BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 789509 CC1CN(CCN1S(C)(=O)=O)c1cc(nnc1N)-c1ccccc1O InChI=1S/C16H21N5O3S/c1-11-10-20(7-8-21(11)25(2,23)24)14-9-13(18-19-16(14)17)12-5-3-4-6-15(12)22/h3-6,9,11,22H,7-8,10H2,1-2H3,(H2,17,19) RNFAVDGGNIENKQ-UHFFFAOYSA-N 394507 2-(6-amino-5-(3-methyl-4-(methylsulfonyl)piperazin-1-yl)pyridazin-3-yl)phenol::US10308614, Example 108 Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] 35.8 US Patent 10.7270/Q26112NJ aid1799026 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394507 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=691&target=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394507&enzyme=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search 137045904 405264602 1 SPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFKSARQ 2DAT,4QY4,5DKC,5DKH,6HAX,6HAY,6HAZ,7S4E,7Z6L,7Z76,7Z77,7Z78,8G1P Probable global transcription activator SNF2L2 SMCA2_HUMAN P51531 B1ALG3 B1ALG4 D3DRH4 D3DRH5 789522 CS(=O)(=O)N1CCN(CC1Cc1ccccc1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C22H25N5O3S/c1-31(29,30)27-12-11-26(15-17(27)13-16-7-3-2-4-8-16)20-14-19(24-25-22(20)23)18-9-5-6-10-21(18)28/h2-10,14,17,28H,11-13,15H2,1H3,(H2,23,25) DTWXURVEXMCFCP-UHFFFAOYSA-N 394518 2-(6-amino-5-(3-benzyl-::US10308614, Example 119 Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] 46.8 US Patent 10.7270/Q26112NJ aid1799026 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394518 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=691&target=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394518&enzyme=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search 137029513 405264613 1 SPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFKSARQ 2DAT,4QY4,5DKC,5DKH,6HAX,6HAY,6HAZ,7S4E,7Z6L,7Z76,7Z77,7Z78,8G1P Probable global transcription activator SNF2L2 SMCA2_HUMAN P51531 B1ALG3 B1ALG4 D3DRH4 D3DRH5 789527 CC1CN(CCN1C(C)=O)c1cc(nnc1N)-c1ccccc1O InChI=1S/C17H21N5O2/c1-11-10-21(7-8-22(11)12(2)23)15-9-14(19-20-17(15)18)13-5-3-4-6-16(13)24/h3-6,9,11,24H,7-8,10H2,1-2H3,(H2,18,20) FHRKRGDHMCCDEO-UHFFFAOYSA-N 394521 1-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-2-methylpiperazin-1-yl)ethanone::US10308614, Example 122 Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] 39.0 US Patent 10.7270/Q26112NJ aid1799026 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=691&target=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394521&enzyme=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search 137045912 405264616 1 SPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFKSARQ 2DAT,4QY4,5DKC,5DKH,6HAX,6HAY,6HAZ,7S4E,7Z6L,7Z76,7Z77,7Z78,8G1P Probable global transcription activator SNF2L2 SMCA2_HUMAN P51531 B1ALG3 B1ALG4 D3DRH4 D3DRH5 789536 CC1CN(CCN1C(=O)C(C)(C)C)c1cc(nnc1N)-c1ccccc1O InChI=1S/C20H27N5O2/c1-13-12-24(9-10-25(13)19(27)20(2,3)4)16-11-15(22-23-18(16)21)14-7-5-6-8-17(14)26/h5-8,11,13,26H,9-10,12H2,1-4H3,(H2,21,23) HRPWASOMWDRLHQ-UHFFFAOYSA-N 394528 1-(4-(3-amino-6-(2-::US10308614, Example 129 Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] 18.4 US Patent 10.7270/Q26112NJ aid1799026 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=691&target=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394528&enzyme=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search 137029498 405264623 1 SPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFKSARQ 2DAT,4QY4,5DKC,5DKH,6HAX,6HAY,6HAZ,7S4E,7Z6L,7Z76,7Z77,7Z78,8G1P Probable global transcription activator SNF2L2 SMCA2_HUMAN P51531 B1ALG3 B1ALG4 D3DRH4 D3DRH5 789574 CC(Oc1cc(nnc1N)-c1ccccc1O)C1CCOCC1 InChI=1S/C17H21N3O3/c1-11(12-6-8-22-9-7-12)23-16-10-14(19-20-17(16)18)13-4-2-3-5-15(13)21/h2-5,10-12,21H,6-9H2,1H3,(H2,18,20) ICVVDNFTMKQVQK-UHFFFAOYSA-N 394565 2-(6-amino-5-(1-::US10308614, Example 168 Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] 197 US Patent 10.7270/Q26112NJ aid1799026 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394565 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=691&target=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394565&enzyme=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search 137029399 405264659 1 SPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFKSARQ 2DAT,4QY4,5DKC,5DKH,6HAX,6HAY,6HAZ,7S4E,7Z6L,7Z76,7Z77,7Z78,8G1P Probable global transcription activator SNF2L2 SMCA2_HUMAN P51531 B1ALG3 B1ALG4 D3DRH4 D3DRH5 789578 C[C@H](Oc1cc(nnc1N)-c1ccccc1O)c1ccccc1 InChI=1S/C18H17N3O2/c1-12(13-7-3-2-4-8-13)23-17-11-15(20-21-18(17)19)14-9-5-6-10-16(14)22/h2-12,22H,1H3,(H2,19,21)/t12-/m0/s1 QGHVJDGMJOVMCR-LBPRGKRZSA-N 394567 (S)-2-(6-amino-5-(1-::US10308614, Example 170 Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] 14.9 US Patent 10.7270/Q26112NJ aid1799026 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394567 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=691&target=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394567&enzyme=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search 137029385 405264661 1 SPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFKSARQ 2DAT,4QY4,5DKC,5DKH,6HAX,6HAY,6HAZ,7S4E,7Z6L,7Z76,7Z77,7Z78,8G1P Probable global transcription activator SNF2L2 SMCA2_HUMAN P51531 B1ALG3 B1ALG4 D3DRH4 D3DRH5 789583 CN(C)CCOc1cc(nnc1N)-c1ccccc1O InChI=1S/C14H18N4O2/c1-18(2)7-8-20-13-9-11(16-17-14(13)15)10-5-3-4-6-12(10)19/h3-6,9,19H,7-8H2,1-2H3,(H2,15,17) SIWZRTOJDAJYHG-UHFFFAOYSA-N 394570 2-(6-amino-5-(2-::US10308614, Example 173 Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] 276 US Patent 10.7270/Q26112NJ aid1799026 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394570 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=691&target=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394570&enzyme=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search 137029363 405264664 1 SPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFKSARQ 2DAT,4QY4,5DKC,5DKH,6HAX,6HAY,6HAZ,7S4E,7Z6L,7Z76,7Z77,7Z78,8G1P Probable global transcription activator SNF2L2 SMCA2_HUMAN P51531 B1ALG3 B1ALG4 D3DRH4 D3DRH5 789586 Nc1nnc(cc1OCCc1ccccc1)-c1ccccc1O InChI=1S/C18H17N3O2/c19-18-17(23-11-10-13-6-2-1-3-7-13)12-15(20-21-18)14-8-4-5-9-16(14)22/h1-9,12,22H,10-11H2,(H2,19,21) URAFMSDXCRQVKY-UHFFFAOYSA-N 394571 2-(6-amino-5-::US10308614, Example 174 Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] 19.0 US Patent 10.7270/Q26112NJ aid1799026 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394571 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=691&target=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394571&enzyme=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search 137045937 405264665 1 SPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFKSARQ 2DAT,4QY4,5DKC,5DKH,6HAX,6HAY,6HAZ,7S4E,7Z6L,7Z76,7Z77,7Z78,8G1P Probable global transcription activator SNF2L2 SMCA2_HUMAN P51531 B1ALG3 B1ALG4 D3DRH4 D3DRH5 789591 CC(Cc1ccccc1)Oc1cc(nnc1N)-c1ccccc1O InChI=1S/C19H19N3O2/c1-13(11-14-7-3-2-4-8-14)24-18-12-16(21-22-19(18)20)15-9-5-6-10-17(15)23/h2-10,12-13,23H,11H2,1H3,(H2,20,22) LAMLMRYWDMUTPN-UHFFFAOYSA-N 394574 2-(6-amino-5-((1-::US10308614, Example 177 Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] 92.5 US Patent 10.7270/Q26112NJ aid1799026 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394574 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=691&target=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394574&enzyme=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search 137029380 405264668 1 SPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFKSARQ 2DAT,4QY4,5DKC,5DKH,6HAX,6HAY,6HAZ,7S4E,7Z6L,7Z76,7Z77,7Z78,8G1P Probable global transcription activator SNF2L2 SMCA2_HUMAN P51531 B1ALG3 B1ALG4 D3DRH4 D3DRH5 789594 CC(COc1cc(nnc1N)-c1ccccc1O)c1ccccc1 InChI=1S/C19H19N3O2/c1-13(14-7-3-2-4-8-14)12-24-18-11-16(21-22-19(18)20)15-9-5-6-10-17(15)23/h2-11,13,23H,12H2,1H3,(H2,20,22) VVYATDRFTFUUGA-UHFFFAOYSA-N 394575 2-(6-amino-5-(2-::US10308614, Example 178 Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] 7.20 US Patent 10.7270/Q26112NJ aid1799026 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=691&target=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394575&enzyme=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search 137029410 405264669 1 SPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFKSARQ 2DAT,4QY4,5DKC,5DKH,6HAX,6HAY,6HAZ,7S4E,7Z6L,7Z76,7Z77,7Z78,8G1P Probable global transcription activator SNF2L2 SMCA2_HUMAN P51531 B1ALG3 B1ALG4 D3DRH4 D3DRH5 789598 Nc1nnc(cc1OC1CCN(Cc2ccccc2)C1)-c1ccccc1O InChI=1S/C21H22N4O2/c22-21-20(12-18(23-24-21)17-8-4-5-9-19(17)26)27-16-10-11-25(14-16)13-15-6-2-1-3-7-15/h1-9,12,16,26H,10-11,13-14H2,(H2,22,24) BTCGLYACXJHVJC-UHFFFAOYSA-N 394577 2-(6-amino-5-((1-::US10308614, Example 180 Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] 59.7 US Patent 10.7270/Q26112NJ aid1799026 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394577 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=691&target=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394577&enzyme=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search 137029505 405264671 1 SPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFKSARQ 2DAT,4QY4,5DKC,5DKH,6HAX,6HAY,6HAZ,7S4E,7Z6L,7Z76,7Z77,7Z78,8G1P Probable global transcription activator SNF2L2 SMCA2_HUMAN P51531 B1ALG3 B1ALG4 D3DRH4 D3DRH5 789606 Nc1nnc(cc1-c1ccccc1)-c1ccccc1O InChI=1S/C16H13N3O/c17-16-13(11-6-2-1-3-7-11)10-14(18-19-16)12-8-4-5-9-15(12)20/h1-10,20H,(H2,17,19) SDAWPVIWTVUTCC-UHFFFAOYSA-N 394583 2-(6-amino-5-phenylpyridazin-3-yl)phenol::US10308614, Example 186 Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] 37.3 US Patent 10.7270/Q26112NJ aid1799026 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394583 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=691&target=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394583&enzyme=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search GGU 7TAB 137045897 405264677 1 SPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFKSARQ 2DAT,4QY4,5DKC,5DKH,6HAX,6HAY,6HAZ,7S4E,7Z6L,7Z76,7Z77,7Z78,8G1P Probable global transcription activator SNF2L2 SMCA2_HUMAN P51531 B1ALG3 B1ALG4 D3DRH4 D3DRH5 789609 Cn1cc(cn1)-c1cc(nnc1N)-c1ccccc1O InChI=1S/C14H13N5O/c1-19-8-9(7-16-19)11-6-12(17-18-14(11)15)10-4-2-3-5-13(10)20/h2-8,20H,1H3,(H2,15,18) JISLSABSHWDDTJ-UHFFFAOYSA-N 394584 2-(6-amino-5-(1-methyl-::US10308614, Example 187 Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] 10.00 US Patent 10.7270/Q26112NJ aid1799026 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394584 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=691&target=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394584&enzyme=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search 137029367 405264678 1 SPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFKSARQ 2DAT,4QY4,5DKC,5DKH,6HAX,6HAY,6HAZ,7S4E,7Z6L,7Z76,7Z77,7Z78,8G1P Probable global transcription activator SNF2L2 SMCA2_HUMAN P51531 B1ALG3 B1ALG4 D3DRH4 D3DRH5 789612 CC(c1ccccc1)n1cc(cn1)-c1cc(nnc1N)-c1ccccc1O InChI=1S/C21H19N5O/c1-14(15-7-3-2-4-8-15)26-13-16(12-23-26)18-11-19(24-25-21(18)22)17-9-5-6-10-20(17)27/h2-14,27H,1H3,(H2,22,25) GSAKHYJGZSBABY-UHFFFAOYSA-N 394585 2-(6-amino-5-(1-(1-::US10308614, Example 188 Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] 5.70 US Patent 10.7270/Q26112NJ aid1799026 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394585 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=691&target=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394585&enzyme=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search 137029401 405264679 1 SPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFKSARQ 2DAT,4QY4,5DKC,5DKH,6HAX,6HAY,6HAZ,7S4E,7Z6L,7Z76,7Z77,7Z78,8G1P Probable global transcription activator SNF2L2 SMCA2_HUMAN P51531 B1ALG3 B1ALG4 D3DRH4 D3DRH5 789615 CN(C)Cc1ccc(cc1)-c1cc(nnc1N)-c1ccccc1O InChI=1S/C19H20N4O/c1-23(2)12-13-7-9-14(10-8-13)16-11-17(21-22-19(16)20)15-5-3-4-6-18(15)24/h3-11,24H,12H2,1-2H3,(H2,20,22) COKXUIZUCWUEQS-UHFFFAOYSA-N 394586 2-(6-amino-5-(4-::US10308614, Example 189 Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] 49.3 US Patent 10.7270/Q26112NJ aid1799026 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394586 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=691&target=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394586&enzyme=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search 137029365 405264680 1 SPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFKSARQ 2DAT,4QY4,5DKC,5DKH,6HAX,6HAY,6HAZ,7S4E,7Z6L,7Z76,7Z77,7Z78,8G1P Probable global transcription activator SNF2L2 SMCA2_HUMAN P51531 B1ALG3 B1ALG4 D3DRH4 D3DRH5 789631 CNc1ccc(nn1)-c1ccccc1O InChI=1S/C11H11N3O/c1-12-11-7-6-9(13-14-11)8-4-2-3-5-10(8)15/h2-7,15H,1H3,(H,12,14) UWHKFKASLJRTNP-UHFFFAOYSA-N 394600 2-(6-(methylamino)pyridazin-3-yl)phenol::US10308614, Example 204 Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] 1040 US Patent 10.7270/Q26112NJ aid1799026 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394600 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=691&target=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394600&enzyme=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search 136145557 405264694 1 SPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFKSARQ 2DAT,4QY4,5DKC,5DKH,6HAX,6HAY,6HAZ,7S4E,7Z6L,7Z76,7Z77,7Z78,8G1P Probable global transcription activator SNF2L2 SMCA2_HUMAN P51531 B1ALG3 B1ALG4 D3DRH4 D3DRH5 789635 Nc1nnc(cc1-c1ccccc1)-c1cccc(F)c1O InChI=1S/C16H12FN3O/c17-13-8-4-7-11(15(13)21)14-9-12(16(18)20-19-14)10-5-2-1-3-6-10/h1-9,21H,(H2,18,20) YIQNHNMFVVDQQU-UHFFFAOYSA-N 394602 2-(6-amino-5-phenylpyridazin-3-yl)-6-fluorophenol::US10308614, Example 206 Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] 320 US Patent 10.7270/Q26112NJ aid1799026 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=691&target=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394602&enzyme=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search 137045957 405264696 1 SPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFKSARQ 2DAT,4QY4,5DKC,5DKH,6HAX,6HAY,6HAZ,7S4E,7Z6L,7Z76,7Z77,7Z78,8G1P Probable global transcription activator SNF2L2 SMCA2_HUMAN P51531 B1ALG3 B1ALG4 D3DRH4 D3DRH5 789640 Nc1nnc(cc1C1CCCCC1)-c1ccccc1O InChI=1S/C16H19N3O/c17-16-13(11-6-2-1-3-7-11)10-14(18-19-16)12-8-4-5-9-15(12)20/h4-5,8-11,20H,1-3,6-7H2,(H2,17,19) QMIHYQHNCMLKCV-UHFFFAOYSA-N 394605 2-(6-amino-5-cyclohexylpyridazin-3-yl)phenol::US10308614, Example 209 Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] 8.80 US Patent 10.7270/Q26112NJ aid1799026 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394605 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=691&target=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394605&enzyme=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search 137045919 405264699 1 SPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFKSARQ 2DAT,4QY4,5DKC,5DKH,6HAX,6HAY,6HAZ,7S4E,7Z6L,7Z76,7Z77,7Z78,8G1P Probable global transcription activator SNF2L2 SMCA2_HUMAN P51531 B1ALG3 B1ALG4 D3DRH4 D3DRH5 789643 Nc1nnc(cc1C1CCCC1)-c1ccccc1O InChI=1S/C15H17N3O/c16-15-12(10-5-1-2-6-10)9-13(17-18-15)11-7-3-4-8-14(11)19/h3-4,7-10,19H,1-2,5-6H2,(H2,16,18) AKIDLWUESNUXNK-UHFFFAOYSA-N 394606 2-(6-amino-5-::US10308614, Example 210 Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] 25.0 US Patent 10.7270/Q26112NJ aid1799026 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394606 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=691&target=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394606&enzyme=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search 137029376 405264700 1 SPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFKSARQ 2DAT,4QY4,5DKC,5DKH,6HAX,6HAY,6HAZ,7S4E,7Z6L,7Z76,7Z77,7Z78,8G1P Probable global transcription activator SNF2L2 SMCA2_HUMAN P51531 B1ALG3 B1ALG4 D3DRH4 D3DRH5 789652 Nc1nnc(cc1C1CCN(C1)S(=O)(=O)c1ccccc1)-c1ccccc1O InChI=1S/C20H20N4O3S/c21-20-17(12-18(22-23-20)16-8-4-5-9-19(16)25)14-10-11-24(13-14)28(26,27)15-6-2-1-3-7-15/h1-9,12,14,25H,10-11,13H2,(H2,21,23) LTOWBWFTKOUSOO-UHFFFAOYSA-N 394613 2-(6-amino-5-(1-(phenylsulfonyl)pyrrolidin-3-yl)pyridazin-3-yl)phenol::US10308614, Example 217 Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] 466 US Patent 10.7270/Q26112NJ aid1799026 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394613 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=691&target=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394613&enzyme=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search 137045922 405264707 1 SPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFKSARQ 2DAT,4QY4,5DKC,5DKH,6HAX,6HAY,6HAZ,7S4E,7Z6L,7Z76,7Z77,7Z78,8G1P Probable global transcription activator SNF2L2 SMCA2_HUMAN P51531 B1ALG3 B1ALG4 D3DRH4 D3DRH5 789655 Nc1nnc(cc1C1CCN(Cc2ccccc2)CC1)-c1ccccc1O InChI=1S/C22H24N4O/c23-22-19(14-20(24-25-22)18-8-4-5-9-21(18)27)17-10-12-26(13-11-17)15-16-6-2-1-3-7-16/h1-9,14,17,27H,10-13,15H2,(H2,23,25) NSAUQIQMBFHQRE-UHFFFAOYSA-N 394614 2-(6-amino-5-(1-benzylpiperidin-4-yl)pyridazin-3-yl)phenol::US10308614, Example 218 Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] 39.3 US Patent 10.7270/Q26112NJ aid1799026 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394614 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=691&target=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394614&enzyme=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search 137029557 405264708 1 SPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFKSARQ 2DAT,4QY4,5DKC,5DKH,6HAX,6HAY,6HAZ,7S4E,7Z6L,7Z76,7Z77,7Z78,8G1P Probable global transcription activator SNF2L2 SMCA2_HUMAN P51531 B1ALG3 B1ALG4 D3DRH4 D3DRH5 789385 Nc1nnc(cc1N1CCN(Cc2cccnc2)CC1)-c1ccccc1O InChI=1S/C20H22N6O/c21-20-18(12-17(23-24-20)16-5-1-2-6-19(16)27)26-10-8-25(9-11-26)14-15-4-3-7-22-13-15/h1-7,12-13,27H,8-11,14H2,(H2,21,24) JZLOJEOBZZJRHN-UHFFFAOYSA-N 394401 2-(6-amino-5-(4-(pyridin-::US10308614, Example 3 Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] 60.7 US Patent 10.7270/Q26112NJ aid1799026 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394401 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=691&target=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394401&enzyme=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search 137029368 405264499 1 SPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFKSARQ 2DAT,4QY4,5DKC,5DKH,6HAX,6HAY,6HAZ,7S4E,7Z6L,7Z76,7Z77,7Z78,8G1P Probable global transcription activator SNF2L2 SMCA2_HUMAN P51531 B1ALG3 B1ALG4 D3DRH4 D3DRH5 789388 CC(=O)N1CCN(CC1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C16H19N5O2/c1-11(22)20-6-8-21(9-7-20)14-10-13(18-19-16(14)17)12-4-2-3-5-15(12)23/h2-5,10,23H,6-9H2,1H3,(H2,17,19) SPSLNCYVKLGTKH-UHFFFAOYSA-N 394402 1-(4-(3-amino-6-(2-::US10308614, Example 4 Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] 71.7 US Patent 10.7270/Q26112NJ aid1799026 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394402 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=691&target=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394402&enzyme=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search 137029408 405264500 1 SPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFKSARQ 2DAT,4QY4,5DKC,5DKH,6HAX,6HAY,6HAZ,7S4E,7Z6L,7Z76,7Z77,7Z78,8G1P Probable global transcription activator SNF2L2 SMCA2_HUMAN P51531 B1ALG3 B1ALG4 D3DRH4 D3DRH5 789391 CN(C)CC1CCN(CC1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C18H25N5O/c1-22(2)12-13-7-9-23(10-8-13)16-11-15(20-21-18(16)19)14-5-3-4-6-17(14)24/h3-6,11,13,24H,7-10,12H2,1-2H3,(H2,19,21) NCSVRIYOFWYLNA-UHFFFAOYSA-N 394403 2-(6-amino-5-(4-((dimethylami-::US10308614, Example 5 Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] 22.5 US Patent 10.7270/Q26112NJ aid1799026 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394403 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=691&target=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394403&enzyme=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search 137029396 405264501 1 SPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFKSARQ 2DAT,4QY4,5DKC,5DKH,6HAX,6HAY,6HAZ,7S4E,7Z6L,7Z76,7Z77,7Z78,8G1P Probable global transcription activator SNF2L2 SMCA2_HUMAN P51531 B1ALG3 B1ALG4 D3DRH4 D3DRH5 789397 Nc1nnc(cc1N1C[C@@H]2CN(Cc3ccccc3)C[C@@H]2C1)-c1ccccc1O InChI=1S/C23H25N5O/c24-23-21(10-20(25-26-23)19-8-4-5-9-22(19)29)28-14-17-12-27(13-18(17)15-28)11-16-6-2-1-3-7-16/h1-10,17-18,29H,11-15H2,(H2,24,26)/t17-,18+ HYFYBIOFAMANIC-HDICACEKSA-N 394408 2-(6-amino-5-((3aR,6aS)-5-::US10308614, Example 9 Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] 47.6 US Patent 10.7270/Q26112NJ aid1799026 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394408 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=691&target=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394408&enzyme=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search 137029430 405264506 1 SPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFKSARQ 2DAT,4QY4,5DKC,5DKH,6HAX,6HAY,6HAZ,7S4E,7Z6L,7Z76,7Z77,7Z78,8G1P Probable global transcription activator SNF2L2 SMCA2_HUMAN P51531 B1ALG3 B1ALG4 D3DRH4 D3DRH5 789405 CC(N1CCN(CC1)c1cc(nnc1N)-c1ccccc1O)c1ccccc1 InChI=1S/C22H25N5O/c1-16(17-7-3-2-4-8-17)26-11-13-27(14-12-26)20-15-19(24-25-22(20)23)18-9-5-6-10-21(18)28/h2-10,15-16,28H,11-14H2,1H3,(H2,23,25) MBDFNLARUDVNEJ-UHFFFAOYSA-N 394414 2-(6-amino-5-(4-(1-::US10308614, Example 15 Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] 36.1 US Patent 10.7270/Q26112NJ aid1799026 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394414 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=691&target=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394414&enzyme=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search 137029510 405264512 1 SPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFKSARQ 2DAT,4QY4,5DKC,5DKH,6HAX,6HAY,6HAZ,7S4E,7Z6L,7Z76,7Z77,7Z78,8G1P Probable global transcription activator SNF2L2 SMCA2_HUMAN P51531 B1ALG3 B1ALG4 D3DRH4 D3DRH5 789408 Nc1nnc(cc1N1CC2CCC(C1)N2Cc1ccccc1)-c1ccccc1O InChI=1S/C23H25N5O/c24-23-21(12-20(25-26-23)19-8-4-5-9-22(19)29)27-14-17-10-11-18(15-27)28(17)13-16-6-2-1-3-7-16/h1-9,12,17-18,29H,10-11,13-15H2,(H2,24,26) VZDXUFDLQRAMEG-UHFFFAOYSA-N 394415 2-(6-amino-5-(8-benzyl-3,8-::US10308614, Example 16 Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] 79.0 US Patent 10.7270/Q26112NJ aid1799026 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=691&target=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394415&enzyme=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search 137029512 405264513 1 SPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFKSARQ 2DAT,4QY4,5DKC,5DKH,6HAX,6HAY,6HAZ,7S4E,7Z6L,7Z76,7Z77,7Z78,8G1P Probable global transcription activator SNF2L2 SMCA2_HUMAN P51531 B1ALG3 B1ALG4 D3DRH4 D3DRH5 789427 CC1CN(CC(C)O1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C16H20N4O2/c1-10-8-20(9-11(2)22-10)14-7-13(18-19-16(14)17)12-5-3-4-6-15(12)21/h3-7,10-11,21H,8-9H2,1-2H3,(H2,17,19) LTQBMPHICDLNOB-UHFFFAOYSA-N 394432 2-(6-amino-5-(2,6-::US10308614, Example 33 Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] 69.6 US Patent 10.7270/Q26112NJ aid1799026 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=691&target=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394432&enzyme=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search 137029414 405264530 1 SPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFKSARQ 2DAT,4QY4,5DKC,5DKH,6HAX,6HAY,6HAZ,7S4E,7Z6L,7Z76,7Z77,7Z78,8G1P Probable global transcription activator SNF2L2 SMCA2_HUMAN P51531 B1ALG3 B1ALG4 D3DRH4 D3DRH5 789441 Nc1nnc(cc1N1CCOCC1)-c1ccccc1O InChI=1S/C14H16N4O2/c15-14-12(18-5-7-20-8-6-18)9-11(16-17-14)10-3-1-2-4-13(10)19/h1-4,9,19H,5-8H2,(H2,15,17) JEKZPGPLMPQKGR-UHFFFAOYSA-N 394444 2-(6-amino-5-::US10308614, Example 45 Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] 71.5 US Patent 10.7270/Q26112NJ aid1799026 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394444 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=691&target=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394444&enzyme=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search 137029366 405264542 1 SPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFKSARQ 2DAT,4QY4,5DKC,5DKH,6HAX,6HAY,6HAZ,7S4E,7Z6L,7Z76,7Z77,7Z78,8G1P Probable global transcription activator SNF2L2 SMCA2_HUMAN P51531 B1ALG3 B1ALG4 D3DRH4 D3DRH5 789455 Nc1nnc(cc1N1CC(C1)Oc1ccccc1)-c1ccccc1O InChI=1S/C19H18N4O2/c20-19-17(10-16(21-22-19)15-8-4-5-9-18(15)24)23-11-14(12-23)25-13-6-2-1-3-7-13/h1-10,14,24H,11-12H2,(H2,20,22) SFMYKATXFFQSND-UHFFFAOYSA-N 394456 2-(6-amino-5-(3-::US10308614, Example 57 Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] 35.6 US Patent 10.7270/Q26112NJ aid1799026 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394456 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=691&target=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394456&enzyme=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search 137029437 405264553 1 SPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFKSARQ 2DAT,4QY4,5DKC,5DKH,6HAX,6HAY,6HAZ,7S4E,7Z6L,7Z76,7Z77,7Z78,8G1P Probable global transcription activator SNF2L2 SMCA2_HUMAN P51531 B1ALG3 B1ALG4 D3DRH4 D3DRH5 789490 Nc1nnc(cc1N1CCCCC1)-c1ccccc1O InChI=1S/C15H18N4O/c16-15-13(19-8-4-1-5-9-19)10-12(17-18-15)11-6-2-3-7-14(11)20/h2-3,6-7,10,20H,1,4-5,8-9H2,(H2,16,18) RJVQZTLPHCJXNB-UHFFFAOYSA-N 394490 2-(6-amino-5-(piperidin-1-yl)pyridazin-3-yl)phenol::US10308614, Example 90 Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] 45.9 US Patent 10.7270/Q26112NJ aid1799026 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394490 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=691&target=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394490&enzyme=Isoform+Short+of+Probable+global+transcription+activator+SNF2L2+%28Short%29+377-1486%5D&column=ki&startPg=0&Increment=50&submit=Search 137045907 405264585 1 SPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFKSARQ 2DAT,4QY4,5DKC,5DKH,6HAX,6HAY,6HAZ,7S4E,7Z6L,7Z76,7Z77,7Z78,8G1P Probable global transcription activator SNF2L2 SMCA2_HUMAN P51531 B1ALG3 B1ALG4 D3DRH4 D3DRH5