(20)13(2)3/h6-10,12-13H,5,11H2,1-4H3,(H,23,25) ZGFGKVRUAVJQMR-UHFFFAOYSA-N 279012 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(3-methylisoxazol-5-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 42::US10512632, Example 42::US10766893, Example S42::US10806718, Example 42::US11026923, Example 42::US11634416, Example 42 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 82.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279012&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273341 378160601 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044820 CCOc1ncccc1-c1cc(NCc2noc(C)n2)c2n(ncc2n1)C(C)C InChI=1S/C20H23N7O2/c1-5-28-20-14(7-6-8-21-20)15-9-16(22-11-18-24-13(4)29-26-18)19-17(25-15)10-23-27(19)12(2)3/h6-10,12H,5,11H2,1-4H3,(H,22,25) SDTZIRBETDMBLS-UHFFFAOYSA-N 279013 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 43::US10512632, Example 43::US10766893, Example S43::US10806718, Example 43::US11026923, Example 43::US11634416, Example 43 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 30.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279013&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273344 378160602 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044823 CCOc1ncccc1-c1cc(NCc2cc(C)n(C)n2)c2n(ncc2n1)C(C)C InChI=1S/C22H27N7O/c1-6-30-22-17(8-7-9-23-22)18-11-19(24-12-16-10-15(4)28(5)27-16)21-20(26-18)13-25-29(21)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,24,26) RWTZKAWRGHZQKR-UHFFFAOYSA-N 279014 N-[(1,5-dimethylpyrazol-3-yl)methyl]-5-(2-ethoxy-3-pyridyl)-1-isopropyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 44::US10512632, Example 44::US10766893, Example S44::US10806718, Example 44::US11026923, Example 44::US11634416, Example 44 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 19.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279014 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279014&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273342 378160603 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044826 CCOc1ncccc1-c1cc(NCc2ccc(=O)n(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(8-7-11-25-24)19-12-20(26-13-17-9-10-21(31)29(5)14-17)23-22(27-19)16(4)28-30(23)15(2)3/h7-12,14-15H,6,13H2,1-5H3,(H,26,27) IFSZKCSGKSFXTM-UHFFFAOYSA-N 279015 3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4-yl)methyl)amino)-1H-pyrazolo[4,3-b]pyridin-5-yl)-1-methylpyridin-2(1H)-one::US10034861, Example 45::US10512632, Example 45::US10806718, Example 45::US11026923, Example 45::US11491140, Example 45::US11634416, Example 45 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.00 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279015 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279015&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273343 378160604 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044829 CCOc1ncccc1-c1cc(NCc2c[nH]c(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H27N7O/c1-6-30-22-17(8-7-9-23-22)18-10-19(25-12-16-11-24-15(5)26-16)21-20(27-18)14(4)28-29(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,24,26)(H,25,27) OESORFJHOJQXKR-UHFFFAOYSA-N 279016 5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((2-methyl-1H-imidazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 46::US10512632, Example 46::US10766893, Example S46::US10806718, Example 46::US11026923, Example 46::US11491140, Example 46::US11634416, Example 46 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 5.00 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279016&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273345 378160605 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044832 CCOc1ncccc1-c1cc(NCc2cc(C)[nH]n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H27N7O/c1-6-30-22-17(8-7-9-23-22)18-11-19(24-12-16-10-14(4)26-27-16)21-20(25-18)15(5)28-29(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,24,25)(H,26,27) BKIZQOUWXXJIIE-UHFFFAOYSA-N 279017 5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((5-methyl-1H-pyrazol-3-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 47::US10512632, Example 47::US10766893, Example S54::US10806718, Example 47::US11026923, Example 47::US11491140, Example 47::US11634416, Example 47 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.60 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279017&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273346 378160606 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044835 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(CC)nc(C)c2n1 InChI=1S/C21H25N7O/c1-5-28-20-18(23-11-15-12-24-27(4)13-15)10-17(25-19(20)14(3)26-28)16-8-7-9-22-21(16)29-6-2/h7-10,12-13H,5-6,11H2,1-4H3,(H,23,25) ALQSQGPOANFHOP-UHFFFAOYSA-N 279018 5-(2-ethoxypyridin-3-yl)-1-ethyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 48::US10512632, Example 48::US10618913, Example S48::US10766893, Example S48::US10806718, Example 48::US11026923, Example 48::US11491140, Example 48::US11634416, Example 48 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 38.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279018&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273347 378160607 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044838 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1cccn(C)c1=O InChI=1S/C21H25N7O/c1-13(2)28-20-18(22-10-15-11-23-27(5)12-15)9-17(24-19(20)14(3)25-28)16-7-6-8-26(4)21(16)29/h6-9,11-13H,10H2,1-5H3,(H,22,24) MRQVRXHGMURIIP-UHFFFAOYSA-N 279019 3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4-yl)methyl)amino)-1H-pyrazolo[4,3-b]pyridin-5-yl)-1-methylpyridin-2(1H)-one::US10034861, Example 49::US10512632, Example 49::US10766893, Example S49::US10806718, Example 49::US11026923, Example 49::US11491140, Example 49::US11634416, Example 49 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 170 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279019 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279019&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273348 378160608 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044841 CCOc1ncccc1-c1cc(NCc2nc(C)co2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6O2/c1-6-29-22-16(8-7-9-23-22)17-10-18(24-11-19-25-14(4)12-30-19)21-20(26-17)15(5)27-28(21)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,24,26) LWOWQQZYEXAZTD-UHFFFAOYSA-N 279020 5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((4-methyloxazol-2-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine 2,2,2-trifluoroacetate::US10034861, Example 50::US10512632, Example 50::US10766893, Example S50::US10806718, Example 50::US11026923, Example 50::US11491140, Example 50::US11634416, Example 50 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 9.00 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279020 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279020&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273350 378160609 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044844 CCOc1ncccc1-c1cc(NCc2cn(C)c(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H29N7O/c1-7-31-23-18(9-8-10-24-23)19-11-20(25-12-17-13-29(6)16(5)26-17)22-21(27-19)15(4)28-30(22)14(2)3/h8-11,13-14H,7,12H2,1-6H3,(H,25,27) RIBLUNUCLUPFGL-UHFFFAOYSA-N 279021 N-((1,2-dimethyl-1H-imidazol-4-yl)methyl)-5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-1H-pyrazolo[4,3-b]pyridin-7-amine 2,2,2-trifluoroacetate::US10034861, Example 51::US10512632, Example 51::US10766893, Example S51::US10806718, Example 51::US11026923, Example 51::US11491140, Example 51::US11634416, Example 51 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 53.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279021 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279021&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273354 378160610 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044847 CCOc1ncccc1-c1cc(NCc2noc(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H25N7O2/c1-6-29-21-15(8-7-9-22-21)16-10-17(23-11-18-24-14(5)30-27-18)20-19(25-16)13(4)26-28(20)12(2)3/h7-10,12H,6,11H2,1-5H3,(H,23,25) GALBTAGDVOLYTK-UHFFFAOYSA-N 279022 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 52::US10512632, Example 52::US10766893, Example S52::US10806718, Example 52::US11026923, Example 52::US11491140, Example 52 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.90 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279022 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279022&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273351 378160611 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044850 CCOc1ncccc1-c1cc(NCc2ncon2)c2n(nc(C)c2n1)C(C)C InChI=1S/C20H23N7O2/c1-5-28-20-14(7-6-8-21-20)15-9-16(22-10-17-23-11-29-26-17)19-18(24-15)13(4)25-27(19)12(2)3/h6-9,11-12H,5,10H2,1-4H3,(H,22,24) HUAHNRHWFFYRAT-UHFFFAOYSA-N 279023 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1,2,4-oxadiazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 53::US10512632, Example 53::US10766893, Example S53::US10806718, Example 53::US11026923, Example 53::US11491140, Example 53::US11634416, Example 53 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 9.30 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279023&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273357 378160612 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044853 CCOc1ncccc1-c1cc(NCc2cc(C)n(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H29N7O/c1-7-31-23-18(9-8-10-24-23)19-12-20(25-13-17-11-15(4)29(6)28-17)22-21(26-19)16(5)27-30(22)14(2)3/h8-12,14H,7,13H2,1-6H3,(H,25,26) LOSBPLVFUGTAOA-UHFFFAOYSA-N 279024 N-[(1,5-dimethylpyrazol-3-yl)methyl]-5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 54::US10512632, Example 54::US10806718, Example 54::US11026923, Example 54::US11491140, Example 54::US11634416, Example 54 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.390 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279024 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279024&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273352 378160613 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044856 CCOc1ncccc1-c1cc(NCc2n[nH]c(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-6-30-21-15(8-7-9-22-21)16-10-17(23-11-18-24-14(5)26-27-18)20-19(25-16)13(4)28-29(20)12(2)3/h7-10,12H,6,11H2,1-5H3,(H,23,25)(H,24,26,27) QVFBWQCMGPADBC-UHFFFAOYSA-N 279025 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methyl-1H-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 55::US10512632, Example 55::US10766893, Example S55::US10806718, Example 55::US11026923, Example 55::US11491140, Example 55::US11634416, Example 55 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 3.40 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279025&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273353 378160614 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044859 CCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(ncc2n1)C(C)C InChI=1S/C20H24N8O/c1-5-29-20-14(7-6-8-21-20)15-9-16(22-11-18-23-12-27(4)26-18)19-17(25-15)10-24-28(19)13(2)3/h6-10,12-13H,5,11H2,1-4H3,(H,22,25) LBAWYUCYPDZBSF-UHFFFAOYSA-N 279026 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 56::US10512632, Example 56::US10766893, Example S56::US10806718, Example 56::US11026923, Example 56::US11491140, Example 56::US11634416, Example 56 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 16.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279026&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273358 378160615 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044862 CCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(ncc2n1)C(C)C InChI=1S/C20H23N7O/c1-4-28-20-15(6-5-8-21-20)16-10-17(22-11-14-7-9-23-26-14)19-18(25-16)12-24-27(19)13(2)3/h5-10,12-13H,4,11H2,1-3H3,(H,22,25)(H,23,26) RZEYZCLEVMBHDS-UHFFFAOYSA-N 279027 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 57::US10512632, Example 57::US10766893, Example S57::US10806718, Example 57::US11026923, Example 57::US11491140, Example 57::US11634416, Example 57 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 98.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279027&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273355 378160616 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044865 CCOc1ncccc1-c1cc(NCc2cn(C)cn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H27N7O/c1-6-30-22-17(8-7-9-23-22)18-10-19(24-11-16-12-28(5)13-25-16)21-20(26-18)15(4)27-29(21)14(2)3/h7-10,12-14H,6,11H2,1-5H3,(H,24,26) LRTCNZDFQQIFPH-UHFFFAOYSA-N 279028 5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((1-methyl-1H-imidazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine 2,2,2-trifluoroacetate::US10034861, Example 58::US10512632, Example 58::US10766893, Example S58::US10806718, Example 58::US11026923, Example 58::US11491140, Example 58::US11634416, Example 58 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.10 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279028&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273360 378160617 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044868 CCOc1ncccc1-c1cc(NCc2nnco2)c2n(nc(C)c2n1)C(C)C InChI=1S/C20H23N7O2/c1-5-28-20-14(7-6-8-21-20)15-9-16(22-10-17-25-23-11-29-17)19-18(24-15)13(4)26-27(19)12(2)3/h6-9,11-12H,5,10H2,1-4H3,(H,22,24) AHFKEZBAZQXEDY-UHFFFAOYSA-N 279029 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1,3,4-oxadiazol-2-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 59::US10512632, Example 59::US10766893, Example S59::US10806718, Example 59::US11026923, Example 59::US11491140, Example 59::US11634416, Example 59 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 55.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279029&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273356 378160618 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044871 CCOc1ncccc1\C=C\C(\NCC(=N)C=C)=C1/CC(C)=NN1C(C)C InChI=1S/C21H29N5O/c1-6-18(22)14-24-19(20-13-16(5)25-26(20)15(3)4)11-10-17-9-8-12-23-21(17)27-7-2/h6,8-12,15,22,24H,1,7,13-14H2,2-5H3/b11-10+,20-19-,22-18? RENINPNWZYUWPI-ZXJAEXQBSA-N 501429 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N- [(1-methylpyrazol-3-yl)methyl]pyrazolo[4,3- b]pyridin-7-amine::US11026923, Example 60 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 6.50 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501429 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501429&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 155773336 459086717 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044874 CC(C)N1N=C(C)C\C1=C(\NCc1cnn(C)c1)/C=C/c1cn(C)nc1C InChI=1S/C20H29N7/c1-14(2)27-20(9-15(3)23-27)19(21-10-17-11-22-25(5)12-17)8-7-18-13-26(6)24-16(18)4/h7-8,11-14,21H,9-10H2,1-6H3/b8-7+,20-19- KSAWSLXAMPVOHI-DFCCZADTSA-N 501430 5-(1,3-dimethylpyrazol-4-yl)-1-isopropyl-3- methyl-N-[(1-methylpyrazol-4- yl)methyl]pyrazole[4.3-b]pyridin-7-amine::US11026923, Example 61 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 550 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501430 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501430&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 155773343 459086718 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044877 COc1ncccc1\C=C\C(\NCc1cnn(C)c1)=C1/CC(C)=NN1C(C)C InChI=1S/C21H28N6O/c1-15(2)27-20(11-16(3)25-27)19(23-12-17-13-24-26(4)14-17)9-8-18-7-6-10-22-21(18)28-5/h6-10,13-15,23H,11-12H2,1-5H3/b9-8+,20-19- JHGCAWXOMLLFMA-GGXOMMRWSA-N 501431 1-isopropyl-5-(2-methoxy-3-pyridyl)-3-methyl- N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3- b]pyridin-7-amine::US11026923, Example 62 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 16.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501431 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501431&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 155773331 459086719 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044880 COc1ccccc1\C=C\C(\NCc1cnn(C)c1)=C1/CC(C)=NN1C(C)C InChI=1S/C22H29N5O/c1-16(2)27-21(12-17(3)25-27)20(23-13-18-14-24-26(4)15-18)11-10-19-8-6-7-9-22(19)28-5/h6-11,14-16,23H,12-13H2,1-5H3/b11-10+,21-20- VUFWHVVECOLPCB-VGESBEFTSA-N 501432 1-isopropyl-5-(2-methoxyphenyl)-3-methyl-N- [(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3- b]pyridin-7-amine::US11026923, Example 63 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 64.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501432&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 155773329 459086720 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044883 CC(C)N1N=C(C)C\C1=C(\NCc1cnn(C)c1)/C=C/c1ccccc1 InChI=1S/C21H27N5/c1-16(2)26-21(12-17(3)24-26)20(11-10-18-8-6-5-7-9-18)22-13-19-14-23-25(4)15-19/h5-11,14-16,22H,12-13H2,1-4H3/b11-10+,21-20- ZEENICWEXZXITL-VGESBEFTSA-N 501433 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4- yl)methyl]-5-phenyl-pyrazolo[4,3-b]pyridin-7- amine::US11026923, Example 64 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 52.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501433 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501433&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 155773335 459086721 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044886 CC(C)N1N=C(C)C\C1=C(\NCc1cnn(C)c1)/C=C/c1ccsc1C InChI=1S/C20H27N5S/c1-14(2)25-20(10-15(3)23-25)19(7-6-18-8-9-26-16(18)4)21-11-17-12-22-24(5)13-17/h6-9,12-14,21H,10-11H2,1-5H3/b7-6+,20-19- WAPDOWPXYQRTDC-NVZWLTETSA-N 501434 1-isopropyl-3-methyl-N-[1-methylpyrazol-4- yl)methyl]-5-(2-methyl-3-thienyl)pyrazolo[4,3- b]pyridin-7-amine::US11026923, Example 65 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 7.90 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501434 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501434&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 155773326 459086722 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044889 CC(C)N1N=C(C)C\C1=C(\NCc1cnn(C)c1)/C=C/c1cnn(C)c1C InChI=1S/C20H29N7/c1-14(2)27-20(9-15(3)24-27)19(21-10-17-11-22-25(5)13-17)8-7-18-12-23-26(6)16(18)4/h7-8,11-14,21H,9-10H2,1-6H3/b8-7+,20-19- DURMBXZBTJGGSF-DFCCZADTSA-N 501435 5-(1,5-dimethylpyrazol-4-yl)-1-isopropyl-3- methyl-N-[(1-methylpyrazol-4- yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US11026923, Example 66 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 210 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501435 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501435&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 155773345 459086723 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044892 CCOc1ncccc1\C=C\C(\NCc1ccn(C)n1)=C1/CC(C)=NN1C(C)CC InChI=1S/C23H32N6O/c1-6-18(4)29-22(15-17(3)26-29)21(25-16-20-12-14-28(5)27-20)11-10-19-9-8-13-24-23(19)30-7-2/h8-14,18,25H,6-7,15-16H2,1-5H3/b11-10+,22-21- WUVAZFJCZQZLEV-ABZBQOJRSA-N 501436 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1- methylpropyl]-N-[1-methylpyrazol-3- yl)methyl]pyrazolo[4,3-b]pyridin-7-amine, enantiomer 2::US11026923, Example 67 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 9.60 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501436 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501436&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 155773325 459086724 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044895 CCCOc1ncccc1C\C=C(\NCc1nnn(C)n1)c1cc(C)nn1C(C)CC InChI=1S/C22H32N8O/c1-6-13-31-22-18(9-8-12-23-22)10-11-19(24-15-21-25-28-29(5)27-21)20-14-16(3)26-30(20)17(4)7-2/h8-9,11-12,14,17,24H,6-7,10,13,15H2,1-5H3/b19-11+ GHHGVGRPPLMROZ-YBFXNURJSA-N 501437 3-methyl-1-[1-methylpropyl]-N-[(2- methyltetrazol-5-yl]methyl]-5-(2-prepoxy-3- pyridyl)pyrazolo[4,3-b]pyridin-7-amine, enantiomer 2::US11026923, Example 68 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.790 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501437 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501437&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 155773334 459086725 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044898 CCOc1ncccc1C\C=C(\NCc1cnn(C)c1)c1ccnn1C(C)CC InChI=1S/C22H30N6O/c1-5-17(3)28-21(11-13-25-28)20(24-14-18-15-26-27(4)16-18)10-9-19-8-7-12-23-22(19)29-6-2/h7-8,10-13,15-17,24H,5-6,9,14H2,1-4H3/b20-10+ XIDRGBXOXDHAGV-KEBDBYFISA-N 501438 5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N- [(1-methylpyrazo1-4-yl)methyl]pyrazolo[4,3- b]pyridin-7-amine, enantiomer 1::US11026923, Example 69::US11026923, Example 70 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 14.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501438 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501438&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 155773344 459086726 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044901 CCOc1ncccc1C\C=C(\NCc1cnn(C)c1)c1ccnn1C(C)CC InChI=1S/C22H30N6O/c1-5-17(3)28-21(11-13-25-28)20(24-14-18-15-26-27(4)16-18)10-9-19-8-7-12-23-22(19)29-6-2/h7-8,10-13,15-17,24H,5-6,9,14H2,1-4H3/b20-10+ XIDRGBXOXDHAGV-KEBDBYFISA-N 501438 5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N- [(1-methylpyrazo1-4-yl)methyl]pyrazolo[4,3- b]pyridin-7-amine, enantiomer 1::US11026923, Example 69::US11026923, Example 70 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 140 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501438 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501438&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 155773344 459086726 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044904 CCOc1ncccc1-c1cc(NCc2scnc2C)c2n(ncc2n1)C(C)C InChI=1S/C21H24N6OS/c1-5-28-21-15(7-6-8-22-21)16-9-17(23-11-19-14(4)24-12-29-19)20-18(26-16)10-25-27(20)13(2)3/h6-10,12-13H,5,11H2,1-4H3,(H,23,26) CKGZFAMXPLRINR-UHFFFAOYSA-N 424981 US10512632, Example 71::US10766893, Example S71::US10806718, Example 71::US11026923, Example 71::US11491140, Example 71::US11634416, Example 71 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 170 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=424981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=424981&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138536011 434150492 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044907 CCOc1ncccc1-c1cc(OCc2cnc(C)o2)c(NC(C)C)c(n1)C(C)=N InChI=1S/C22H27N5O3/c1-6-28-22-17(8-7-9-24-22)18-10-19(29-12-16-11-25-15(5)30-16)21(26-13(2)3)20(27-18)14(4)23/h7-11,13,23,26H,6,12H2,1-5H3 FBPBJZZMBZEJSF-UHFFFAOYSA-N 501441 5-[[5-(2-ethoxy-3-pyridyl)-1-isopropyl-3- methyl-pyrazolo[4,3-b]pyridin-7-yl]oxymethyl]- 2-methyl-oxazole::US11026923, Example 72 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 14.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501441&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 155028560 459086727 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044910 CCOc1ncccc1-c1cc(NCc2ccncn2)c(NC(C)C)c(n1)C(C)=N InChI=1S/C22H27N7O/c1-5-30-22-17(7-6-9-25-22)18-11-19(26-12-16-8-10-24-13-27-16)21(28-14(2)3)20(29-18)15(4)23/h6-11,13-14,23,28H,5,12H2,1-4H3,(H,26,29) WUGQDYJBPAWXRS-UHFFFAOYSA-N 501442 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N- (pyrimidin-4-ylmethyl)pyrazolo[4,3-b]pyridin-7- amine::US11026923, Example 73 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 81.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501442 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501442&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 155773333 459086728 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044913 CCOc1ncccc1-c1cc(NCc2ncccn2)c(NC(C)C)c(n1)C(C)=N InChI=1S/C22H27N7O/c1-5-30-22-16(8-6-9-26-22)17-12-18(27-13-19-24-10-7-11-25-19)21(28-14(2)3)20(29-17)15(4)23/h6-12,14,23,28H,5,13H2,1-4H3,(H,27,29) ZFZUGJNEEZJCBU-UHFFFAOYSA-N 501443 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N- (pyrimidin-2-ylmethyl)pyrazolo[4,3-b]pyridin-7- amine::US11026923, Example 74 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.10 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501443&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138746928 459086729 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044916 CCOc1ncccc1-c1cc(NCc2nccc(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O/c1-6-31-23-17(8-7-10-25-23)18-12-19(26-13-20-24-11-9-15(4)27-20)22-21(28-18)16(5)29-30(22)14(2)3/h7-12,14H,6,13H2,1-5H3,(H,26,28) ZCARSOPJYGJCRQ-UHFFFAOYSA-N 279045 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(4-methylpyrimidin-2-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 75::US10512632, Example 75::US10806718, Example 75::US11026923, Example 75::US11491140, Example 75::US11634416, Example 75 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 9.90 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279045&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273374 378160633 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044919 CCOc1ncccc1-c1cc(NCc2cnccn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H25N7O/c1-5-30-22-17(7-6-8-25-22)18-11-19(26-13-16-12-23-9-10-24-16)21-20(27-18)15(4)28-29(21)14(2)3/h6-12,14H,5,13H2,1-4H3,(H,26,27) DTEHKURDWHCADV-UHFFFAOYSA-N 279046 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(pyrazin-2-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 76::US10512632, Example 76::US10766893, Example S76::US10806718, Example 76::US11026923, Example 76::US11491140, Example 76::US11634416, Example 76 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 23.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279046&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273373 378160634 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044922 CCOc1ncccc1-c1cc(NCc2cccnc2C(F)(F)F)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H25F3N6O/c1-5-34-23-17(9-7-11-29-23)18-12-19(21-20(31-18)15(4)32-33(21)14(2)3)30-13-16-8-6-10-28-22(16)24(25,26)27/h6-12,14H,5,13H2,1-4H3,(H,30,31) TZBBGNNWRKPAEH-UHFFFAOYSA-N 279047 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[2-(trifluoromethyl)-3-pyridyl]methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 77::US10512632, Example 77::US10766893, Example S77::US10806718, Example 77::US11026923, Example 77::US11491140, Example 77::US11634416, Example 77 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 21.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279047&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273376 378160635 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044925 CCOc1ncccc1-c1cc(NCc2ccn(C)c(=O)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(8-7-10-25-24)19-13-20(26-14-17-9-11-29(5)21(31)12-17)23-22(27-19)16(4)28-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,26,27) IBAWDCALOOJODQ-UHFFFAOYSA-N 279048 4-[[[5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-yl]amino]methyl]-1-methyl-pyridin-2-one::US10034861, Example 78::US10512632, Example 78::US10766893, Example S78::US10806718, Example 78::US11026923, Example 78::US11491140, Example 78::US11634416, Example 78 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 27.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279048&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273377 378160636 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044928 CCNc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H28N8/c1-6-23-22-17(8-7-9-24-22)18-10-19(25-11-16-12-26-29(5)13-16)21-20(27-18)15(4)28-30(21)14(2)3/h7-10,12-14H,6,11H2,1-5H3,(H,23,24)(H,25,27) ZEUKRJZWWLBXIK-UHFFFAOYSA-N 279049 5-(2-(ethylamino)pyridin-3-yl)-1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 79::US10512632, Example 79::US10766893, Example S79::US10806718, Example 79::US11026923, Example 79::US11491140, Example 79::US11634416, Example 79 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 230 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279049&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273375 378160637 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044931 CCOc1ncccc1-c1cc(NCc2cc(OC)ccn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-19(8-7-10-26-24)20-13-21(27-14-17-12-18(31-5)9-11-25-17)23-22(28-20)16(4)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) BVKDBZHCRMPMSA-UHFFFAOYSA-N 279050 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(4-methoxy-2-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 81::US10512632, Example 81::US10766893, Example S81::US10806718, Example 81::US11026923, Example 81::US11491140, Example 81::US11634416, Example 81 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.000 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279050&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273378 378160638 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044934 CCOc1ncccc1-c1cc(NCc2cncc(OC)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O2/c1-6-32-23-17(8-7-9-25-23)18-10-19(26-12-16-11-24-13-20(27-16)31-5)22-21(28-18)15(4)29-30(22)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,26,28) OSHMEGNKNUJDSU-UHFFFAOYSA-N 279051 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(6-methoxypyrazin-2-yl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 82::US10512632, Example 82::US10766893, Example S82::US10806718, Example 82::US11026923, Example 82::US11491140, Example 82::US11634416, Example 82 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 16.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279051&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273380 378160639 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044937 CCOc1ncccc1-c1cc(NCc2ncc(F)cn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H24FN7O/c1-5-31-22-16(7-6-8-24-22)17-9-18(25-12-19-26-10-15(23)11-27-19)21-20(28-17)14(4)29-30(21)13(2)3/h6-11,13H,5,12H2,1-4H3,(H,25,28) ZIOQYWFVMVDZRK-UHFFFAOYSA-N 279052 5-(2-ethoxy-3-pyridyl)-N-[(5-fluoropyrimidin-2-yl)methyl]-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 83::US10512632, Example 83::US10766893, Example S83::US10806718, Example 83::US11026923, Example 83::US11491140, Example 83::US11634416, Example 83 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 17.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279052&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273381 378160640 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044940 CCOc1ncccc1-c1cc(NCc2cccnc2C)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O/c1-6-31-24-19(10-8-12-26-24)20-13-21(27-14-18-9-7-11-25-16(18)4)23-22(28-20)17(5)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) JOFWPJKNNJOGJF-UHFFFAOYSA-N 279053 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methyl-3-pyridyl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 84::US10512632, Example 84::US10766893, Example S84::US10806718, Example 84::US11026923, Example 84::US11491140, Example 84::US11634416, Example 84 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 19.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279053&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273382 378160641 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044943 CCOc1ncccc1-c1cc(NCc2cccnc2F)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H25FN6O/c1-5-31-23-17(9-7-11-26-23)18-12-19(27-13-16-8-6-10-25-22(16)24)21-20(28-18)15(4)29-30(21)14(2)3/h6-12,14H,5,13H2,1-4H3,(H,27,28) JJLMBZVLDAMDGO-UHFFFAOYSA-N 279054 5-(2-ethoxy-3-pyridyl)-N-[(2-fluoro-3-pyridyl)methyl]-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 85::US10512632, Example 85::US10766893, Example S85::US10806718, Example 85::US11026923, Example 85::US11491140, Example 85::US11634416, Example 85 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.40 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279054&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273384 378160642 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044946 CCOc1ncccc1-c1cc(NCc2cccnc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(10-8-12-26-24)19-13-20(27-14-17-9-7-11-25-23(17)31-5)22-21(28-19)16(4)29-30(22)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) LOZUTDKVJLMDTB-UHFFFAOYSA-N 279055 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 172::US10034861, Example 180::US10034861, Example 181::US10034861, Example 182::US10034861, Example 86::US10512632, Example 86::US10766893, Example S86::US10806718, Example 182::US11026923, Example 182::US11491140, Example 86::US11634416, Example 86 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 20.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279055&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273386 378160643 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044949 CCOc1ncccc1-c1cc(NCc2ccc(C)nc2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O/c1-6-31-24-19(8-7-11-25-24)20-12-21(27-14-18-10-9-16(4)26-13-18)23-22(28-20)17(5)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) VEZPCNBBBMUATR-UHFFFAOYSA-N 279056 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(6-methyl-3-pyridyl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 87::US10512632, Example 87::US10766893, Example S87::US10806718, Example 87::US11026923, Example 87::US11491140, Example 87::US11634416, Example 87 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 6.30 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279056 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279056&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273383 378160644 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044952 CCOc1ncccc1-c1cc(NCc2ccccc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C25H29N5O2/c1-6-32-25-19(11-9-13-26-25)20-14-21(27-15-18-10-7-8-12-22(18)31-5)24-23(28-20)17(4)29-30(24)16(2)3/h7-14,16H,6,15H2,1-5H3,(H,27,28) IXQRCVAKBIMUJN-UHFFFAOYSA-N 279057 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxyphenyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 88::US10512632, Example 88::US10766893, Example S88::US10806718, Example 88::US11026923, Example 88::US11491140, Example 88::US11634416, Example 88 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 110 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279057&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273385 378160645 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044955 CCOc1ncccc1-c1cc(NCc2ccccc2F)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H26FN5O/c1-5-31-24-18(10-8-12-26-24)20-13-21(27-14-17-9-6-7-11-19(17)25)23-22(28-20)16(4)29-30(23)15(2)3/h6-13,15H,5,14H2,1-4H3,(H,27,28) PBVAXRZBSWSQNU-UHFFFAOYSA-N 279058 5-(2-ethoxy-3-pyridyl)-N-[(2-fluorophenyl)methyl]-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 89::US10512632, Example 89::US10766893, Example S89::US10806718, Example 89::US11026923, Example 89::US11491140, Example 89::US11634416, Example 89 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 61.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279058&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273388 378160646 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044958 CCOc1ncccc1-c1cc(NCc2ccccc2C(F)(F)F)c2n(nc(C)c2n1)C(C)C InChI=1S/C25H26F3N5O/c1-5-34-24-18(10-8-12-29-24)20-13-21(23-22(31-20)16(4)32-33(23)15(2)3)30-14-17-9-6-7-11-19(17)25(26,27)28/h6-13,15H,5,14H2,1-4H3,(H,30,31) XUHWSBHEGYQEDI-UHFFFAOYSA-N 279059 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[2-(trifluoromethyl)phenyl]methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 90::US10512632, Example 90::US10766893, Example S90::US10806718, Example 90::US11026923, Example 90::US11491140, Example 90::US11634416, Example 90 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 270 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279059&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273387 378160647 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044961 CCOc1ncccc1-c1cc(NCc2nccnc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O2/c1-6-32-22-16(8-7-9-25-22)17-12-18(27-13-19-23(31-5)26-11-10-24-19)21-20(28-17)15(4)29-30(21)14(2)3/h7-12,14H,6,13H2,1-5H3,(H,27,28) GJZNHSHBNVLOAO-UHFFFAOYSA-N 279060 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(3-methoxypyrazin-2-yl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 91::US10512632, Example 91::US10766893, Example S91::US10806718, Example 91::US11026923, Example 91::US11491140, Example 91::US11634416, Example 91 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 27.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279060&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273389 378160648 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044964 CCOc1ncccc1-c1cc(NCc2cnccc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(8-7-10-26-24)19-12-20(27-14-17-13-25-11-9-21(17)31-5)23-22(28-19)16(4)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) BHINMZMKXRIBEG-UHFFFAOYSA-N 279061 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(4-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 92::US10512632, Example 92::US10766893, Example S92::US10806718, Example 92::US11026923, Example 92::US11491140, Example 92::US11634416, Example 92 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 47.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279061&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273390 378160649 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044967 CCCOc1ncccc1-c1cc(NCc2nnn(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H27N9O/c1-6-10-31-21-15(8-7-9-22-21)16-11-17(23-12-18-25-28-29(5)27-18)20-19(24-16)14(4)26-30(20)13(2)3/h7-9,11,13H,6,10,12H2,1-5H3,(H,23,24) IEZRRRCALKIRBN-UHFFFAOYSA-N 279062 1-isopropyl-3-methyl-N-[(2-methyltetrazol-5-yl)methyl]-5-(2-propoxy-3-pyridyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 93::US10512632, Example 93::US10766893, Example S93::US10806718, Example 93::US11026923, Example 93::US11491140, Example 93::US11634416, Example 93 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4.30 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279062&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273393 378160650 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044970 CCCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H29N7O/c1-6-10-31-23-18(8-7-9-24-23)19-11-20(25-12-17-13-26-29(5)14-17)22-21(27-19)16(4)28-30(22)15(2)3/h7-9,11,13-15H,6,10,12H2,1-5H3,(H,25,27) JYRPZCKZXZYAOY-UHFFFAOYSA-N 279063 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-(2-propoxy-3-pyridyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 94::US10512632, Example 94::US10766893, Example S94::US10806718, Example 94::US11026923, Example 94::US11491140, Example 94::US11634416, Example 94 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.40 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279063&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273391 378160651 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044973 COc1ncccc1CNc1cc(nc2c(C)nn(C(C)C)c12)-c1cccnc1OC InChI=1S/C23H26N6O2/c1-14(2)29-21-19(26-13-16-8-6-10-24-22(16)30-4)12-18(27-20(21)15(3)28-29)17-9-7-11-25-23(17)31-5/h6-12,14H,13H2,1-5H3,(H,26,27) YPNDBZHHIYJRNN-UHFFFAOYSA-N 279064 1-isopropyl-5-(2-methoxy-3-pyridyl)-N-[(2-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 95::US10512632, Example 95::US10766893, Example S95::US10806718, Example 95::US11026923, Example 95::US11491140, Example 95::US11634416, Example 95 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 42.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279064 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279064&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273392 378160652 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044976 COc1ccc(CNc2cc(nc3c(C)nn(C(C)C)c23)-c2cccnc2OC)cn1 InChI=1S/C23H26N6O2/c1-14(2)29-22-19(25-12-16-8-9-20(30-4)26-13-16)11-18(27-21(22)15(3)28-29)17-7-6-10-24-23(17)31-5/h6-11,13-14H,12H2,1-5H3,(H,25,27) HUQJJAUBVULGLS-UHFFFAOYSA-N 279065 1-isopropyl-5-(2-methoxy-3-pyridyl)-N-[(6-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 96::US10512632, Example 96::US10766893, Example S96::US10806718, Example 96::US11026923, Example 96::US11491140, Example 96::US11634416, Example 96 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 18.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279065&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273394 378160653 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044979 CC(C)Oc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H29N7O/c1-14(2)30-22-20(25-11-17-12-26-29(6)13-17)10-19(27-21(22)16(5)28-30)18-8-7-9-24-23(18)31-15(3)4/h7-10,12-15H,11H2,1-6H3,(H,25,27) IWDHUHWZRSHWGD-UHFFFAOYSA-N 279066 5-(2-isopropoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 97::US10512632, Example 97::US10766893, Example S97::US10806718, Example 97::US11026923, Example 97::US11491140, Example 97::US11634416, Example 97 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.40 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279066&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273395 378160654 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044982 CCOc1ncccc1-c1cc(NCc2cn[nH]n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C20H24N8O/c1-5-29-20-15(7-6-8-21-20)16-9-17(22-10-14-11-23-27-25-14)19-18(24-16)13(4)26-28(19)12(2)3/h6-9,11-12H,5,10H2,1-4H3,(H,22,24)(H,23,25,27) GDHBBWKRORXRCC-UHFFFAOYSA-N 501467 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N- (1H-1,2,4-triazol-3-ylmethyl)pyrazolo[4,3- b]pyridin-7-amine::US11026923, Example 98 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 7.20 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501467 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501467&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 155773332 459086730 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044985 CCOc1ncccc1-c1cc(NCc2nn[nH]n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C19H23N9O/c1-5-29-19-13(7-6-8-20-19)14-9-15(21-10-16-23-26-27-24-16)18-17(22-14)12(4)25-28(18)11(2)3/h6-9,11H,5,10H2,1-4H3,(H,21,22)(H,23,24,26,27) DBRGOFPEANLZGU-UHFFFAOYSA-N 279068 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(2H-tetrazol-5-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 99::US10512632, Example 99::US10766893, Example S99::US10806718, Example 99::US11026923, Example 99::US11491140, Example 99::US11634416, Example 99 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.730 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279068&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273399 378160656 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044988 CCOc1ncccc1-c1cc(NCc2ccccn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H26N6O/c1-5-30-23-18(10-8-12-25-23)19-13-20(26-14-17-9-6-7-11-24-17)22-21(27-19)16(4)28-29(22)15(2)3/h6-13,15H,5,14H2,1-4H3,(H,26,27) GWMDZOSIIBARTA-UHFFFAOYSA-N 279069 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(2-pyridylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 100::US10512632, Example 100::US10766893, Example S100::US10806718, Example 100::US11026923, Example 100::US11491140, Example 100::US11634416, Example 100 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 6.30 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279069&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273397 378160657 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044991 CCOc1ncccc1-c1cc(NCc2cccc(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O/c1-6-31-24-19(11-8-12-25-24)20-13-21(26-14-18-10-7-9-16(4)27-18)23-22(28-20)17(5)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,26,28) HBRGVUVPCCNRAT-UHFFFAOYSA-N 279070 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(6-methyl-2-pyridyl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 101::US10512632, Example 101::US10766893, Example S101::US10806718, Example 101::US11026923, Example 101::US11491140, Example 101::US11634416, Example 101 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 20.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279070&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273398 378160658 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044994 CCOc1ncccc1-c1cc(NCc2cccc(OC)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(10-8-12-25-24)19-13-20(26-14-17-9-7-11-21(27-17)31-5)23-22(28-19)16(4)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,26,28) DHUHVCYRBUZRAT-UHFFFAOYSA-N 279071 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(6-methoxy-2-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 102::US10512632, Example 102::US10766893, Example S102::US10806718, Example 102::US11026923, Example 102::US11491140, Example 102::US11634416, Example 102 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.00 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279071&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273400 378160659 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044997 CCOc1ncccc1-c1cc(NCc2ccnc(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O/c1-6-31-24-19(8-7-10-26-24)20-13-21(27-14-18-9-11-25-16(4)12-18)23-22(28-20)17(5)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) MPJXQIBFZBPJFH-UHFFFAOYSA-N 279072 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methyl-4-pyridyl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 103::US10512632, Example 103::US10766893, Example S103::US10806718, Example 103::US11026923, Example 103::US11491140, Example 103::US11634416, Example 103 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 5.40 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279072&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273402 378160660 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045000 CCOc1ncccc1-c1cc(NCc2ccnc(OC)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(8-7-10-26-24)19-13-20(27-14-17-9-11-25-21(12-17)31-5)23-22(28-19)16(4)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) SJJQCULDRYOYED-UHFFFAOYSA-N 279073 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-4-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 104::US10512632, Example 104::US10766893, Example S104::US10806718, Example 104::US11026923, Example 104::US11491140, Example 104::US11634416, Example 104 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.20 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279073&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273401 378160661 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045003 CCOc1ncccc1-c1cc(NCc2ccnc(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O/c1-6-31-23-18(8-7-10-25-23)19-12-20(26-13-17-9-11-24-16(5)27-17)22-21(28-19)15(4)29-30(22)14(2)3/h7-12,14H,6,13H2,1-5H3,(H,26,28) OEGPBHHKEYGZCG-UHFFFAOYSA-N 279074 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methylpyrimidin-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 105::US10512632, Example 105::US10766893, Example S105::US10806718, Example 105::US11026923, Example 105::US11491140, Example 105::US11634416, Example 105 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 54.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279074&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273403 378160662 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045006 CCOc1ncccc1-c1cc(NCc2cncc(OC)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-19(8-7-9-26-24)20-11-21(27-13-17-10-18(31-5)14-25-12-17)23-22(28-20)16(4)29-30(23)15(2)3/h7-12,14-15H,6,13H2,1-5H3,(H,27,28) JCOKQWFPIMEUNS-UHFFFAOYSA-N 279075 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(5-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 106::US10512632, Example 106::US10766893, Example S106::US10806718, Example 106::US11026923, Example 106::US11491140, Example 106::US11634416, Example 106 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.10 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279075&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273404 378160663 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045009 CCOc1ncccc1-c1cc(NCc2cccc(n2)C(F)(F)F)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H25F3N6O/c1-5-34-23-17(9-7-11-28-23)18-12-19(22-21(31-18)15(4)32-33(22)14(2)3)29-13-16-8-6-10-20(30-16)24(25,26)27/h6-12,14H,5,13H2,1-4H3,(H,29,31) FVVVRFIRYVUVEI-UHFFFAOYSA-N 279076 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[6-(trifluoromethyl)-2-pyridyl]methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 107::US10512632, Example 107::US10766893, Example S107::US10806718, Example 107::US11026923, Example 107::US11491140, Example 107::US11634416, Example 107 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 110 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279076&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273405 378160664 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045012 CCOc1ncccc1-c1cc(NCc2cccn(C)c2=O)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-23-18(10-7-11-25-23)19-13-20(26-14-17-9-8-12-29(5)24(17)31)22-21(27-19)16(4)28-30(22)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,26,27) YLQLMBPUXKUVLD-UHFFFAOYSA-N 279077 3-[[[5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-yl]amino]methyl]-1-methyl-pyridin-2-one::US10034861, Example 108::US10512632, Example 108::US10766893, Example S108::US10806718, Example 108::US11026923, Example 108::US11491140, Example 108::US11634416, Example 108 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.80 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279077&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273406 378160665 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045015 CCOc1ncccc1-c1cc(NCc2cnn(CC)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H29N7O/c1-6-29-14-17(13-26-29)12-25-20-11-19(18-9-8-10-24-23(18)31-7-2)27-21-16(5)28-30(15(3)4)22(20)21/h8-11,13-15H,6-7,12H2,1-5H3,(H,25,27) IEORIQPBXNSJCP-UHFFFAOYSA-N 279078 5-(2-ethoxy-3-pyridyl)-N-[(1-ethylpyrazol-4-yl)methyl]-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 109::US10512632, Example 109::US10766893, Example S109::US10806718, Example 109::US11026923, Example 109::US11491140, Example 109::US11634416, Example 109 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4.90 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279078&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273407 378160666 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045018 CCCn1cc(CNc2cc(nc3c(C)nn(C(C)C)c23)-c2cccnc2OCC)cn1 InChI=1S/C24H31N7O/c1-6-11-30-15-18(14-27-30)13-26-21-12-20(19-9-8-10-25-24(19)32-7-2)28-22-17(5)29-31(16(3)4)23(21)22/h8-10,12,14-16H,6-7,11,13H2,1-5H3,(H,26,28) NPLKFZSTTQLUHS-UHFFFAOYSA-N 279079 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(1-propylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 110::US10512632, Example 110::US10766893, Example S110::US10806718, Example 110::US11026923, Example 110::US11491140, Example 110::US11634416, Example 110 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 11.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279079&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273408 378160667 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045021 CCOc1ncccc1-c1cc(NCc2ccc(OC)nc2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(8-7-11-25-24)19-12-20(26-13-17-9-10-21(31-5)27-14-17)23-22(28-19)16(4)29-30(23)15(2)3/h7-12,14-15H,6,13H2,1-5H3,(H,26,28) XMJAAWKICASNAA-UHFFFAOYSA-N 279080 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(6-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 111::US10512632, Example 111::US10766893, Example S111::US10806718, Example 111::US11026923, Example 111::US11491140, Example 111::US11634416, Example 111 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 28.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279080 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279080&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273409 378160668 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045024 CCOc1ncccc1-c1cc(NCc2ccc(OC)cn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-19(8-7-11-25-24)20-12-21(27-13-17-9-10-18(31-5)14-26-17)23-22(28-20)16(4)29-30(23)15(2)3/h7-12,14-15H,6,13H2,1-5H3,(H,27,28) HWSJSACIWPNYOB-UHFFFAOYSA-N 279081 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(5-methoxy-2-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 112::US10512632, Example 112::US10766893, Example S112::US10806718, Example 112::US11026923, Example 112::US11491140, Example 112::US11634416, Example 112 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 61.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279081&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273411 378160669 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045027 CCOc1ncccc1-c1cc(NCc2csc(C)n2)c2n(nc(C)c2n1)C1COC1 InChI=1S/C22H24N6O2S/c1-4-30-22-17(6-5-7-23-22)18-8-19(24-9-15-12-31-14(3)25-15)21-20(26-18)13(2)27-28(21)16-10-29-11-16/h5-8,12,16H,4,9-11H2,1-3H3,(H,24,26) BSSGJYYHYVLYMA-UHFFFAOYSA-N 279082 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(2-methylthiazol-4-yl)methyl]-1-(oxetan-3-yl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 113::US10512632, Example 113::US10618913, Example S113::US10766893, Example S113::US10806718, Example 113::US11026923, Example 113::US11491140, Example 113::US11634416, Example 113 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 110 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279082&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273410 378160670 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045030 CCOc1ncccc1-c1cc(NCc2cnc(OC)cn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O2/c1-6-32-23-17(8-7-9-24-23)18-10-19(26-11-16-12-27-20(31-5)13-25-16)22-21(28-18)15(4)29-30(22)14(2)3/h7-10,12-14H,6,11H2,1-5H3,(H,26,28) QIWVSVNHRDQBOW-UHFFFAOYSA-N 279083 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(5-methoxypyrazin-2-yl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 114::US10512632, Example 114::US10766893, Example S114::US10806718, Example 114::US11026923, Example 114::US11491140, Example 114::US11634416, Example 114 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 24.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279083 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279083&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273413 378160671 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045033 CCOc1ncccc1-c1cc(NCc2cccnc2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H26N6O/c1-5-30-23-18(9-7-11-25-23)19-12-20(26-14-17-8-6-10-24-13-17)22-21(27-19)16(4)28-29(22)15(2)3/h6-13,15H,5,14H2,1-4H3,(H,26,27) MYYHBCJMEYIHMC-UHFFFAOYSA-N 279084 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(3-pyridylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 115::US10512632, Example 115::US10766893, Example S115::US10806718, Example 115::US11026923, Example 115::US11491140, Example 115::US11634416, Example 115 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 15.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279084&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273412 378160672 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045036 CCOc1ncccc1-c1cc(NCc2ccc(F)nc2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H25FN6O/c1-5-31-23-17(7-6-10-25-23)18-11-19(26-12-16-8-9-20(24)27-13-16)22-21(28-18)15(4)29-30(22)14(2)3/h6-11,13-14H,5,12H2,1-4H3,(H,26,28) SKXWAYULKGVUDE-UHFFFAOYSA-N 279085 5-(2-ethoxy-3-pyridyl)-N-[(6-fluoro-3-pyridyl)methyl]-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 116::US10512632, Example 116::US10766893, Example S116::US10806718, Example 116::US11026923, Example 116::US11491140, Example 116::US11634416, Example 116 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 21.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279085&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273414 378160673 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045039 CCOc1ncccc1-c1cc(NCc2ccc(nc2)C(F)F)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H26F2N6O/c1-5-33-24-17(7-6-10-27-24)19-11-20(22-21(30-19)15(4)31-32(22)14(2)3)29-13-16-8-9-18(23(25)26)28-12-16/h6-12,14,23H,5,13H2,1-4H3,(H,29,30) FDEJYPFAUDLEJD-UHFFFAOYSA-N 279086 N-[[6-(difluoromethyl)-3-pyridyl]methyl]-5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 117::US10512632, Example 117::US10766893, Example S117::US10806718, Example 117::US11026923, Example 117::US11491140, Example 117::US11634416, Example 117 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 18.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279086&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273416 378160674 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045042 CCOc1ncccc1-c1cc(NCc2ncccc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-17(9-7-12-26-24)18-13-19(27-14-20-21(31-5)10-8-11-25-20)23-22(28-18)16(4)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) CQZGCHPJVLXYPV-UHFFFAOYSA-N 279087 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(3-methoxy-2-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 118::US10512632, Example 118::US10766893, Example S118::US10806718, Example 118::US11026923, Example 118::US11491140, Example 118::US11634416, Example 118 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 13.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279087&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273417 378160675 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045045 CCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(nc(C)c2n1)C(C)CC 279088 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 119::US10034861, Example 120::US10512632, Example 120::US10618913, Example S120::US10766893, Example S120::US10806718, Example 120::US11026923, Example 120::US11634416, Example 120 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 12.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279088&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273415 378160676 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045048 CCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(nc(C)c2n1)C(C)CC 279088 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 119::US10034861, Example 120::US10512632, Example 120::US10618913, Example S120::US10766893, Example S120::US10806718, Example 120::US11026923, Example 120::US11634416, Example 120 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4.60 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279088&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273415 378160676 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045051 CCOc1ncccc1-c1cc(NCC(=N)\N=C/N)c(NC(C)CC)c(n1)C(C)=N InChI=1S/C21H30N8O/c1-5-13(3)28-20-17(26-11-18(24)27-12-22)10-16(29-19(20)14(4)23)15-8-7-9-25-21(15)30-6-2/h7-10,12-13,23,28H,5-6,11H2,1-4H3,(H,26,29)(H3,22,24,27) SBJLYMCDQIHVMN-UHFFFAOYSA-N 501491 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1- methylpropyl]-N-[(1-methyl-1,2,4-triazol-3- yl)methyl]pyrazolo[4,3-b]pyridin-7-amine, enantiomer 1::US11026923, Example 121::US11026923, Example 122 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4.00 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501491 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501491&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 155773342 459086731 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045054 CCOc1ncccc1-c1cc(NCC(=N)\N=C/N)c(NC(C)CC)c(n1)C(C)=N InChI=1S/C21H30N8O/c1-5-13(3)28-20-17(26-11-18(24)27-12-22)10-16(29-19(20)14(4)23)15-8-7-9-25-21(15)30-6-2/h7-10,12-13,23,28H,5-6,11H2,1-4H3,(H,26,29)(H3,22,24,27) SBJLYMCDQIHVMN-UHFFFAOYSA-N 501491 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1- methylpropyl]-N-[(1-methyl-1,2,4-triazol-3- yl)methyl]pyrazolo[4,3-b]pyridin-7-amine, enantiomer 1::US11026923, Example 121::US11026923, Example 122 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.20 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501491 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501491&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 155773342 459086731 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045057 CCOc1ncccc1-c1cc(NCc2nnc(C)o2)c(NC(C)CC)c(n1)C(C)=N InChI=1S/C22H29N7O2/c1-6-13(3)26-21-18(25-12-19-29-28-15(5)31-19)11-17(27-20(21)14(4)23)16-9-8-10-24-22(16)30-7-2/h8-11,13,23,26H,6-7,12H2,1-5H3,(H,25,27) SBMPCNJJGZDPRT-UHFFFAOYSA-N 501493 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(5-methyl- 1,3,4-oxadiazol-2-yl)methyl]-1-[1- methylpropyl]pyrazolo[4,3-b]pyridin-7-amine, enantiomer 1::US11026923, Example 123::US11026923, Example 124 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 54.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501493 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501493&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138746970 459086732 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045060 CCOc1ncccc1-c1cc(NCc2nnc(C)o2)c(NC(C)CC)c(n1)C(C)=N InChI=1S/C22H29N7O2/c1-6-13(3)26-21-18(25-12-19-29-28-15(5)31-19)11-17(27-20(21)14(4)23)16-9-8-10-24-22(16)30-7-2/h8-11,13,23,26H,6-7,12H2,1-5H3,(H,25,27) SBMPCNJJGZDPRT-UHFFFAOYSA-N 501493 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(5-methyl- 1,3,4-oxadiazol-2-yl)methyl]-1-[1- methylpropyl]pyrazolo[4,3-b]pyridin-7-amine, enantiomer 1::US11026923, Example 123::US11026923, Example 124 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 9.70 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501493 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501493&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138746970 459086732 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045063 CCOc1ncccc1-c1cc(NCc2cncc(OC)c2)c(NC(C)CC)c(n1)C(C)=N InChI=1S/C25H32N6O2/c1-6-16(3)30-24-22(29-14-18-11-19(32-5)15-27-13-18)12-21(31-23(24)17(4)26)20-9-8-10-28-25(20)33-7-2/h8-13,15-16,26,30H,6-7,14H2,1-5H3,(H,29,31) FIZYUMZEYFRNCJ-UHFFFAOYSA-N 501495 5-(2-ethoxy-3-pyridyl)-N-[(5-methoxy-3- pyridyl)methyl]-3-methyl-[1- methylpropyl]pyrazolo[4,3-b]pyridin-7-amine, enantiomer 2::US11026923, Example 125 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.000 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501495&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138746699 459086733 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045066 CCOc1ncccc1-c1cc(NCc2ccnc(OC)c2)c(NC(C)CC)c(n1)C(C)=N InChI=1S/C25H32N6O2/c1-6-16(3)30-24-21(29-15-18-10-12-27-22(13-18)32-5)14-20(31-23(24)17(4)26)19-9-8-11-28-25(19)33-7-2/h8-14,16,26,30H,6-7,15H2,1-5H3,(H,29,31) DUSGSRFZVDELPH-UHFFFAOYSA-N 501496 5-(2-ethoxy-3-pyridyl)-N-[(2-methoxy-4- pyridyl)methyl]-3-methyl-[1- methylpropyl]pyrazolo[4,3-b]pyridin-7-amine, enantiomer 2::US11026923, Example 126 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 5.40 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501496&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138746511 459086734 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045069 CCOc1ncccc1-c1cc(NCc2nnn(C)n2)c(NC(C)CC)c(n1)C(C)=N InChI=1S/C21H29N9O/c1-6-13(3)25-20-17(24-12-18-27-29-30(5)28-18)11-16(26-19(20)14(4)22)15-9-8-10-23-21(15)31-7-2/h8-11,13,22,25H,6-7,12H2,1-5H3,(H,24,26) KPXIVBJCVBNAQF-UHFFFAOYSA-N 501497 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1- methylpropyl]-N-[(2-methyltetrazol-5- yl)methyl]pyrazolo[4,3-b]pyridin-7-amine, enantiomer 2::US11026923, Example 127 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.80 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501497&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 155773321 459086735 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045072 CCOc1ncccc1-c1cc(NCc2noc(C)n2)c(NC(C)CC)c(n1)C(C)=N InChI=1S/C22H29N7O2/c1-6-13(3)26-21-18(25-12-19-27-15(5)31-29-19)11-17(28-20(21)14(4)23)16-9-8-10-24-22(16)30-7-2/h8-11,13,23,26H,6-7,12H2,1-5H3,(H,25,28) DFUHIVBKOGIXKT-UHFFFAOYSA-N 501498 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(5-methyl- 1,2,4-oxadiazol-3-yl)methyl]-1-[1- methylpropyl]pyrazolo[4,3-b]pyridin-7-amine, enantiomer 2::US11026923, Example 128 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.20 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501498 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501498&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138746781 459086736 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045075 CCOc1ncccc1-c1cc(NCc2coc(C)n2)c(NC(C)CC)c(n1)C(C)=N InChI=1S/C23H30N6O2/c1-6-14(3)27-22-20(26-12-17-13-31-16(5)28-17)11-19(29-21(22)15(4)24)18-9-8-10-25-23(18)30-7-2/h8-11,13-14,24,27H,6-7,12H2,1-5H3,(H,26,29) DEUYOHGQAHRUAK-UHFFFAOYSA-N 501499 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(2- methyloxazol-4-yl)methyl]-1-[1- methylpropyl]pyrazolo[4,3-b]pyridin-7-amine, enantiomer 2::US11026923, Example 129 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 11.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501499&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138746808 459086737 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045078 CCOc1ncccc1-c1cc(NCc2c[nH]cn2)c(NC(C)CC)c(n1)C(C)=N 501500 5-(2-ethoxy-3-pyridyl)-N-[1H-imidazol-4- ylmethyl)-3-methyl-1-[1- methylpropyl]pyrazolo[4,3-b]pyridin-7-amine, enantiomer 2::US11026923, Example 130 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 11.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501500&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138746776 459086738 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045081 CCOc1ncccc1-c1cc(NCc2cc(C)[nH]n2)c(NC(C)CC)c(n1)C(C)=N 501501 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1- methylpropyl]-N-[(5-methyl-1H-pyrazol-3- yl)methyl]pyrazolo[4,3-b]pyridin-7-amine, enantiomer 2::US11026923, Example 131 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.350 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501501&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 155773320 459086739 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045084 CCOc1ncccc1-c1cc(NCc2cn(C)cn2)c(NC(C)CC)c(n1)C(C)=N InChI=1S/C23H31N7O/c1-6-15(3)28-22-20(26-12-17-13-30(5)14-27-17)11-19(29-21(22)16(4)24)18-9-8-10-25-23(18)31-7-2/h8-11,13-15,24,28H,6-7,12H2,1-5H3,(H,26,29) OWQWYQRHXWXXOX-UHFFFAOYSA-N 501502 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[1- methylimidazol-4-yl)methyl]-1-[1- methylpropyl]pyrazolo[4,3-b]pyridin-7-amine, enantiomer 2::US11026923, Example 132 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.140 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501502&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138746516 459086740 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045087 CCOc1ncccc1-c1cc(NCc2cnc(C)o2)c(NC(C)CC)c(n1)C(C)=N InChI=1S/C23H30N6O2/c1-6-14(3)28-22-20(27-13-17-12-26-16(5)31-17)11-19(29-21(22)15(4)24)18-9-8-10-25-23(18)30-7-2/h8-12,14,24,28H,6-7,13H2,1-5H3,(H,27,29) DPLDHHPOPUXGGW-UHFFFAOYSA-N 501503 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(2- methyloxazol-5-yl)methyl]-1-[1- methylpropyl]pyrazolo[4,3-b]pyridin-7-amine, enantiomer 2::US11026923, Example 133 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 11.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501503 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501503&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138746911 459086741 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045090 CCCOc1ncccc1-c1cc(NCc2ncn(C)n2)c(NC(C)CC)c(n1)C(C)=N InChI=1S/C23H32N8O/c1-6-11-32-23-17(9-8-10-25-23)18-12-19(26-13-20-27-14-31(5)30-20)22(28-15(3)7-2)21(29-18)16(4)24/h8-10,12,14-15,24,28H,6-7,11,13H2,1-5H3,(H,26,29) XJUDCWZJLDFIBG-UHFFFAOYSA-N 501504 3-methyl-1-[1-methylpropyll-N-[(1-methyl- 1,2,4-triazol-3-yl)methyl]-5-(2-propoxy-3- pyridyl)pyrazolo[4,3-b]pyridin-7-amine, enantiomer 2::US11026923, Example 134 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.960 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501504&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138746812 459086742 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045093 CCCOc1ncccc1-c1cc(NCc2cc[nH]n2)c(NC(C)CC)c(n1)C(C)=N 501505 3-methyl-1-[1-methylpropyl]-5-(2-propoxy-3- pyridyl)-N-(1H-pyrazol-3- ylmethyl)pyrazolo[4,3-b]pyridin-7-amine, enantiomer 2::US11026923, Example 135 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.90 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501505 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501505&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138746983 459086743 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045096 CCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(ncc2n1)C(C)CC 279105 5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine, enantiomer 1::US10034861, Example 136::US10034861, Example 137::US10512632, Example 137::US10766893, Example S137::US10806718, Example 137::US11026923, Example 137::US11491140, Example 137::US11634416, Example 137 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 62.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279105&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273431 378160690 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045099 CCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(ncc2n1)C(C)CC 279105 5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine, enantiomer 1::US10034861, Example 136::US10034861, Example 137::US10512632, Example 137::US10766893, Example S137::US10806718, Example 137::US11026923, Example 137::US11491140, Example 137::US11634416, Example 137 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 180 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279105&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273431 378160690 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045102 CCOc1ncccc1-c1cc(NCc2nnc(C)o2)c2n(ncc2n1)C(C)CC InChI=1S/C21H25N7O2/c1-5-13(3)28-20-17(23-12-19-27-26-14(4)30-19)10-16(25-18(20)11-24-28)15-8-7-9-22-21(15)29-6-2/h7-11,13H,5-6,12H2,1-4H3,(H,23,25) BIQGCKNODPBTSC-UHFFFAOYSA-N 279107 5-(2-ethoxy-3-pyridyl)-N-[(5-methyl-1,3,4-oxadiazol-2-yl)methyl]-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 138::US10034861, Example 139::US10512632, Example 139::US10766893, Example S139::US10806718, Example 139::US11026923, Example 139::US11491140, Example 139::US11634416, Example 139 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 93.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279107&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273432 378160691 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045105 CCOc1ncccc1-c1cc(NCc2nnc(C)o2)c2n(ncc2n1)C(C)CC InChI=1S/C21H25N7O2/c1-5-13(3)28-20-17(23-12-19-27-26-14(4)30-19)10-16(25-18(20)11-24-28)15-8-7-9-22-21(15)29-6-2/h7-11,13H,5-6,12H2,1-4H3,(H,23,25) BIQGCKNODPBTSC-UHFFFAOYSA-N 279107 5-(2-ethoxy-3-pyridyl)-N-[(5-methyl-1,3,4-oxadiazol-2-yl)methyl]-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 138::US10034861, Example 139::US10512632, Example 139::US10766893, Example S139::US10806718, Example 139::US11026923, Example 139::US11491140, Example 139::US11634416, Example 139 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 330 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279107&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273432 378160691 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045108 CCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(ncc2n1)C(C)CC InChI=1S/C21H26N8O/c1-5-14(3)29-20-17(23-12-19-24-13-28(4)27-19)10-16(26-18(20)11-25-29)15-8-7-9-22-21(15)30-6-2/h7-11,13-14H,5-6,12H2,1-4H3,(H,23,26) OKQUCPHNAVGTKM-UHFFFAOYSA-N 279109 5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 140::US10034861, Example 141::US10512632, Example 141::US10766893, Example S141::US10806718, Example 141::US11026923, Example 141::US11491140, Example 141::US11634416, Example 141 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 32.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279109&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273433 378160692 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045111 CCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(ncc2n1)C(C)CC InChI=1S/C21H26N8O/c1-5-14(3)29-20-17(23-12-19-24-13-28(4)27-19)10-16(26-18(20)11-25-29)15-8-7-9-22-21(15)30-6-2/h7-11,13-14H,5-6,12H2,1-4H3,(H,23,26) OKQUCPHNAVGTKM-UHFFFAOYSA-N 279109 5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 140::US10034861, Example 141::US10512632, Example 141::US10766893, Example S141::US10806718, Example 141::US11026923, Example 141::US11491140, Example 141::US11634416, Example 141 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 44.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279109&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273433 378160692 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045114 CCCOc1ncccc1-c1cc(NCc2cn(C)cn2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C24H31N7O/c1-6-11-32-24-19(9-8-10-25-24)20-12-21(26-13-18-14-30(5)15-27-18)23-22(28-20)17(4)29-31(23)16(3)7-2/h8-10,12,14-16H,6-7,11,13H2,1-5H3,(H,26,28) SJMDRHYXKHAMKH-UHFFFAOYSA-N 501512 1-isopropyl-3-methyl-N-[(1-methylimidazol-4- yl)methyl]-5-(2-propoxy-3- pyridyl)pyrazolo[4,3-b]pyridin-7-amine::US11026923, Example 142 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.260 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501512 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501512&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 155773337 459086744 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045117 CCCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H27N7O/c1-5-11-30-22-17(7-6-9-23-22)18-12-19(24-13-16-8-10-25-27-16)21-20(26-18)15(4)28-29(21)14(2)3/h6-10,12,14H,5,11,13H2,1-4H3,(H,24,26)(H,25,27) WVFCCHYAETYKIF-UHFFFAOYSA-N 279112 1-isopropyl-3-methyl-5-(2-propoxy-3-pyridyl)-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 143::US10512632, Example 143::US10766893, Example S143::US10806718, Example 143::US11026923, Example 143::US11491140, Example 143::US11634416, Example 143 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 3.80 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279112&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273435 378160694 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045120 CCOc1ncccc1-c1cc(NCc2nc[nH]n2)c2n(nc(C)c2n1)C(C)CC 279113 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]-N-(1H-1,2,4-triazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 144::US10512632, Example 144::US10766893, Example S144::US10806718, Example 144::US11026923, Example 144::US11491140, Example 144::US11634416, Example 144 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 14.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279113&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273438 378160695 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045123 CCCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H28N8O/c1-6-10-31-22-16(8-7-9-23-22)17-11-18(24-12-19-25-13-29(5)28-19)21-20(26-17)15(4)27-30(21)14(2)3/h7-9,11,13-14H,6,10,12H2,1-5H3,(H,24,26) ROWMNTAKQCZGNZ-UHFFFAOYSA-N 279114 1-isopropyl-3-methyl-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]-5-(2-propoxy-3-pyridyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 145::US10512632, Example 145::US10766893, Example S145::US10806718, Example 145::US11026923, Example 145::US11491140, Example 145::US11634416, Example 145 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.410 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279114&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273436 378160696 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045126 CCCOc1ncccc1-c1cc(NCc2nc[nH]n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-5-9-30-21-15(7-6-8-22-21)16-10-17(23-11-18-24-12-25-27-18)20-19(26-16)14(4)28-29(20)13(2)3/h6-8,10,12-13H,5,9,11H2,1-4H3,(H,23,26)(H,24,25,27) RLGQIPCFRYRCDL-UHFFFAOYSA-N 279115 1-isopropyl-3-methyl-5-(2-propoxy-3-pyridyl)-N-(1H-1,2,4-triazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 146::US10512632, Example 146::US10766893, Example S146::US10806718, Example 146::US11026923, Example 146::US11491140, Example 146::US11634416, Example 146 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 3.90 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279115&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273440 378160697 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045129 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1nccs1 InChI=1S/C18H21N7S/c1-11(2)25-17-14(20-8-13-9-21-24(4)10-13)7-15(18-19-5-6-26-18)22-16(17)12(3)23-25/h5-7,9-11H,8H2,1-4H3,(H,20,22) TVGMRVMYCDHOEG-UHFFFAOYSA-N 279116 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-thiazol-2-yl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 147::US10512632, Example 147::US10618913, Example S147::US10766893, Example S147::US10806718, Example 147::US11026923, Example 147::US11491140, Example 147::US11634416, Example 147 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 12.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279116&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273437 378160698 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045132 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1ncc(C)s1 InChI=1S/C19H23N7S/c1-11(2)26-18-15(20-8-14-9-22-25(5)10-14)6-16(19-21-7-12(3)27-19)23-17(18)13(4)24-26/h6-7,9-11H,8H2,1-5H3,(H,20,23) ACZBEPYVSHJPFB-UHFFFAOYSA-N 279117 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-(5-methylthiazol-2-yl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 148::US10512632, Example 148::US10766893, Example S148::US10806718, Example 148::US11026923, Example 148::US11491140, Example 148::US11634416, Example 148 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 110 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279117&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273439 378160699 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045135 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1nc(C)cs1 InChI=1S/C19H23N7S/c1-11(2)26-18-15(20-7-14-8-21-25(5)9-14)6-16(19-22-12(3)10-27-19)23-17(18)13(4)24-26/h6,8-11H,7H2,1-5H3,(H,20,23) HCLONMUJAHJFIH-UHFFFAOYSA-N 279118 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-(4-methylthiazol-2-yl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 149::US10512632, Example 149::US10766893, Example S149::US10806718, Example 149::US11026923, Example 149::US11491140, Example 149::US11634416, Example 149 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 29.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279118&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273441 378160700 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045138 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)N1CC(C)OC1=O InChI=1S/C19H25N7O2/c1-11(2)26-18-15(20-7-14-8-21-24(5)10-14)6-16(22-17(18)13(4)23-26)25-9-12(3)28-19(25)27/h6,8,10-12H,7,9H2,1-5H3,(H,20,22) YBJPEIIVVVNBPC-UHFFFAOYSA-N 279119 3-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]-5-methyl-oxazolidin-2-one::US10034861, Example 150::US10512632, Example 150::US10766893, Example S150::US10806718, Example 150::US11026923, Example 150::US11491140, Example 150::US11634416, Example 150 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 44.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279119&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273442 378160701 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045141 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)N1CCOC1=O InChI=1S/C18H23N7O2/c1-11(2)25-17-14(19-8-13-9-20-23(4)10-13)7-15(21-16(17)12(3)22-25)24-5-6-27-18(24)26/h7,9-11H,5-6,8H2,1-4H3,(H,19,21) CBOOBJUJEUVRPS-UHFFFAOYSA-N 279120 3-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]oxazolidin-2-one::US10034861, Example 151::US10512632, Example 151::US10766893, Example S151::US10806718, Example 151::US11026923, Example 151::US11491140, Example 151::US11634416, Example 151 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 10.00 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279120&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273443 378160702 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045144 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)N1CCC1=O InChI=1S/C18H23N7O/c1-11(2)25-18-14(19-8-13-9-20-23(4)10-13)7-15(24-6-5-16(24)26)21-17(18)12(3)22-25/h7,9-11H,5-6,8H2,1-4H3,(H,19,21) SLJWZSCTWDVJBR-UHFFFAOYSA-N 279121 1-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]azetidin-2-one::US10034861, Example 152::US10512632, Example 152::US10766893, Example S152::US10806718, Example 152::US11026923, Example 152::US11491140, Example 152::US11634416, Example 152 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 48.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279121&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273444 378160703 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045147 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)N1CCN(C1=O)C(C)(C)C InChI=1S/C22H32N8O/c1-14(2)30-20-17(23-11-16-12-24-27(7)13-16)10-18(25-19(20)15(3)26-30)28-8-9-29(21(28)31)22(4,5)6/h10,12-14H,8-9,11H2,1-7H3,(H,23,25) KIFHGJKUXDTDBI-UHFFFAOYSA-N 279122 1-tert-butyl-3-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]imidazolidin-2-one::US10034861, Example 153::US10512632, Example 153::US10766893, Example S153::US10806718, Example 153::US11026923, Example 153::US11491140, Example 153::US11634416, Example 153 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 130 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279122&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273445 378160704 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045150 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)N1CCCC1=O InChI=1S/C19H25N7O/c1-12(2)26-19-15(20-9-14-10-21-24(4)11-14)8-16(22-18(19)13(3)23-26)25-7-5-6-17(25)27/h8,10-12H,5-7,9H2,1-4H3,(H,20,22) CXGJWWJDXYZFFZ-UHFFFAOYSA-N 279123 1-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]pyrrolidin-2-one::US10034861, Example 154::US10512632, Example 154::US10766893, Example S154::US10806718, Example 154::US11026923, Example 154::US11491140, Example 154::US11634416, Example 154 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 26.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279123&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273446 378160705 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045153 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)N1C(C)COC1=O InChI=1S/C19H25N7O2/c1-11(2)26-18-15(20-7-14-8-21-24(5)9-14)6-16(22-17(18)13(4)23-26)25-12(3)10-28-19(25)27/h6,8-9,11-12H,7,10H2,1-5H3,(H,20,22) DXKZTPARVQEQMA-UHFFFAOYSA-N 279124 3-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]-4-methyl-oxazolidin-2-one::US10034861, Example 155::US10512632, Example 155::US10766893, Example S155::US10806718, Example 155::US11026923, Example 155::US11491140, Example 155::US11634416, Example 155 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.20 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279124&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273447 378160706 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045156 CCC1COC(=O)N1c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C20H27N7O2/c1-6-15-11-29-20(28)26(15)17-7-16(21-8-14-9-22-25(5)10-14)19-18(23-17)13(4)24-27(19)12(2)3/h7,9-10,12,15H,6,8,11H2,1-5H3,(H,21,23) CVOILQIVJFYVAQ-UHFFFAOYSA-N 279125 4-ethyl-3-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]oxazolidin-2-one::US10034861, Example 156::US10512632, Example 156::US10766893, Example S156::US10806718, Example 156::US11026923, Example 156::US11491140, Example 156::US11634416, Example 156 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 31.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279125&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273448 378160707 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045159 CCOc1ncccc1-c1cc(CNc2cncc(OC)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-20(8-7-9-26-24)21-10-17(12-27-18-11-19(31-5)14-25-13-18)23-22(28-21)16(4)29-30(23)15(2)3/h7-11,13-15,27H,6,12H2,1-5H3 BXZMPJVMGAVKJS-UHFFFAOYSA-N 279126 N-[[5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-yl]methyl]-5-methoxy-pyridin-3-amine::US10034861, Example 157::US10512632, Example 157::US10766893, Example S157::US10806718, Example 157::US11026923, Example 157::US11491140, Example 157::US11634416, Example 157 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 34.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279126&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273449 378160708 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045162 CCOc1ncccc1-c1cc(CNc2ncn(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-6-30-20-16(8-7-9-22-20)17-10-15(11-23-21-24-12-28(5)27-21)19-18(25-17)14(4)26-29(19)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,23,27) XUAILHHYTLESDG-UHFFFAOYSA-N 279127 N-[[5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-yl]methyl]-1-methyl-1,2,4-triazol-3-amine::US10034861, Example 158::US10512632, Example 158::US10766893, Example S158::US10806718, Example 158::US11026923, Example 158::US11491140, Example 158::US11634416, Example 158 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 23.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279127&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273450 378160709 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045165 CCOc1ncccc1-c1cc(CCc2cncc(OC)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C25H29N5O2/c1-6-32-25-21(8-7-11-27-25)22-13-19(10-9-18-12-20(31-5)15-26-14-18)24-23(28-22)17(4)29-30(24)16(2)3/h7-8,11-16H,6,9-10H2,1-5H3 KRADQTILGMSJGT-UHFFFAOYSA-N 279128 5-(2-ethoxy-3-pyridyl)-1-isopropyl-7-[2-(5-methoxy-3-pyridyl)ethyl]-3-methyl-pyrazolo[4,3-b]pyridine::US10034861, Example 159::US10512632, Example 159::US10766893, Example S159::US10806718, Example 159::US11026923, Example 159::US11491140, Example 159::US11634416, Example 159 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 270 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279128&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273451 378160710 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045168 CCOc1ncccc1-c1cc(CCc2ncn(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H27N7O/c1-6-30-22-17(8-7-11-23-22)18-12-16(9-10-19-24-13-28(5)27-19)21-20(25-18)15(4)26-29(21)14(2)3/h7-8,11-14H,6,9-10H2,1-5H3 DQKKFAGODSQYOO-UHFFFAOYSA-N 279129 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-7-[2-(1-methyl-1,2,4-triazol-3-yl)ethyl]pyrazolo[4,3-b]pyridine::US10034861, Example 160::US10512632, Example 160::US10766893, Example S160::US10806718, Example 160::US11026923, Example 160::US11491140, Example 160::US11634416, Example 160 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 23.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279129&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273452 378160711 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045171 CCOc1ncccc1-c1cc(NCc2ncnn2C)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-6-30-21-15(8-7-9-22-21)16-10-17(23-11-18-24-12-25-28(18)5)20-19(26-16)14(4)27-29(20)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,23,26) DSJWNAKWTOCISO-UHFFFAOYSA-N 425070 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methyl-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10512632, Example 161::US10618913, Example S161::US10766893, Example S161::US10806718, Example 161::US11026923, Example 161::US11491140, Example 162::US11634416, Example 161 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 60.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=425070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=425070&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138536279 434150493 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045174 CCOc1ncccc1-c1cc(NCc2nncn2C)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-6-30-21-15(8-7-9-22-21)16-10-17(23-11-18-26-24-12-28(18)5)20-19(25-16)14(4)27-29(20)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,23,25) XEGYXYUUSUWLRL-UHFFFAOYSA-N 279131 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(4-methyl-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 162::US10512632, Example 162::US10766893, Example S162::US11026923, Example 162::US11634416, Example 162 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 100.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279131&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273453 378160712 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045177 CCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(nc(C)c2n1)C1COC1 InChI=1S/C21H24N8O2/c1-4-31-21-15(6-5-7-22-21)16-8-17(23-9-18-24-12-28(3)27-18)20-19(25-16)13(2)26-29(20)14-10-30-11-14/h5-8,12,14H,4,9-11H2,1-3H3,(H,23,25) KHCSAUOHEOUDEI-UHFFFAOYSA-N 279132 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]-1-(oxetan-3-yl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 163::US10512632, Example 163::US10618913, Example S163::US10766893, Example S163::US10806718, Example 163::US11026923, Example 163::US11491140, Example 163::US11634416, Example 163 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 120 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279132&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273457 378160713 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045180 CCOc1ncccc1-c1cc(SCCC(=O)OCC(C)C)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H32N4O3S/c1-7-30-24-18(9-8-11-25-24)19-13-20(32-12-10-21(29)31-14-15(2)3)23-22(26-19)17(6)27-28(23)16(4)5/h8-9,11,13,15-16H,7,10,12,14H2,1-6H3 HVDCJFCTBUPVCE-UHFFFAOYSA-N 279133 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylsulfanyl]pyrazolo[4,3-b]pyridine::US10034861, Example 164::US10806718, Example 164::US11026923, Example 164::US11491140, Example 164::US11634416, Example 164 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 6.80 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279133&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273278 378160714 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045183 CCOc1ncccc1-c1cc(N(Cc2cnn(c2)C(F)F)Cc2ccc(OC)cc2)c2n(nc(C)c2n1)C(C)C InChI=1S/C30H33F2N7O2/c1-6-41-29-24(8-7-13-33-29)25-14-26(28-27(35-25)20(4)36-39(28)19(2)3)37(16-21-9-11-23(40-5)12-10-21)17-22-15-34-38(18-22)30(31)32/h7-15,18-19,30H,6,16-17H2,1-5H3 UXTFTMXAFOTATJ-UHFFFAOYSA-N 279134 N-[[1-(difluoromethyl)pyrazol-4-yl]methyl]-5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 165::US10512632, Example 165::US10618913, Example S165::US11026923, Example 165::US11491140, Example 165::US11634416, Example 165 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 73.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279134&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273284 378160715 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045186 CCOc1ncccc1-c1cc(NCc2cc(CF)on2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H25FN6O2/c1-5-30-22-17(7-6-8-24-22)18-10-19(25-12-15-9-16(11-23)31-28-15)21-20(26-18)14(4)27-29(21)13(2)3/h6-10,13H,5,11-12H2,1-4H3,(H,25,26) XUHFADCPGYKQAR-UHFFFAOYSA-N 279135 5-(2-ethoxy-3-pyridyl)-N-[[5-(fluoromethyl)isoxazol-3-yl]methyl]-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::BDBM425076::US10034861, Example 166::US10512632, Example 166::US10766893, Example S166::US10806718, Example 166::US11026923, Example 166::US11491140, Example 166::US11634416, Example 166 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.10 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279135&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273459 378160716 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045189 CCOc1ncccc1-c1cc(NCc2cc(CF)no2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H25FN6O2/c1-5-30-22-17(7-6-8-24-22)18-10-19(25-12-16-9-15(11-23)28-31-16)21-20(26-18)14(4)27-29(21)13(2)3/h6-10,13H,5,11-12H2,1-4H3,(H,25,26) VTULNMARMGUDCN-UHFFFAOYSA-N 279136 5-(2-ethoxy-3-pyridyl)-N-[[3-(fluoromethyl)isoxazol-5-yl]methyl]-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 167::US10766893, Example S167::US10806718, Example 167::US11026923, Example 167::US11491140, Example 167::US11634416, Example 167 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 11.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279136&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273460 378160717 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045192 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1ncco1 InChI=1S/C18H21N7O/c1-11(2)25-17-14(20-8-13-9-21-24(4)10-13)7-15(18-19-5-6-26-18)22-16(17)12(3)23-25/h5-7,9-11H,8H2,1-4H3,(H,20,22) IMKYKBMLZRNQRQ-UHFFFAOYSA-N 279137 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-oxazol-2-yl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 168::US10512632, Example 168::US10618913, Example S168::US10766893, Example S168::US10806718, Example 168::US11026923, Example 168::US11491140, Example 168::US11634416, Example 168 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 14.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279137&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273461 378160718 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045195 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1cnnn1C InChI=1S/C18H23N9/c1-11(2)27-18-15(19-7-13-8-21-25(4)10-13)6-14(16-9-20-24-26(16)5)22-17(18)12(3)23-27/h6,8-11H,7H2,1-5H3,(H,19,22) YPYKZBZKFWCVCN-UHFFFAOYSA-N 279138 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-(3-methyltriazol-4-yl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 169::US10512632, Example 169::US10618913, Example S169::US10766893, Example S169::US10806718, Example 169::US11026923, Example 169::US11491140, Example 169::US11634416, Example 169 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 610 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279138&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273462 378160719 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045198 COc1ncccc1-c1cc(NCc2cccnc2C(F)(F)F)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H23F3N6O/c1-13(2)32-20-18(29-12-15-7-5-9-27-21(15)23(24,25)26)11-17(30-19(20)14(3)31-32)16-8-6-10-28-22(16)33-4/h5-11,13H,12H2,1-4H3,(H,29,30) GLFDPBHOMZCMEF-UHFFFAOYSA-N 279139 1-isopropyl-5-(2-methoxy-3-pyridyl)-3-methyl-N-[[2-(trifluoromethyl)-3-pyridyl]methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 170::US10512632, Example 170::US10766893, Example S170::US10806718, Example 170::US11026923, Example 170::US11491140, Example 170::US11634416, Example 170 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 42.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279139&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273463 378160720 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045201 COc1ncccc1CNc1cc(nc2c(C)nn(C(C)C)c12)-c1ccc[nH]c1=O InChI=1S/C22H24N6O2/c1-13(2)28-20-18(25-12-15-7-5-10-24-22(15)30-4)11-17(26-19(20)14(3)27-28)16-8-6-9-23-21(16)29/h5-11,13H,12H2,1-4H3,(H,23,29)(H,25,26) YJCZMNIYQABZMT-UHFFFAOYSA-N 279140 3-[1-isopropyl-7-[(2-methoxy-3-pyridyl)methylamino]-3-methyl-pyrazolo[4,3-b]pyridin-5-yl]-1H-pyridin-2-one::US10034861, Example 171::US10512632, Example 171::US10766893, Example S171::US10806718, Example 171::US11026923, Example 171::US11491140, Example 171::US11634416, Example 171 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 290 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279140 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279140&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 136214892 378160721 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045204 CCOc1ncccc1-c1cc(NCc2ccncc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(8-7-10-26-24)19-12-20(27-13-17-9-11-25-14-21(17)31-5)23-22(28-19)16(4)29-30(23)15(2)3/h7-12,14-15H,6,13H2,1-5H3,(H,27,28) ZDNREOIUOKDWKN-UHFFFAOYSA-N 425081 US10512632, Example 172::US10766893, Example S172::US10806718, Example 172::US11026923, Example 172::US11491140, Example 172::US11634416, Example 172 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 40.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=425081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=425081&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138535948 434150496 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045207 COc1ncccc1-c1cc(NCc2cnc(C)s2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H24N6OS/c1-12(2)27-20-18(24-11-15-10-23-14(4)29-15)9-17(25-19(20)13(3)26-27)16-7-6-8-22-21(16)28-5/h6-10,12H,11H2,1-5H3,(H,24,25) SVOMGFJYTSFSPH-UHFFFAOYSA-N 279142 1-isopropyl-5-(2-methoxy-3-pyridyl)-3-methyl-N-[(2-methylthiazol-5-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 173::US10512632, Example 173::US10766893, Example S173::US11026923, Example 173::US11491140, Example 173::US11634416, Example 173 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 49.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279142&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273465 378160722 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045210 COc1ncccc1CNc1cc(nc2c(C)nn(C(C)C)c12)-c1cccnc1OC1CC1 InChI=1S/C25H28N6O2/c1-15(2)31-23-21(28-14-17-7-5-11-26-24(17)32-4)13-20(29-22(23)16(3)30-31)19-8-6-12-27-25(19)33-18-9-10-18/h5-8,11-13,15,18H,9-10,14H2,1-4H3,(H,28,29) QLFKDVQWAWXRKU-UHFFFAOYSA-N 279143 5-(2-cyclopropoxypyridin-3-yl)-1-isopropyl-N-((2-methoxypyridin-3-yl)methyl)-3-methyl-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 174::US10512632, Example 174::US10766893, Example S174::US10806718, Example 174::US11026923, Example 174::US11491140, Example 174::US11634416, Example 174 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 18.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279143 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279143&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273466 378160723 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045213 COc1ncccc1CNc1cc(nc2c(C)nn(C(C)C)c12)-c1ccnn1C InChI=1S/C21H25N7O/c1-13(2)28-20-17(23-12-15-7-6-9-22-21(15)29-5)11-16(18-8-10-24-27(18)4)25-19(20)14(3)26-28/h6-11,13H,12H2,1-5H3,(H,23,25) CROUXODBTXNMIZ-UHFFFAOYSA-N 279144 1-isopropyl-N-((2-methoxypyridin-3-yl)methyl)-3-methyl-5-(1-methyl-1H-pyrazol-5-yl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 175::US10512632, Example 175::US10766893, Example S175::US10806718, Example 175::US11026923, Example 175::US11491140, Example 175::US11634416, Example 175 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 83.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279144&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273467 378160724 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045216 CCOc1ncccc1-c1cc(NCc2ncc(OC)cn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O2/c1-6-32-23-17(8-7-9-24-23)18-10-19(25-13-20-26-11-16(31-5)12-27-20)22-21(28-18)15(4)29-30(22)14(2)3/h7-12,14H,6,13H2,1-5H3,(H,25,28) NLZDQEYNQWGPGP-UHFFFAOYSA-N 279145 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(5-methoxypyrimidin-2-yl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 176::US10512632, Example 176::US10766893, Example S176::US10806718, Example 176::US11026923, Example 176::US11491140, Example 176::US11634416, Example 176 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 81.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279145&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273468 378160725 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045219 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1ccc[nH]c1=O InChI=1S/C20H23N7O/c1-12(2)27-19-17(22-9-14-10-23-26(4)11-14)8-16(24-18(19)13(3)25-27)15-6-5-7-21-20(15)28/h5-8,10-12H,9H2,1-4H3,(H,21,28)(H,22,24) ZZXWQIDOSVIHIM-UHFFFAOYSA-N 279146 3-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]-1H-pyridin-2-one::US10034861, Example 177::US10512632, Example 177::US10766893, Example S177::US10806718, Example 177::US11026923, Example 177::US11491140, Example 177::US11634416, Example 177 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 130 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279146&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 136214893 378160726 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045222 CCOc1ncccc1-c1cc(NCc2cccnc2C(F)F)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H26F2N6O/c1-5-33-24-17(9-7-11-28-24)18-12-19(22-20(30-18)15(4)31-32(22)14(2)3)29-13-16-8-6-10-27-21(16)23(25)26/h6-12,14,23H,5,13H2,1-4H3,(H,29,30) IRSHUSVLDQPATB-UHFFFAOYSA-N 279147 N-[[2-(difluoromethyl)-3-pyridyl]methyl]-5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 178::US10512632, Example 178::US10766893, Example S178::US10806718, Example 178::US11026923, Example 178::US11491140, Example 178::US11634416, Example 178 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 31.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279147&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273469 378160727 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045225 CCOc1ncccc1-c1cc(NCc2cc(OC)ncn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O2/c1-6-32-23-17(8-7-9-24-23)18-11-19(25-12-16-10-20(31-5)27-13-26-16)22-21(28-18)15(4)29-30(22)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,25,28) RTCQCKBUFIYEDZ-UHFFFAOYSA-N 279148 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(6-methoxypyrimidin-4-yl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 179::US10512632, Example 179::US10766893, Example S179::US10806718, Example 179::US11026923, Example 179::US11491140, Example 179::US11634416, Example 179 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.80 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279148&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273471 378160728 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045228 CCOc1ncccc1-c1cc(NCc2cccnc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(10-8-12-26-24)19-13-20(27-14-17-9-7-11-25-23(17)31-5)22-21(28-19)16(4)29-30(22)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) LOZUTDKVJLMDTB-UHFFFAOYSA-N 279055 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 172::US10034861, Example 180::US10034861, Example 181::US10034861, Example 182::US10034861, Example 86::US10512632, Example 86::US10766893, Example S86::US10806718, Example 182::US11026923, Example 182::US11491140, Example 86::US11634416, Example 86 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 27.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279055&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273386 378160643 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045231 CCOc1ncccc1-c1cc(NCc2cccnc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(10-8-12-26-24)19-13-20(27-14-17-9-7-11-25-23(17)31-5)22-21(28-19)16(4)29-30(22)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) LOZUTDKVJLMDTB-UHFFFAOYSA-N 279055 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 172::US10034861, Example 180::US10034861, Example 181::US10034861, Example 182::US10034861, Example 86::US10512632, Example 86::US10766893, Example S86::US10806718, Example 182::US11026923, Example 182::US11491140, Example 86::US11634416, Example 86 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 31.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279055&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273386 378160643 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045234 CCOc1ncccc1-c1cc(NCc2cccnc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(10-8-12-26-24)19-13-20(27-14-17-9-7-11-25-23(17)31-5)22-21(28-19)16(4)29-30(22)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) LOZUTDKVJLMDTB-UHFFFAOYSA-N 279055 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 172::US10034861, Example 180::US10034861, Example 181::US10034861, Example 182::US10034861, Example 86::US10512632, Example 86::US10766893, Example S86::US10806718, Example 182::US11026923, Example 182::US11491140, Example 86::US11634416, Example 86 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 24.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279055&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273386 378160643 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045237 COc1ncccc1CNc1cc(nc2c(C)nn(C(C)C)c12)C(=C\C=C)\C(=N)C(F)(F)F InChI=1S/C23H25F3N6O/c1-6-8-16(21(27)23(24,25)26)17-11-18(29-12-15-9-7-10-28-22(15)33-5)20-19(30-17)14(4)31-32(20)13(2)3/h6-11,13,27H,1,12H2,2-5H3,(H,29,30)/b16-8-,27-21? OJTUUGACOKQJNT-QHMQWLFDSA-N 501554 1-isopropyl-N-((2-methoxypyridin-3- y)methyl)-3-methyl-5-(2- (trifluoromethyl)pyridin-3-yl)-1H-pyrazolo[4,3- b]pyridin-7-amine::US11026923, Example 183::US11491140, Example 183 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 290 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501554 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501554&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 155642144 459086745 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045240 CCOc1ncccc1-c1cc(NCc2cn[nH]c2)c(NC(C)C)c(n1)C(=N)CC(F)F InChI=1S/C22H27F2N7O/c1-4-32-22-15(6-5-7-26-22)17-9-18(27-10-14-11-28-29-12-14)21(30-13(2)3)20(31-17)16(25)8-19(23)24/h5-7,9,11-13,19,25,30H,4,8,10H2,1-3H3,(H,27,31)(H,28,29) MLGGVHCQGVZWQR-UHFFFAOYSA-N 501555 3-(difluoromethyl)-5-(2-ethoxypyridin-3-yl)-1- isopropyl-N-((1-methyl-1H-pyrazol-4- yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US11026923, Example 184 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 13.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501555&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 155773338 459086746 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045243 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-n1cncn1 InChI=1S/C17H21N9/c1-11(2)26-17-14(19-6-13-7-20-24(4)8-13)5-15(25-10-18-9-21-25)22-16(17)12(3)23-26/h5,7-11H,6H2,1-4H3,(H,19,22) VELNJFTUSCXPKE-UHFFFAOYSA-N 279154 1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-5-(1H-1,2,4-triazol-1-yl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 185::US10512632, Example 185::US10766893, Example S185::US10806718, Example 185::US11026923, Example 185::US11491140, Example 185::US11634416, Example 185 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 100.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279154&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273474 378160731 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045246 CC(C)n1nc(C)c2nc(cc(NCc3ncn(C)n3)c12)-c1ccc[nH]c1=O InChI=1S/C19H22N8O/c1-11(2)27-18-15(21-9-16-22-10-26(4)25-16)8-14(23-17(18)12(3)24-27)13-6-5-7-20-19(13)28/h5-8,10-11H,9H2,1-4H3,(H,20,28)(H,21,23) LRKYMHYCQWOGDT-UHFFFAOYSA-N 279155 3-[1-isopropyl-3-methyl-7-[(1-methyl-1,2,4-triazol-3-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]-1H-pyridin-2-one::US10034861, Example 186::US10512632, Example 186::US10766893, Example S186::US10806718, Example 186::US11026923, Example 186::US11491140, Example 186::US11634416, Example 186 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 64.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279155&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 136214894 378160732 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045249 CC(C)n1nc(C)c2nc(cc(NCc3cc[nH]n3)c12)-c1ccc[nH]c1=O InChI=1S/C19H21N7O/c1-11(2)26-18-16(21-10-13-6-8-22-24-13)9-15(23-17(18)12(3)25-26)14-5-4-7-20-19(14)27/h4-9,11H,10H2,1-3H3,(H,20,27)(H,21,23)(H,22,24) FWAXXZSYYYRIBS-UHFFFAOYSA-N 279156 3-[1-isopropyl-3-methyl-7-(1H-pyrazol-3-ylmethylamino)pyrazolo[4,3-b]pyridin-5-yl]-1H-pyridin-2-one::US10034861, Example 187::US10512632, Example 187::US10766893, Example S187::US10806718, Example 187::US11026923, Example 187::US11491140, Example 187::US11634416, Example 187 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 140 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279156&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 136214895 378160733 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045252 COc1ncccc1CNc1cc(nc2c(C)nn(C(C)C)c12)-c1cccnc1OC(F)F InChI=1S/C23H24F2N6O2/c1-13(2)31-20-18(28-12-15-7-5-9-26-21(15)32-4)11-17(29-19(20)14(3)30-31)16-8-6-10-27-22(16)33-23(24)25/h5-11,13,23H,12H2,1-4H3,(H,28,29) HFYVDFFGOVRRIK-UHFFFAOYSA-N 279157 5-[2-(difluoromethoxy)-3-pyridyl]-1-isopropyl-N-[(2-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 188::US10512632, Example 188::US10766893, Example S188::US11026923, Example 188::US11491140, Example 188::US11634416, Example 188 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 61.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279157&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273478 378160734 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045255 CCOc1ncccc1-c1cc(NCc2nccc(OC)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O2/c1-6-32-23-16(8-7-10-25-23)17-12-18(26-13-19-24-11-9-20(28-19)31-5)22-21(27-17)15(4)29-30(22)14(2)3/h7-12,14H,6,13H2,1-5H3,(H,26,27) ZRCQWXKCYCHOGM-UHFFFAOYSA-N 279158 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(4-methoxypyrimidin-2-yl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 189::US10512632, Example 189::US10766893, Example S189::US10806718, Example 189::US11026923, Example 189::US11491140, Example 189::US11634416, Example 189 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 3.90 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279158&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273477 378160735 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045258 CCOc1ncccc1-c1cc(NCc2cncnc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O2/c1-6-32-23-17(8-7-9-25-23)18-10-19(26-12-16-11-24-13-27-22(16)31-5)21-20(28-18)15(4)29-30(21)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,26,28) FQSCOMBJMAVYMG-UHFFFAOYSA-N 279159 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(4-methoxypyrimidin-5-yl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 190::US10512632, Example 190::US10766893, Example S190::US10806718, Example 190::US11026923, Example 190::US11491140, Example 190::US11634416, Example 190 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 74.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279159&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273480 378160736 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045261 CCOc1ncccc1CNc1cc(nc2c(C)nn(C(C)C)c12)-c1cccnc1OCC InChI=1S/C25H30N6O2/c1-6-32-24-18(10-8-12-26-24)15-28-21-14-20(19-11-9-13-27-25(19)33-7-2)29-22-17(5)30-31(16(3)4)23(21)22/h8-14,16H,6-7,15H2,1-5H3,(H,28,29) RPFGIRQWMRKNBU-UHFFFAOYSA-N 279160 5-(2-ethoxy-3-pyridyl)-N-[(2-ethoxy-3-pyridyl)methyl]-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 191::US10512632, Example 191::US10766893, Example S191::US10806718, Example 191::US11026923, Example 191::US11491140, Example 191::US11634416, Example 191 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 160 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279160&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273479 378160737 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045264 COc1ccc(CNc2cc(nc3c(C)nn(C(C)C)c23)-c2cccnc2N(C)C)cc1 InChI=1S/C25H30N6O/c1-16(2)31-24-22(27-15-18-9-11-19(32-6)12-10-18)14-21(28-23(24)17(3)29-31)20-8-7-13-26-25(20)30(4)5/h7-14,16H,15H2,1-6H3,(H,27,28) RMYFPLHNAGFJMC-UHFFFAOYSA-N 279161 5-[2-(dimethylamino)-3-pyridyl]-1-isopropyl-N-[(4-methoxyphenyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 192::US10512632, Example 192::US10766893, Example S192::US10806718, Example 192::US11026923, Example 192::US11491140, Example 192::US11634416, Example 192 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 630 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279161&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273481 378160738 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045267 CC(C)Nc1c(NCc2cccnc2C(F)(F)F)cc(nc1C(C)=N)-c1ccc[nH]c1=O InChI=1S/C22H23F3N6O/c1-12(2)30-19-17(29-11-14-6-4-8-27-20(14)22(23,24)25)10-16(31-18(19)13(3)26)15-7-5-9-28-21(15)32/h4-10,12,26,30H,11H2,1-3H3,(H,28,32)(H,29,31) QVDZHWJXZYVABG-UHFFFAOYSA-N 501564 3-[1-isopropyl-3-methyl-7-[[2-(trifluoromethyl)- 3-pyridyl]methylamino]pyrazolo[4,3-b]pyridin- 5-yl]-1H-pyridin-2-one::US11026923, Example 193 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 320 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501564&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 162370055 459086747 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045270 CC(C)Nc1c(NCc2cnn(C)c2)cc(nc1C(C)=N)C(=C\O)\C(C)=N InChI=1S/C19H27N7O/c1-11(2)24-19-17(22-7-14-8-23-26(5)9-14)6-16(15(10-27)12(3)20)25-18(19)13(4)21/h6,8-11,20-21,24,27H,7H2,1-5H3,(H,22,25)/b15-10+,20-12?,21-13? SRAOQVIQGWKOHT-JVUVJMHDSA-N 501565 1-isopropyl-3-methyl-5-(3-methylisoxazol-4- yl)-N-[(1-methylpyrazol-4- yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US11026923, Example 194 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 95.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501565 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501565&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 162370056 459086748 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045273 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1ncnn1C InChI=1S/C18H23N9/c1-11(2)27-17-14(19-7-13-8-21-25(4)9-13)6-15(18-20-10-22-26(18)5)23-16(17)12(3)24-27/h6,8-11H,7H2,1-5H3,(H,19,23) KYLSIDIKSXHHCI-UHFFFAOYSA-N 279164 1-isopropyl-3-methyl-5-(1-methyl-1H-1,2,4-triazol-5-yl)-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 195::US10512632, Example 195::US10618913, Example S195::US10766893, Example S195::US10806718, Example 195::US11026923, Example 195::US11634416, Example 195 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 420 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279164&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273486 378160741 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045276 CCCOc1ncccc1-c1cc(NCc2cn[nH]c2)c(NC(C)C)c(n1)C(C)=N InChI=1S/C22H29N7O/c1-5-9-30-22-17(7-6-8-24-22)18-10-19(25-11-16-12-26-27-13-16)21(28-14(2)3)20(29-18)15(4)23/h6-8,10,12-14,23,28H,5,9,11H2,1-4H3,(H,25,29)(H,26,27) QKGSYYLRVJDNCK-UHFFFAOYSA-N 501567 1-isopropyl-3-methyl-5-(2-propoxy-3-pyridyl)- N-(1H-pyrazol-4-ylmethyl)pyrazolo[4,3- b]pyridin-7-amine::US11026923, Example 196 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 18.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501567 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501567&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138746523 459086749 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045279 CCOc1ncccc1-c1cc(NCc2cccnc2OC)c(NC2COC2)c(n1)C(C)=N InChI=1S/C24H28N6O3/c1-4-33-24-18(8-6-10-27-24)19-11-20(28-12-16-7-5-9-26-23(16)31-3)22(21(30-19)15(2)25)29-17-13-32-14-17/h5-11,17,25,29H,4,12-14H2,1-3H3,(H,28,30) LWKMAOPQFDSIHC-UHFFFAOYSA-N 501568 5-(2-ethoxy-3-pyridyl)-N-[(2-methoxy-3- pyridyl)methyl]-3-methyl-1-(oxetan-3- yl)pyrazolo[4,3-b]pyridin-7-amine::US11026923, Example 197 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 190 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501568&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138746818 459086750 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045282 CCN(C)c1ncccc1-c1cc(NCc2ccc(OC)cc2)c2n(nc(C)c2n1)C(C)C InChI=1S/C26H32N6O/c1-7-31(5)26-21(9-8-14-27-26)22-15-23(28-16-19-10-12-20(33-6)13-11-19)25-24(29-22)18(4)30-32(25)17(2)3/h8-15,17H,7,16H2,1-6H3,(H,28,29) YNHQWVLFISTQIU-UHFFFAOYSA-N 279167 5-(2-(ethyl(methyl)amino)pyridin-3-yl)-1-isopropyl-N-(4-methoxybenzyl)-3-methyl-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 198::US10512632, Example 198::US10766893, Example S198::US10806718, Example 198::US11026923, Example 198::US11491140, Example 198::US11634416, Example 198 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1100 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279167 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279167&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273483 378160744 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045285 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(CF)c2n1)C(C)C InChI=1S/C22H26FN7O/c1-5-31-22-16(7-6-8-24-22)17-9-18(25-11-15-12-26-29(4)13-15)21-20(27-17)19(10-23)28-30(21)14(2)3/h6-9,12-14H,5,10-11H2,1-4H3,(H,25,27) CRFWOMGBISLKHY-UHFFFAOYSA-N 279168 5-(2-ethoxypyridin-3-yl)-3-(fluoromethyl)-1-isopropyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 199::US10512632, Example 199::US10618913, Example S199::US10766893, Example S199::US10806718, Example 199::US11026923, Example 199::US11491140, Example 199::US11634416, Example 199 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 7.40 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279168&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273487 378160745 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045288 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1ocnc1C InChI=1S/C19H23N7O/c1-11(2)26-18-15(20-7-14-8-22-25(5)9-14)6-16(19-13(4)21-10-27-19)23-17(18)12(3)24-26/h6,8-11H,7H2,1-5H3,(H,20,23) JVGYDVFOXCBHRN-UHFFFAOYSA-N 279169 1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-5-(4-methyloxazol-5-yl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 200::US10512632, Example 200::US10618913, Example S200::US10766893, Example S200::US10806718, Example 200::US11026923, Example 200::US11491140, Example 200::US11634416, Example 200 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 98.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279169&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273489 378160746 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045291 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1cccnc1N(C)C InChI=1S/C22H28N8/c1-14(2)30-21-19(24-11-16-12-25-29(6)13-16)10-18(26-20(21)15(3)27-30)17-8-7-9-23-22(17)28(4)5/h7-10,12-14H,11H2,1-6H3,(H,24,26) JWSSTJTVRAZILB-UHFFFAOYSA-N 279170 5-[2-(dimethylamino)-3-pyridyl]-1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 201::US10512632, Example 201::US10766893, Example S201::US10806718, Example 201::US11026923, Example 201::US11491140, Example 201::US11634416, Example 201 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2100 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279170&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273490 378160747 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045294 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1cc(C)co1 InChI=1S/C20H24N6O/c1-12(2)26-20-17(21-8-15-9-22-25(5)10-15)7-16(18-6-13(3)11-27-18)23-19(20)14(4)24-26/h6-7,9-12H,8H2,1-5H3,(H,21,23) OYRCQYGRHVDJSB-UHFFFAOYSA-N 501573 1-isopropyl-3-methyl-N-((1-methyl-1H- pyrazol-4-yl)methyl)-5-(4-methyloxazol-2-yl)- 1H-pyrazolo[4,3-b]pyridin-7-amine::US11026923, Example 202 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 92.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501573 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501573&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 155773327 459086751 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1045297 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1nncn1C InChI=1S/C18H23N9/c1-11(2)27-17-14(19-7-13-8-21-26(5)9-13)6-15(18-23-20-10-25(18)4)22-16(17)12(3)24-27/h6,8-11H,7H2,1-5H3,(H,19,22) KAIFDCSXZCWWKF-UHFFFAOYSA-N 279172 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-(4-methyl-1,2,4-triazol-3-::US10034861, Example 203::US10512632, Example 203::US10766893, Example S203::US10806718, Example 203::US11026923, Example 203::US11491140, Example 203::US11634416, Example 203 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 410 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279172 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279172&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273492 378160749 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044694 CCOc1ncccc1-c1cc(NCc2nnc(C)o2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H25N7O2/c1-6-29-21-15(8-7-9-22-21)16-10-17(23-11-18-26-25-14(5)30-18)20-19(24-16)13(4)27-28(20)12(2)3/h7-10,12H,6,11H2,1-5H3,(H,23,24) XEBJMVLHZBRKST-UHFFFAOYSA-N 278971 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methyl-1,3,4-oxadiazol-2-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 1::US10512632, Example 1::US10618913, Example S1::US10766893, Example S1::US10806718, Example 1::US11026923, Example 1::US11491140, Example 1::US11634416, Example 1 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 18.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278971 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278971&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273299 378160560 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044697 CCOc1ncccc1-c1cc(NCc2ncc(C)s2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6OS/c1-6-29-22-16(8-7-9-23-22)17-10-18(24-12-19-25-11-14(4)30-19)21-20(26-17)15(5)27-28(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,24,26) QOYNQFLWGDTXKT-UHFFFAOYSA-N 278972 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methylthiazol-2-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 2::US10512632, Example 2::US10766893, Example S2::US10806718, Example 2::US11026923, Example 2::US11491140, Example 2::US11634416, Example 2 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.460 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278972 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278972&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273301 378160561 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044700 CCOc1ncccc1-c1cc(NCc2cc(C)on2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6O2/c1-6-29-22-17(8-7-9-23-22)18-11-19(24-12-16-10-14(4)30-27-16)21-20(25-18)15(5)26-28(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,24,25) MKELJWFWEJOZNC-UHFFFAOYSA-N 278973 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methylisoxazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 3::US10512632, Example 3::US10766893, Example S3::US10806718, Example 3::US11026923, Example 3::US11491140, Example 3::US11634416, Example 3 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.800 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278973&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273302 378160562 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044703 CCOc1ncccc1-c1cc(NCc2cnc(C)o2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6O2/c1-6-29-22-17(8-7-9-23-22)18-10-19(25-12-16-11-24-15(5)30-16)21-20(26-18)14(4)27-28(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,25,26) TWDRBTLHNZMOLP-UHFFFAOYSA-N 278974 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methyloxazol-5-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 4::US10512632, Example 4::US10766893, Example S4::US10806718, Example 4::US11026923, Example 4::US11491140, Example 4::US11634416, Example 4 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.60 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278974 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278974&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273304 378160563 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044706 CCOc1ncccc1-c1cc(NCc2cnn(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-6-30-21-16(8-7-9-22-21)17-10-18(23-11-15-12-24-28(5)27-15)20-19(25-17)14(4)26-29(20)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,23,25) RKVBYUMNPKGITG-UHFFFAOYSA-N 278975 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methyltriazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 5::US10512632, Example 5::US10766893, Example S5::US10806718, Example 5::US11026923, Example 5::US11491140, Example 5::US11634416, Example 5 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 11.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278975&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273303 378160564 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044709 CCOc1ncccc1-c1cc(NCc2cn(C)nn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-6-30-21-16(8-7-9-22-21)17-10-18(23-11-15-12-28(5)27-25-15)20-19(24-17)14(4)26-29(20)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,23,24) GZZVSCZGHCUFQG-UHFFFAOYSA-N 278976 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(1-methyltriazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 6::US10512632, Example 6::US10766893, Example S6::US10806718, Example 6::US11026923, Example 6::US11491140, Example 6::US11634416, Example 6 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4.80 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278976&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273306 378160565 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044712 CCOc1ncccc1-c1cc(NCc2cn[nH]c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H25N7O/c1-5-29-21-16(7-6-8-22-21)17-9-18(23-10-15-11-24-25-12-15)20-19(26-17)14(4)27-28(20)13(2)3/h6-9,11-13H,5,10H2,1-4H3,(H,23,26)(H,24,25) ZBYZXMQLZZULRF-UHFFFAOYSA-N 278977 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1H-pyrazol-4-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 7::US10512632, Example 7::US10766893, Example S7::US10806718, Example 7::US11026923, Example 7::US11491140, Example 7::US11634416, Example 7 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 21.0 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278977 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278977&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 136214891 378160566 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044715 CCOc1ncccc1-c1cc(NCc2nnn(C)n2)c(NC(C)C)c(n1)C(C)=N InChI=1S/C20H27N9O/c1-6-30-20-14(8-7-9-22-20)15-10-16(23-11-17-26-28-29(5)27-17)19(24-12(2)3)18(25-15)13(4)21/h7-10,12,21,24H,6,11H2,1-5H3,(H,23,25) HRQDHIDSKXKALG-UHFFFAOYSA-N 501373 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N- [(2-methyltetrazol-5-yl)methyl]pyrazolo[4,3- b]pyridin-7-amine::US11026923, Example 8 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.90 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501373 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501373&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 155773339 459086713 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044718 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c(NC(C)C)c(n1)C(C)=N InChI=1S/C22H29N7O/c1-6-30-22-17(8-7-9-24-22)18-10-19(25-11-16-12-26-29(5)13-16)21(27-14(2)3)20(28-18)15(4)23/h7-10,12-14,23,27H,6,11H2,1-5H3,(H,25,28) DYQWQIHQGJJUCO-UHFFFAOYSA-N 501374 5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl- N-((1-methyl-1H-pyrazol-4-yl)methyl)-1H- pyrazolo[4,3-b]pyridin-7-amine::US11026923, Example 9 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.60 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501374 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501374&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 155773324 459086714 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044721 CCOc1ncccc1-c1cc(NCc2cc(C)no2)c(NC(C)C)c(n1)C(C)=N InChI=1S/C22H28N6O2/c1-6-29-22-17(8-7-9-24-22)18-11-19(25-12-16-10-14(4)28-30-16)21(26-13(2)3)20(27-18)15(5)23/h7-11,13,23,26H,6,12H2,1-5H3,(H,25,27) OIHDLGXDSFYCRF-UHFFFAOYSA-N 501375 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N- [(3-methylisoxazol-5-yl)methyl]pyrazolo[4,3- b]pyridin-7-amine::US11026923, Example 10 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4.10 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501375 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501375&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138746915 459086715 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1044724 CCOc1ncccc1-c1cc(NCc2csc(C)n2)c(NC(C)C)c(n1)C(C)=N InChI=1S/C22H28N6OS/c1-6-29-22-17(8-7-9-24-22)18-10-19(25-11-16-12-30-15(5)27-16)21(26-13(2)3)20(28-18)14(4)23/h7-10,12-13,23,26H,6,11H2,1-5H3,(H,25,28) FWBNMGXZQLQVCM-UHFFFAOYSA-N 501377 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N- [(2-methylthiazol-4-yl)methyl]pyrazolo[4,3- b]pyridin-7-amine::US11026923, Example 11 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 9.60 US Patent 10.7270/Q20R9SJ9 aid1805617 US11026923 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501377 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501377&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 142604710 459086716 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1116654 CCCCn1c2cc(C)cnc2n2c(nnc2c1=O)C1(CC1)C1CC1 InChI=1S/C19H23N5O/c1-3-4-9-23-14-10-12(2)11-20-15(14)24-16(17(23)25)21-22-18(24)19(7-8-19)13-5-6-13/h10-11,13H,3-9H2,1-2H3 HINKCAKLUHRIQD-UHFFFAOYSA-N 528331 9-([1,1'-bi(cyclopropan)]-1-yl)-5-butyl-3-methylpyrido[3,2-e][1,2,4]triazolo[4,3-a]pyrazin-6(5H)-one::US11180503, Example 1 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.366 US Patent 10.7270/Q27947WZ aid1806160 US11180503 Genin, MJ; Holloway, WG; Johnston, RD; Morphy, JR; Shi, Q ELI LILLY AND COMPANY http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=528331 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=528331&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 163200085 463791869 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1116657 CCCCn1c2cc(C)cnc2n2c(nnc2c1=O)C1(CC1)C(F)(F)F InChI=1S/C17H18F3N5O/c1-3-4-7-24-11-8-10(2)9-21-12(11)25-13(14(24)26)22-23-15(25)16(5-6-16)17(18,19)20/h8-9H,3-7H2,1-2H3 IGWJBYVNICAEOE-UHFFFAOYSA-N 528332 5-Butyl-3- methyl-9-(1- (trifluoromethyl) cyclopropyl)pyrido [3,2-e][1,2,4] triazolo[4,3- a]pyrazin- 6(5H)-one::US11180503, Example 2 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.62 US Patent 10.7270/Q27947WZ aid1806160 US11180503 Genin, MJ; Holloway, WG; Johnston, RD; Morphy, JR; Shi, Q ELI LILLY AND COMPANY http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=528332 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=528332&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 163200086 463791870 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1116660 CCCn1c2cc(C)cnc2n2c(nnc2c1=O)C1(CC1)C1CC1 InChI=1S/C18H21N5O/c1-3-8-22-13-9-11(2)10-19-14(13)23-15(16(22)24)20-21-17(23)18(6-7-18)12-4-5-12/h9-10,12H,3-8H2,1-2H3 QGLGRZAUXUEFDA-UHFFFAOYSA-N 528333 9-([1,1'- Bi(cyclopropan)]- 1-yl)-3- methyl-5- propylpyrido[3,2- e][1,2,4]triazolo[4,3- a]pyrazin-6(5H)-one::US11180503, Example 3 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.59 US Patent 10.7270/Q27947WZ aid1806160 US11180503 Genin, MJ; Holloway, WG; Johnston, RD; Morphy, JR; Shi, Q ELI LILLY AND COMPANY http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=528333 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=528333&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 163200087 463791871 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1116663 CCC(Cn1c2cccnc2n2c(nnc2c1=O)C1(CC1)C1CC1)OC InChI=1S/C19H23N5O2/c1-3-13(26-2)11-23-14-5-4-10-20-15(14)24-16(17(23)25)21-22-18(24)19(8-9-19)12-6-7-12/h4-5,10,12-13H,3,6-9,11H2,1-2H3 PYLSAACWAQSKHB-UHFFFAOYSA-N 528334 US11180503, Example 4::US11180503, Example 4a::US11180503, Example 4b::rac-9-([1,1''- Bi(cyclopropan)]-1- yl)-5-(2- methoxybutyl)- pyrido[3,2- e][1,2,4]triazolo [4,3-a]pyrazin- 6(5H)-one Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 13.9 US Patent 10.7270/Q27947WZ aid1806160 US11180503 Genin, MJ; Holloway, WG; Johnston, RD; Morphy, JR; Shi, Q ELI LILLY AND COMPANY http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=528334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=528334&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 163200088 463791872 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1116666 CCC(Cn1c2cccnc2n2c(nnc2c1=O)C1(CC1)C1CC1)OC InChI=1S/C19H23N5O2/c1-3-13(26-2)11-23-14-5-4-10-20-15(14)24-16(17(23)25)21-22-18(24)19(8-9-19)12-6-7-12/h4-5,10,12-13H,3,6-9,11H2,1-2H3 PYLSAACWAQSKHB-UHFFFAOYSA-N 528334 US11180503, Example 4::US11180503, Example 4a::US11180503, Example 4b::rac-9-([1,1''- Bi(cyclopropan)]-1- yl)-5-(2- methoxybutyl)- pyrido[3,2- e][1,2,4]triazolo [4,3-a]pyrazin- 6(5H)-one Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 26.8 US Patent 10.7270/Q27947WZ aid1806160 US11180503 Genin, MJ; Holloway, WG; Johnston, RD; Morphy, JR; Shi, Q ELI LILLY AND COMPANY http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=528334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=528334&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 163200088 463791872 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1116669 CCC(Cn1c2cccnc2n2c(nnc2c1=O)C1(CC1)C1CC1)OC InChI=1S/C19H23N5O2/c1-3-13(26-2)11-23-14-5-4-10-20-15(14)24-16(17(23)25)21-22-18(24)19(8-9-19)12-6-7-12/h4-5,10,12-13H,3,6-9,11H2,1-2H3 PYLSAACWAQSKHB-UHFFFAOYSA-N 528334 US11180503, Example 4::US11180503, Example 4a::US11180503, Example 4b::rac-9-([1,1''- Bi(cyclopropan)]-1- yl)-5-(2- methoxybutyl)- pyrido[3,2- e][1,2,4]triazolo [4,3-a]pyrazin- 6(5H)-one Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 15.1 US Patent 10.7270/Q27947WZ aid1806160 US11180503 Genin, MJ; Holloway, WG; Johnston, RD; Morphy, JR; Shi, Q ELI LILLY AND COMPANY http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=528334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=528334&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 163200088 463791872 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1116672 Oc1ccc2n(CC3CC3)c(=O)c3nnc(n3c2n1)C1(CC1)C1CC1 InChI=1S/C18H19N5O2/c24-13-6-5-12-14(19-13)23-15(16(25)22(12)9-10-1-2-10)20-21-17(23)18(7-8-18)11-3-4-11/h5-6,10-11H,1-4,7-9H2,(H,19,24) XNUXIYGMZDJLFB-UHFFFAOYSA-N 528347 9-([1,1'-bi(cylopropan)]-1-yl)-5-(cyclopropylmethyl)-2-hydroxypyrido[3,2-e][1,2,4]triazolo[4,3-a]pyrazin-6(5H)-one::US11180503, Example 5 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.75 US Patent 10.7270/Q27947WZ aid1806160 US11180503 Genin, MJ; Holloway, WG; Johnston, RD; Morphy, JR; Shi, Q ELI LILLY AND COMPANY http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=528347 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=528347&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 163200089 463791883 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1116675 CCCCn1c2cc(C)cnc2n2c(nnc2c1=O)C1(C)CC1 InChI=1S/C17H21N5O/c1-4-5-8-21-12-9-11(2)10-18-13(12)22-14(15(21)23)19-20-16(22)17(3)6-7-17/h9-10H,4-8H2,1-3H3 OBFZSUOIZKEKHN-UHFFFAOYSA-N 528348 5-butyl-3-methyl-9-(1-methylcyclopropyl)pyrido[3,2-e][1,2,4]triazolo[4,3-a]pyrazin-6(5H)-one::US11180503, Example 6 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 11.6 US Patent 10.7270/Q27947WZ aid1806160 US11180503 Genin, MJ; Holloway, WG; Johnston, RD; Morphy, JR; Shi, Q ELI LILLY AND COMPANY http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=528348 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=528348&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 163200090 463791884 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1116678 CCCCn1c2cc(C)c(C)nc2n2c(nnc2c1=O)C1(CC1)C1CC1 InChI=1S/C20H25N5O/c1-4-5-10-24-15-11-12(2)13(3)21-16(15)25-17(18(24)26)22-23-19(25)20(8-9-20)14-6-7-14/h11,14H,4-10H2,1-3H3 GHJOVBRBPVEUOD-UHFFFAOYSA-N 528349 9-([1,1'- Bi(cyclopropan)]-1- yl)-5-butyl-2,3- dimethylpyrido[3,2- e][1,2,4]triazolo[4,3- a]pyrazin-6(5H)-one::US11180503, Example 7 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.343 US Patent 10.7270/Q27947WZ aid1806160 US11180503 Genin, MJ; Holloway, WG; Johnston, RD; Morphy, JR; Shi, Q ELI LILLY AND COMPANY http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=528349 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=528349&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 163200091 463791885 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1116681 CCCCn1c2cc(CC)cnc2n2c(nnc2c1=O)C1(C)CC1 InChI=1S/C18H23N5O/c1-4-6-9-22-13-10-12(5-2)11-19-14(13)23-15(16(22)24)20-21-17(23)18(3)7-8-18/h10-11H,4-9H2,1-3H3 RYEATKXYIIMQSN-UHFFFAOYSA-N 528350 5-butyl-3-ethyl-9-(1-methylcyclopropyl)pyrido[3,2-e][1,2,4]triazolo[4,3-a]pyrazin-6(5H)-one::US11180503, Example 8 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.01 US Patent 10.7270/Q27947WZ aid1806160 US11180503 Genin, MJ; Holloway, WG; Johnston, RD; Morphy, JR; Shi, Q ELI LILLY AND COMPANY http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=528350 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=528350&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 163200092 463791886 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1116684 CCCCn1c2cc(CC)cnc2n2c(nnc2c1=O)C1(CC1)C1CC1 InChI=1S/C20H25N5O/c1-3-5-10-24-15-11-13(4-2)12-21-16(15)25-17(18(24)26)22-23-19(25)20(8-9-20)14-6-7-14/h11-12,14H,3-10H2,1-2H3 YAZFJAWMJDOHDF-UHFFFAOYSA-N 528351 9-([1,1'- Bi(cyclopropan)]-1- yl)-5-butyl-3- ethylpyrido[3,2- e][1,2,4]triazolo[4,3- a]pyrazin-6(5H)-one::US11180503, Example 9 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.214 US Patent 10.7270/Q27947WZ aid1806160 US11180503 Genin, MJ; Holloway, WG; Johnston, RD; Morphy, JR; Shi, Q ELI LILLY AND COMPANY http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=528351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=528351&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 163200093 463791887 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1116687 CCCCn1c2cc(cnc2n2c(nnc2c1=O)C1(CC1)C1CC1)C(C)C InChI=1S/C21H27N5O/c1-4-5-10-25-16-11-14(13(2)3)12-22-17(16)26-18(19(25)27)23-24-20(26)21(8-9-21)15-6-7-15/h11-13,15H,4-10H2,1-3H3 KSTNYSJSCGBUFA-UHFFFAOYSA-N 528352 9-([1,1'-bi(cyclopropan)]-1-yl)-5-butyl-3-isopropylpyrido[3,2-e][1,2,4]triazolo[4,3-a]pyrazin-6(5H)-one::US11180503, Example 10 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.260 US Patent 10.7270/Q27947WZ aid1806160 US11180503 Genin, MJ; Holloway, WG; Johnston, RD; Morphy, JR; Shi, Q ELI LILLY AND COMPANY http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=528352 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=528352&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 163200094 463791888 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1116690 CCCCn1c2cc(CO)cnc2n2c(nnc2c1=O)C1(CC1)C1CC1 InChI=1S/C19H23N5O2/c1-2-3-8-23-14-9-12(11-25)10-20-15(14)24-16(17(23)26)21-22-18(24)19(6-7-19)13-4-5-13/h9-10,13,25H,2-8,11H2,1H3 FLZRLEPPHKZGPK-UHFFFAOYSA-N 528353 9-([1,1'-bi(cyclopropan)]-1-yl)-5-butyl-3-((2-(trimethylsilyl)ethoxy)methyl)pyrido[3,2-e][1,2,4]triazolo[4,3-a]pyrazin-6(5H)-one::US11180503, Example 11 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.996 US Patent 10.7270/Q27947WZ aid1806160 US11180503 Genin, MJ; Holloway, WG; Johnston, RD; Morphy, JR; Shi, Q ELI LILLY AND COMPANY http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=528353 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=528353&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 163200095 463791889 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1116693 CCCCn1c2cc(CO)cnc2n2c(nnc2c1=O)C1(C)CC1 InChI=1S/C17H21N5O2/c1-3-4-7-21-12-8-11(10-23)9-18-13(12)22-14(15(21)24)19-20-16(22)17(2)5-6-17/h8-9,23H,3-7,10H2,1-2H3 SHRITIDUUZZEIX-UHFFFAOYSA-N 528354 5-Butyl-3- (hydroxymethyl)-9- (1- methylcyclopropyl) pyrido[3,2- e][1,2,4]triazolo[4,3- a]pyrazin-6(5H)-one::US11180503, Example 12 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 23.0 US Patent 10.7270/Q27947WZ aid1806160 US11180503 Genin, MJ; Holloway, WG; Johnston, RD; Morphy, JR; Shi, Q ELI LILLY AND COMPANY http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=528354 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=528354&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 163200096 463791890 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1116696 CCCCn1c2ccc(C)nc2n2c(nnc2c1=O)C1(CC1)C1CC1 InChI=1S/C19H23N5O/c1-3-4-11-23-14-8-5-12(2)20-15(14)24-16(17(23)25)21-22-18(24)19(9-10-19)13-6-7-13/h5,8,13H,3-4,6-7,9-11H2,1-2H3 OZQQLPFSQLZXQT-UHFFFAOYSA-N 528355 9-([1,1'-bi(cyclopropan)]-1-yl)-5-butyl-2-methylpyrido[3,2-e][1,2,4]triazolo[4,3-a]pyrazin-6(5H)-one::US11180503, Example 13 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.816 US Patent 10.7270/Q27947WZ aid1806160 US11180503 Genin, MJ; Holloway, WG; Johnston, RD; Morphy, JR; Shi, Q ELI LILLY AND COMPANY http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=528355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=528355&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 163200097 463791891 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51407427 OB1OCc2cc(Oc3ccc(cc3)C#N)ccc12 InChI=1S/C14H10BNO3/c16-8-10-1-3-12(4-2-10)19-13-5-6-14-11(7-13)9-18-15(14)17/h1-7,17H,9H2 USZAGAREISWJDP-UHFFFAOYSA-N 50277665 4-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yloxy)benzonitrile::5-(4-cyanophenoxy)-2,3-dihydro-1-hydroxy-2,1-benzoxaborole::AN-2728::CHEMBL484785::Crisaborole::Eucrisa Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 5600000 ChEMBL 10.1016/j.ejmech.2021.113171 10.7270/Q2KW5KTJ 33482600 Chu, Z; Xu, Q; Zhu, Q; Ma, X; Mo, J; Lin, G; Zhao, Y; Gu, Y; Bian, L; Shao, L; Guo, J; Ye, W; Li, J; He, G; Xu, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50277665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50277665&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 44591583 104120185 CHEMBL484785 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51407428 OB1OCc2cc(Oc3ccc4cc(ccc4n3)C(F)(F)F)ccc12 InChI=1S/C17H11BF3NO3/c19-17(20,21)12-2-5-15-10(7-12)1-6-16(22-15)25-13-3-4-14-11(8-13)9-24-18(14)23/h1-8,23H,9H2 KGZSJRMZCOFGIJ-UHFFFAOYSA-N 50568657 CHEMBL4872870 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 64700 ChEMBL 10.1016/j.ejmech.2021.113171 10.7270/Q2KW5KTJ 33482600 Chu, Z; Xu, Q; Zhu, Q; Ma, X; Mo, J; Lin, G; Zhao, Y; Gu, Y; Bian, L; Shao, L; Guo, J; Ye, W; Li, J; He, G; Xu, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568657 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568657&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 164624366 471058802 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51402124 COc1ccc(cc1)C1CC(=NN1c1ccc(cc1)C(=O)NCCO)c1ccccc1C InChI=1S/C26H27N3O3/c1-18-5-3-4-6-23(18)24-17-25(19-9-13-22(32-2)14-10-19)29(28-24)21-11-7-20(8-12-21)26(31)27-15-16-30/h3-14,25,30H,15-17H2,1-2H3,(H,27,31) IAANKOGQBDQYIA-UHFFFAOYSA-N 50566432 CHEMBL4861917 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >10000 ChEMBL 10.1021/acs.jmedchem.0c01120 10.7270/Q2765K34 33793216 Abdel-Halim, M; Sigler, S; Racheed, NAS; Hefnawy, A; Fathalla, RK; Hammam, MA; Maher, A; Maxuitenko, Y; Keeton, AB; Hartmann, RW; Engel, M; Piazza, GA; Abadi, AH German University in Cairo http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50566432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50566432&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 164619506 471056577 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51402125 COc1c(F)cc(cc1F)C1CC(=NN1c1ccc(cc1)C(=O)N1CCN(C)CC1)C(C)(C)C InChI=1S/C26H32F2N4O2/c1-26(2,3)23-16-22(18-14-20(27)24(34-5)21(28)15-18)32(29-23)19-8-6-17(7-9-19)25(33)31-12-10-30(4)11-13-31/h6-9,14-15,22H,10-13,16H2,1-5H3 UTEKZOROJZXCET-UHFFFAOYSA-N 50566435 CHEMBL4872902 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >10000 ChEMBL 10.1021/acs.jmedchem.0c01120 10.7270/Q2765K34 33793216 Abdel-Halim, M; Sigler, S; Racheed, NAS; Hefnawy, A; Fathalla, RK; Hammam, MA; Maher, A; Maxuitenko, Y; Keeton, AB; Hartmann, RW; Engel, M; Piazza, GA; Abadi, AH German University in Cairo http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50566435 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50566435&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 164622052 471056580 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51402126 COc1ccc(cc1)C1CC(=NN1c1ccc(cc1)C(=O)N1CCN(C)CC1)c1ccccc1C InChI=1S/C29H32N4O2/c1-21-6-4-5-7-26(21)27-20-28(22-10-14-25(35-3)15-11-22)33(30-27)24-12-8-23(9-13-24)29(34)32-18-16-31(2)17-19-32/h4-15,28H,16-20H2,1-3H3 JEPQMOXLJIDDMY-UHFFFAOYSA-N 50566438 CHEMBL4852714 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >10000 ChEMBL 10.1021/acs.jmedchem.0c01120 10.7270/Q2765K34 33793216 Abdel-Halim, M; Sigler, S; Racheed, NAS; Hefnawy, A; Fathalla, RK; Hammam, MA; Maher, A; Maxuitenko, Y; Keeton, AB; Hartmann, RW; Engel, M; Piazza, GA; Abadi, AH German University in Cairo http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50566438 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50566438&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 164611751 471056583 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51402127 COc1ccc(cc1F)C1CC(=NN1c1ccc(cc1)C(=O)N1CCN(C)CC1)c1ccccc1C InChI=1S/C29H31FN4O2/c1-20-6-4-5-7-24(20)26-19-27(22-10-13-28(36-3)25(30)18-22)34(31-26)23-11-8-21(9-12-23)29(35)33-16-14-32(2)15-17-33/h4-13,18,27H,14-17,19H2,1-3H3 YKESFJBBYRLROW-UHFFFAOYSA-N 50566439 CHEMBL4869439 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >10000 ChEMBL 10.1021/acs.jmedchem.0c01120 10.7270/Q2765K34 33793216 Abdel-Halim, M; Sigler, S; Racheed, NAS; Hefnawy, A; Fathalla, RK; Hammam, MA; Maher, A; Maxuitenko, Y; Keeton, AB; Hartmann, RW; Engel, M; Piazza, GA; Abadi, AH German University in Cairo http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50566439 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50566439&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 164618519 471056584 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51402128 COc1ccc(C2CC(=NN2c2ccc(cc2)C(=O)N2CCN(C)CC2)C(C)(C)C)c(F)c1F InChI=1S/C26H32F2N4O2/c1-26(2,3)22-16-20(19-10-11-21(34-5)24(28)23(19)27)32(29-22)18-8-6-17(7-9-18)25(33)31-14-12-30(4)13-15-31/h6-11,20H,12-16H2,1-5H3 INLXRJLYIMPNFU-UHFFFAOYSA-N 50566443 CHEMBL4879176 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >10000 ChEMBL 10.1021/acs.jmedchem.0c01120 10.7270/Q2765K34 33793216 Abdel-Halim, M; Sigler, S; Racheed, NAS; Hefnawy, A; Fathalla, RK; Hammam, MA; Maher, A; Maxuitenko, Y; Keeton, AB; Hartmann, RW; Engel, M; Piazza, GA; Abadi, AH German University in Cairo http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50566443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50566443&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 164628091 471056588 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51402129 COc1ccc(cc1)C1CC(=NN1c1ccc(cc1)C(=O)NCCO)c1ccccc1C InChI=1S/C26H27N3O3/c1-18-5-3-4-6-23(18)24-17-25(19-9-13-22(32-2)14-10-19)29(28-24)21-11-7-20(8-12-21)26(31)27-15-16-30/h3-14,25,30H,15-17H2,1-2H3,(H,27,31) IAANKOGQBDQYIA-UHFFFAOYSA-N 50566432 CHEMBL4861917 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >10000 ChEMBL 10.1021/acs.jmedchem.0c01120 10.7270/Q2765K34 33793216 Abdel-Halim, M; Sigler, S; Racheed, NAS; Hefnawy, A; Fathalla, RK; Hammam, MA; Maher, A; Maxuitenko, Y; Keeton, AB; Hartmann, RW; Engel, M; Piazza, GA; Abadi, AH German University in Cairo http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50566432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50566432&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 164619506 471056577 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51402130 COc1c(F)cc(cc1F)C1CC(=NN1c1ccc(cc1)C(=O)N1CCN(C)CC1)C(C)(C)C InChI=1S/C26H32F2N4O2/c1-26(2,3)23-16-22(18-14-20(27)24(34-5)21(28)15-18)32(29-23)19-8-6-17(7-9-19)25(33)31-12-10-30(4)11-13-31/h6-9,14-15,22H,10-13,16H2,1-5H3 UTEKZOROJZXCET-UHFFFAOYSA-N 50566435 CHEMBL4872902 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >10000 ChEMBL 10.1021/acs.jmedchem.0c01120 10.7270/Q2765K34 33793216 Abdel-Halim, M; Sigler, S; Racheed, NAS; Hefnawy, A; Fathalla, RK; Hammam, MA; Maher, A; Maxuitenko, Y; Keeton, AB; Hartmann, RW; Engel, M; Piazza, GA; Abadi, AH German University in Cairo http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50566435 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50566435&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 164622052 471056580 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51402131 COc1ccc(cc1)C1CC(=NN1c1ccc(cc1)C(=O)N1CCN(C)CC1)c1ccccc1C InChI=1S/C29H32N4O2/c1-21-6-4-5-7-26(21)27-20-28(22-10-14-25(35-3)15-11-22)33(30-27)24-12-8-23(9-13-24)29(34)32-18-16-31(2)17-19-32/h4-15,28H,16-20H2,1-3H3 JEPQMOXLJIDDMY-UHFFFAOYSA-N 50566438 CHEMBL4852714 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >10000 ChEMBL 10.1021/acs.jmedchem.0c01120 10.7270/Q2765K34 33793216 Abdel-Halim, M; Sigler, S; Racheed, NAS; Hefnawy, A; Fathalla, RK; Hammam, MA; Maher, A; Maxuitenko, Y; Keeton, AB; Hartmann, RW; Engel, M; Piazza, GA; Abadi, AH German University in Cairo http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50566438 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50566438&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 164611751 471056583 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51402132 COc1ccc(cc1F)C1CC(=NN1c1ccc(cc1)C(=O)N1CCN(C)CC1)c1ccccc1C InChI=1S/C29H31FN4O2/c1-20-6-4-5-7-24(20)26-19-27(22-10-13-28(36-3)25(30)18-22)34(31-26)23-11-8-21(9-12-23)29(35)33-16-14-32(2)15-17-33/h4-13,18,27H,14-17,19H2,1-3H3 YKESFJBBYRLROW-UHFFFAOYSA-N 50566439 CHEMBL4869439 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >10000 ChEMBL 10.1021/acs.jmedchem.0c01120 10.7270/Q2765K34 33793216 Abdel-Halim, M; Sigler, S; Racheed, NAS; Hefnawy, A; Fathalla, RK; Hammam, MA; Maher, A; Maxuitenko, Y; Keeton, AB; Hartmann, RW; Engel, M; Piazza, GA; Abadi, AH German University in Cairo http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50566439 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50566439&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 164618519 471056584 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51402133 COc1ccc(C2CC(=NN2c2ccc(cc2)C(=O)N2CCN(C)CC2)C(C)(C)C)c(F)c1F InChI=1S/C26H32F2N4O2/c1-26(2,3)22-16-20(19-10-11-21(34-5)24(28)23(19)27)32(29-22)18-8-6-17(7-9-18)25(33)31-14-12-30(4)13-15-31/h6-11,20H,12-16H2,1-5H3 INLXRJLYIMPNFU-UHFFFAOYSA-N 50566443 CHEMBL4879176 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >10000 ChEMBL 10.1021/acs.jmedchem.0c01120 10.7270/Q2765K34 33793216 Abdel-Halim, M; Sigler, S; Racheed, NAS; Hefnawy, A; Fathalla, RK; Hammam, MA; Maher, A; Maxuitenko, Y; Keeton, AB; Hartmann, RW; Engel, M; Piazza, GA; Abadi, AH German University in Cairo http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50566443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50566443&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 164628091 471056588 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51410851 COc1cc2CCN(C=O)[C@@H](Cc3c[nH]c4c(Cl)cccc34)c2cc1OC 50569910 CHEMBL4848137 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >5000 ChEMBL 10.1016/j.ejmech.2020.113004 10.7270/Q20P13TW 33218684 Zhang, R; Li, H; Zhang, X; Li, J; Su, H; Lu, Q; Dong, G; Dou, H; Fan, C; Gu, Z; Mu, Q; Tang, W; Xu, Y; Liu, H Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50569910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50569910&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search FTX 155923496 471060055 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1209444 Cn1cc(Cc2cn3c(nnc3c(=O)n2CC2CC2)C2(CC2)C2CC2)cn1 InChI=1S/C20H24N6O/c1-24-10-14(9-21-24)8-16-12-26-17(18(27)25(16)11-13-2-3-13)22-23-19(26)20(6-7-20)15-4-5-15/h9-10,12-13,15H,2-8,11H2,1H3 QWUMEFVSWZCRDK-UHFFFAOYSA-N 573134 US11453673, Example 1 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 20.3 US Patent 10.7270/Q22Z18RF aid1806837 US11453673 Camp, NP; Hamdouchi, C; Lineswala, JP; Morphy, JR; Shi, Q ELI LILLY AND COMPANY http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=573134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=573134&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 166177396 474495514 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1209447 Cc1c(C)n2c(nnc2c(=O)n1CC1CC1)C1(CC1)C1CC1 InChI=1S/C17H22N4O/c1-10-11(2)21-14(15(22)20(10)9-12-3-4-12)18-19-16(21)17(7-8-17)13-5-6-13/h12-13H,3-9H2,1-2H3 YCKJCPNPYHTASY-UHFFFAOYSA-N 573135 US11453673, Example 2 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 3.73 US Patent 10.7270/Q22Z18RF aid1806837 US11453673 Camp, NP; Hamdouchi, C; Lineswala, JP; Morphy, JR; Shi, Q ELI LILLY AND COMPANY http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=573135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=573135&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 166177397 474495515 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1209450 CCCCCn1c(C)c(C)n2c(nnc2c1=O)C1(CC1)C1CC1 InChI=1S/C18H26N4O/c1-4-5-6-11-21-12(2)13(3)22-15(16(21)23)19-20-17(22)18(9-10-18)14-7-8-14/h14H,4-11H2,1-3H3 ZPJIMTDAUYYCBN-UHFFFAOYSA-N 573136 US11453673, Example 3 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 11.0 US Patent 10.7270/Q22Z18RF aid1806837 US11453673 Camp, NP; Hamdouchi, C; Lineswala, JP; Morphy, JR; Shi, Q ELI LILLY AND COMPANY http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=573136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=573136&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 166177398 474495516 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1209453 Cc1c(C)n2c(nnc2c(=O)n1CC1CCC1)C1(CC1)C1CC1 InChI=1S/C18H24N4O/c1-11-12(2)22-15(16(23)21(11)10-13-4-3-5-13)19-20-17(22)18(8-9-18)14-6-7-14/h13-14H,3-10H2,1-2H3 ZLTYIDKHKFGNFO-UHFFFAOYSA-N 573138 US11453673, Example 4 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 3.71 US Patent 10.7270/Q22Z18RF aid1806837 US11453673 Camp, NP; Hamdouchi, C; Lineswala, JP; Morphy, JR; Shi, Q ELI LILLY AND COMPANY http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=573138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=573138&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 166177400 474495518 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1209456 CCCCn1c(C)c(C)n2c(nnc2c1=O)C1(CC1)C1CC1 InChI=1S/C17H24N4O/c1-4-5-10-20-11(2)12(3)21-14(15(20)22)18-19-16(21)17(8-9-17)13-6-7-13/h13H,4-10H2,1-3H3 IFZLBONFERYGEE-UHFFFAOYSA-N 573139 US11453673, Example 5 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 11.5 US Patent 10.7270/Q22Z18RF aid1806837 US11453673 Camp, NP; Hamdouchi, C; Lineswala, JP; Morphy, JR; Shi, Q ELI LILLY AND COMPANY http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=573139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=573139&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 166177401 474495519 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1209459 Cc1c(C)n2c(nnc2c(=O)n1CC1CCCCO1)C1(CC1)C1CC1 InChI=1S/C19H26N4O2/c1-12-13(2)23-16(17(24)22(12)11-15-5-3-4-10-25-15)20-21-18(23)19(8-9-19)14-6-7-14/h14-15H,3-11H2,1-2H3 NLIMXPGAJBMBAG-UHFFFAOYSA-N 573144 US11453673, Example 6 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 5.98 US Patent 10.7270/Q22Z18RF aid1806837 US11453673 Camp, NP; Hamdouchi, C; Lineswala, JP; Morphy, JR; Shi, Q ELI LILLY AND COMPANY http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=573144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=573144&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 166177406 474495524 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1209462 CCC1(CC1)c1nnc2n1c(C)c(C)n(CC1CCCCO1)c2=O InChI=1S/C18H26N4O2/c1-4-18(8-9-18)17-20-19-15-16(23)21(12(2)13(3)22(15)17)11-14-7-5-6-10-24-14/h14H,4-11H2,1-3H3 UFODZZUTBCVMAU-UHFFFAOYSA-N 573145 US11453673, Example 7 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 32.7 US Patent 10.7270/Q22Z18RF aid1806837 US11453673 Camp, NP; Hamdouchi, C; Lineswala, JP; Morphy, JR; Shi, Q ELI LILLY AND COMPANY http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=573145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=573145&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 166177407 474495525 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1209465 Cc1c(C)n2c(nnc2c(=O)n1CC1CCCCO1)C1(C)CC1 InChI=1S/C17H24N4O2/c1-11-12(2)21-14(18-19-16(21)17(3)7-8-17)15(22)20(11)10-13-6-4-5-9-23-13/h13H,4-10H2,1-3H3 HAKBILSEBDWPBF-UHFFFAOYSA-N 573146 US11453673, Example 8 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 25.4 US Patent 10.7270/Q22Z18RF aid1806837 US11453673 Camp, NP; Hamdouchi, C; Lineswala, JP; Morphy, JR; Shi, Q ELI LILLY AND COMPANY http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=573146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=573146&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 166177408 474495526 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1209468 Cc1c(C)n2c(nnc2c(=O)n1C[C@H]1CCCCO1)C1(CC1)C1CC1 InChI=1S/C19H26N4O2/c1-12-13(2)23-16(17(24)22(12)11-15-5-3-4-10-25-15)20-21-18(23)19(8-9-19)14-6-7-14/h14-15H,3-11H2,1-2H3/t15-/m1/s1 NLIMXPGAJBMBAG-OAHLLOKOSA-N 573147 US11453673, Example 9 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 3.73 US Patent 10.7270/Q22Z18RF aid1806837 US11453673 Camp, NP; Hamdouchi, C; Lineswala, JP; Morphy, JR; Shi, Q ELI LILLY AND COMPANY http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=573147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=573147&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 166177409 474495527 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1209471 Cc1c(C)n2c(nnc2c(=O)n1C[C@@H]1CCCCO1)C1(CC1)C1CC1 InChI=1S/C19H26N4O2/c1-12-13(2)23-16(17(24)22(12)11-15-5-3-4-10-25-15)20-21-18(23)19(8-9-19)14-6-7-14/h14-15H,3-11H2,1-2H3/t15-/m0/s1 NLIMXPGAJBMBAG-HNNXBMFYSA-N 573148 US11453673, Example 10 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 6.72 US Patent 10.7270/Q22Z18RF aid1806837 US11453673 Camp, NP; Hamdouchi, C; Lineswala, JP; Morphy, JR; Shi, Q ELI LILLY AND COMPANY http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=573148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=573148&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 166177410 474495528 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1209474 CCC1(CC1)c1nnc2n1c(C)c(C)n(C[C@@H]1CCCCO1)c2=O InChI=1S/C18H26N4O2/c1-4-18(8-9-18)17-20-19-15-16(23)21(12(2)13(3)22(15)17)11-14-7-5-6-10-24-14/h14H,4-11H2,1-3H3/t14-/m0/s1 UFODZZUTBCVMAU-AWEZNQCLSA-N 573149 US11453673, Example 11 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 13.2 US Patent 10.7270/Q22Z18RF aid1806837 US11453673 Camp, NP; Hamdouchi, C; Lineswala, JP; Morphy, JR; Shi, Q ELI LILLY AND COMPANY http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=573149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=573149&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 166177411 474495529 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1209477 CCC1(CC1)c1nnc2n1c(C)c(C)n(C[C@H]1CCCCO1)c2=O InChI=1S/C18H26N4O2/c1-4-18(8-9-18)17-20-19-15-16(23)21(12(2)13(3)22(15)17)11-14-7-5-6-10-24-14/h14H,4-11H2,1-3H3/t14-/m1/s1 UFODZZUTBCVMAU-CQSZACIVSA-N 573150 US11453673, Example 12 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 44.6 US Patent 10.7270/Q22Z18RF aid1806837 US11453673 Camp, NP; Hamdouchi, C; Lineswala, JP; Morphy, JR; Shi, Q ELI LILLY AND COMPANY http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=573150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=573150&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 166177412 474495530 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1209480 Cc1c(C)n2c(nnc2c(=O)n1C[C@@H]1CCCCO1)C1(C)CC1 InChI=1S/C17H24N4O2/c1-11-12(2)21-14(18-19-16(21)17(3)7-8-17)15(22)20(11)10-13-6-4-5-9-23-13/h13H,4-10H2,1-3H3/t13-/m0/s1 HAKBILSEBDWPBF-ZDUSSCGKSA-N 573152 US11453673, Example 13 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 21.8 US Patent 10.7270/Q22Z18RF aid1806837 US11453673 Camp, NP; Hamdouchi, C; Lineswala, JP; Morphy, JR; Shi, Q ELI LILLY AND COMPANY http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=573152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=573152&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 166177414 474495532 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1209483 Cc1c(C)n2c(nnc2c(=O)n1C[C@H]1CCCCO1)C1(C)CC1 InChI=1S/C17H24N4O2/c1-11-12(2)21-14(18-19-16(21)17(3)7-8-17)15(22)20(11)10-13-6-4-5-9-23-13/h13H,4-10H2,1-3H3/t13-/m1/s1 HAKBILSEBDWPBF-CYBMUJFWSA-N 573153 US11453673, Example 14 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 52.4 US Patent 10.7270/Q22Z18RF aid1806837 US11453673 Camp, NP; Hamdouchi, C; Lineswala, JP; Morphy, JR; Shi, Q ELI LILLY AND COMPANY http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=573153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=573153&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 166177415 474495533 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1209486 Cc1c(C)n2c(nnc2c(=O)n1CC1(C)CC1)C1(CC1)C1CC1 InChI=1S/C18H24N4O/c1-11-12(2)22-14(15(23)21(11)10-17(3)6-7-17)19-20-16(22)18(8-9-18)13-4-5-13/h13H,4-10H2,1-3H3 LEQGDWSFJKSNPY-UHFFFAOYSA-N 573154 US11453673, Example 15 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 3.10 US Patent 10.7270/Q22Z18RF aid1806837 US11453673 Camp, NP; Hamdouchi, C; Lineswala, JP; Morphy, JR; Shi, Q ELI LILLY AND COMPANY http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=573154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=573154&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 153334383 474495534 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1209489 CCCCn1c(C)c(CC)n2c(nnc2c1=O)C1(CC1)C1CC1 InChI=1S/C18H26N4O/c1-4-6-11-21-12(3)14(5-2)22-15(16(21)23)19-20-17(22)18(9-10-18)13-7-8-13/h13H,4-11H2,1-3H3 JCDHZZJRTIYJGY-UHFFFAOYSA-N 573155 US11453673, Example 16 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.67 US Patent 10.7270/Q22Z18RF aid1806837 US11453673 Camp, NP; Hamdouchi, C; Lineswala, JP; Morphy, JR; Shi, Q ELI LILLY AND COMPANY http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=573155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=573155&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 166177416 474495535 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1188128 CCCn1c2CCCCc2n2c(nnc2c1=O)C1(CC1)C1CC1 InChI=1S/C18H24N4O/c1-2-11-21-13-5-3-4-6-14(13)22-15(16(21)23)19-20-17(22)18(9-10-18)12-7-8-12/h12H,2-11H2,1H3 ZOYWVKURDMXZTC-UHFFFAOYSA-N 562227 1-([1,1′-bi(cyclopropan)]-1-yl)-5-propyl-6,7,8,9-tetrahydro-[1,2,4]triazolo[4,3-a]quinoxalin-4(5H)-one::US11401274, Example 1 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.90 US Patent 10.7270/Q2DV1P3Z aid1806689 US11401274 Genin, MJ; Holloway, WG; Jesudason, CD; Shi, Q ELI LILLY AND COMPANY http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=562227 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=562227&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 137496847 472623798 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1188131 CCCCn1c2CCCCc2n2c(nnc2c1=O)C1(CC1)C1CC1 InChI=1S/C19H26N4O/c1-2-3-12-22-14-6-4-5-7-15(14)23-16(17(22)24)20-21-18(23)19(10-11-19)13-8-9-13/h13H,2-12H2,1H3 NHHYCGIUZMMXNN-UHFFFAOYSA-N 562228 1-([1,1′-bi(cyclopropan)]-1-yl)-5-butyl-6,7,8,9-tetrahydro-[1,2,4]triazolo[4,3-a]quinoxalin-4(5H)-one::US11401274, Example 2 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 3.00 US Patent 10.7270/Q2DV1P3Z aid1806689 US11401274 Genin, MJ; Holloway, WG; Jesudason, CD; Shi, Q ELI LILLY AND COMPANY http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=562228 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=562228&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 165414706 472623799 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1188134 O=c1n(CC2CC2)c2CCOCc2n2c(nnc12)C1(CC1)C1CC1 InChI=1S/C18H22N4O2/c23-16-15-19-20-17(18(6-7-18)12-3-4-12)22(15)14-10-24-8-5-13(14)21(16)9-11-1-2-11/h11-12H,1-10H2 VGHIZNBWVGBFNE-UHFFFAOYSA-N 562229 1-([1,1′-bi(cyclopropan)]-1-yl)-5-(cyclopropylmethyl)-5,6,7,9-tetrahydro-4H-pyrano[4,3-e][1,2,4]triazolo[4,3-a]pyrazin-4-one::US11401274, Example 3 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 9.80 US Patent 10.7270/Q2DV1P3Z aid1806689 US11401274 Genin, MJ; Holloway, WG; Jesudason, CD; Shi, Q ELI LILLY AND COMPANY http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=562229 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=562229&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 165414707 472623800 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1188137 CCCCn1c2CCOCc2n2c(nnc2c1=O)C1(CC1)C1CC1 InChI=1S/C18H24N4O2/c1-2-3-9-21-13-6-10-24-11-14(13)22-15(16(21)23)19-20-17(22)18(7-8-18)12-4-5-12/h12H,2-11H2,1H3 PPIZHLCUMDEZCN-UHFFFAOYSA-N 562231 1-([1,1′-bi(cyclopropan)]-1-yl)-5-butyl-5,6,7,9-tetrahydro-4H-pyrano[4,3-e][1,2,4]triazolo[4,3-a]pyrazin-4-one::US11401274, Example 4 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 6.30 US Patent 10.7270/Q2DV1P3Z aid1806689 US11401274 Genin, MJ; Holloway, WG; Jesudason, CD; Shi, Q ELI LILLY AND COMPANY http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=562231 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=562231&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 165414708 472623802 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1188140 O=c1n(CC2CCC2)c2CCOCc2n2c(nnc12)C1(CC1)C1CC1 InChI=1S/C19H24N4O2/c24-17-16-20-21-18(19(7-8-19)13-4-5-13)23(16)15-11-25-9-6-14(15)22(17)10-12-2-1-3-12/h12-13H,1-11H2 YXBLPELQAKXZRS-UHFFFAOYSA-N 562235 1-([1,1′-bi(cyclopropan)]-1-yl)-5-(cyclobutylmethyl)-5,6,7,9-tetrahydro-4H-pyrano[4,3-e][1,2,4]triazolo[4,3-a]pyrazin-4-one::US11401274, Example 5 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 5.80 US Patent 10.7270/Q2DV1P3Z aid1806689 US11401274 Genin, MJ; Holloway, WG; Jesudason, CD; Shi, Q ELI LILLY AND COMPANY http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=562235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=562235&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 165414709 472623806 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1188143 O=c1n(CC2CC2)c2COCCc2n2c(nnc12)C1(CC1)C1CC1 InChI=1S/C18H22N4O2/c23-16-15-19-20-17(18(6-7-18)12-3-4-12)22(15)13-5-8-24-10-14(13)21(16)9-11-1-2-11/h11-12H,1-10H2 KPFXUWGXTIMYPE-UHFFFAOYSA-N 562236 1-(1-cyclopropylcyclopropyl)-5-(cyclopropylmethyl)-3-oxo-7,8-dihydro-5H-pyrano-[1,2,4]triazolo[4,3-a]quinoxalin-4-one::US11401274, Example 6 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.40 US Patent 10.7270/Q2DV1P3Z aid1806689 US11401274 Genin, MJ; Holloway, WG; Jesudason, CD; Shi, Q ELI LILLY AND COMPANY http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=562236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=562236&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 165414710 472623807 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1188146 CCCCn1c2COCCc2n2c(nnc2c1=O)C1(CC1)C1CC1 InChI=1S/C18H24N4O2/c1-2-3-9-21-14-11-24-10-6-13(14)22-15(16(21)23)19-20-17(22)18(7-8-18)12-4-5-12/h12H,2-11H2,1H3 OTQSGQJYNNQNSN-UHFFFAOYSA-N 562239 1-([1,1′-bi(cyclopropan)]-1-yl)-5-butyl-8,9-dihydro-6H-pyrano[3,4-e][1,2,4]triazolo[4,3-a]pyrazin-4(5H)-one::US11401274, Example 7 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 5.20 US Patent 10.7270/Q2DV1P3Z aid1806689 US11401274 Genin, MJ; Holloway, WG; Jesudason, CD; Shi, Q ELI LILLY AND COMPANY http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=562239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=562239&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 165414711 472623810 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1188149 O=c1n(CC2CC2)c2CCCCCc2n2c(nnc12)C1(CC1)C1CC1 InChI=1S/C20H26N4O/c25-18-17-21-22-19(20(10-11-20)14-8-9-14)24(17)16-5-3-1-2-4-15(16)23(18)12-13-6-7-13/h13-14H,1-12H2 FOSHUFIWZBKIJO-UHFFFAOYSA-N 562247 1-([1,1′-bi(cyclopropan)]-1-yl)-5-(cyclopropylmethyl)-5,6,7,8,9,10-hexahydro-4H-cyclohepta[e][1,2,4]triazolo[4,3-a]pyrazin-4-one::US11401274, Example 8 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 6.50 US Patent 10.7270/Q2DV1P3Z aid1806689 US11401274 Genin, MJ; Holloway, WG; Jesudason, CD; Shi, Q ELI LILLY AND COMPANY http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=562247 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=562247&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 165414712 472623818 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217064 CCCc1ncc2n1ccn(Cc1cccc(F)c1)c2=O InChI=1S/C16H16FN3O/c1-2-4-15-18-10-14-16(21)19(7-8-20(14)15)11-12-5-3-6-13(17)9-12/h3,5-10H,2,4,11H2,1H3 MUGBFEOWKYVLQV-UHFFFAOYSA-N 474108 7-(3-Fluorobenzyl)-3- propylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 1::US10912773, Example 1::US11472810, Example 1 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 801 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474108&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652260 442074307 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217067 Fc1cccc(Cn2c(Cc3ccccc3)cn3c(ncc3c2=O)C2CCOCC2)c1 InChI=1S/C25H24FN3O2/c26-21-8-4-7-19(13-21)16-28-22(14-18-5-2-1-3-6-18)17-29-23(25(28)30)15-27-24(29)20-9-11-31-12-10-20/h1-8,13,15,17,20H,9-12,14,16H2 NTXQTICQWIKNOO-UHFFFAOYSA-N 474109 6-Benzyl-7-(3-fluorobenzyl)-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 2::US10912773, Example 2::US11472810, Example 2 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 51.0 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474109&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652351 442074308 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217070 O=c1n(CC2CCCCC2)c(Cc2ccccc2)cn2c(ncc12)C1CCOCC1 InChI=1S/C25H31N3O2/c29-25-23-16-26-24(21-11-13-30-14-12-21)28(23)18-22(15-19-7-3-1-4-8-19)27(25)17-20-9-5-2-6-10-20/h1,3-4,7-8,16,18,20-21H,2,5-6,9-15,17H2 DDTRHXHSHXSEDF-UHFFFAOYSA-N 474110 6-Benzyl-7-(cyclohexylmethyl)-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 3::US10912773, Example 3::US11472810, Example 3 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.00 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474110&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652211 442074309 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217073 Cc1cn2c(ncc2c(=O)n1CC1CCCCC1)C1CCOCC1 InChI=1S/C19H27N3O2/c1-14-12-22-17(11-20-18(22)16-7-9-24-10-8-16)19(23)21(14)13-15-5-3-2-4-6-15/h11-12,15-16H,2-10,13H2,1H3 XQZACXVVNPRUIZ-UHFFFAOYSA-N 474111 7-(Cyclohexylmethyl)-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 4::US10912773, Example 4::US11472810, Example 4 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 11.0 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474111&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652213 442074310 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217076 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)C1CCOCC1 InChI=1S/C19H20FN3O2/c1-13-11-23-17(10-21-18(23)15-5-7-25-8-6-15)19(24)22(13)12-14-3-2-4-16(20)9-14/h2-4,9-11,15H,5-8,12H2,1H3 DOTFZTSFGIKARD-UHFFFAOYSA-N 474112 7-(3-Fluorobenzyl)-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 5::US10912773, Example 5::US11472810, Example 5 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 108 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474112&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652328 442074311 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217081 O=c1n(CC2CCCCC2)ccn2c(ncc12)C1CC1 InChI=1S/C16H21N3O/c20-16-14-10-17-15(13-6-7-13)19(14)9-8-18(16)11-12-4-2-1-3-5-12/h8-10,12-13H,1-7,11H2 MVICHLUMJUWVOO-UHFFFAOYSA-N 474115 7-(Cyclohexylmethyl)-3- cyclopropylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 8::US10912773, Example 8::US11472810, Example 8 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 252 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474115&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652314 442074314 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217086 O=c1n(CC2CCCCC2)ccn2c(ncc12)C1CCOCC1 InChI=1S/C18H25N3O2/c22-18-16-12-19-17(15-6-10-23-11-7-15)21(16)9-8-20(18)13-14-4-2-1-3-5-14/h8-9,12,14-15H,1-7,10-11,13H2 XXIPRLNKXMMFIK-UHFFFAOYSA-N 474118 7-(Cyclohexylmethyl)-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 11::US10912773, Example 11::US11472810, Example 11 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 113 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474118&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652369 442074317 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217089 O=c1n(CC2CCCCCC2)ccn2c(ncc12)C1CCOCC1 InChI=1S/C19H27N3O2/c23-19-17-13-20-18(16-7-11-24-12-8-16)22(17)10-9-21(19)14-15-5-3-1-2-4-6-15/h9-10,13,15-16H,1-8,11-12,14H2 SGRJQQJTJHBFTK-UHFFFAOYSA-N 474119 7-(Cycloheptylmethyl)-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 12::US10912773, Example 12::US11472810, Example 12 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 30.0 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474119&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652262 442074318 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217092 O=c1n(CC2CCCCCC2)ccn2c(ncc12)C1CC1 InChI=1S/C17H23N3O/c21-17-15-11-18-16(14-7-8-14)20(15)10-9-19(17)12-13-5-3-1-2-4-6-13/h9-11,13-14H,1-8,12H2 YIBKFYWXALCNMI-UHFFFAOYSA-N 474120 7-(Cycloheptylmethyl)-3- cyclopropylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 13::US10912773, Example 13::US11472810, Example 13 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 87.0 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474120&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652224 442074319 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217095 Cc1cn2c(ncc2c(=O)n1Cc1ccc(Cl)cc1)C1CCOCC1 InChI=1S/C19H20ClN3O2/c1-13-11-23-17(10-21-18(23)15-6-8-25-9-7-15)19(24)22(13)12-14-2-4-16(20)5-3-14/h2-5,10-11,15H,6-9,12H2,1H3 YSJUCDCNAYRULZ-UHFFFAOYSA-N 474121 7-(4-Chlorobenzyl)-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 14::US10912773, Example 14::US11472810, Example 14 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 18.0 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474121&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652230 442074320 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217098 Fc1cccc(Cn2c(Br)cn3c(ncc3c2=O)C2CCOCC2)c1 InChI=1S/C18H17BrFN3O2/c19-16-11-22-15(9-21-17(22)13-4-6-25-7-5-13)18(24)23(16)10-12-2-1-3-14(20)8-12/h1-3,8-9,11,13H,4-7,10H2 JVYBBFBHTBCHNY-UHFFFAOYSA-N 474122 6-Bromo-7-(3-fluorobenzyl)-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 15::US10912773, Example 15::US11472810, Example 15 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 58.0 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474122&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652389 442074321 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217101 Cc1cn2c(ncc2c(=O)n1Cc1ccccc1)C1CCOCC1 InChI=1S/C19H21N3O2/c1-14-12-22-17(11-20-18(22)16-7-9-24-10-8-16)19(23)21(14)13-15-5-3-2-4-6-15/h2-6,11-12,16H,7-10,13H2,1H3 JBXKPHLWRUHDIB-UHFFFAOYSA-N 474123 7-Benzyl-6-methyl-3-(tetrahydro- 2H-pyran-4-yl)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 16::US10912773, Example 16::US11472810, Example 16 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 85.0 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474123&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652416 442074322 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217104 Cc1cn2c(ncc2c(=O)n1Cc1ccccc1F)C1CCOCC1 InChI=1S/C19H20FN3O2/c1-13-11-23-17(10-21-18(23)14-6-8-25-9-7-14)19(24)22(13)12-15-4-2-3-5-16(15)20/h2-5,10-11,14H,6-9,12H2,1H3 SGDZBPUOHUWTHZ-UHFFFAOYSA-N 474124 7-(2-Fluorobenzyl)-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 17::US10912773, Example 17::US11472810, Example 17 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 42.0 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474124&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652218 442074323 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217107 Cc1cn2c(ncc2c(=O)n1Cc1cccc(Cl)c1)C1CCOCC1 InChI=1S/C19H20ClN3O2/c1-13-11-23-17(10-21-18(23)15-5-7-25-8-6-15)19(24)22(13)12-14-3-2-4-16(20)9-14/h2-4,9-11,15H,5-8,12H2,1H3 FRYCFLNTERXYHU-UHFFFAOYSA-N 474125 7-(3-Chlorobenzyl)-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 18::US10912773, Example 18::US11472810, Example 18 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 57.0 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474125&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652215 442074324 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217110 Cc1cn2c(ncc2c(=O)n1Cc1ccccc1Cl)C1CCOCC1 InChI=1S/C19H20ClN3O2/c1-13-11-23-17(10-21-18(23)14-6-8-25-9-7-14)19(24)22(13)12-15-4-2-3-5-16(15)20/h2-5,10-11,14H,6-9,12H2,1H3 RNBCFPQVHXWYQR-UHFFFAOYSA-N 474126 7-(2-Chlorobenzyl)-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 19::US10912773, Example 19::US11472810, Example 19 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 46.0 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474126&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652210 442074325 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217113 COc1cccc(Cn2c(C)cn3c(ncc3c2=O)C2CCOCC2)c1 InChI=1S/C20H23N3O3/c1-14-12-23-18(11-21-19(23)16-6-8-26-9-7-16)20(24)22(14)13-15-4-3-5-17(10-15)25-2/h3-5,10-12,16H,6-9,13H2,1-2H3 OYBSUAILVMFPHS-UHFFFAOYSA-N 474127 7-(3-Methoxybenzyl)-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 20::US10912773, Example 20::US11472810, Example 20 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 416 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474127&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652387 442074326 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217116 Cc1ccccc1Cn1c(C)cn2c(ncc2c1=O)C1CCOCC1 InChI=1S/C20H23N3O2/c1-14-5-3-4-6-17(14)13-22-15(2)12-23-18(20(22)24)11-21-19(23)16-7-9-25-10-8-16/h3-6,11-12,16H,7-10,13H2,1-2H3 ICFZMMURQAUHKS-UHFFFAOYSA-N 474128 6-Methyl-7-(2-methylbenzyl)-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 21::US10912773, Example 21::US11472810, Example 21 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 242 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474128&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652209 442074327 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217119 Cc1ccc(Cn2c(C)cn3c(ncc3c2=O)C2CCOCC2)cc1 InChI=1S/C20H23N3O2/c1-14-3-5-16(6-4-14)13-22-15(2)12-23-18(20(22)24)11-21-19(23)17-7-9-25-10-8-17/h3-6,11-12,17H,7-10,13H2,1-2H3 NJLBYLKOKZGPPW-UHFFFAOYSA-N 474129 6-Methyl-7-(4-methylbenzyl)-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 22::US10912773, Example 22::US11472810, Example 22 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 75.0 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474129&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652392 442074328 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217122 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C2CCOCC2)cc1 InChI=1S/C20H23N3O3/c1-14-12-23-18(11-21-19(23)16-7-9-26-10-8-16)20(24)22(14)13-15-3-5-17(25-2)6-4-15/h3-6,11-12,16H,7-10,13H2,1-2H3 PUKNFFAMUWZTGI-UHFFFAOYSA-N 474130 7-(4-Methoxybenzyl)-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 23::US10912773, Example 23::US11472810, Example 23 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 14.0 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474130 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474130&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652249 442074329 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217125 Cc1cn2c(ncc2c(=O)n1Cc1ccc(F)cc1)C1CCOCC1 InChI=1S/C19H20FN3O2/c1-13-11-23-17(10-21-18(23)15-6-8-25-9-7-15)19(24)22(13)12-14-2-4-16(20)5-3-14/h2-5,10-11,15H,6-9,12H2,1H3 HTAKTLWSUKQRRS-UHFFFAOYSA-N 474131 7-(4-Fluorobenzyl)-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 24::US10912773, Example 24::US11472810, Example 24 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 38.0 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474131&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652282 442074330 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217128 Cc1cccc(Cn2c(C)cn3c(ncc3c2=O)C2CCOCC2)c1 InChI=1S/C20H23N3O2/c1-14-4-3-5-16(10-14)13-22-15(2)12-23-18(20(22)24)11-21-19(23)17-6-8-25-9-7-17/h3-5,10-12,17H,6-9,13H2,1-2H3 FCLGCXKNDLJHGE-UHFFFAOYSA-N 474132 6-Methyl-7-(3-methylbenzyl)-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 25::US10912773, Example 25::US11472810, Example 25 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 63.0 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474132&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652311 442074331 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217131 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)C1(C)CCOCC1 InChI=1S/C20H22FN3O2/c1-14-12-24-17(11-22-19(24)20(2)6-8-26-9-7-20)18(25)23(14)13-15-4-3-5-16(21)10-15/h3-5,10-12H,6-9,13H2,1-2H3 MVBCAJXPQPBVSA-UHFFFAOYSA-N 474133 7-(3-fluorobenzyl)-6-methyl-3-(4- methyltetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 26::US10912773, Example 26::US11472810, Example 26 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 234 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474133&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652437 442074332 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217134 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)C1(CCOCC1)C#N InChI=1S/C20H19FN4O2/c1-14-11-25-17(10-23-19(25)20(13-22)5-7-27-8-6-20)18(26)24(14)12-15-3-2-4-16(21)9-15/h2-4,9-11H,5-8,12H2,1H3 USXLZPZGBIYQLQ-UHFFFAOYSA-N 474134 4-(7-(3-fluorobenzyl)-6-methyl-8- oxo-7,8-dihydroimidazo[1,5- a]pyrazin-3-yl)tetrahydro-2H- pyran-4-carbonitrile::US10858362, Example 27::US10912773, Example 27::US11472810, Example 27 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 603 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474134&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652325 442074333 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217137 COC1(CCOCC1)c1ncc2n1cc(C)n(Cc1cccc(F)c1)c2=O InChI=1S/C20H22FN3O3/c1-14-12-24-17(11-22-19(24)20(26-2)6-8-27-9-7-20)18(25)23(14)13-15-4-3-5-16(21)10-15/h3-5,10-12H,6-9,13H2,1-2H3 ZCVGFCXGAGKYHH-UHFFFAOYSA-N 474135 7-(3-fluorobenzyl)-3-(4- methoxytetrahydro-2H-pyran-4- yl)-6-methylimidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 28::US10912773, Example 28::US11472810, Example 28 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 663 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474135&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652291 442074334 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217140 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)C1(F)CCOCC1 InChI=1S/C19H19F2N3O2/c1-13-11-24-16(10-22-18(24)19(21)5-7-26-8-6-19)17(25)23(13)12-14-3-2-4-15(20)9-14/h2-4,9-11H,5-8,12H2,1H3 RQWUWJPTWQLWON-UHFFFAOYSA-N 474136 7-(3-fluorobenzyl)-3-(4- fluorotetrahydro-2H-pyran-4-yl)- 6-methylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 29::US10912773, Example 29::US11472810, Example 29 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 493 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474136&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652263 442074335 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217146 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)[C@@H]1CCOC1 InChI=1S/C18H18FN3O2/c1-12-9-22-16(8-20-17(22)14-5-6-24-11-14)18(23)21(12)10-13-3-2-4-15(19)7-13/h2-4,7-9,14H,5-6,10-11H2,1H3/t14-/m1/s1 LEYPTBGWIKQYRW-CQSZACIVSA-N 474139 7-(3-fluorobenzyl)-6-methyl-3- (tetrahydrofuran-3-yl)imidazo[1,5- a]pyrazin-8(7H)-one, stereoisomer 1::US10858362, Example 31, isomer 1::US10905688, Example 31, isomer 1::US11472810, Example 31, isomer 1 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 337 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474139&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652497 442074338 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217149 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)[C@H]1CCOC1 InChI=1S/C18H18FN3O2/c1-12-9-22-16(8-20-17(22)14-5-6-24-11-14)18(23)21(12)10-13-3-2-4-15(19)7-13/h2-4,7-9,14H,5-6,10-11H2,1H3/t14-/m0/s1 LEYPTBGWIKQYRW-AWEZNQCLSA-N 474140 7-(3-fluorobenzyl)-6-methyl-3- (tetrahydrofuran-3-yl)imidazo[1,5- a]pyrazin-8(7H)-one, stereoisomer 2::US10858362, Example 31, isomer 2::US10912773, Example 31-isomer-2::US11472810, Example 31, isomer 2 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 347 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474140 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474140&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652532 442074339 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217152 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)[C@@]1(C)CCOC1 InChI=1S/C19H20FN3O2/c1-13-10-23-16(9-21-18(23)19(2)6-7-25-12-19)17(24)22(13)11-14-4-3-5-15(20)8-14/h3-5,8-10H,6-7,11-12H2,1-2H3/t19-/m0/s1 AQLHITNAEZNQJK-IBGZPJMESA-N 474142 7-(3-fluorobenzyl)-6-methyl-3-(3- methyltetrahydrofuran-3- yl)imidazo[1,5-a]pyrazin-8(7H)- one, stereoisomer 2::US10858362, Example 32, isomer 2::US10912773, Example 32-isomer-2::US11472810, Example 32, isomer 1 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 257 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474142&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652347 442074341 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217155 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)[C@]1(C)CCOC1 InChI=1S/C19H20FN3O2/c1-13-10-23-16(9-21-18(23)19(2)6-7-25-12-19)17(24)22(13)11-14-4-3-5-15(20)8-14/h3-5,8-10H,6-7,11-12H2,1-2H3/t19-/m1/s1 AQLHITNAEZNQJK-LJQANCHMSA-N 474141 7-(3-fluorobenzyl)-6-methyl-3-(3- methyltetrahydrofuran-3- yl)imidazo[1,5-a]pyrazin-8(7H)- one, stereoisomer 1::US10858362, Example 32, isomer 1::US10912773, Example 32-isomer-1::US11472810, Example 32, isomer 2 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 401 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474141 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474141&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652541 442074340 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217158 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)C1(C)CC1 InChI=1S/C18H18FN3O/c1-12-10-22-15(9-20-17(22)18(2)6-7-18)16(23)21(12)11-13-4-3-5-14(19)8-13/h3-5,8-10H,6-7,11H2,1-2H3 VCCNMXVKDHUXGT-UHFFFAOYSA-N 474143 7-(3-fluorobenzyl)-6-methyl-3-(1- methylcyclopropyl)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 33::US10912773, Example 33::US11472810, Example 33 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 94.0 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474143 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474143&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652394 442074342 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217161 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)C1CC1(F)F InChI=1S/C17H14F3N3O/c1-10-8-23-14(7-21-15(23)13-6-17(13,19)20)16(24)22(10)9-11-3-2-4-12(18)5-11/h2-5,7-8,13H,6,9H2,1H3 GEKRVCRUZXROSZ-UHFFFAOYSA-N 474144 3-(2,2-difluorocyclopropyl)-7-(3- fluorobenzyl)-6- methylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 34::US10905688, Example 34::US11472810, Example 34 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 331 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474144&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652478 442074343 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217164 C[C@H]1C[C@H]1c1ncc2n1cc(C)n(Cc1cccc(F)c1)c2=O InChI=1S/C18H18FN3O/c1-11-6-15(11)17-20-8-16-18(23)21(12(2)9-22(16)17)10-13-4-3-5-14(19)7-13/h3-5,7-9,11,15H,6,10H2,1-2H3/t11-,15+/m0/s1 NSFYZWGFIIQKQP-XHDPSFHLSA-N 474145 7-(3-fluorobenzyl)-6-methyl-3-(2- methylcyclopropyl)imidazo[1,5- a]pyrazin-8(7H)-one, stereoisomer 1::US10858362, Example 35, isomer 1::US10912773, Example 35-isomer-1::US11472810, Example 35, isomer 1 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 193 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474145&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652399 442074344 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217167 C[C@@H]1C[C@H]1c1ncc2n1cc(C)n(Cc1cccc(F)c1)c2=O InChI=1S/C18H18FN3O/c1-11-6-15(11)17-20-8-16-18(23)21(12(2)9-22(16)17)10-13-4-3-5-14(19)7-13/h3-5,7-9,11,15H,6,10H2,1-2H3/t11-,15-/m1/s1 NSFYZWGFIIQKQP-IAQYHMDHSA-N 474146 7-(3-fluorobenzyl)-6-methyl-3-(2- methylcyclopropyl)imidazo[1,5- a]pyrazin-8(7H)-one, stereoisomer 2::US10858362, Example 35, isomer 2::US10912773, Example 35-isomer-3::US11472810, Example 35, isomer 2 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 364 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474146&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652492 442074345 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217170 C[C@H]1C[C@@H]1c1ncc2n1cc(C)n(Cc1cccc(F)c1)c2=O InChI=1S/C18H18FN3O/c1-11-6-15(11)17-20-8-16-18(23)21(12(2)9-22(16)17)10-13-4-3-5-14(19)7-13/h3-5,7-9,11,15H,6,10H2,1-2H3/t11-,15-/m0/s1 NSFYZWGFIIQKQP-NHYWBVRUSA-N 474147 7-(3-fluorobenzyl)-6-methyl-3-(2- methylcyclopropyl)imidazo[1,5- a]pyrazin-8(7H)-one, stereoisomer 3::US10858362, Example 35, isomer 3::US10905688, Example 35, isomer 3::US11472810, Example 35, isomer 3 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 82.0 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474147&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652536 442074346 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217175 C[C@H]1OCC[C@H]1c1ncc2n1cc(C)n(Cc1cccc(F)c1)c2=O InChI=1S/C19H20FN3O2/c1-12-10-23-17(9-21-18(23)16-6-7-25-13(16)2)19(24)22(12)11-14-4-3-5-15(20)8-14/h3-5,8-10,13,16H,6-7,11H2,1-2H3/t13-,16-/m1/s1 BZFPDTIGFMRZDI-CZUORRHYSA-N 474149 7-(3-fluorobenzyl)-6-methyl-3-(2- methyltetrahydrofuran-3- yl)imidazo[1,5-a]pyrazin-8(7H)- one, stereoisomer 1::US10858362, Example 36, isomer 1::US10912773, Example 36-isomer-1::US11472810, Example 36, isomer 1 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 152 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474149&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652377 442074348 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217178 C[C@@H]1OCC[C@H]1c1ncc2n1cc(C)n(Cc1cccc(F)c1)c2=O InChI=1S/C19H20FN3O2/c1-12-10-23-17(9-21-18(23)16-6-7-25-13(16)2)19(24)22(12)11-14-4-3-5-15(20)8-14/h3-5,8-10,13,16H,6-7,11H2,1-2H3/t13-,16+/m0/s1 BZFPDTIGFMRZDI-XJKSGUPXSA-N 474151 7-(3-fluorobenzyl)-6-methyl-3-(2- methyltetrahydrofuran-3- yl)imidazo[1,5-a]pyrazin-8(7H)- one, stereoisomer 3::US10858362, Example 36, isomer 3::US10912773, Example 36-isomer-3::US11472810, Example 36, isomer 2 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 282 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474151 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474151&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652488 442074350 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217181 C[C@H]1OCC[C@@H]1c1ncc2n1cc(C)n(Cc1cccc(F)c1)c2=O InChI=1S/C19H20FN3O2/c1-12-10-23-17(9-21-18(23)16-6-7-25-13(16)2)19(24)22(12)11-14-4-3-5-15(20)8-14/h3-5,8-10,13,16H,6-7,11H2,1-2H3/t13-,16+/m1/s1 BZFPDTIGFMRZDI-CJNGLKHVSA-N 474150 7-(3-fluorobenzyl)-6-methyl-3-(2- methyltetrahydrofuran-3- yl)imidazo[1,5-a]pyrazin-8(7H)- one, stereoisomer 2::US10858362, Example 36, isomer 2::US10912773, Example 36-isomer-2::US11472810, Example 36, isomer 3 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 77.0 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474150&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652487 442074349 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217184 C[C@@H]1OCC[C@@H]1c1ncc2n1cc(C)n(Cc1cccc(F)c1)c2=O InChI=1S/C19H20FN3O2/c1-12-10-23-17(9-21-18(23)16-6-7-25-13(16)2)19(24)22(12)11-14-4-3-5-15(20)8-14/h3-5,8-10,13,16H,6-7,11H2,1-2H3/t13-,16-/m0/s1 BZFPDTIGFMRZDI-BBRMVZONSA-N 474152 7-(3-fluorobenzyl)-6-methyl-3-(2- methyltetrahydrofuran-3- yl)imidazo[1,5-a]pyrazin-8(7H)- one, stereoisomer 4::US10858362, Example 36, isomer 4::US10912773, Example 36-isomer-4::US11472810, Example 36, isomer 4 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 51.0 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474152&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652474 442074351 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217186 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)[C@@H]1C[C@@H]1F InChI=1S/C17H15F2N3O/c1-10-8-22-15(7-20-16(22)13-6-14(13)19)17(23)21(10)9-11-3-2-4-12(18)5-11/h2-5,7-8,13-14H,6,9H2,1H3/t13-,14+/m1/s1 MVVQNOPLTGEXNR-KGLIPLIRSA-N 480821 7-(3-fluorobenzyl)-3-(cis-2- methylimidazo[1,5-a]pyrazin- 8(7H)-one, stereoisomer 1::US10905688, Example 37, isomer 1::US11472810, Example 37, isomer 1 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1140 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=480821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=480821&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652268 443550013 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217189 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)[C@H]1C[C@@H]1F InChI=1S/C17H15F2N3O/c1-10-8-22-15(7-20-16(22)13-6-14(13)19)17(23)21(10)9-11-3-2-4-12(18)5-11/h2-5,7-8,13-14H,6,9H2,1H3/t13-,14-/m0/s1 MVVQNOPLTGEXNR-KBPBESRZSA-N 474155 7-(3-fluorobenzyl)-3-(trans-2- fluorocyclopropyl)-6- methylimidazo[1,5-a]pyrazin- 8(7H)-one, stereoisomer 1::US10858362, Example 38, isomer 1::US10905688, Example 37, isomer 2::US11472810, Example 37, isomer 2 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 149 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474155&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652432 442074354 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217192 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)[C@H]1C[C@H]1F InChI=1S/C17H15F2N3O/c1-10-8-22-15(7-20-16(22)13-6-14(13)19)17(23)21(10)9-11-3-2-4-12(18)5-11/h2-5,7-8,13-14H,6,9H2,1H3/t13-,14+/m0/s1 MVVQNOPLTGEXNR-UONOGXRCSA-N 474156 7-(3-fluorobenzyl)-3-(trans-2- fluorocyclopropyl)-6- methylimidazo[1,5-a]pyrazin- 8(7H)-one, stereoisomer 2::US10858362, Example 38, isomer 2::US10905688, Example 38, isomer 2::US11472810, Example 38, isomer 2 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 667 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474156&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652469 442074355 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217195 Cc1cn2c(ncc2c(=O)n1Cc1ccc(OC2CC2)cc1)C1CCOCC1 InChI=1S/C22H25N3O3/c1-15-13-25-20(12-23-21(25)17-8-10-27-11-9-17)22(26)24(15)14-16-2-4-18(5-3-16)28-19-6-7-19/h2-5,12-13,17,19H,6-11,14H2,1H3 RVWGYNGTLDYNPU-UHFFFAOYSA-N 474157 7-(4-cyclopropoxybenzyl)-6- methyl-3-(tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 39::US10912773, Example 39::US11472810, Example 39 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 413 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474157&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652459 442074356 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217198 Cc1cn2c(ncc2c(=O)n1Cc1ccc(OC(F)F)cc1)C1CCOCC1 InChI=1S/C20H21F2N3O3/c1-13-11-25-17(10-23-18(25)15-6-8-27-9-7-15)19(26)24(13)12-14-2-4-16(5-3-14)28-20(21)22/h2-5,10-11,15,20H,6-9,12H2,1H3 QPWYRFGVZKZRGE-UHFFFAOYSA-N 474158 7-(4-(difluoromethoxy)benzyl)-6- methyl-3-(tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 40::US10912773, Example 40::US11472810, Example 40 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 73.0 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474158&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652417 442074357 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217201 Cc1cn2c(ncc2c(=O)n1Cc1ccc(OC(F)(F)F)cc1)C1CCOCC1 InChI=1S/C20H20F3N3O3/c1-13-11-26-17(10-24-18(26)15-6-8-28-9-7-15)19(27)25(13)12-14-2-4-16(5-3-14)29-20(21,22)23/h2-5,10-11,15H,6-9,12H2,1H3 UNRQWEFTRALILW-UHFFFAOYSA-N 474159 6-methyl-3-(tetrahydro-2H-pyran- 4-yl)-7-(4- (trifluoromethoxy)benzyl)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 41::US10912773, Example 41::US11472810, Example 41 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 27.0 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474159&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652254 442074358 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217205 CCc1cn2c(ncc2c(=O)n1Cc1ccccc1)C1CCOCC1 InChI=1S/C20H23N3O2/c1-2-17-14-23-18(12-21-19(23)16-8-10-25-11-9-16)20(24)22(17)13-15-6-4-3-5-7-15/h3-7,12,14,16H,2,8-11,13H2,1H3 LEQLMZLBAGAUDL-UHFFFAOYSA-N 474161 7-benzyl-6-ethyl-3-(tetrahydro- 2H-pyran-4-yl)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 43::US10912773, Example 43::US11472810, Example 43 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 105 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474161&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652424 442074360 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217208 CCc1cn2c(ncc2c(=O)n1Cc1ccc(OC)cc1)C1CCOCC1 InChI=1S/C21H25N3O3/c1-3-17-14-24-19(12-22-20(24)16-8-10-27-11-9-16)21(25)23(17)13-15-4-6-18(26-2)7-5-15/h4-7,12,14,16H,3,8-11,13H2,1-2H3 IHHHPGCUSMYQHX-UHFFFAOYSA-N 474162 6-ethyl-7-(4-methoxybenzyl)-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 44::US10912773, Example 44::US11472810, Example 44 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 40.0 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474162&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652232 442074361 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217211 Cc1cn2c(ncc2c(=O)n1Cc1cccc(c1)C#N)C1CCOCC1 InChI=1S/C20H20N4O2/c1-14-12-24-18(11-22-19(24)17-5-7-26-8-6-17)20(25)23(14)13-16-4-2-3-15(9-16)10-21/h2-4,9,11-12,17H,5-8,13H2,1H3 HBKUUJGKQVTMIE-UHFFFAOYSA-N 474163 3-((6-methyl-8-oxo-3-(tetrahydro- 2H-pyran-4-yl)imidazo[1,5- a]pyrazin-7(8H)- yl)methyl)benzonitrile::US10858362, Example 45::US10912773, Example 45::US11472810, Example 45 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 64.0 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474163&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652242 442074362 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217213 Cc1cn2c(ncc2c(=O)n1Cc1ccc(cc1)C#N)C1CCOCC1 InChI=1S/C20H20N4O2/c1-14-12-24-18(11-22-19(24)17-6-8-26-9-7-17)20(25)23(14)13-16-4-2-15(10-21)3-5-16/h2-5,11-12,17H,6-9,13H2,1H3 LQAZSSIUEDYCBP-UHFFFAOYSA-N 474164 4-((6-methyl-8-oxo-3-(tetrahydro- 2H-pyran-4-yl)imidazo[1,5- a]pyrazin-7(8H)- yl)methyl)benzonitrile::US10858362, Example 46::US10912773, Example 46::US11472810, Example 46 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 809 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474164&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652248 442074363 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217215 CCc1ccccc1Cn1c(C)cn2c(ncc2c1=O)C1CCOCC1 InChI=1S/C21H25N3O2/c1-3-16-6-4-5-7-18(16)14-23-15(2)13-24-19(21(23)25)12-22-20(24)17-8-10-26-11-9-17/h4-7,12-13,17H,3,8-11,14H2,1-2H3 HLXDXKMIVTXPEU-UHFFFAOYSA-N 474166 7-(2-ethylbenzyl)-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 49::US10912773, Example 49::US11472810, Example 49 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 44.0 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474166&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652447 442074365 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217217 Cc1cn2c(ncc2c(=O)n1Cc1ccc2OCOc2c1)C1CCOCC1 InChI=1S/C20H21N3O4/c1-13-10-23-16(9-21-19(23)15-4-6-25-7-5-15)20(24)22(13)11-14-2-3-17-18(8-14)27-12-26-17/h2-3,8-10,15H,4-7,11-12H2,1H3 ZABNCYCWYYVHOF-UHFFFAOYSA-N 474167 7-(benzo[d][1,3]dioxol-5- ylmethyl)-6-methyl-3-(tetrahydro- 2H-pyran-4-yl)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 50::US10912773, Example 50::US11472810, Example 50 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 50.0 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474167 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474167&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652367 442074366 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217220 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C2CCOCC2)cc1Cl InChI=1S/C20H22ClN3O3/c1-13-11-24-17(10-22-19(24)15-5-7-27-8-6-15)20(25)23(13)12-14-3-4-18(26-2)16(21)9-14/h3-4,9-11,15H,5-8,12H2,1-2H3 AKDKVOQBJMHADC-UHFFFAOYSA-N 474168 7-(3-chloro-4-methoxybenzyl)-6- methyl-3-(tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 51::US10912773, Example 51::US11472810, Example 51 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 199 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474168&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652468 442074367 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217224 Cc1cn2c(ncc2c(=O)n1Cc1ccc(O)cc1)C1CCOCC1 InChI=1S/C19H21N3O3/c1-13-11-22-17(10-20-18(22)15-6-8-25-9-7-15)19(24)21(13)12-14-2-4-16(23)5-3-14/h2-5,10-11,15,23H,6-9,12H2,1H3 HWZIGTUHYHCMIT-UHFFFAOYSA-N 474170 7-(4-hydroxybenzyl)-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 53::US10912773, Example 53::US11472810, Example 53 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 401 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474170&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652448 442074369 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217227 CCc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)C1CCOCC1 InChI=1S/C20H22FN3O2/c1-2-17-13-24-18(11-22-19(24)15-6-8-26-9-7-15)20(25)23(17)12-14-4-3-5-16(21)10-14/h3-5,10-11,13,15H,2,6-9,12H2,1H3 AFONMYZRPMFJAB-UHFFFAOYSA-N 474171 6-ethyl-7-(3-fluorobenzyl)-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 54::US10912773, Example 54::US11472810, Example 54 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 62.0 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474171&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652310 442074370 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217230 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)[C@@H]2CCO[C@@H]2C)cc1 InChI=1S/C20H23N3O3/c1-13-11-23-18(10-21-19(23)17-8-9-26-14(17)2)20(24)22(13)12-15-4-6-16(25-3)7-5-15/h4-7,10-11,14,17H,8-9,12H2,1-3H3/t14-,17-/m1/s1 PZHZVFDPQAUVKV-RHSMWYFYSA-N 474172 7-(4-methoxybenzyl)-6-methyl-3- (2-methyltetrahydrofuran-3- yl)imidazo[1,5-a]pyrazin-8(7H)- one, stereoisomer 1::US10858362, Example 55, isomer 1::US10912773, Example 55-isomer-1::US11472810, Example 55, isomer 1 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 20.0 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474172 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474172&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652364 442074371 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217233 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)[C@@H]2CCO[C@H]2C)cc1 InChI=1S/C20H23N3O3/c1-13-11-23-18(10-21-19(23)17-8-9-26-14(17)2)20(24)22(13)12-15-4-6-16(25-3)7-5-15/h4-7,10-11,14,17H,8-9,12H2,1-3H3/t14-,17+/m0/s1 PZHZVFDPQAUVKV-WMLDXEAASA-N 474173 7-(4-methoxybenzyl)-6-methyl-3- (2-methyltetrahydrofuran-3- yl)imidazo[1,5-a]pyrazin-8(7H)- one, stereoisomer 2::US10858362, Example 55, isomer 2::US10858362, Example 55, isomer 3::US10912773, Example 55-isomer-2::US11472810, Example 55, isomer 2 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 86.0 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474173&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652531 442074372 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217236 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)[C@H]2CCO[C@@H]2C)cc1 InChI=1S/C20H23N3O3/c1-13-11-23-18(10-21-19(23)17-8-9-26-14(17)2)20(24)22(13)12-15-4-6-16(25-3)7-5-15/h4-7,10-11,14,17H,8-9,12H2,1-3H3/t14-,17+/m1/s1 PZHZVFDPQAUVKV-PBHICJAKSA-N 480842 7-(4-methoxybenzyl)-6-methyl-3- yl)imidazo[1,5-a]pyrazin-8(7H)- one, stereoisomer 3::US10905688, Example 55, isomer 3::US11472810, Example 55, isomer 3 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 13.0 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=480842 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=480842&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652462 443550034 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217239 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)[C@H]2CCO[C@H]2C)cc1 InChI=1S/C20H23N3O3/c1-13-11-23-18(10-21-19(23)17-8-9-26-14(17)2)20(24)22(13)12-15-4-6-16(25-3)7-5-15/h4-7,10-11,14,17H,8-9,12H2,1-3H3/t14-,17-/m0/s1 PZHZVFDPQAUVKV-YOEHRIQHSA-N 474175 7-(4-methoxybenzyl)-6-methyl-3- (2-methyltetrahydrofuran-3- yl)imidazo[1,5-a]pyrazin-8(7H)- one, stereoisomer 4::US10858362, Example 55, isomer 4::US10905688, Example 55, isomer 4::US11472810, Example 55, isomer 4 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 137 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474175 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474175&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652443 442074373 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217242 CCCc1ncc2n1cc(C)n(Cc1ccc(OC)cc1)c2=O InChI=1S/C18H21N3O2/c1-4-5-17-19-10-16-18(22)20(13(2)11-21(16)17)12-14-6-8-15(23-3)9-7-14/h6-11H,4-5,12H2,1-3H3 YMHRUXWRFFVZTC-UHFFFAOYSA-N 474176 7-(4-methoxybenzyl)-6-methyl-3- propylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 56::US10912773, Example 56::US11472810, Example 56 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 65.0 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474176 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474176&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652426 442074374 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217245 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C2CCOCC2)cn1 InChI=1S/C19H22N4O3/c1-13-11-23-16(10-21-18(23)15-5-7-26-8-6-15)19(24)22(13)12-14-3-4-17(25-2)20-9-14/h3-4,9-11,15H,5-8,12H2,1-2H3 OVPVMIDVNMKKNU-UHFFFAOYSA-N 474177 7-((6-methoxypyridin-3- yl)methyl)-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 57::US10912773, Example 57::US11472810, Example 57 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 45.0 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474177 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474177&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652538 442074375 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217249 CCn1c(C)cn2c(ncc2c1=O)C1CCOCC1 InChI=1S/C14H19N3O2/c1-3-16-10(2)9-17-12(14(16)18)8-15-13(17)11-4-6-19-7-5-11/h8-9,11H,3-7H2,1-2H3 WESIRYTURBTMCP-UHFFFAOYSA-N 474179 7-ethyl-6-methyl-3-(tetrahydro- 2H-pyran-4-yl)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 59::US10912773, Example 59::US11472810, Example 59 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2333 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474179 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474179&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652457 442074377 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217252 CCCn1c(C)cn2c(ncc2c1=O)C1CCOCC1 InChI=1S/C15H21N3O2/c1-3-6-17-11(2)10-18-13(15(17)19)9-16-14(18)12-4-7-20-8-5-12/h9-10,12H,3-8H2,1-2H3 ARICWMJJQKCTDR-UHFFFAOYSA-N 474180 6-methyl-7-propyl-3-(tetrahydro- 2H-pyran-4-yl)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 60::US10912773, Example 60::US11472810, Example 60 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 810 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474180 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474180&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652455 442074378 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217255 CC(C)CCn1c(C)cn2c(ncc2c1=O)C1CCOCC1 InChI=1S/C17H25N3O2/c1-12(2)4-7-19-13(3)11-20-15(17(19)21)10-18-16(20)14-5-8-22-9-6-14/h10-12,14H,4-9H2,1-3H3 OEYDINZBWMRAIK-UHFFFAOYSA-N 474181 7-isopentyl-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 62::US10912773, Example 62::US11472810, Example 62 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1078 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474181&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652305 442074379 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217258 Cc1cn2c(ncc2c(=O)n1CC1CCCC1)C1CCOCC1 InChI=1S/C18H25N3O2/c1-13-11-21-16(10-19-17(21)15-6-8-23-9-7-15)18(22)20(13)12-14-4-2-3-5-14/h10-11,14-15H,2-9,12H2,1H3 IVIOKHSMYSCNPJ-UHFFFAOYSA-N 474182 7-(cyclopentylmethyl)-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 63::US10912773, Example 63::US11472810, Example 63 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 183 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474182 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474182&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652331 442074380 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217261 Cc1cn2c(ncc2c(=O)n1Cc1ccccc1C#N)C1CCOCC1 InChI=1S/C20H20N4O2/c1-14-12-24-18(11-22-19(24)15-6-8-26-9-7-15)20(25)23(14)13-17-5-3-2-4-16(17)10-21/h2-5,11-12,15H,6-9,13H2,1H3 ISOFGIBMBLOJRH-UHFFFAOYSA-N 474183 2-((6-methyl-8-oxo-3-(tetrahydro- 2H-pyran-4-yl)imidazo[1,5- a]pyrazin-7(8H)- yl)methyl)benzonitrile::US10858362, Example 64::US10912773, Example 64::US11472810, Example 64 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 624 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474183&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652237 442074381 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217264 Cc1cn2c(ncc2c(=O)n1CC1CCCCCC1)C1CCOCC1 InChI=1S/C20H29N3O2/c1-15-13-23-18(12-21-19(23)17-8-10-25-11-9-17)20(24)22(15)14-16-6-4-2-3-5-7-16/h12-13,16-17H,2-11,14H2,1H3 FIIDAEWKLGRESO-UHFFFAOYSA-N 474184 7-(cycloheptylmethyl)-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 65::US10912773, Example 65::US11472810, Example 65 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 10.00 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474184 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474184&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652324 442074382 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217267 CO[C@@H]1CC[C@H](Cn2c(C)cn3c(ncc3c2=O)C2CCOCC2)CC1 InChI=1S/C20H29N3O3/c1-14-12-23-18(11-21-19(23)16-7-9-26-10-8-16)20(24)22(14)13-15-3-5-17(25-2)6-4-15/h11-12,15-17H,3-10,13H2,1-2H3/t15-,17+ RPFGNHZGIBGJKF-WOVMCDHWSA-N 474187 7-(((cis)-4- methoxycyclohexyl)methyl)-6- methyl-3-(tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 67::US11472810, Example 67 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 234 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474187 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474187&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652247 442074384 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217270 CO[C@H]1CC[C@H](Cn2c(C)cn3c(ncc3c2=O)C2CCOCC2)CC1 InChI=1S/C20H29N3O3/c1-14-12-23-18(11-21-19(23)16-7-9-26-10-8-16)20(24)22(14)13-15-3-5-17(25-2)6-4-15/h11-12,15-17H,3-10,13H2,1-2H3/t15-,17- RPFGNHZGIBGJKF-JCNLHEQBSA-N 474188 7-(((trans)-4- methoxycyclohexyl)methyl)-6- methyl-3-(tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 68::US11472810, Example 68 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 323 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474188 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474188&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652247 442074385 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217273 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C2CCOCC2C)cc1 InChI=1S/C21H25N3O3/c1-14-13-27-9-8-18(14)20-22-10-19-21(25)23(15(2)11-24(19)20)12-16-4-6-17(26-3)7-5-16/h4-7,10-11,14,18H,8-9,12-13H2,1-3H3 YTOUKKHZMQVQLZ-UHFFFAOYSA-N 474189 7-(4-methoxybenzyl)-6-methyl-3- (3-methyltetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 69::US10912773, Example 69::US11472810, Example 69 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 13.0 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474189&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652323 442074386 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217276 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C2(C)CC3CCC2O3)cc1 InChI=1S/C22H25N3O3/c1-14-12-25-18(11-23-21(25)22(2)10-17-8-9-19(22)28-17)20(26)24(14)13-15-4-6-16(27-3)7-5-15/h4-7,11-12,17,19H,8-10,13H2,1-3H3 NRIDLTZEDZLZBY-UHFFFAOYSA-N 474190 7-(4-methoxybenzyl)-6-methyl-3- ((1R,2R,4S)-2-methyl-7- oxabicyclo[2.2.1]heptan-2- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 70::US10912773, Example 70::US11472810, Example 70 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 29.0 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474190 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474190&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122663821 442074387 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217279 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)[C@@H](C)c2ccccc2)cc1 InChI=1S/C23H23N3O2/c1-16-14-26-21(13-24-22(26)17(2)19-7-5-4-6-8-19)23(27)25(16)15-18-9-11-20(28-3)12-10-18/h4-14,17H,15H2,1-3H3/t17-/m0/s1 SWHFTCTZWOUUQD-KRWDZBQOSA-N 474191 (S)-7-(4-methoxybenzyl)-6- methyl-3-(1- phenylethyl)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 71::US10912773, Example 71::US11472810, Example 71 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 211 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474191 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474191&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652214 442074388 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217282 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)[C@H](C)c2ccccc2)cc1 InChI=1S/C23H23N3O2/c1-16-14-26-21(13-24-22(26)17(2)19-7-5-4-6-8-19)23(27)25(16)15-18-9-11-20(28-3)12-10-18/h4-14,17H,15H2,1-3H3/t17-/m1/s1 SWHFTCTZWOUUQD-QGZVFWFLSA-N 474192 (R)-7-(4-methoxybenzyl)-6- methyl-3-(1- phenylethyl)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 72::US10912773, Example 72::US11472810, Example 72 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 90.0 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474192&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652402 442074389 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217285 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C2(C)CCN(C)CC2)cc1 InChI=1S/C22H28N4O2/c1-16-14-26-19(13-23-21(26)22(2)9-11-24(3)12-10-22)20(27)25(16)15-17-5-7-18(28-4)8-6-17/h5-8,13-14H,9-12,15H2,1-4H3 UOMHYPRQAMXYDQ-UHFFFAOYSA-N 474193 3-(1,4-dimethylpiperidin-4-yl)-7- (4-methoxybenzyl)-6- methylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 73::US10912773, Example 73::US11472810, Example 73 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1923 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474193 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474193&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652233 442074390 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217288 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C2CCc3ccc(Cl)cc23)cc1 InChI=1S/C24H22ClN3O2/c1-15-13-28-22(24(29)27(15)14-16-3-8-19(30-2)9-4-16)12-26-23(28)20-10-6-17-5-7-18(25)11-21(17)20/h3-5,7-9,11-13,20H,6,10,14H2,1-2H3 COANVSPOSPBLGF-UHFFFAOYSA-N 474194 3-(6-chloro-2,3-dihydro-1H- inden-1-yl)-7-(4-methoxybenzyl)- 6-methylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 74::US10912773, Example 74::US11472810, Example 74 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 5.00 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474194 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474194&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652306 442074391 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217291 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C2(C)CNC(=O)C2)cc1 InChI=1S/C20H22N4O3/c1-13-10-24-16(9-21-19(24)20(2)8-17(25)22-12-20)18(26)23(13)11-14-4-6-15(27-3)7-5-14/h4-7,9-10H,8,11-12H2,1-3H3,(H,22,25) XKGOGXSNJQICIE-UHFFFAOYSA-N 474195 7-(4-methoxybenzyl)-6-methyl-3- (3-methyl-5-oxopyrrolidin-3- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 75::US10912773, Example 75::US11472810, Example 75 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 236 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474195&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652486 442074392 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217294 COCC(C)(C)c1ncc2n1cc(C)n(Cc1ccc(OC)cc1)c2=O InChI=1S/C20H25N3O3/c1-14-11-23-17(10-21-19(23)20(2,3)13-25-4)18(24)22(14)12-15-6-8-16(26-5)9-7-15/h6-11H,12-13H2,1-5H3 ANGLWHGRWFOZSQ-UHFFFAOYSA-N 474196 3-(1-methoxy-2-methylpropan-2- yl)-7-(4-methoxybenzyl)-6- methylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 76::US10912773, Example 76::US11472810, Example 76 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 122 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474196 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474196&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652293 442074393 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217297 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C(C)C)cc1 InChI=1S/C18H21N3O2/c1-12(2)17-19-9-16-18(22)20(13(3)10-21(16)17)11-14-5-7-15(23-4)8-6-14/h5-10,12H,11H2,1-4H3 RVHZRSIRMVWVKL-UHFFFAOYSA-N 474197 3-isopropyl-7-(4-methoxybenzyl)- 6-methylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 77::US10912773, Example 77::US11472810, Example 77 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 13.0 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474197 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474197&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652354 442074394 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217300 Cc1nc(Cn2c(C)cn3c(ncc3c2=O)C2CCOCC2)cs1 InChI=1S/C17H20N4O2S/c1-11-8-21-15(7-18-16(21)13-3-5-23-6-4-13)17(22)20(11)9-14-10-24-12(2)19-14/h7-8,10,13H,3-6,9H2,1-2H3 SFJUWCCYAPWXBB-UHFFFAOYSA-N 474198 6-methyl-7-((2-methylthiazol-4- yl)methyl)-3-(tetrahydro-2H- pyran-4-yl)imidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 78::US10912773, Example 78::US11472810, Example 78 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1691 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474198 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474198&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652259 442074395 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217303 Cc1cn2c(ncc2c(=O)n1Cc1cscn1)C1CCOCC1 InChI=1S/C16H18N4O2S/c1-11-7-20-14(6-17-15(20)12-2-4-22-5-3-12)16(21)19(11)8-13-9-23-10-18-13/h6-7,9-10,12H,2-5,8H2,1H3 SQDRHBKRJBDLOC-UHFFFAOYSA-N 474200 6-methyl-3-(tetrahydro-2H-pyran- 4-yl)-7-(thiazol-4- ylmethyl)imidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 80::US10912773, Example 80::US11472810, Example 80 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 228 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474200 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474200&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652330 442074397 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217311 Cc1cc(Cn2c(C)cn3c(ncc3c2=O)C2CCOCC2)on1 InChI=1S/C17H20N4O3/c1-11-7-14(24-19-11)10-20-12(2)9-21-15(17(20)22)8-18-16(21)13-3-5-23-6-4-13/h7-9,13H,3-6,10H2,1-2H3 ZKIKXHAKXUODEV-UHFFFAOYSA-N 474203 6-methyl-7-((3-methylisoxazol-5- yl)methyl)-3-(tetrahydro-2H- pyran-4-yl)imidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 83::US10912773, Example 83::US11472810, Example 83 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4444 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474203 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474203&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652332 442074400 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217314 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C2CC(C)OC(C)C2)cc1 InChI=1S/C22H27N3O3/c1-14-12-25-20(11-23-21(25)18-9-15(2)28-16(3)10-18)22(26)24(14)13-17-5-7-19(27-4)8-6-17/h5-8,11-12,15-16,18H,9-10,13H2,1-4H3 IJXXNTVMDPJVBW-UHFFFAOYSA-N 474204 3-(2,6-dimethyltetrahydro-2H- pyran-4-yl)-7-(4-methoxybenzyl)- 6-methylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 84::US10912773, Example 84::US11472810, Example 84 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 627 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474204 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474204&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652545 442074401 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217317 CCCc1ncc2n1cc(C)n(CC1CCCCC1)c2=O InChI=1S/C17H25N3O/c1-3-7-16-18-10-15-17(21)19(13(2)11-20(15)16)12-14-8-5-4-6-9-14/h10-11,14H,3-9,12H2,1-2H3 ZVDAZHCIEJDXMC-UHFFFAOYSA-N 474205 7-(cyclohexylmethyl)-6-methyl-3- propylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 85::US10912773, Example 85::US11472810, Example 85 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 120 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474205 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474205&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652381 442074402 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217320 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C(C)(C)O)cc1 InChI=1S/C18H21N3O3/c1-12-10-21-15(9-19-17(21)18(2,3)23)16(22)20(12)11-13-5-7-14(24-4)8-6-13/h5-10,23H,11H2,1-4H3 RVJAZKLTOAMCHB-UHFFFAOYSA-N 474206 3-(2-hydroxypropan-2-yl)-7-(4- methoxybenzyl)-6- methylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 86::US10912773, Example 86::US11472810, Example 86 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 193 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474206 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474206&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652382 442074403 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217323 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C(C)(C)F)cc1 InChI=1S/C18H20FN3O2/c1-12-10-22-15(9-20-17(22)18(2,3)19)16(23)21(12)11-13-5-7-14(24-4)8-6-13/h5-10H,11H2,1-4H3 DKRDXFRQADAIHU-UHFFFAOYSA-N 474207 3-(2-fluoropropan-2-yl)-7-(4- methoxybenzyl)-6- methylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 87::US10912773, Example 87::US11472810, Example 87 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 108 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474207 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474207&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652496 442074404 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217326 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C2CCNC(=O)CC2)cc1 InChI=1S/C21H24N4O3/c1-14-12-25-18(11-23-20(25)16-5-8-19(26)22-10-9-16)21(27)24(14)13-15-3-6-17(28-2)7-4-15/h3-4,6-7,11-12,16H,5,8-10,13H2,1-2H3,(H,22,26) ZMTDJXQCSYULBW-UHFFFAOYSA-N 474208 7-(4-methoxybenzyl)-6-methyl-3- (7-oxoazepan-4-yl)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 88::US10912773, Example 88::US11472810, Example 88 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 484 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474208&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652312 442074405 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217331 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C(C)c2nc(C)cs2)cc1 InChI=1S/C21H22N4O2S/c1-13-12-28-20(23-13)15(3)19-22-9-18-21(26)24(14(2)10-25(18)19)11-16-5-7-17(27-4)8-6-16/h5-10,12,15H,11H2,1-4H3 XRYJHUBBBIIQDO-UHFFFAOYSA-N 474210 7-(4-methoxybenzyl)-6-methyl-3- (1-(4-methylthiazol-2- yl)ethyl)imidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 90::US10912773, Example 90::US11472810, Example 90 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 34.0 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474210&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652338 442074407 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217334 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C2(C)CCN(C2)S(N)(=O)=O)cc1 InChI=1S/C20H25N5O4S/c1-14-11-25-17(18(26)24(14)12-15-4-6-16(29-3)7-5-15)10-22-19(25)20(2)8-9-23(13-20)30(21,27)28/h4-7,10-11H,8-9,12-13H2,1-3H3,(H2,21,27,28) RZZDUEKLZBHEJJ-UHFFFAOYSA-N 474211 3-(7-(4-methoxybenzyl)-6-methyl- 8-oxo-7,8-dihydroimidazo[1,5- a]pyrazin-3-yl)-3- methylpyrrolidine-1-sulfonamide::US10858362, Example 91::US10912773, Example 91::US11472810, Example 91 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 181 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474211 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474211&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652235 442074408 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217337 COc1ccc(Cn2c(CC3CCCC3)cn3c(ncc3c2=O)C2CCOCC2)cc1 InChI=1S/C25H31N3O3/c1-30-22-8-6-19(7-9-22)16-27-21(14-18-4-2-3-5-18)17-28-23(25(27)29)15-26-24(28)20-10-12-31-13-11-20/h6-9,15,17-18,20H,2-5,10-14,16H2,1H3 TUNXEGCQHJFZRL-UHFFFAOYSA-N 474212 6-(cyclopentylmethyl)-7-(4- methoxybenzyl)-3-(tetrahydro- 2H-pyran-4-yl)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 92::US10912773, Example 92::US11472810, Example 92 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 71.0 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474212 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474212&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652475 442074409 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217340 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)N2CCOCC2)cc1 InChI=1S/C19H22N4O3/c1-14-12-23-17(11-20-19(23)21-7-9-26-10-8-21)18(24)22(14)13-15-3-5-16(25-2)6-4-15/h3-6,11-12H,7-10,13H2,1-2H3 DRHDVSISCJNWFF-UHFFFAOYSA-N 474213 3-(morpholino)-7-(4- methoxybenzyl)-6- methylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 93::US10912773, Example 93::US11472810, Example 93 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 96.0 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474213&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652234 442074410 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217343 COc1ccc(Cn2c(C)cn3c(NC4CCOC4)ncc3c2=O)cc1 InChI=1S/C19H22N4O3/c1-13-10-23-17(9-20-19(23)21-15-7-8-26-12-15)18(24)22(13)11-14-3-5-16(25-2)6-4-14/h3-6,9-10,15H,7-8,11-12H2,1-2H3,(H,20,21) MVGJRDDRTHNROA-UHFFFAOYSA-N 474214 7-(4-methoxybenzyl)-6-methyl-3- ((tetrahydrofuran-3- yl)amino)imidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 94::US10912773, Example 94::US11472810, Example 94 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2516 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474214 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474214&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652491 442074411 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217346 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)N2CCOC[C@H]2C)cc1 InChI=1S/C20H24N4O3/c1-14-11-24-18(10-21-20(24)22-8-9-27-13-15(22)2)19(25)23(14)12-16-4-6-17(26-3)7-5-16/h4-7,10-11,15H,8-9,12-13H2,1-3H3/t15-/m1/s1 VQUWFLFKDYALSX-OAHLLOKOSA-N 474215 (R)-7-(4-methoxybenzyl)-6- methyl-3-(3- methylmorpholino)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 95::US10912773, Example 95::US11472810, Example 95 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 258 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474215 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474215&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652374 442074412 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217349 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)N2CCOC[C@@H]2C)cc1 InChI=1S/C20H24N4O3/c1-14-11-24-18(10-21-20(24)22-8-9-27-13-15(22)2)19(25)23(14)12-16-4-6-17(26-3)7-5-16/h4-7,10-11,15H,8-9,12-13H2,1-3H3/t15-/m0/s1 VQUWFLFKDYALSX-HNNXBMFYSA-N 474216 (S)-7-(4-methoxybenzyl)-6- methyl-3-(3- methylmorpholino)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 96::US10912773, Example 96::US11472810, Example 96 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 48.0 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474216&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652225 442074413 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217352 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)N2CCCOCC2)cc1 InChI=1S/C20H24N4O3/c1-15-13-24-18(12-21-20(24)22-8-3-10-27-11-9-22)19(25)23(15)14-16-4-6-17(26-2)7-5-16/h4-7,12-13H,3,8-11,14H2,1-2H3 VCAGHSXTTDHBAV-UHFFFAOYSA-N 474217 7-(4-methoxybenzyl)-6-methyl-3- (1,4-oxazepan-4-yl)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 97::US10905688, Example 97::US11472810, Example 97 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 202 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474217 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474217&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652220 442074414 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217355 COc1ccc(Cn2c(C)cn3c(ncc3c2=O)N2CCOC(C)(C)C2)cc1 InChI=1S/C21H26N4O3/c1-15-12-25-18(11-22-20(25)23-9-10-28-21(2,3)14-23)19(26)24(15)13-16-5-7-17(27-4)8-6-16/h5-8,11-12H,9-10,13-14H2,1-4H3 HVRCNXOHZPZGSJ-UHFFFAOYSA-N 474218 3-(2,2-dimethylmorpholino)-7-(4- methoxybenzyl)-6- methylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 98::US10905688, Example 98::US11472810, Example 98 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 287 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474218 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474218&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652493 442074415 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217358 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)N1CCC2OCC[C@H]12 InChI=1S/C20H21FN4O2/c1-13-11-25-17(19(26)24(13)12-14-3-2-4-15(21)9-14)10-22-20(25)23-7-5-18-16(23)6-8-27-18/h2-4,9-11,16,18H,5-8,12H2,1H3/t16-,18?/m0/s1 YWWHXMUOPZSUDB-ATNAJCNCSA-N 480884 7-(3-fluorobenzyl)-3-(hexahydro- methylimidazo[1,5-a]pyrazin- 8(7H)-one, isomer 2::US10905688, Example 99, isomer 2::US11472810, Example 99, isomer 1 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 241 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=480884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=480884&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 156595982 443550076 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217363 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)[C@@H]1CCCOC1 InChI=1S/C19H20FN3O2/c1-13-10-23-17(9-21-18(23)15-5-3-7-25-12-15)19(24)22(13)11-14-4-2-6-16(20)8-14/h2,4,6,8-10,15H,3,5,7,11-12H2,1H3/t15-/m1/s1 PZKOOBRKCGIRJF-OAHLLOKOSA-N 474219 7-(3-fluorobenzyl)-6-methyl-3- (tetrahydro-2H-pyran-3- yl)imidazo[1,5-a]pyrazin-8(7H)- one, stereoisomer 1::US10858362, Example 100, isomer 1::US10905688, Example 100, isomer 1::US11472810, Example 100, isomer 1 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 306 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474219 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474219&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652485 442074416 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1217366 Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)[C@H]1CCCOC1 InChI=1S/C19H20FN3O2/c1-13-10-23-17(9-21-18(23)15-5-3-7-25-12-15)19(24)22(13)11-14-4-2-6-16(20)8-14/h2,4,6,8-10,15H,3,5,7,11-12H2,1H3/t15-/m0/s1 PZKOOBRKCGIRJF-HNNXBMFYSA-N 474220 7-(3-fluorobenzyl)-6-methyl-3- (tetrahydro-2H-pyran-3- yl)imidazo[1,5-a]pyrazin-8(7H)- one, stereoisomer 2::US10858362, Example 100, isomer 2::US10905688, Example 100, isomer 2::US11472810, Example 100, isomer 2 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 333 US Patent 10.7270/Q2PG1W0S aid1806918 US11472810 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Juhl, K; Vital, PJ H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474220 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474220&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 122652422 442074417 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1181740 Fc1ccc(cc1)-c1ncc2n1cc(CN1CC(C1)Oc1ccncc1)[nH]c2=O InChI=1S/C21H18FN5O2/c22-15-3-1-14(2-4-15)20-24-9-19-21(28)25-16(11-27(19)20)10-26-12-18(13-26)29-17-5-7-23-8-6-17/h1-9,11,18H,10,12-13H2,(H,25,28) OPPJESMUQLKXLM-UHFFFAOYSA-N 559569 US11370795, Compound (P1)::US11608342, Compound (P1) Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 45090 US Patent 10.7270/Q2W66Q0Q aid1806628 US11370795 Svenstrup, N; Zhang, J; Sun, J; Chen, Y; Kong, J; Ma, R; Zhang, J; Qin, L; Xiao, H; Sun, J; Meng, X; Sun, F; Zhu, J Imara Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=559569 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=559569&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 71550147 471700197 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1181742 O=c1[nH]c(CN2CC(C2)Oc2ccncc2)cn2c(ncc12)-c1ccocc1 559570 US11370795, Compound (P2) Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 5283 US Patent 10.7270/Q2W66Q0Q aid1806628 US11370795 Svenstrup, N; Zhang, J; Sun, J; Chen, Y; Kong, J; Ma, R; Zhang, J; Qin, L; Xiao, H; Sun, J; Meng, X; Sun, F; Zhu, J Imara Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=559570 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=559570&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 165112724 471700198 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1181744 C[C@@H]1CN(Cc2ncccn2)CC1c1cn2c(ncc2c(=O)[nH]1)-c1ccocc1 559571 US11370795, Compound (P3 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 3000 US Patent 10.7270/Q2W66Q0Q aid1806628 US11370795 Svenstrup, N; Zhang, J; Sun, J; Chen, Y; Kong, J; Ma, R; Zhang, J; Qin, L; Xiao, H; Sun, J; Meng, X; Sun, F; Zhu, J Imara Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=559571 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=559571&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 165112726 471700199 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1181746 Fc1ccc(COC2CN(Cc3nn4c(ncc4c(=O)[nH]3)-c3ccocc3)C2)cc1 559572 US11370795, Compound (P4) Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1009 US Patent 10.7270/Q2W66Q0Q aid1806628 US11370795 Svenstrup, N; Zhang, J; Sun, J; Chen, Y; Kong, J; Ma, R; Zhang, J; Qin, L; Xiao, H; Sun, J; Meng, X; Sun, F; Zhu, J Imara Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=559572 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=559572&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 165112728 471700200 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1181748 C[C@@H]1CN(Cc2ncccn2)C[C@H]1c1nc2n(ncc2c(=O)[nH]1)C1CCOCC1 InChI=1S/C20H25N7O2/c1-13-10-26(12-17-21-5-2-6-22-17)11-16(13)18-24-19-15(20(28)25-18)9-23-27(19)14-3-7-29-8-4-14/h2,5-6,9,13-14,16H,3-4,7-8,10-12H2,1H3,(H,24,25,28)/t13-,16-/m1/s1 IWXUVYOOUMLUTQ-CZUORRHYSA-N 50397838 CHEMBL2179105::PF-04447943::US10513524, Reference compound disclosed in WO2008/139293::US11608342, Reference compound disclosed in WO2008/139293 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2500 US Patent 10.7270/Q2W66Q0Q aid1806628 US11370795 Svenstrup, N; Zhang, J; Sun, J; Chen, Y; Kong, J; Ma, R; Zhang, J; Qin, L; Xiao, H; Sun, J; Meng, X; Sun, F; Zhu, J Imara Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397838&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 7RG 25115162 163346862 CHEMBL2179105 ZINC68199983 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223226 CCOc1ncccc1-c1cc(NCc2nnc(C)o2)c2n(nc(C)c2n1)[C@H](C)CC InChI=1S/C22H27N7O2/c1-6-13(3)29-21-18(24-12-19-27-26-15(5)31-19)11-17(25-20(21)14(4)28-29)16-9-8-10-23-22(16)30-7-2/h8-11,13H,6-7,12H2,1-5H3,(H,24,25)/t13-/m1/s1 SJDHGTJKQKPRAR-CYBMUJFWSA-N 580549 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(5-methyl- 1,3,4-oxadiazol-2-yl)methyl]-1-[1- methylpropyl]pyrazolo[4,3-b]pyridin-7-amine, enantiomer 2::US11491140, Example 124 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 9.70 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=580549 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=580549&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 140830718 475726395 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223229 CCOc1ncccc1-c1cc(NCc2cncc(OC)c2)c2n(nc(C)c2n1)[C@H](C)CC InChI=1S/C25H30N6O2/c1-6-16(3)31-24-22(28-14-18-11-19(32-5)15-26-13-18)12-21(29-23(24)17(4)30-31)20-9-8-10-27-25(20)33-7-2/h8-13,15-16H,6-7,14H2,1-5H3,(H,28,29)/t16-/m1/s1 SYWOKLNWWYOPHL-MRXNPFEDSA-N 580550 5-(2-ethoxy-3-pyridyl)-N-[(5-methoxy-3- pyridyl)methyl]-3-methyl-1-[1- methylpropyl]pyrazolo[4,3-b]pyridin-7-amine, enantiomer 2::US11491140, Example 125 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.000 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=580550 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=580550&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 140830731 475726396 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223232 CCOc1ncccc1-c1cc(NCc2ccnc(OC)c2)c2n(nc(C)c2n1)[C@H](C)CC InChI=1S/C25H30N6O2/c1-6-16(3)31-24-21(28-15-18-10-12-26-22(13-18)32-5)14-20(29-23(24)17(4)30-31)19-9-8-11-27-25(19)33-7-2/h8-14,16H,6-7,15H2,1-5H3,(H,28,29)/t16-/m1/s1 JRNBIFGQRNWOKC-MRXNPFEDSA-N 580551 5-(2-ethoxy-3-pyridyl)-N-[(2-methoxy-4- pyridyl)methyl]-3-methyl-1-[1- methylpropyl]pyrazolo[4,3-b]pyridin-7-amine, enantiomer 2::US11491140, Example 126 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 5.40 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=580551 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=580551&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 140830756 475726397 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223235 CCOc1ncccc1-c1cc(NCc2nnn(C)n2)c2n(nc(C)c2n1)[C@@H](C)CC InChI=1S/C21H27N9O/c1-6-13(3)30-20-17(23-12-18-25-28-29(5)27-18)11-16(24-19(20)14(4)26-30)15-9-8-10-22-21(15)31-7-2/h8-11,13H,6-7,12H2,1-5H3,(H,23,24)/t13-/m0/s1 ULBLNKNNIPTFLN-ZDUSSCGKSA-N 580552 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1- methylpropyl]-N-[(2-methyltetrazol-5- yl)methyl]pyrazolo[4,3-b]pyridin-7-amine, enantiomer 2::US11491140, Example 127 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.80 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=580552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=580552&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 140830705 475726398 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223238 CCOc1ncccc1-c1cc(NCc2noc(C)n2)c2n(nc(C)c2n1)[C@@H](C)CC InChI=1S/C22H27N7O2/c1-6-13(3)29-21-18(24-12-19-25-15(5)31-28-19)11-17(26-20(21)14(4)27-29)16-9-8-10-23-22(16)30-7-2/h8-11,13H,6-7,12H2,1-5H3,(H,24,26)/t13-/m0/s1 XOIXJVILDWTHEL-ZDUSSCGKSA-N 580553 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(5-methyl- 1,2,4-oxadiazol-3-yl)methyl]-1-[1- methylpropyl]pyrazolo[4,3-b]pyridin-7-amine, enantiomer 2::US11491140, Example 128 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.20 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=580553 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=580553&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 140830723 475726399 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223241 CCOc1ncccc1-c1cc(NCc2coc(C)n2)c2n(nc(C)c2n1)[C@H](C)CC InChI=1S/C23H28N6O2/c1-6-14(3)29-22-20(25-12-17-13-31-16(5)26-17)11-19(27-21(22)15(4)28-29)18-9-8-10-24-23(18)30-7-2/h8-11,13-14H,6-7,12H2,1-5H3,(H,25,27)/t14-/m1/s1 NAPUFLNYEBBQPU-CQSZACIVSA-N 580554 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(2- methyloxazol-4-yl)methyl]-1-[1- methylpropyl]pyrazolo[4,3-b]pyridin-7-amine, enantiomer 2::US11491140, Example 129 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 11.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=580554 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=580554&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 140830768 475726400 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223244 CCOc1ncccc1-c1cc(NCc2c[nH]cn2)c2n(nc(C)c2n1)[C@H](C)CC 580555 5-(2-ethoxy-3-pyridyl)-N-(1H-imidazol-4- ylmethyl)-3-methyl-1-[1- methylpropyl]pyrazolo[4,3-b]pyridin-7-amine, enantiomer 2::US11491140, Example 130 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 11.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=580555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=580555&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 140830764 475726401 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223247 CCOc1ncccc1-c1cc(NCc2cc(C)[nH]n2)c2n(nc(C)c2n1)[C@@H](C)CC 580556 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1- methylpropyl]-N-[(5-methyl-1H-pyrazol-3- yl)methyl]pyrazolo[4,3-b]pyridin-7-amine, enantiomer 2::US11491140, Example 131 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.350 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=580556 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=580556&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 140830724 475726402 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223250 CCOc1ncccc1-c1cc(NCc2cn(C)cn2)c2n(nc(C)c2n1)[C@@H](C)CC InChI=1S/C23H29N7O/c1-6-15(3)30-22-20(25-12-17-13-29(5)14-26-17)11-19(27-21(22)16(4)28-30)18-9-8-10-24-23(18)31-7-2/h8-11,13-15H,6-7,12H2,1-5H3,(H,25,27)/t15-/m0/s1 NIXYLBKMUOTNON-HNNXBMFYSA-N 580557 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(1- methylimidazol-4-yl)methyl]-1-[1- methylpropyl]pyrazolo[4,3-b]pyridin-7-amine, enantiomer 2::US11491140, Example 132 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.140 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=580557 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=580557&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 140830753 475726403 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223253 CCOc1ncccc1-c1cc(NCc2cnc(C)o2)c2n(nc(C)c2n1)[C@H](C)CC InChI=1S/C23H28N6O2/c1-6-14(3)29-22-20(26-13-17-12-25-16(5)31-17)11-19(27-21(22)15(4)28-29)18-9-8-10-24-23(18)30-7-2/h8-12,14H,6-7,13H2,1-5H3,(H,26,27)/t14-/m1/s1 ZJGPWXQIKUCOGR-CQSZACIVSA-N 580558 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(2- methyloxazol-5-yl)methyl]-1-[1- methylpropyl]pyrazolo[4,3-b]pyridin-7-amine, enantiomer 2::US11491140, Example 133 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 11.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=580558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=580558&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 140830755 475726404 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223256 CCCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C23H30N8O/c1-6-11-32-23-17(9-8-10-24-23)18-12-19(25-13-20-26-14-30(5)29-20)22-21(27-18)16(4)28-31(22)15(3)7-2/h8-10,12,14-15H,6-7,11,13H2,1-5H3,(H,25,27) SXNFSKBWTTYFLI-UHFFFAOYSA-N 279103 3-methyl-1-[1-methylpropyl]-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]-5-(2-propoxy-3-pyridyl)pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 134::US10512632, Example 134::US10766893, Example S134::US10806718, Example 134::US11491140, Example 134::US11634416, Example 134 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.960 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279103&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273429 378160688 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223259 CCCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(nc(C)c2n1)C(C)CC 279104 3-methyl-1-[1-methylpropyl]-5-(2-propoxy-3-pyridyl)-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 135::US10512632, Example 135::US10766893, Example S135::US10806718, Example 135::US11491140, Example 135::US11634416, Example 135 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.90 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279104&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273430 378160689 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223262 CCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(ncc2n1)C(C)CC 279105 5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine, enantiomer 1::US10034861, Example 136::US10034861, Example 137::US10512632, Example 137::US10766893, Example S137::US10806718, Example 137::US11026923, Example 137::US11491140, Example 137::US11634416, Example 137 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 62.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279105&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273431 378160690 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223265 CCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(ncc2n1)C(C)CC 279105 5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine, enantiomer 1::US10034861, Example 136::US10034861, Example 137::US10512632, Example 137::US10766893, Example S137::US10806718, Example 137::US11026923, Example 137::US11491140, Example 137::US11634416, Example 137 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 180 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279105&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273431 378160690 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223268 CCOc1ncccc1-c1cc(NCc2nnc(C)o2)c2n(ncc2n1)C(C)CC InChI=1S/C21H25N7O2/c1-5-13(3)28-20-17(23-12-19-27-26-14(4)30-19)10-16(25-18(20)11-24-28)15-8-7-9-22-21(15)29-6-2/h7-11,13H,5-6,12H2,1-4H3,(H,23,25) BIQGCKNODPBTSC-UHFFFAOYSA-N 279107 5-(2-ethoxy-3-pyridyl)-N-[(5-methyl-1,3,4-oxadiazol-2-yl)methyl]-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 138::US10034861, Example 139::US10512632, Example 139::US10766893, Example S139::US10806718, Example 139::US11026923, Example 139::US11491140, Example 139::US11634416, Example 139 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 93.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279107&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273432 378160691 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223271 CCOc1ncccc1-c1cc(NCc2nnc(C)o2)c2n(ncc2n1)C(C)CC InChI=1S/C21H25N7O2/c1-5-13(3)28-20-17(23-12-19-27-26-14(4)30-19)10-16(25-18(20)11-24-28)15-8-7-9-22-21(15)29-6-2/h7-11,13H,5-6,12H2,1-4H3,(H,23,25) BIQGCKNODPBTSC-UHFFFAOYSA-N 279107 5-(2-ethoxy-3-pyridyl)-N-[(5-methyl-1,3,4-oxadiazol-2-yl)methyl]-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 138::US10034861, Example 139::US10512632, Example 139::US10766893, Example S139::US10806718, Example 139::US11026923, Example 139::US11491140, Example 139::US11634416, Example 139 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 330 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279107&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273432 378160691 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223274 CCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(ncc2n1)C(C)CC InChI=1S/C21H26N8O/c1-5-14(3)29-20-17(23-12-19-24-13-28(4)27-19)10-16(26-18(20)11-25-29)15-8-7-9-22-21(15)30-6-2/h7-11,13-14H,5-6,12H2,1-4H3,(H,23,26) OKQUCPHNAVGTKM-UHFFFAOYSA-N 279109 5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 140::US10034861, Example 141::US10512632, Example 141::US10766893, Example S141::US10806718, Example 141::US11026923, Example 141::US11491140, Example 141::US11634416, Example 141 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 32.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279109&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273433 378160692 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223277 CCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(ncc2n1)C(C)CC InChI=1S/C21H26N8O/c1-5-14(3)29-20-17(23-12-19-24-13-28(4)27-19)10-16(26-18(20)11-25-29)15-8-7-9-22-21(15)30-6-2/h7-11,13-14H,5-6,12H2,1-4H3,(H,23,26) OKQUCPHNAVGTKM-UHFFFAOYSA-N 279109 5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 140::US10034861, Example 141::US10512632, Example 141::US10766893, Example S141::US10806718, Example 141::US11026923, Example 141::US11491140, Example 141::US11634416, Example 141 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 44.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279109&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273433 378160692 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223280 CCCOc1ncccc1-c1cc(NCc2cn(C)cn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H29N7O/c1-6-10-31-23-18(8-7-9-24-23)19-11-20(25-12-17-13-29(5)14-26-17)22-21(27-19)16(4)28-30(22)15(2)3/h7-9,11,13-15H,6,10,12H2,1-5H3,(H,25,27) KLLVPOPJMWWQFO-UHFFFAOYSA-N 279111 1-isopropyl-3-methyl-N-[(1-methylimidazol-4-yl)methyl]-5-(2-propoxy-3-pyridyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 142::US10512632, Example 142::US10766893, Example S142::US10806718, Example 142::US11491140, Example 142::US11634416, Example 142 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.260 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279111&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273434 378160693 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223283 CCCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H27N7O/c1-5-11-30-22-17(7-6-9-23-22)18-12-19(24-13-16-8-10-25-27-16)21-20(26-18)15(4)28-29(21)14(2)3/h6-10,12,14H,5,11,13H2,1-4H3,(H,24,26)(H,25,27) WVFCCHYAETYKIF-UHFFFAOYSA-N 279112 1-isopropyl-3-methyl-5-(2-propoxy-3-pyridyl)-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 143::US10512632, Example 143::US10766893, Example S143::US10806718, Example 143::US11026923, Example 143::US11491140, Example 143::US11634416, Example 143 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 3.80 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279112&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273435 378160694 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223286 CCOc1ncccc1-c1cc(NCc2nc[nH]n2)c2n(nc(C)c2n1)C(C)CC 279113 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]-N-(1H-1,2,4-triazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 144::US10512632, Example 144::US10766893, Example S144::US10806718, Example 144::US11026923, Example 144::US11491140, Example 144::US11634416, Example 144 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 14.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279113&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273438 378160695 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223289 CCCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H28N8O/c1-6-10-31-22-16(8-7-9-23-22)17-11-18(24-12-19-25-13-29(5)28-19)21-20(26-17)15(4)27-30(21)14(2)3/h7-9,11,13-14H,6,10,12H2,1-5H3,(H,24,26) ROWMNTAKQCZGNZ-UHFFFAOYSA-N 279114 1-isopropyl-3-methyl-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]-5-(2-propoxy-3-pyridyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 145::US10512632, Example 145::US10766893, Example S145::US10806718, Example 145::US11026923, Example 145::US11491140, Example 145::US11634416, Example 145 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.410 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279114&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273436 378160696 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223292 CCCOc1ncccc1-c1cc(NCc2nc[nH]n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-5-9-30-21-15(7-6-8-22-21)16-10-17(23-11-18-24-12-25-27-18)20-19(26-16)14(4)28-29(20)13(2)3/h6-8,10,12-13H,5,9,11H2,1-4H3,(H,23,26)(H,24,25,27) RLGQIPCFRYRCDL-UHFFFAOYSA-N 279115 1-isopropyl-3-methyl-5-(2-propoxy-3-pyridyl)-N-(1H-1,2,4-triazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 146::US10512632, Example 146::US10766893, Example S146::US10806718, Example 146::US11026923, Example 146::US11491140, Example 146::US11634416, Example 146 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 3.90 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279115&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273440 378160697 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223295 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1nccs1 InChI=1S/C18H21N7S/c1-11(2)25-17-14(20-8-13-9-21-24(4)10-13)7-15(18-19-5-6-26-18)22-16(17)12(3)23-25/h5-7,9-11H,8H2,1-4H3,(H,20,22) TVGMRVMYCDHOEG-UHFFFAOYSA-N 279116 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-thiazol-2-yl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 147::US10512632, Example 147::US10618913, Example S147::US10766893, Example S147::US10806718, Example 147::US11026923, Example 147::US11491140, Example 147::US11634416, Example 147 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 12.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279116&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273437 378160698 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223298 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1ncc(C)s1 InChI=1S/C19H23N7S/c1-11(2)26-18-15(20-8-14-9-22-25(5)10-14)6-16(19-21-7-12(3)27-19)23-17(18)13(4)24-26/h6-7,9-11H,8H2,1-5H3,(H,20,23) ACZBEPYVSHJPFB-UHFFFAOYSA-N 279117 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-(5-methylthiazol-2-yl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 148::US10512632, Example 148::US10766893, Example S148::US10806718, Example 148::US11026923, Example 148::US11491140, Example 148::US11634416, Example 148 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 110 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279117&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273439 378160699 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223301 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1nc(C)cs1 InChI=1S/C19H23N7S/c1-11(2)26-18-15(20-7-14-8-21-25(5)9-14)6-16(19-22-12(3)10-27-19)23-17(18)13(4)24-26/h6,8-11H,7H2,1-5H3,(H,20,23) HCLONMUJAHJFIH-UHFFFAOYSA-N 279118 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-(4-methylthiazol-2-yl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 149::US10512632, Example 149::US10766893, Example S149::US10806718, Example 149::US11026923, Example 149::US11491140, Example 149::US11634416, Example 149 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 29.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279118&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273441 378160700 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223304 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)N1CC(C)OC1=O InChI=1S/C19H25N7O2/c1-11(2)26-18-15(20-7-14-8-21-24(5)10-14)6-16(22-17(18)13(4)23-26)25-9-12(3)28-19(25)27/h6,8,10-12H,7,9H2,1-5H3,(H,20,22) YBJPEIIVVVNBPC-UHFFFAOYSA-N 279119 3-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]-5-methyl-oxazolidin-2-one::US10034861, Example 150::US10512632, Example 150::US10766893, Example S150::US10806718, Example 150::US11026923, Example 150::US11491140, Example 150::US11634416, Example 150 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 44.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279119&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273442 378160701 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223307 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)N1CCOC1=O InChI=1S/C18H23N7O2/c1-11(2)25-17-14(19-8-13-9-20-23(4)10-13)7-15(21-16(17)12(3)22-25)24-5-6-27-18(24)26/h7,9-11H,5-6,8H2,1-4H3,(H,19,21) CBOOBJUJEUVRPS-UHFFFAOYSA-N 279120 3-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]oxazolidin-2-one::US10034861, Example 151::US10512632, Example 151::US10766893, Example S151::US10806718, Example 151::US11026923, Example 151::US11491140, Example 151::US11634416, Example 151 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 10.00 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279120&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273443 378160702 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223310 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)N1CCC1=O InChI=1S/C18H23N7O/c1-11(2)25-18-14(19-8-13-9-20-23(4)10-13)7-15(24-6-5-16(24)26)21-17(18)12(3)22-25/h7,9-11H,5-6,8H2,1-4H3,(H,19,21) SLJWZSCTWDVJBR-UHFFFAOYSA-N 279121 1-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]azetidin-2-one::US10034861, Example 152::US10512632, Example 152::US10766893, Example S152::US10806718, Example 152::US11026923, Example 152::US11491140, Example 152::US11634416, Example 152 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 48.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279121&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273444 378160703 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223313 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)N1CCN(C1=O)C(C)(C)C InChI=1S/C22H32N8O/c1-14(2)30-20-17(23-11-16-12-24-27(7)13-16)10-18(25-19(20)15(3)26-30)28-8-9-29(21(28)31)22(4,5)6/h10,12-14H,8-9,11H2,1-7H3,(H,23,25) KIFHGJKUXDTDBI-UHFFFAOYSA-N 279122 1-tert-butyl-3-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]imidazolidin-2-one::US10034861, Example 153::US10512632, Example 153::US10766893, Example S153::US10806718, Example 153::US11026923, Example 153::US11491140, Example 153::US11634416, Example 153 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 130 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279122&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273445 378160704 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223316 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)N1CCCC1=O InChI=1S/C19H25N7O/c1-12(2)26-19-15(20-9-14-10-21-24(4)11-14)8-16(22-18(19)13(3)23-26)25-7-5-6-17(25)27/h8,10-12H,5-7,9H2,1-4H3,(H,20,22) CXGJWWJDXYZFFZ-UHFFFAOYSA-N 279123 1-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]pyrrolidin-2-one::US10034861, Example 154::US10512632, Example 154::US10766893, Example S154::US10806718, Example 154::US11026923, Example 154::US11491140, Example 154::US11634416, Example 154 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 26.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279123&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273446 378160705 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223319 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)N1C(C)COC1=O InChI=1S/C19H25N7O2/c1-11(2)26-18-15(20-7-14-8-21-24(5)9-14)6-16(22-17(18)13(4)23-26)25-12(3)10-28-19(25)27/h6,8-9,11-12H,7,10H2,1-5H3,(H,20,22) DXKZTPARVQEQMA-UHFFFAOYSA-N 279124 3-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]-4-methyl-oxazolidin-2-one::US10034861, Example 155::US10512632, Example 155::US10766893, Example S155::US10806718, Example 155::US11026923, Example 155::US11491140, Example 155::US11634416, Example 155 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.20 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279124&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273447 378160706 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223322 CCC1COC(=O)N1c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C20H27N7O2/c1-6-15-11-29-20(28)26(15)17-7-16(21-8-14-9-22-25(5)10-14)19-18(23-17)13(4)24-27(19)12(2)3/h7,9-10,12,15H,6,8,11H2,1-5H3,(H,21,23) CVOILQIVJFYVAQ-UHFFFAOYSA-N 279125 4-ethyl-3-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]oxazolidin-2-one::US10034861, Example 156::US10512632, Example 156::US10766893, Example S156::US10806718, Example 156::US11026923, Example 156::US11491140, Example 156::US11634416, Example 156 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 31.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279125&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273448 378160707 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223325 CCOc1ncccc1-c1cc(CNc2cncc(OC)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-20(8-7-9-26-24)21-10-17(12-27-18-11-19(31-5)14-25-13-18)23-22(28-21)16(4)29-30(23)15(2)3/h7-11,13-15,27H,6,12H2,1-5H3 BXZMPJVMGAVKJS-UHFFFAOYSA-N 279126 N-[[5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-yl]methyl]-5-methoxy-pyridin-3-amine::US10034861, Example 157::US10512632, Example 157::US10766893, Example S157::US10806718, Example 157::US11026923, Example 157::US11491140, Example 157::US11634416, Example 157 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 34.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279126&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273449 378160708 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223328 CCOc1ncccc1-c1cc(CNc2ncn(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-6-30-20-16(8-7-9-22-20)17-10-15(11-23-21-24-12-28(5)27-21)19-18(25-17)14(4)26-29(19)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,23,27) XUAILHHYTLESDG-UHFFFAOYSA-N 279127 N-[[5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-yl]methyl]-1-methyl-1,2,4-triazol-3-amine::US10034861, Example 158::US10512632, Example 158::US10766893, Example S158::US10806718, Example 158::US11026923, Example 158::US11491140, Example 158::US11634416, Example 158 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 23.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279127&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273450 378160709 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223331 CCOc1ncccc1-c1cc(CCc2cncc(OC)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C25H29N5O2/c1-6-32-25-21(8-7-11-27-25)22-13-19(10-9-18-12-20(31-5)15-26-14-18)24-23(28-22)17(4)29-30(24)16(2)3/h7-8,11-16H,6,9-10H2,1-5H3 KRADQTILGMSJGT-UHFFFAOYSA-N 279128 5-(2-ethoxy-3-pyridyl)-1-isopropyl-7-[2-(5-methoxy-3-pyridyl)ethyl]-3-methyl-pyrazolo[4,3-b]pyridine::US10034861, Example 159::US10512632, Example 159::US10766893, Example S159::US10806718, Example 159::US11026923, Example 159::US11491140, Example 159::US11634416, Example 159 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 270 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279128&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273451 378160710 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223334 CCOc1ncccc1-c1cc(CCc2ncn(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H27N7O/c1-6-30-22-17(8-7-11-23-22)18-12-16(9-10-19-24-13-28(5)27-19)21-20(25-18)15(4)26-29(21)14(2)3/h7-8,11-14H,6,9-10H2,1-5H3 DQKKFAGODSQYOO-UHFFFAOYSA-N 279129 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-7-[2-(1-methyl-1,2,4-triazol-3-yl)ethyl]pyrazolo[4,3-b]pyridine::US10034861, Example 160::US10512632, Example 160::US10766893, Example S160::US10806718, Example 160::US11026923, Example 160::US11491140, Example 160::US11634416, Example 160 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 23.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279129&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273452 378160711 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223337 CCOc1ncccc1-c1cc(NCc2ncnn2C)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-6-30-21-15(8-7-9-22-21)16-10-17(23-11-18-24-12-25-28(18)5)20-19(26-16)14(4)27-29(20)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,23,26) DSJWNAKWTOCISO-UHFFFAOYSA-N 425070 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methyl-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10512632, Example 161::US10618913, Example S161::US10766893, Example S161::US10806718, Example 161::US11026923, Example 161::US11491140, Example 162::US11634416, Example 161 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 60.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=425070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=425070&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138536279 434150493 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223340 CCOc1ncccc1-c1cc(NCc2ncnn2C)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-6-30-21-15(8-7-9-22-21)16-10-17(23-11-18-24-12-25-28(18)5)20-19(26-16)14(4)27-29(20)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,23,26) DSJWNAKWTOCISO-UHFFFAOYSA-N 425070 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methyl-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10512632, Example 161::US10618913, Example S161::US10766893, Example S161::US10806718, Example 161::US11026923, Example 161::US11491140, Example 162::US11634416, Example 161 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 100.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=425070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=425070&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138536279 434150493 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223343 CCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(nc(C)c2n1)C1COC1 InChI=1S/C21H24N8O2/c1-4-31-21-15(6-5-7-22-21)16-8-17(23-9-18-24-12-28(3)27-18)20-19(25-16)13(2)26-29(20)14-10-30-11-14/h5-8,12,14H,4,9-11H2,1-3H3,(H,23,25) KHCSAUOHEOUDEI-UHFFFAOYSA-N 279132 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]-1-(oxetan-3-yl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 163::US10512632, Example 163::US10618913, Example S163::US10766893, Example S163::US10806718, Example 163::US11026923, Example 163::US11491140, Example 163::US11634416, Example 163 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 120 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279132&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273457 378160713 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223346 CCOc1ncccc1-c1cc(SCCC(=O)OCC(C)C)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H32N4O3S/c1-7-30-24-18(9-8-11-25-24)19-13-20(32-12-10-21(29)31-14-15(2)3)23-22(26-19)17(6)27-28(23)16(4)5/h8-9,11,13,15-16H,7,10,12,14H2,1-6H3 HVDCJFCTBUPVCE-UHFFFAOYSA-N 279133 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylsulfanyl]pyrazolo[4,3-b]pyridine::US10034861, Example 164::US10806718, Example 164::US11026923, Example 164::US11491140, Example 164::US11634416, Example 164 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 6.80 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279133&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273278 378160714 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223349 CCOc1ncccc1-c1cc(N(Cc2cnn(c2)C(F)F)Cc2ccc(OC)cc2)c2n(nc(C)c2n1)C(C)C InChI=1S/C30H33F2N7O2/c1-6-41-29-24(8-7-13-33-29)25-14-26(28-27(35-25)20(4)36-39(28)19(2)3)37(16-21-9-11-23(40-5)12-10-21)17-22-15-34-38(18-22)30(31)32/h7-15,18-19,30H,6,16-17H2,1-5H3 UXTFTMXAFOTATJ-UHFFFAOYSA-N 279134 N-[[1-(difluoromethyl)pyrazol-4-yl]methyl]-5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 165::US10512632, Example 165::US10618913, Example S165::US11026923, Example 165::US11491140, Example 165::US11634416, Example 165 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 73.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279134&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273284 378160715 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223352 CCOc1ncccc1-c1cc(NCc2cc(CF)on2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H25FN6O2/c1-5-30-22-17(7-6-8-24-22)18-10-19(25-12-15-9-16(11-23)31-28-15)21-20(26-18)14(4)27-29(21)13(2)3/h6-10,13H,5,11-12H2,1-4H3,(H,25,26) XUHFADCPGYKQAR-UHFFFAOYSA-N 279135 5-(2-ethoxy-3-pyridyl)-N-[[5-(fluoromethyl)isoxazol-3-yl]methyl]-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::BDBM425076::US10034861, Example 166::US10512632, Example 166::US10766893, Example S166::US10806718, Example 166::US11026923, Example 166::US11491140, Example 166::US11634416, Example 166 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.10 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279135&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273459 378160716 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223355 CCOc1ncccc1-c1cc(NCc2cc(CF)no2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H25FN6O2/c1-5-30-22-17(7-6-8-24-22)18-10-19(25-12-16-9-15(11-23)28-31-16)21-20(26-18)14(4)27-29(21)13(2)3/h6-10,13H,5,11-12H2,1-4H3,(H,25,26) VTULNMARMGUDCN-UHFFFAOYSA-N 279136 5-(2-ethoxy-3-pyridyl)-N-[[3-(fluoromethyl)isoxazol-5-yl]methyl]-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 167::US10766893, Example S167::US10806718, Example 167::US11026923, Example 167::US11491140, Example 167::US11634416, Example 167 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 11.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279136&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273460 378160717 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223358 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1ncco1 InChI=1S/C18H21N7O/c1-11(2)25-17-14(20-8-13-9-21-24(4)10-13)7-15(18-19-5-6-26-18)22-16(17)12(3)23-25/h5-7,9-11H,8H2,1-4H3,(H,20,22) IMKYKBMLZRNQRQ-UHFFFAOYSA-N 279137 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-oxazol-2-yl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 168::US10512632, Example 168::US10618913, Example S168::US10766893, Example S168::US10806718, Example 168::US11026923, Example 168::US11491140, Example 168::US11634416, Example 168 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 14.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279137&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273461 378160718 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223361 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1cnnn1C InChI=1S/C18H23N9/c1-11(2)27-18-15(19-7-13-8-21-25(4)10-13)6-14(16-9-20-24-26(16)5)22-17(18)12(3)23-27/h6,8-11H,7H2,1-5H3,(H,19,22) YPYKZBZKFWCVCN-UHFFFAOYSA-N 279138 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-(3-methyltriazol-4-yl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 169::US10512632, Example 169::US10618913, Example S169::US10766893, Example S169::US10806718, Example 169::US11026923, Example 169::US11491140, Example 169::US11634416, Example 169 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 610 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279138&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273462 378160719 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223364 COc1ncccc1-c1cc(NCc2cccnc2C(F)(F)F)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H23F3N6O/c1-13(2)32-20-18(29-12-15-7-5-9-27-21(15)23(24,25)26)11-17(30-19(20)14(3)31-32)16-8-6-10-28-22(16)33-4/h5-11,13H,12H2,1-4H3,(H,29,30) GLFDPBHOMZCMEF-UHFFFAOYSA-N 279139 1-isopropyl-5-(2-methoxy-3-pyridyl)-3-methyl-N-[[2-(trifluoromethyl)-3-pyridyl]methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 170::US10512632, Example 170::US10766893, Example S170::US10806718, Example 170::US11026923, Example 170::US11491140, Example 170::US11634416, Example 170 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 42.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279139&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273463 378160720 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223367 COc1ncccc1CNc1cc(nc2c(C)nn(C(C)C)c12)-c1ccc[nH]c1=O InChI=1S/C22H24N6O2/c1-13(2)28-20-18(25-12-15-7-5-10-24-22(15)30-4)11-17(26-19(20)14(3)27-28)16-8-6-9-23-21(16)29/h5-11,13H,12H2,1-4H3,(H,23,29)(H,25,26) YJCZMNIYQABZMT-UHFFFAOYSA-N 279140 3-[1-isopropyl-7-[(2-methoxy-3-pyridyl)methylamino]-3-methyl-pyrazolo[4,3-b]pyridin-5-yl]-1H-pyridin-2-one::US10034861, Example 171::US10512632, Example 171::US10766893, Example S171::US10806718, Example 171::US11026923, Example 171::US11491140, Example 171::US11634416, Example 171 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 290 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279140 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279140&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 136214892 378160721 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223370 CCOc1ncccc1-c1cc(NCc2ccncc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(8-7-10-26-24)19-12-20(27-13-17-9-11-25-14-21(17)31-5)23-22(28-19)16(4)29-30(23)15(2)3/h7-12,14-15H,6,13H2,1-5H3,(H,27,28) ZDNREOIUOKDWKN-UHFFFAOYSA-N 425081 US10512632, Example 172::US10766893, Example S172::US10806718, Example 172::US11026923, Example 172::US11491140, Example 172::US11634416, Example 172 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 40.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=425081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=425081&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138535948 434150496 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223373 COc1ncccc1-c1cc(NCc2cnc(C)s2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H24N6OS/c1-12(2)27-20-18(24-11-15-10-23-14(4)29-15)9-17(25-19(20)13(3)26-27)16-7-6-8-22-21(16)28-5/h6-10,12H,11H2,1-5H3,(H,24,25) SVOMGFJYTSFSPH-UHFFFAOYSA-N 279142 1-isopropyl-5-(2-methoxy-3-pyridyl)-3-methyl-N-[(2-methylthiazol-5-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 173::US10512632, Example 173::US10766893, Example S173::US11026923, Example 173::US11491140, Example 173::US11634416, Example 173 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 49.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279142&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273465 378160722 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223376 COc1ncccc1CNc1cc(nc2c(C)nn(C(C)C)c12)-c1cccnc1OC1CC1 InChI=1S/C25H28N6O2/c1-15(2)31-23-21(28-14-17-7-5-11-26-24(17)32-4)13-20(29-22(23)16(3)30-31)19-8-6-12-27-25(19)33-18-9-10-18/h5-8,11-13,15,18H,9-10,14H2,1-4H3,(H,28,29) QLFKDVQWAWXRKU-UHFFFAOYSA-N 279143 5-(2-cyclopropoxypyridin-3-yl)-1-isopropyl-N-((2-methoxypyridin-3-yl)methyl)-3-methyl-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 174::US10512632, Example 174::US10766893, Example S174::US10806718, Example 174::US11026923, Example 174::US11491140, Example 174::US11634416, Example 174 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 18.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279143 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279143&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273466 378160723 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223379 COc1ncccc1CNc1cc(nc2c(C)nn(C(C)C)c12)-c1ccnn1C InChI=1S/C21H25N7O/c1-13(2)28-20-17(23-12-15-7-6-9-22-21(15)29-5)11-16(18-8-10-24-27(18)4)25-19(20)14(3)26-28/h6-11,13H,12H2,1-5H3,(H,23,25) CROUXODBTXNMIZ-UHFFFAOYSA-N 279144 1-isopropyl-N-((2-methoxypyridin-3-yl)methyl)-3-methyl-5-(1-methyl-1H-pyrazol-5-yl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 175::US10512632, Example 175::US10766893, Example S175::US10806718, Example 175::US11026923, Example 175::US11491140, Example 175::US11634416, Example 175 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 83.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279144&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273467 378160724 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223382 CCOc1ncccc1-c1cc(NCc2ncc(OC)cn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O2/c1-6-32-23-17(8-7-9-24-23)18-10-19(25-13-20-26-11-16(31-5)12-27-20)22-21(28-18)15(4)29-30(22)14(2)3/h7-12,14H,6,13H2,1-5H3,(H,25,28) NLZDQEYNQWGPGP-UHFFFAOYSA-N 279145 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(5-methoxypyrimidin-2-yl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 176::US10512632, Example 176::US10766893, Example S176::US10806718, Example 176::US11026923, Example 176::US11491140, Example 176::US11634416, Example 176 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 81.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279145&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273468 378160725 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223385 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1ccc[nH]c1=O InChI=1S/C20H23N7O/c1-12(2)27-19-17(22-9-14-10-23-26(4)11-14)8-16(24-18(19)13(3)25-27)15-6-5-7-21-20(15)28/h5-8,10-12H,9H2,1-4H3,(H,21,28)(H,22,24) ZZXWQIDOSVIHIM-UHFFFAOYSA-N 279146 3-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]-1H-pyridin-2-one::US10034861, Example 177::US10512632, Example 177::US10766893, Example S177::US10806718, Example 177::US11026923, Example 177::US11491140, Example 177::US11634416, Example 177 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 130 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279146&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 136214893 378160726 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223388 CCOc1ncccc1-c1cc(NCc2cccnc2C(F)F)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H26F2N6O/c1-5-33-24-17(9-7-11-28-24)18-12-19(22-20(30-18)15(4)31-32(22)14(2)3)29-13-16-8-6-10-27-21(16)23(25)26/h6-12,14,23H,5,13H2,1-4H3,(H,29,30) IRSHUSVLDQPATB-UHFFFAOYSA-N 279147 N-[[2-(difluoromethyl)-3-pyridyl]methyl]-5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 178::US10512632, Example 178::US10766893, Example S178::US10806718, Example 178::US11026923, Example 178::US11491140, Example 178::US11634416, Example 178 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 31.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279147&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273469 378160727 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223391 CCOc1ncccc1-c1cc(NCc2cc(OC)ncn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O2/c1-6-32-23-17(8-7-9-24-23)18-11-19(25-12-16-10-20(31-5)27-13-26-16)22-21(28-18)15(4)29-30(22)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,25,28) RTCQCKBUFIYEDZ-UHFFFAOYSA-N 279148 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(6-methoxypyrimidin-4-yl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 179::US10512632, Example 179::US10766893, Example S179::US10806718, Example 179::US11026923, Example 179::US11491140, Example 179::US11634416, Example 179 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.80 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279148&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273471 378160728 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223394 CCOC(=N)C(=C/C=C)\c1cc(NCc2cccnc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H30N6O2/c1-7-10-18(23(25)32-8-2)19-13-20(27-14-17-11-9-12-26-24(17)31-6)22-21(28-19)16(5)29-30(22)15(3)4/h7,9-13,15,25H,1,8,14H2,2-6H3,(H,27,28)/b18-10-,25-23? XJADPOFFELMXTA-LBYCDZEQSA-N 580605 5-(2-(ethoxy-1,1-d2)pyridin-3-yl)-1-isopropyl- N((2-methoxypyridin-3-yl)methyl)-3-methyl- 1H-pyrazolo[4,3-b]pyridin-7-amine::US11491140, Example 180::US11491140, Example 181::US11491140, Example 182 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 27.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=580605 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=580605&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 166594432 475726451 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223397 CCOC(=N)C(=C/C=C)\c1cc(NCc2cccnc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H30N6O2/c1-7-10-18(23(25)32-8-2)19-13-20(27-14-17-11-9-12-26-24(17)31-6)22-21(28-19)16(5)29-30(22)15(3)4/h7,9-13,15,25H,1,8,14H2,2-6H3,(H,27,28)/b18-10-,25-23? XJADPOFFELMXTA-LBYCDZEQSA-N 580605 5-(2-(ethoxy-1,1-d2)pyridin-3-yl)-1-isopropyl- N((2-methoxypyridin-3-yl)methyl)-3-methyl- 1H-pyrazolo[4,3-b]pyridin-7-amine::US11491140, Example 180::US11491140, Example 181::US11491140, Example 182 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 31.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=580605 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=580605&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 166594432 475726451 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223400 CCOC(=N)C(=C/C=C)\c1cc(NCc2cccnc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H30N6O2/c1-7-10-18(23(25)32-8-2)19-13-20(27-14-17-11-9-12-26-24(17)31-6)22-21(28-19)16(5)29-30(22)15(3)4/h7,9-13,15,25H,1,8,14H2,2-6H3,(H,27,28)/b18-10-,25-23? XJADPOFFELMXTA-LBYCDZEQSA-N 580605 5-(2-(ethoxy-1,1-d2)pyridin-3-yl)-1-isopropyl- N((2-methoxypyridin-3-yl)methyl)-3-methyl- 1H-pyrazolo[4,3-b]pyridin-7-amine::US11491140, Example 180::US11491140, Example 181::US11491140, Example 182 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 24.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=580605 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=580605&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 166594432 475726451 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223403 COc1ncccc1CNc1cc(nc2c(C)nn(C(C)C)c12)C(=C\C=C)\C(=N)C(F)(F)F InChI=1S/C23H25F3N6O/c1-6-8-16(21(27)23(24,25)26)17-11-18(29-12-15-9-7-10-28-22(15)33-5)20-19(30-17)14(4)31-32(20)13(2)3/h6-11,13,27H,1,12H2,2-5H3,(H,29,30)/b16-8-,27-21? OJTUUGACOKQJNT-QHMQWLFDSA-N 501554 1-isopropyl-N-((2-methoxypyridin-3- y)methyl)-3-methyl-5-(2- (trifluoromethyl)pyridin-3-yl)-1H-pyrazolo[4,3- b]pyridin-7-amine::US11026923, Example 183::US11491140, Example 183 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 290 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501554 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501554&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 155642144 459086745 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223406 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C(F)F)c2n1)C(C)C InChI=1S/C22H25F2N7O/c1-5-32-22-15(7-6-8-25-22)16-9-17(26-10-14-11-27-30(4)12-14)20-18(28-16)19(21(23)24)29-31(20)13(2)3/h6-9,11-13,21H,5,10H2,1-4H3,(H,26,28) YFAHCXPQQYYPCW-UHFFFAOYSA-N 279153 3-(difluoromethyl)-5-(2-ethoxypyridin-3-yl)-1-isopropyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 184::US10512632, Example 184::US10618913, Example S184::US10766893, Example S184::US10806718, Example 184::US11491140, Example 184::US11634416, Example 184 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 13.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279153&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273473 378160730 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223409 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-n1cncn1 InChI=1S/C17H21N9/c1-11(2)26-17-14(19-6-13-7-20-24(4)8-13)5-15(25-10-18-9-21-25)22-16(17)12(3)23-26/h5,7-11H,6H2,1-4H3,(H,19,22) VELNJFTUSCXPKE-UHFFFAOYSA-N 279154 1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-5-(1H-1,2,4-triazol-1-yl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 185::US10512632, Example 185::US10766893, Example S185::US10806718, Example 185::US11026923, Example 185::US11491140, Example 185::US11634416, Example 185 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 100.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279154&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273474 378160731 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223412 CC(C)n1nc(C)c2nc(cc(NCc3ncn(C)n3)c12)-c1ccc[nH]c1=O InChI=1S/C19H22N8O/c1-11(2)27-18-15(21-9-16-22-10-26(4)25-16)8-14(23-17(18)12(3)24-27)13-6-5-7-20-19(13)28/h5-8,10-11H,9H2,1-4H3,(H,20,28)(H,21,23) LRKYMHYCQWOGDT-UHFFFAOYSA-N 279155 3-[1-isopropyl-3-methyl-7-[(1-methyl-1,2,4-triazol-3-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]-1H-pyridin-2-one::US10034861, Example 186::US10512632, Example 186::US10766893, Example S186::US10806718, Example 186::US11026923, Example 186::US11491140, Example 186::US11634416, Example 186 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 64.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279155&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 136214894 378160732 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223415 CC(C)n1nc(C)c2nc(cc(NCc3cc[nH]n3)c12)-c1ccc[nH]c1=O InChI=1S/C19H21N7O/c1-11(2)26-18-16(21-10-13-6-8-22-24-13)9-15(23-17(18)12(3)25-26)14-5-4-7-20-19(14)27/h4-9,11H,10H2,1-3H3,(H,20,27)(H,21,23)(H,22,24) FWAXXZSYYYRIBS-UHFFFAOYSA-N 279156 3-[1-isopropyl-3-methyl-7-(1H-pyrazol-3-ylmethylamino)pyrazolo[4,3-b]pyridin-5-yl]-1H-pyridin-2-one::US10034861, Example 187::US10512632, Example 187::US10766893, Example S187::US10806718, Example 187::US11026923, Example 187::US11491140, Example 187::US11634416, Example 187 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 140 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279156&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 136214895 378160733 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223418 COc1ncccc1CNc1cc(nc2c(C)nn(C(C)C)c12)-c1cccnc1OC(F)F InChI=1S/C23H24F2N6O2/c1-13(2)31-20-18(28-12-15-7-5-9-26-21(15)32-4)11-17(29-19(20)14(3)30-31)16-8-6-10-27-22(16)33-23(24)25/h5-11,13,23H,12H2,1-4H3,(H,28,29) HFYVDFFGOVRRIK-UHFFFAOYSA-N 279157 5-[2-(difluoromethoxy)-3-pyridyl]-1-isopropyl-N-[(2-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 188::US10512632, Example 188::US10766893, Example S188::US11026923, Example 188::US11491140, Example 188::US11634416, Example 188 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 61.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279157&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273478 378160734 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223421 CCOc1ncccc1-c1cc(NCc2nccc(OC)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O2/c1-6-32-23-16(8-7-10-25-23)17-12-18(26-13-19-24-11-9-20(28-19)31-5)22-21(27-17)15(4)29-30(22)14(2)3/h7-12,14H,6,13H2,1-5H3,(H,26,27) ZRCQWXKCYCHOGM-UHFFFAOYSA-N 279158 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(4-methoxypyrimidin-2-yl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 189::US10512632, Example 189::US10766893, Example S189::US10806718, Example 189::US11026923, Example 189::US11491140, Example 189::US11634416, Example 189 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 3.90 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279158&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273477 378160735 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223424 CCOc1ncccc1-c1cc(NCc2cncnc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O2/c1-6-32-23-17(8-7-9-25-23)18-10-19(26-12-16-11-24-13-27-22(16)31-5)21-20(28-18)15(4)29-30(21)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,26,28) FQSCOMBJMAVYMG-UHFFFAOYSA-N 279159 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(4-methoxypyrimidin-5-yl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 190::US10512632, Example 190::US10766893, Example S190::US10806718, Example 190::US11026923, Example 190::US11491140, Example 190::US11634416, Example 190 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 74.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279159&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273480 378160736 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223427 CCOc1ncccc1CNc1cc(nc2c(C)nn(C(C)C)c12)-c1cccnc1OCC InChI=1S/C25H30N6O2/c1-6-32-24-18(10-8-12-26-24)15-28-21-14-20(19-11-9-13-27-25(19)33-7-2)29-22-17(5)30-31(16(3)4)23(21)22/h8-14,16H,6-7,15H2,1-5H3,(H,28,29) RPFGIRQWMRKNBU-UHFFFAOYSA-N 279160 5-(2-ethoxy-3-pyridyl)-N-[(2-ethoxy-3-pyridyl)methyl]-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 191::US10512632, Example 191::US10766893, Example S191::US10806718, Example 191::US11026923, Example 191::US11491140, Example 191::US11634416, Example 191 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 160 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279160&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273479 378160737 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223430 COc1ccc(CNc2cc(nc3c(C)nn(C(C)C)c23)-c2cccnc2N(C)C)cc1 InChI=1S/C25H30N6O/c1-16(2)31-24-22(27-15-18-9-11-19(32-6)12-10-18)14-21(28-23(24)17(3)29-31)20-8-7-13-26-25(20)30(4)5/h7-14,16H,15H2,1-6H3,(H,27,28) RMYFPLHNAGFJMC-UHFFFAOYSA-N 279161 5-[2-(dimethylamino)-3-pyridyl]-1-isopropyl-N-[(4-methoxyphenyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 192::US10512632, Example 192::US10766893, Example S192::US10806718, Example 192::US11026923, Example 192::US11491140, Example 192::US11634416, Example 192 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 630 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279161&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273481 378160738 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223433 CC(C)n1nc(C)c2nc(cc(NCc3cccnc3C(F)(F)F)c12)-c1ccc[nH]c1=O InChI=1S/C22H21F3N6O/c1-12(2)31-19-17(28-11-14-6-4-8-26-20(14)22(23,24)25)10-16(29-18(19)13(3)30-31)15-7-5-9-27-21(15)32/h4-10,12H,11H2,1-3H3,(H,27,32)(H,28,29) CEASKHHYUJNGEA-UHFFFAOYSA-N 279162 3-[1-isopropyl-3-methyl-7-[[2-(trifluoromethyl)-3-pyridyl]methylamino]pyrazolo[4,3-b]pyridin-5-yl]-1H-pyridin-2-one::US10034861, Example 193::US10512632, Example 193::US10766893, Example S193::US10806718, Example 193::US11491140, Example 193::US11634416, Example 193 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 320 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279162&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 136214896 378160739 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223436 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1conc1C InChI=1S/C19H23N7O/c1-11(2)26-19-17(20-7-14-8-21-25(5)9-14)6-16(15-10-27-24-12(15)3)22-18(19)13(4)23-26/h6,8-11H,7H2,1-5H3,(H,20,22) MTWLSLCQXJXQNM-UHFFFAOYSA-N 279163 1-isopropyl-3-methyl-5-(3-methylisoxazol-4-yl)-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 194::US10512632, Example 194::US10766893, Example S194::US10806718, Example 194::US11491140, Example 194::US11634416, Example 194 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 95.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279163&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273485 378160740 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223439 CC(C)n1nc(C)c2nc(cc(NCc3ccn(C)c3)c12)-c1ncnn1C InChI=1S/C19H24N8/c1-12(2)27-18-15(20-9-14-6-7-25(4)10-14)8-16(19-21-11-22-26(19)5)23-17(18)13(3)24-27/h6-8,10-12H,9H2,1-5H3,(H,20,23) XFUMOUGBVYWUFH-UHFFFAOYSA-N 580620 1-isopropyl-3-methyl-5-(1-methyl-1H-1,2,4- triazol-5-yl)-N-((1-methyl-1H-pyrazol-4- yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US11491140, Example 195 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 420 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=580620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=580620&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 155305237 475726464 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223442 CCCOc1ncccc1-c1cc(NCc2cn[nH]c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H27N7O/c1-5-9-30-22-17(7-6-8-23-22)18-10-19(24-11-16-12-25-26-13-16)21-20(27-18)15(4)28-29(21)14(2)3/h6-8,10,12-14H,5,9,11H2,1-4H3,(H,24,27)(H,25,26) FTOYLOIRXWDMMT-UHFFFAOYSA-N 279165 1-isopropyl-3-methyl-5-(2-propoxy-3-pyridyl)-N-(1H-pyrazol-4-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 196::US10512632, Example 196::US11491140, Example 196::US11634416, Example 196 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 18.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279165&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273488 378160742 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223445 CCOc1ncccc1-c1cc(NCc2cccnc2OC)c2n(nc(C)c2n1)C1COC1 InChI=1S/C24H26N6O3/c1-4-33-24-18(8-6-10-26-24)19-11-20(27-12-16-7-5-9-25-23(16)31-3)22-21(28-19)15(2)29-30(22)17-13-32-14-17/h5-11,17H,4,12-14H2,1-3H3,(H,27,28) GRFJYHDUOKDAKO-UHFFFAOYSA-N 279166 5-(2-ethoxy-3-pyridyl)-N-[(2-methoxy-3-pyridyl)methyl]-3-methyl-1-(oxetan-3-yl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 197::US10512632, Example 197::US10618913, Example S197::US10766893, Example S197::US10806718, Example 197::US11491140, Example 197::US11634416, Example 197 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 190 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279166&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273484 378160743 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223448 CCN(C)c1ncccc1-c1cc(NCc2ccc(OC)cc2)c2n(nc(C)c2n1)C(C)C InChI=1S/C26H32N6O/c1-7-31(5)26-21(9-8-14-27-26)22-15-23(28-16-19-10-12-20(33-6)13-11-19)25-24(29-22)18(4)30-32(25)17(2)3/h8-15,17H,7,16H2,1-6H3,(H,28,29) YNHQWVLFISTQIU-UHFFFAOYSA-N 279167 5-(2-(ethyl(methyl)amino)pyridin-3-yl)-1-isopropyl-N-(4-methoxybenzyl)-3-methyl-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 198::US10512632, Example 198::US10766893, Example S198::US10806718, Example 198::US11026923, Example 198::US11491140, Example 198::US11634416, Example 198 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1100 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279167 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279167&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273483 378160744 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223451 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(CF)c2n1)C(C)C InChI=1S/C22H26FN7O/c1-5-31-22-16(7-6-8-24-22)17-9-18(25-11-15-12-26-29(4)13-15)21-20(27-17)19(10-23)28-30(21)14(2)3/h6-9,12-14H,5,10-11H2,1-4H3,(H,25,27) CRFWOMGBISLKHY-UHFFFAOYSA-N 279168 5-(2-ethoxypyridin-3-yl)-3-(fluoromethyl)-1-isopropyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 199::US10512632, Example 199::US10618913, Example S199::US10766893, Example S199::US10806718, Example 199::US11026923, Example 199::US11491140, Example 199::US11634416, Example 199 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 7.40 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279168&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273487 378160745 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1222860 CCOc1ncccc1-c1cc(NCc2nnc(C)o2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H25N7O2/c1-6-29-21-15(8-7-9-22-21)16-10-17(23-11-18-26-25-14(5)30-18)20-19(24-16)13(4)27-28(20)12(2)3/h7-10,12H,6,11H2,1-5H3,(H,23,24) XEBJMVLHZBRKST-UHFFFAOYSA-N 278971 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methyl-1,3,4-oxadiazol-2-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 1::US10512632, Example 1::US10618913, Example S1::US10766893, Example S1::US10806718, Example 1::US11026923, Example 1::US11491140, Example 1::US11634416, Example 1 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 18.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278971 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278971&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273299 378160560 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1222863 CCOc1ncccc1-c1cc(NCc2ncc(C)s2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6OS/c1-6-29-22-16(8-7-9-23-22)17-10-18(24-12-19-25-11-14(4)30-19)21-20(26-17)15(5)27-28(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,24,26) QOYNQFLWGDTXKT-UHFFFAOYSA-N 278972 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methylthiazol-2-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 2::US10512632, Example 2::US10766893, Example S2::US10806718, Example 2::US11026923, Example 2::US11491140, Example 2::US11634416, Example 2 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.460 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278972 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278972&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273301 378160561 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1222866 CCOc1ncccc1-c1cc(NCc2cc(C)on2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6O2/c1-6-29-22-17(8-7-9-23-22)18-11-19(24-12-16-10-14(4)30-27-16)21-20(25-18)15(5)26-28(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,24,25) MKELJWFWEJOZNC-UHFFFAOYSA-N 278973 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methylisoxazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 3::US10512632, Example 3::US10766893, Example S3::US10806718, Example 3::US11026923, Example 3::US11491140, Example 3::US11634416, Example 3 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.800 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278973&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273302 378160562 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1222869 CCOc1ncccc1-c1cc(NCc2cnc(C)o2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6O2/c1-6-29-22-17(8-7-9-23-22)18-10-19(25-12-16-11-24-15(5)30-16)21-20(26-18)14(4)27-28(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,25,26) TWDRBTLHNZMOLP-UHFFFAOYSA-N 278974 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methyloxazol-5-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 4::US10512632, Example 4::US10766893, Example S4::US10806718, Example 4::US11026923, Example 4::US11491140, Example 4::US11634416, Example 4 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.60 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278974 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278974&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273304 378160563 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1222872 CCOc1ncccc1-c1cc(NCc2cnn(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-6-30-21-16(8-7-9-22-21)17-10-18(23-11-15-12-24-28(5)27-15)20-19(25-17)14(4)26-29(20)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,23,25) RKVBYUMNPKGITG-UHFFFAOYSA-N 278975 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methyltriazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 5::US10512632, Example 5::US10766893, Example S5::US10806718, Example 5::US11026923, Example 5::US11491140, Example 5::US11634416, Example 5 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 11.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278975&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273303 378160564 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1222875 CCOc1ncccc1-c1cc(NCc2cn(C)nn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-6-30-21-16(8-7-9-22-21)17-10-18(23-11-15-12-28(5)27-25-15)20-19(24-17)14(4)26-29(20)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,23,24) GZZVSCZGHCUFQG-UHFFFAOYSA-N 278976 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(1-methyltriazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 6::US10512632, Example 6::US10766893, Example S6::US10806718, Example 6::US11026923, Example 6::US11491140, Example 6::US11634416, Example 6 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4.80 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278976&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273306 378160565 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223454 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1ocnc1C InChI=1S/C19H23N7O/c1-11(2)26-18-15(20-7-14-8-22-25(5)9-14)6-16(19-13(4)21-10-27-19)23-17(18)12(3)24-26/h6,8-11H,7H2,1-5H3,(H,20,23) JVGYDVFOXCBHRN-UHFFFAOYSA-N 279169 1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-5-(4-methyloxazol-5-yl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 200::US10512632, Example 200::US10618913, Example S200::US10766893, Example S200::US10806718, Example 200::US11026923, Example 200::US11491140, Example 200::US11634416, Example 200 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 98.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279169&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273489 378160746 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223457 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1cccnc1N(C)C InChI=1S/C22H28N8/c1-14(2)30-21-19(24-11-16-12-25-29(6)13-16)10-18(26-20(21)15(3)27-30)17-8-7-9-23-22(17)28(4)5/h7-10,12-14H,11H2,1-6H3,(H,24,26) JWSSTJTVRAZILB-UHFFFAOYSA-N 279170 5-[2-(dimethylamino)-3-pyridyl]-1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 201::US10512632, Example 201::US10766893, Example S201::US10806718, Example 201::US11026923, Example 201::US11491140, Example 201::US11634416, Example 201 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2100 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279170&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273490 378160747 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223460 CC(C)n1nc(C)c2nc(cc(NCc3ccn(C)c3)c12)-c1nc(C)co1 InChI=1S/C20H24N6O/c1-12(2)26-19-16(21-9-15-6-7-25(5)10-15)8-17(20-22-13(3)11-27-20)23-18(19)14(4)24-26/h6-8,10-12H,9H2,1-5H3,(H,21,23) GPONGJLPFFHLFQ-UHFFFAOYSA-N 580627 1-isopropyl-3-methyl-N-((1-methyl-1H- pyrazol-4-yl)methyl)-5-(4-methyloxazol-2-yl)- 1H-pyrazolo[4,3-b]pyridin-7-amine::US11491140, Example 202 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 92.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=580627 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=580627&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 155305745 475726471 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223463 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1nncn1C InChI=1S/C18H23N9/c1-11(2)27-17-14(19-7-13-8-21-26(5)9-13)6-15(18-23-20-10-25(18)4)22-16(17)12(3)24-27/h6,8-11H,7H2,1-5H3,(H,19,22) KAIFDCSXZCWWKF-UHFFFAOYSA-N 279172 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-(4-methyl-1,2,4-triazol-3-::US10034861, Example 203::US10512632, Example 203::US10766893, Example S203::US10806718, Example 203::US11026923, Example 203::US11491140, Example 203::US11634416, Example 203 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 410 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279172 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279172&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273492 378160749 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1222878 CCOc1ncccc1-c1cc(NCc2cn[nH]c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H25N7O/c1-5-29-21-16(7-6-8-22-21)17-9-18(23-10-15-11-24-25-12-15)20-19(26-17)14(4)27-28(20)13(2)3/h6-9,11-13H,5,10H2,1-4H3,(H,23,26)(H,24,25) ZBYZXMQLZZULRF-UHFFFAOYSA-N 278977 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1H-pyrazol-4-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 7::US10512632, Example 7::US10766893, Example S7::US10806718, Example 7::US11026923, Example 7::US11491140, Example 7::US11634416, Example 7 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 21.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278977 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278977&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 136214891 378160566 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1222881 CCOc1ncccc1-c1cc(NCc2nnn(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C20H25N9O/c1-6-30-20-14(8-7-9-21-20)15-10-16(22-11-17-24-27-28(5)26-17)19-18(23-15)13(4)25-29(19)12(2)3/h7-10,12H,6,11H2,1-5H3,(H,22,23) MMFBNAADCPOKBP-UHFFFAOYSA-N 278978 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methyltetrazol-5-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 8::US10512632, Example 8::US10766893, Example S8::US10806718, Example 8::US11491140, Example 8::US11634416, Example 8 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.90 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278978&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273308 378160567 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1222884 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H27N7O/c1-6-30-22-17(8-7-9-23-22)18-10-19(24-11-16-12-25-28(5)13-16)21-20(26-18)15(4)27-29(21)14(2)3/h7-10,12-14H,6,11H2,1-5H3,(H,24,26) IGZQEXMDAKABFO-UHFFFAOYSA-N 278979 5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 9::US10512632, Example 9::US10766893, Example S9::US10806718, Example 9::US11491140, Example 9::US11634416, Example 9 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.60 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278979&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273307 378160568 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1222887 CCOc1ncccc1-c1cc(NCc2cc(C)no2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6O2/c1-6-29-22-17(8-7-9-23-22)18-11-19(24-12-16-10-14(4)27-30-16)21-20(25-18)15(5)26-28(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,24,25) WAUSGEZRVANNBG-UHFFFAOYSA-N 278980 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(3-methylisoxazol-5-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 10::US10512632, Example 10::US10766893, Example S10::US10806718, Example 10::US11491140, Example 10::US11634416, Example 10 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4.10 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278980 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278980&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273310 378160569 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1222890 CCOc1ncccc1-c1cc(NCc2csc(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6OS/c1-6-29-22-17(8-7-9-23-22)18-10-19(24-11-16-12-30-15(5)25-16)21-20(26-18)14(4)27-28(21)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,24,26) YDCVOKZJZPJMKM-UHFFFAOYSA-N 278981 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methylthiazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 11::US10512632, Example 11::US10766893, Example S11::US10806718, Example 11::US11491140, Example 11::US11634416, Example 11 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 9.60 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278981&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273309 378160570 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1222893 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C1CC1 InChI=1S/C22H25N7O/c1-4-30-22-17(6-5-9-23-22)18-10-19(24-11-15-12-25-28(3)13-15)21-20(26-18)14(2)27-29(21)16-7-8-16/h5-6,9-10,12-13,16H,4,7-8,11H2,1-3H3,(H,24,26) SVNBZNOJEMDHHP-UHFFFAOYSA-N 278982 1-cyclopropyl-5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 12::US10512632, Example 12::US10618913, Example S12::US10766893, Example S12::US10806718, Example 12::US11026923, Example 12::US11491140, Example 12 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 200 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278982&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273311 378160571 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1222896 CCCn1ncc2nc(cc(NCc3cnn(C)c3)c12)-c1cccnc1OCC InChI=1S/C21H25N7O/c1-4-9-28-20-18(23-11-15-12-24-27(3)14-15)10-17(26-19(20)13-25-28)16-7-6-8-22-21(16)29-5-2/h6-8,10,12-14H,4-5,9,11H2,1-3H3,(H,23,26) VBBYLKGVLRZVDT-UHFFFAOYSA-N 278983 5-(2-ethoxy-3-pyridyl)-N-[(1-methylpyrazol-4-yl)methyl]-1-propyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 13::US10512632, Example 13::US10618913, Example S13::US10766893, Example S13::US10806718, Example 13::US11026923, Example 13::US11491140, Example 13::US11634416, Example 13 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 90.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278983 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278983&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273312 378160572 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1222899 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(ncc2n1)C1COC1 InChI=1S/C21H23N7O2/c1-3-30-21-16(5-4-6-22-21)17-7-18(23-8-14-9-24-27(2)11-14)20-19(26-17)10-25-28(20)15-12-29-13-15/h4-7,9-11,15H,3,8,12-13H2,1-2H3,(H,23,26) BRAWZTIBDHEBNS-UHFFFAOYSA-N 278984 5-(2-ethoxypyridin-3-yl)-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1-(oxetan-3-yl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 14::US10512632, Example 14::US10618913, Example S14::US10766893, Example S14::US10806718, Example 14::US11026923, Example 14::US11491140, Example 14::US11634416, Example 14 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 450 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278984 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278984&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273313 378160573 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1222902 CCOc1ncccc1-c1cc(NC(C)c2cnn(C)c2)c2n(C)ncc2n1 InChI=1S/C20H23N7O/c1-5-28-20-15(7-6-8-21-20)16-9-17(19-18(25-16)11-23-27(19)4)24-13(2)14-10-22-26(3)12-14/h6-13H,5H2,1-4H3,(H,24,25) PRZKTPKTSVRPRD-UHFFFAOYSA-N 278985 5-(2-ethoxypyridin-3-yl)-1-methyl-N-(1-(1-methyl-1H-pyrazol-4-yl)ethyl)-1H-pyrazolo[4,3-b]pyridin-7-amine (racemic)::US10034861, Example 15::US10766893, Example S15::US10806718, Example 15::US11026923, Example 15::US11491140, Example 15 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 820 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278985 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278985&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273314 378160574 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1222905 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(C)ncc2n1 InChI=1S/C19H21N7O/c1-4-27-19-14(6-5-7-20-19)15-8-16(18-17(24-15)11-23-26(18)3)21-9-13-10-22-25(2)12-13/h5-8,10-12H,4,9H2,1-3H3,(H,21,24) IHPVHEUBCHVJEQ-UHFFFAOYSA-N 278986 5-(2-ethoxypyridin-3-yl)-1-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 16::US10512632, Example 16::US10766893, Example S16::US10806718, Example 16::US11026923, Example 16::US11491140, Example 16 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 670 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278986&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273315 378160575 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1222908 CCOc1ncccc1-c1cc(NCc2nccn2C)c2n(ncc2n1)C(C)C InChI=1S/C21H25N7O/c1-5-29-21-15(7-6-8-23-21)16-11-17(24-13-19-22-9-10-27(19)4)20-18(26-16)12-25-28(20)14(2)3/h6-12,14H,5,13H2,1-4H3,(H,24,26) XRIYYPDCPKIHRW-UHFFFAOYSA-N 278987 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimidazol-2-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 17::US10512632, Example 17::US10618913, Example S17::US10766893, Example S17::US10806718, Example 17::US11026923, Example 17::US11491140, Example 17::US11634416, Example 17 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 700 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278987 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278987&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273316 378160576 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1222911 CCOc1ncccc1-c1cc(NCc2ccnn2C)c2n(ncc2n1)C(C)C InChI=1S/C21H25N7O/c1-5-29-21-16(7-6-9-22-21)17-11-18(23-12-15-8-10-24-27(15)4)20-19(26-17)13-25-28(20)14(2)3/h6-11,13-14H,5,12H2,1-4H3,(H,23,26) ARZYUJKMHFQSRW-UHFFFAOYSA-N 278988 5-(2-ethoxypyridin-3-yl)-1-isopropyl-N-((1-methyl-1H-pyrazol-5-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 18::US10512632, Example 18::US10766893, Example S18::US10806718, Example 18::US11026923, Example 18::US11491140, Example 18::US11634416, Example 18 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 450 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278988&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273317 378160577 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1222914 CCOc1ncccc1-c1cc(NCc2ccn(C)n2)c2n(ncc2n1)C(C)C InChI=1S/C21H25N7O/c1-5-29-21-16(7-6-9-22-21)17-11-18(23-12-15-8-10-27(4)26-15)20-19(25-17)13-24-28(20)14(2)3/h6-11,13-14H,5,12H2,1-4H3,(H,23,25) KZFYUJZMDBTCDC-UHFFFAOYSA-N 278989 5-(2-ethoxypyridin-3-yl)-1-isopropyl-N-((1-methyl-1H-pyrazol-3-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 19::US10512632, Example 19::US10766893, Example S19::US10806718, Example 19::US11026923, Example 19::US11491140, Example 19::US11634416, Example 19 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 66.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278989 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278989&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273318 378160578 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1222917 CCOc1ncccc1-c1cc(NCc2nccs2)c2n(ncc2n1)C(C)C InChI=1S/C20H22N6OS/c1-4-27-20-14(6-5-7-22-20)15-10-16(23-12-18-21-8-9-28-18)19-17(25-15)11-24-26(19)13(2)3/h5-11,13H,4,12H2,1-3H3,(H,23,25) ICTYYJZHJNSZFG-UHFFFAOYSA-N 278990 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-(thiazol-2-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 20::US10512632, Example 20::US10766893, Example S20::US10806718, Example 20::US11026923, Example 20::US11491140, Example 20::US11634416, Example 20 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 520 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278990&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273319 378160579 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1222920 CCOc1ncccc1-c1cc(NCc2cn(C)cn2)c2n(ncc2n1)C(C)C InChI=1S/C21H25N7O/c1-5-29-21-16(7-6-8-22-21)17-9-18(23-10-15-12-27(4)13-24-15)20-19(26-17)11-25-28(20)14(2)3/h6-9,11-14H,5,10H2,1-4H3,(H,23,26) GPZPPQFWVLHHBU-UHFFFAOYSA-N 278991 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimidazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 21::US10512632, Example 21::US10766893, Example S21::US10806718, Example 21::US11026923, Example 21::US11491140, Example 21::US11634416, Example 21 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.90 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278991&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273320 378160580 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1222923 CCOc1ncccc1-c1cc(NCc2ccncc2)c2n(ncc2n1)C(C)C InChI=1S/C22H24N6O/c1-4-29-22-17(6-5-9-24-22)18-12-19(25-13-16-7-10-23-11-8-16)21-20(27-18)14-26-28(21)15(2)3/h5-12,14-15H,4,13H2,1-3H3,(H,25,27) HEERUKANWGHTOL-UHFFFAOYSA-N 278992 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-(4-pyridylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 22::US10512632, Example 22::US10766893, Example S22::US10806718, Example 22::US11026923, Example 22::US11491140, Example 22::US11634416, Example 22 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 250 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278992&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273322 378160581 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1222926 CCOc1ncccc1-c1cc(NCc2cccc(C)c2)c2n(ncc2n1)C(C)C InChI=1S/C24H27N5O/c1-5-30-24-19(10-7-11-25-24)20-13-21(26-14-18-9-6-8-17(4)12-18)23-22(28-20)15-27-29(23)16(2)3/h6-13,15-16H,5,14H2,1-4H3,(H,26,28) NOGPVEPEDSPNHF-UHFFFAOYSA-N 278993 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-(m-tolylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 23::US10512632, Example 23::US10618913, Example S23::US10766893, Example S23::US10806718, Example 23::US11026923, Example 23::US11491140, Example 23::US11634416, Example 23 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 240 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278993&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273321 378160582 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1222929 CCOc1ncccc1-c1cc(NCc2ccc(C)cc2)c2n(ncc2n1)C(C)C InChI=1S/C24H27N5O/c1-5-30-24-19(7-6-12-25-24)20-13-21(26-14-18-10-8-17(4)9-11-18)23-22(28-20)15-27-29(23)16(2)3/h6-13,15-16H,5,14H2,1-4H3,(H,26,28) KLXXAXDPPNWJOU-UHFFFAOYSA-N 278994 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-(p-tolylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 24::US10512632, Example 24::US10766893, Example S24::US10806718, Example 24::US11026923, Example 24::US11491140, Example 24::US11634416, Example 24 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 380 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278994&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273323 378160583 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1222932 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(ncc2n1)C(C)C InChI=1S/C21H25N7O/c1-5-29-21-16(7-6-8-22-21)17-9-18(23-10-15-11-24-27(4)13-15)20-19(26-17)12-25-28(20)14(2)3/h6-9,11-14H,5,10H2,1-4H3,(H,23,26) PLERDTYSXFBCOL-UHFFFAOYSA-N 278995 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 25::US10512632, Example 25::US10766893, Example S25::US10806718, Example 25::US11026923, Example 25::US11491140, Example 25::US11634416, Example 25 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 56.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278995&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273324 378160584 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1222935 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(CC)ncc2n1 InChI=1S/C20H23N7O/c1-4-27-19-17(22-10-14-11-23-26(3)13-14)9-16(25-18(19)12-24-27)15-7-6-8-21-20(15)28-5-2/h6-9,11-13H,4-5,10H2,1-3H3,(H,22,25) GDQVLYVPAWKIKI-UHFFFAOYSA-N 424936 US10512632, Example 26::US10618913, Example S26::US10766893, Example S26::US10806718, Example 26::US11026923, Example 26::US11491140, Example 26::US11634416, Example 26 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 140 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=424936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=424936&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138536209 434150491 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1222938 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C1COC1 InChI=1S/C22H25N7O2/c1-4-31-22-17(6-5-7-23-22)18-8-19(24-9-15-10-25-28(3)11-15)21-20(26-18)14(2)27-29(21)16-12-30-13-16/h5-8,10-11,16H,4,9,12-13H2,1-3H3,(H,24,26) HKTCICUQHUTDJM-UHFFFAOYSA-N 278997 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-1-(oxetan-3-yl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 27::US10512632, Example 27::US10766893, Example S27::US10806718, Example 27::US11026923, Example 27::US11491140, Example 27::US11634416, Example 27 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 94.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278997 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278997&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273326 378160586 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1222941 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(C)nc(C)c2n1 InChI=1S/C20H23N7O/c1-5-28-20-15(7-6-8-21-20)16-9-17(22-10-14-11-23-26(3)12-14)19-18(24-16)13(2)25-27(19)4/h6-9,11-12H,5,10H2,1-4H3,(H,22,24) GGQMHLLGYDUHDQ-UHFFFAOYSA-N 278998 5-(2-ethoxy-3-pyridyl)-1,3-dimethyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 28::US10512632, Example 28::US10618913, Example S28::US10766893, Example S28::US10806718, Example 28::US11026923, Example 28::US11491140, Example 28::US11634416, Example 28 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 550 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278998 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278998&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273327 378160587 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1222944 CCOc1ncccc1-c1cc(NCc2nc(C)cs2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6OS/c1-6-29-22-16(8-7-9-23-22)17-10-18(24-11-19-25-14(4)12-30-19)21-20(26-17)15(5)27-28(21)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,24,26) WFSFSRAGPIZNCC-UHFFFAOYSA-N 278999 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(4-methylthiazol-2-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 29::US10512632, Example 29::US10618913, Example S162::US10766893, Example S29::US10806718, Example 29::US11026923, Example 29::US11491140, Example 29::US11634416, Example 29 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 27.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278999 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278999&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273328 378160588 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1222947 CCOc1ncccc1-c1cc(NCc2nc(C)no2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H25N7O2/c1-6-29-21-15(8-7-9-22-21)16-10-17(23-11-18-24-14(5)27-30-18)20-19(25-16)13(4)26-28(20)12(2)3/h7-10,12H,6,11H2,1-5H3,(H,23,25) ZPMKSBYSMXCOIZ-UHFFFAOYSA-N 279000 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(3-methyl-1,2,4-oxadiazol-5-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 30::US10512632, Example 30::US10766893, Example S30::US10806718, Example 30::US11026923, Example 30::US11491140, Example 30::US11634416, Example 30 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 15.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279000 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279000&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273329 378160589 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1222950 CCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-6-30-21-15(8-7-9-22-21)16-10-17(23-11-18-24-12-28(5)27-18)20-19(25-16)14(4)26-29(20)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,23,25) CJOUFKUESMXTOX-UHFFFAOYSA-N 279001 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 161::US10034861, Example 31::US10512632, Example 31::US10766893, Example S31::US10806718, Example 31::US11026923, Example 31::US11491140, Example 31::US11634416, Example 31 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.20 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279001 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279001&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273330 378160590 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1222953 CCOc1ncccc1-c1cc(NCc2cnc(C)s2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6OS/c1-6-29-22-17(8-7-9-23-22)18-10-19(25-12-16-11-24-15(5)30-16)21-20(26-18)14(4)27-28(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,25,26) UJFBEAPRUYBIKE-UHFFFAOYSA-N 279002 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methylthiazol-5-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 32::US10512632, Example 32::US10766893, Example S32::US10806718, Example 32::US11026923, Example 32::US11491140, Example 32::US11634416, Example 32 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4.60 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279002&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273331 378160591 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1222956 CCOc1ncccc1-c1cc(NCc2nnc(C)s2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H25N7OS/c1-6-29-21-15(8-7-9-22-21)16-10-17(23-11-18-26-25-14(5)30-18)20-19(24-16)13(4)27-28(20)12(2)3/h7-10,12H,6,11H2,1-5H3,(H,23,24) XQUFGMNXDPCXMM-UHFFFAOYSA-N 279003 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methyl-1,3,4-thiadiazol-2-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 33::US10512632, Example 33::US10766893, Example S33::US10806718, Example 33::US11026923, Example 33::US11491140, Example 33::US11634416, Example 33 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.60 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279003 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279003&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273332 378160592 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1222959 CCOc1ncccc1-c1cc(NCc2csc(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N5OS/c1-6-29-23-18(8-7-9-24-23)19-11-20(25-12-17-10-15(4)30-13-17)22-21(26-19)16(5)27-28(22)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,25,26) VNCLCBKVWWHCAF-UHFFFAOYSA-N 279004 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methyl-3-thienyl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 34::US10512632, Example 34::US10766893, Example S34::US10806718, Example 34::US11026923, Example 34::US11491140, Example 34::US11634416, Example 34 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.10 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279004 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279004&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273333 378160593 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1222962 CCOc1ncccc1-c1cc(NCc2cc(C)cs2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N5OS/c1-6-29-23-18(8-7-9-24-23)19-11-20(25-12-17-10-15(4)13-30-17)22-21(26-19)16(5)27-28(22)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,25,26) DHODKXCCORNYHA-UHFFFAOYSA-N 279005 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(4-methyl-2-thienyl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 35::US10512632, Example 35::US10766893, Example S35::US10806718, Example 35::US11026923, Example 35::US11491140, Example 35::US11634416, Example 35 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 7.30 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279005 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279005&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273334 378160594 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1222965 CCOc1ncccc1-c1cc(NCc2ccc(C)s2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N5OS/c1-6-29-23-18(8-7-11-24-23)19-12-20(25-13-17-10-9-15(4)30-17)22-21(26-19)16(5)27-28(22)14(2)3/h7-12,14H,6,13H2,1-5H3,(H,25,26) MXNGXYQZCMFPJD-UHFFFAOYSA-N 279006 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methyl-2-thienyl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 36::US10512632, Example 36::US10766893, Example S36::US10806718, Example 36::US11026923, Example 36::US11491140, Example 36::US11634416, Example 36 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 24.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279006&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273337 378160595 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1222968 CCOc1ncccc1-c1cc(NCc2coc(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6O2/c1-6-29-22-17(8-7-9-23-22)18-10-19(24-11-16-12-30-15(5)25-16)21-20(26-18)14(4)27-28(21)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,24,26) VZTGUNQMZSOPTA-UHFFFAOYSA-N 279007 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methyloxazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 37::US10512632, Example 37::US10766893, Example S37::US10806718, Example 37::US11026923, Example 37::US11491140, Example 37::US11634416, Example 37 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 5.90 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279007 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279007&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273335 378160596 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1222971 CCOc1ncccc1-c1cc(NCc2ncc(C)o2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6O2/c1-6-29-22-16(8-7-9-23-22)17-10-18(24-12-19-25-11-14(4)30-19)21-20(26-17)15(5)27-28(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,24,26) IGMSFVIKHQRGSP-UHFFFAOYSA-N 279008 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methyloxazol-2-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 38::US10512632, Example 38::US10766893, Example S38::US10806718, Example 38::US11026923, Example 38::US11491140, Example 38::US11634416, Example 38 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.10 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279008 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279008&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273338 378160597 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1222974 CCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H25N7O/c1-5-29-21-16(7-6-9-22-21)17-11-18(23-12-15-8-10-24-26-15)20-19(25-17)14(4)27-28(20)13(2)3/h6-11,13H,5,12H2,1-4H3,(H,23,25)(H,24,26) UOWVOVPKNPTQQH-UHFFFAOYSA-N 279009 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 39::US10512632, Example 39::US10766893, Example S39::US10806718, Example 39::US11026923, Example 39::US11491140, Example 39::US11634416, Example 39 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.10 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279009 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279009&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273340 378160598 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1222977 CCOc1ncccc1-c1cc(NCc2c[nH]cn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H25N7O/c1-5-29-21-16(7-6-8-23-21)17-9-18(24-11-15-10-22-12-25-15)20-19(26-17)14(4)27-28(20)13(2)3/h6-10,12-13H,5,11H2,1-4H3,(H,22,25)(H,24,26) IQIUSKXHLPBBOV-UHFFFAOYSA-N 279010 5-(2-ethoxy-3-pyridyl)-N-(1H-imidazol-4-ylmethyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 40::US10512632, Example 40::US10766893, Example S40::US10806718, Example 40::US11026923, Example 40::US11491140, Example 40::US11634416, Example 40 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 14.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279010 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279010&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273339 378160599 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1222980 CCOc1ncccc1-c1cc(NCc2ccccc2)c(NC(C)C)c(C=N)n1 InChI=1S/C23H27N5O/c1-4-29-23-18(11-8-12-25-23)19-13-20(26-15-17-9-6-5-7-10-17)22(27-16(2)3)21(14-24)28-19/h5-14,16,24,27H,4,15H2,1-3H3,(H,26,28) LIQGIDGFAWHICN-UHFFFAOYSA-N 580432 N-benzyl-5-(2-ethoxy-3-pyridyl)-1-isopropyl- pyrazolo[4,3-b]pyridin-7-amine::US11491140, Example 41 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 500 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=580432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=580432&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138746917 475726283 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1222983 CCOc1ncccc1-c1cc(NCc2cc(C)no2)c(NC(C)C)c(C=N)n1 InChI=1S/C21H26N6O2/c1-5-28-21-16(7-6-8-23-21)17-10-18(24-12-15-9-14(4)27-29-15)20(25-13(2)3)19(11-22)26-17/h6-11,13,22,25H,5,12H2,1-4H3,(H,24,26) QWJMKCBKZVIUAM-UHFFFAOYSA-N 580434 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(3- methylisoxazol-5-yljmethyl)pyrazolo[4,3- b]pyridin-7-amine::US11491140, Example 42 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 82.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=580434 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=580434&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138746923 475726285 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1222986 CCOc1ncccc1-c1cc(NCc2noc(C)n2)c(NC(C)C)c(C=N)n1 InChI=1S/C20H25N7O2/c1-5-28-20-14(7-6-8-22-20)15-9-16(23-11-18-25-13(4)29-27-18)19(24-12(2)3)17(10-21)26-15/h6-10,12,21,24H,5,11H2,1-4H3,(H,23,26) WXGZVKRAYFNMHG-UHFFFAOYSA-N 580435 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(5- methyl-1,2,4-oxadiazol-3- yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US11491140, Example 43 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 30.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=580435 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=580435&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138746921 475726286 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1222989 CCOc1ncccc1-c1cc(NCc2cc(C)n(C)n2)c(NC(C)C)c(C=N)n1 InChI=1S/C22H29N7O/c1-6-30-22-17(8-7-9-24-22)18-11-19(21(26-14(2)3)20(12-23)27-18)25-13-16-10-15(4)29(5)28-16/h7-12,14,23,26H,6,13H2,1-5H3,(H,25,27) XOLCNKIFKJXEDO-UHFFFAOYSA-N 580436 N-[(1,5-dimethylpyrazol-3-yl)methyl]-5-(2- ethoxy-3-pyridyl)-1-isopropyl-pyrazolo[4,3- b]pyridin-7-amine::US11491140, Example 44 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 19.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=580436 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=580436&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138746919 475726287 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1222992 CCOc1ncccc1-c1cc(NCc2ccc(=O)n(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(8-7-11-25-24)19-12-20(26-13-17-9-10-21(31)29(5)14-17)23-22(27-19)16(4)28-30(23)15(2)3/h7-12,14-15H,6,13H2,1-5H3,(H,26,27) IFSZKCSGKSFXTM-UHFFFAOYSA-N 279015 3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4-yl)methyl)amino)-1H-pyrazolo[4,3-b]pyridin-5-yl)-1-methylpyridin-2(1H)-one::US10034861, Example 45::US10512632, Example 45::US10806718, Example 45::US11026923, Example 45::US11491140, Example 45::US11634416, Example 45 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.00 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279015 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279015&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273343 378160604 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1222995 CCOc1ncccc1-c1cc(NCc2c[nH]c(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H27N7O/c1-6-30-22-17(8-7-9-23-22)18-10-19(25-12-16-11-24-15(5)26-16)21-20(27-18)14(4)28-29(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,24,26)(H,25,27) OESORFJHOJQXKR-UHFFFAOYSA-N 279016 5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((2-methyl-1H-imidazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 46::US10512632, Example 46::US10766893, Example S46::US10806718, Example 46::US11026923, Example 46::US11491140, Example 46::US11634416, Example 46 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 5.00 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279016&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273345 378160605 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1222998 CCOc1ncccc1-c1cc(NCc2cc(C)[nH]n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H27N7O/c1-6-30-22-17(8-7-9-23-22)18-11-19(24-12-16-10-14(4)26-27-16)21-20(25-18)15(5)28-29(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,24,25)(H,26,27) BKIZQOUWXXJIIE-UHFFFAOYSA-N 279017 5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((5-methyl-1H-pyrazol-3-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 47::US10512632, Example 47::US10766893, Example S54::US10806718, Example 47::US11026923, Example 47::US11491140, Example 47::US11634416, Example 47 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.60 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279017&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273346 378160606 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223001 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(CC)nc(C)c2n1 InChI=1S/C21H25N7O/c1-5-28-20-18(23-11-15-12-24-27(4)13-15)10-17(25-19(20)14(3)26-28)16-8-7-9-22-21(16)29-6-2/h7-10,12-13H,5-6,11H2,1-4H3,(H,23,25) ALQSQGPOANFHOP-UHFFFAOYSA-N 279018 5-(2-ethoxypyridin-3-yl)-1-ethyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 48::US10512632, Example 48::US10618913, Example S48::US10766893, Example S48::US10806718, Example 48::US11026923, Example 48::US11491140, Example 48::US11634416, Example 48 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 38.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279018&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273347 378160607 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223004 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1cccn(C)c1=O InChI=1S/C21H25N7O/c1-13(2)28-20-18(22-10-15-11-23-27(5)12-15)9-17(24-19(20)14(3)25-28)16-7-6-8-26(4)21(16)29/h6-9,11-13H,10H2,1-5H3,(H,22,24) MRQVRXHGMURIIP-UHFFFAOYSA-N 279019 3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4-yl)methyl)amino)-1H-pyrazolo[4,3-b]pyridin-5-yl)-1-methylpyridin-2(1H)-one::US10034861, Example 49::US10512632, Example 49::US10766893, Example S49::US10806718, Example 49::US11026923, Example 49::US11491140, Example 49::US11634416, Example 49 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 170 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279019 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279019&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273348 378160608 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223007 CCOc1ncccc1-c1cc(NCc2nc(C)co2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6O2/c1-6-29-22-16(8-7-9-23-22)17-10-18(24-11-19-25-14(4)12-30-19)21-20(26-17)15(5)27-28(21)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,24,26) LWOWQQZYEXAZTD-UHFFFAOYSA-N 279020 5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((4-methyloxazol-2-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine 2,2,2-trifluoroacetate::US10034861, Example 50::US10512632, Example 50::US10766893, Example S50::US10806718, Example 50::US11026923, Example 50::US11491140, Example 50::US11634416, Example 50 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 9.00 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279020 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279020&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273350 378160609 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223010 CCOc1ncccc1-c1cc(NCc2cn(C)c(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H29N7O/c1-7-31-23-18(9-8-10-24-23)19-11-20(25-12-17-13-29(6)16(5)26-17)22-21(27-19)15(4)28-30(22)14(2)3/h8-11,13-14H,7,12H2,1-6H3,(H,25,27) RIBLUNUCLUPFGL-UHFFFAOYSA-N 279021 N-((1,2-dimethyl-1H-imidazol-4-yl)methyl)-5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-1H-pyrazolo[4,3-b]pyridin-7-amine 2,2,2-trifluoroacetate::US10034861, Example 51::US10512632, Example 51::US10766893, Example S51::US10806718, Example 51::US11026923, Example 51::US11491140, Example 51::US11634416, Example 51 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 53.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279021 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279021&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273354 378160610 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223013 CCOc1ncccc1-c1cc(NCc2noc(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H25N7O2/c1-6-29-21-15(8-7-9-22-21)16-10-17(23-11-18-24-14(5)30-27-18)20-19(25-16)13(4)26-28(20)12(2)3/h7-10,12H,6,11H2,1-5H3,(H,23,25) GALBTAGDVOLYTK-UHFFFAOYSA-N 279022 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 52::US10512632, Example 52::US10766893, Example S52::US10806718, Example 52::US11026923, Example 52::US11491140, Example 52 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.90 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279022 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279022&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273351 378160611 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223016 CCOc1ncccc1-c1cc(NCc2ncon2)c2n(nc(C)c2n1)C(C)C InChI=1S/C20H23N7O2/c1-5-28-20-14(7-6-8-21-20)15-9-16(22-10-17-23-11-29-26-17)19-18(24-15)13(4)25-27(19)12(2)3/h6-9,11-12H,5,10H2,1-4H3,(H,22,24) HUAHNRHWFFYRAT-UHFFFAOYSA-N 279023 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1,2,4-oxadiazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 53::US10512632, Example 53::US10766893, Example S53::US10806718, Example 53::US11026923, Example 53::US11491140, Example 53::US11634416, Example 53 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 9.30 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279023&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273357 378160612 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223019 CCOc1ncccc1-c1cc(NCc2cc(C)n(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H29N7O/c1-7-31-23-18(9-8-10-24-23)19-12-20(25-13-17-11-15(4)29(6)28-17)22-21(26-19)16(5)27-30(22)14(2)3/h8-12,14H,7,13H2,1-6H3,(H,25,26) LOSBPLVFUGTAOA-UHFFFAOYSA-N 279024 N-[(1,5-dimethylpyrazol-3-yl)methyl]-5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 54::US10512632, Example 54::US10806718, Example 54::US11026923, Example 54::US11491140, Example 54::US11634416, Example 54 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.390 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279024 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279024&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273352 378160613 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223022 CCOc1ncccc1-c1cc(NCc2n[nH]c(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-6-30-21-15(8-7-9-22-21)16-10-17(23-11-18-24-14(5)26-27-18)20-19(25-16)13(4)28-29(20)12(2)3/h7-10,12H,6,11H2,1-5H3,(H,23,25)(H,24,26,27) QVFBWQCMGPADBC-UHFFFAOYSA-N 279025 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methyl-1H-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 55::US10512632, Example 55::US10766893, Example S55::US10806718, Example 55::US11026923, Example 55::US11491140, Example 55::US11634416, Example 55 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 3.40 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279025&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273353 378160614 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223025 CCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(ncc2n1)C(C)C InChI=1S/C20H24N8O/c1-5-29-20-14(7-6-8-21-20)15-9-16(22-11-18-23-12-27(4)26-18)19-17(25-15)10-24-28(19)13(2)3/h6-10,12-13H,5,11H2,1-4H3,(H,22,25) LBAWYUCYPDZBSF-UHFFFAOYSA-N 279026 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 56::US10512632, Example 56::US10766893, Example S56::US10806718, Example 56::US11026923, Example 56::US11491140, Example 56::US11634416, Example 56 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 16.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279026&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273358 378160615 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223028 CCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(ncc2n1)C(C)C InChI=1S/C20H23N7O/c1-4-28-20-15(6-5-8-21-20)16-10-17(22-11-14-7-9-23-26-14)19-18(25-16)12-24-27(19)13(2)3/h5-10,12-13H,4,11H2,1-3H3,(H,22,25)(H,23,26) RZEYZCLEVMBHDS-UHFFFAOYSA-N 279027 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 57::US10512632, Example 57::US10766893, Example S57::US10806718, Example 57::US11026923, Example 57::US11491140, Example 57::US11634416, Example 57 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 98.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279027&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273355 378160616 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223031 CCOc1ncccc1-c1cc(NCc2cn(C)cn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H27N7O/c1-6-30-22-17(8-7-9-23-22)18-10-19(24-11-16-12-28(5)13-25-16)21-20(26-18)15(4)27-29(21)14(2)3/h7-10,12-14H,6,11H2,1-5H3,(H,24,26) LRTCNZDFQQIFPH-UHFFFAOYSA-N 279028 5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((1-methyl-1H-imidazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine 2,2,2-trifluoroacetate::US10034861, Example 58::US10512632, Example 58::US10766893, Example S58::US10806718, Example 58::US11026923, Example 58::US11491140, Example 58::US11634416, Example 58 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.10 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279028&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273360 378160617 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223034 CCOc1ncccc1-c1cc(NCc2nnco2)c2n(nc(C)c2n1)C(C)C InChI=1S/C20H23N7O2/c1-5-28-20-14(7-6-8-21-20)15-9-16(22-10-17-25-23-11-29-17)19-18(24-15)13(4)26-27(19)12(2)3/h6-9,11-12H,5,10H2,1-4H3,(H,22,24) AHFKEZBAZQXEDY-UHFFFAOYSA-N 279029 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1,3,4-oxadiazol-2-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 59::US10512632, Example 59::US10766893, Example S59::US10806718, Example 59::US11026923, Example 59::US11491140, Example 59::US11634416, Example 59 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 55.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279029&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273356 378160618 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223037 CCOc1ncccc1-c1cc(NCc2ccn(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H27N7O/c1-6-30-22-17(8-7-10-23-22)18-12-19(24-13-16-9-11-28(5)27-16)21-20(25-18)15(4)26-29(21)14(2)3/h7-12,14H,6,13H2,1-5H3,(H,24,25) FXMRNOZDEMMBMY-UHFFFAOYSA-N 279030 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(1-methylpyrazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 60::US10512632, Example 60::US10766893, Example S60::US10806718, Example 60::US11491140, Example 60::US11634416, Example 60 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 6.50 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279030&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273369 378160619 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223040 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1cn(C)nc1C InChI=1S/C20H26N8/c1-12(2)28-20-18(21-8-15-9-22-26(5)10-15)7-17(23-19(20)14(4)25-28)16-11-27(6)24-13(16)3/h7,9-12H,8H2,1-6H3,(H,21,23) SZOKENQFAYLAJE-UHFFFAOYSA-N 279031 5-(1,3-dimethylpyrazol-4-yl)-1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 61::US10512632, Example 61::US10618913, Example S61::US10766893, Example S61::US10806718, Example 61::US11491140, Example 61::US11634416, Example 61 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 550 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279031&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273370 378160620 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223043 COc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H25N7O/c1-13(2)28-20-18(23-10-15-11-24-27(4)12-15)9-17(25-19(20)14(3)26-28)16-7-6-8-22-21(16)29-5/h6-9,11-13H,10H2,1-5H3,(H,23,25) NDQZTZXQHDYXCS-UHFFFAOYSA-N 279032 1-isopropyl-5-(2-methoxy-3-pyridyl)-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 62::US10512632, Example 62::US10766893, Example S62::US10806718, Example 62::US11491140, Example 62::US11634416, Example 62 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 16.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279032&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273362 378160621 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223046 COc1ccccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6O/c1-14(2)28-22-19(23-11-16-12-24-27(4)13-16)10-18(25-21(22)15(3)26-28)17-8-6-7-9-20(17)29-5/h6-10,12-14H,11H2,1-5H3,(H,23,25) KTDTYSKLFCIVHF-UHFFFAOYSA-N 279033 1-isopropyl-5-(2-methoxyphenyl)-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 63::US10512632, Example 63::US10766893, Example S63::US10806718, Example 63::US11491140, Example 63::US11634416, Example 63 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 64.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279033&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273359 378160622 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223049 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1ccccc1 InChI=1S/C21H24N6/c1-14(2)27-21-19(22-11-16-12-23-26(4)13-16)10-18(17-8-6-5-7-9-17)24-20(21)15(3)25-27/h5-10,12-14H,11H2,1-4H3,(H,22,24) JFQFIBIPASGZMG-UHFFFAOYSA-N 279034 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-phenyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 64::US10512632, Example 64::US10766893, Example S64::US10806718, Example 64::US11491140, Example 64::US11634416, Example 64 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 52.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279034&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273365 378160623 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223052 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1ccsc1C InChI=1S/C20H24N6S/c1-12(2)26-20-18(21-9-15-10-22-25(5)11-15)8-17(16-6-7-27-14(16)4)23-19(20)13(3)24-26/h6-8,10-12H,9H2,1-5H3,(H,21,23) OOGMCENLMFETDO-UHFFFAOYSA-N 279035 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-(2-methyl-3-thienyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 65::US10512632, Example 65::US10766893, Example S65::US10806718, Example 65::US11491140, Example 65::US11634416, Example 65 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 7.90 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279035&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273363 378160624 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223055 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1cnn(C)c1C InChI=1S/C20H26N8/c1-12(2)28-20-18(21-8-15-9-22-26(5)11-15)7-17(24-19(20)13(3)25-28)16-10-23-27(6)14(16)4/h7,9-12H,8H2,1-6H3,(H,21,24) IOBLPVSVJNVETM-UHFFFAOYSA-N 279036 5-(1,5-dimethylpyrazol-4-yl)-1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 66::US10512632, Example 66::US10766893, Example S66::US10806718, Example 66::US11491140, Example 66::US11634416, Example 66 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 210 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279036&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273361 378160625 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223058 CCOc1ncccc1-c1cc(NCc2ccn(C)n2)c2n(nc(C)c2n1)[C@@H](C)CC InChI=1S/C23H29N7O/c1-6-15(3)30-22-20(25-14-17-10-12-29(5)28-17)13-19(26-21(22)16(4)27-30)18-9-8-11-24-23(18)31-7-2/h8-13,15H,6-7,14H2,1-5H3,(H,25,26)/t15-/m0/s1 GUZUXYPWYDLGJF-HNNXBMFYSA-N 580474 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1- methylpropyl]-N-[(1-methylpyrazol-3- yl)methyl]pyrazolo[4,3-b]pyridin-7-amine, enantiomer 2::US11491140, Example 67 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 9.60 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=580474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=580474&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 140830743 475726321 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223061 CCCOc1ncccc1-c1cc(NCc2nnn(C)n2)c2n(nc(C)c2n1)[C@@H](C)CC InChI=1S/C22H29N9O/c1-6-11-32-22-16(9-8-10-23-22)17-12-18(24-13-19-26-29-30(5)28-19)21-20(25-17)15(4)27-31(21)14(3)7-2/h8-10,12,14H,6-7,11,13H2,1-5H3,(H,24,25)/t14-/m0/s1 DGDYHVXCROBNNK-AWEZNQCLSA-N 580475 3-methyl-1-[1-methylpropyl]-N-[(2- methyltetrazol-5-yl)methyl]-5-(2-propoxy-3- pyridyl)pyrazolo[4,3-b]pyridin-7-amine, enantiomer 2::US11491140, Example 68 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.790 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=580475 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=580475&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138522158 475726322 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223064 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(ncc2n1)[C@@H](C)CC InChI=1S/C22H27N7O/c1-5-15(3)29-21-19(24-11-16-12-25-28(4)14-16)10-18(27-20(21)13-26-29)17-8-7-9-23-22(17)30-6-2/h7-10,12-15H,5-6,11H2,1-4H3,(H,24,27)/t15-/m0/s1 PNGBBNJWUZFNIY-HNNXBMFYSA-N 580476 5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N- [(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3- b]pyridin-7-amine, enantiomer 1::US11491140, Example 69 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 14.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=580476 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=580476&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 140830758 475726323 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223067 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(ncc2n1)[C@H](C)CC InChI=1S/C22H27N7O/c1-5-15(3)29-21-19(24-11-16-12-25-28(4)14-16)10-18(27-20(21)13-26-29)17-8-7-9-23-22(17)30-6-2/h7-10,12-15H,5-6,11H2,1-4H3,(H,24,27)/t15-/m1/s1 PNGBBNJWUZFNIY-OAHLLOKOSA-N 580477 5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N- [(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3- b]pyridin-7-amine, enantiomer 2::US11491140, Example 70 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 140 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=580477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=580477&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 140830750 475726324 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223070 CCOc1ncccc1-c1cc(NCc2scnc2C)c2n(ncc2n1)C(C)C InChI=1S/C21H24N6OS/c1-5-28-21-15(7-6-8-22-21)16-9-17(23-11-19-14(4)24-12-29-19)20-18(26-16)10-25-27(20)13(2)3/h6-10,12-13H,5,11H2,1-4H3,(H,23,26) CKGZFAMXPLRINR-UHFFFAOYSA-N 424981 US10512632, Example 71::US10766893, Example S71::US10806718, Example 71::US11026923, Example 71::US11491140, Example 71::US11634416, Example 71 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 170 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=424981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=424981&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138536011 434150492 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223073 CCOc1ncccc1-c1cc(OCc2cnc(C)o2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H25N5O3/c1-6-28-22-17(8-7-9-23-22)18-10-19(29-12-16-11-24-15(5)30-16)21-20(25-18)14(4)26-27(21)13(2)3/h7-11,13H,6,12H2,1-5H3 PFDYAXRVKURLCH-UHFFFAOYSA-N 279042 5-[[5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-yl]oxymethyl]-2-methyl-oxazole::US10034861, Example 72::US10512632, Example 72::US10766893, Example S72::US10806718, Example 72::US11491140, Example 72::US11634416, Example 72 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 14.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279042&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273372 378160630 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223076 CCOc1ncccc1-c1cc(NCc2ccncn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H25N7O/c1-5-30-22-17(7-6-9-24-22)18-11-19(25-12-16-8-10-23-13-26-16)21-20(27-18)15(4)28-29(21)14(2)3/h6-11,13-14H,5,12H2,1-4H3,(H,25,27) UIVWJGFOIVSSOG-UHFFFAOYSA-N 279043 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(pyrimidin-4-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 73::US10512632, Example 73::US10766893, Example S73::US10806718, Example 73::US11491140, Example 73::US11634416, Example 73 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 81.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279043&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273379 378160631 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223079 CCOc1ncccc1-c1cc(NCc2ncccn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H25N7O/c1-5-30-22-16(8-6-9-25-22)17-12-18(26-13-19-23-10-7-11-24-19)21-20(27-17)15(4)28-29(21)14(2)3/h6-12,14H,5,13H2,1-4H3,(H,26,27) DFFZMDINLLNNPV-UHFFFAOYSA-N 279044 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(pyrimidin-2-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 74::US10512632, Example 74::US10766893, Example S74::US10806718, Example 74::US11491140, Example 74::US11634416, Example 74 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.10 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279044&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273368 378160632 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223082 CCOc1ncccc1-c1cc(NCc2nccc(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O/c1-6-31-23-17(8-7-10-25-23)18-12-19(26-13-20-24-11-9-15(4)27-20)22-21(28-18)16(5)29-30(22)14(2)3/h7-12,14H,6,13H2,1-5H3,(H,26,28) ZCARSOPJYGJCRQ-UHFFFAOYSA-N 279045 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(4-methylpyrimidin-2-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 75::US10512632, Example 75::US10806718, Example 75::US11026923, Example 75::US11491140, Example 75::US11634416, Example 75 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 9.90 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279045&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273374 378160633 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223085 CCOc1ncccc1-c1cc(NCc2cnccn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H25N7O/c1-5-30-22-17(7-6-8-25-22)18-11-19(26-13-16-12-23-9-10-24-16)21-20(27-18)15(4)28-29(21)14(2)3/h6-12,14H,5,13H2,1-4H3,(H,26,27) DTEHKURDWHCADV-UHFFFAOYSA-N 279046 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(pyrazin-2-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 76::US10512632, Example 76::US10766893, Example S76::US10806718, Example 76::US11026923, Example 76::US11491140, Example 76::US11634416, Example 76 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 23.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279046&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273373 378160634 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223088 CCOc1ncccc1-c1cc(NCc2cccnc2C(F)(F)F)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H25F3N6O/c1-5-34-23-17(9-7-11-29-23)18-12-19(21-20(31-18)15(4)32-33(21)14(2)3)30-13-16-8-6-10-28-22(16)24(25,26)27/h6-12,14H,5,13H2,1-4H3,(H,30,31) TZBBGNNWRKPAEH-UHFFFAOYSA-N 279047 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[2-(trifluoromethyl)-3-pyridyl]methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 77::US10512632, Example 77::US10766893, Example S77::US10806718, Example 77::US11026923, Example 77::US11491140, Example 77::US11634416, Example 77 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 21.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279047&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273376 378160635 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223091 CCOc1ncccc1-c1cc(NCc2ccn(C)c(=O)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(8-7-10-25-24)19-13-20(26-14-17-9-11-29(5)21(31)12-17)23-22(27-19)16(4)28-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,26,27) IBAWDCALOOJODQ-UHFFFAOYSA-N 279048 4-[[[5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-yl]amino]methyl]-1-methyl-pyridin-2-one::US10034861, Example 78::US10512632, Example 78::US10766893, Example S78::US10806718, Example 78::US11026923, Example 78::US11491140, Example 78::US11634416, Example 78 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 27.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279048&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273377 378160636 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223094 CCNc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H28N8/c1-6-23-22-17(8-7-9-24-22)18-10-19(25-11-16-12-26-29(5)13-16)21-20(27-18)15(4)28-30(21)14(2)3/h7-10,12-14H,6,11H2,1-5H3,(H,23,24)(H,25,27) ZEUKRJZWWLBXIK-UHFFFAOYSA-N 279049 5-(2-(ethylamino)pyridin-3-yl)-1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 79::US10512632, Example 79::US10766893, Example S79::US10806718, Example 79::US11026923, Example 79::US11491140, Example 79::US11634416, Example 79 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 230 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279049&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273375 378160637 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223097 CCOc1ncccc1-c1cc(NCc2cc(OC)ccn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-19(8-7-10-26-24)20-13-21(27-14-17-12-18(31-5)9-11-25-17)23-22(28-20)16(4)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) BVKDBZHCRMPMSA-UHFFFAOYSA-N 279050 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(4-methoxy-2-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 81::US10512632, Example 81::US10766893, Example S81::US10806718, Example 81::US11026923, Example 81::US11491140, Example 81::US11634416, Example 81 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.000 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279050&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273378 378160638 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223100 CCOc1ncccc1-c1cc(NCc2cncc(OC)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O2/c1-6-32-23-17(8-7-9-25-23)18-10-19(26-12-16-11-24-13-20(27-16)31-5)22-21(28-18)15(4)29-30(22)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,26,28) OSHMEGNKNUJDSU-UHFFFAOYSA-N 279051 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(6-methoxypyrazin-2-yl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 82::US10512632, Example 82::US10766893, Example S82::US10806718, Example 82::US11026923, Example 82::US11491140, Example 82::US11634416, Example 82 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 16.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279051&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273380 378160639 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223103 CCOc1ncccc1-c1cc(NCc2ncc(F)cn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H24FN7O/c1-5-31-22-16(7-6-8-24-22)17-9-18(25-12-19-26-10-15(23)11-27-19)21-20(28-17)14(4)29-30(21)13(2)3/h6-11,13H,5,12H2,1-4H3,(H,25,28) ZIOQYWFVMVDZRK-UHFFFAOYSA-N 279052 5-(2-ethoxy-3-pyridyl)-N-[(5-fluoropyrimidin-2-yl)methyl]-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 83::US10512632, Example 83::US10766893, Example S83::US10806718, Example 83::US11026923, Example 83::US11491140, Example 83::US11634416, Example 83 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 17.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279052&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273381 378160640 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223106 CCOc1ncccc1-c1cc(NCc2cccnc2C)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O/c1-6-31-24-19(10-8-12-26-24)20-13-21(27-14-18-9-7-11-25-16(18)4)23-22(28-20)17(5)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) JOFWPJKNNJOGJF-UHFFFAOYSA-N 279053 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methyl-3-pyridyl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 84::US10512632, Example 84::US10766893, Example S84::US10806718, Example 84::US11026923, Example 84::US11491140, Example 84::US11634416, Example 84 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 19.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279053&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273382 378160641 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223109 CCOc1ncccc1-c1cc(NCc2cccnc2F)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H25FN6O/c1-5-31-23-17(9-7-11-26-23)18-12-19(27-13-16-8-6-10-25-22(16)24)21-20(28-18)15(4)29-30(21)14(2)3/h6-12,14H,5,13H2,1-4H3,(H,27,28) JJLMBZVLDAMDGO-UHFFFAOYSA-N 279054 5-(2-ethoxy-3-pyridyl)-N-[(2-fluoro-3-pyridyl)methyl]-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 85::US10512632, Example 85::US10766893, Example S85::US10806718, Example 85::US11026923, Example 85::US11491140, Example 85::US11634416, Example 85 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.40 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279054&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273384 378160642 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223112 CCOc1ncccc1-c1cc(NCc2cccnc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(10-8-12-26-24)19-13-20(27-14-17-9-7-11-25-23(17)31-5)22-21(28-19)16(4)29-30(22)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) LOZUTDKVJLMDTB-UHFFFAOYSA-N 279055 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 172::US10034861, Example 180::US10034861, Example 181::US10034861, Example 182::US10034861, Example 86::US10512632, Example 86::US10766893, Example S86::US10806718, Example 182::US11026923, Example 182::US11491140, Example 86::US11634416, Example 86 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 20.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279055&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273386 378160643 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223115 CCOc1ncccc1-c1cc(NCc2ccc(C)nc2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O/c1-6-31-24-19(8-7-11-25-24)20-12-21(27-14-18-10-9-16(4)26-13-18)23-22(28-20)17(5)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) VEZPCNBBBMUATR-UHFFFAOYSA-N 279056 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(6-methyl-3-pyridyl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 87::US10512632, Example 87::US10766893, Example S87::US10806718, Example 87::US11026923, Example 87::US11491140, Example 87::US11634416, Example 87 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 6.30 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279056 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279056&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273383 378160644 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223118 CCOc1ncccc1-c1cc(NCc2ccccc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C25H29N5O2/c1-6-32-25-19(11-9-13-26-25)20-14-21(27-15-18-10-7-8-12-22(18)31-5)24-23(28-20)17(4)29-30(24)16(2)3/h7-14,16H,6,15H2,1-5H3,(H,27,28) IXQRCVAKBIMUJN-UHFFFAOYSA-N 279057 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxyphenyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 88::US10512632, Example 88::US10766893, Example S88::US10806718, Example 88::US11026923, Example 88::US11491140, Example 88::US11634416, Example 88 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 110 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279057&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273385 378160645 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223121 CCOc1ncccc1-c1cc(NCc2ccccc2F)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H26FN5O/c1-5-31-24-18(10-8-12-26-24)20-13-21(27-14-17-9-6-7-11-19(17)25)23-22(28-20)16(4)29-30(23)15(2)3/h6-13,15H,5,14H2,1-4H3,(H,27,28) PBVAXRZBSWSQNU-UHFFFAOYSA-N 279058 5-(2-ethoxy-3-pyridyl)-N-[(2-fluorophenyl)methyl]-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 89::US10512632, Example 89::US10766893, Example S89::US10806718, Example 89::US11026923, Example 89::US11491140, Example 89::US11634416, Example 89 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 61.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279058&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273388 378160646 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223124 CCOc1ncccc1-c1cc(NCc2ccccc2C(F)(F)F)c2n(nc(C)c2n1)C(C)C InChI=1S/C25H26F3N5O/c1-5-34-24-18(10-8-12-29-24)20-13-21(23-22(31-20)16(4)32-33(23)15(2)3)30-14-17-9-6-7-11-19(17)25(26,27)28/h6-13,15H,5,14H2,1-4H3,(H,30,31) XUHWSBHEGYQEDI-UHFFFAOYSA-N 279059 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[2-(trifluoromethyl)phenyl]methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 90::US10512632, Example 90::US10766893, Example S90::US10806718, Example 90::US11026923, Example 90::US11491140, Example 90::US11634416, Example 90 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 270 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279059&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273387 378160647 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223127 CCOc1ncccc1-c1cc(NCc2nccnc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O2/c1-6-32-22-16(8-7-9-25-22)17-12-18(27-13-19-23(31-5)26-11-10-24-19)21-20(28-17)15(4)29-30(21)14(2)3/h7-12,14H,6,13H2,1-5H3,(H,27,28) GJZNHSHBNVLOAO-UHFFFAOYSA-N 279060 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(3-methoxypyrazin-2-yl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 91::US10512632, Example 91::US10766893, Example S91::US10806718, Example 91::US11026923, Example 91::US11491140, Example 91::US11634416, Example 91 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 27.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279060&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273389 378160648 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223130 CCOc1ncccc1-c1cc(NCc2cnccc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(8-7-10-26-24)19-12-20(27-14-17-13-25-11-9-21(17)31-5)23-22(28-19)16(4)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) BHINMZMKXRIBEG-UHFFFAOYSA-N 279061 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(4-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 92::US10512632, Example 92::US10766893, Example S92::US10806718, Example 92::US11026923, Example 92::US11491140, Example 92::US11634416, Example 92 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 47.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279061&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273390 378160649 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223133 CCCOc1ncccc1-c1cc(NCc2nnn(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H27N9O/c1-6-10-31-21-15(8-7-9-22-21)16-11-17(23-12-18-25-28-29(5)27-18)20-19(24-16)14(4)26-30(20)13(2)3/h7-9,11,13H,6,10,12H2,1-5H3,(H,23,24) IEZRRRCALKIRBN-UHFFFAOYSA-N 279062 1-isopropyl-3-methyl-N-[(2-methyltetrazol-5-yl)methyl]-5-(2-propoxy-3-pyridyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 93::US10512632, Example 93::US10766893, Example S93::US10806718, Example 93::US11026923, Example 93::US11491140, Example 93::US11634416, Example 93 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4.30 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279062&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273393 378160650 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223136 CCCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H29N7O/c1-6-10-31-23-18(8-7-9-24-23)19-11-20(25-12-17-13-26-29(5)14-17)22-21(27-19)16(4)28-30(22)15(2)3/h7-9,11,13-15H,6,10,12H2,1-5H3,(H,25,27) JYRPZCKZXZYAOY-UHFFFAOYSA-N 279063 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-(2-propoxy-3-pyridyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 94::US10512632, Example 94::US10766893, Example S94::US10806718, Example 94::US11026923, Example 94::US11491140, Example 94::US11634416, Example 94 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.40 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279063&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273391 378160651 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223139 COc1ncccc1CNc1cc(nc2c(C)nn(C(C)C)c12)-c1cccnc1OC InChI=1S/C23H26N6O2/c1-14(2)29-21-19(26-13-16-8-6-10-24-22(16)30-4)12-18(27-20(21)15(3)28-29)17-9-7-11-25-23(17)31-5/h6-12,14H,13H2,1-5H3,(H,26,27) YPNDBZHHIYJRNN-UHFFFAOYSA-N 279064 1-isopropyl-5-(2-methoxy-3-pyridyl)-N-[(2-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 95::US10512632, Example 95::US10766893, Example S95::US10806718, Example 95::US11026923, Example 95::US11491140, Example 95::US11634416, Example 95 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 42.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279064 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279064&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273392 378160652 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223142 COc1ccc(CNc2cc(nc3c(C)nn(C(C)C)c23)-c2cccnc2OC)cn1 InChI=1S/C23H26N6O2/c1-14(2)29-22-19(25-12-16-8-9-20(30-4)26-13-16)11-18(27-21(22)15(3)28-29)17-7-6-10-24-23(17)31-5/h6-11,13-14H,12H2,1-5H3,(H,25,27) HUQJJAUBVULGLS-UHFFFAOYSA-N 279065 1-isopropyl-5-(2-methoxy-3-pyridyl)-N-[(6-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 96::US10512632, Example 96::US10766893, Example S96::US10806718, Example 96::US11026923, Example 96::US11491140, Example 96::US11634416, Example 96 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 18.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279065&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273394 378160653 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223145 CC(C)Oc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H29N7O/c1-14(2)30-22-20(25-11-17-12-26-29(6)13-17)10-19(27-21(22)16(5)28-30)18-8-7-9-24-23(18)31-15(3)4/h7-10,12-15H,11H2,1-6H3,(H,25,27) IWDHUHWZRSHWGD-UHFFFAOYSA-N 279066 5-(2-isopropoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 97::US10512632, Example 97::US10766893, Example S97::US10806718, Example 97::US11026923, Example 97::US11491140, Example 97::US11634416, Example 97 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.40 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279066&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273395 378160654 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223148 CCOc1ncccc1-c1cc(NCc2nc[nH]n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C20H24N8O/c1-5-29-20-14(7-6-8-21-20)15-9-16(22-10-17-23-11-24-26-17)19-18(25-15)13(4)27-28(19)12(2)3/h6-9,11-12H,5,10H2,1-4H3,(H,22,25)(H,23,24,26) ZUZXEJWHRNAFBA-UHFFFAOYSA-N 279067 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1H-1,2,4-triazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 98::US10512632, Example 98::US10766893, Example S98::US10806718, Example 98::US11491140, Example 98::US11634416, Example 98 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 7.20 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279067 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279067&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273396 378160655 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223151 CCOc1ncccc1-c1cc(NCc2nn[nH]n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C19H23N9O/c1-5-29-19-13(7-6-8-20-19)14-9-15(21-10-16-23-26-27-24-16)18-17(22-14)12(4)25-28(18)11(2)3/h6-9,11H,5,10H2,1-4H3,(H,21,22)(H,23,24,26,27) DBRGOFPEANLZGU-UHFFFAOYSA-N 279068 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(2H-tetrazol-5-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 99::US10512632, Example 99::US10766893, Example S99::US10806718, Example 99::US11026923, Example 99::US11491140, Example 99::US11634416, Example 99 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.730 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279068&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273399 378160656 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223154 CCOc1ncccc1-c1cc(NCc2ccccn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H26N6O/c1-5-30-23-18(10-8-12-25-23)19-13-20(26-14-17-9-6-7-11-24-17)22-21(27-19)16(4)28-29(22)15(2)3/h6-13,15H,5,14H2,1-4H3,(H,26,27) GWMDZOSIIBARTA-UHFFFAOYSA-N 279069 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(2-pyridylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 100::US10512632, Example 100::US10766893, Example S100::US10806718, Example 100::US11026923, Example 100::US11491140, Example 100::US11634416, Example 100 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 6.30 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279069&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273397 378160657 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223157 CCOc1ncccc1-c1cc(NCc2cccc(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O/c1-6-31-24-19(11-8-12-25-24)20-13-21(26-14-18-10-7-9-16(4)27-18)23-22(28-20)17(5)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,26,28) HBRGVUVPCCNRAT-UHFFFAOYSA-N 279070 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(6-methyl-2-pyridyl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 101::US10512632, Example 101::US10766893, Example S101::US10806718, Example 101::US11026923, Example 101::US11491140, Example 101::US11634416, Example 101 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 20.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279070&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273398 378160658 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223160 CCOc1ncccc1-c1cc(NCc2cccc(OC)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(10-8-12-25-24)19-13-20(26-14-17-9-7-11-21(27-17)31-5)23-22(28-19)16(4)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,26,28) DHUHVCYRBUZRAT-UHFFFAOYSA-N 279071 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(6-methoxy-2-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 102::US10512632, Example 102::US10766893, Example S102::US10806718, Example 102::US11026923, Example 102::US11491140, Example 102::US11634416, Example 102 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.00 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279071&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273400 378160659 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223163 CCOc1ncccc1-c1cc(NCc2ccnc(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O/c1-6-31-24-19(8-7-10-26-24)20-13-21(27-14-18-9-11-25-16(4)12-18)23-22(28-20)17(5)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) MPJXQIBFZBPJFH-UHFFFAOYSA-N 279072 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methyl-4-pyridyl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 103::US10512632, Example 103::US10766893, Example S103::US10806718, Example 103::US11026923, Example 103::US11491140, Example 103::US11634416, Example 103 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 5.40 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279072&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273402 378160660 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223166 CCOc1ncccc1-c1cc(NCc2ccnc(OC)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(8-7-10-26-24)19-13-20(27-14-17-9-11-25-21(12-17)31-5)23-22(28-19)16(4)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) SJJQCULDRYOYED-UHFFFAOYSA-N 279073 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-4-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 104::US10512632, Example 104::US10766893, Example S104::US10806718, Example 104::US11026923, Example 104::US11491140, Example 104::US11634416, Example 104 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.20 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279073&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273401 378160661 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223169 CCOc1ncccc1-c1cc(NCc2ccnc(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O/c1-6-31-23-18(8-7-10-25-23)19-12-20(26-13-17-9-11-24-16(5)27-17)22-21(28-19)15(4)29-30(22)14(2)3/h7-12,14H,6,13H2,1-5H3,(H,26,28) OEGPBHHKEYGZCG-UHFFFAOYSA-N 279074 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methylpyrimidin-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 105::US10512632, Example 105::US10766893, Example S105::US10806718, Example 105::US11026923, Example 105::US11491140, Example 105::US11634416, Example 105 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 54.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279074&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273403 378160662 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223172 CCOc1ncccc1-c1cc(NCc2cncc(OC)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-19(8-7-9-26-24)20-11-21(27-13-17-10-18(31-5)14-25-12-17)23-22(28-20)16(4)29-30(23)15(2)3/h7-12,14-15H,6,13H2,1-5H3,(H,27,28) JCOKQWFPIMEUNS-UHFFFAOYSA-N 279075 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(5-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 106::US10512632, Example 106::US10766893, Example S106::US10806718, Example 106::US11026923, Example 106::US11491140, Example 106::US11634416, Example 106 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.10 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279075&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273404 378160663 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223175 CCOc1ncccc1-c1cc(NCc2cccc(n2)C(F)(F)F)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H25F3N6O/c1-5-34-23-17(9-7-11-28-23)18-12-19(22-21(31-18)15(4)32-33(22)14(2)3)29-13-16-8-6-10-20(30-16)24(25,26)27/h6-12,14H,5,13H2,1-4H3,(H,29,31) FVVVRFIRYVUVEI-UHFFFAOYSA-N 279076 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[6-(trifluoromethyl)-2-pyridyl]methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 107::US10512632, Example 107::US10766893, Example S107::US10806718, Example 107::US11026923, Example 107::US11491140, Example 107::US11634416, Example 107 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 110 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279076&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273405 378160664 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223178 CCOc1ncccc1-c1cc(NCc2cccn(C)c2=O)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-23-18(10-7-11-25-23)19-13-20(26-14-17-9-8-12-29(5)24(17)31)22-21(27-19)16(4)28-30(22)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,26,27) YLQLMBPUXKUVLD-UHFFFAOYSA-N 279077 3-[[[5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-yl]amino]methyl]-1-methyl-pyridin-2-one::US10034861, Example 108::US10512632, Example 108::US10766893, Example S108::US10806718, Example 108::US11026923, Example 108::US11491140, Example 108::US11634416, Example 108 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.80 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279077&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273406 378160665 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223181 CCOc1ncccc1-c1cc(NCc2cnn(CC)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H29N7O/c1-6-29-14-17(13-26-29)12-25-20-11-19(18-9-8-10-24-23(18)31-7-2)27-21-16(5)28-30(15(3)4)22(20)21/h8-11,13-15H,6-7,12H2,1-5H3,(H,25,27) IEORIQPBXNSJCP-UHFFFAOYSA-N 279078 5-(2-ethoxy-3-pyridyl)-N-[(1-ethylpyrazol-4-yl)methyl]-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 109::US10512632, Example 109::US10766893, Example S109::US10806718, Example 109::US11026923, Example 109::US11491140, Example 109::US11634416, Example 109 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4.90 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279078&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273407 378160666 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223184 CCCn1cc(CNc2cc(nc3c(C)nn(C(C)C)c23)-c2cccnc2OCC)cn1 InChI=1S/C24H31N7O/c1-6-11-30-15-18(14-27-30)13-26-21-12-20(19-9-8-10-25-24(19)32-7-2)28-22-17(5)29-31(16(3)4)23(21)22/h8-10,12,14-16H,6-7,11,13H2,1-5H3,(H,26,28) NPLKFZSTTQLUHS-UHFFFAOYSA-N 279079 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(1-propylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 110::US10512632, Example 110::US10766893, Example S110::US10806718, Example 110::US11026923, Example 110::US11491140, Example 110::US11634416, Example 110 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 11.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279079&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273408 378160667 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223187 CCOc1ncccc1-c1cc(NCc2ccc(OC)nc2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(8-7-11-25-24)19-12-20(26-13-17-9-10-21(31-5)27-14-17)23-22(28-19)16(4)29-30(23)15(2)3/h7-12,14-15H,6,13H2,1-5H3,(H,26,28) XMJAAWKICASNAA-UHFFFAOYSA-N 279080 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(6-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 111::US10512632, Example 111::US10766893, Example S111::US10806718, Example 111::US11026923, Example 111::US11491140, Example 111::US11634416, Example 111 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 28.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279080 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279080&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273409 378160668 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223190 CCOc1ncccc1-c1cc(NCc2ccc(OC)cn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-19(8-7-11-25-24)20-12-21(27-13-17-9-10-18(31-5)14-26-17)23-22(28-20)16(4)29-30(23)15(2)3/h7-12,14-15H,6,13H2,1-5H3,(H,27,28) HWSJSACIWPNYOB-UHFFFAOYSA-N 279081 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(5-methoxy-2-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 112::US10512632, Example 112::US10766893, Example S112::US10806718, Example 112::US11026923, Example 112::US11491140, Example 112::US11634416, Example 112 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 61.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279081&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273411 378160669 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223193 CCOc1ncccc1-c1cc(NCc2csc(C)n2)c2n(nc(C)c2n1)C1COC1 InChI=1S/C22H24N6O2S/c1-4-30-22-17(6-5-7-23-22)18-8-19(24-9-15-12-31-14(3)25-15)21-20(26-18)13(2)27-28(21)16-10-29-11-16/h5-8,12,16H,4,9-11H2,1-3H3,(H,24,26) BSSGJYYHYVLYMA-UHFFFAOYSA-N 279082 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(2-methylthiazol-4-yl)methyl]-1-(oxetan-3-yl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 113::US10512632, Example 113::US10618913, Example S113::US10766893, Example S113::US10806718, Example 113::US11026923, Example 113::US11491140, Example 113::US11634416, Example 113 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 110 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279082&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273410 378160670 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223196 CCOc1ncccc1-c1cc(NCc2cnc(OC)cn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O2/c1-6-32-23-17(8-7-9-24-23)18-10-19(26-11-16-12-27-20(31-5)13-25-16)22-21(28-18)15(4)29-30(22)14(2)3/h7-10,12-14H,6,11H2,1-5H3,(H,26,28) QIWVSVNHRDQBOW-UHFFFAOYSA-N 279083 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(5-methoxypyrazin-2-yl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 114::US10512632, Example 114::US10766893, Example S114::US10806718, Example 114::US11026923, Example 114::US11491140, Example 114::US11634416, Example 114 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 24.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279083 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279083&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273413 378160671 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223199 CCOc1ncccc1-c1cc(NCc2cccnc2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H26N6O/c1-5-30-23-18(9-7-11-25-23)19-12-20(26-14-17-8-6-10-24-13-17)22-21(27-19)16(4)28-29(22)15(2)3/h6-13,15H,5,14H2,1-4H3,(H,26,27) MYYHBCJMEYIHMC-UHFFFAOYSA-N 279084 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(3-pyridylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 115::US10512632, Example 115::US10766893, Example S115::US10806718, Example 115::US11026923, Example 115::US11491140, Example 115::US11634416, Example 115 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 15.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279084&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273412 378160672 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223202 CCOc1ncccc1-c1cc(NCc2ccc(F)nc2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H25FN6O/c1-5-31-23-17(7-6-10-25-23)18-11-19(26-12-16-8-9-20(24)27-13-16)22-21(28-18)15(4)29-30(22)14(2)3/h6-11,13-14H,5,12H2,1-4H3,(H,26,28) SKXWAYULKGVUDE-UHFFFAOYSA-N 279085 5-(2-ethoxy-3-pyridyl)-N-[(6-fluoro-3-pyridyl)methyl]-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 116::US10512632, Example 116::US10766893, Example S116::US10806718, Example 116::US11026923, Example 116::US11491140, Example 116::US11634416, Example 116 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 21.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279085&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273414 378160673 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223205 CCOc1ncccc1-c1cc(NCc2ccc(nc2)C(F)F)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H26F2N6O/c1-5-33-24-17(7-6-10-27-24)19-11-20(22-21(30-19)15(4)31-32(22)14(2)3)29-13-16-8-9-18(23(25)26)28-12-16/h6-12,14,23H,5,13H2,1-4H3,(H,29,30) FDEJYPFAUDLEJD-UHFFFAOYSA-N 279086 N-[[6-(difluoromethyl)-3-pyridyl]methyl]-5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 117::US10512632, Example 117::US10766893, Example S117::US10806718, Example 117::US11026923, Example 117::US11491140, Example 117::US11634416, Example 117 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 18.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279086&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273416 378160674 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223208 CCOc1ncccc1-c1cc(NCc2ncccc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-17(9-7-12-26-24)18-13-19(27-14-20-21(31-5)10-8-11-25-20)23-22(28-18)16(4)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) CQZGCHPJVLXYPV-UHFFFAOYSA-N 279087 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(3-methoxy-2-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 118::US10512632, Example 118::US10766893, Example S118::US10806718, Example 118::US11026923, Example 118::US11491140, Example 118::US11634416, Example 118 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 13.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279087&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273417 378160675 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223211 CCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(nc(C)c2n1)[C@H](C)CC 580541 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1- methylpropyl]-N-(1H-pyrazol-3- ylmethyl)pyrazolo[4,3-b]pyridin-7-amine, enantiomer 1::US11491140, Example 119 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 12.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=580541 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=580541&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 140830754 475726387 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223214 CCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(nc(C)c2n1)[C@@H](C)CC 580542 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1- methylpropyl]-N-(1H-pyrazol-3- ylmethyl)pyrazolo[4,3-b]pyridin-7-amine, enantiomer 2::US11491140, Example 120 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4.60 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=580542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=580542&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 140830699 475726388 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223217 CCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(nc(C)c2n1)[C@H](C)CC InChI=1S/C22H28N8O/c1-6-14(3)30-21-18(24-12-19-25-13-29(5)28-19)11-17(26-20(21)15(4)27-30)16-9-8-10-23-22(16)31-7-2/h8-11,13-14H,6-7,12H2,1-5H3,(H,24,26)/t14-/m1/s1 RANZHWURGHEKDD-CQSZACIVSA-N 580543 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1- methylpropyl]-N-[(1-methyl-1,2,4-triazol-3- yl)methyl]pyrazolo[4,3-b]pyridin-7-amine, enantiomer 1::US11491140, Example 121 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4.00 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=580543 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=580543&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 140830746 475726389 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223220 CCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(nc(C)c2n1)[C@@H](C)CC InChI=1S/C22H28N8O/c1-6-14(3)30-21-18(24-12-19-25-13-29(5)28-19)11-17(26-20(21)15(4)27-30)16-9-8-10-23-22(16)31-7-2/h8-11,13-14H,6-7,12H2,1-5H3,(H,24,26)/t14-/m0/s1 RANZHWURGHEKDD-AWEZNQCLSA-N 580547 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1- methylpropyl]-N-[(1-methyl-1,2,4-triazol-3- yl)methyl]pyrazolo[4,3-b]pyridin-7-amine, enantiomer 2::US11491140, Example 122 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.20 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=580547 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=580547&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 140830695 475726393 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1223223 CCOc1ncccc1-c1cc(NCc2nnc(C)o2)c2n(nc(C)c2n1)[C@@H](C)CC InChI=1S/C22H27N7O2/c1-6-13(3)29-21-18(24-12-19-27-26-15(5)31-19)11-17(25-20(21)14(4)28-29)16-9-8-10-23-22(16)30-7-2/h8-11,13H,6-7,12H2,1-5H3,(H,24,25)/t13-/m0/s1 SJDHGTJKQKPRAR-ZDUSSCGKSA-N 580548 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(5-methyl- 1,3,4-oxadiazol-2-yl)methyl]-1-[1- methylpropyl]pyrazolo[4,3-b]pyridin-7-amine, enantiomer 1::US11491140, Example 123 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 54.0 US Patent 10.7270/Q2R78K2T US11491140 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=580548 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=580548&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 140830767 475726394 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234763 CCOc1ncccc1-c1cc(N2CCCC2)c2n(ncc2n1)C1COC1 InChI=1S/C20H23N5O2/c1-2-27-20-15(6-5-7-21-20)16-10-18(24-8-3-4-9-24)19-17(23-16)11-22-25(19)14-12-26-13-14/h5-7,10-11,14H,2-4,8-9,12-13H2,1H3 MZOCQVQIWJPCHX-UHFFFAOYSA-N 587569 5-(2-ethoxy-3-pyridyl)-1-(oxetan-3-yl)-7- pyrrolidin-1-yl-pyrazolo[4,3-b]pyridine::US11535611, Example 4 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 641 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587569 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587569&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234766 CCOc1ncccc1-c1cc(NC[C@@H]2CCCO2)c2n(ncc2n1)C(C)C InChI=1S/C21H27N5O2/c1-4-27-21-16(8-5-9-22-21)17-11-18(23-12-15-7-6-10-28-15)20-19(25-17)13-24-26(20)14(2)3/h5,8-9,11,13-15H,4,6-7,10,12H2,1-3H3,(H,23,25)/t15-/m0/s1 HIAMRTZPJJKUES-HNNXBMFYSA-N 587581 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N- [[(2S)-tetrahydrofuran-2- yl]methyl]pyrazolo[4,3-b]pyridin-7-amine::US11535611, Example 6 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 653 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587581 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587581&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234769 CCOc1ncccc1-c1cc(NC[C@H]2CCCO2)c2n(ncc2n1)C(C)C InChI=1S/C21H27N5O2/c1-4-27-21-16(8-5-9-22-21)17-11-18(23-12-15-7-6-10-28-15)20-19(25-17)13-24-26(20)14(2)3/h5,8-9,11,13-15H,4,6-7,10,12H2,1-3H3,(H,23,25)/t15-/m1/s1 HIAMRTZPJJKUES-OAHLLOKOSA-N 587583 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N- [[(2R)-tetrahydrofuran-2- yl]methyl]pyrazolo[4,3-b]pyridin-7-amine::US11535611, Example 7 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 449 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587583 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587583&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234772 CCOc1ncccc1-c1cc(N[C@@H]2CCCOC2)c2n(ncc2n1)C(C)C InChI=1S/C21H27N5O2/c1-4-28-21-16(8-5-9-22-21)17-11-18(24-15-7-6-10-27-13-15)20-19(25-17)12-23-26(20)14(2)3/h5,8-9,11-12,14-15H,4,6-7,10,13H2,1-3H3,(H,24,25)/t15-/m1/s1 WSLKNNDWDHGJQK-OAHLLOKOSA-N 587584 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(3R)- tetrahydropyran-3-yl]pyrazolo[4,3- b]pyridin-7-amine::US11535611, Example 8 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2156 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587584 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587584&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234775 CCOc1ncccc1-c1cc(N[C@H]2CCCOC2)c2n(ncc2n1)C(C)C InChI=1S/C21H27N5O2/c1-4-28-21-16(8-5-9-22-21)17-11-18(24-15-7-6-10-27-13-15)20-19(25-17)12-23-26(20)14(2)3/h5,8-9,11-12,14-15H,4,6-7,10,13H2,1-3H3,(H,24,25)/t15-/m0/s1 WSLKNNDWDHGJQK-HNNXBMFYSA-N 587585 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(3S)- tetrahydropyran-3-yl]pyrazolo[4,3- b]pyridin-7-amine::US11535611, Example 9 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 687 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587585 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587585&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234780 CCOc1ncccc1-c1cc(N[C@@H]2COC[C@H]2OC)c2n(ncc2n1)C(C)C InChI=1S/C21H27N5O3/c1-5-29-21-14(7-6-8-22-21)15-9-16(25-18-11-28-12-19(18)27-4)20-17(24-15)10-23-26(20)13(2)3/h6-10,13,18-19H,5,11-12H2,1-4H3,(H,24,25)/t18-,19-/m1/s1 ODAVXTCJLMTDFI-RTBURBONSA-N 587594 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N- [trans-4-methoxytetrahydrofuran-3- yl]pyrazolo[4,3-b]pyridin-7-amine::US11535611, Example 11 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 575 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587594 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587594&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234783 CCOc1ncccc1-c1cc(NC(C)C)c2n(ncc2n1)C(C)C InChI=1S/C19H25N5O/c1-6-25-19-14(8-7-9-20-19)15-10-16(22-12(2)3)18-17(23-15)11-21-24(18)13(4)5/h7-13H,6H2,1-5H3,(H,22,23) MPWMWZNOSQQPQL-UHFFFAOYSA-N 587596 5-(2-ethoxy-3-pyridyl)-N,1-diisopropyl- pyrazolo[4,3-b]pyridin-7-amine::US11535611, Example 12 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1118 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587596 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587596&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234786 CCOc1ncccc1-c1cc(NC)c2n(ncc2n1)C(C)C InChI=1S/C17H21N5O/c1-5-23-17-12(7-6-8-19-17)13-9-14(18-4)16-15(21-13)10-20-22(16)11(2)3/h6-11H,5H2,1-4H3,(H,18,21) VWUGGYFUCXBOHR-UHFFFAOYSA-N 587597 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N- methyl-pyrazolo[4,3-b]pyridin-7-amine::US11535611, Example 13 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1029 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587597&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234789 CCOc1ncccc1-c1cc(N2CCCC2)c2n(C)ncc2n1 InChI=1S/C18H21N5O/c1-3-24-18-13(7-6-8-19-18)14-11-16(23-9-4-5-10-23)17-15(21-14)12-20-22(17)2/h6-8,11-12H,3-5,9-10H2,1-2H3 CNDFHFACHKNMQH-UHFFFAOYSA-N 587639 5-(2-ethoxy-3-pyridyl)-1-methyl-7- pyrrolidin-1-yl-pyrazolo[4,3-b]pyridine::US11535611, Example 14 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1092 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587639 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587639&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234792 CCOc1ncccc1-c1nc2c(C)nn(CC)c2cc1C InChI=1S/C17H20N4O/c1-5-21-14-10-11(3)15(19-16(14)12(4)20-21)13-8-7-9-18-17(13)22-6-2/h7-10H,5-6H2,1-4H3 VAZHDIZUYWHZFW-UHFFFAOYSA-N 587646 5-(2-ethoxy-3-pyridyl)-1-ethyl-3,6- dimethyl-pyrazolo[4,3-b]pyridine::US11535611, Example 15 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1007 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587646 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587646&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234795 CCOc1ncccc1-c1cc(N2CCCC2)c2n(CC)ncc2n1 InChI=1S/C19H23N5O/c1-3-24-18-16(13-21-24)22-15(12-17(18)23-10-5-6-11-23)14-8-7-9-20-19(14)25-4-2/h7-9,12-13H,3-6,10-11H2,1-2H3 XQZOCZINLVECTD-UHFFFAOYSA-N 587648 5-(2-ethoxy-3-pyridyl)-1-ethyl-7-pyrrolidin- 1-yl-pyrazolo[4,3-b]pyridine::US11535611, Example 16 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 461 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587648 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587648&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234798 CCOc1ncccc1-c1cc(N2CCCC2)c2n(ncc2n1)C(C)C InChI=1S/C20H25N5O/c1-4-26-20-15(8-7-9-21-20)16-12-18(24-10-5-6-11-24)19-17(23-16)13-22-25(19)14(2)3/h7-9,12-14H,4-6,10-11H2,1-3H3 OAFVIHQZGHZRRA-UHFFFAOYSA-N 587649 5-(2-ethoxy-3-pyridyl)-1-isopropyl-7- pyrrolidin-1-yl-pyrazolo[4,3-b]pyridine::US11535611, Example 17 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 353 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587649 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587649&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234800 CCCn1ncc2nc(cc(N3CCCC3)c12)-c1cccnc1OCC InChI=1S/C20H25N5O/c1-3-10-25-19-17(14-22-25)23-16(13-18(19)24-11-5-6-12-24)15-8-7-9-21-20(15)26-4-2/h7-9,13-14H,3-6,10-12H2,1-2H3 KPRJCTUCKTYELS-UHFFFAOYSA-N 587650 5-(2-ethoxy-3-pyridyl)-1-propyl-7- pyrrolidin-1-yl-pyrazolo[4,3-b]pyridine::US11535611, Example 18 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 637 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587650 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587650&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234802 CCOc1ncccc1-c1cc(N[C@@H]2CCOC2)c2n(CC)ncc2n1 InChI=1S/C19H23N5O2/c1-3-24-18-16(22-13-7-9-25-12-13)10-15(23-17(18)11-21-24)14-6-5-8-20-19(14)26-4-2/h5-6,8,10-11,13H,3-4,7,9,12H2,1-2H3,(H,22,23)/t13-/m1/s1 UXZFMELJCXGOCQ-CYBMUJFWSA-N 587651 5-(2-ethoxy-3-pyridyl)-1-ethyl-N- [tetrahydrofuran-3-yl]pyrazolo[4,3- b]pyridin-7-amine, enantiomer 1::US11535611, Example 19 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 326 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587651 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587651&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234805 CCOc1ncccc1-c1cc(N[C@H]2CCOC2)c2n(CC)ncc2n1 InChI=1S/C19H23N5O2/c1-3-24-18-16(22-13-7-9-25-12-13)10-15(23-17(18)11-21-24)14-6-5-8-20-19(14)26-4-2/h5-6,8,10-11,13H,3-4,7,9,12H2,1-2H3,(H,22,23)/t13-/m0/s1 UXZFMELJCXGOCQ-ZDUSSCGKSA-N 587652 5-(2-ethoxy-3-pyridyl)-1-ethyl-N- [tetrahydrofuran-3-yl]pyrazolo[4,3- b]pyridin-7-amine, enantiomer 2::US11535611, Example 20 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 467 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587652 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587652&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234808 CCOc1ncccc1-c1cc(N[C@H]2CCOC2)c2n(ncc2n1)C(C)C InChI=1S/C20H25N5O2/c1-4-27-20-15(6-5-8-21-20)16-10-17(23-14-7-9-26-12-14)19-18(24-16)11-22-25(19)13(2)3/h5-6,8,10-11,13-14H,4,7,9,12H2,1-3H3,(H,23,24)/t14-/m0/s1 JBTCDZVDBOMRFT-AWEZNQCLSA-N 587653 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N- [tetrahydrofuran-3-yl]pyrazolo[4,3- b]pyridin-7-amine, enantiomer 1::US11535611, Example 21 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 622 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587653 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587653&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234811 CCOc1ncccc1-c1cc(N[C@@H]2CCOC2)c2n(ncc2n1)C(C)C InChI=1S/C20H25N5O2/c1-4-27-20-15(6-5-8-21-20)16-10-17(23-14-7-9-26-12-14)19-18(24-16)11-22-25(19)13(2)3/h5-6,8,10-11,13-14H,4,7,9,12H2,1-3H3,(H,23,24)/t14-/m1/s1 JBTCDZVDBOMRFT-CQSZACIVSA-N 587654 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N- [tetrahydrofuran-3-yl]pyrazolo[4,3- b]pyridin-7-amine, enantiomer 2::US11535611, Example 22 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 458 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587654&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234814 CCCn1ncc2nc(cc(N[C@@H]3CCOC3)c12)-c1cccnc1OCC InChI=1S/C20H25N5O2/c1-3-9-25-19-17(23-14-7-10-26-13-14)11-16(24-18(19)12-22-25)15-6-5-8-21-20(15)27-4-2/h5-6,8,11-12,14H,3-4,7,9-10,13H2,1-2H3,(H,23,24)/t14-/m1/s1 LXIXZJSFHDNFEZ-CQSZACIVSA-N 587655 5-(2-ethoxy-3-pyridyl)-1-propyl-N- [tetrahydrofuran-3-yl]pyrazolo[4,3- b]pyridin-7-amine, enantiomer 1::US11535611, Example 23 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 481 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587655&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234817 CCCn1ncc2nc(cc(N[C@H]3CCOC3)c12)-c1cccnc1OCC InChI=1S/C20H25N5O2/c1-3-9-25-19-17(23-14-7-10-26-13-14)11-16(24-18(19)12-22-25)15-6-5-8-21-20(15)27-4-2/h5-6,8,11-12,14H,3-4,7,9-10,13H2,1-2H3,(H,23,24)/t14-/m0/s1 LXIXZJSFHDNFEZ-AWEZNQCLSA-N 587656 5-(2-ethoxy-3-pyridyl)-1-propyl-N- [tetrahydrofuran-3-yl]pyrazolo[4,3- b]pyridin-7-amine, enantiomer 2::US11535611, Example 24 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 327 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587656 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587656&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234820 CC(C)n1ncc2nc(cc(N[C@@H]3CCOC3)c12)-c1cccnc1 InChI=1S/C18H21N5O/c1-12(2)23-18-16(21-14-5-7-24-11-14)8-15(22-17(18)10-20-23)13-4-3-6-19-9-13/h3-4,6,8-10,12,14H,5,7,11H2,1-2H3,(H,21,22)/t14-/m1/s1 ZZEWGRHZCLIBAB-CQSZACIVSA-N 587657 1-isopropyl-5-(3-pyridyl)-N-[(3R)- tetrahydrofuran-3-yl]pyrazolo[4,3- b]pyridin-7-amine::US11535611, Example 25 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2159 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587657 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587657&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234823 CC(C)n1ncc2nc(cc(N[C@@H]3CCOC3)c12)-c1ccccc1 InChI=1S/C19H22N4O/c1-13(2)23-19-17(21-15-8-9-24-12-15)10-16(22-18(19)11-20-23)14-6-4-3-5-7-14/h3-7,10-11,13,15H,8-9,12H2,1-2H3,(H,21,22)/t15-/m1/s1 NZLUPKMFVHBPTA-OAHLLOKOSA-N 587659 1-isopropyl-5-phenyl-N-[(3R)- tetrahydrofuran-3-yl]pyrazolo[4,3- b]pyridin-7-amine::US11535611, Example 27 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2004 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587659 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587659&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234826 COc1ncccc1-c1cc(N[C@@H]2CCOC2)c2n(ncc2n1)C(C)C InChI=1S/C19H23N5O2/c1-12(2)24-18-16(22-13-6-8-26-11-13)9-15(23-17(18)10-21-24)14-5-4-7-20-19(14)25-3/h4-5,7,9-10,12-13H,6,8,11H2,1-3H3,(H,22,23)/t13-/m1/s1 DAFCUKHUCRIICD-CYBMUJFWSA-N 587660 1-isopropyl-5-(2-methoxy-3-pyridyl)-N- [(3R)-tetrahydrofuran-3-yl]pyrazolo[4,3- b]pyridin-7-amine::US11535611, Example 28 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 533 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587660 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587660&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234830 COc1cnccc1-c1cc(N[C@@H]2CCOC2)c2n(ncc2n1)C(C)C InChI=1S/C19H23N5O2/c1-12(2)24-19-16(22-13-5-7-26-11-13)8-15(23-17(19)9-21-24)14-4-6-20-10-18(14)25-3/h4,6,8-10,12-13H,5,7,11H2,1-3H3,(H,22,23)/t13-/m1/s1 YVEDHDOMUQCNFK-CYBMUJFWSA-N 587662 1-isopropyl-5-(3-methoxy-4-pyridyl)-N- [(3R)-tetrahydrofuran-3-yl]pyrazolo[4,3- b]pyridin-7-amine::US11535611, Example 30 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1554 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587662 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587662&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234834 CC(C)n1ncc2nc(cc(N[C@@H]3CCOC3)c12)-c1cccc2OCOc12 InChI=1S/C20H22N4O3/c1-12(2)24-19-16(22-13-6-7-25-10-13)8-15(23-17(19)9-21-24)14-4-3-5-18-20(14)27-11-26-18/h3-5,8-9,12-13H,6-7,10-11H2,1-2H3,(H,22,23)/t13-/m1/s1 RTGGBZBOUNVUHO-CYBMUJFWSA-N 587664 5-(1,3-benzodioxol-4-yl)-1-isopropyl-N- [(3R)-tetrahydrofuran-3-yl]pyrazolo[4,3- b]pyridin-7-amine::US11535611, Example 32 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1294 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587664 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587664&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234837 CCOc1nccc(C)c1-c1cc(N[C@@H]2CCOC2)c2n(ncc2n1)C(C)C InChI=1S/C21H27N5O2/c1-5-28-21-19(14(4)6-8-22-21)16-10-17(24-15-7-9-27-12-15)20-18(25-16)11-23-26(20)13(2)3/h6,8,10-11,13,15H,5,7,9,12H2,1-4H3,(H,24,25)/t15-/m1/s1 BEWJVJUTJZTWQQ-OAHLLOKOSA-N 587665 5-(2-ethoxy-4-methyl-3-pyridyl)-1- isopropyl-N-[(3R)-tetrahydrofuran-3- yl]pyrazolo[4,3-b]pyridin-7-amine::US11535611, Example 34 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 380 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587665&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234840 CC(C)n1ncc2nc(cc(N[C@@H]3CCOC3)c12)-c1cnn2ccccc12 InChI=1S/C20H22N6O/c1-13(2)26-20-17(23-14-6-8-27-12-14)9-16(24-18(20)11-22-26)15-10-21-25-7-4-3-5-19(15)25/h3-5,7,9-11,13-14H,6,8,12H2,1-2H3,(H,23,24)/t14-/m1/s1 USWHMSHJNLFACZ-CQSZACIVSA-N 587666 1-isopropyl-5-pyrazolo[1,5-a]pyridin-3-yl- N-[(3R)-tetrahydrofuran-3-yl]pyrazolo[4,3- b]pyridin-7-amine::US11535611, Example 35 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1621 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587666 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587666&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234843 CC(C)n1ncc2nc(cc(N[C@@H]3CCOC3)c12)-c1cccnc1OC(C)(C)C InChI=1S/C22H29N5O2/c1-14(2)27-20-18(25-15-8-10-28-13-15)11-17(26-19(20)12-24-27)16-7-6-9-23-21(16)29-22(3,4)5/h6-7,9,11-12,14-15H,8,10,13H2,1-5H3,(H,25,26)/t15-/m1/s1 ONUWUZXNTMRHEG-OAHLLOKOSA-N 587667 5-(2-tert-butoxy-3-pyridyl)-1-isopropyl-N- [(3R)-tetrahydrofuran-3-yl]pyrazolo[4,3- b]pyridin-7-amine::US11535611, Example 36 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 260 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587667 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587667&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234848 COc1cc(c(OC)cn1)-c1cc(N[C@@H]2CCOC2)c2n(ncc2n1)C(C)C InChI=1S/C20H25N5O3/c1-12(2)25-20-16(23-13-5-6-28-11-13)8-15(24-17(20)9-22-25)14-7-19(27-4)21-10-18(14)26-3/h7-10,12-13H,5-6,11H2,1-4H3,(H,23,24)/t13-/m1/s1 FUMQGQGPKVHDSV-CYBMUJFWSA-N 587669 5-(2,5-dimethoxy-4-pyridyl)-1-isopropyl-N- [(3R)-tetrahydrofuran-3-yl]pyrazolo[4,3- b]pyridin-7-amine::US11535611, Example 38 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1160 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587669 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587669&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234853 CC(C)n1ncc2nc(cc(N[C@@H]3CCOC3)c12)-c1ccccc1C#N InChI=1S/C20H21N5O/c1-13(2)25-20-18(23-15-7-8-26-12-15)9-17(24-19(20)11-22-25)16-6-4-3-5-14(16)10-21/h3-6,9,11,13,15H,7-8,12H2,1-2H3,(H,23,24)/t15-/m1/s1 MNLJXFJFDDDISE-OAHLLOKOSA-N 587672 2-[1-isopropyl-7-[[(3R)-tetrahydrofuran-3- yl]amino]pyrazolo[4,3-b]pyridin-5- yl]benzonitrile::US11535611, Example 41 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 951 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587672&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234856 CC(C)n1ncc2nc(cc(N[C@@H]3CCOC3)c12)-c1cccc2OCCOc12 InChI=1S/C21H24N4O3/c1-13(2)25-20-17(23-14-6-7-26-12-14)10-16(24-18(20)11-22-25)15-4-3-5-19-21(15)28-9-8-27-19/h3-5,10-11,13-14H,6-9,12H2,1-2H3,(H,23,24)/t14-/m1/s1 IPTBKUJJQQFGQU-CQSZACIVSA-N 587673 5-(2,3-dihydro-1,4-benzodioxin-5-yl)-1- isopropyl-N-[(3R)-tetrahydrofuran-3- yl]pyrazolo[4,3-b]pyridin-7-amine::US11535611, Example 42 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1570 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587673&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234858 CC(C)n1ncc2nc(Cc3ccc(F)cc3)cc(N[C@@H]3CCOC3)c12 InChI=1S/C20H23FN4O/c1-13(2)25-20-18(23-16-7-8-26-12-16)10-17(24-19(20)11-22-25)9-14-3-5-15(21)6-4-14/h3-6,10-11,13,16H,7-9,12H2,1-2H3,(H,23,24)/t16-/m1/s1 STTOMOGDSKUZLD-MRXNPFEDSA-N 587674 5-[(4-fluorophenyl)methyl]-1-isopropyl-N- [(3R)-tetrahydrofuran-3-yl]pyrazolo[4,3- b]pyridin-7-amine::US11535611, Example 43 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2856 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587674 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587674&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234862 COCc1cccc(c1)-c1cc(N[C@@H]2CCOC2)c2n(ncc2n1)C(C)C InChI=1S/C21H26N4O2/c1-14(2)25-21-19(23-17-7-8-27-13-17)10-18(24-20(21)11-22-25)16-6-4-5-15(9-16)12-26-3/h4-6,9-11,14,17H,7-8,12-13H2,1-3H3,(H,23,24)/t17-/m1/s1 DABNLNGDKZAEAJ-QGZVFWFLSA-N 587676 1-isopropyl-5-[3-(methoxymethyl)phenyl]- N-[(3R)-tetrahydrofuran-3-yl]pyrazolo[4,3- b]pyridin-7-amine::US11535611, Example 45 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2480 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587676&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234866 COc1cncc(c1)-c1cc(N[C@@H]2CCOC2)c2n(ncc2n1)C(C)C InChI=1S/C19H23N5O2/c1-12(2)24-19-17(22-14-4-5-26-11-14)7-16(23-18(19)10-21-24)13-6-15(25-3)9-20-8-13/h6-10,12,14H,4-5,11H2,1-3H3,(H,22,23)/t14-/m1/s1 CVIGMQFSENBFLC-CQSZACIVSA-N 587678 1-isopropyl-5-(5-methoxy-3-pyridyl)-N- [(3R)-tetrahydrofuran-3-yl]pyrazolo[4,3- b]pyridin-7-amine::US11535611, Example 47 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1520 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587678&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234869 CC(C)n1ncc2nc(cc(N[C@@H]3CCOC3)c12)-c1cccc(OC(F)F)c1 InChI=1S/C20H22F2N4O2/c1-12(2)26-19-17(24-14-6-7-27-11-14)9-16(25-18(19)10-23-26)13-4-3-5-15(8-13)28-20(21)22/h3-5,8-10,12,14,20H,6-7,11H2,1-2H3,(H,24,25)/t14-/m1/s1 LJAABDRXLATXLP-CQSZACIVSA-N 587679 5-[3-(difluoromethoxy)phenyl]-1- isopropyl-N-[(3R)-tetrahydrofuran-3- yl]pyrazolo[4,3-b]pyridin-7-amine::US11535611, Example 48 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1099 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587679&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234874 CCOc1ncncc1-c1cc(N[C@H]2CCOC2)c2n(ncc2n1)C(C)C InChI=1S/C19H24N6O2/c1-4-27-19-14(8-20-11-21-19)15-7-16(23-13-5-6-26-10-13)18-17(24-15)9-22-25(18)12(2)3/h7-9,11-13H,4-6,10H2,1-3H3,(H,23,24)/t13-/m0/s1 VAYHPHVSGRCMTH-ZDUSSCGKSA-N 587681 5-(4-ethoxypyrimidin-5-yl)-1-isopropyl-N- [(3R)-tetrahydrofuran-3-yl]pyrazolo[4,3- b]pyridin-7-amine::US11535611, Example 50 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2995 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587681&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234887 COc1ccc(Cc2cc(N[C@@H]3CCOC3)c3n(ncc3n2)C(C)C)cc1 InChI=1S/C21H26N4O2/c1-14(2)25-21-19(23-16-8-9-27-13-16)11-17(24-20(21)12-22-25)10-15-4-6-18(26-3)7-5-15/h4-7,11-12,14,16H,8-10,13H2,1-3H3,(H,23,24)/t16-/m1/s1 GOAYGCUXFWVPLK-MRXNPFEDSA-N 587688 1-isopropyl-5-[(4-methoxyphenyl)methyl]- N-[(3R)-tetrahydrofuran-3-yl]pyrazolo[4,3- b]pyridin-7-amine::US11535611, Example 57 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 874 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587688 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587688&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234891 CCOc1ncccc1-c1ccc2n(nc(C)c2n1)C(C)C InChI=1S/C17H20N4O/c1-5-22-17-13(7-6-10-18-17)14-8-9-15-16(19-14)12(4)20-21(15)11(2)3/h6-11H,5H2,1-4H3 XDUFEFLSVNKEIU-UHFFFAOYSA-N 587690 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3- methyl-pyrazolo[4,3-b]pyridine::US11535611, Example 59 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 52.0 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587690&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234894 CC(C)n1nc(C)c2nc(c(C)cc12)-c1ccccc1 InChI=1S/C17H19N3/c1-11(2)20-15-10-12(3)16(14-8-6-5-7-9-14)18-17(15)13(4)19-20/h5-11H,1-4H3 NHTZYYDADSWQFF-UHFFFAOYSA-N 587691 1-isopropyl-3,6-dimethyl-5-phenyl- pyrazolo[4,3-b]pyridine::US11535611, Example 60 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 225 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587691 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587691&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234897 COc1ncccc1-c1nc2c(C)nn(C(C)C)c2cc1C InChI=1S/C17H20N4O/c1-10(2)21-14-9-11(3)15(19-16(14)12(4)20-21)13-7-6-8-18-17(13)22-5/h6-10H,1-5H3 PHHOODNTGCUZFM-UHFFFAOYSA-N 587692 1-isopropyl-5-(2-methoxy-3-pyridyl)-3,6- dimethyl-pyrazolo[4,3-b]pyridine::US11535611, Example 61 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 288 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587692&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234900 COc1ccccc1-c1nc2c(C)nn(C(C)C)c2cc1C InChI=1S/C18H21N3O/c1-11(2)21-15-10-12(3)17(19-18(15)13(4)20-21)14-8-6-7-9-16(14)22-5/h6-11H,1-5H3 OSBOOFALLQCYDR-UHFFFAOYSA-N 587693 1-isopropyl-5-(2-methoxyphenyl)-3,6- dimethyl-pyrazolo[4,3-b]pyridine::US11535611, Example 62 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 694 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587693&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234903 CCOc1ncccc1-c1nc2c(C)nn(C(C)C)c2cc1C InChI=1S/C18H22N4O/c1-6-23-18-14(8-7-9-19-18)16-12(4)10-15-17(20-16)13(5)21-22(15)11(2)3/h7-11H,6H2,1-5H3 BFRDRFVRTDDXOO-UHFFFAOYSA-N 587694 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3,6- dimethyl-pyrazolo[4,3-b]pyridine::US11535611, Example 63 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 86.0 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587694 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587694&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234906 CCCOc1ncccc1-c1nc2c(C)nn(C(C)C)c2cc1C InChI=1S/C19H24N4O/c1-6-10-24-19-15(8-7-9-20-19)17-13(4)11-16-18(21-17)14(5)22-23(16)12(2)3/h7-9,11-12H,6,10H2,1-5H3 GLUMAFSYFKCMND-UHFFFAOYSA-N 587695 1-isopropyl-3,6-dimethyl-5-(2-propoxy-3- pyridyl)pyrazolo[4,3-b]pyridine::US11535611, Example 64 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 118 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587695 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587695&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234909 CCOc1ncccc1-c1cc(NC)c2n(nc(C)c2n1)C(C)C InChI=1S/C18H23N5O/c1-6-24-18-13(8-7-9-20-18)14-10-15(19-5)17-16(21-14)12(4)22-23(17)11(2)3/h7-11H,6H2,1-5H3,(H,19,21) ABXBWGWLDQBUBP-UHFFFAOYSA-N 587696 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N,3- dimethyl-pyrazolo[4,3-b]pyridin-7-amine::US11535611, Example 65 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 50.0 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587696 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587696&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234912 CCNc1cc(nc2c(C)nn(C(C)C)c12)-c1cccnc1OCC InChI=1S/C19H25N5O/c1-6-20-16-11-15(14-9-8-10-21-19(14)25-7-2)22-17-13(5)23-24(12(3)4)18(16)17/h8-12H,6-7H2,1-5H3,(H,20,22) IEMFUUSWJIFFAI-UHFFFAOYSA-N 587697 5-(2-ethoxy-3-pyridyl)-N-ethyl-1-isopropyl- 3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US11535611, Example 66 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 60.0 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587697 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587697&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234915 CCOc1ncccc1-c1cc(NCC2CCC(=O)N2C)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H30N6O2/c1-6-31-23-17(8-7-11-24-23)18-12-19(25-13-16-9-10-20(30)28(16)5)22-21(26-18)15(4)27-29(22)14(2)3/h7-8,11-12,14,16H,6,9-10,13H2,1-5H3,(H,25,26) GBCXKXMTXPRTLX-UHFFFAOYSA-N 587698 (+-)-5-[[[5-(2-ethoxy-3-pyridyl)-1-isopropyl- 3-methyl-pyrazolo[4,3-b]pyridin-7- yl]amino]methyl]-1-methyl-pyrrolidin-2- one::US11535611, Example 67 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 70.0 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587698 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587698&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234918 CCOc1ncccc1-c1cc(NCC2CN(C)C(=O)C2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H30N6O2/c1-6-31-23-17(8-7-9-24-23)18-11-19(25-12-16-10-20(30)28(5)13-16)22-21(26-18)15(4)27-29(22)14(2)3/h7-9,11,14,16H,6,10,12-13H2,1-5H3,(H,25,26) CFQXXHJNMLSQHZ-UHFFFAOYSA-N 587699 4-[[[5-(2-ethoxy-3-pyridyl)-1-isopropyl-3- methyl-pyrazolo[4,3-b]pyridin-7- yl]amino]methyl]-1-methyl-pyrrolidin-2- one::US11535611, Example 68 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 53.0 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587699 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587699&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234921 CCOc1ncccc1-c1cc(N)c2n(nc(C)c2n1)C(C)C InChI=1S/C17H21N5O/c1-5-23-17-12(7-6-8-19-17)14-9-13(18)16-15(20-14)11(4)21-22(16)10(2)3/h6-10H,5H2,1-4H3,(H2,18,20) JHUKRVJWFMXMQR-UHFFFAOYSA-N 587700 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3- methyl-pyrazolo[4,3-b]pyridin-7-amine::US11535611, Example 69 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 62.0 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587700 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587700&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234924 CCOc1ncccc1-c1ccc2n(ncc2n1)C(C)C InChI=1S/C16H18N4O/c1-4-21-16-12(6-5-9-17-16)13-7-8-15-14(19-13)10-18-20(15)11(2)3/h5-11H,4H2,1-3H3 ZDEYBOGYJCESDB-UHFFFAOYSA-N 587701 5-(2-ethoxy-3-pyridyl)-1-isopropyl- pyrazolo[4,3-b]pyridine::US11535611, Example 70 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 836 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587701 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587701&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234927 CCOc1ncccc1-c1nc2c(C)nc(C(C)C)n2cc1C InChI=1S/C18H22N4O/c1-6-23-18-14(8-7-9-19-18)15-12(4)10-22-16(11(2)3)20-13(5)17(22)21-15/h7-11H,6H2,1-5H3 CEXMMUZLWOYRDY-UHFFFAOYSA-N 587702 2-(2-ethoxy-3-pyridyl)-6-isopropyl-3,8- dimethyl-imidazo[1,5-a]pyrimidine::US11535611, Example 71 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 74.0 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587702 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587702&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234930 CCOc1ncccc1-c1ccn2c(nc(C)c2n1)C(C)C InChI=1S/C17H20N4O/c1-5-22-17-13(7-6-9-18-17)14-8-10-21-15(11(2)3)19-12(4)16(21)20-14/h6-11H,5H2,1-4H3 WIOSRHGIFUMFNQ-UHFFFAOYSA-N 587703 2-(2-ethoxy-3-pyridyl)-6-isopropyl-8- methyl-imidazo[1,5-a]pyrimidine::US11535611, Example 72 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 96.0 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587703 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587703&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234933 CCOc1ncccc1-c1ccn2c(nc(C)c2n1)C1CCC1 InChI=1S/C18H20N4O/c1-3-23-18-14(8-5-10-19-18)15-9-11-22-16(21-15)12(2)20-17(22)13-6-4-7-13/h5,8-11,13H,3-4,6-7H2,1-2H3 BNYIEPJRYJQTHM-UHFFFAOYSA-N 587704 6-cyclobutyl-2-(2-ethoxy-3-pyridyl)-8- methyl-imidazo[1,5-a]pyrimidine::US11535611, Example 73::US11535611, Example 74 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1554 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587704 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587704&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234936 CCOc1ncccc1-c1ccn2c(nc(C)c2n1)C1CCC1 InChI=1S/C18H20N4O/c1-3-23-18-14(8-5-10-19-18)15-9-11-22-16(21-15)12(2)20-17(22)13-6-4-7-13/h5,8-11,13H,3-4,6-7H2,1-2H3 BNYIEPJRYJQTHM-UHFFFAOYSA-N 587704 6-cyclobutyl-2-(2-ethoxy-3-pyridyl)-8- methyl-imidazo[1,5-a]pyrimidine::US11535611, Example 73::US11535611, Example 74 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 394 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587704 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587704&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234939 CCOc1ncccc1-c1ccn2c(nc(C)c2n1)C(CC)CC InChI=1S/C19H24N4O/c1-5-14(6-2)18-21-13(4)17-22-16(10-12-23(17)18)15-9-8-11-20-19(15)24-7-3/h8-12,14H,5-7H2,1-4H3 MNWITQKMYDXVBF-UHFFFAOYSA-N 587706 2-(2-ethoxy-3-pyridyl)-6-(1-ethylpropyl)-8- methyl-imidazo[1,5-a]pyrimidine::US11535611, Example 75 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 244 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587706 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587706&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234942 CCOc1ncccc1-c1ccn2c(nc(C)c2n1)C(C)CC InChI=1S/C18H22N4O/c1-5-12(3)16-20-13(4)17-21-15(9-11-22(16)17)14-8-7-10-19-18(14)23-6-2/h7-12H,5-6H2,1-4H3 YVGRAQYGPYHZDK-UHFFFAOYSA-N 587707 (+-)-2-(2-ethoxy-3-pyridyl)-8-methyl-6-sec- butyl-imidazo[1,5-a]pyrimidine::US11535611, Example 76 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 61.0 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587707&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234945 CCOc1ncccc1-c1ccn2c(nc(C)c2n1)C1(C)COC1 InChI=1S/C18H20N4O2/c1-4-24-16-13(6-5-8-19-16)14-7-9-22-15(21-14)12(2)20-17(22)18(3)10-23-11-18/h5-9H,4,10-11H2,1-3H3 BPTCRJBPJDAUBH-UHFFFAOYSA-N 587708 2-(2-ethoxy-3-pyridyl)-8-methyl-6-(3- methyloxetan-3-yl)imidazo[1,5- a]pyrimidine::US11535611, Example 77 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 448 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587708 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587708&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234948 CCOc1ncccc1-c1ccn2c(CC(F)(F)F)nc(C)c2n1 InChI=1S/C16H15F3N4O/c1-3-24-15-11(5-4-7-20-15)12-6-8-23-13(9-16(17,18)19)21-10(2)14(23)22-12/h4-8H,3,9H2,1-2H3 PDEQSHWWQUGZQW-UHFFFAOYSA-N 587709 2-(2-ethoxy-3-pyridyl)-8-methyl-6-(2,2,2- trifluoroethyl)imidazo[1,5-a]pyrimidine::US11535611, Example 78 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 321 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587709 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587709&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234951 CCOc1ncccc1-c1ccn2c(nc(C)c2n1)C1COC1 InChI=1S/C17H18N4O2/c1-3-23-17-13(5-4-7-18-17)14-6-8-21-15(20-14)11(2)19-16(21)12-9-22-10-12/h4-8,12H,3,9-10H2,1-2H3 UBSAKYMRJJOZDY-UHFFFAOYSA-N 587710 2-(2-ethoxy-3-pyridyl)-8-methyl-6-(oxetan- 3-yl)imidazo[1,5-a]pyrimidine::US11535611, Example 79 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 406 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587710&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234954 CCOc1ncccc1-c1ccn2c(nc(C)c2n1)C1CCCC1 InChI=1S/C19H22N4O/c1-3-24-19-15(9-6-11-20-19)16-10-12-23-17(22-16)13(2)21-18(23)14-7-4-5-8-14/h6,9-12,14H,3-5,7-8H2,1-2H3 MGYYMRJQUAMUAS-UHFFFAOYSA-N 587711 6-cyclopentyl-2-(2-ethoxy-3-pyridyl)-8- methyl-imidazo[1,5-a]pyrimidine::US11535611, Example 80 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 3232 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587711 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587711&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234957 CCOc1ncccc1-c1ccn2c(nc(C)c2n1)C1CCOC1 InChI=1S/C18H20N4O2/c1-3-24-18-14(5-4-8-19-18)15-6-9-22-16(21-15)12(2)20-17(22)13-7-10-23-11-13/h4-6,8-9,13H,3,7,10-11H2,1-2H3 VVCJQASQABSXFG-UHFFFAOYSA-N 587712 (+-)-2-(2-ethoxy-3-pyridyl)-8-methyl-6- tetrahydrofuran-3-yl-imidazo[1,5- a]pyrimidine::US11535611, Example 81 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1126 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587712 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587712&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234960 CCOc1ncccc1-c1ccn2c(nc(C)c2n1)[C@H](C)CC InChI=1S/C18H22N4O/c1-5-12(3)16-20-13(4)17-21-15(9-11-22(16)17)14-8-7-10-19-18(14)23-6-2/h7-12H,5-6H2,1-4H3/t12-/m1/s1 YVGRAQYGPYHZDK-GFCCVEGCSA-N 587713 2-(2-ethoxy-3-pyridyl)-8-methyl-6-[1- methylpropyl]imidazo[1,5-a]pyrimidine, enantiomer 1::US11535611, Example 83 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 51.0 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587713 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587713&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1234963 CCOc1ncccc1-c1ccn2c(nc(C)c2n1)[C@@H](C)CC InChI=1S/C18H22N4O/c1-5-12(3)16-20-13(4)17-21-15(9-11-22(16)17)14-8-7-10-19-18(14)23-6-2/h7-12H,5-6H2,1-4H3/t12-/m0/s1 YVGRAQYGPYHZDK-LBPRGKRZSA-N 587714 2-(2-ethoxy-3-pyridyl)-8-methyl-6-[1- methylpropyl]imidazo[1,5-a]pyrimidine, enantiomer 2::US11535611, Example 84 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 159 US Patent 10.7270/Q2GB27X5 US11535611 Kehler, J; Rasmussen, LK; Langgard, M; Jessing, M; Vital, PJ; Juhl, K; Marigo, M H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=587714 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=587714&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272999 CCOc1ncccc1-c1cc(NCc2cnc(C)o2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C23H28N6O2/c1-6-14(3)29-22-20(26-13-17-12-25-16(5)31-17)11-19(27-21(22)15(4)28-29)18-9-8-10-24-23(18)30-7-2/h8-12,14H,6-7,13H2,1-5H3,(H,26,27) ZJGPWXQIKUCOGR-UHFFFAOYSA-N 279102 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(2-methyloxazol-5-yl)methyl]-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 133::US10512632, Example 133::US10766893, Example S133::US10806718, Example 133::US11634416, Example 133 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 11.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279102&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273428 378160687 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273002 CCCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C23H30N8O/c1-6-11-32-23-17(9-8-10-24-23)18-12-19(25-13-20-26-14-30(5)29-20)22-21(27-18)16(4)28-31(22)15(3)7-2/h8-10,12,14-15H,6-7,11,13H2,1-5H3,(H,25,27) SXNFSKBWTTYFLI-UHFFFAOYSA-N 279103 3-methyl-1-[1-methylpropyl]-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]-5-(2-propoxy-3-pyridyl)pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 134::US10512632, Example 134::US10766893, Example S134::US10806718, Example 134::US11491140, Example 134::US11634416, Example 134 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.960 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279103&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273429 378160688 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273005 CCCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(nc(C)c2n1)C(C)CC 279104 3-methyl-1-[1-methylpropyl]-5-(2-propoxy-3-pyridyl)-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 135::US10512632, Example 135::US10766893, Example S135::US10806718, Example 135::US11491140, Example 135::US11634416, Example 135 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.90 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279104&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273430 378160689 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273008 CCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(ncc2n1)C(C)CC 279105 5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine, enantiomer 1::US10034861, Example 136::US10034861, Example 137::US10512632, Example 137::US10766893, Example S137::US10806718, Example 137::US11026923, Example 137::US11491140, Example 137::US11634416, Example 137 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 62.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279105&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273431 378160690 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273011 CCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(ncc2n1)C(C)CC 279105 5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine, enantiomer 1::US10034861, Example 136::US10034861, Example 137::US10512632, Example 137::US10766893, Example S137::US10806718, Example 137::US11026923, Example 137::US11491140, Example 137::US11634416, Example 137 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 180 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279105&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273431 378160690 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273014 CCOc1ncccc1-c1cc(NCc2nnc(C)o2)c2n(ncc2n1)C(C)CC InChI=1S/C21H25N7O2/c1-5-13(3)28-20-17(23-12-19-27-26-14(4)30-19)10-16(25-18(20)11-24-28)15-8-7-9-22-21(15)29-6-2/h7-11,13H,5-6,12H2,1-4H3,(H,23,25) BIQGCKNODPBTSC-UHFFFAOYSA-N 279107 5-(2-ethoxy-3-pyridyl)-N-[(5-methyl-1,3,4-oxadiazol-2-yl)methyl]-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 138::US10034861, Example 139::US10512632, Example 139::US10766893, Example S139::US10806718, Example 139::US11026923, Example 139::US11491140, Example 139::US11634416, Example 139 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 93.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279107&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273432 378160691 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273017 CCOc1ncccc1-c1cc(NCc2nnc(C)o2)c2n(ncc2n1)C(C)CC InChI=1S/C21H25N7O2/c1-5-13(3)28-20-17(23-12-19-27-26-14(4)30-19)10-16(25-18(20)11-24-28)15-8-7-9-22-21(15)29-6-2/h7-11,13H,5-6,12H2,1-4H3,(H,23,25) BIQGCKNODPBTSC-UHFFFAOYSA-N 279107 5-(2-ethoxy-3-pyridyl)-N-[(5-methyl-1,3,4-oxadiazol-2-yl)methyl]-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 138::US10034861, Example 139::US10512632, Example 139::US10766893, Example S139::US10806718, Example 139::US11026923, Example 139::US11491140, Example 139::US11634416, Example 139 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 330 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279107&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273432 378160691 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273020 CCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(ncc2n1)C(C)CC InChI=1S/C21H26N8O/c1-5-14(3)29-20-17(23-12-19-24-13-28(4)27-19)10-16(26-18(20)11-25-29)15-8-7-9-22-21(15)30-6-2/h7-11,13-14H,5-6,12H2,1-4H3,(H,23,26) OKQUCPHNAVGTKM-UHFFFAOYSA-N 279109 5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 140::US10034861, Example 141::US10512632, Example 141::US10766893, Example S141::US10806718, Example 141::US11026923, Example 141::US11491140, Example 141::US11634416, Example 141 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 32.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279109&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273433 378160692 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273023 CCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(ncc2n1)C(C)CC InChI=1S/C21H26N8O/c1-5-14(3)29-20-17(23-12-19-24-13-28(4)27-19)10-16(26-18(20)11-25-29)15-8-7-9-22-21(15)30-6-2/h7-11,13-14H,5-6,12H2,1-4H3,(H,23,26) OKQUCPHNAVGTKM-UHFFFAOYSA-N 279109 5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 140::US10034861, Example 141::US10512632, Example 141::US10766893, Example S141::US10806718, Example 141::US11026923, Example 141::US11491140, Example 141::US11634416, Example 141 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 44.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279109&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273433 378160692 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273026 CCCOc1ncccc1-c1cc(NCc2cn(C)cn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H29N7O/c1-6-10-31-23-18(8-7-9-24-23)19-11-20(25-12-17-13-29(5)14-26-17)22-21(27-19)16(4)28-30(22)15(2)3/h7-9,11,13-15H,6,10,12H2,1-5H3,(H,25,27) KLLVPOPJMWWQFO-UHFFFAOYSA-N 279111 1-isopropyl-3-methyl-N-[(1-methylimidazol-4-yl)methyl]-5-(2-propoxy-3-pyridyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 142::US10512632, Example 142::US10766893, Example S142::US10806718, Example 142::US11491140, Example 142::US11634416, Example 142 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.260 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279111&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273434 378160693 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273029 CCCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H27N7O/c1-5-11-30-22-17(7-6-9-23-22)18-12-19(24-13-16-8-10-25-27-16)21-20(26-18)15(4)28-29(21)14(2)3/h6-10,12,14H,5,11,13H2,1-4H3,(H,24,26)(H,25,27) WVFCCHYAETYKIF-UHFFFAOYSA-N 279112 1-isopropyl-3-methyl-5-(2-propoxy-3-pyridyl)-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 143::US10512632, Example 143::US10766893, Example S143::US10806718, Example 143::US11026923, Example 143::US11491140, Example 143::US11634416, Example 143 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 3.80 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279112&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273435 378160694 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273032 CCOc1ncccc1-c1cc(NCc2nc[nH]n2)c2n(nc(C)c2n1)C(C)CC 279113 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]-N-(1H-1,2,4-triazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 144::US10512632, Example 144::US10766893, Example S144::US10806718, Example 144::US11026923, Example 144::US11491140, Example 144::US11634416, Example 144 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 14.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279113&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273438 378160695 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273035 CCCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H28N8O/c1-6-10-31-22-16(8-7-9-23-22)17-11-18(24-12-19-25-13-29(5)28-19)21-20(26-17)15(4)27-30(21)14(2)3/h7-9,11,13-14H,6,10,12H2,1-5H3,(H,24,26) ROWMNTAKQCZGNZ-UHFFFAOYSA-N 279114 1-isopropyl-3-methyl-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]-5-(2-propoxy-3-pyridyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 145::US10512632, Example 145::US10766893, Example S145::US10806718, Example 145::US11026923, Example 145::US11491140, Example 145::US11634416, Example 145 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.410 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279114&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273436 378160696 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273038 CCCOc1ncccc1-c1cc(NCc2nc[nH]n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-5-9-30-21-15(7-6-8-22-21)16-10-17(23-11-18-24-12-25-27-18)20-19(26-16)14(4)28-29(20)13(2)3/h6-8,10,12-13H,5,9,11H2,1-4H3,(H,23,26)(H,24,25,27) RLGQIPCFRYRCDL-UHFFFAOYSA-N 279115 1-isopropyl-3-methyl-5-(2-propoxy-3-pyridyl)-N-(1H-1,2,4-triazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 146::US10512632, Example 146::US10766893, Example S146::US10806718, Example 146::US11026923, Example 146::US11491140, Example 146::US11634416, Example 146 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 3.90 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279115&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273440 378160697 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273041 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1nccs1 InChI=1S/C18H21N7S/c1-11(2)25-17-14(20-8-13-9-21-24(4)10-13)7-15(18-19-5-6-26-18)22-16(17)12(3)23-25/h5-7,9-11H,8H2,1-4H3,(H,20,22) TVGMRVMYCDHOEG-UHFFFAOYSA-N 279116 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-thiazol-2-yl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 147::US10512632, Example 147::US10618913, Example S147::US10766893, Example S147::US10806718, Example 147::US11026923, Example 147::US11491140, Example 147::US11634416, Example 147 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 12.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279116&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273437 378160698 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273044 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1ncc(C)s1 InChI=1S/C19H23N7S/c1-11(2)26-18-15(20-8-14-9-22-25(5)10-14)6-16(19-21-7-12(3)27-19)23-17(18)13(4)24-26/h6-7,9-11H,8H2,1-5H3,(H,20,23) ACZBEPYVSHJPFB-UHFFFAOYSA-N 279117 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-(5-methylthiazol-2-yl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 148::US10512632, Example 148::US10766893, Example S148::US10806718, Example 148::US11026923, Example 148::US11491140, Example 148::US11634416, Example 148 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 110 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279117&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273439 378160699 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273047 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1nc(C)cs1 InChI=1S/C19H23N7S/c1-11(2)26-18-15(20-7-14-8-21-25(5)9-14)6-16(19-22-12(3)10-27-19)23-17(18)13(4)24-26/h6,8-11H,7H2,1-5H3,(H,20,23) HCLONMUJAHJFIH-UHFFFAOYSA-N 279118 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-(4-methylthiazol-2-yl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 149::US10512632, Example 149::US10766893, Example S149::US10806718, Example 149::US11026923, Example 149::US11491140, Example 149::US11634416, Example 149 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 29.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279118&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273441 378160700 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273050 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)N1CC(C)OC1=O InChI=1S/C19H25N7O2/c1-11(2)26-18-15(20-7-14-8-21-24(5)10-14)6-16(22-17(18)13(4)23-26)25-9-12(3)28-19(25)27/h6,8,10-12H,7,9H2,1-5H3,(H,20,22) YBJPEIIVVVNBPC-UHFFFAOYSA-N 279119 3-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]-5-methyl-oxazolidin-2-one::US10034861, Example 150::US10512632, Example 150::US10766893, Example S150::US10806718, Example 150::US11026923, Example 150::US11491140, Example 150::US11634416, Example 150 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 44.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279119&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273442 378160701 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273053 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)N1CCOC1=O InChI=1S/C18H23N7O2/c1-11(2)25-17-14(19-8-13-9-20-23(4)10-13)7-15(21-16(17)12(3)22-25)24-5-6-27-18(24)26/h7,9-11H,5-6,8H2,1-4H3,(H,19,21) CBOOBJUJEUVRPS-UHFFFAOYSA-N 279120 3-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]oxazolidin-2-one::US10034861, Example 151::US10512632, Example 151::US10766893, Example S151::US10806718, Example 151::US11026923, Example 151::US11491140, Example 151::US11634416, Example 151 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 10.00 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279120&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273443 378160702 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273056 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)N1CCC1=O InChI=1S/C18H23N7O/c1-11(2)25-18-14(19-8-13-9-20-23(4)10-13)7-15(24-6-5-16(24)26)21-17(18)12(3)22-25/h7,9-11H,5-6,8H2,1-4H3,(H,19,21) SLJWZSCTWDVJBR-UHFFFAOYSA-N 279121 1-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]azetidin-2-one::US10034861, Example 152::US10512632, Example 152::US10766893, Example S152::US10806718, Example 152::US11026923, Example 152::US11491140, Example 152::US11634416, Example 152 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 48.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279121&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273444 378160703 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273059 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)N1CCN(C1=O)C(C)(C)C InChI=1S/C22H32N8O/c1-14(2)30-20-17(23-11-16-12-24-27(7)13-16)10-18(25-19(20)15(3)26-30)28-8-9-29(21(28)31)22(4,5)6/h10,12-14H,8-9,11H2,1-7H3,(H,23,25) KIFHGJKUXDTDBI-UHFFFAOYSA-N 279122 1-tert-butyl-3-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]imidazolidin-2-one::US10034861, Example 153::US10512632, Example 153::US10766893, Example S153::US10806718, Example 153::US11026923, Example 153::US11491140, Example 153::US11634416, Example 153 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 130 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279122&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273445 378160704 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273062 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)N1CCCC1=O InChI=1S/C19H25N7O/c1-12(2)26-19-15(20-9-14-10-21-24(4)11-14)8-16(22-18(19)13(3)23-26)25-7-5-6-17(25)27/h8,10-12H,5-7,9H2,1-4H3,(H,20,22) CXGJWWJDXYZFFZ-UHFFFAOYSA-N 279123 1-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]pyrrolidin-2-one::US10034861, Example 154::US10512632, Example 154::US10766893, Example S154::US10806718, Example 154::US11026923, Example 154::US11491140, Example 154::US11634416, Example 154 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 26.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279123&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273446 378160705 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273065 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)N1C(C)COC1=O InChI=1S/C19H25N7O2/c1-11(2)26-18-15(20-7-14-8-21-24(5)9-14)6-16(22-17(18)13(4)23-26)25-12(3)10-28-19(25)27/h6,8-9,11-12H,7,10H2,1-5H3,(H,20,22) DXKZTPARVQEQMA-UHFFFAOYSA-N 279124 3-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]-4-methyl-oxazolidin-2-one::US10034861, Example 155::US10512632, Example 155::US10766893, Example S155::US10806718, Example 155::US11026923, Example 155::US11491140, Example 155::US11634416, Example 155 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.20 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279124&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273447 378160706 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273068 CCC1COC(=O)N1c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C20H27N7O2/c1-6-15-11-29-20(28)26(15)17-7-16(21-8-14-9-22-25(5)10-14)19-18(23-17)13(4)24-27(19)12(2)3/h7,9-10,12,15H,6,8,11H2,1-5H3,(H,21,23) CVOILQIVJFYVAQ-UHFFFAOYSA-N 279125 4-ethyl-3-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]oxazolidin-2-one::US10034861, Example 156::US10512632, Example 156::US10766893, Example S156::US10806718, Example 156::US11026923, Example 156::US11491140, Example 156::US11634416, Example 156 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 31.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279125&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273448 378160707 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273071 CCOc1ncccc1-c1cc(CNc2cncc(OC)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-20(8-7-9-26-24)21-10-17(12-27-18-11-19(31-5)14-25-13-18)23-22(28-21)16(4)29-30(23)15(2)3/h7-11,13-15,27H,6,12H2,1-5H3 BXZMPJVMGAVKJS-UHFFFAOYSA-N 279126 N-[[5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-yl]methyl]-5-methoxy-pyridin-3-amine::US10034861, Example 157::US10512632, Example 157::US10766893, Example S157::US10806718, Example 157::US11026923, Example 157::US11491140, Example 157::US11634416, Example 157 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 34.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279126&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273449 378160708 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273074 CCOc1ncccc1-c1cc(CNc2ncn(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-6-30-20-16(8-7-9-22-20)17-10-15(11-23-21-24-12-28(5)27-21)19-18(25-17)14(4)26-29(19)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,23,27) XUAILHHYTLESDG-UHFFFAOYSA-N 279127 N-[[5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-yl]methyl]-1-methyl-1,2,4-triazol-3-amine::US10034861, Example 158::US10512632, Example 158::US10766893, Example S158::US10806718, Example 158::US11026923, Example 158::US11491140, Example 158::US11634416, Example 158 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 23.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279127&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273450 378160709 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273077 CCOc1ncccc1-c1cc(CCc2cncc(OC)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C25H29N5O2/c1-6-32-25-21(8-7-11-27-25)22-13-19(10-9-18-12-20(31-5)15-26-14-18)24-23(28-22)17(4)29-30(24)16(2)3/h7-8,11-16H,6,9-10H2,1-5H3 KRADQTILGMSJGT-UHFFFAOYSA-N 279128 5-(2-ethoxy-3-pyridyl)-1-isopropyl-7-[2-(5-methoxy-3-pyridyl)ethyl]-3-methyl-pyrazolo[4,3-b]pyridine::US10034861, Example 159::US10512632, Example 159::US10766893, Example S159::US10806718, Example 159::US11026923, Example 159::US11491140, Example 159::US11634416, Example 159 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 270 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279128&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273451 378160710 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273080 CCOc1ncccc1-c1cc(CCc2ncn(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H27N7O/c1-6-30-22-17(8-7-11-23-22)18-12-16(9-10-19-24-13-28(5)27-19)21-20(25-18)15(4)26-29(21)14(2)3/h7-8,11-14H,6,9-10H2,1-5H3 DQKKFAGODSQYOO-UHFFFAOYSA-N 279129 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-7-[2-(1-methyl-1,2,4-triazol-3-yl)ethyl]pyrazolo[4,3-b]pyridine::US10034861, Example 160::US10512632, Example 160::US10766893, Example S160::US10806718, Example 160::US11026923, Example 160::US11491140, Example 160::US11634416, Example 160 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 23.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279129&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273452 378160711 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273083 CCOc1ncccc1-c1cc(NCc2ncnn2C)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-6-30-21-15(8-7-9-22-21)16-10-17(23-11-18-24-12-25-28(18)5)20-19(26-16)14(4)27-29(20)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,23,26) DSJWNAKWTOCISO-UHFFFAOYSA-N 425070 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methyl-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10512632, Example 161::US10618913, Example S161::US10766893, Example S161::US10806718, Example 161::US11026923, Example 161::US11491140, Example 162::US11634416, Example 161 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 60.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=425070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=425070&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138536279 434150493 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273086 CCOc1ncccc1-c1cc(NCc2nncn2C)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-6-30-21-15(8-7-9-22-21)16-10-17(23-11-18-26-24-12-28(18)5)20-19(25-16)14(4)27-29(20)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,23,25) XEGYXYUUSUWLRL-UHFFFAOYSA-N 279131 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(4-methyl-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 162::US10512632, Example 162::US10766893, Example S162::US11026923, Example 162::US11634416, Example 162 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 100.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279131&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273453 378160712 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273089 CCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(nc(C)c2n1)C1COC1 InChI=1S/C21H24N8O2/c1-4-31-21-15(6-5-7-22-21)16-8-17(23-9-18-24-12-28(3)27-18)20-19(25-16)13(2)26-29(20)14-10-30-11-14/h5-8,12,14H,4,9-11H2,1-3H3,(H,23,25) KHCSAUOHEOUDEI-UHFFFAOYSA-N 279132 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]-1-(oxetan-3-yl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 163::US10512632, Example 163::US10618913, Example S163::US10766893, Example S163::US10806718, Example 163::US11026923, Example 163::US11491140, Example 163::US11634416, Example 163 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 120 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279132&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273457 378160713 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273092 CCOc1ncccc1-c1cc(SCCC(=O)OCC(C)C)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H32N4O3S/c1-7-30-24-18(9-8-11-25-24)19-13-20(32-12-10-21(29)31-14-15(2)3)23-22(26-19)17(6)27-28(23)16(4)5/h8-9,11,13,15-16H,7,10,12,14H2,1-6H3 HVDCJFCTBUPVCE-UHFFFAOYSA-N 279133 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylsulfanyl]pyrazolo[4,3-b]pyridine::US10034861, Example 164::US10806718, Example 164::US11026923, Example 164::US11491140, Example 164::US11634416, Example 164 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 6.80 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279133&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273278 378160714 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273095 CCOc1ncccc1-c1cc(N(Cc2cnn(c2)C(F)F)Cc2ccc(OC)cc2)c2n(nc(C)c2n1)C(C)C InChI=1S/C30H33F2N7O2/c1-6-41-29-24(8-7-13-33-29)25-14-26(28-27(35-25)20(4)36-39(28)19(2)3)37(16-21-9-11-23(40-5)12-10-21)17-22-15-34-38(18-22)30(31)32/h7-15,18-19,30H,6,16-17H2,1-5H3 UXTFTMXAFOTATJ-UHFFFAOYSA-N 279134 N-[[1-(difluoromethyl)pyrazol-4-yl]methyl]-5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 165::US10512632, Example 165::US10618913, Example S165::US11026923, Example 165::US11491140, Example 165::US11634416, Example 165 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 73.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279134&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273284 378160715 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273098 CCOc1ncccc1-c1cc(NCc2cc(CF)on2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H25FN6O2/c1-5-30-22-17(7-6-8-24-22)18-10-19(25-12-15-9-16(11-23)31-28-15)21-20(26-18)14(4)27-29(21)13(2)3/h6-10,13H,5,11-12H2,1-4H3,(H,25,26) XUHFADCPGYKQAR-UHFFFAOYSA-N 279135 5-(2-ethoxy-3-pyridyl)-N-[[5-(fluoromethyl)isoxazol-3-yl]methyl]-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::BDBM425076::US10034861, Example 166::US10512632, Example 166::US10766893, Example S166::US10806718, Example 166::US11026923, Example 166::US11491140, Example 166::US11634416, Example 166 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.10 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279135&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273459 378160716 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273101 CCOc1ncccc1-c1cc(NCc2cc(CF)no2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H25FN6O2/c1-5-30-22-17(7-6-8-24-22)18-10-19(25-12-16-9-15(11-23)28-31-16)21-20(26-18)14(4)27-29(21)13(2)3/h6-10,13H,5,11-12H2,1-4H3,(H,25,26) VTULNMARMGUDCN-UHFFFAOYSA-N 279136 5-(2-ethoxy-3-pyridyl)-N-[[3-(fluoromethyl)isoxazol-5-yl]methyl]-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 167::US10766893, Example S167::US10806718, Example 167::US11026923, Example 167::US11491140, Example 167::US11634416, Example 167 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 11.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279136&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273460 378160717 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273104 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1ncco1 InChI=1S/C18H21N7O/c1-11(2)25-17-14(20-8-13-9-21-24(4)10-13)7-15(18-19-5-6-26-18)22-16(17)12(3)23-25/h5-7,9-11H,8H2,1-4H3,(H,20,22) IMKYKBMLZRNQRQ-UHFFFAOYSA-N 279137 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-oxazol-2-yl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 168::US10512632, Example 168::US10618913, Example S168::US10766893, Example S168::US10806718, Example 168::US11026923, Example 168::US11491140, Example 168::US11634416, Example 168 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 14.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279137&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273461 378160718 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273107 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1cnnn1C InChI=1S/C18H23N9/c1-11(2)27-18-15(19-7-13-8-21-25(4)10-13)6-14(16-9-20-24-26(16)5)22-17(18)12(3)23-27/h6,8-11H,7H2,1-5H3,(H,19,22) YPYKZBZKFWCVCN-UHFFFAOYSA-N 279138 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-(3-methyltriazol-4-yl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 169::US10512632, Example 169::US10618913, Example S169::US10766893, Example S169::US10806718, Example 169::US11026923, Example 169::US11491140, Example 169::US11634416, Example 169 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 610 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279138&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273462 378160719 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273110 COc1ncccc1-c1cc(NCc2cccnc2C(F)(F)F)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H23F3N6O/c1-13(2)32-20-18(29-12-15-7-5-9-27-21(15)23(24,25)26)11-17(30-19(20)14(3)31-32)16-8-6-10-28-22(16)33-4/h5-11,13H,12H2,1-4H3,(H,29,30) GLFDPBHOMZCMEF-UHFFFAOYSA-N 279139 1-isopropyl-5-(2-methoxy-3-pyridyl)-3-methyl-N-[[2-(trifluoromethyl)-3-pyridyl]methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 170::US10512632, Example 170::US10766893, Example S170::US10806718, Example 170::US11026923, Example 170::US11491140, Example 170::US11634416, Example 170 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 42.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279139&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273463 378160720 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273113 COc1ncccc1CNc1cc(nc2c(C)nn(C(C)C)c12)-c1ccc[nH]c1=O InChI=1S/C22H24N6O2/c1-13(2)28-20-18(25-12-15-7-5-10-24-22(15)30-4)11-17(26-19(20)14(3)27-28)16-8-6-9-23-21(16)29/h5-11,13H,12H2,1-4H3,(H,23,29)(H,25,26) YJCZMNIYQABZMT-UHFFFAOYSA-N 279140 3-[1-isopropyl-7-[(2-methoxy-3-pyridyl)methylamino]-3-methyl-pyrazolo[4,3-b]pyridin-5-yl]-1H-pyridin-2-one::US10034861, Example 171::US10512632, Example 171::US10766893, Example S171::US10806718, Example 171::US11026923, Example 171::US11491140, Example 171::US11634416, Example 171 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 290 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279140 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279140&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 136214892 378160721 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273116 CCOc1ncccc1-c1cc(NCc2ccncc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(8-7-10-26-24)19-12-20(27-13-17-9-11-25-14-21(17)31-5)23-22(28-19)16(4)29-30(23)15(2)3/h7-12,14-15H,6,13H2,1-5H3,(H,27,28) ZDNREOIUOKDWKN-UHFFFAOYSA-N 425081 US10512632, Example 172::US10766893, Example S172::US10806718, Example 172::US11026923, Example 172::US11491140, Example 172::US11634416, Example 172 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 40.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=425081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=425081&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138535948 434150496 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273119 COc1ncccc1-c1cc(NCc2cnc(C)s2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H24N6OS/c1-12(2)27-20-18(24-11-15-10-23-14(4)29-15)9-17(25-19(20)13(3)26-27)16-7-6-8-22-21(16)28-5/h6-10,12H,11H2,1-5H3,(H,24,25) SVOMGFJYTSFSPH-UHFFFAOYSA-N 279142 1-isopropyl-5-(2-methoxy-3-pyridyl)-3-methyl-N-[(2-methylthiazol-5-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 173::US10512632, Example 173::US10766893, Example S173::US11026923, Example 173::US11491140, Example 173::US11634416, Example 173 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 49.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279142&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273465 378160722 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273122 COc1ncccc1CNc1cc(nc2c(C)nn(C(C)C)c12)-c1cccnc1OC1CC1 InChI=1S/C25H28N6O2/c1-15(2)31-23-21(28-14-17-7-5-11-26-24(17)32-4)13-20(29-22(23)16(3)30-31)19-8-6-12-27-25(19)33-18-9-10-18/h5-8,11-13,15,18H,9-10,14H2,1-4H3,(H,28,29) QLFKDVQWAWXRKU-UHFFFAOYSA-N 279143 5-(2-cyclopropoxypyridin-3-yl)-1-isopropyl-N-((2-methoxypyridin-3-yl)methyl)-3-methyl-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 174::US10512632, Example 174::US10766893, Example S174::US10806718, Example 174::US11026923, Example 174::US11491140, Example 174::US11634416, Example 174 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 18.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279143 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279143&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273466 378160723 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273125 COc1ncccc1CNc1cc(nc2c(C)nn(C(C)C)c12)-c1ccnn1C InChI=1S/C21H25N7O/c1-13(2)28-20-17(23-12-15-7-6-9-22-21(15)29-5)11-16(18-8-10-24-27(18)4)25-19(20)14(3)26-28/h6-11,13H,12H2,1-5H3,(H,23,25) CROUXODBTXNMIZ-UHFFFAOYSA-N 279144 1-isopropyl-N-((2-methoxypyridin-3-yl)methyl)-3-methyl-5-(1-methyl-1H-pyrazol-5-yl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 175::US10512632, Example 175::US10766893, Example S175::US10806718, Example 175::US11026923, Example 175::US11491140, Example 175::US11634416, Example 175 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 83.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279144&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273467 378160724 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273128 CCOc1ncccc1-c1cc(NCc2ncc(OC)cn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O2/c1-6-32-23-17(8-7-9-24-23)18-10-19(25-13-20-26-11-16(31-5)12-27-20)22-21(28-18)15(4)29-30(22)14(2)3/h7-12,14H,6,13H2,1-5H3,(H,25,28) NLZDQEYNQWGPGP-UHFFFAOYSA-N 279145 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(5-methoxypyrimidin-2-yl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 176::US10512632, Example 176::US10766893, Example S176::US10806718, Example 176::US11026923, Example 176::US11491140, Example 176::US11634416, Example 176 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 81.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279145&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273468 378160725 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273131 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1ccc[nH]c1=O InChI=1S/C20H23N7O/c1-12(2)27-19-17(22-9-14-10-23-26(4)11-14)8-16(24-18(19)13(3)25-27)15-6-5-7-21-20(15)28/h5-8,10-12H,9H2,1-4H3,(H,21,28)(H,22,24) ZZXWQIDOSVIHIM-UHFFFAOYSA-N 279146 3-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]-1H-pyridin-2-one::US10034861, Example 177::US10512632, Example 177::US10766893, Example S177::US10806718, Example 177::US11026923, Example 177::US11491140, Example 177::US11634416, Example 177 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 130 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279146&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 136214893 378160726 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273134 CCOc1ncccc1-c1cc(NCc2cccnc2C(F)F)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H26F2N6O/c1-5-33-24-17(9-7-11-28-24)18-12-19(22-20(30-18)15(4)31-32(22)14(2)3)29-13-16-8-6-10-27-21(16)23(25)26/h6-12,14,23H,5,13H2,1-4H3,(H,29,30) IRSHUSVLDQPATB-UHFFFAOYSA-N 279147 N-[[2-(difluoromethyl)-3-pyridyl]methyl]-5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 178::US10512632, Example 178::US10766893, Example S178::US10806718, Example 178::US11026923, Example 178::US11491140, Example 178::US11634416, Example 178 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 31.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279147&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273469 378160727 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273137 CCOc1ncccc1-c1cc(NCc2cc(OC)ncn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O2/c1-6-32-23-17(8-7-9-24-23)18-11-19(25-12-16-10-20(31-5)27-13-26-16)22-21(28-18)15(4)29-30(22)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,25,28) RTCQCKBUFIYEDZ-UHFFFAOYSA-N 279148 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(6-methoxypyrimidin-4-yl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 179::US10512632, Example 179::US10766893, Example S179::US10806718, Example 179::US11026923, Example 179::US11491140, Example 179::US11634416, Example 179 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.80 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279148&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273471 378160728 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273140 CCOc1ncccc1-c1cc(NCc2cccnc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(10-8-12-26-24)19-13-20(27-14-17-9-7-11-25-23(17)31-5)22-21(28-19)16(4)29-30(22)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) LOZUTDKVJLMDTB-UHFFFAOYSA-N 279055 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 172::US10034861, Example 180::US10034861, Example 181::US10034861, Example 182::US10034861, Example 86::US10512632, Example 86::US10766893, Example S86::US10806718, Example 182::US11026923, Example 182::US11491140, Example 86::US11634416, Example 86 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 27.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279055&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273386 378160643 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273143 CCOc1ncccc1-c1cc(NCc2cccnc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(10-8-12-26-24)19-13-20(27-14-17-9-7-11-25-23(17)31-5)22-21(28-19)16(4)29-30(22)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) LOZUTDKVJLMDTB-UHFFFAOYSA-N 279055 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 172::US10034861, Example 180::US10034861, Example 181::US10034861, Example 182::US10034861, Example 86::US10512632, Example 86::US10766893, Example S86::US10806718, Example 182::US11026923, Example 182::US11491140, Example 86::US11634416, Example 86 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 31.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279055&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273386 378160643 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273146 CCOc1ncccc1-c1cc(NCc2cccnc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(10-8-12-26-24)19-13-20(27-14-17-9-7-11-25-23(17)31-5)22-21(28-19)16(4)29-30(22)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) LOZUTDKVJLMDTB-UHFFFAOYSA-N 279055 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 172::US10034861, Example 180::US10034861, Example 181::US10034861, Example 182::US10034861, Example 86::US10512632, Example 86::US10766893, Example S86::US10806718, Example 182::US11026923, Example 182::US11491140, Example 86::US11634416, Example 86 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 24.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279055&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273386 378160643 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273149 COc1ncccc1CNc1cc(nc2c(C)nn(C(C)C)c12)-c1cccnc1C(F)(F)F InChI=1S/C23H23F3N6O/c1-13(2)32-20-18(29-12-15-7-5-10-28-22(15)33-4)11-17(30-19(20)14(3)31-32)16-8-6-9-27-21(16)23(24,25)26/h5-11,13H,12H2,1-4H3,(H,29,30) AAAZUNCZBZHDPM-UHFFFAOYSA-N 279152 1-isopropyl-N-((2-methoxypyridin-3-yl)methyl)-3-methyl-5-(2-(trifluoromethyl)pyridin-3-yl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 183::US10512632, Example 183::US10766893, Example S183::US10806718, Example 183::US11634416, Example 183 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 290 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279152&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273472 378160729 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273152 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C(F)F)c2n1)C(C)C InChI=1S/C22H25F2N7O/c1-5-32-22-15(7-6-8-25-22)16-9-17(26-10-14-11-27-30(4)12-14)20-18(28-16)19(21(23)24)29-31(20)13(2)3/h6-9,11-13,21H,5,10H2,1-4H3,(H,26,28) YFAHCXPQQYYPCW-UHFFFAOYSA-N 279153 3-(difluoromethyl)-5-(2-ethoxypyridin-3-yl)-1-isopropyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 184::US10512632, Example 184::US10618913, Example S184::US10766893, Example S184::US10806718, Example 184::US11491140, Example 184::US11634416, Example 184 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 13.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279153&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273473 378160730 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273155 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-n1cncn1 InChI=1S/C17H21N9/c1-11(2)26-17-14(19-6-13-7-20-24(4)8-13)5-15(25-10-18-9-21-25)22-16(17)12(3)23-26/h5,7-11H,6H2,1-4H3,(H,19,22) VELNJFTUSCXPKE-UHFFFAOYSA-N 279154 1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-5-(1H-1,2,4-triazol-1-yl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 185::US10512632, Example 185::US10766893, Example S185::US10806718, Example 185::US11026923, Example 185::US11491140, Example 185::US11634416, Example 185 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 100.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279154&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273474 378160731 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273158 CC(C)n1nc(C)c2nc(cc(NCc3ncn(C)n3)c12)-c1ccc[nH]c1=O InChI=1S/C19H22N8O/c1-11(2)27-18-15(21-9-16-22-10-26(4)25-16)8-14(23-17(18)12(3)24-27)13-6-5-7-20-19(13)28/h5-8,10-11H,9H2,1-4H3,(H,20,28)(H,21,23) LRKYMHYCQWOGDT-UHFFFAOYSA-N 279155 3-[1-isopropyl-3-methyl-7-[(1-methyl-1,2,4-triazol-3-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]-1H-pyridin-2-one::US10034861, Example 186::US10512632, Example 186::US10766893, Example S186::US10806718, Example 186::US11026923, Example 186::US11491140, Example 186::US11634416, Example 186 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 64.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279155&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 136214894 378160732 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273161 CC(C)n1nc(C)c2nc(cc(NCc3cc[nH]n3)c12)-c1ccc[nH]c1=O InChI=1S/C19H21N7O/c1-11(2)26-18-16(21-10-13-6-8-22-24-13)9-15(23-17(18)12(3)25-26)14-5-4-7-20-19(14)27/h4-9,11H,10H2,1-3H3,(H,20,27)(H,21,23)(H,22,24) FWAXXZSYYYRIBS-UHFFFAOYSA-N 279156 3-[1-isopropyl-3-methyl-7-(1H-pyrazol-3-ylmethylamino)pyrazolo[4,3-b]pyridin-5-yl]-1H-pyridin-2-one::US10034861, Example 187::US10512632, Example 187::US10766893, Example S187::US10806718, Example 187::US11026923, Example 187::US11491140, Example 187::US11634416, Example 187 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 140 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279156&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 136214895 378160733 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273164 COc1ncccc1CNc1cc(nc2c(C)nn(C(C)C)c12)-c1cccnc1OC(F)F InChI=1S/C23H24F2N6O2/c1-13(2)31-20-18(28-12-15-7-5-9-26-21(15)32-4)11-17(29-19(20)14(3)30-31)16-8-6-10-27-22(16)33-23(24)25/h5-11,13,23H,12H2,1-4H3,(H,28,29) HFYVDFFGOVRRIK-UHFFFAOYSA-N 279157 5-[2-(difluoromethoxy)-3-pyridyl]-1-isopropyl-N-[(2-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 188::US10512632, Example 188::US10766893, Example S188::US11026923, Example 188::US11491140, Example 188::US11634416, Example 188 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 61.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279157&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273478 378160734 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273167 CCOc1ncccc1-c1cc(NCc2nccc(OC)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O2/c1-6-32-23-16(8-7-10-25-23)17-12-18(26-13-19-24-11-9-20(28-19)31-5)22-21(27-17)15(4)29-30(22)14(2)3/h7-12,14H,6,13H2,1-5H3,(H,26,27) ZRCQWXKCYCHOGM-UHFFFAOYSA-N 279158 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(4-methoxypyrimidin-2-yl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 189::US10512632, Example 189::US10766893, Example S189::US10806718, Example 189::US11026923, Example 189::US11491140, Example 189::US11634416, Example 189 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 3.90 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279158&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273477 378160735 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273170 CCOc1ncccc1-c1cc(NCc2cncnc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O2/c1-6-32-23-17(8-7-9-25-23)18-10-19(26-12-16-11-24-13-27-22(16)31-5)21-20(28-18)15(4)29-30(21)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,26,28) FQSCOMBJMAVYMG-UHFFFAOYSA-N 279159 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(4-methoxypyrimidin-5-yl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 190::US10512632, Example 190::US10766893, Example S190::US10806718, Example 190::US11026923, Example 190::US11491140, Example 190::US11634416, Example 190 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 74.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279159&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273480 378160736 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273173 CCOc1ncccc1CNc1cc(nc2c(C)nn(C(C)C)c12)-c1cccnc1OCC InChI=1S/C25H30N6O2/c1-6-32-24-18(10-8-12-26-24)15-28-21-14-20(19-11-9-13-27-25(19)33-7-2)29-22-17(5)30-31(16(3)4)23(21)22/h8-14,16H,6-7,15H2,1-5H3,(H,28,29) RPFGIRQWMRKNBU-UHFFFAOYSA-N 279160 5-(2-ethoxy-3-pyridyl)-N-[(2-ethoxy-3-pyridyl)methyl]-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 191::US10512632, Example 191::US10766893, Example S191::US10806718, Example 191::US11026923, Example 191::US11491140, Example 191::US11634416, Example 191 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 160 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279160&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273479 378160737 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273176 COc1ccc(CNc2cc(nc3c(C)nn(C(C)C)c23)-c2cccnc2N(C)C)cc1 InChI=1S/C25H30N6O/c1-16(2)31-24-22(27-15-18-9-11-19(32-6)12-10-18)14-21(28-23(24)17(3)29-31)20-8-7-13-26-25(20)30(4)5/h7-14,16H,15H2,1-6H3,(H,27,28) RMYFPLHNAGFJMC-UHFFFAOYSA-N 279161 5-[2-(dimethylamino)-3-pyridyl]-1-isopropyl-N-[(4-methoxyphenyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 192::US10512632, Example 192::US10766893, Example S192::US10806718, Example 192::US11026923, Example 192::US11491140, Example 192::US11634416, Example 192 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 630 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279161&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273481 378160738 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273179 CC(C)n1nc(C)c2nc(cc(NCc3cccnc3C(F)(F)F)c12)-c1ccc[nH]c1=O InChI=1S/C22H21F3N6O/c1-12(2)31-19-17(28-11-14-6-4-8-26-20(14)22(23,24)25)10-16(29-18(19)13(3)30-31)15-7-5-9-27-21(15)32/h4-10,12H,11H2,1-3H3,(H,27,32)(H,28,29) CEASKHHYUJNGEA-UHFFFAOYSA-N 279162 3-[1-isopropyl-3-methyl-7-[[2-(trifluoromethyl)-3-pyridyl]methylamino]pyrazolo[4,3-b]pyridin-5-yl]-1H-pyridin-2-one::US10034861, Example 193::US10512632, Example 193::US10766893, Example S193::US10806718, Example 193::US11491140, Example 193::US11634416, Example 193 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 320 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279162&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 136214896 378160739 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273182 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1conc1C InChI=1S/C19H23N7O/c1-11(2)26-19-17(20-7-14-8-21-25(5)9-14)6-16(15-10-27-24-12(15)3)22-18(19)13(4)23-26/h6,8-11H,7H2,1-5H3,(H,20,22) MTWLSLCQXJXQNM-UHFFFAOYSA-N 279163 1-isopropyl-3-methyl-5-(3-methylisoxazol-4-yl)-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 194::US10512632, Example 194::US10766893, Example S194::US10806718, Example 194::US11491140, Example 194::US11634416, Example 194 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 95.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279163&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273485 378160740 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273185 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1ncnn1C InChI=1S/C18H23N9/c1-11(2)27-17-14(19-7-13-8-21-25(4)9-13)6-15(18-20-10-22-26(18)5)23-16(17)12(3)24-27/h6,8-11H,7H2,1-5H3,(H,19,23) KYLSIDIKSXHHCI-UHFFFAOYSA-N 279164 1-isopropyl-3-methyl-5-(1-methyl-1H-1,2,4-triazol-5-yl)-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 195::US10512632, Example 195::US10618913, Example S195::US10766893, Example S195::US10806718, Example 195::US11026923, Example 195::US11634416, Example 195 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 420 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279164&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273486 378160741 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273188 CCCOc1ncccc1-c1cc(NCc2cn[nH]c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H27N7O/c1-5-9-30-22-17(7-6-8-23-22)18-10-19(24-11-16-12-25-26-13-16)21-20(27-18)15(4)28-29(21)14(2)3/h6-8,10,12-14H,5,9,11H2,1-4H3,(H,24,27)(H,25,26) FTOYLOIRXWDMMT-UHFFFAOYSA-N 279165 1-isopropyl-3-methyl-5-(2-propoxy-3-pyridyl)-N-(1H-pyrazol-4-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 196::US10512632, Example 196::US11491140, Example 196::US11634416, Example 196 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 18.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279165&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273488 378160742 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272606 CCOc1ncccc1-c1cc(NCc2nnc(C)o2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H25N7O2/c1-6-29-21-15(8-7-9-22-21)16-10-17(23-11-18-26-25-14(5)30-18)20-19(24-16)13(4)27-28(20)12(2)3/h7-10,12H,6,11H2,1-5H3,(H,23,24) XEBJMVLHZBRKST-UHFFFAOYSA-N 278971 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methyl-1,3,4-oxadiazol-2-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 1::US10512632, Example 1::US10618913, Example S1::US10766893, Example S1::US10806718, Example 1::US11026923, Example 1::US11491140, Example 1::US11634416, Example 1 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 18.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278971 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278971&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273299 378160560 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272609 CCOc1ncccc1-c1cc(NCc2ncc(C)s2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6OS/c1-6-29-22-16(8-7-9-23-22)17-10-18(24-12-19-25-11-14(4)30-19)21-20(26-17)15(5)27-28(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,24,26) QOYNQFLWGDTXKT-UHFFFAOYSA-N 278972 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methylthiazol-2-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 2::US10512632, Example 2::US10766893, Example S2::US10806718, Example 2::US11026923, Example 2::US11491140, Example 2::US11634416, Example 2 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.460 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278972 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278972&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273301 378160561 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273191 CCOc1ncccc1-c1cc(NCc2cccnc2OC)c2n(nc(C)c2n1)C1COC1 InChI=1S/C24H26N6O3/c1-4-33-24-18(8-6-10-26-24)19-11-20(27-12-16-7-5-9-25-23(16)31-3)22-21(28-19)15(2)29-30(22)17-13-32-14-17/h5-11,17H,4,12-14H2,1-3H3,(H,27,28) GRFJYHDUOKDAKO-UHFFFAOYSA-N 279166 5-(2-ethoxy-3-pyridyl)-N-[(2-methoxy-3-pyridyl)methyl]-3-methyl-1-(oxetan-3-yl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 197::US10512632, Example 197::US10618913, Example S197::US10766893, Example S197::US10806718, Example 197::US11491140, Example 197::US11634416, Example 197 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 190 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279166&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273484 378160743 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273194 CCN(C)c1ncccc1-c1cc(NCc2ccc(OC)cc2)c2n(nc(C)c2n1)C(C)C InChI=1S/C26H32N6O/c1-7-31(5)26-21(9-8-14-27-26)22-15-23(28-16-19-10-12-20(33-6)13-11-19)25-24(29-22)18(4)30-32(25)17(2)3/h8-15,17H,7,16H2,1-6H3,(H,28,29) YNHQWVLFISTQIU-UHFFFAOYSA-N 279167 5-(2-(ethyl(methyl)amino)pyridin-3-yl)-1-isopropyl-N-(4-methoxybenzyl)-3-methyl-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 198::US10512632, Example 198::US10766893, Example S198::US10806718, Example 198::US11026923, Example 198::US11491140, Example 198::US11634416, Example 198 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1100 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279167 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279167&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273483 378160744 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273197 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(CF)c2n1)C(C)C InChI=1S/C22H26FN7O/c1-5-31-22-16(7-6-8-24-22)17-9-18(25-11-15-12-26-29(4)13-15)21-20(27-17)19(10-23)28-30(21)14(2)3/h6-9,12-14H,5,10-11H2,1-4H3,(H,25,27) CRFWOMGBISLKHY-UHFFFAOYSA-N 279168 5-(2-ethoxypyridin-3-yl)-3-(fluoromethyl)-1-isopropyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 199::US10512632, Example 199::US10618913, Example S199::US10766893, Example S199::US10806718, Example 199::US11026923, Example 199::US11491140, Example 199::US11634416, Example 199 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 7.40 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279168&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273487 378160745 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273200 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1ocnc1C InChI=1S/C19H23N7O/c1-11(2)26-18-15(20-7-14-8-22-25(5)9-14)6-16(19-13(4)21-10-27-19)23-17(18)12(3)24-26/h6,8-11H,7H2,1-5H3,(H,20,23) JVGYDVFOXCBHRN-UHFFFAOYSA-N 279169 1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-5-(4-methyloxazol-5-yl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 200::US10512632, Example 200::US10618913, Example S200::US10766893, Example S200::US10806718, Example 200::US11026923, Example 200::US11491140, Example 200::US11634416, Example 200 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 98.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279169&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273489 378160746 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273203 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1cccnc1N(C)C InChI=1S/C22H28N8/c1-14(2)30-21-19(24-11-16-12-25-29(6)13-16)10-18(26-20(21)15(3)27-30)17-8-7-9-23-22(17)28(4)5/h7-10,12-14H,11H2,1-6H3,(H,24,26) JWSSTJTVRAZILB-UHFFFAOYSA-N 279170 5-[2-(dimethylamino)-3-pyridyl]-1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 201::US10512632, Example 201::US10766893, Example S201::US10806718, Example 201::US11026923, Example 201::US11491140, Example 201::US11634416, Example 201 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2100 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279170&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273490 378160747 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273206 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1nc(C)co1 InChI=1S/C19H23N7O/c1-11(2)26-18-15(20-7-14-8-21-25(5)9-14)6-16(19-22-12(3)10-27-19)23-17(18)13(4)24-26/h6,8-11H,7H2,1-5H3,(H,20,23) GNUZZRWHGHQDMA-UHFFFAOYSA-N 279171 1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-5-(4-methyloxazol-2-yl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 202::US10512632, Example 202::US10766893, Example S202::US10806718, Example 202::US11634416, Example 202 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 92.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279171&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273491 378160748 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1273209 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1nncn1C InChI=1S/C18H23N9/c1-11(2)27-17-14(19-7-13-8-21-26(5)9-13)6-15(18-23-20-10-25(18)4)22-16(17)12(3)24-27/h6,8-11H,7H2,1-5H3,(H,19,22) KAIFDCSXZCWWKF-UHFFFAOYSA-N 279172 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-(4-methyl-1,2,4-triazol-3-::US10034861, Example 203::US10512632, Example 203::US10766893, Example S203::US10806718, Example 203::US11026923, Example 203::US11491140, Example 203::US11634416, Example 203 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 410 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279172 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279172&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273492 378160749 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272612 CCOc1ncccc1-c1cc(NCc2cc(C)on2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6O2/c1-6-29-22-17(8-7-9-23-22)18-11-19(24-12-16-10-14(4)30-27-16)21-20(25-18)15(5)26-28(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,24,25) MKELJWFWEJOZNC-UHFFFAOYSA-N 278973 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methylisoxazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 3::US10512632, Example 3::US10766893, Example S3::US10806718, Example 3::US11026923, Example 3::US11491140, Example 3::US11634416, Example 3 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.800 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278973&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273302 378160562 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272615 CCOc1ncccc1-c1cc(NCc2cnc(C)o2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6O2/c1-6-29-22-17(8-7-9-23-22)18-10-19(25-12-16-11-24-15(5)30-16)21-20(26-18)14(4)27-28(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,25,26) TWDRBTLHNZMOLP-UHFFFAOYSA-N 278974 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methyloxazol-5-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 4::US10512632, Example 4::US10766893, Example S4::US10806718, Example 4::US11026923, Example 4::US11491140, Example 4::US11634416, Example 4 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.60 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278974 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278974&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273304 378160563 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272618 CCOc1ncccc1-c1cc(NCc2cnn(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-6-30-21-16(8-7-9-22-21)17-10-18(23-11-15-12-24-28(5)27-15)20-19(25-17)14(4)26-29(20)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,23,25) RKVBYUMNPKGITG-UHFFFAOYSA-N 278975 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methyltriazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 5::US10512632, Example 5::US10766893, Example S5::US10806718, Example 5::US11026923, Example 5::US11491140, Example 5::US11634416, Example 5 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 11.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278975&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273303 378160564 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272621 CCOc1ncccc1-c1cc(NCc2cn(C)nn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-6-30-21-16(8-7-9-22-21)17-10-18(23-11-15-12-28(5)27-25-15)20-19(24-17)14(4)26-29(20)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,23,24) GZZVSCZGHCUFQG-UHFFFAOYSA-N 278976 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(1-methyltriazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 6::US10512632, Example 6::US10766893, Example S6::US10806718, Example 6::US11026923, Example 6::US11491140, Example 6::US11634416, Example 6 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4.80 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278976&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273306 378160565 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272624 CCOc1ncccc1-c1cc(NCc2cn[nH]c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H25N7O/c1-5-29-21-16(7-6-8-22-21)17-9-18(23-10-15-11-24-25-12-15)20-19(26-17)14(4)27-28(20)13(2)3/h6-9,11-13H,5,10H2,1-4H3,(H,23,26)(H,24,25) ZBYZXMQLZZULRF-UHFFFAOYSA-N 278977 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1H-pyrazol-4-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 7::US10512632, Example 7::US10766893, Example S7::US10806718, Example 7::US11026923, Example 7::US11491140, Example 7::US11634416, Example 7 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 21.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278977 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278977&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 136214891 378160566 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272627 CCOc1ncccc1-c1cc(NCc2nnn(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C20H25N9O/c1-6-30-20-14(8-7-9-21-20)15-10-16(22-11-17-24-27-28(5)26-17)19-18(23-15)13(4)25-29(19)12(2)3/h7-10,12H,6,11H2,1-5H3,(H,22,23) MMFBNAADCPOKBP-UHFFFAOYSA-N 278978 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methyltetrazol-5-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 8::US10512632, Example 8::US10766893, Example S8::US10806718, Example 8::US11491140, Example 8::US11634416, Example 8 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.90 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278978&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273308 378160567 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272630 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H27N7O/c1-6-30-22-17(8-7-9-23-22)18-10-19(24-11-16-12-25-28(5)13-16)21-20(26-18)15(4)27-29(21)14(2)3/h7-10,12-14H,6,11H2,1-5H3,(H,24,26) IGZQEXMDAKABFO-UHFFFAOYSA-N 278979 5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 9::US10512632, Example 9::US10766893, Example S9::US10806718, Example 9::US11491140, Example 9::US11634416, Example 9 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.60 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278979&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273307 378160568 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272633 CCOc1ncccc1-c1cc(NCc2cc(C)no2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6O2/c1-6-29-22-17(8-7-9-23-22)18-11-19(24-12-16-10-14(4)27-30-16)21-20(25-18)15(5)26-28(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,24,25) WAUSGEZRVANNBG-UHFFFAOYSA-N 278980 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(3-methylisoxazol-5-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 10::US10512632, Example 10::US10766893, Example S10::US10806718, Example 10::US11491140, Example 10::US11634416, Example 10 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4.10 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278980 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278980&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273310 378160569 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272636 CCOc1ncccc1-c1cc(NCc2csc(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6OS/c1-6-29-22-17(8-7-9-23-22)18-10-19(24-11-16-12-30-15(5)25-16)21-20(26-18)14(4)27-28(21)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,24,26) YDCVOKZJZPJMKM-UHFFFAOYSA-N 278981 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methylthiazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 11::US10512632, Example 11::US10766893, Example S11::US10806718, Example 11::US11491140, Example 11::US11634416, Example 11 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 9.60 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278981&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273309 378160570 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272639 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c(NC2CC2)c(n1)C(C)=N InChI=1S/C22H27N7O/c1-4-30-22-17(6-5-9-24-22)18-10-19(25-11-15-12-26-29(3)13-15)21(27-16-7-8-16)20(28-18)14(2)23/h5-6,9-10,12-13,16,23,27H,4,7-8,11H2,1-3H3,(H,25,28) NYYKSMYMZPDEJH-UHFFFAOYSA-N 601398 1-cyclopropyl-5-(2-ethoxy-3-pyridyl)-3-methyl-N- [(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3- b]pyridin-7-amine::US11634416, Example 12 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 200 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601398&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 155028607 482092492 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272642 CCCn1ncc2nc(cc(NCc3cnn(C)c3)c12)-c1cccnc1OCC InChI=1S/C21H25N7O/c1-4-9-28-20-18(23-11-15-12-24-27(3)14-15)10-17(26-19(20)13-25-28)16-7-6-8-22-21(16)29-5-2/h6-8,10,12-14H,4-5,9,11H2,1-3H3,(H,23,26) VBBYLKGVLRZVDT-UHFFFAOYSA-N 278983 5-(2-ethoxy-3-pyridyl)-N-[(1-methylpyrazol-4-yl)methyl]-1-propyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 13::US10512632, Example 13::US10618913, Example S13::US10766893, Example S13::US10806718, Example 13::US11026923, Example 13::US11491140, Example 13::US11634416, Example 13 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 90.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278983 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278983&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273312 378160572 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272645 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(ncc2n1)C1COC1 InChI=1S/C21H23N7O2/c1-3-30-21-16(5-4-6-22-21)17-7-18(23-8-14-9-24-27(2)11-14)20-19(26-17)10-25-28(20)15-12-29-13-15/h4-7,9-11,15H,3,8,12-13H2,1-2H3,(H,23,26) BRAWZTIBDHEBNS-UHFFFAOYSA-N 278984 5-(2-ethoxypyridin-3-yl)-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1-(oxetan-3-yl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 14::US10512632, Example 14::US10618913, Example S14::US10766893, Example S14::US10806718, Example 14::US11026923, Example 14::US11491140, Example 14::US11634416, Example 14 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 450 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278984 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278984&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273313 378160573 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272648 CCOc1ncccc1-c1cc(NC(C)c2cnn(C)c2)c(NC)c(C=N)n1 InChI=1S/C20H25N7O/c1-5-28-20-15(7-6-8-23-20)16-9-17(19(22-3)18(10-21)26-16)25-13(2)14-11-24-27(4)12-14/h6-13,21-22H,5H2,1-4H3,(H,25,26) YHCUGGXMFMKHID-UHFFFAOYSA-N 601401 5-(2-ethoxypyridin-3-yl)-1-methyl-N-(1-(1-methyl- 1H-pyrazol-4-yl)ethyl)-1H-pyrazolo[4,3-b]pyridin- 7-amine (racemic)::US11634416, Example 15 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 820 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601401 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601401&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 146420737 482092495 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272651 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c(NC)c(C=N)n1 InChI=1S/C19H23N7O/c1-4-27-19-14(6-5-7-22-19)15-8-16(18(21-2)17(9-20)25-15)23-10-13-11-24-26(3)12-13/h5-9,11-12,20-21H,4,10H2,1-3H3,(H,23,25) YWZGIRPKPNRMEV-UHFFFAOYSA-N 601402 5-(2-ethoxypyridin-3-yl)-1-methyl-N-((1-methyl- 1H-pyrazol-4-yl)methyl)-1H-pyrazolo[4,3- b]pyridin-7-amine::US11634416, Example 16 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 670 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601402 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601402&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 155647869 482092496 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272654 CCOc1ncccc1-c1cc(NCc2nccn2C)c2n(ncc2n1)C(C)C InChI=1S/C21H25N7O/c1-5-29-21-15(7-6-8-23-21)16-11-17(24-13-19-22-9-10-27(19)4)20-18(26-16)12-25-28(20)14(2)3/h6-12,14H,5,13H2,1-4H3,(H,24,26) XRIYYPDCPKIHRW-UHFFFAOYSA-N 278987 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimidazol-2-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 17::US10512632, Example 17::US10618913, Example S17::US10766893, Example S17::US10806718, Example 17::US11026923, Example 17::US11491140, Example 17::US11634416, Example 17 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 700 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278987 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278987&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273316 378160576 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272657 CCOc1ncccc1-c1cc(NCc2ccnn2C)c2n(ncc2n1)C(C)C InChI=1S/C21H25N7O/c1-5-29-21-16(7-6-9-22-21)17-11-18(23-12-15-8-10-24-27(15)4)20-19(26-17)13-25-28(20)14(2)3/h6-11,13-14H,5,12H2,1-4H3,(H,23,26) ARZYUJKMHFQSRW-UHFFFAOYSA-N 278988 5-(2-ethoxypyridin-3-yl)-1-isopropyl-N-((1-methyl-1H-pyrazol-5-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 18::US10512632, Example 18::US10766893, Example S18::US10806718, Example 18::US11026923, Example 18::US11491140, Example 18::US11634416, Example 18 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 450 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278988&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273317 378160577 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272660 CCOc1ncccc1-c1cc(NCc2ccn(C)n2)c2n(ncc2n1)C(C)C InChI=1S/C21H25N7O/c1-5-29-21-16(7-6-9-22-21)17-11-18(23-12-15-8-10-27(4)26-15)20-19(25-17)13-24-28(20)14(2)3/h6-11,13-14H,5,12H2,1-4H3,(H,23,25) KZFYUJZMDBTCDC-UHFFFAOYSA-N 278989 5-(2-ethoxypyridin-3-yl)-1-isopropyl-N-((1-methyl-1H-pyrazol-3-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 19::US10512632, Example 19::US10766893, Example S19::US10806718, Example 19::US11026923, Example 19::US11491140, Example 19::US11634416, Example 19 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 66.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278989 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278989&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273318 378160578 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272663 CCOc1ncccc1-c1cc(NCc2nccs2)c2n(ncc2n1)C(C)C InChI=1S/C20H22N6OS/c1-4-27-20-14(6-5-7-22-20)15-10-16(23-12-18-21-8-9-28-18)19-17(25-15)11-24-26(19)13(2)3/h5-11,13H,4,12H2,1-3H3,(H,23,25) ICTYYJZHJNSZFG-UHFFFAOYSA-N 278990 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-(thiazol-2-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 20::US10512632, Example 20::US10766893, Example S20::US10806718, Example 20::US11026923, Example 20::US11491140, Example 20::US11634416, Example 20 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 520 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278990&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273319 378160579 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272666 CCOc1ncccc1-c1cc(NCc2cn(C)cn2)c2n(ncc2n1)C(C)C InChI=1S/C21H25N7O/c1-5-29-21-16(7-6-8-22-21)17-9-18(23-10-15-12-27(4)13-24-15)20-19(26-17)11-25-28(20)14(2)3/h6-9,11-14H,5,10H2,1-4H3,(H,23,26) GPZPPQFWVLHHBU-UHFFFAOYSA-N 278991 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimidazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 21::US10512632, Example 21::US10766893, Example S21::US10806718, Example 21::US11026923, Example 21::US11491140, Example 21::US11634416, Example 21 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.90 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278991&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273320 378160580 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272669 CCOc1ncccc1-c1cc(NCc2ccncc2)c2n(ncc2n1)C(C)C InChI=1S/C22H24N6O/c1-4-29-22-17(6-5-9-24-22)18-12-19(25-13-16-7-10-23-11-8-16)21-20(27-18)14-26-28(21)15(2)3/h5-12,14-15H,4,13H2,1-3H3,(H,25,27) HEERUKANWGHTOL-UHFFFAOYSA-N 278992 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-(4-pyridylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 22::US10512632, Example 22::US10766893, Example S22::US10806718, Example 22::US11026923, Example 22::US11491140, Example 22::US11634416, Example 22 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 250 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278992&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273322 378160581 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272672 CCOc1ncccc1-c1cc(NCc2cccc(C)c2)c2n(ncc2n1)C(C)C InChI=1S/C24H27N5O/c1-5-30-24-19(10-7-11-25-24)20-13-21(26-14-18-9-6-8-17(4)12-18)23-22(28-20)15-27-29(23)16(2)3/h6-13,15-16H,5,14H2,1-4H3,(H,26,28) NOGPVEPEDSPNHF-UHFFFAOYSA-N 278993 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-(m-tolylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 23::US10512632, Example 23::US10618913, Example S23::US10766893, Example S23::US10806718, Example 23::US11026923, Example 23::US11491140, Example 23::US11634416, Example 23 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 240 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278993&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273321 378160582 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272675 CCOc1ncccc1-c1cc(NCc2ccc(C)cc2)c2n(ncc2n1)C(C)C InChI=1S/C24H27N5O/c1-5-30-24-19(7-6-12-25-24)20-13-21(26-14-18-10-8-17(4)9-11-18)23-22(28-20)15-27-29(23)16(2)3/h6-13,15-16H,5,14H2,1-4H3,(H,26,28) KLXXAXDPPNWJOU-UHFFFAOYSA-N 278994 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-(p-tolylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 24::US10512632, Example 24::US10766893, Example S24::US10806718, Example 24::US11026923, Example 24::US11491140, Example 24::US11634416, Example 24 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 380 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278994&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273323 378160583 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272678 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(ncc2n1)C(C)C InChI=1S/C21H25N7O/c1-5-29-21-16(7-6-8-22-21)17-9-18(23-10-15-11-24-27(4)13-15)20-19(26-17)12-25-28(20)14(2)3/h6-9,11-14H,5,10H2,1-4H3,(H,23,26) PLERDTYSXFBCOL-UHFFFAOYSA-N 278995 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 25::US10512632, Example 25::US10766893, Example S25::US10806718, Example 25::US11026923, Example 25::US11491140, Example 25::US11634416, Example 25 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 56.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278995&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273324 378160584 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272681 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(CC)ncc2n1 InChI=1S/C20H23N7O/c1-4-27-19-17(22-10-14-11-23-26(3)13-14)9-16(25-18(19)12-24-27)15-7-6-8-21-20(15)28-5-2/h6-9,11-13H,4-5,10H2,1-3H3,(H,22,25) GDQVLYVPAWKIKI-UHFFFAOYSA-N 424936 US10512632, Example 26::US10618913, Example S26::US10766893, Example S26::US10806718, Example 26::US11026923, Example 26::US11491140, Example 26::US11634416, Example 26 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 140 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=424936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=424936&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138536209 434150491 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272684 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C1COC1 InChI=1S/C22H25N7O2/c1-4-31-22-17(6-5-7-23-22)18-8-19(24-9-15-10-25-28(3)11-15)21-20(26-18)14(2)27-29(21)16-12-30-13-16/h5-8,10-11,16H,4,9,12-13H2,1-3H3,(H,24,26) HKTCICUQHUTDJM-UHFFFAOYSA-N 278997 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-1-(oxetan-3-yl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 27::US10512632, Example 27::US10766893, Example S27::US10806718, Example 27::US11026923, Example 27::US11491140, Example 27::US11634416, Example 27 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 94.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278997 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278997&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273326 378160586 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272687 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(C)nc(C)c2n1 InChI=1S/C20H23N7O/c1-5-28-20-15(7-6-8-21-20)16-9-17(22-10-14-11-23-26(3)12-14)19-18(24-16)13(2)25-27(19)4/h6-9,11-12H,5,10H2,1-4H3,(H,22,24) GGQMHLLGYDUHDQ-UHFFFAOYSA-N 278998 5-(2-ethoxy-3-pyridyl)-1,3-dimethyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 28::US10512632, Example 28::US10618913, Example S28::US10766893, Example S28::US10806718, Example 28::US11026923, Example 28::US11491140, Example 28::US11634416, Example 28 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 550 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278998 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278998&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273327 378160587 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272690 CCOc1ncccc1-c1cc(NCc2nc(C)cs2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6OS/c1-6-29-22-16(8-7-9-23-22)17-10-18(24-11-19-25-14(4)12-30-19)21-20(26-17)15(5)27-28(21)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,24,26) WFSFSRAGPIZNCC-UHFFFAOYSA-N 278999 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(4-methylthiazol-2-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 29::US10512632, Example 29::US10618913, Example S162::US10766893, Example S29::US10806718, Example 29::US11026923, Example 29::US11491140, Example 29::US11634416, Example 29 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 27.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278999 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278999&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273328 378160588 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272693 CCOc1ncccc1-c1cc(NCc2nc(C)no2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H25N7O2/c1-6-29-21-15(8-7-9-22-21)16-10-17(23-11-18-24-14(5)27-30-18)20-19(25-16)13(4)26-28(20)12(2)3/h7-10,12H,6,11H2,1-5H3,(H,23,25) ZPMKSBYSMXCOIZ-UHFFFAOYSA-N 279000 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(3-methyl-1,2,4-oxadiazol-5-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 30::US10512632, Example 30::US10766893, Example S30::US10806718, Example 30::US11026923, Example 30::US11491140, Example 30::US11634416, Example 30 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 15.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279000 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279000&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273329 378160589 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272696 CCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-6-30-21-15(8-7-9-22-21)16-10-17(23-11-18-24-12-28(5)27-18)20-19(25-16)14(4)26-29(20)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,23,25) CJOUFKUESMXTOX-UHFFFAOYSA-N 279001 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 161::US10034861, Example 31::US10512632, Example 31::US10766893, Example S31::US10806718, Example 31::US11026923, Example 31::US11491140, Example 31::US11634416, Example 31 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.20 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279001 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279001&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273330 378160590 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272699 CCOc1ncccc1-c1cc(NCc2cnc(C)s2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6OS/c1-6-29-22-17(8-7-9-23-22)18-10-19(25-12-16-11-24-15(5)30-16)21-20(26-18)14(4)27-28(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,25,26) UJFBEAPRUYBIKE-UHFFFAOYSA-N 279002 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methylthiazol-5-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 32::US10512632, Example 32::US10766893, Example S32::US10806718, Example 32::US11026923, Example 32::US11491140, Example 32::US11634416, Example 32 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4.60 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279002&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273331 378160591 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272702 CCOc1ncccc1-c1cc(NCc2nnc(C)s2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H25N7OS/c1-6-29-21-15(8-7-9-22-21)16-10-17(23-11-18-26-25-14(5)30-18)20-19(24-16)13(4)27-28(20)12(2)3/h7-10,12H,6,11H2,1-5H3,(H,23,24) XQUFGMNXDPCXMM-UHFFFAOYSA-N 279003 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methyl-1,3,4-thiadiazol-2-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 33::US10512632, Example 33::US10766893, Example S33::US10806718, Example 33::US11026923, Example 33::US11491140, Example 33::US11634416, Example 33 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.60 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279003 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279003&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273332 378160592 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272705 CCOc1ncccc1-c1cc(NCc2csc(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N5OS/c1-6-29-23-18(8-7-9-24-23)19-11-20(25-12-17-10-15(4)30-13-17)22-21(26-19)16(5)27-28(22)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,25,26) VNCLCBKVWWHCAF-UHFFFAOYSA-N 279004 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methyl-3-thienyl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 34::US10512632, Example 34::US10766893, Example S34::US10806718, Example 34::US11026923, Example 34::US11491140, Example 34::US11634416, Example 34 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.10 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279004 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279004&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273333 378160593 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272708 CCOc1ncccc1-c1cc(NCc2cc(C)cs2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N5OS/c1-6-29-23-18(8-7-9-24-23)19-11-20(25-12-17-10-15(4)13-30-17)22-21(26-19)16(5)27-28(22)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,25,26) DHODKXCCORNYHA-UHFFFAOYSA-N 279005 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(4-methyl-2-thienyl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 35::US10512632, Example 35::US10766893, Example S35::US10806718, Example 35::US11026923, Example 35::US11491140, Example 35::US11634416, Example 35 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 7.30 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279005 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279005&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273334 378160594 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272711 CCOc1ncccc1-c1cc(NCc2ccc(C)s2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N5OS/c1-6-29-23-18(8-7-11-24-23)19-12-20(25-13-17-10-9-15(4)30-17)22-21(26-19)16(5)27-28(22)14(2)3/h7-12,14H,6,13H2,1-5H3,(H,25,26) MXNGXYQZCMFPJD-UHFFFAOYSA-N 279006 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methyl-2-thienyl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 36::US10512632, Example 36::US10766893, Example S36::US10806718, Example 36::US11026923, Example 36::US11491140, Example 36::US11634416, Example 36 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 24.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279006&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273337 378160595 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272714 CCOc1ncccc1-c1cc(NCc2coc(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6O2/c1-6-29-22-17(8-7-9-23-22)18-10-19(24-11-16-12-30-15(5)25-16)21-20(26-18)14(4)27-28(21)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,24,26) VZTGUNQMZSOPTA-UHFFFAOYSA-N 279007 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methyloxazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 37::US10512632, Example 37::US10766893, Example S37::US10806718, Example 37::US11026923, Example 37::US11491140, Example 37::US11634416, Example 37 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 5.90 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279007 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279007&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273335 378160596 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272717 CCOc1ncccc1-c1cc(NCc2ncc(C)o2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6O2/c1-6-29-22-16(8-7-9-23-22)17-10-18(24-12-19-25-11-14(4)30-19)21-20(26-17)15(5)27-28(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,24,26) IGMSFVIKHQRGSP-UHFFFAOYSA-N 279008 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methyloxazol-2-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 38::US10512632, Example 38::US10766893, Example S38::US10806718, Example 38::US11026923, Example 38::US11491140, Example 38::US11634416, Example 38 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.10 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279008 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279008&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273338 378160597 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272720 CCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H25N7O/c1-5-29-21-16(7-6-9-22-21)17-11-18(23-12-15-8-10-24-26-15)20-19(25-17)14(4)27-28(20)13(2)3/h6-11,13H,5,12H2,1-4H3,(H,23,25)(H,24,26) UOWVOVPKNPTQQH-UHFFFAOYSA-N 279009 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 39::US10512632, Example 39::US10766893, Example S39::US10806718, Example 39::US11026923, Example 39::US11491140, Example 39::US11634416, Example 39 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.10 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279009 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279009&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273340 378160598 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272723 CCOc1ncccc1-c1cc(NCc2c[nH]cn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H25N7O/c1-5-29-21-16(7-6-8-23-21)17-9-18(24-11-15-10-22-12-25-15)20-19(26-17)14(4)27-28(20)13(2)3/h6-10,12-13H,5,11H2,1-4H3,(H,22,25)(H,24,26) IQIUSKXHLPBBOV-UHFFFAOYSA-N 279010 5-(2-ethoxy-3-pyridyl)-N-(1H-imidazol-4-ylmethyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 40::US10512632, Example 40::US10766893, Example S40::US10806718, Example 40::US11026923, Example 40::US11491140, Example 40::US11634416, Example 40 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 14.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279010 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279010&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273339 378160599 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272726 CCOc1ncccc1-c1cc(NCc2ccccc2)c2n(ncc2n1)C(C)C InChI=1S/C23H25N5O/c1-4-29-23-18(11-8-12-24-23)19-13-20(25-14-17-9-6-5-7-10-17)22-21(27-19)15-26-28(22)16(2)3/h5-13,15-16H,4,14H2,1-3H3,(H,25,27) CAHURFTWFHHOPU-UHFFFAOYSA-N 279011 N-benzyl-5-(2-ethoxy-3-pyridyl)-1-isopropyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 41::US10512632, Example 41::US10618913, Example S41::US10766893, Example S41::US10806718, Example 41::US11026923, Example 41::US11634416, Example 41 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 500 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279011 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279011&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273336 378160600 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272729 CCOc1ncccc1-c1cc(NCc2cc(C)no2)c2n(ncc2n1)C(C)C InChI=1S/C21H24N6O2/c1-5-28-21-16(7-6-8-22-21)17-10-18(23-11-15-9-14(4)26-29-15)20-19(25-17)12-24-27(20)13(2)3/h6-10,12-13H,5,11H2,1-4H3,(H,23,25) ZGFGKVRUAVJQMR-UHFFFAOYSA-N 279012 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(3-methylisoxazol-5-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 42::US10512632, Example 42::US10766893, Example S42::US10806718, Example 42::US11026923, Example 42::US11634416, Example 42 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 82.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279012&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273341 378160601 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272732 CCOc1ncccc1-c1cc(NCc2noc(C)n2)c2n(ncc2n1)C(C)C InChI=1S/C20H23N7O2/c1-5-28-20-14(7-6-8-21-20)15-9-16(22-11-18-24-13(4)29-26-18)19-17(25-15)10-23-27(19)12(2)3/h6-10,12H,5,11H2,1-4H3,(H,22,25) SDTZIRBETDMBLS-UHFFFAOYSA-N 279013 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 43::US10512632, Example 43::US10766893, Example S43::US10806718, Example 43::US11026923, Example 43::US11634416, Example 43 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 30.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279013&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273344 378160602 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272735 CCOc1ncccc1-c1cc(NCc2cc(C)n(C)n2)c2n(ncc2n1)C(C)C InChI=1S/C22H27N7O/c1-6-30-22-17(8-7-9-23-22)18-11-19(24-12-16-10-15(4)28(5)27-16)21-20(26-18)13-25-29(21)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,24,26) RWTZKAWRGHZQKR-UHFFFAOYSA-N 279014 N-[(1,5-dimethylpyrazol-3-yl)methyl]-5-(2-ethoxy-3-pyridyl)-1-isopropyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 44::US10512632, Example 44::US10766893, Example S44::US10806718, Example 44::US11026923, Example 44::US11634416, Example 44 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 19.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279014 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279014&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273342 378160603 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272738 CCOc1ncccc1-c1cc(NCc2ccc(=O)n(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(8-7-11-25-24)19-12-20(26-13-17-9-10-21(31)29(5)14-17)23-22(27-19)16(4)28-30(23)15(2)3/h7-12,14-15H,6,13H2,1-5H3,(H,26,27) IFSZKCSGKSFXTM-UHFFFAOYSA-N 279015 3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4-yl)methyl)amino)-1H-pyrazolo[4,3-b]pyridin-5-yl)-1-methylpyridin-2(1H)-one::US10034861, Example 45::US10512632, Example 45::US10806718, Example 45::US11026923, Example 45::US11491140, Example 45::US11634416, Example 45 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.00 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279015 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279015&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273343 378160604 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272741 CCOc1ncccc1-c1cc(NCc2c[nH]c(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H27N7O/c1-6-30-22-17(8-7-9-23-22)18-10-19(25-12-16-11-24-15(5)26-16)21-20(27-18)14(4)28-29(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,24,26)(H,25,27) OESORFJHOJQXKR-UHFFFAOYSA-N 279016 5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((2-methyl-1H-imidazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 46::US10512632, Example 46::US10766893, Example S46::US10806718, Example 46::US11026923, Example 46::US11491140, Example 46::US11634416, Example 46 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 5.00 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279016&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273345 378160605 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272744 CCOc1ncccc1-c1cc(NCc2cc(C)[nH]n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H27N7O/c1-6-30-22-17(8-7-9-23-22)18-11-19(24-12-16-10-14(4)26-27-16)21-20(25-18)15(5)28-29(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,24,25)(H,26,27) BKIZQOUWXXJIIE-UHFFFAOYSA-N 279017 5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((5-methyl-1H-pyrazol-3-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 47::US10512632, Example 47::US10766893, Example S54::US10806718, Example 47::US11026923, Example 47::US11491140, Example 47::US11634416, Example 47 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.60 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279017&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273346 378160606 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272747 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(CC)nc(C)c2n1 InChI=1S/C21H25N7O/c1-5-28-20-18(23-11-15-12-24-27(4)13-15)10-17(25-19(20)14(3)26-28)16-8-7-9-22-21(16)29-6-2/h7-10,12-13H,5-6,11H2,1-4H3,(H,23,25) ALQSQGPOANFHOP-UHFFFAOYSA-N 279018 5-(2-ethoxypyridin-3-yl)-1-ethyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 48::US10512632, Example 48::US10618913, Example S48::US10766893, Example S48::US10806718, Example 48::US11026923, Example 48::US11491140, Example 48::US11634416, Example 48 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 38.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279018&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273347 378160607 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272750 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1cccn(C)c1=O InChI=1S/C21H25N7O/c1-13(2)28-20-18(22-10-15-11-23-27(5)12-15)9-17(24-19(20)14(3)25-28)16-7-6-8-26(4)21(16)29/h6-9,11-13H,10H2,1-5H3,(H,22,24) MRQVRXHGMURIIP-UHFFFAOYSA-N 279019 3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4-yl)methyl)amino)-1H-pyrazolo[4,3-b]pyridin-5-yl)-1-methylpyridin-2(1H)-one::US10034861, Example 49::US10512632, Example 49::US10766893, Example S49::US10806718, Example 49::US11026923, Example 49::US11491140, Example 49::US11634416, Example 49 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 170 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279019 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279019&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273348 378160608 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272753 CCOc1ncccc1-c1cc(NCc2nc(C)co2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6O2/c1-6-29-22-16(8-7-9-23-22)17-10-18(24-11-19-25-14(4)12-30-19)21-20(26-17)15(5)27-28(21)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,24,26) LWOWQQZYEXAZTD-UHFFFAOYSA-N 279020 5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((4-methyloxazol-2-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine 2,2,2-trifluoroacetate::US10034861, Example 50::US10512632, Example 50::US10766893, Example S50::US10806718, Example 50::US11026923, Example 50::US11491140, Example 50::US11634416, Example 50 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 9.00 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279020 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279020&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273350 378160609 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272756 CCOc1ncccc1-c1cc(NCc2cn(C)c(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H29N7O/c1-7-31-23-18(9-8-10-24-23)19-11-20(25-12-17-13-29(6)16(5)26-17)22-21(27-19)15(4)28-30(22)14(2)3/h8-11,13-14H,7,12H2,1-6H3,(H,25,27) RIBLUNUCLUPFGL-UHFFFAOYSA-N 279021 N-((1,2-dimethyl-1H-imidazol-4-yl)methyl)-5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-1H-pyrazolo[4,3-b]pyridin-7-amine 2,2,2-trifluoroacetate::US10034861, Example 51::US10512632, Example 51::US10766893, Example S51::US10806718, Example 51::US11026923, Example 51::US11491140, Example 51::US11634416, Example 51 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 53.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279021 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279021&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273354 378160610 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272759 CCOc1ncccc1-c1cc(NCC(=N)\N=C(\C)O)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H27N7O2/c1-6-30-21-15(8-7-9-23-21)16-10-17(24-11-18(22)25-14(5)29)20-19(26-16)13(4)27-28(20)12(2)3/h7-10,12H,6,11H2,1-5H3,(H,24,26)(H2,22,25,29) QXJFQZUUSSXBPR-UHFFFAOYSA-N 601481 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5- methyl-1,2,4-oxadiazol-3-yl)methyl]pyrazolo[4,3- b]pyridin-7-amine::US11634416, Example 52 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.90 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601481 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601481&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 155647870 482092570 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272762 CCOc1ncccc1-c1cc(NCc2ncon2)c2n(nc(C)c2n1)C(C)C InChI=1S/C20H23N7O2/c1-5-28-20-14(7-6-8-21-20)15-9-16(22-10-17-23-11-29-26-17)19-18(24-15)13(4)25-27(19)12(2)3/h6-9,11-12H,5,10H2,1-4H3,(H,22,24) HUAHNRHWFFYRAT-UHFFFAOYSA-N 279023 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1,2,4-oxadiazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 53::US10512632, Example 53::US10766893, Example S53::US10806718, Example 53::US11026923, Example 53::US11491140, Example 53::US11634416, Example 53 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 9.30 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279023&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273357 378160612 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272765 CCOc1ncccc1-c1cc(NCc2cc(C)n(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H29N7O/c1-7-31-23-18(9-8-10-24-23)19-12-20(25-13-17-11-15(4)29(6)28-17)22-21(26-19)16(5)27-30(22)14(2)3/h8-12,14H,7,13H2,1-6H3,(H,25,26) LOSBPLVFUGTAOA-UHFFFAOYSA-N 279024 N-[(1,5-dimethylpyrazol-3-yl)methyl]-5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 54::US10512632, Example 54::US10806718, Example 54::US11026923, Example 54::US11491140, Example 54::US11634416, Example 54 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.390 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279024 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279024&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273352 378160613 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272768 CCOc1ncccc1-c1cc(NCc2n[nH]c(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H26N8O/c1-6-30-21-15(8-7-9-22-21)16-10-17(23-11-18-24-14(5)26-27-18)20-19(25-16)13(4)28-29(20)12(2)3/h7-10,12H,6,11H2,1-5H3,(H,23,25)(H,24,26,27) QVFBWQCMGPADBC-UHFFFAOYSA-N 279025 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-methyl-1H-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 55::US10512632, Example 55::US10766893, Example S55::US10806718, Example 55::US11026923, Example 55::US11491140, Example 55::US11634416, Example 55 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 3.40 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279025&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273353 378160614 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272771 CCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(ncc2n1)C(C)C InChI=1S/C20H24N8O/c1-5-29-20-14(7-6-8-21-20)15-9-16(22-11-18-23-12-27(4)26-18)19-17(25-15)10-24-28(19)13(2)3/h6-10,12-13H,5,11H2,1-4H3,(H,22,25) LBAWYUCYPDZBSF-UHFFFAOYSA-N 279026 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 56::US10512632, Example 56::US10766893, Example S56::US10806718, Example 56::US11026923, Example 56::US11491140, Example 56::US11634416, Example 56 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 16.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279026&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273358 378160615 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272774 CCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(ncc2n1)C(C)C InChI=1S/C20H23N7O/c1-4-28-20-15(6-5-8-21-20)16-10-17(22-11-14-7-9-23-26-14)19-18(25-16)12-24-27(19)13(2)3/h5-10,12-13H,4,11H2,1-3H3,(H,22,25)(H,23,26) RZEYZCLEVMBHDS-UHFFFAOYSA-N 279027 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 57::US10512632, Example 57::US10766893, Example S57::US10806718, Example 57::US11026923, Example 57::US11491140, Example 57::US11634416, Example 57 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 98.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279027&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273355 378160616 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272777 CCOc1ncccc1-c1cc(NCc2cn(C)cn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H27N7O/c1-6-30-22-17(8-7-9-23-22)18-10-19(24-11-16-12-28(5)13-25-16)21-20(26-18)15(4)27-29(21)14(2)3/h7-10,12-14H,6,11H2,1-5H3,(H,24,26) LRTCNZDFQQIFPH-UHFFFAOYSA-N 279028 5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((1-methyl-1H-imidazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine 2,2,2-trifluoroacetate::US10034861, Example 58::US10512632, Example 58::US10766893, Example S58::US10806718, Example 58::US11026923, Example 58::US11491140, Example 58::US11634416, Example 58 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.10 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279028&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273360 378160617 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272780 CCOc1ncccc1-c1cc(NCc2nnco2)c2n(nc(C)c2n1)C(C)C InChI=1S/C20H23N7O2/c1-5-28-20-14(7-6-8-21-20)15-9-16(22-10-17-25-23-11-29-17)19-18(24-15)13(4)26-27(19)12(2)3/h6-9,11-12H,5,10H2,1-4H3,(H,22,24) AHFKEZBAZQXEDY-UHFFFAOYSA-N 279029 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1,3,4-oxadiazol-2-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 59::US10512632, Example 59::US10766893, Example S59::US10806718, Example 59::US11026923, Example 59::US11491140, Example 59::US11634416, Example 59 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 55.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279029&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273356 378160618 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272783 CCOc1ncccc1-c1cc(NCc2ccn(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H27N7O/c1-6-30-22-17(8-7-10-23-22)18-12-19(24-13-16-9-11-28(5)27-16)21-20(25-18)15(4)26-29(21)14(2)3/h7-12,14H,6,13H2,1-5H3,(H,24,25) FXMRNOZDEMMBMY-UHFFFAOYSA-N 279030 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(1-methylpyrazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 60::US10512632, Example 60::US10766893, Example S60::US10806718, Example 60::US11491140, Example 60::US11634416, Example 60 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 6.50 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279030&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273369 378160619 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272786 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1cn(C)nc1C InChI=1S/C20H26N8/c1-12(2)28-20-18(21-8-15-9-22-26(5)10-15)7-17(23-19(20)14(4)25-28)16-11-27(6)24-13(16)3/h7,9-12H,8H2,1-6H3,(H,21,23) SZOKENQFAYLAJE-UHFFFAOYSA-N 279031 5-(1,3-dimethylpyrazol-4-yl)-1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 61::US10512632, Example 61::US10618913, Example S61::US10766893, Example S61::US10806718, Example 61::US11491140, Example 61::US11634416, Example 61 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 550 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279031&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273370 378160620 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272789 COc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H25N7O/c1-13(2)28-20-18(23-10-15-11-24-27(4)12-15)9-17(25-19(20)14(3)26-28)16-7-6-8-22-21(16)29-5/h6-9,11-13H,10H2,1-5H3,(H,23,25) NDQZTZXQHDYXCS-UHFFFAOYSA-N 279032 1-isopropyl-5-(2-methoxy-3-pyridyl)-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 62::US10512632, Example 62::US10766893, Example S62::US10806718, Example 62::US11491140, Example 62::US11634416, Example 62 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 16.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279032&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273362 378160621 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272792 COc1ccccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H26N6O/c1-14(2)28-22-19(23-11-16-12-24-27(4)13-16)10-18(25-21(22)15(3)26-28)17-8-6-7-9-20(17)29-5/h6-10,12-14H,11H2,1-5H3,(H,23,25) KTDTYSKLFCIVHF-UHFFFAOYSA-N 279033 1-isopropyl-5-(2-methoxyphenyl)-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 63::US10512632, Example 63::US10766893, Example S63::US10806718, Example 63::US11491140, Example 63::US11634416, Example 63 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 64.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279033&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273359 378160622 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272795 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1ccccc1 InChI=1S/C21H24N6/c1-14(2)27-21-19(22-11-16-12-23-26(4)13-16)10-18(17-8-6-5-7-9-17)24-20(21)15(3)25-27/h5-10,12-14H,11H2,1-4H3,(H,22,24) JFQFIBIPASGZMG-UHFFFAOYSA-N 279034 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-phenyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 64::US10512632, Example 64::US10766893, Example S64::US10806718, Example 64::US11491140, Example 64::US11634416, Example 64 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 52.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279034&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273365 378160623 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272798 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1ccsc1C InChI=1S/C20H24N6S/c1-12(2)26-20-18(21-9-15-10-22-25(5)11-15)8-17(16-6-7-27-14(16)4)23-19(20)13(3)24-26/h6-8,10-12H,9H2,1-5H3,(H,21,23) OOGMCENLMFETDO-UHFFFAOYSA-N 279035 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-(2-methyl-3-thienyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 65::US10512632, Example 65::US10766893, Example S65::US10806718, Example 65::US11491140, Example 65::US11634416, Example 65 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 7.90 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279035&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273363 378160624 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272801 CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1cnn(C)c1C InChI=1S/C20H26N8/c1-12(2)28-20-18(21-8-15-9-22-26(5)11-15)7-17(24-19(20)13(3)25-28)16-10-23-27(6)14(16)4/h7,9-12H,8H2,1-6H3,(H,21,24) IOBLPVSVJNVETM-UHFFFAOYSA-N 279036 5-(1,5-dimethylpyrazol-4-yl)-1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 66::US10512632, Example 66::US10766893, Example S66::US10806718, Example 66::US11491140, Example 66::US11634416, Example 66 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 210 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279036&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273361 378160625 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272804 CCOc1ncccc1-c1cc(NCc2ccn(C)n2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C23H29N7O/c1-6-15(3)30-22-20(25-14-17-10-12-29(5)28-17)13-19(26-21(22)16(4)27-30)18-9-8-11-24-23(18)31-7-2/h8-13,15H,6-7,14H2,1-5H3,(H,25,26) GUZUXYPWYDLGJF-UHFFFAOYSA-N 279037 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]-N-[(1-methylpyrazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 67::US10512632, Example 67::US10618913, Example S67::US10766893, Example S67::US10806718, Example 67::US11634416, Example 67 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 9.60 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279037 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279037&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273371 378160626 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1266934 Fc1ccc(cc1)-c1ncc2n1cc(CN1CC(C1)Oc1ccncc1)[nH]c2=O InChI=1S/C21H18FN5O2/c22-15-3-1-14(2-4-15)20-24-9-19-21(28)25-16(11-27(19)20)10-26-12-18(13-26)29-17-5-7-23-8-6-17/h1-9,11,18H,10,12-13H2,(H,25,28) OPPJESMUQLKXLM-UHFFFAOYSA-N 559569 US11370795, Compound (P1)::US11608342, Compound (P1) Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 45090 US Patent 10.7270/Q2NP28BZ US11608342 Svenstrup, N; Wen, K; Wang, Y H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=559569 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=559569&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 71550147 471700197 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1266936 O=c1[nH]c(CN2CC(C2)Oc2ccncc2)cn2c(ncc12)C1CCOCC1 InChI=1S/C20H23N5O3/c26-20-18-9-22-19(14-3-7-27-8-4-14)25(18)11-15(23-20)10-24-12-17(13-24)28-16-1-5-21-6-2-16/h1-2,5-6,9,11,14,17H,3-4,7-8,10,12-13H2,(H,23,26) OOGGVHCCYMTPOH-UHFFFAOYSA-N 597862 US11608342, Compound (P2) Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 5283 US Patent 10.7270/Q2NP28BZ US11608342 Svenstrup, N; Wen, K; Wang, Y H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=597862 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=597862&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 71550143 481722236 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1266938 C[C@@H]1CN(Cc2ncccn2)C[C@H]1c1cn2c(ncc2c(=O)[nH]1)C1CCOCC1 426313 US10513524, Compound (P3::US11608342, Compound (P3) Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 3000 US Patent 10.7270/Q2NP28BZ US11608342 Svenstrup, N; Wen, K; Wang, Y H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=426313 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=426313&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 124220601 434320652 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1266940 Fc1ccc(COC2CN(Cc3nn4c(ncc4c(=O)[nH]3)C3CCOCC3)C2)cc1 InChI=1S/C21H24FN5O3/c22-16-3-1-14(2-4-16)13-30-17-10-26(11-17)12-19-24-21(28)18-9-23-20(27(18)25-19)15-5-7-29-8-6-15/h1-4,9,15,17H,5-8,10-13H2,(H,24,25,28) QEJJXMNBAFWGJK-UHFFFAOYSA-N 247206 US10513524, Compound (P4)::US11608342, Compound (P4)::US9434733, 2-[[3-[(4-fluorophenyl)methoxy]azetidin-1-yl]methyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[[3-[(4-fluorophenyl)methoxy]azetidin-1-yl]methyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1009 US Patent 10.7270/Q2NP28BZ US11608342 Svenstrup, N; Wen, K; Wang, Y H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247206 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247206&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 78147589 346541753 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1266942 C[C@@H]1CN(Cc2ncccn2)C[C@H]1c1nc2n(ncc2c(=O)[nH]1)C1CCOCC1 InChI=1S/C20H25N7O2/c1-13-10-26(12-17-21-5-2-6-22-17)11-16(13)18-24-19-15(20(28)25-18)9-23-27(19)14-3-7-29-8-4-14/h2,5-6,9,13-14,16H,3-4,7-8,10-12H2,1H3,(H,24,25,28)/t13-,16-/m1/s1 IWXUVYOOUMLUTQ-CZUORRHYSA-N 50397838 CHEMBL2179105::PF-04447943::US10513524, Reference compound disclosed in WO2008/139293::US11608342, Reference compound disclosed in WO2008/139293 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2500 US Patent 10.7270/Q2NP28BZ US11608342 Svenstrup, N; Wen, K; Wang, Y H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397838&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 7RG 25115162 163346862 CHEMBL2179105 ZINC68199983 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272807 CCCOc1ncccc1-c1cc(NCc2nnn(C)n2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C22H29N9O/c1-6-11-32-22-16(9-8-10-23-22)17-12-18(24-13-19-26-29-30(5)28-19)21-20(25-17)15(4)27-31(21)14(3)7-2/h8-10,12,14H,6-7,11,13H2,1-5H3,(H,24,25) DGDYHVXCROBNNK-UHFFFAOYSA-N 279038 3-methyl-1-[1-methylpropyl]-N-[(2-methyltetrazol-5-yl)methyl]-5-(2-propoxy-3-pyridyl)pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 68::US10512632, Example 68::US10766893, Example S68::US10806718, Example 68::US11634416, Example 68 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.790 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279038 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279038&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273364 378160627 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272810 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(ncc2n1)C(C)CC InChI=1S/C22H27N7O/c1-5-15(3)29-21-19(24-11-16-12-25-28(4)14-16)10-18(27-20(21)13-26-29)17-8-7-9-23-22(17)30-6-2/h7-10,12-15H,5-6,11H2,1-4H3,(H,24,27) PNGBBNJWUZFNIY-UHFFFAOYSA-N 279039 5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine, enantiomer 1::US10034861, Example 69::US10034861, Example 70::US10512632, Example 70::US10618913, Example S69::US10766893, Example S70::US10806718, Example 70::US11634416, Example 70 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 14.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279039&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273366 378160628 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272813 CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(ncc2n1)C(C)CC InChI=1S/C22H27N7O/c1-5-15(3)29-21-19(24-11-16-12-25-28(4)14-16)10-18(27-20(21)13-26-29)17-8-7-9-23-22(17)30-6-2/h7-10,12-15H,5-6,11H2,1-4H3,(H,24,27) PNGBBNJWUZFNIY-UHFFFAOYSA-N 279039 5-(2-ethoxy-3-pyridyl)-1-[1-methylpropyl]-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine, enantiomer 1::US10034861, Example 69::US10034861, Example 70::US10512632, Example 70::US10618913, Example S69::US10766893, Example S70::US10806718, Example 70::US11634416, Example 70 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 140 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279039&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273366 378160628 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272816 CCOc1ncccc1-c1cc(NCc2scnc2C)c2n(ncc2n1)C(C)C InChI=1S/C21H24N6OS/c1-5-28-21-15(7-6-8-22-21)16-9-17(23-11-19-14(4)24-12-29-19)20-18(26-16)10-25-27(20)13(2)3/h6-10,12-13H,5,11H2,1-4H3,(H,23,26) CKGZFAMXPLRINR-UHFFFAOYSA-N 424981 US10512632, Example 71::US10766893, Example S71::US10806718, Example 71::US11026923, Example 71::US11491140, Example 71::US11634416, Example 71 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 170 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=424981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=424981&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 138536011 434150492 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272819 CCOc1ncccc1-c1cc(OCc2cnc(C)o2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H25N5O3/c1-6-28-22-17(8-7-9-23-22)18-10-19(29-12-16-11-24-15(5)30-16)21-20(25-18)14(4)26-27(21)13(2)3/h7-11,13H,6,12H2,1-5H3 PFDYAXRVKURLCH-UHFFFAOYSA-N 279042 5-[[5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-yl]oxymethyl]-2-methyl-oxazole::US10034861, Example 72::US10512632, Example 72::US10766893, Example S72::US10806718, Example 72::US11491140, Example 72::US11634416, Example 72 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 14.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279042&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273372 378160630 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272822 CCOc1ncccc1-c1cc(NCc2ccncn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H25N7O/c1-5-30-22-17(7-6-9-24-22)18-11-19(25-12-16-8-10-23-13-26-16)21-20(27-18)15(4)28-29(21)14(2)3/h6-11,13-14H,5,12H2,1-4H3,(H,25,27) UIVWJGFOIVSSOG-UHFFFAOYSA-N 279043 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(pyrimidin-4-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 73::US10512632, Example 73::US10766893, Example S73::US10806718, Example 73::US11491140, Example 73::US11634416, Example 73 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 81.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279043&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273379 378160631 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272825 CCOc1ncccc1-c1cc(NCc2ncccn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H25N7O/c1-5-30-22-16(8-6-9-25-22)17-12-18(26-13-19-23-10-7-11-24-19)21-20(27-17)15(4)28-29(21)14(2)3/h6-12,14H,5,13H2,1-4H3,(H,26,27) DFFZMDINLLNNPV-UHFFFAOYSA-N 279044 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(pyrimidin-2-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 74::US10512632, Example 74::US10766893, Example S74::US10806718, Example 74::US11491140, Example 74::US11634416, Example 74 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.10 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279044&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273368 378160632 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272828 CCOc1ncccc1-c1cc(NCc2nccc(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O/c1-6-31-23-17(8-7-10-25-23)18-12-19(26-13-20-24-11-9-15(4)27-20)22-21(28-18)16(5)29-30(22)14(2)3/h7-12,14H,6,13H2,1-5H3,(H,26,28) ZCARSOPJYGJCRQ-UHFFFAOYSA-N 279045 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(4-methylpyrimidin-2-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 75::US10512632, Example 75::US10806718, Example 75::US11026923, Example 75::US11491140, Example 75::US11634416, Example 75 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 9.90 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279045&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273374 378160633 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272831 CCOc1ncccc1-c1cc(NCc2cnccn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H25N7O/c1-5-30-22-17(7-6-8-25-22)18-11-19(26-13-16-12-23-9-10-24-16)21-20(27-18)15(4)28-29(21)14(2)3/h6-12,14H,5,13H2,1-4H3,(H,26,27) DTEHKURDWHCADV-UHFFFAOYSA-N 279046 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(pyrazin-2-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 76::US10512632, Example 76::US10766893, Example S76::US10806718, Example 76::US11026923, Example 76::US11491140, Example 76::US11634416, Example 76 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 23.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279046&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273373 378160634 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272834 CCOc1ncccc1-c1cc(NCc2cccnc2C(F)(F)F)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H25F3N6O/c1-5-34-23-17(9-7-11-29-23)18-12-19(21-20(31-18)15(4)32-33(21)14(2)3)30-13-16-8-6-10-28-22(16)24(25,26)27/h6-12,14H,5,13H2,1-4H3,(H,30,31) TZBBGNNWRKPAEH-UHFFFAOYSA-N 279047 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[2-(trifluoromethyl)-3-pyridyl]methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 77::US10512632, Example 77::US10766893, Example S77::US10806718, Example 77::US11026923, Example 77::US11491140, Example 77::US11634416, Example 77 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 21.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279047&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273376 378160635 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272837 CCOc1ncccc1-c1cc(NCc2ccn(C)c(=O)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(8-7-10-25-24)19-13-20(26-14-17-9-11-29(5)21(31)12-17)23-22(27-19)16(4)28-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,26,27) IBAWDCALOOJODQ-UHFFFAOYSA-N 279048 4-[[[5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-yl]amino]methyl]-1-methyl-pyridin-2-one::US10034861, Example 78::US10512632, Example 78::US10766893, Example S78::US10806718, Example 78::US11026923, Example 78::US11491140, Example 78::US11634416, Example 78 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 27.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279048&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273377 378160636 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272840 CCNc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H28N8/c1-6-23-22-17(8-7-9-24-22)18-10-19(25-11-16-12-26-29(5)13-16)21-20(27-18)15(4)28-30(21)14(2)3/h7-10,12-14H,6,11H2,1-5H3,(H,23,24)(H,25,27) ZEUKRJZWWLBXIK-UHFFFAOYSA-N 279049 5-(2-(ethylamino)pyridin-3-yl)-1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 79::US10512632, Example 79::US10766893, Example S79::US10806718, Example 79::US11026923, Example 79::US11491140, Example 79::US11634416, Example 79 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 230 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279049&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273375 378160637 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272843 CCOc1ncccc1-c1cc(NCc2cc(OC)ccn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-19(8-7-10-26-24)20-13-21(27-14-17-12-18(31-5)9-11-25-17)23-22(28-20)16(4)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) BVKDBZHCRMPMSA-UHFFFAOYSA-N 279050 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(4-methoxy-2-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 81::US10512632, Example 81::US10766893, Example S81::US10806718, Example 81::US11026923, Example 81::US11491140, Example 81::US11634416, Example 81 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.000 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279050&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273378 378160638 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272846 CCOc1ncccc1-c1cc(NCc2cncc(OC)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O2/c1-6-32-23-17(8-7-9-25-23)18-10-19(26-12-16-11-24-13-20(27-16)31-5)22-21(28-18)15(4)29-30(22)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,26,28) OSHMEGNKNUJDSU-UHFFFAOYSA-N 279051 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(6-methoxypyrazin-2-yl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 82::US10512632, Example 82::US10766893, Example S82::US10806718, Example 82::US11026923, Example 82::US11491140, Example 82::US11634416, Example 82 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 16.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279051&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273380 378160639 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272849 CCOc1ncccc1-c1cc(NCc2ncc(F)cn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C22H24FN7O/c1-5-31-22-16(7-6-8-24-22)17-9-18(25-12-19-26-10-15(23)11-27-19)21-20(28-17)14(4)29-30(21)13(2)3/h6-11,13H,5,12H2,1-4H3,(H,25,28) ZIOQYWFVMVDZRK-UHFFFAOYSA-N 279052 5-(2-ethoxy-3-pyridyl)-N-[(5-fluoropyrimidin-2-yl)methyl]-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 83::US10512632, Example 83::US10766893, Example S83::US10806718, Example 83::US11026923, Example 83::US11491140, Example 83::US11634416, Example 83 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 17.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279052&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273381 378160640 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272852 CCOc1ncccc1-c1cc(NCc2cccnc2C)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O/c1-6-31-24-19(10-8-12-26-24)20-13-21(27-14-18-9-7-11-25-16(18)4)23-22(28-20)17(5)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) JOFWPJKNNJOGJF-UHFFFAOYSA-N 279053 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methyl-3-pyridyl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 84::US10512632, Example 84::US10766893, Example S84::US10806718, Example 84::US11026923, Example 84::US11491140, Example 84::US11634416, Example 84 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 19.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279053&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273382 378160641 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272855 CCOc1ncccc1-c1cc(NCc2cccnc2F)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H25FN6O/c1-5-31-23-17(9-7-11-26-23)18-12-19(27-13-16-8-6-10-25-22(16)24)21-20(28-18)15(4)29-30(21)14(2)3/h6-12,14H,5,13H2,1-4H3,(H,27,28) JJLMBZVLDAMDGO-UHFFFAOYSA-N 279054 5-(2-ethoxy-3-pyridyl)-N-[(2-fluoro-3-pyridyl)methyl]-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 85::US10512632, Example 85::US10766893, Example S85::US10806718, Example 85::US11026923, Example 85::US11491140, Example 85::US11634416, Example 85 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.40 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279054&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273384 378160642 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272858 CCOc1ncccc1-c1cc(NCc2cccnc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(10-8-12-26-24)19-13-20(27-14-17-9-7-11-25-23(17)31-5)22-21(28-19)16(4)29-30(22)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) LOZUTDKVJLMDTB-UHFFFAOYSA-N 279055 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 172::US10034861, Example 180::US10034861, Example 181::US10034861, Example 182::US10034861, Example 86::US10512632, Example 86::US10766893, Example S86::US10806718, Example 182::US11026923, Example 182::US11491140, Example 86::US11634416, Example 86 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 20.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279055&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273386 378160643 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272861 CCOc1ncccc1-c1cc(NCc2ccc(C)nc2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O/c1-6-31-24-19(8-7-11-25-24)20-12-21(27-14-18-10-9-16(4)26-13-18)23-22(28-20)17(5)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) VEZPCNBBBMUATR-UHFFFAOYSA-N 279056 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(6-methyl-3-pyridyl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 87::US10512632, Example 87::US10766893, Example S87::US10806718, Example 87::US11026923, Example 87::US11491140, Example 87::US11634416, Example 87 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 6.30 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279056 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279056&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273383 378160644 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272864 CCOc1ncccc1-c1cc(NCc2ccccc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C25H29N5O2/c1-6-32-25-19(11-9-13-26-25)20-14-21(27-15-18-10-7-8-12-22(18)31-5)24-23(28-20)17(4)29-30(24)16(2)3/h7-14,16H,6,15H2,1-5H3,(H,27,28) IXQRCVAKBIMUJN-UHFFFAOYSA-N 279057 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxyphenyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 88::US10512632, Example 88::US10766893, Example S88::US10806718, Example 88::US11026923, Example 88::US11491140, Example 88::US11634416, Example 88 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 110 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279057&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273385 378160645 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272867 CCOc1ncccc1-c1cc(NCc2ccccc2F)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H26FN5O/c1-5-31-24-18(10-8-12-26-24)20-13-21(27-14-17-9-6-7-11-19(17)25)23-22(28-20)16(4)29-30(23)15(2)3/h6-13,15H,5,14H2,1-4H3,(H,27,28) PBVAXRZBSWSQNU-UHFFFAOYSA-N 279058 5-(2-ethoxy-3-pyridyl)-N-[(2-fluorophenyl)methyl]-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 89::US10512632, Example 89::US10766893, Example S89::US10806718, Example 89::US11026923, Example 89::US11491140, Example 89::US11634416, Example 89 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 61.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279058&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273388 378160646 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272870 CCOc1ncccc1-c1cc(NCc2ccccc2C(F)(F)F)c2n(nc(C)c2n1)C(C)C InChI=1S/C25H26F3N5O/c1-5-34-24-18(10-8-12-29-24)20-13-21(23-22(31-20)16(4)32-33(23)15(2)3)30-14-17-9-6-7-11-19(17)25(26,27)28/h6-13,15H,5,14H2,1-4H3,(H,30,31) XUHWSBHEGYQEDI-UHFFFAOYSA-N 279059 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[2-(trifluoromethyl)phenyl]methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 90::US10512632, Example 90::US10766893, Example S90::US10806718, Example 90::US11026923, Example 90::US11491140, Example 90::US11634416, Example 90 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 270 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279059&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273387 378160647 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272873 CCOc1ncccc1-c1cc(NCc2nccnc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O2/c1-6-32-22-16(8-7-9-25-22)17-12-18(27-13-19-23(31-5)26-11-10-24-19)21-20(28-17)15(4)29-30(21)14(2)3/h7-12,14H,6,13H2,1-5H3,(H,27,28) GJZNHSHBNVLOAO-UHFFFAOYSA-N 279060 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(3-methoxypyrazin-2-yl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 91::US10512632, Example 91::US10766893, Example S91::US10806718, Example 91::US11026923, Example 91::US11491140, Example 91::US11634416, Example 91 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 27.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279060&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273389 378160648 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272876 CCOc1ncccc1-c1cc(NCc2cnccc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(8-7-10-26-24)19-12-20(27-14-17-13-25-11-9-21(17)31-5)23-22(28-19)16(4)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) BHINMZMKXRIBEG-UHFFFAOYSA-N 279061 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(4-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 92::US10512632, Example 92::US10766893, Example S92::US10806718, Example 92::US11026923, Example 92::US11491140, Example 92::US11634416, Example 92 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 47.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279061&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273390 378160649 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272879 CCCOc1ncccc1-c1cc(NCc2nnn(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C21H27N9O/c1-6-10-31-21-15(8-7-9-22-21)16-11-17(23-12-18-25-28-29(5)27-18)20-19(24-16)14(4)26-30(20)13(2)3/h7-9,11,13H,6,10,12H2,1-5H3,(H,23,24) IEZRRRCALKIRBN-UHFFFAOYSA-N 279062 1-isopropyl-3-methyl-N-[(2-methyltetrazol-5-yl)methyl]-5-(2-propoxy-3-pyridyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 93::US10512632, Example 93::US10766893, Example S93::US10806718, Example 93::US11026923, Example 93::US11491140, Example 93::US11634416, Example 93 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4.30 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279062&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273393 378160650 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272882 CCCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H29N7O/c1-6-10-31-23-18(8-7-9-24-23)19-11-20(25-12-17-13-26-29(5)14-17)22-21(27-19)16(4)28-30(22)15(2)3/h7-9,11,13-15H,6,10,12H2,1-5H3,(H,25,27) JYRPZCKZXZYAOY-UHFFFAOYSA-N 279063 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-(2-propoxy-3-pyridyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 94::US10512632, Example 94::US10766893, Example S94::US10806718, Example 94::US11026923, Example 94::US11491140, Example 94::US11634416, Example 94 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.40 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279063&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273391 378160651 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272885 COc1ncccc1CNc1cc(nc2c(C)nn(C(C)C)c12)-c1cccnc1OC InChI=1S/C23H26N6O2/c1-14(2)29-21-19(26-13-16-8-6-10-24-22(16)30-4)12-18(27-20(21)15(3)28-29)17-9-7-11-25-23(17)31-5/h6-12,14H,13H2,1-5H3,(H,26,27) YPNDBZHHIYJRNN-UHFFFAOYSA-N 279064 1-isopropyl-5-(2-methoxy-3-pyridyl)-N-[(2-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 95::US10512632, Example 95::US10766893, Example S95::US10806718, Example 95::US11026923, Example 95::US11491140, Example 95::US11634416, Example 95 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 42.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279064 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279064&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273392 378160652 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272888 COc1ccc(CNc2cc(nc3c(C)nn(C(C)C)c23)-c2cccnc2OC)cn1 InChI=1S/C23H26N6O2/c1-14(2)29-22-19(25-12-16-8-9-20(30-4)26-13-16)11-18(27-21(22)15(3)28-29)17-7-6-10-24-23(17)31-5/h6-11,13-14H,12H2,1-5H3,(H,25,27) HUQJJAUBVULGLS-UHFFFAOYSA-N 279065 1-isopropyl-5-(2-methoxy-3-pyridyl)-N-[(6-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 96::US10512632, Example 96::US10766893, Example S96::US10806718, Example 96::US11026923, Example 96::US11491140, Example 96::US11634416, Example 96 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 18.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279065&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273394 378160653 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272891 CC(C)Oc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H29N7O/c1-14(2)30-22-20(25-11-17-12-26-29(6)13-17)10-19(27-21(22)16(5)28-30)18-8-7-9-24-23(18)31-15(3)4/h7-10,12-15H,11H2,1-6H3,(H,25,27) IWDHUHWZRSHWGD-UHFFFAOYSA-N 279066 5-(2-isopropoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 97::US10512632, Example 97::US10766893, Example S97::US10806718, Example 97::US11026923, Example 97::US11491140, Example 97::US11634416, Example 97 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.40 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279066&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273395 378160654 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272894 CCOc1ncccc1-c1cc(NCc2nc[nH]n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C20H24N8O/c1-5-29-20-14(7-6-8-21-20)15-9-16(22-10-17-23-11-24-26-17)19-18(25-15)13(4)27-28(19)12(2)3/h6-9,11-12H,5,10H2,1-4H3,(H,22,25)(H,23,24,26) ZUZXEJWHRNAFBA-UHFFFAOYSA-N 279067 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1H-1,2,4-triazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 98::US10512632, Example 98::US10766893, Example S98::US10806718, Example 98::US11491140, Example 98::US11634416, Example 98 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 7.20 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279067 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279067&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273396 378160655 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272897 CCOc1ncccc1-c1cc(NCc2nn[nH]n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C19H23N9O/c1-5-29-19-13(7-6-8-20-19)14-9-15(21-10-16-23-26-27-24-16)18-17(22-14)12(4)25-28(18)11(2)3/h6-9,11H,5,10H2,1-4H3,(H,21,22)(H,23,24,26,27) DBRGOFPEANLZGU-UHFFFAOYSA-N 279068 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(2H-tetrazol-5-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 99::US10512632, Example 99::US10766893, Example S99::US10806718, Example 99::US11026923, Example 99::US11491140, Example 99::US11634416, Example 99 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.730 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279068&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273399 378160656 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272900 CCOc1ncccc1-c1cc(NCc2ccccn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H26N6O/c1-5-30-23-18(10-8-12-25-23)19-13-20(26-14-17-9-6-7-11-24-17)22-21(27-19)16(4)28-29(22)15(2)3/h6-13,15H,5,14H2,1-4H3,(H,26,27) GWMDZOSIIBARTA-UHFFFAOYSA-N 279069 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(2-pyridylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 100::US10512632, Example 100::US10766893, Example S100::US10806718, Example 100::US11026923, Example 100::US11491140, Example 100::US11634416, Example 100 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 6.30 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279069&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273397 378160657 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272903 CCOc1ncccc1-c1cc(NCc2cccc(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O/c1-6-31-24-19(11-8-12-25-24)20-13-21(26-14-18-10-7-9-16(4)27-18)23-22(28-20)17(5)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,26,28) HBRGVUVPCCNRAT-UHFFFAOYSA-N 279070 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(6-methyl-2-pyridyl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 101::US10512632, Example 101::US10766893, Example S101::US10806718, Example 101::US11026923, Example 101::US11491140, Example 101::US11634416, Example 101 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 20.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279070&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273398 378160658 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272906 CCOc1ncccc1-c1cc(NCc2cccc(OC)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(10-8-12-25-24)19-13-20(26-14-17-9-7-11-21(27-17)31-5)23-22(28-19)16(4)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,26,28) DHUHVCYRBUZRAT-UHFFFAOYSA-N 279071 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(6-methoxy-2-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 102::US10512632, Example 102::US10766893, Example S102::US10806718, Example 102::US11026923, Example 102::US11491140, Example 102::US11634416, Example 102 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 8.00 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279071&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273400 378160659 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272909 CCOc1ncccc1-c1cc(NCc2ccnc(C)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O/c1-6-31-24-19(8-7-10-26-24)20-13-21(27-14-18-9-11-25-16(4)12-18)23-22(28-20)17(5)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) MPJXQIBFZBPJFH-UHFFFAOYSA-N 279072 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methyl-4-pyridyl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 103::US10512632, Example 103::US10766893, Example S103::US10806718, Example 103::US11026923, Example 103::US11491140, Example 103::US11634416, Example 103 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 5.40 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279072&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273402 378160660 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272912 CCOc1ncccc1-c1cc(NCc2ccnc(OC)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(8-7-10-26-24)19-13-20(27-14-17-9-11-25-21(12-17)31-5)23-22(28-19)16(4)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) SJJQCULDRYOYED-UHFFFAOYSA-N 279073 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(2-methoxy-4-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 104::US10512632, Example 104::US10766893, Example S104::US10806718, Example 104::US11026923, Example 104::US11491140, Example 104::US11634416, Example 104 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.20 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279073&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273401 378160661 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272915 CCOc1ncccc1-c1cc(NCc2ccnc(C)n2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O/c1-6-31-23-18(8-7-10-25-23)19-12-20(26-13-17-9-11-24-16(5)27-17)22-21(28-19)15(4)29-30(22)14(2)3/h7-12,14H,6,13H2,1-5H3,(H,26,28) OEGPBHHKEYGZCG-UHFFFAOYSA-N 279074 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methylpyrimidin-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 105::US10512632, Example 105::US10766893, Example S105::US10806718, Example 105::US11026923, Example 105::US11491140, Example 105::US11634416, Example 105 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 54.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279074&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273403 378160662 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272918 CCOc1ncccc1-c1cc(NCc2cncc(OC)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-19(8-7-9-26-24)20-11-21(27-13-17-10-18(31-5)14-25-12-17)23-22(28-20)16(4)29-30(23)15(2)3/h7-12,14-15H,6,13H2,1-5H3,(H,27,28) JCOKQWFPIMEUNS-UHFFFAOYSA-N 279075 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(5-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 106::US10512632, Example 106::US10766893, Example S106::US10806718, Example 106::US11026923, Example 106::US11491140, Example 106::US11634416, Example 106 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.10 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279075&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273404 378160663 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272921 CCOc1ncccc1-c1cc(NCc2cccc(n2)C(F)(F)F)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H25F3N6O/c1-5-34-23-17(9-7-11-28-23)18-12-19(22-21(31-18)15(4)32-33(22)14(2)3)29-13-16-8-6-10-20(30-16)24(25,26)27/h6-12,14H,5,13H2,1-4H3,(H,29,31) FVVVRFIRYVUVEI-UHFFFAOYSA-N 279076 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[6-(trifluoromethyl)-2-pyridyl]methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 107::US10512632, Example 107::US10766893, Example S107::US10806718, Example 107::US11026923, Example 107::US11491140, Example 107::US11634416, Example 107 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 110 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279076&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273405 378160664 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272924 CCOc1ncccc1-c1cc(NCc2cccn(C)c2=O)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-23-18(10-7-11-25-23)19-13-20(26-14-17-9-8-12-29(5)24(17)31)22-21(27-19)16(4)28-30(22)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,26,27) YLQLMBPUXKUVLD-UHFFFAOYSA-N 279077 3-[[[5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-yl]amino]methyl]-1-methyl-pyridin-2-one::US10034861, Example 108::US10512632, Example 108::US10766893, Example S108::US10806718, Example 108::US11026923, Example 108::US11491140, Example 108::US11634416, Example 108 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.80 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279077&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273406 378160665 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272927 CCOc1ncccc1-c1cc(NCc2cnn(CC)c2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H29N7O/c1-6-29-14-17(13-26-29)12-25-20-11-19(18-9-8-10-24-23(18)31-7-2)27-21-16(5)28-30(15(3)4)22(20)21/h8-11,13-15H,6-7,12H2,1-5H3,(H,25,27) IEORIQPBXNSJCP-UHFFFAOYSA-N 279078 5-(2-ethoxy-3-pyridyl)-N-[(1-ethylpyrazol-4-yl)methyl]-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 109::US10512632, Example 109::US10766893, Example S109::US10806718, Example 109::US11026923, Example 109::US11491140, Example 109::US11634416, Example 109 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4.90 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279078&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273407 378160666 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272930 CCCn1cc(CNc2cc(nc3c(C)nn(C(C)C)c23)-c2cccnc2OCC)cn1 InChI=1S/C24H31N7O/c1-6-11-30-15-18(14-27-30)13-26-21-12-20(19-9-8-10-25-24(19)32-7-2)28-22-17(5)29-31(16(3)4)23(21)22/h8-10,12,14-16H,6-7,11,13H2,1-5H3,(H,26,28) NPLKFZSTTQLUHS-UHFFFAOYSA-N 279079 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(1-propylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 110::US10512632, Example 110::US10766893, Example S110::US10806718, Example 110::US11026923, Example 110::US11491140, Example 110::US11634416, Example 110 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 11.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279079&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273408 378160667 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272933 CCOc1ncccc1-c1cc(NCc2ccc(OC)nc2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-18(8-7-11-25-24)19-12-20(26-13-17-9-10-21(31-5)27-14-17)23-22(28-19)16(4)29-30(23)15(2)3/h7-12,14-15H,6,13H2,1-5H3,(H,26,28) XMJAAWKICASNAA-UHFFFAOYSA-N 279080 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(6-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 111::US10512632, Example 111::US10766893, Example S111::US10806718, Example 111::US11026923, Example 111::US11491140, Example 111::US11634416, Example 111 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 28.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279080 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279080&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273409 378160668 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272936 CCOc1ncccc1-c1cc(NCc2ccc(OC)cn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-19(8-7-11-25-24)20-12-21(27-13-17-9-10-18(31-5)14-26-17)23-22(28-20)16(4)29-30(23)15(2)3/h7-12,14-15H,6,13H2,1-5H3,(H,27,28) HWSJSACIWPNYOB-UHFFFAOYSA-N 279081 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(5-methoxy-2-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 112::US10512632, Example 112::US10766893, Example S112::US10806718, Example 112::US11026923, Example 112::US11491140, Example 112::US11634416, Example 112 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 61.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279081&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273411 378160669 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272939 CCOc1ncccc1-c1cc(NCc2csc(C)n2)c2n(nc(C)c2n1)C1COC1 InChI=1S/C22H24N6O2S/c1-4-30-22-17(6-5-7-23-22)18-8-19(24-9-15-12-31-14(3)25-15)21-20(26-18)13(2)27-28(21)16-10-29-11-16/h5-8,12,16H,4,9-11H2,1-3H3,(H,24,26) BSSGJYYHYVLYMA-UHFFFAOYSA-N 279082 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(2-methylthiazol-4-yl)methyl]-1-(oxetan-3-yl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 113::US10512632, Example 113::US10618913, Example S113::US10766893, Example S113::US10806718, Example 113::US11026923, Example 113::US11491140, Example 113::US11634416, Example 113 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 110 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279082&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273410 378160670 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272942 CCOc1ncccc1-c1cc(NCc2cnc(OC)cn2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H27N7O2/c1-6-32-23-17(8-7-9-24-23)18-10-19(26-11-16-12-27-20(31-5)13-25-16)22-21(28-18)15(4)29-30(22)14(2)3/h7-10,12-14H,6,11H2,1-5H3,(H,26,28) QIWVSVNHRDQBOW-UHFFFAOYSA-N 279083 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(5-methoxypyrazin-2-yl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 114::US10512632, Example 114::US10766893, Example S114::US10806718, Example 114::US11026923, Example 114::US11491140, Example 114::US11634416, Example 114 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 24.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279083 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279083&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273413 378160671 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272945 CCOc1ncccc1-c1cc(NCc2cccnc2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H26N6O/c1-5-30-23-18(9-7-11-25-23)19-12-20(26-14-17-8-6-10-24-13-17)22-21(27-19)16(4)28-29(22)15(2)3/h6-13,15H,5,14H2,1-4H3,(H,26,27) MYYHBCJMEYIHMC-UHFFFAOYSA-N 279084 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(3-pyridylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 115::US10512632, Example 115::US10766893, Example S115::US10806718, Example 115::US11026923, Example 115::US11491140, Example 115::US11634416, Example 115 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 15.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279084&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273412 378160672 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272948 CCOc1ncccc1-c1cc(NCc2ccc(F)nc2)c2n(nc(C)c2n1)C(C)C InChI=1S/C23H25FN6O/c1-5-31-23-17(7-6-10-25-23)18-11-19(26-12-16-8-9-20(24)27-13-16)22-21(28-18)15(4)29-30(22)14(2)3/h6-11,13-14H,5,12H2,1-4H3,(H,26,28) SKXWAYULKGVUDE-UHFFFAOYSA-N 279085 5-(2-ethoxy-3-pyridyl)-N-[(6-fluoro-3-pyridyl)methyl]-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 116::US10512632, Example 116::US10766893, Example S116::US10806718, Example 116::US11026923, Example 116::US11491140, Example 116::US11634416, Example 116 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 21.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279085&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273414 378160673 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272951 CCOc1ncccc1-c1cc(NCc2ccc(nc2)C(F)F)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H26F2N6O/c1-5-33-24-17(7-6-10-27-24)19-11-20(22-21(30-19)15(4)31-32(22)14(2)3)29-13-16-8-9-18(23(25)26)28-12-16/h6-12,14,23H,5,13H2,1-4H3,(H,29,30) FDEJYPFAUDLEJD-UHFFFAOYSA-N 279086 N-[[6-(difluoromethyl)-3-pyridyl]methyl]-5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 117::US10512632, Example 117::US10766893, Example S117::US10806718, Example 117::US11026923, Example 117::US11491140, Example 117::US11634416, Example 117 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 18.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279086&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273416 378160674 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272954 CCOc1ncccc1-c1cc(NCc2ncccc2OC)c2n(nc(C)c2n1)C(C)C InChI=1S/C24H28N6O2/c1-6-32-24-17(9-7-12-26-24)18-13-19(27-14-20-21(31-5)10-8-11-25-20)23-22(28-18)16(4)29-30(23)15(2)3/h7-13,15H,6,14H2,1-5H3,(H,27,28) CQZGCHPJVLXYPV-UHFFFAOYSA-N 279087 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(3-methoxy-2-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 118::US10512632, Example 118::US10766893, Example S118::US10806718, Example 118::US11026923, Example 118::US11491140, Example 118::US11634416, Example 118 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 13.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279087&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273417 378160675 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272957 CCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(nc(C)c2n1)C(C)CC 279088 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 119::US10034861, Example 120::US10512632, Example 120::US10618913, Example S120::US10766893, Example S120::US10806718, Example 120::US11026923, Example 120::US11634416, Example 120 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 12.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279088&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273415 378160676 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272960 CCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(nc(C)c2n1)C(C)CC 279088 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 119::US10034861, Example 120::US10512632, Example 120::US10618913, Example S120::US10766893, Example S120::US10806718, Example 120::US11026923, Example 120::US11634416, Example 120 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4.60 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279088&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273415 378160676 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272963 CCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C22H28N8O/c1-6-14(3)30-21-18(24-12-19-25-13-29(5)28-19)11-17(26-20(21)15(4)27-30)16-9-8-10-23-22(16)31-7-2/h8-11,13-14H,6-7,12H2,1-5H3,(H,24,26) RANZHWURGHEKDD-UHFFFAOYSA-N 279090 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 121::US10034861, Example 122::US10512632, Example 122::US10766893, Example S122::US10806718, Example 122::US11634416, Example 122 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4.00 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279090&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273418 378160677 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272966 CCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C22H28N8O/c1-6-14(3)30-21-18(24-12-19-25-13-29(5)28-19)11-17(26-20(21)15(4)27-30)16-9-8-10-23-22(16)31-7-2/h8-11,13-14H,6-7,12H2,1-5H3,(H,24,26) RANZHWURGHEKDD-UHFFFAOYSA-N 279090 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 121::US10034861, Example 122::US10512632, Example 122::US10766893, Example S122::US10806718, Example 122::US11634416, Example 122 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.20 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279090&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273418 378160677 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272969 CCOc1ncccc1-c1cc(NCc2nnc(C)o2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C22H27N7O2/c1-6-13(3)29-21-18(24-12-19-27-26-15(5)31-19)11-17(25-20(21)14(4)28-29)16-9-8-10-23-22(16)30-7-2/h8-11,13H,6-7,12H2,1-5H3,(H,24,25) SJDHGTJKQKPRAR-UHFFFAOYSA-N 279092 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(5-methyl-1,3,4-oxadiazol-2-yl)methyl]-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 123::US10034861, Example 124::US10512632, Example 123::US10766893, Example S124::US10806718, Example 124::US11634416, Example 124 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 54.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279092&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273419 378160678 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272972 CCOc1ncccc1-c1cc(NCc2nnc(C)o2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C22H27N7O2/c1-6-13(3)29-21-18(24-12-19-27-26-15(5)31-19)11-17(25-20(21)14(4)28-29)16-9-8-10-23-22(16)30-7-2/h8-11,13H,6-7,12H2,1-5H3,(H,24,25) SJDHGTJKQKPRAR-UHFFFAOYSA-N 279092 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(5-methyl-1,3,4-oxadiazol-2-yl)methyl]-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 123::US10034861, Example 124::US10512632, Example 123::US10766893, Example S124::US10806718, Example 124::US11634416, Example 124 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 9.70 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279092&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273419 378160678 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272975 CCOc1ncccc1-c1cc(NCc2cncc(OC)c2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C25H30N6O2/c1-6-16(3)31-24-22(28-14-18-11-19(32-5)15-26-13-18)12-21(29-23(24)17(4)30-31)20-9-8-10-27-25(20)33-7-2/h8-13,15-16H,6-7,14H2,1-5H3,(H,28,29) SYWOKLNWWYOPHL-UHFFFAOYSA-N 279094 5-(2-ethoxy-3-pyridyl)-N-[(5-methoxy-3-pyridyl)methyl]-3-methyl-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 125::US10512632, Example 125::US10766893, Example S125::US10806718, Example 125::US11634416, Example 125 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.000 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279094&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273422 378160679 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272978 CCOc1ncccc1-c1cc(NCc2ccnc(OC)c2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C25H30N6O2/c1-6-16(3)31-24-21(28-15-18-10-12-26-22(13-18)32-5)14-20(29-23(24)17(4)30-31)19-9-8-11-27-25(19)33-7-2/h8-14,16H,6-7,15H2,1-5H3,(H,28,29) JRNBIFGQRNWOKC-UHFFFAOYSA-N 279095 5-(2-ethoxy-3-pyridyl)-N-[(2-methoxy-4-pyridyl)methyl]-3-methyl-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 126::US10512632, Example 126::US10766893, Example S126::US10806718, Example 126::US11634416, Example 126 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 5.40 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279095&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273420 378160680 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272981 CCOc1ncccc1-c1cc(NCc2nnn(C)n2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C21H27N9O/c1-6-13(3)30-20-17(23-12-18-25-28-29(5)27-18)11-16(24-19(20)14(4)26-30)15-9-8-10-22-21(15)31-7-2/h8-11,13H,6-7,12H2,1-5H3,(H,23,24) ULBLNKNNIPTFLN-UHFFFAOYSA-N 279096 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]-N-[(2-methyltetrazol-5-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 127::US10512632, Example 127::US10766893, Example S127::US10806718, Example 127::US11634416, Example 127 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.80 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279096&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273421 378160681 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272984 CCOc1ncccc1-c1cc(NCc2noc(C)n2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C22H27N7O2/c1-6-13(3)29-21-18(24-12-19-25-15(5)31-28-19)11-17(26-20(21)14(4)27-29)16-9-8-10-23-22(16)30-7-2/h8-11,13H,6-7,12H2,1-5H3,(H,24,26) XOIXJVILDWTHEL-UHFFFAOYSA-N 279097 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 128::US10512632, Example 128::US10766893, Example S128::US10806718, Example 128::US11634416, Example 128 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.20 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279097 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279097&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273425 378160682 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272987 CCOc1ncccc1-c1cc(NCc2coc(C)n2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C23H28N6O2/c1-6-14(3)29-22-20(25-12-17-13-31-16(5)26-17)11-19(27-21(22)15(4)28-29)18-9-8-10-24-23(18)30-7-2/h8-11,13-14H,6-7,12H2,1-5H3,(H,25,27) NAPUFLNYEBBQPU-UHFFFAOYSA-N 279098 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(2-methyloxazol-4-yl)methyl]-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 129::US10512632, Example 129::US10766893, Example S129::US10806718, Example 129::US11634416, Example 129 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 11.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279098 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279098&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273423 378160683 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272990 CCOc1ncccc1-c1cc(NCc2c[nH]cn2)c2n(nc(C)c2n1)C(C)CC 279099 5-(2-ethoxy-3-pyridyl)-N-(1H-imidazol-4-ylmethyl)-3-methyl-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 130::US10512632, Example 130::US10766893, Example S130::US10806718, Example 130::US11634416, Example 130 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 11.0 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279099&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273424 378160684 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272993 CCOc1ncccc1-c1cc(NCc2cc(C)[nH]n2)c2n(nc(C)c2n1)C(C)CC 279100 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]-N-[(5-methyl-1H-pyrazol-3-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 131::US10512632, Example 131::US10766893, Example S131::US10806718, Example 131::US11634416, Example 131 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.350 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279100 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279100&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273426 378160685 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 1272996 CCOc1ncccc1-c1cc(NCc2cn(C)cn2)c2n(nc(C)c2n1)C(C)CC InChI=1S/C23H29N7O/c1-6-15(3)30-22-20(25-12-17-13-29(5)14-26-17)11-19(27-21(22)16(4)28-30)18-9-8-10-24-23(18)31-7-2/h8-11,13-15H,6-7,12H2,1-5H3,(H,25,27) NIXYLBKMUOTNON-UHFFFAOYSA-N 279101 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(1-methylimidazol-4-yl)methyl]-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 132::US10512632, Example 132::US10766893, Example S132::US10806718, Example 132::US11634416, Example 132 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.140 US Patent 10.7270/Q26977HV US11634416 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgard, M; Rasmussen, LK; Clementson, CM H. Lundbeck A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279101&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 132273427 378160686 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51485026 COc1cc2CC(Cc3cccnc3)C(=O)c2cc1OCCN1CCCCC1 InChI=1S/C23H28N2O3/c1-27-21-14-18-13-19(12-17-6-5-7-24-16-17)23(26)20(18)15-22(21)28-11-10-25-8-3-2-4-9-25/h5-7,14-16,19H,2-4,8-13H2,1H3 OUWASZTUNZDMFL-UHFFFAOYSA-N 50598481 CHEMBL5193506 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A >50000 ChEMBL 10.7270/Q2K0789W 35689855 Liu, J; Liu, L; Zheng, L; Feng, KW; Wang, HT; Xu, JP; Zhou, ZZ Southern Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50598481 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50598481&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 164517091 482609333 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3 51504361 C[C@@H](OC(=O)C1=C(C)NC(C)=C(C1c1ccc2n(C)ncc2c1)C(=O)O[C@H](C)c1ccccc1)c1ccccc1 InChI=1S/C33H33N3O4/c1-20-29(32(37)39-22(3)24-12-8-6-9-13-24)31(26-16-17-28-27(18-26)19-34-36(28)5)30(21(2)35-20)33(38)40-23(4)25-14-10-7-11-15-25/h6-19,22-23,31,35H,1-5H3/t22-,23-/m1/s1 MINIPTTTZPEEKT-DHIUTWEWSA-N 50606307 CHEMBL5180169 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 145 ChEMBL 10.7270/Q2ZP4B6J 35666471 Huang, MX; Tian, YJ; Han, C; Liu, RD; Xie, X; Yuan, Y; Yang, YY; Li, Z; Chen, J; Luo, HB; Wu, Y Sun Yat-sen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50606307 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7465&target=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50606307&enzyme=Dual+specificity+calcium%2Fcalmodulin-dependent+3%27%2C5%27-cyclic+nucleotide+phosphodiesterase+1A&column=ki&startPg=0&Increment=50&submit=Search 164517159 482617158 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A_HUMAN P54750 D3DPG5 Q86VZ0 Q9C0K8 Q9C0K9 Q9C0L0 Q9C0L1 Q9C0L2 Q9C0L3 Q9C0L4 Q9UFX3