BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 789495 CC(C)n1cc(CN2CCN(CC2)c2cc(nnc2N)-c2ccccc2O)cn1 InChI=1S/C21H27N7O/c1-15(2)28-14-16(12-23-28)13-26-7-9-27(10-8-26)19-11-18(24-25-21(19)22)17-5-3-4-6-20(17)29/h3-6,11-12,14-15,29H,7-10,13H2,1-2H3,(H2,22,25) CXARMQHIABHRMS-UHFFFAOYSA-N 394494 2-[6-amino-5-[4-[(1-isopropylpyrazol-4-yl)methyl]piperazin-1-yl]pyridazin-3-yl]phenol::US10308614, Example 94 Transcription activator BRG1 [1448-1575] 122 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394494 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394494&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137045975 405264589 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789496 Nc1nnc(cc1N1CCN(Cc2cccc(c2)C#N)CC1)-c1ccccc1O InChI=1S/C22H22N6O/c23-14-16-4-3-5-17(12-16)15-27-8-10-28(11-9-27)20-13-19(25-26-22(20)24)18-6-1-2-7-21(18)29/h1-7,12-13,29H,8-11,15H2,(H2,24,26) LXGMUOJJLRKKGV-UHFFFAOYSA-N 394495 3-[[4-[3-amino-6-(2-::US10308614, Example 96 Transcription activator BRG1 [1448-1575] 56.9 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394495&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029555 405264590 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789497 Nc1nnc(cc1N1CCN(Cc2ncco2)CC1)-c1ccccc1O InChI=1S/C18H20N6O2/c19-18-15(11-14(21-22-18)13-3-1-2-4-16(13)25)24-8-6-23(7-9-24)12-17-20-5-10-26-17/h1-5,10-11,25H,6-9,12H2,(H2,19,22) IBDNSFWVEZWBIP-UHFFFAOYSA-N 394496 2-[6-amino-5-[4-::US10308614, Example 97 Transcription activator BRG1 [1448-1575] 71.4 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394496&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029415 405264591 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789498 Nc1nnc(cc1N1CCN(Cc2ccncc2)CC1)-c1ccccc1O InChI=1S/C20H22N6O/c21-20-18(13-17(23-24-20)16-3-1-2-4-19(16)27)26-11-9-25(10-12-26)14-15-5-7-22-8-6-15/h1-8,13,27H,9-12,14H2,(H2,21,24) GGDOHNPBEXMUJQ-UHFFFAOYSA-N 394497 2-[6-amino-5-[4-(4-::US10308614, Example 98 Transcription activator BRG1 [1448-1575] 79.6 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394497&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029558 405264592 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789499 Cn1ccnc1CN1CCN(CC1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C19H23N7O/c1-24-7-6-21-18(24)13-25-8-10-26(11-9-25)16-12-15(22-23-19(16)20)14-4-2-3-5-17(14)27/h2-7,12,27H,8-11,13H2,1H3,(H2,20,23) NLNFRPIGZCNAFV-UHFFFAOYSA-N 394498 2-[6-amino-5-[4-[(1-::US10308614, Example 99 Transcription activator BRG1 [1448-1575] 32.4 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394498 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394498&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029561 405264593 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789500 Cn1ccc(CN2CCN(CC2)c2cc(nnc2N)-c2ccccc2O)n1 InChI=1S/C19H23N7O/c1-24-7-6-14(23-24)13-25-8-10-26(11-9-25)17-12-16(21-22-19(17)20)15-4-2-3-5-18(15)27/h2-7,12,27H,8-11,13H2,1H3,(H2,20,22) UEPWWNHGCVUHOX-UHFFFAOYSA-N 394499 2-[6-amino-5-[4-[(1-::US10308614, Example 100 Transcription activator BRG1 [1448-1575] 38.0 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394499&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029519 405264594 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789501 Cc1cc(CN2CCN(CC2)c2cc(nnc2N)-c2ccccc2O)no1 InChI=1S/C19H22N6O2/c1-13-10-14(23-27-13)12-24-6-8-25(9-7-24)17-11-16(21-22-19(17)20)15-4-2-3-5-18(15)26/h2-5,10-11,26H,6-9,12H2,1H3,(H2,20,22) QBAQQFMEXXBYQW-UHFFFAOYSA-N 394500 2-[6-amino-5-[4-[(5-::US10308614, Example 101 Transcription activator BRG1 [1448-1575] 65.3 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394500&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029523 405264595 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789502 Nc1nnc(cc1N1CCN(Cc2n[nH]c3ccccc23)CC1)-c1ccccc1O InChI=1S/C22H23N7O/c23-22-20(13-18(25-27-22)16-6-2-4-8-21(16)30)29-11-9-28(10-12-29)14-19-15-5-1-3-7-17(15)24-26-19/h1-8,13,30H,9-12,14H2,(H2,23,27)(H,24,26) MDQVBCINKFASRA-UHFFFAOYSA-N 394501 2-[6-amino-5-[4-(1H-::US10308614, Example 102 Transcription activator BRG1 [1448-1575] 25.9 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394501&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 146047779 405264596 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789503 Cn1ncc2c(CN3CCN(CC3)c3cc(nnc3N)-c3ccccc3O)cccc12 InChI=1S/C23H25N7O/c1-28-20-7-4-5-16(18(20)14-25-28)15-29-9-11-30(12-10-29)21-13-19(26-27-23(21)24)17-6-2-3-8-22(17)31/h2-8,13-14,31H,9-12,15H2,1H3,(H2,24,27) BXFSSZSKMPYDMF-UHFFFAOYSA-N 394502 2-[6-amino-5-[4-[(1-::US10308614, Example 103 Transcription activator BRG1 [1448-1575] 28.9 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394502&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029417 405264597 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789504 Cc1nc(CN2CCN(CC2)c2cc(nnc2N)-c2ccccc2O)co1 InChI=1S/C19H22N6O2/c1-13-21-14(12-27-13)11-24-6-8-25(9-7-24)17-10-16(22-23-19(17)20)15-4-2-3-5-18(15)26/h2-5,10,12,26H,6-9,11H2,1H3,(H2,20,23) ZJESBRKVBQYZBF-UHFFFAOYSA-N 394503 2-[6-amino-5-[4-[(2-::US10308614, Example 104 Transcription activator BRG1 [1448-1575] 56.9 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394503 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394503&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029418 405264598 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789505 Cn1ncc2cc(CN3CCN(CC3)c3cc(nnc3N)-c3ccccc3O)ccc12 InChI=1S/C23H25N7O/c1-28-20-7-6-16(12-17(20)14-25-28)15-29-8-10-30(11-9-29)21-13-19(26-27-23(21)24)18-4-2-3-5-22(18)31/h2-7,12-14,31H,8-11,15H2,1H3,(H2,24,27) BXDJJCULDWLNFA-UHFFFAOYSA-N 394504 2-[6-amino-5-[4-[(1-::US10308614, Example 105 Transcription activator BRG1 [1448-1575] 27.9 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394504&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029419 405264599 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789506 CC(C)(C)OC(=O)N1CCc2cc(CN3CCN(CC3)c3cc(nnc3N)-c3ccccc3O)ccc12 InChI=1S/C28H34N6O3/c1-28(2,3)37-27(36)34-11-10-20-16-19(8-9-23(20)34)18-32-12-14-33(15-13-32)24-17-22(30-31-26(24)29)21-6-4-5-7-25(21)35/h4-9,16-17,35H,10-15,18H2,1-3H3,(H2,29,31) XHVWTOHLLLXHCA-UHFFFAOYSA-N 394505 US10308614, Example 106::tert-butyl 5-[[4-[3- Transcription activator BRG1 [1448-1575] 689 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394505 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394505&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029422 405264600 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789507 Cn1cc(CN2CCN(CC2)c2cc(nnc2N)-c2ccccc2O)cn1 InChI=1S/C19H23N7O/c1-24-12-14(11-21-24)13-25-6-8-26(9-7-25)17-10-16(22-23-19(17)20)15-4-2-3-5-18(15)27/h2-5,10-12,27H,6-9,13H2,1H3,(H2,20,23) WLDXZOOYBMRQKC-UHFFFAOYSA-N 394506 2-[6-amino-5-[4-[(1-::US10308614, Example 107 Transcription activator BRG1 [1448-1575] 87.7 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394506 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394506&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029420 405264601 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789508 CC1CN(CCN1S(C)(=O)=O)c1cc(nnc1N)-c1ccccc1O InChI=1S/C16H21N5O3S/c1-11-10-20(7-8-21(11)25(2,23)24)14-9-13(18-19-16(14)17)12-5-3-4-6-15(12)22/h3-6,9,11,22H,7-8,10H2,1-2H3,(H2,17,19) RNFAVDGGNIENKQ-UHFFFAOYSA-N 394507 2-(6-amino-5-(3-methyl-4-(methylsulfonyl)piperazin-1-yl)pyridazin-3-yl)phenol::US10308614, Example 108 Transcription activator BRG1 [1448-1575] 31.0 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394507 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394507&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137045904 405264602 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789511 CC1CN(CCN1S(=O)(=O)c1ccccc1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C21H23N5O3S/c1-15-14-25(11-12-26(15)30(28,29)16-7-3-2-4-8-16)19-13-18(23-24-21(19)22)17-9-5-6-10-20(17)27/h2-10,13,15,27H,11-12,14H2,1H3,(H2,22,24) YDVWGKBKYLCXKQ-UHFFFAOYSA-N 394508 2-(6-amino-5-(3-methyl-::US10308614, Example 109 Transcription activator BRG1 [1448-1575] 17.6 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394508 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394508&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029424 405264603 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789512 CCS(=O)(=O)N1CCN(CC1C)c1cc(nnc1N)-c1ccccc1O InChI=1S/C17H23N5O3S/c1-3-26(24,25)22-9-8-21(11-12(22)2)15-10-14(19-20-17(15)18)13-6-4-5-7-16(13)23/h4-7,10,12,23H,3,8-9,11H2,1-2H3,(H2,18,20) ZFOZGLWEUFREAD-UHFFFAOYSA-N 394509 2-(6-amino-5-(4-::US10308614, Example 110 Transcription activator BRG1 [1448-1575] 21.9 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394509 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394509&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029492 405264604 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789513 CC1CN(CCN1S(=O)(=O)C1CC1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C18H23N5O3S/c1-12-11-22(8-9-23(12)27(25,26)13-6-7-13)16-10-15(20-21-18(16)19)14-4-2-3-5-17(14)24/h2-5,10,12-13,24H,6-9,11H2,1H3,(H2,19,21) IEGZWXJBFIKDGX-UHFFFAOYSA-N 394510 2-(6-amino-5-(4-::US10308614, Example 111 Transcription activator BRG1 [1448-1575] 19.7 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394510 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394510&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029425 405264605 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789514 CC1(C)CN(CCN1S(C)(=O)=O)c1cc(nnc1N)-c1ccccc1O InChI=1S/C17H23N5O3S/c1-17(2)11-21(8-9-22(17)26(3,24)25)14-10-13(19-20-16(14)18)12-6-4-5-7-15(12)23/h4-7,10,23H,8-9,11H2,1-3H3,(H2,18,20) PQTUJEPFIKCUSN-UHFFFAOYSA-N 394511 2-(6-amino-5-(3,3-::US10308614, Example 112 Transcription activator BRG1 [1448-1575] 30.7 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394511 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394511&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029497 405264606 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789515 C[C@H]1CN(C[C@H](C)N1S(C)=O)c1cc(nnc1N)-c1ccccc1O InChI=1S/C17H23N5O2S/c1-11-9-21(10-12(2)22(11)25(3)24)15-8-14(19-20-17(15)18)13-6-4-5-7-16(13)23/h4-8,11-12,23H,9-10H2,1-3H3,(H2,18,20)/t11-,12-,25?/m0/s1 PFYNEYJTIWVNHG-BUPPPZHISA-N 394512 2-(6-amino-5-((3S,5S)-::US10308614, Example 113 Transcription activator BRG1 [1448-1575] 263 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394512 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394512&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029426 405264607 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789516 C[C@@H]1CN(C[C@@H](C)N1S(C)=O)c1cc(nnc1N)-c1ccccc1O InChI=1S/C17H23N5O2S/c1-11-9-21(10-12(2)22(11)25(3)24)15-8-14(19-20-17(15)18)13-6-4-5-7-16(13)23/h4-8,11-12,23H,9-10H2,1-3H3,(H2,18,20)/t11-,12-,25?/m1/s1 PFYNEYJTIWVNHG-VXEBNURSSA-N 394513 2-(6-amino-5-((3R,5R)-::US10308614, Example 114 Transcription activator BRG1 [1448-1575] 51.5 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394513 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394513&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137291353 405264608 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789517 C[C@H]1CN(CCN1S(C)(=O)=O)c1cc(nnc1N)-c1ccccc1O InChI=1S/C16H21N5O3S/c1-11-10-20(7-8-21(11)25(2,23)24)14-9-13(18-19-16(14)17)12-5-3-4-6-15(12)22/h3-6,9,11,22H,7-8,10H2,1-2H3,(H2,17,19)/t11-/m0/s1 RNFAVDGGNIENKQ-NSHDSACASA-N 394514 (S)-2-(6-amino-5-(3-::US10308614, Example 115 Transcription activator BRG1 [1448-1575] 63.6 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394514&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029548 405264609 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789518 C[C@@H]1CN(CCN1S(C)(=O)=O)c1cc(nnc1N)-c1ccccc1O InChI=1S/C16H21N5O3S/c1-11-10-20(7-8-21(11)25(2,23)24)14-9-13(18-19-16(14)17)12-5-3-4-6-15(12)22/h3-6,9,11,22H,7-8,10H2,1-2H3,(H2,17,19)/t11-/m1/s1 RNFAVDGGNIENKQ-LLVKDONJSA-N 394515 (R)-2-(6-amino-5-(3-::US10308614, Example 116 Transcription activator BRG1 [1448-1575] 37.0 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394515&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029508 405264610 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789519 COCCS(=O)(=O)N1CCN(C[C@H]1C)c1cc(nnc1N)-c1ccccc1O InChI=1S/C18H25N5O4S/c1-13-12-22(7-8-23(13)28(25,26)10-9-27-2)16-11-15(20-21-18(16)19)14-5-3-4-6-17(14)24/h3-6,11,13,24H,7-10,12H2,1-2H3,(H2,19,21)/t13-/m1/s1 SMXKTQHRQJLDRU-CYBMUJFWSA-N 394516 (R)-2-(6-amino-5-(4-((2-::US10308614, Example 117 Transcription activator BRG1 [1448-1575] 53.5 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394516 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394516&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029404 405264611 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789520 C[C@@H]1CN(CCN1S(=O)(=O)c1nccn1C)c1cc(nnc1N)-c1ccccc1O InChI=1S/C19H23N7O3S/c1-13-12-25(9-10-26(13)30(28,29)19-21-7-8-24(19)2)16-11-15(22-23-18(16)20)14-5-3-4-6-17(14)27/h3-8,11,13,27H,9-10,12H2,1-2H3,(H2,20,23)/t13-/m1/s1 PDOBWSWFCLNRAY-CYBMUJFWSA-N 394517 (R)-2-(6-amino-5-(3-::US10308614, Example 118 Transcription activator BRG1 [1448-1575] 28.1 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394517 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394517&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029369 405264612 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789521 CS(=O)(=O)N1CCN(CC1Cc1ccccc1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C22H25N5O3S/c1-31(29,30)27-12-11-26(15-17(27)13-16-7-3-2-4-8-16)20-14-19(24-25-22(20)23)18-9-5-6-10-21(18)28/h2-10,14,17,28H,11-13,15H2,1H3,(H2,23,25) DTWXURVEXMCFCP-UHFFFAOYSA-N 394518 2-(6-amino-5-(3-benzyl-::US10308614, Example 119 Transcription activator BRG1 [1448-1575] 38.5 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394518 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394518&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029513 405264613 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789524 CC(C)(O)C(=O)N1C2CCC1CN(C2)c1cc(nnc1N)-c1ccccc1O InChI=1S/C20H25N5O3/c1-20(2,28)19(27)25-12-7-8-13(25)11-24(10-12)16-9-15(22-23-18(16)21)14-5-3-4-6-17(14)26/h3-6,9,12-13,26,28H,7-8,10-11H2,1-2H3,(H2,21,23) GHVXBTIACJKSKK-UHFFFAOYSA-N 394519 1-(3-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)-2-hydroxy-2-methylpropan-1-one::US10308614, Example 120 Transcription activator BRG1 [1448-1575] 44.4 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394519 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394519&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137045946 405264614 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789525 CN(C)C(=O)N1C2CCC1CN(C2)c1cc(nnc1N)-c1ccccc1O InChI=1S/C19H24N6O2/c1-23(2)19(27)25-12-7-8-13(25)11-24(10-12)16-9-15(21-22-18(16)20)14-5-3-4-6-17(14)26/h3-6,9,12-13,26H,7-8,10-11H2,1-2H3,(H2,20,22) HBZXGZNCRIGZJE-UHFFFAOYSA-N 394520 3-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-N,N-dimethyl-3,8-diazabicyclo[3.2.1]octane-8-carboxamide::US10308614, Example 121 Transcription activator BRG1 [1448-1575] 22.5 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394520 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394520&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137045902 405264615 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789526 CC1CN(CCN1C(C)=O)c1cc(nnc1N)-c1ccccc1O InChI=1S/C17H21N5O2/c1-11-10-21(7-8-22(11)12(2)23)15-9-14(19-20-17(15)18)13-5-3-4-6-16(13)24/h3-6,9,11,24H,7-8,10H2,1-2H3,(H2,18,20) FHRKRGDHMCCDEO-UHFFFAOYSA-N 394521 1-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-2-methylpiperazin-1-yl)ethanone::US10308614, Example 122 Transcription activator BRG1 [1448-1575] 39.6 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394521&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137045912 405264616 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789529 CC1CN(CCN1C(=O)c1c(C)noc1C)c1cc(nnc1N)-c1ccccc1O InChI=1S/C21H24N6O3/c1-12-11-26(8-9-27(12)21(29)19-13(2)25-30-14(19)3)17-10-16(23-24-20(17)22)15-6-4-5-7-18(15)28/h4-7,10,12,28H,8-9,11H2,1-3H3,(H2,22,24) ZJSNAGQDJVPCNZ-UHFFFAOYSA-N 394522 (4-(3-amino-6-(2-::US10308614, Example 123 Transcription activator BRG1 [1448-1575] 87.9 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394522 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394522&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029480 405264617 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789530 CC1CN(CCN1C(=O)C1CC1c1ccccc1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C25H27N5O2/c1-16-15-29(22-14-21(27-28-24(22)26)18-9-5-6-10-23(18)31)11-12-30(16)25(32)20-13-19(20)17-7-3-2-4-8-17/h2-10,14,16,19-20,31H,11-13,15H2,1H3,(H2,26,28) DTHWXEZIYQVRES-UHFFFAOYSA-N 394523 (4-(3-amino-6-(2-::US10308614, Example 124 Transcription activator BRG1 [1448-1575] 25.8 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394523 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394523&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029522 405264618 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789531 CC1CN(CCN1C(=O)Cc1ccccn1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C22H24N6O2/c1-15-14-27(10-11-28(15)21(30)12-16-6-4-5-9-24-16)19-13-18(25-26-22(19)23)17-7-2-3-8-20(17)29/h2-9,13,15,29H,10-12,14H2,1H3,(H2,23,26) VHNHMSGXIIEVAR-UHFFFAOYSA-N 394524 1-(4-(3-amino-6-(2-::US10308614, Example 125 Transcription activator BRG1 [1448-1575] 42.6 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394524 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394524&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029481 405264619 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789532 Nc1nnc(cc1N1CC2CCC(C1)N2C(=O)c1cncs1)-c1ccccc1O InChI=1S/C20H20N6O2S/c21-19-16(7-15(23-24-19)14-3-1-2-4-17(14)27)25-9-12-5-6-13(10-25)26(12)20(28)18-8-22-11-29-18/h1-4,7-8,11-13,27H,5-6,9-10H2,(H2,21,24) NTWYBAVHVOGHBD-UHFFFAOYSA-N 394525 (3-(3-amino-6-(2-::US10308614, Example 126 Transcription activator BRG1 [1448-1575] 20.3 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394525 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394525&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029379 405264620 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789533 C[C@H]1CN(C[C@H](C)N1C(C)=O)c1cc(nnc1N)-c1ccccc1O InChI=1S/C18H23N5O2/c1-11-9-22(10-12(2)23(11)13(3)24)16-8-15(20-21-18(16)19)14-6-4-5-7-17(14)25/h4-8,11-12,25H,9-10H2,1-3H3,(H2,19,21)/t11-,12-/m0/s1 FMHVFIMJCARZJZ-RYUDHWBXSA-N 394526 1-((2S,6S)-4-(3-amino-6-::US10308614, Example 127 Transcription activator BRG1 [1448-1575] 369 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394526&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029466 405264621 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789534 C[C@@H]1CN(C[C@@H](C)N1C(C)=O)c1cc(nnc1N)-c1ccccc1O InChI=1S/C18H23N5O2/c1-11-9-22(10-12(2)23(11)13(3)24)16-8-15(20-21-18(16)19)14-6-4-5-7-17(14)25/h4-8,11-12,25H,9-10H2,1-3H3,(H2,19,21)/t11-,12-/m1/s1 FMHVFIMJCARZJZ-VXGBXAGGSA-N 394527 1-((2R,6R)-4-(3-amino-::US10308614, Example 128 Transcription activator BRG1 [1448-1575] 505 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394527 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394527&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029449 405264622 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789535 CC1CN(CCN1C(=O)C(C)(C)C)c1cc(nnc1N)-c1ccccc1O InChI=1S/C20H27N5O2/c1-13-12-24(9-10-25(13)19(27)20(2,3)4)16-11-15(22-23-18(16)21)14-7-5-6-8-17(14)26/h5-8,11,13,26H,9-10,12H2,1-4H3,(H2,21,23) HRPWASOMWDRLHQ-UHFFFAOYSA-N 394528 1-(4-(3-amino-6-(2-::US10308614, Example 129 Transcription activator BRG1 [1448-1575] 10.4 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394528&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029498 405264623 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789538 CC(=O)N1CCN(CC1(C)C)c1cc(nnc1N)-c1ccccc1O InChI=1S/C18H23N5O2/c1-12(24)23-9-8-22(11-18(23,2)3)15-10-14(20-21-17(15)19)13-6-4-5-7-16(13)25/h4-7,10,25H,8-9,11H2,1-3H3,(H2,19,21) DBNSQEZQVVNLEM-UHFFFAOYSA-N 394529 1-(4-(3-amino-6-(2-::US10308614, Example 130 Transcription activator BRG1 [1448-1575] 75.0 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394529 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394529&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029487 405264624 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789539 C[C@@H]1CN(CCN1C(C)=O)c1cc(nnc1N)-c1ccccc1O InChI=1S/C17H21N5O2/c1-11-10-21(7-8-22(11)12(2)23)15-9-14(19-20-17(15)18)13-5-3-4-6-16(13)24/h3-6,9,11,24H,7-8,10H2,1-2H3,(H2,18,20)/t11-/m1/s1 FHRKRGDHMCCDEO-LLVKDONJSA-N 394530 (R)-1-(4-(3-amino-6-(2-::US10308614, Example 131 Transcription activator BRG1 [1448-1575] 34.6 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394530&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029447 405264625 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789540 C[C@H]1CN(CCN1C(C)=O)c1cc(nnc1N)-c1ccccc1O InChI=1S/C17H21N5O2/c1-11-10-21(7-8-22(11)12(2)23)15-9-14(19-20-17(15)18)13-5-3-4-6-16(13)24/h3-6,9,11,24H,7-8,10H2,1-2H3,(H2,18,20)/t11-/m0/s1 FHRKRGDHMCCDEO-NSHDSACASA-N 394531 (S)-1-(4-(3-amino-6-(2-::US10308614, Example 132 Transcription activator BRG1 [1448-1575] 119 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394531&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029390 405264626 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789541 CC1CN(CCN1C(=O)C1(C)COC1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C20H25N5O3/c1-13-10-24(7-8-25(13)19(27)20(2)11-28-12-20)16-9-15(22-23-18(16)21)14-5-3-4-6-17(14)26/h3-6,9,13,26H,7-8,10-12H2,1-2H3,(H2,21,23) FTLXSWBPYNWGCK-UHFFFAOYSA-N 394532 (4-(3-amino-6-(2-::US10308614, Example 133 Transcription activator BRG1 [1448-1575] 67.0 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394532&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029518 405264627 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789542 CC1CN(CCN1C(=O)C(C)(C)O)c1cc(nnc1N)-c1ccccc1O InChI=1S/C19H25N5O3/c1-12-11-23(8-9-24(12)18(26)19(2,3)27)15-10-14(21-22-17(15)20)13-6-4-5-7-16(13)25/h4-7,10,12,25,27H,8-9,11H2,1-3H3,(H2,20,22) XTIIYVFZJVOMKQ-UHFFFAOYSA-N 394533 1-(4-(3-amino-6-(2-::US10308614, Example 134 Transcription activator BRG1 [1448-1575] 34.9 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394533&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029509 405264628 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789543 CC1CN(CCN1C(=O)c1cccnc1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C21H22N6O2/c1-14-13-26(9-10-27(14)21(29)15-5-4-8-23-12-15)18-11-17(24-25-20(18)22)16-6-2-3-7-19(16)28/h2-8,11-12,14,28H,9-10,13H2,1H3,(H2,22,25) WSWDIDIRVDTXAP-UHFFFAOYSA-N 394534 (4-(3-amino-6-(2-::US10308614, Example 135 Transcription activator BRG1 [1448-1575] 44.6 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394534&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029524 405264629 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789544 CC1CN(CCN1C(=O)Cc1cc(C)no1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C21H24N6O3/c1-13-9-15(30-25-13)10-20(29)27-8-7-26(12-14(27)2)18-11-17(23-24-21(18)22)16-5-3-4-6-19(16)28/h3-6,9,11,14,28H,7-8,10,12H2,1-2H3,(H2,22,24) RMXZORSDITXHAW-UHFFFAOYSA-N 394535 1-(4-(3-amino-6-(2-::US10308614, Example 136 Transcription activator BRG1 [1448-1575] 44.4 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394535&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029493 405264630 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789545 Nc1nnc(cc1N1CCN(CC1)C(=O)c1ccncn1)-c1ccccc1O InChI=1S/C19H19N7O2/c20-18-16(11-15(23-24-18)13-3-1-2-4-17(13)27)25-7-9-26(10-8-25)19(28)14-5-6-21-12-22-14/h1-6,11-12,27H,7-10H2,(H2,20,24) QAPQNPOQTQCYFE-UHFFFAOYSA-N 394536 (4-(3-amino-6-(2-::US10308614, Example 137 Transcription activator BRG1 [1448-1575] 38.9 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394536 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394536&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137291354 405264631 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789546 CC1CN(CCN1C(=O)c1cncs1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C19H20N6O2S/c1-12-10-24(6-7-25(12)19(27)17-9-21-11-28-17)15-8-14(22-23-18(15)20)13-4-2-3-5-16(13)26/h2-5,8-9,11-12,26H,6-7,10H2,1H3,(H2,20,23) PTYLPTAZYUKCTI-UHFFFAOYSA-N 394537 (4-(3-amino-6-(2-::US10308614, Example 138 Transcription activator BRG1 [1448-1575] 12.6 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394537 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394537&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029488 405264632 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789547 C[C@H]1CN(C[C@@H](C)N1C(C)=O)c1cc(nnc1N)-c1ccccc1O InChI=1S/C18H23N5O2/c1-11-9-22(10-12(2)23(11)13(3)24)16-8-15(20-21-18(16)19)14-6-4-5-7-17(14)25/h4-8,11-12,25H,9-10H2,1-3H3,(H2,19,21)/t11-,12+ FMHVFIMJCARZJZ-TXEJJXNPSA-N 394538 1-((2S,6R)-4-(3-amino-6-::US10308614, Example 139 Transcription activator BRG1 [1448-1575] 106 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394538 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394538&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029490 405264633 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789548 CC(C)[C@H](N)C(=O)N1CCN(CC1C)c1cc(nnc1N)-c1ccccc1O InChI=1S/C20H28N6O2/c1-12(2)18(21)20(28)26-9-8-25(11-13(26)3)16-10-15(23-24-19(16)22)14-6-4-5-7-17(14)27/h4-7,10,12-13,18,27H,8-9,11,21H2,1-3H3,(H2,22,24)/t13?,18-/m0/s1 LQNRGUWFGCXMHB-UWBLVGDVSA-N 394539 (2S)-2-amino-1-(4-(3-::US10308614, Example 140 Transcription activator BRG1 [1448-1575] 47.5 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394539 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394539&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029468 405264634 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789549 C[C@@H]1CN(CCN1C(=O)[C@@H]1CCCO1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C20H25N5O3/c1-13-12-24(8-9-25(13)20(27)18-7-4-10-28-18)16-11-15(22-23-19(16)21)14-5-2-3-6-17(14)26/h2-3,5-6,11,13,18,26H,4,7-10,12H2,1H3,(H2,21,23)/t13-,18+/m1/s1 JRKMOIZQFDOZBT-ACJLOTCBSA-N 394540 ((R)-4-(3-amino-6-(2-::US10308614, Example 141 Transcription activator BRG1 [1448-1575] 33.0 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394540 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394540&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029525 405264635 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789550 C[C@H]1CN(CCN1C(=O)[C@@H]1CCCO1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C20H25N5O3/c1-13-12-24(8-9-25(13)20(27)18-7-4-10-28-18)16-11-15(22-23-19(16)21)14-5-2-3-6-17(14)26/h2-3,5-6,11,13,18,26H,4,7-10,12H2,1H3,(H2,21,23)/t13-,18-/m0/s1 JRKMOIZQFDOZBT-UGSOOPFHSA-N 394541 ((S)-4-(3-amino-6-(2-::US10308614, Example 142 Transcription activator BRG1 [1448-1575] 97.5 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394541 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394541&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029521 405264636 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789551 Nc1nnc(cc1N1CCN(C(CO)C1)C(=O)c1cncs1)-c1ccccc1O InChI=1S/C19H20N6O3S/c20-18-15(7-14(22-23-18)13-3-1-2-4-16(13)27)24-5-6-25(12(9-24)10-26)19(28)17-8-21-11-29-17/h1-4,7-8,11-12,26-27H,5-6,9-10H2,(H2,20,23) JHRGZYTZACMRJO-UHFFFAOYSA-N 394542 (4-(3-amino-6-(2-::US10308614, Example 143 Transcription activator BRG1 [1448-1575] 20.6 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394542&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029462 405264637 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789552 CC(=O)N1CCN(CC1Cc1ccccc1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C23H25N5O2/c1-16(29)28-12-11-27(15-18(28)13-17-7-3-2-4-8-17)21-14-20(25-26-23(21)24)19-9-5-6-10-22(19)30/h2-10,14,18,30H,11-13,15H2,1H3,(H2,24,26) XFBSSWRILFNOBS-UHFFFAOYSA-N 394543 1-(4-(3-amino-6-(2-::US10308614, Example 144 Transcription activator BRG1 [1448-1575] 29.7 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394543 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394543&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137045969 405264638 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789553 C[C@@H]1CN(CCN1C(=O)C(C)(C)O)c1cc(nnc1N)-c1ccccc1O InChI=1S/C19H25N5O3/c1-12-11-23(8-9-24(12)18(26)19(2,3)27)15-10-14(21-22-17(15)20)13-6-4-5-7-16(13)25/h4-7,10,12,25,27H,8-9,11H2,1-3H3,(H2,20,22)/t12-/m1/s1 XTIIYVFZJVOMKQ-GFCCVEGCSA-N 394544 (R)-1-(4-(3-amino-6-(2-::US10308614, Example 145 Transcription activator BRG1 [1448-1575] 64.2 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394544 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394544&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029530 405264639 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789554 C[C@H]1CN(CCN1C(=O)C(C)(C)O)c1cc(nnc1N)-c1ccccc1O InChI=1S/C19H25N5O3/c1-12-11-23(8-9-24(12)18(26)19(2,3)27)15-10-14(21-22-17(15)20)13-6-4-5-7-16(13)25/h4-7,10,12,25,27H,8-9,11H2,1-3H3,(H2,20,22)/t12-/m0/s1 XTIIYVFZJVOMKQ-LBPRGKRZSA-N 394545 (S)-1-(4-(3-amino-6-(2-::US10308614, Example 146 Transcription activator BRG1 [1448-1575] 45.8 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394545 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394545&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029423 405264640 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789555 CNC(=O)C(C)N1CCN(C[C@H]1C)c1cc(nnc1N)-c1ccccc1O InChI=1S/C19H26N6O2/c1-12-11-24(8-9-25(12)13(2)19(27)21-3)16-10-15(22-23-18(16)20)14-6-4-5-7-17(14)26/h4-7,10,12-13,26H,8-9,11H2,1-3H3,(H2,20,23)(H,21,27)/t12-,13?/m1/s1 FCFNLMHNKCLMPF-PZORYLMUSA-N 394546 2-((R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-2-methylpiperazin-1-yl)-N-methylpropanamide::US10308614, Example 147::US10308614, Example 159 Transcription activator BRG1 [1448-1575] 26.8 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394546 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394546&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137045930 405264641 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789556 CNC(=O)CN1CCN(C[C@H]1C)c1cc(nnc1N)-c1ccccc1O InChI=1S/C18H24N6O2/c1-12-10-24(8-7-23(12)11-17(26)20-2)15-9-14(21-22-18(15)19)13-5-3-4-6-16(13)25/h3-6,9,12,25H,7-8,10-11H2,1-2H3,(H2,19,22)(H,20,26)/t12-/m1/s1 JAPZFHUHQHAJME-GFCCVEGCSA-N 394547 (R)-2-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-2-methylpiperazin-1-yl)-N-methylacetamide::US10308614, Example 148 Transcription activator BRG1 [1448-1575] 61.3 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394547 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394547&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137045924 405264642 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789557 CC(=O)N1CCN(C[C@@H]1Cc1ccccc1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C23H25N5O2/c1-16(29)28-12-11-27(15-18(28)13-17-7-3-2-4-8-17)21-14-20(25-26-23(21)24)19-9-5-6-10-22(19)30/h2-10,14,18,30H,11-13,15H2,1H3,(H2,24,26)/t18-/m0/s1 XFBSSWRILFNOBS-SFHVURJKSA-N 394548 Enantiomer 1 and enantiomer 2 of 1-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-2-benzylpiperazin-1-yl)ethanone::US10308614, Example 149 Transcription activator BRG1 [1448-1575] 86.9 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394548 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394548&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029421 405264643 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789558 CC(=O)N1CCN(C[C@H]1Cc1ccccc1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C23H25N5O2/c1-16(29)28-12-11-27(15-18(28)13-17-7-3-2-4-8-17)21-14-20(25-26-23(21)24)19-9-5-6-10-22(19)30/h2-10,14,18,30H,11-13,15H2,1H3,(H2,24,26)/t18-/m1/s1 XFBSSWRILFNOBS-GOSISDBHSA-N 394549 Enantiomer 1 and enantiomer 2 of 1-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-2-benzylpiperazin-1-yl)ethanone::US10308614, Example 150 Transcription activator BRG1 [1448-1575] 58.4 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394549 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394549&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029373 405264644 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789559 C[C@H]1CN(CCN1C(=O)c1ccncn1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C20H21N7O2/c1-13-11-26(8-9-27(13)20(29)15-6-7-22-12-23-15)17-10-16(24-25-19(17)21)14-4-2-3-5-18(14)28/h2-7,10,12-13,28H,8-9,11H2,1H3,(H2,21,25)/t13-/m0/s1 QRHWPEWRCMJDHF-ZDUSSCGKSA-N 394550 Enantiomer 1 and enantiomer 2 of (4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-2-methylpiperazin-1-yl)(pyrimidin-4-yl)methanone::US10308614, Example 153 Transcription activator BRG1 [1448-1575] 202 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394550 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394550&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029587 405264645 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789560 C[C@@H]1CN(CCN1C(=O)c1ccncn1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C20H21N7O2/c1-13-11-26(8-9-27(13)20(29)15-6-7-22-12-23-15)17-10-16(24-25-19(17)21)14-4-2-3-5-18(14)28/h2-7,10,12-13,28H,8-9,11H2,1H3,(H2,21,25)/t13-/m1/s1 QRHWPEWRCMJDHF-CYBMUJFWSA-N 394551 Enantiomer 1 and enantiomer 2 of (4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-2-methylpiperazin-1-yl)(pyrimidin-4-yl)methanone::US10308614, Example 154 Transcription activator BRG1 [1448-1575] 49.6 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394551 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394551&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029586 405264646 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789561 C[C@H]1CN(CCN1C(=O)c1cccnc1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C21H22N6O2/c1-14-13-26(9-10-27(14)21(29)15-5-4-8-23-12-15)18-11-17(24-25-20(18)22)16-6-2-3-7-19(16)28/h2-8,11-12,14,28H,9-10,13H2,1H3,(H2,22,25)/t14-/m0/s1 WSWDIDIRVDTXAP-AWEZNQCLSA-N 394552 US10308614, Example 155::[(2S)-4-[3-amino-6- (2- hydroxyphenyl) pyridazin-4-yl]-2- methyl-piperazin-1- yl]-(3- pyridyl)methanone Transcription activator BRG1 [1448-1575] 166 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394552&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029583 405264647 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789562 C[C@@H]1CN(CCN1C(=O)c1cccnc1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C21H22N6O2/c1-14-13-26(9-10-27(14)21(29)15-5-4-8-23-12-15)18-11-17(24-25-20(18)22)16-6-2-3-7-19(16)28/h2-8,11-12,14,28H,9-10,13H2,1H3,(H2,22,25)/t14-/m1/s1 WSWDIDIRVDTXAP-CQSZACIVSA-N 394553 US10308614, Example 156::[(2R)-4-[3-amino-6- (2- hydroxyphenyl) pyridazin-4-yl]-2- methyl-piperazin-1- yl]-(3- pyridyl)methanone Transcription activator BRG1 [1448-1575] 43.5 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394553 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394553&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029552 405264648 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789563 CC(C)[C@H](N)C(=O)N1CCN(C[C@H]1C)c1cc(nnc1N)-c1ccccc1O InChI=1S/C20H28N6O2/c1-12(2)18(21)20(28)26-9-8-25(11-13(26)3)16-10-15(23-24-19(16)22)14-6-4-5-7-17(14)27/h4-7,10,12-13,18,27H,8-9,11,21H2,1-3H3,(H2,22,24)/t13-,18+/m1/s1 LQNRGUWFGCXMHB-ACJLOTCBSA-N 394554 (2S)-2-amino-1- [(2R)-4-[3-amino-6- (2- hydroxyphenyl) pyridazin-4-yl]-2- methyl-piperazin-1- yl]-3-methyl-butan- 1-one::US10308614, Example 157 Transcription activator BRG1 [1448-1575] 29.6 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394554 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394554&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029554 405264649 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789564 CC(C)[C@H](N)C(=O)N1CCN(C[C@@H]1C)c1cc(nnc1N)-c1ccccc1O InChI=1S/C20H28N6O2/c1-12(2)18(21)20(28)26-9-8-25(11-13(26)3)16-10-15(23-24-19(16)22)14-6-4-5-7-17(14)27/h4-7,10,12-13,18,27H,8-9,11,21H2,1-3H3,(H2,22,24)/t13-,18-/m0/s1 LQNRGUWFGCXMHB-UGSOOPFHSA-N 394555 (2S)-2-amino-1- [(2S)-4-[3-amino-6- (2- hydroxyphenyl) pyridazin-4-yl]-2- methyl-piperazin-1- yl]-3-methyl-butan- 1-one::US10308614, Example 158 Transcription activator BRG1 [1448-1575] 112 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394555&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029549 405264650 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789565 CNC(=O)C(C)N1CCN(C[C@H]1C)c1cc(nnc1N)-c1ccccc1O InChI=1S/C19H26N6O2/c1-12-11-24(8-9-25(12)13(2)19(27)21-3)16-10-15(22-23-18(16)20)14-6-4-5-7-17(14)26/h4-7,10,12-13,26H,8-9,11H2,1-3H3,(H2,20,23)(H,21,27)/t12-,13?/m1/s1 FCFNLMHNKCLMPF-PZORYLMUSA-N 394546 2-((R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-2-methylpiperazin-1-yl)-N-methylpropanamide::US10308614, Example 147::US10308614, Example 159 Transcription activator BRG1 [1448-1575] 27.0 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394546 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394546&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137045930 405264641 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789566 CNCC(=O)N1CCN(CC1C)c1cc(nnc1N)-c1ccccc1O InChI=1S/C18H24N6O2/c1-12-11-23(7-8-24(12)17(26)10-20-2)15-9-14(21-22-18(15)19)13-5-3-4-6-16(13)25/h3-6,9,12,20,25H,7-8,10-11H2,1-2H3,(H2,19,22) JOIXHVFZSUECOJ-UHFFFAOYSA-N 394557 1-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-2-methylpiperazin-1-yl)-2-(methylamino)ethanone and 1-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-2-methylpiperazin-1-yl)-2-(dimethylamino)ethanone::US10308614, Example 161 Transcription activator BRG1 [1448-1575] 46.0 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394557 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394557&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137045910 405264651 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789567 CC1CN(CCN1C(=O)CN(C)C)c1cc(nnc1N)-c1ccccc1O InChI=1S/C19H26N6O2/c1-13-11-24(8-9-25(13)18(27)12-23(2)3)16-10-15(21-22-19(16)20)14-6-4-5-7-17(14)26/h4-7,10,13,26H,8-9,11-12H2,1-3H3,(H2,20,22) OWDBDJLMYKEFHP-UHFFFAOYSA-N 394558 1-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-2-methylpiperazin-1-yl)-2-(methylamino)ethanone and 1-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-2-methylpiperazin-1-yl)-2-(dimethylamino)ethanone::US10308614, Example 162 Transcription activator BRG1 [1448-1575] 58.6 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394558&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137045923 405264652 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789568 CC(Oc1cc(nnc1N)-c1ccccc1O)c1ccccc1 InChI=1S/C18H17N3O2/c1-12(13-7-3-2-4-8-13)23-17-11-15(20-21-18(17)19)14-9-5-6-10-16(14)22/h2-12,22H,1H3,(H2,19,21) QGHVJDGMJOVMCR-UHFFFAOYSA-N 394559 2-(6-amino-5-(1-phenylethoxy)pyridazin-3-yl)phenol::US10308614, Example 163 Transcription activator BRG1 [1448-1575] 55.1 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394559 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394559&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137045935 405264653 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789569 CC(Oc1cc(nnc1N)-c1ccccc1O)C(C)(C)C InChI=1S/C16H21N3O2/c1-10(16(2,3)4)21-14-9-12(18-19-15(14)17)11-7-5-6-8-13(11)20/h5-10,20H,1-4H3,(H2,17,19) MIYRHUMMZVAKMP-UHFFFAOYSA-N 394560 2-(6-amino-5-((3,3-::US10308614, Example 164 Transcription activator BRG1 [1448-1575] 143 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394560&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029395 405264654 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789570 Nc1nnc(cc1O[C@H]1CCCC[C@@H]1c1ccccc1)-c1ccccc1O InChI=1S/C22H23N3O2/c23-22-21(14-18(24-25-22)17-11-4-6-12-19(17)26)27-20-13-7-5-10-16(20)15-8-2-1-3-9-15/h1-4,6,8-9,11-12,14,16,20,26H,5,7,10,13H2,(H2,23,25)/t16-,20+/m1/s1 GSYORJHMGCDAFW-UZLBHIALSA-N 394561 2-(6-amino-5-(((1,2-::US10308614, Example 165 Transcription activator BRG1 [1448-1575] 977 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394561 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394561&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029386 405264655 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789571 C[C@@H](Oc1cc(nnc1N)-c1ccccc1O)c1cccnc1 InChI=1S/C17H16N4O2/c1-11(12-5-4-8-19-10-12)23-16-9-14(20-21-17(16)18)13-6-2-3-7-15(13)22/h2-11,22H,1H3,(H2,18,21)/t11-/m1/s1 NKBIWHYIOAQJBB-LLVKDONJSA-N 394562 (R)-2-(6-amino-5-(1-::US10308614, Example 166 Transcription activator BRG1 [1448-1575] 132 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394562 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394562&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029457 405264656 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789572 C[C@H](Oc1cc(nnc1N)-c1ccccc1O)c1cccnc1 InChI=1S/C17H16N4O2/c1-11(12-5-4-8-19-10-12)23-16-9-14(20-21-17(16)18)13-6-2-3-7-15(13)22/h2-11,22H,1H3,(H2,18,21)/t11-/m0/s1 NKBIWHYIOAQJBB-NSHDSACASA-N 394564 (S)-2-(6-amino-5-(1-::US10308614, Example 167 Transcription activator BRG1 [1448-1575] 25.1 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394564&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029459 405264658 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789573 CC(Oc1cc(nnc1N)-c1ccccc1O)C1CCOCC1 InChI=1S/C17H21N3O3/c1-11(12-6-8-22-9-7-12)23-16-10-14(19-20-17(16)18)13-4-2-3-5-15(13)21/h2-5,10-12,21H,6-9H2,1H3,(H2,18,20) ICVVDNFTMKQVQK-UHFFFAOYSA-N 394565 2-(6-amino-5-(1-::US10308614, Example 168 Transcription activator BRG1 [1448-1575] 169 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394565 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394565&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029399 405264659 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789576 C[C@@H](Oc1cc(nnc1N)-c1ccccc1O)c1ccccc1 InChI=1S/C18H17N3O2/c1-12(13-7-3-2-4-8-13)23-17-11-15(20-21-18(17)19)14-9-5-6-10-16(14)22/h2-12,22H,1H3,(H2,19,21)/t12-/m1/s1 QGHVJDGMJOVMCR-GFCCVEGCSA-N 394566 (R)-2-(6-amino-5-(1-::US10308614, Example 169 Transcription activator BRG1 [1448-1575] 227 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394566 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394566&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029378 405264660 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789577 C[C@H](Oc1cc(nnc1N)-c1ccccc1O)c1ccccc1 InChI=1S/C18H17N3O2/c1-12(13-7-3-2-4-8-13)23-17-11-15(20-21-18(17)19)14-9-5-6-10-16(14)22/h2-12,22H,1H3,(H2,19,21)/t12-/m0/s1 QGHVJDGMJOVMCR-LBPRGKRZSA-N 394567 (S)-2-(6-amino-5-(1-::US10308614, Example 170 Transcription activator BRG1 [1448-1575] 36.8 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394567 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394567&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029385 405264661 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789580 CC(Oc1cc(nnc1N)-c1ccccc1O)c1cccnc1 InChI=1S/C17H16N4O2/c1-11(12-5-4-8-19-10-12)23-16-9-14(20-21-17(16)18)13-6-2-3-7-15(13)22/h2-11,22H,1H3,(H2,18,21) NKBIWHYIOAQJBB-UHFFFAOYSA-N 394568 2-(6-amino-5-(1-(pyridin-::US10308614, Example 171 Transcription activator BRG1 [1448-1575] 79.2 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394568&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029394 405264662 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789581 CN1CCC(CC1)Oc1cc(nnc1N)-c1ccccc1O InChI=1S/C16H20N4O2/c1-20-8-6-11(7-9-20)22-15-10-13(18-19-16(15)17)12-4-2-3-5-14(12)21/h2-5,10-11,21H,6-9H2,1H3,(H2,17,19) MWHDPPUPTJDPDF-UHFFFAOYSA-N 394569 2-(6-amino-5-((1-::US10308614, Example 172 Transcription activator BRG1 [1448-1575] 161 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394569 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394569&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029393 405264663 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789582 CN(C)CCOc1cc(nnc1N)-c1ccccc1O InChI=1S/C14H18N4O2/c1-18(2)7-8-20-13-9-11(16-17-14(13)15)10-5-3-4-6-12(10)19/h3-6,9,19H,7-8H2,1-2H3,(H2,15,17) SIWZRTOJDAJYHG-UHFFFAOYSA-N 394570 2-(6-amino-5-(2-::US10308614, Example 173 Transcription activator BRG1 [1448-1575] 263 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394570 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394570&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029363 405264664 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789585 Nc1nnc(cc1OCCc1ccccc1)-c1ccccc1O InChI=1S/C18H17N3O2/c19-18-17(23-11-10-13-6-2-1-3-7-13)12-15(20-21-18)14-8-4-5-9-16(14)22/h1-9,12,22H,10-11H2,(H2,19,21) URAFMSDXCRQVKY-UHFFFAOYSA-N 394571 2-(6-amino-5-::US10308614, Example 174 Transcription activator BRG1 [1448-1575] 14.8 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394571 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394571&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137045937 405264665 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789588 CN(C)CCCOc1cc(nnc1N)-c1ccccc1O InChI=1S/C15H20N4O2/c1-19(2)8-5-9-21-14-10-12(17-18-15(14)16)11-6-3-4-7-13(11)20/h3-4,6-7,10,20H,5,8-9H2,1-2H3,(H2,16,18) KNWHWYSWKPDTAP-UHFFFAOYSA-N 394572 2-(6-amino-5-(3-::US10308614, Example 175 Transcription activator BRG1 [1448-1575] 117 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394572 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394572&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029382 405264666 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789589 Nc1nnc(cc1OC1CCCC1)-c1ccccc1O InChI=1S/C15H17N3O2/c16-15-14(20-10-5-1-2-6-10)9-12(17-18-15)11-7-3-4-8-13(11)19/h3-4,7-10,19H,1-2,5-6H2,(H2,16,18) YCMHVCWWHJJYBT-UHFFFAOYSA-N 394573 2-(6-amino-5-::US10308614, Example 176 Transcription activator BRG1 [1448-1575] 37.1 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394573 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394573&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029501 405264667 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789590 CC(Cc1ccccc1)Oc1cc(nnc1N)-c1ccccc1O InChI=1S/C19H19N3O2/c1-13(11-14-7-3-2-4-8-14)24-18-12-16(21-22-19(18)20)15-9-5-6-10-17(15)23/h2-10,12-13,23H,11H2,1H3,(H2,20,22) LAMLMRYWDMUTPN-UHFFFAOYSA-N 394574 2-(6-amino-5-((1-::US10308614, Example 177 Transcription activator BRG1 [1448-1575] 100 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394574 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394574&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029380 405264668 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789593 CC(COc1cc(nnc1N)-c1ccccc1O)c1ccccc1 InChI=1S/C19H19N3O2/c1-13(14-7-3-2-4-8-14)12-24-18-11-16(21-22-19(18)20)15-9-5-6-10-17(15)23/h2-11,13,23H,12H2,1H3,(H2,20,22) VVYATDRFTFUUGA-UHFFFAOYSA-N 394575 2-(6-amino-5-(2-::US10308614, Example 178 Transcription activator BRG1 [1448-1575] 12.2 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394575&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029410 405264669 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789596 Nc1nnc(cc1OC1CCCCC1)-c1ccccc1O InChI=1S/C16H19N3O2/c17-16-15(21-11-6-2-1-3-7-11)10-13(18-19-16)12-8-4-5-9-14(12)20/h4-5,8-11,20H,1-3,6-7H2,(H2,17,19) YAQNFDWSUJUPDQ-UHFFFAOYSA-N 394576 2-(6-amino-5-::US10308614, Example 179 Transcription activator BRG1 [1448-1575] 45.1 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394576 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394576&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029383 405264670 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789597 Nc1nnc(cc1OC1CCN(Cc2ccccc2)C1)-c1ccccc1O InChI=1S/C21H22N4O2/c22-21-20(12-18(23-24-21)17-8-4-5-9-19(17)26)27-16-10-11-25(14-16)13-15-6-2-1-3-7-15/h1-9,12,16,26H,10-11,13-14H2,(H2,22,24) BTCGLYACXJHVJC-UHFFFAOYSA-N 394577 2-(6-amino-5-((1-::US10308614, Example 180 Transcription activator BRG1 [1448-1575] 43.2 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394577 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394577&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029505 405264671 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789600 Nc1nnc(cc1OC1CCCN(Cc2ccccc2)C1)-c1ccccc1O InChI=1S/C22H24N4O2/c23-22-21(13-19(24-25-22)18-10-4-5-11-20(18)27)28-17-9-6-12-26(15-17)14-16-7-2-1-3-8-16/h1-5,7-8,10-11,13,17,27H,6,9,12,14-15H2,(H2,23,25) FIIMUDFZQPQRSB-UHFFFAOYSA-N 394578 2-(6-amino-5-((1-::US10308614, Example 181 Transcription activator BRG1 [1448-1575] 33.7 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394578&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029516 405264672 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789601 Nc1nnc(cc1OC1CCc2ccccc12)-c1ccccc1O InChI=1S/C19H17N3O2/c20-19-18(24-17-10-9-12-5-1-2-6-13(12)17)11-15(21-22-19)14-7-3-4-8-16(14)23/h1-8,11,17,23H,9-10H2,(H2,20,22) MMFSSTYSGRNBQE-UHFFFAOYSA-N 394579 2-(6-amino-5-((2,3-::US10308614, Example 182 Transcription activator BRG1 [1448-1575] 606 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394579&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029550 405264673 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789602 Nc1nnc(cc1OC1CCCN(C1)c1ccccc1)-c1ccccc1O InChI=1S/C21H22N4O2/c22-21-20(13-18(23-24-21)17-10-4-5-11-19(17)26)27-16-9-6-12-25(14-16)15-7-2-1-3-8-15/h1-5,7-8,10-11,13,16,26H,6,9,12,14H2,(H2,22,24) JVUKRKGPPRNNRG-UHFFFAOYSA-N 394580 2-(6-amino-5-((1-::US10308614, Example 183 Transcription activator BRG1 [1448-1575] 17.2 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394580 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394580&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029517 405264674 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789603 Nc1nnc(cc1OC1CCN(C1)c1ccccc1)-c1ccccc1O InChI=1S/C20H20N4O2/c21-20-19(12-17(22-23-20)16-8-4-5-9-18(16)25)26-15-10-11-24(13-15)14-6-2-1-3-7-14/h1-9,12,15,25H,10-11,13H2,(H2,21,23) PFPBTBLUYMUDBP-UHFFFAOYSA-N 394581 2-(6-amino-5-((1-::US10308614, Example 184 Transcription activator BRG1 [1448-1575] 192 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394581 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394581&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029515 405264675 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789604 Nc1nnc(cc1OC1CCCN(C1)C(=O)c1ccccc1)-c1ccccc1O InChI=1S/C22H22N4O3/c23-21-20(13-18(24-25-21)17-10-4-5-11-19(17)27)29-16-9-6-12-26(14-16)22(28)15-7-2-1-3-8-15/h1-5,7-8,10-11,13,16,27H,6,9,12,14H2,(H2,23,25) FGMBBFOPQBOTSR-UHFFFAOYSA-N 394582 (3-((3-amino-6-(2-::US10308614, Example 185 Transcription activator BRG1 [1448-1575] 641 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394582 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394582&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029446 405264676 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789605 Nc1nnc(cc1-c1ccccc1)-c1ccccc1O InChI=1S/C16H13N3O/c17-16-13(11-6-2-1-3-7-11)10-14(18-19-16)12-8-4-5-9-15(12)20/h1-10,20H,(H2,17,19) SDAWPVIWTVUTCC-UHFFFAOYSA-N 394583 2-(6-amino-5-phenylpyridazin-3-yl)phenol::US10308614, Example 186 Transcription activator BRG1 [1448-1575] 38.7 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394583 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394583&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search GGU 7TAB 137045897 405264677 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789608 Cn1cc(cn1)-c1cc(nnc1N)-c1ccccc1O InChI=1S/C14H13N5O/c1-19-8-9(7-16-19)11-6-12(17-18-14(11)15)10-4-2-3-5-13(10)20/h2-8,20H,1H3,(H2,15,18) JISLSABSHWDDTJ-UHFFFAOYSA-N 394584 2-(6-amino-5-(1-methyl-::US10308614, Example 187 Transcription activator BRG1 [1448-1575] 12.8 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394584 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394584&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029367 405264678 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789611 CC(c1ccccc1)n1cc(cn1)-c1cc(nnc1N)-c1ccccc1O InChI=1S/C21H19N5O/c1-14(15-7-3-2-4-8-15)26-13-16(12-23-26)18-11-19(24-25-21(18)22)17-9-5-6-10-20(17)27/h2-14,27H,1H3,(H2,22,25) GSAKHYJGZSBABY-UHFFFAOYSA-N 394585 2-(6-amino-5-(1-(1-::US10308614, Example 188 Transcription activator BRG1 [1448-1575] 6.60 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394585 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394585&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029401 405264679 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789614 CN(C)Cc1ccc(cc1)-c1cc(nnc1N)-c1ccccc1O InChI=1S/C19H20N4O/c1-23(2)12-13-7-9-14(10-8-13)16-11-17(21-22-19(16)20)15-5-3-4-6-18(15)24/h3-11,24H,12H2,1-2H3,(H2,20,22) COKXUIZUCWUEQS-UHFFFAOYSA-N 394586 2-(6-amino-5-(4-::US10308614, Example 189 Transcription activator BRG1 [1448-1575] 22.2 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394586 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394586&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029365 405264680 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789617 Nc1nnc(cc1C1CC1)-c1ccccc1O InChI=1S/C13H13N3O/c14-13-10(8-5-6-8)7-11(15-16-13)9-3-1-2-4-12(9)17/h1-4,7-8,17H,5-6H2,(H2,14,16) SPQFKAUBHXPELH-UHFFFAOYSA-N 394587 2-(6-amino-5-::US10308614, Example 190 Transcription activator BRG1 [1448-1575] 17.6 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394587 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394587&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029444 405264681 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789618 Cn1cnc(c1)-c1cc(nnc1N)-c1ccccc1O InChI=1S/C14H13N5O/c1-19-7-12(16-8-19)10-6-11(17-18-14(10)15)9-4-2-3-5-13(9)20/h2-8,20H,1H3,(H2,15,18) DGCXLWUXCRWGHQ-UHFFFAOYSA-N 394588 2-(6-amino-5-(1-methyl-::US10308614, Example 191 Transcription activator BRG1 [1448-1575] 29.3 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394588 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394588&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137045967 405264682 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789619 CC(c1ccccc1)n1cnc(c1)-c1cc(nnc1N)-c1ccccc1O InChI=1S/C21H19N5O/c1-14(15-7-3-2-4-8-15)26-12-19(23-13-26)17-11-18(24-25-21(17)22)16-9-5-6-10-20(16)27/h2-14,27H,1H3,(H2,22,25) RQWVMRVGMOGIBX-UHFFFAOYSA-N 394589 2-(6-amino-5-(1-(1-::US10308614, Example 192 Transcription activator BRG1 [1448-1575] 6.30 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394589&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029500 405264683 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789620 Cn1nccc1-c1cc(nnc1N)-c1ccccc1O InChI=1S/C14H13N5O/c1-19-12(6-7-16-19)10-8-11(17-18-14(10)15)9-4-2-3-5-13(9)20/h2-8,20H,1H3,(H2,15,18) FOKZOSXJTVDAJG-UHFFFAOYSA-N 394590 2-(6-amino-5-(1-methyl-::US10308614, Example 193 Transcription activator BRG1 [1448-1575] 1079 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394590 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394590&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029409 405264684 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789621 CC(C(=O)N(C)C)n1cc(cn1)-c1cc(nnc1N)-c1ccccc1O InChI=1S/C18H20N6O2/c1-11(18(26)23(2)3)24-10-12(9-20-24)14-8-15(21-22-17(14)19)13-6-4-5-7-16(13)25/h4-11,25H,1-3H3,(H2,19,22) UBFNRPGSFRMZGQ-UHFFFAOYSA-N 394591 2-(4-(3-amino-6-(2-::US10308614, Example 194 Transcription activator BRG1 [1448-1575] 24.7 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394591 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394591&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029392 405264685 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789622 C[C@H](C(=O)N(C)C)n1cc(cn1)-c1cc(nnc1N)-c1ccccc1O InChI=1S/C18H20N6O2/c1-11(18(26)23(2)3)24-10-12(9-20-24)14-8-15(21-22-17(14)19)13-6-4-5-7-16(13)25/h4-11,25H,1-3H3,(H2,19,22)/t11-/m1/s1 UBFNRPGSFRMZGQ-LLVKDONJSA-N 394592 (2R)-2-[4-[3-amino- 6-(2- hydroxyphenyl) pyridazin-4-yl]pyrazol- 1-yl]-N,N-dimethyl- propanamide::US10308614, Example 195 Transcription activator BRG1 [1448-1575] 21.7 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394592 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394592&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029427 405264686 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789623 C[C@@H](C(=O)N(C)C)n1cc(cn1)-c1cc(nnc1N)-c1ccccc1O InChI=1S/C18H20N6O2/c1-11(18(26)23(2)3)24-10-12(9-20-24)14-8-15(21-22-17(14)19)13-6-4-5-7-16(13)25/h4-11,25H,1-3H3,(H2,19,22)/t11-/m0/s1 UBFNRPGSFRMZGQ-NSHDSACASA-N 394593 (2S)-2-[4-[3-amino- 6-(2- hydroxyphenyl) pyridazin-4-yl]pyrazol- 1-yl]-N,N-dimethyl- propanamide::US10308614, Example 196 Transcription activator BRG1 [1448-1575] 24.7 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394593 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394593&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029428 405264687 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789624 CC(C(=O)N(C)C)n1cnc(c1)-c1cc(nnc1N)-c1ccccc1O InChI=1S/C18H20N6O2/c1-11(18(26)23(2)3)24-9-15(20-10-24)13-8-14(21-22-17(13)19)12-6-4-5-7-16(12)25/h4-11,25H,1-3H3,(H2,19,22) XGIUNGYDSQQQCX-UHFFFAOYSA-N 394594 2-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-1H-imidazol-1-yl)-N,N-dimethylpropanamide::US10308614, Example 197 Transcription activator BRG1 [1448-1575] 33.9 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394594 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394594&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029445 405264688 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789625 Nc1nnc(cc1[C@@H]1C[C@H]1c1ccccc1)-c1ccccc1O InChI=1S/C19H17N3O/c20-19-16(15-10-14(15)12-6-2-1-3-7-12)11-17(21-22-19)13-8-4-5-9-18(13)23/h1-9,11,14-15,23H,10H2,(H2,20,22)/t14-,15+/m0/s1 SHLMDDDFBPBDMH-LSDHHAIUSA-N 394595 2-(6-amino-5-(trans-2-phenylcyclopropyl)pyridazin-3-yl)phenol::US10308614, Example 198 Transcription activator BRG1 [1448-1575] 12.1 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394595 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394595&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137045918 405264689 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789626 Nc1nnc(cc1Cc1ccccc1)-c1ccccc1O InChI=1S/C17H15N3O/c18-17-13(10-12-6-2-1-3-7-12)11-15(19-20-17)14-8-4-5-9-16(14)21/h1-9,11,21H,10H2,(H2,18,20) IUUNUULQTTZTNG-UHFFFAOYSA-N 394596 2-(6-amino-5-benzylpyridazin-3-yl)phenol::US10308614, Example 199 Transcription activator BRG1 [1448-1575] 995 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394596 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394596&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137045941 405264690 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789627 Nc1nnc(cc1\C=C\Cc1ccccc1)-c1ccccc1O InChI=1S/C19H17N3O/c20-19-15(10-6-9-14-7-2-1-3-8-14)13-17(21-22-19)16-11-4-5-12-18(16)23/h1-8,10-13,23H,9H2,(H2,20,22)/b10-6+ KHQPVCJMHTUNLE-UXBLZVDNSA-N 394597 (E)-2-(6-amino-5-(3-phenylprop-1-en-1-yl)pyridazin-3-yl)phenol::US10308614, Example 200 Transcription activator BRG1 [1448-1575] 31.6 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394597&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137045942 405264691 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789628 Nc1nnc(cc1[C@@H](O)[C@H](O)Cc1ccccc1)-c1ccccc1O InChI=1S/C19H19N3O3/c20-19-14(18(25)17(24)10-12-6-2-1-3-7-12)11-15(21-22-19)13-8-4-5-9-16(13)23/h1-9,11,17-18,23-25H,10H2,(H2,20,22)/t17-,18-/m1/s1 QBCMDHXGPUYPKI-QZTJIDSGSA-N 394598 1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-3-phenylpropane-1,2-diol::US10308614, Example 201 Transcription activator BRG1 [1448-1575] 312 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394598&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029442 405264692 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789629 Nc1ccc(nn1)-c1ccccc1O InChI=1S/C10H9N3O/c11-10-6-5-8(12-13-10)7-3-1-2-4-9(7)14/h1-6,14H,(H2,11,13) AHRNDHTYSONZPP-UHFFFAOYSA-N 394599 2-(6-aminopyridazin-3-yl)phenol::US10308614, Example 203 Transcription activator BRG1 [1448-1575] 335 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394599 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394599&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 136145607 405264693 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789630 CNc1ccc(nn1)-c1ccccc1O InChI=1S/C11H11N3O/c1-12-11-7-6-9(13-14-11)8-4-2-3-5-10(8)15/h2-7,15H,1H3,(H,12,14) UWHKFKASLJRTNP-UHFFFAOYSA-N 394600 2-(6-(methylamino)pyridazin-3-yl)phenol::US10308614, Example 204 Transcription activator BRG1 [1448-1575] 894 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394600 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394600&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 136145557 405264694 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789633 CC(=O)Nc1ccc(nn1)-c1ccccc1O InChI=1S/C12H11N3O2/c1-8(16)13-12-7-6-10(14-15-12)9-4-2-3-5-11(9)17/h2-7,17H,1H3,(H,13,15,16) QIIPAFJJLGMKGH-UHFFFAOYSA-N 394601 N-(6-(2-hydroxyphenyl)pyridazin-3-yl)acetamide::US10308614, Example 205 Transcription activator BRG1 [1448-1575] 1080 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394601 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394601&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137045892 405264695 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789634 Nc1nnc(cc1-c1ccccc1)-c1cccc(F)c1O InChI=1S/C16H12FN3O/c17-13-8-4-7-11(15(13)21)14-9-12(16(18)20-19-14)10-5-2-1-3-6-10/h1-9,21H,(H2,18,20) YIQNHNMFVVDQQU-UHFFFAOYSA-N 394602 2-(6-amino-5-phenylpyridazin-3-yl)-6-fluorophenol::US10308614, Example 206 Transcription activator BRG1 [1448-1575] 98.2 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394602&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137045957 405264696 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789637 CC(C)(O)c1cc(nnc1N)-c1ccccc1O InChI=1S/C13H15N3O2/c1-13(2,18)9-7-10(15-16-12(9)14)8-5-3-4-6-11(8)17/h3-7,17-18H,1-2H3,(H2,14,16) KOCILNCGORUOQP-UHFFFAOYSA-N 394603 2-(6-amino-5-(2-hydroxypropan-2-yl)pyridazin-3-yl)phenol::US10308614, Example 207 Transcription activator BRG1 [1448-1575] 449 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394603 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394603&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137045889 405264697 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789638 Nc1nnc(cc1S(=O)(=O)Cc1ccccc1)-c1ccccc1O InChI=1S/C17H15N3O3S/c18-17-16(24(22,23)11-12-6-2-1-3-7-12)10-14(19-20-17)13-8-4-5-9-15(13)21/h1-10,21H,11H2,(H2,18,20) MDAAKUFKVURBME-UHFFFAOYSA-N 394604 2-(6-amino-5-(benzylsulfonyl)pyridazin-3-yl)phenol::US10308614, Example 208 Transcription activator BRG1 [1448-1575] 995 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394604 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394604&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137045906 405264698 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789639 Nc1nnc(cc1C1CCCCC1)-c1ccccc1O InChI=1S/C16H19N3O/c17-16-13(11-6-2-1-3-7-11)10-14(18-19-16)12-8-4-5-9-15(12)20/h4-5,8-11,20H,1-3,6-7H2,(H2,17,19) QMIHYQHNCMLKCV-UHFFFAOYSA-N 394605 2-(6-amino-5-cyclohexylpyridazin-3-yl)phenol::US10308614, Example 209 Transcription activator BRG1 [1448-1575] 14.5 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394605 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394605&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137045919 405264699 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789642 Nc1nnc(cc1C1CCCC1)-c1ccccc1O InChI=1S/C15H17N3O/c16-15-12(10-5-1-2-6-10)9-13(17-18-15)11-7-3-4-8-14(11)19/h3-4,7-10,19H,1-2,5-6H2,(H2,16,18) AKIDLWUESNUXNK-UHFFFAOYSA-N 394606 2-(6-amino-5-::US10308614, Example 210 Transcription activator BRG1 [1448-1575] 23.9 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394606 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394606&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029376 405264700 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789645 CN1CCC(CC1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C16H20N4O/c1-20-8-6-11(7-9-20)13-10-14(18-19-16(13)17)12-4-2-3-5-15(12)21/h2-5,10-11,21H,6-9H2,1H3,(H2,17,19) KOAJRRBIVSCDEV-UHFFFAOYSA-N 394607 2-(6-amino-5-(1-::US10308614, Example 211 Transcription activator BRG1 [1448-1575] 183 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394607 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394607&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029491 405264701 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789646 CC(C)(C)OC(=O)N1CCC(C1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C19H24N4O3/c1-19(2,3)26-18(25)23-9-8-12(11-23)14-10-15(21-22-17(14)20)13-6-4-5-7-16(13)24/h4-7,10,12,24H,8-9,11H2,1-3H3,(H2,20,22) RGVZKGWVSZWGFB-UHFFFAOYSA-N 394608 US10308614, Example 212::tert-butyl 3-(3-amino-6- Transcription activator BRG1 [1448-1575] 69.4 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394608&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137045968 405264702 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789647 Nc1nnc(cc1C1CCOCC1)-c1ccccc1O InChI=1S/C15H17N3O2/c16-15-12(10-5-7-20-8-6-10)9-13(17-18-15)11-3-1-2-4-14(11)19/h1-4,9-10,19H,5-8H2,(H2,16,18) SJLCWPAOOFQJLQ-UHFFFAOYSA-N 394609 2-(6-amino-5-::US10308614, Example 213 Transcription activator BRG1 [1448-1575] 61.1 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394609 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394609&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029389 405264703 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789648 Nc1nnc(cc1C1CCCN(Cc2ccccc2)C1)-c1ccccc1O InChI=1S/C22H24N4O/c23-22-19(13-20(24-25-22)18-10-4-5-11-21(18)27)17-9-6-12-26(15-17)14-16-7-2-1-3-8-16/h1-5,7-8,10-11,13,17,27H,6,9,12,14-15H2,(H2,23,25) OPKCJVOABAVQBR-UHFFFAOYSA-N 394610 2-(6-amino-5-(1-::US10308614, Example 214 Transcription activator BRG1 [1448-1575] 112 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394610 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394610&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029489 405264704 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789649 Nc1nnc(cc1C1CCNC1)-c1ccccc1O InChI=1S/C14H16N4O/c15-14-11(9-5-6-16-8-9)7-12(17-18-14)10-3-1-2-4-13(10)19/h1-4,7,9,16,19H,5-6,8H2,(H2,15,18) ZEOGDHRRXPLZIK-UHFFFAOYSA-N 394611 2-(6-amino-5-(pyrrolidin-3-yl)pyridazin-3-yl)phenol Hydrochloride::US10308614, Example 215 Transcription activator BRG1 [1448-1575] 743 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394611 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394611&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137045888 405264705 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789650 CN1CCC(C1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C15H18N4O/c1-19-7-6-10(9-19)12-8-13(17-18-15(12)16)11-4-2-3-5-14(11)20/h2-5,8,10,20H,6-7,9H2,1H3,(H2,16,18) IXWMVTOMWKRMMM-UHFFFAOYSA-N 394612 2-(6-amino-5-(1-methylpyrrolidin-3-yl)pyridazin-3-yl)phenol 2,2,2-trifluoroacetate::US10308614, Example 216 Transcription activator BRG1 [1448-1575] 765 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394612 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394612&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029440 405264706 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789651 Nc1nnc(cc1C1CCN(C1)S(=O)(=O)c1ccccc1)-c1ccccc1O InChI=1S/C20H20N4O3S/c21-20-17(12-18(22-23-20)16-8-4-5-9-19(16)25)14-10-11-24(13-14)28(26,27)15-6-2-1-3-7-15/h1-9,12,14,25H,10-11,13H2,(H2,21,23) LTOWBWFTKOUSOO-UHFFFAOYSA-N 394613 2-(6-amino-5-(1-(phenylsulfonyl)pyrrolidin-3-yl)pyridazin-3-yl)phenol::US10308614, Example 217 Transcription activator BRG1 [1448-1575] 412 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394613 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394613&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137045922 405264707 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789654 Nc1nnc(cc1C1CCN(Cc2ccccc2)CC1)-c1ccccc1O InChI=1S/C22H24N4O/c23-22-19(14-20(24-25-22)18-8-4-5-9-21(18)27)17-10-12-26(13-11-17)15-16-6-2-1-3-7-16/h1-9,14,17,27H,10-13,15H2,(H2,23,25) NSAUQIQMBFHQRE-UHFFFAOYSA-N 394614 2-(6-amino-5-(1-benzylpiperidin-4-yl)pyridazin-3-yl)phenol::US10308614, Example 218 Transcription activator BRG1 [1448-1575] 55.3 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394614 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394614&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029557 405264708 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789657 Cc1ccc(cc1)S(=O)(=O)N1CCC(CC1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C22H24N4O3S/c1-15-6-8-17(9-7-15)30(28,29)26-12-10-16(11-13-26)19-14-20(24-25-22(19)23)18-4-2-3-5-21(18)27/h2-9,14,16,27H,10-13H2,1H3,(H2,23,25) UHXYBMZWTTTXRJ-UHFFFAOYSA-N 394615 2-(6-amino-5-(1-tosylpiperidin-4-yl)pyridazin-3-yl)phenol::US10308614, Example 219 Transcription activator BRG1 [1448-1575] 360 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394615 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394615&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137045970 405264709 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789658 CC(=O)N1[C@H]2CC[C@@H]1C[C@H](C2)c1cc(nnc1N)-c1ccccc1O InChI=1S/C19H22N4O2/c1-11(24)23-13-6-7-14(23)9-12(8-13)16-10-17(21-22-19(16)20)15-4-2-3-5-18(15)25/h2-5,10,12-14,25H,6-9H2,1H3,(H2,20,22)/t12-,13-,14+ VGJPIZHUKBXSHI-ZSOGYDGISA-N 394616 Cis- and trans-1-(3-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-8-azabicyclo[3.2.1]octan-8-yl)ethanone::US10308614, Example 220 Transcription activator BRG1 [1448-1575] 109 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394616 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394616&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137277893 405264710 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789659 CC(=O)N1[C@H]2CC[C@@H]1C[C@@H](C2)c1cc(nnc1N)-c1ccccc1O InChI=1S/C19H22N4O2/c1-11(24)23-13-6-7-14(23)9-12(8-13)16-10-17(21-22-19(16)20)15-4-2-3-5-18(15)25/h2-5,10,12-14,25H,6-9H2,1H3,(H2,20,22)/t12-,13+,14- VGJPIZHUKBXSHI-BTTYYORXSA-N 394617 Cis- and trans-1-(3-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-8-azabicyclo[3.2.1]octan-8-yl)ethanone::US10308614, Example 221 Transcription activator BRG1 [1448-1575] 89.8 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394617&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137277893 405264711 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789660 Cc1ccc(cc1)S(=O)(=O)N1CCC(=CC1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C22H22N4O3S/c1-15-6-8-17(9-7-15)30(28,29)26-12-10-16(11-13-26)19-14-20(24-25-22(19)23)18-4-2-3-5-21(18)27/h2-10,14,27H,11-13H2,1H3,(H2,23,25) VHSFKTYVWKCXSM-UHFFFAOYSA-N 394618 2-(6-amino-5-(1-tosyl-1,2,3,6-tetrahydropyridin-4-yl)pyridazin-3-yl)phenol::US10308614, Example 222 Transcription activator BRG1 [1448-1575] 88.9 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394618 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394618&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137045974 405264712 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789661 Nc1nnc(cc1C1=CCN(Cc2ccccc2)CC1)-c1ccccc1O InChI=1S/C22H22N4O/c23-22-19(14-20(24-25-22)18-8-4-5-9-21(18)27)17-10-12-26(13-11-17)15-16-6-2-1-3-7-16/h1-10,14,27H,11-13,15H2,(H2,23,25) NXPRAEIFHKRCER-UHFFFAOYSA-N 394619 2-(6-amino-5-(1-benzyl-1,2,3,6-tetrahydropyridin-4-yl)pyridazin-3-yl)phenol::US10308614, Example 223 Transcription activator BRG1 [1448-1575] 20.5 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394619 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394619&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029397 405264713 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789662 Nc1nnc(cc1C1CCN(CC1)S(=O)(=O)c1ccccc1)-c1ccccc1O InChI=1S/C21H22N4O3S/c22-21-18(14-19(23-24-21)17-8-4-5-9-20(17)26)15-10-12-25(13-11-15)29(27,28)16-6-2-1-3-7-16/h1-9,14-15,26H,10-13H2,(H2,22,24) JJKFPEMDTOUCBF-UHFFFAOYSA-N 394620 2-[6-amino-5-[1- (benzenesulfonyl)-4- piperidyl]pyridazin- 3-yl]phenol::US10308614, Example 224 Transcription activator BRG1 [1448-1575] 60.2 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394620&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029412 405264714 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789663 C[C@H]1CC[C@@H](CC1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C17H21N3O/c1-11-6-8-12(9-7-11)14-10-15(19-20-17(14)18)13-4-2-3-5-16(13)21/h2-5,10-12,21H,6-9H2,1H3,(H2,18,20)/t11-,12- SRFDTKTZWVRQCG-HAQNSBGRSA-N 394621 2-(6-amino-5-((1,4-trans)-4-methylcyclohexyl)pyridazin-3-yl)phenol and Cis-2-(6-amino-5-((1,4-cis-4-methylcyclohexyl)pyridazin-3-yl)phenol::US10308614, Example 225 Transcription activator BRG1 [1448-1575] 19.0 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394621&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029474 405264715 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789664 C[C@H]1CC[C@H](CC1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C17H21N3O/c1-11-6-8-12(9-7-11)14-10-15(19-20-17(14)18)13-4-2-3-5-16(13)21/h2-5,10-12,21H,6-9H2,1H3,(H2,18,20)/t11-,12+ SRFDTKTZWVRQCG-TXEJJXNPSA-N 394622 2-(6-amino-5-((1,4-trans)-4-methylcyclohexyl)pyridazin-3-yl)phenol and Cis-2-(6-amino-5-((1,4-cis-4-methylcyclohexyl)pyridazin-3-yl)phenol::US10308614, Example 226 Transcription activator BRG1 [1448-1575] 20.9 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394622&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029474 405264716 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789665 CC(=O)N1CCC(CC1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C17H20N4O2/c1-11(22)21-8-6-12(7-9-21)14-10-15(19-20-17(14)18)13-4-2-3-5-16(13)23/h2-5,10,12,23H,6-9H2,1H3,(H2,18,20) GWSQERVUKMVBLY-UHFFFAOYSA-N 394623 1-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-1-yl)ethanone::US10308614, Example 227 Transcription activator BRG1 [1448-1575] 84.8 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394623&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137045953 405264717 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789666 CS(=O)(=O)N1CCC(CC1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C16H20N4O3S/c1-24(22,23)20-8-6-11(7-9-20)13-10-14(18-19-16(13)17)12-4-2-3-5-15(12)21/h2-5,10-11,21H,6-9H2,1H3,(H2,17,19) AOXSISKTCWNYJS-UHFFFAOYSA-N 394624 2-(6-amino-5-(1-(methylsulfonyl)piperidin-4-yl)pyridazin-3-yl)phenol::US10308614, Example 228 Transcription activator BRG1 [1448-1575] 53.7 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394624 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394624&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137045958 405264718 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789667 CC(C)(O)C(=O)N1CCC(CC1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C19H24N4O3/c1-19(2,26)18(25)23-9-7-12(8-10-23)14-11-15(21-22-17(14)20)13-5-3-4-6-16(13)24/h3-6,11-12,24,26H,7-10H2,1-2H3,(H2,20,22) KNOMYXUEWDDRJL-UHFFFAOYSA-N 394625 1-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-1-yl)-2-hydroxy-2-methylpropan-1-one::US10308614, Example 229 Transcription activator BRG1 [1448-1575] 43.7 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394625&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029429 405264719 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789668 Nc1nnc(cc1-c1ccccc1)-c1cc(F)ccc1O InChI=1S/C16H12FN3O/c17-11-6-7-15(21)13(8-11)14-9-12(16(18)20-19-14)10-4-2-1-3-5-10/h1-9,21H,(H2,18,20) WKMZPHUADUZHSN-UHFFFAOYSA-N 394626 2-(6-amino-5- phenyl-pyridazin-3- yl)-4-fluoro-phenol::US10308614, Example 230 Transcription activator BRG1 [1448-1575] 54.9 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394626&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029413 405264720 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789669 Nc1nnc(cc1-c1ccccc1)-c1ccc(F)cc1O InChI=1S/C16H12FN3O/c17-11-6-7-12(15(21)8-11)14-9-13(16(18)20-19-14)10-4-2-1-3-5-10/h1-9,21H,(H2,18,20) VIKSFOQOUYWBIH-UHFFFAOYSA-N 394627 2-(6-amino-5-::US10308614, Example 231 Transcription activator BRG1 [1448-1575] 995 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394627 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394627&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029431 405264721 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789670 Nc1nnc(cc1-c1ccccc1)-c1cc(F)cc(F)c1O InChI=1S/C16H11F2N3O/c17-10-6-12(15(22)13(18)7-10)14-8-11(16(19)21-20-14)9-4-2-1-3-5-9/h1-8,22H,(H2,19,21) FRUZJKJAQZMJHP-UHFFFAOYSA-N 394628 2-(6-amino-5-::US10308614, Example 232 Transcription activator BRG1 [1448-1575] 176 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394628 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394628&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029433 405264722 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789671 Nc1nnc(cc1-c1ccccc1)-c1c(O)cccc1F InChI=1S/C16H12FN3O/c17-12-7-4-8-14(21)15(12)13-9-11(16(18)20-19-13)10-5-2-1-3-6-10/h1-9,21H,(H2,18,20) RTGAFPUNFCLWNN-UHFFFAOYSA-N 394629 2-(6-amino-5-phenylpyridazin-3-yl)-3-fluorophenol::US10308614, Example 233 Transcription activator BRG1 [1448-1575] 435 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394629 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394629&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137045915 405264723 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789672 Nc1nnc(cc1C(=O)NCc1ccccc1)-c1ccccc1O InChI=1S/C18H16N4O2/c19-17-14(18(24)20-11-12-6-2-1-3-7-12)10-15(21-22-17)13-8-4-5-9-16(13)23/h1-10,23H,11H2,(H2,19,22)(H,20,24) JIFHOFMTFIXJRU-UHFFFAOYSA-N 394630 3-amino-N-benzyl-6-(2-hydroxyphenyl)pyridazine-4-carboxamide::US10308614, Example 234 Transcription activator BRG1 [1448-1575] 102 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394630 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394630&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137045899 405264724 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789673 Nc1nnc(cc1C(=O)N[C@@H]1C[C@H]1c1ccccc1)-c1ccccc1O InChI=1S/C20H18N4O2/c21-19-15(11-17(23-24-19)13-8-4-5-9-18(13)25)20(26)22-16-10-14(16)12-6-2-1-3-7-12/h1-9,11,14,16,25H,10H2,(H2,21,24)(H,22,26)/t14-,16+/m0/s1 QFWBRPFWXGRAHS-GOEBONIOSA-N 394631 3-amino-6-(2-hydroxyphenyl)-N-(trans-2-phenylcyclopropyl)pyridazine-4-carboxamide::US10308614, Example 235 Transcription activator BRG1 [1448-1575] 214 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394631 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394631&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029452 405264725 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789674 Nc1nnc(cc1C1CCCO1)-c1ccccc1O InChI=1S/C14H15N3O2/c15-14-10(13-6-3-7-19-13)8-11(16-17-14)9-4-1-2-5-12(9)18/h1-2,4-5,8,13,18H,3,6-7H2,(H2,15,17) ZILVHLWAUYDDPX-UHFFFAOYSA-N 394632 (rac)-2-(6-amino-5-(tetrahydrofuran-2-yl)pyridazin-3-yl)phenol::US10308614, Example 236 Transcription activator BRG1 [1448-1575] 76.4 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394632 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394632&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137045880 405264726 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789675 Nc1nnc(cc1C1CCCCO1)-c1ccccc1O InChI=1S/C15H17N3O2/c16-15-11(14-7-3-4-8-20-14)9-12(17-18-15)10-5-1-2-6-13(10)19/h1-2,5-6,9,14,19H,3-4,7-8H2,(H2,16,18) VVLGMLLBFOXMQA-UHFFFAOYSA-N 394633 2-(6-amino-5-::US10308614, Example 237 Transcription activator BRG1 [1448-1575] 76.1 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394633 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394633&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137045965 405264727 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789676 Nc1nnc(cc1[C@@H]1CCCO1)-c1ccccc1O InChI=1S/C14H15N3O2/c15-14-10(13-6-3-7-19-13)8-11(16-17-14)9-4-1-2-5-12(9)18/h1-2,4-5,8,13,18H,3,6-7H2,(H2,15,17)/t13-/m0/s1 ZILVHLWAUYDDPX-ZDUSSCGKSA-N 394634 2-[6-amino-5-[(2S)- tetrahydrofuran-2- yl]pyridazin-3- yl]phenol::US10308614, Example 238 Transcription activator BRG1 [1448-1575] 40.5 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394634 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394634&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029495 405264728 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789677 Nc1nnc(cc1[C@H]1CCCO1)-c1ccccc1O InChI=1S/C14H15N3O2/c15-14-10(13-6-3-7-19-13)8-11(16-17-14)9-4-1-2-5-12(9)18/h1-2,4-5,8,13,18H,3,6-7H2,(H2,15,17)/t13-/m1/s1 ZILVHLWAUYDDPX-CYBMUJFWSA-N 394635 2-[6-amino-5-[(2R)- tetrahydrofuran-2- yl]pyridazin-3- yl]phenol::US10308614, Example 239 Transcription activator BRG1 [1448-1575] 179 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394635 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394635&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029455 405264729 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789678 Nc1nnc(cc1[C@H]1CCCCO1)-c1ccccc1O InChI=1S/C15H17N3O2/c16-15-11(14-7-3-4-8-20-14)9-12(17-18-15)10-5-1-2-6-13(10)19/h1-2,5-6,9,14,19H,3-4,7-8H2,(H2,16,18)/t14-/m1/s1 VVLGMLLBFOXMQA-CQSZACIVSA-N 394636 Enantiomer 1 and enantiomer 2 of 2-(6-amino-5-(tetrahydro-2H-pyran-2-yl)pyridazin-3-yl)phenol::US10308614, Example 240 Transcription activator BRG1 [1448-1575] 64.9 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394636 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394636&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029520 405264730 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789679 Nc1nnc(cc1[C@@H]1CCCCO1)-c1ccccc1O InChI=1S/C15H17N3O2/c16-15-11(14-7-3-4-8-20-14)9-12(17-18-15)10-5-1-2-6-13(10)19/h1-2,5-6,9,14,19H,3-4,7-8H2,(H2,16,18)/t14-/m0/s1 VVLGMLLBFOXMQA-AWEZNQCLSA-N 394637 Enantiomer 1 and enantiomer 2 of 2-(6-amino-5-(tetrahydro-2H-pyran-2-yl)pyridazin-3-yl)phenol::US10308614, Example 241 Transcription activator BRG1 [1448-1575] 119 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394637 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394637&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029456 405264731 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789680 C[C@@H]1CN(C[C@@H](C)O1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C16H20N4O2/c1-10-8-20(9-11(2)22-10)14-7-13(18-19-16(14)17)12-5-3-4-6-15(12)21/h3-7,10-11,21H,8-9H2,1-2H3,(H2,17,19)/t10-,11-/m1/s1 LTQBMPHICDLNOB-GHMZBOCLSA-N 394638 2-[6-amino-5- [(2R,6R)-2,6- dimethylmorpholin- 4-yl]pyridazin-3- yl]phenol::US10308614, Example 242 Transcription activator BRG1 [1448-1575] 58.9 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394638 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394638&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029504 405264732 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789681 C[C@H]1CN(C[C@@H](C)O1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C16H20N4O2/c1-10-8-20(9-11(2)22-10)14-7-13(18-19-16(14)17)12-5-3-4-6-15(12)21/h3-7,10-11,21H,8-9H2,1-2H3,(H2,17,19)/t10-,11+ LTQBMPHICDLNOB-PHIMTYICSA-N 394639 2-[6-amino-5- [(2S,6R)-2,6- dimethylmorpholin- 4-yl]pyridazin-3- yl]phenol::US10308614, Example 243 Transcription activator BRG1 [1448-1575] 32.4 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394639 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394639&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137045881 405264733 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789682 C[C@H]1CN(C[C@H](C)O1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C16H20N4O2/c1-10-8-20(9-11(2)22-10)14-7-13(18-19-16(14)17)12-5-3-4-6-15(12)21/h3-7,10-11,21H,8-9H2,1-2H3,(H2,17,19)/t10-,11-/m0/s1 LTQBMPHICDLNOB-QWRGUYRKSA-N 394640 2-[6-amino-5- [(2S,6S)-2,6- dimethylmorpholin- 4-yl]pyridazin-3- yl]phenol::US10308614, Example 244 Transcription activator BRG1 [1448-1575] 37.9 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394640 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394640&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029499 405264734 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789683 Nc1nnc(cc1OC1CCCNC1)-c1ccccc1O InChI=1S/C15H18N4O2/c16-15-14(21-10-4-3-7-17-9-10)8-12(18-19-15)11-5-1-2-6-13(11)20/h1-2,5-6,8,10,17,20H,3-4,7,9H2,(H2,16,19) DPDJJPVIGGSPDW-UHFFFAOYSA-N 394641 2-(6-amino-5-(piperidin-3-yloxy)pyridazin-3-yl)phenol::US10308614, Example 245 Transcription activator BRG1 [1448-1575] 281 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394641 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394641&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137045884 405264735 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789684 CN1CCCC(C1)Oc1cc(nnc1N)-c1ccccc1O InChI=1S/C16H20N4O2/c1-20-8-4-5-11(10-20)22-15-9-13(18-19-16(15)17)12-6-2-3-7-14(12)21/h2-3,6-7,9,11,21H,4-5,8,10H2,1H3,(H2,17,19) OPSVQMZPAZYLLI-UHFFFAOYSA-N 394642 2-(6-amino-5-((1-methylpiperidin-3-yl)oxy)pyridazin-3-yl)phenol::US10308614, Example 246 Transcription activator BRG1 [1448-1575] 260 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394642 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394642&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137045949 405264736 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789685 CC(=O)N1CCCC(C1)Oc1cc(nnc1N)-c1ccccc1O InChI=1S/C17H20N4O3/c1-11(22)21-8-4-5-12(10-21)24-16-9-14(19-20-17(16)18)13-6-2-3-7-15(13)23/h2-3,6-7,9,12,23H,4-5,8,10H2,1H3,(H2,18,20) SOYWZOCZSHRLNH-UHFFFAOYSA-N 394643 1-(3-((3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)oxy)piperidin-1-yl)ethanone::US10308614, Example 247 Transcription activator BRG1 [1448-1575] 137 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394643 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394643&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137045920 405264737 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789382 CC(C)(C)OC(=O)N1CCN(CC1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C19H25N5O3/c1-19(2,3)27-18(26)24-10-8-23(9-11-24)15-12-14(21-22-17(15)20)13-6-4-5-7-16(13)25/h4-7,12,25H,8-11H2,1-3H3,(H2,20,22) AQTNUGRRZDRZIA-UHFFFAOYSA-N 394399 US10308614, Example 1::tert-butyl 4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperazine-1-carboxylate Transcription activator BRG1 [1448-1575] 21.4 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394399 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394399&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search QP8 6ZS4 137045929 405264497 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789383 CN1CCCN(CC1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C16H21N5O/c1-20-7-4-8-21(10-9-20)14-11-13(18-19-16(14)17)12-5-2-3-6-15(12)22/h2-3,5-6,11,22H,4,7-10H2,1H3,(H2,17,19) CPIYZERFZWDYSD-UHFFFAOYSA-N 394400 2-(6-amino-5-(4-methyl-::US10308614, Example 2 Transcription activator BRG1 [1448-1575] 296 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394400 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394400&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029364 405264498 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789384 Nc1nnc(cc1N1CCN(Cc2cccnc2)CC1)-c1ccccc1O InChI=1S/C20H22N6O/c21-20-18(12-17(23-24-20)16-5-1-2-6-19(16)27)26-10-8-25(9-11-26)14-15-4-3-7-22-13-15/h1-7,12-13,27H,8-11,14H2,(H2,21,24) JZLOJEOBZZJRHN-UHFFFAOYSA-N 394401 2-(6-amino-5-(4-(pyridin-::US10308614, Example 3 Transcription activator BRG1 [1448-1575] 37.3 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394401 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394401&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029368 405264499 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789387 CC(=O)N1CCN(CC1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C16H19N5O2/c1-11(22)20-6-8-21(9-7-20)14-10-13(18-19-16(14)17)12-4-2-3-5-15(12)23/h2-5,10,23H,6-9H2,1H3,(H2,17,19) SPSLNCYVKLGTKH-UHFFFAOYSA-N 394402 1-(4-(3-amino-6-(2-::US10308614, Example 4 Transcription activator BRG1 [1448-1575] 65.9 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394402 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394402&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029408 405264500 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789390 CN(C)CC1CCN(CC1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C18H25N5O/c1-22(2)12-13-7-9-23(10-8-13)16-11-15(20-21-18(16)19)14-5-3-4-6-17(14)24/h3-6,11,13,24H,7-10,12H2,1-2H3,(H2,19,21) NCSVRIYOFWYLNA-UHFFFAOYSA-N 394403 2-(6-amino-5-(4-((dimethylami-::US10308614, Example 5 Transcription activator BRG1 [1448-1575] 39.5 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394403 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394403&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029396 405264501 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789393 C[C@H]1CCCCN1c1cc(nnc1N)-c1ccccc1O InChI=1S/C16H20N4O/c1-11-6-4-5-9-20(11)14-10-13(18-19-16(14)17)12-7-2-3-8-15(12)21/h2-3,7-8,10-11,21H,4-6,9H2,1H3,(H2,17,19)/t11-/m0/s1 KXXHZDPNIIOTSH-NSHDSACASA-N 394405 (S)-2-(6-amino-5-(2-::US10308614, Example 6 Transcription activator BRG1 [1448-1575] 84.6 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394405 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394405&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029398 405264503 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789394 Nc1nnc(cc1N1CCNCC1)-c1ccccc1O InChI=1S/C14H17N5O/c15-14-12(19-7-5-16-6-8-19)9-11(17-18-14)10-3-1-2-4-13(10)20/h1-4,9,16,20H,5-8H2,(H2,15,18) SZKHGLTYXIDOFH-UHFFFAOYSA-N 394406 2-(6-amino-5-(piperazin-::US10308614, Example 7 Transcription activator BRG1 [1448-1575] 214 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394406 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394406&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137045944 405264504 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789395 Nc1nnc(cc1N1CCCC(C1)Oc1ccccc1)-c1ccccc1O InChI=1S/C21H22N4O2/c22-21-19(13-18(23-24-21)17-10-4-5-11-20(17)26)25-12-6-9-16(14-25)27-15-7-2-1-3-8-15/h1-5,7-8,10-11,13,16,26H,6,9,12,14H2,(H2,22,24) JOLHNCATQIAQLA-UHFFFAOYSA-N 394407 2-(6-amino-5-(3-::US10308614, Example 8 Transcription activator BRG1 [1448-1575] 49.8 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394407 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394407&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search QMT 6ZN6 137029438 405264505 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789396 Nc1nnc(cc1N1C[C@@H]2CN(Cc3ccccc3)C[C@@H]2C1)-c1ccccc1O InChI=1S/C23H25N5O/c24-23-21(10-20(25-26-23)19-8-4-5-9-22(19)29)28-14-17-12-27(13-18(17)15-28)11-16-6-2-1-3-7-16/h1-10,17-18,29H,11-15H2,(H2,24,26)/t17-,18+ HYFYBIOFAMANIC-HDICACEKSA-N 394408 2-(6-amino-5-((3aR,6aS)-5-::US10308614, Example 9 Transcription activator BRG1 [1448-1575] 61.5 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394408 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394408&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029430 405264506 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789399 Nc1nnc(cc1N1CCCC(C1)c1ccccc1)-c1ccccc1O InChI=1S/C21H22N4O/c22-21-19(13-18(23-24-21)17-10-4-5-11-20(17)26)25-12-6-9-16(14-25)15-7-2-1-3-8-15/h1-5,7-8,10-11,13,16,26H,6,9,12,14H2,(H2,22,24) XOWZBUXGUWIUGY-UHFFFAOYSA-N 394409 2-(6-amino-5-(3-::US10308614, Example 10 Transcription activator BRG1 [1448-1575] 53.0 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394409 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394409&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029405 405264507 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789400 Nc1nnc(cc1N1CCN(CC1)S(=O)(=O)c1ccccc1)-c1ccccc1O InChI=1S/C20H21N5O3S/c21-20-18(14-17(22-23-20)16-8-4-5-9-19(16)26)24-10-12-25(13-11-24)29(27,28)15-6-2-1-3-7-15/h1-9,14,26H,10-13H2,(H2,21,23) FVQHHYIEIMWQMW-UHFFFAOYSA-N 394410 2-(6-amino-5-(4-::US10308614, Example 11 Transcription activator BRG1 [1448-1575] 61.2 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394410 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394410&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029432 405264508 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789401 Nc1nnc(cc1N1CCN(Cc2ccccc2)CC1)-c1ccccc1O InChI=1S/C21H23N5O/c22-21-19(14-18(23-24-21)17-8-4-5-9-20(17)27)26-12-10-25(11-13-26)15-16-6-2-1-3-7-16/h1-9,14,27H,10-13,15H2,(H2,22,24) DNZFADKRABVBAW-UHFFFAOYSA-N 394411 2-(6-amino-5-(4-::US10308614, Example 12 Transcription activator BRG1 [1448-1575] 61.2 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394411 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394411&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029434 405264509 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789402 Nc1nnc(cc1N1CCN(CC1)c1ccccc1)-c1ccccc1O InChI=1S/C20H21N5O/c21-20-18(14-17(22-23-20)16-8-4-5-9-19(16)26)25-12-10-24(11-13-25)15-6-2-1-3-7-15/h1-9,14,26H,10-13H2,(H2,21,23) SFBPWVKFXLSTLM-UHFFFAOYSA-N 394412 2-(6-amino-5-(4-::US10308614, Example 13 Transcription activator BRG1 [1448-1575] 32.1 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394412 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394412&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029502 405264510 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789403 Nc1nnc(cc1N1CCN(Cc2ccccc2)C(=O)C1)-c1ccccc1O InChI=1S/C21H21N5O2/c22-21-18(12-17(23-24-21)16-8-4-5-9-19(16)27)25-10-11-26(20(28)14-25)13-15-6-2-1-3-7-15/h1-9,12,27H,10-11,13-14H2,(H2,22,24) RQXWRQHLJMYXOX-UHFFFAOYSA-N 394413 4-(3-amino-6-(2-::US10308614, Example 14 Transcription activator BRG1 [1448-1575] 73.5 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394413 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394413&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029496 405264511 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789404 CC(N1CCN(CC1)c1cc(nnc1N)-c1ccccc1O)c1ccccc1 InChI=1S/C22H25N5O/c1-16(17-7-3-2-4-8-17)26-11-13-27(14-12-26)20-15-19(24-25-22(20)23)18-9-5-6-10-21(18)28/h2-10,15-16,28H,11-14H2,1H3,(H2,23,25) MBDFNLARUDVNEJ-UHFFFAOYSA-N 394414 2-(6-amino-5-(4-(1-::US10308614, Example 15 Transcription activator BRG1 [1448-1575] 20.9 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394414 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394414&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029510 405264512 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789407 Nc1nnc(cc1N1CC2CCC(C1)N2Cc1ccccc1)-c1ccccc1O InChI=1S/C23H25N5O/c24-23-21(12-20(25-26-23)19-8-4-5-9-22(19)29)27-14-17-10-11-18(15-27)28(17)13-16-6-2-1-3-7-16/h1-9,12,17-18,29H,10-11,13-15H2,(H2,24,26) VZDXUFDLQRAMEG-UHFFFAOYSA-N 394415 2-(6-amino-5-(8-benzyl-3,8-::US10308614, Example 16 Transcription activator BRG1 [1448-1575] 56.3 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394415&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029512 405264513 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789410 Nc1nnc(cc1N1C[C@@H]2C[C@H]1CN2Cc1ccccc1)-c1ccccc1O InChI=1S/C22H23N5O/c23-22-20(11-19(24-25-22)18-8-4-5-9-21(18)28)27-14-16-10-17(27)13-26(16)12-15-6-2-1-3-7-15/h1-9,11,16-17,28H,10,12-14H2,(H2,23,25)/t16-,17-/m0/s1 IIUJOLUWMOQOJA-IRXDYDNUSA-N 394416 2-(6-amino-5-((1S,4S)-5-::US10308614, Example 17::US10308614, Example 56 Transcription activator BRG1 [1448-1575] 147 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394416 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394416&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029439 405264514 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789411 Nc1nnc(cc1N1CCC(CC1)c1ccccc1)-c1ccccc1O InChI=1S/C21H22N4O/c22-21-19(14-18(23-24-21)17-8-4-5-9-20(17)26)25-12-10-16(11-13-25)15-6-2-1-3-7-15/h1-9,14,16,26H,10-13H2,(H2,22,24) JTBGUMSOPXOHEX-UHFFFAOYSA-N 394417 2-(6-amino-5-(4-::US10308614, Example 18 Transcription activator BRG1 [1448-1575] 96.7 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394417 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394417&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029533 405264515 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789412 CN(C)C(=O)C1CCN(CC1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C18H23N5O2/c1-22(2)18(25)12-7-9-23(10-8-12)15-11-14(20-21-17(15)19)13-5-3-4-6-16(13)24/h3-6,11-12,24H,7-10H2,1-2H3,(H2,19,21) XLGIJSDSDDJKBD-UHFFFAOYSA-N 394418 1-(3-amino-6-(2-::US10308614, Example 19 Transcription activator BRG1 [1448-1575] 56.4 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394418&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029528 405264516 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789413 CC(C)(O)C1CCN(CC1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C18H24N4O2/c1-18(2,24)12-7-9-22(10-8-12)15-11-14(20-21-17(15)19)13-5-3-4-6-16(13)23/h3-6,11-12,23-24H,7-10H2,1-2H3,(H2,19,21) GDBMFTJNDQOVIO-UHFFFAOYSA-N 394419 2-(6-amino-5-(4-(2-::US10308614, Example 20 Transcription activator BRG1 [1448-1575] 35.8 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394419 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394419&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029527 405264517 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789414 CN(C)CC1CCCN(C1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C18H25N5O/c1-22(2)11-13-6-5-9-23(12-13)16-10-15(20-21-18(16)19)14-7-3-4-8-17(14)24/h3-4,7-8,10,13,24H,5-6,9,11-12H2,1-2H3,(H2,19,21) CRODHSCPLWHIPA-UHFFFAOYSA-N 394420 2-(6-amino-5-(3-::US10308614, Example 21 Transcription activator BRG1 [1448-1575] 116 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394420 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394420&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029529 405264518 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789415 CC1CN(CCN1Cc1ccccc1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C22H25N5O/c1-16-14-27(12-11-26(16)15-17-7-3-2-4-8-17)20-13-19(24-25-22(20)23)18-9-5-6-10-21(18)28/h2-10,13,16,28H,11-12,14-15H2,1H3,(H2,23,25) ORCVUPADKNRYHX-UHFFFAOYSA-N 394421 2-(6-amino-5-(4-benzyl-::US10308614, Example 22 Transcription activator BRG1 [1448-1575] 42.1 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394421 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394421&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029443 405264519 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789416 Nc1nnc(cc1N1CCNC(C1)C(F)(F)F)-c1ccccc1O InChI=1S/C15H16F3N5O/c16-15(17,18)13-8-23(6-5-20-13)11-7-10(21-22-14(11)19)9-3-1-2-4-12(9)24/h1-4,7,13,20,24H,5-6,8H2,(H2,19,22) CFDJFIHBLGQROE-UHFFFAOYSA-N 394422 2-(6-amino-5-(3-::US10308614, Example 23 Transcription activator BRG1 [1448-1575] 172 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394422 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394422&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029403 405264520 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789417 CNC(=O)CN1CCN(CC1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C17H22N6O2/c1-19-16(25)11-22-6-8-23(9-7-22)14-10-13(20-21-17(14)18)12-4-2-3-5-15(12)24/h2-5,10,24H,6-9,11H2,1H3,(H2,18,21)(H,19,25) JFZYZJCUXXQMOL-UHFFFAOYSA-N 394423 2-(4-(3-amino-6-(2-::US10308614, Example 24 Transcription activator BRG1 [1448-1575] 74.6 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394423 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394423&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029375 405264521 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789418 CN1CCOC2(CCN(CC2)c2cc(nnc2N)-c2ccccc2O)C1 InChI=1S/C19H25N5O2/c1-23-10-11-26-19(13-23)6-8-24(9-7-19)16-12-15(21-22-18(16)20)14-4-2-3-5-17(14)25/h2-5,12,25H,6-11,13H2,1H3,(H2,20,22) NCDKZFMCDUKNIS-UHFFFAOYSA-N 394424 2-(6-amino-5-(4-methyl-::US10308614, Example 25 Transcription activator BRG1 [1448-1575] 17.6 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394424 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394424&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029571 405264522 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789419 CS(=O)(=O)CCN1CCN(CC1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C17H23N5O3S/c1-26(24,25)11-10-21-6-8-22(9-7-21)15-12-14(19-20-17(15)18)13-4-2-3-5-16(13)23/h2-5,12,23H,6-11H2,1H3,(H2,18,20) JPGFNCKJXZMFOE-UHFFFAOYSA-N 394425 2-(6-amino-5-(4-(2-::US10308614, Example 26 Transcription activator BRG1 [1448-1575] 97.8 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394425 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394425&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029568 405264523 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789420 Nc1nnc(cc1N1CCN(CC(F)(F)F)CC1)-c1ccccc1O InChI=1S/C16H18F3N5O/c17-16(18,19)10-23-5-7-24(8-6-23)13-9-12(21-22-15(13)20)11-3-1-2-4-14(11)25/h1-4,9,25H,5-8,10H2,(H2,20,22) IVJLZCMPNXLSNI-UHFFFAOYSA-N 394426 2-(6-amino-5-(4-(2,2,2-::US10308614, Example 27 Transcription activator BRG1 [1448-1575] 75.5 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394426 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394426&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029453 405264524 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789421 Nc1nnc(cc1N1CC[C@@]2(O)CCCC[C@@H]2C1)-c1ccccc1O InChI=1S/C19H24N4O2/c20-18-16(11-15(21-22-18)14-6-1-2-7-17(14)24)23-10-9-19(25)8-4-3-5-13(19)12-23/h1-2,6-7,11,13,24-25H,3-5,8-10,12H2,(H2,20,22)/t13-,19+/m1/s1 CIYLCQZYHHBUOV-YJYMSZOUSA-N 394427 (trans-4a,8a)-2-(3-amino-6-::US10308614, Example 28::US10308614, Example 84 Transcription activator BRG1 [1448-1575] 17.2 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394427 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394427&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029569 405264525 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789422 Nc1nnc(cc1N1CCC2(CNC(=O)C2)CC1)-c1ccccc1O InChI=1S/C18H21N5O2/c19-17-14(9-13(21-22-17)12-3-1-2-4-15(12)24)23-7-5-18(6-8-23)10-16(25)20-11-18/h1-4,9,24H,5-8,10-11H2,(H2,19,22)(H,20,25) GJHSRZQKZYKIBY-UHFFFAOYSA-N 394428 8-(3-amino-6-(2-::US10308614, Example 29 Transcription activator BRG1 [1448-1575] 56.6 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394428 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394428&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029575 405264526 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789423 CC(=O)N1CCCN(CC1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C17H21N5O2/c1-12(23)21-7-4-8-22(10-9-21)15-11-14(19-20-17(15)18)13-5-2-3-6-16(13)24/h2-3,5-6,11,24H,4,7-10H2,1H3,(H2,18,20) HHIPVOVYFQLVJA-UHFFFAOYSA-N 394429 1-(4-(3-amino-6-(2-::US10308614, Example 30 Transcription activator BRG1 [1448-1575] 112 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394429 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394429&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029566 405264527 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789424 CN(C)CC1(O)CCN(CC1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C18H25N5O2/c1-22(2)12-18(25)7-9-23(10-8-18)15-11-14(20-21-17(15)19)13-5-3-4-6-16(13)24/h3-6,11,24-25H,7-10,12H2,1-2H3,(H2,19,21) XACQJOCMBVIQQO-UHFFFAOYSA-N 394430 1-(3-amino-6-(2-::US10308614, Example 31 Transcription activator BRG1 [1448-1575] 20.8 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394430 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394430&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029526 405264528 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789425 CC(C1CCN(CC1)c1cc(nnc1N)-c1ccccc1O)N1CCOCC1 InChI=1S/C21H29N5O2/c1-15(25-10-12-28-13-11-25)16-6-8-26(9-7-16)19-14-18(23-24-21(19)22)17-4-2-3-5-20(17)27/h2-5,14-16,27H,6-13H2,1H3,(H2,22,24) AYCPAAWTIQWPFF-UHFFFAOYSA-N 394431 2-(6-amino-5-(4-(1-::US10308614, Example 32 Transcription activator BRG1 [1448-1575] 30.9 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394431 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394431&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137045938 405264529 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789426 CC1CN(CC(C)O1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C16H20N4O2/c1-10-8-20(9-11(2)22-10)14-7-13(18-19-16(14)17)12-5-3-4-6-15(12)21/h3-7,10-11,21H,8-9H2,1-2H3,(H2,17,19) LTQBMPHICDLNOB-UHFFFAOYSA-N 394432 2-(6-amino-5-(2,6-::US10308614, Example 33 Transcription activator BRG1 [1448-1575] 72.1 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394432&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029414 405264530 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789429 CN(Cc1ccccc1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C18H18N4O/c1-22(12-13-7-3-2-4-8-13)16-11-15(20-21-18(16)19)14-9-5-6-10-17(14)23/h2-11,23H,12H2,1H3,(H2,19,21) YXPUHTDIELKZQV-UHFFFAOYSA-N 394433 2-(6-amino-5-::US10308614, Example 34 Transcription activator BRG1 [1448-1575] 72.0 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394433 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394433&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029388 405264531 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789430 Nc1nnc(cc1N1CCCC1)-c1ccccc1O InChI=1S/C14H16N4O/c15-14-12(18-7-3-4-8-18)9-11(16-17-14)10-5-1-2-6-13(10)19/h1-2,5-6,9,19H,3-4,7-8H2,(H2,15,17) TWJZDPRYXHWSDF-UHFFFAOYSA-N 394434 2-(6-amino-5-(pyrrolidin-::US10308614, Example 35 Transcription activator BRG1 [1448-1575] 64.4 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394434 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394434&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029371 405264532 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789431 CN(CCc1ccccc1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C19H20N4O/c1-23(12-11-14-7-3-2-4-8-14)17-13-16(21-22-19(17)20)15-9-5-6-10-18(15)24/h2-10,13,24H,11-12H2,1H3,(H2,20,22) HSNXUILYEWYOAX-UHFFFAOYSA-N 394435 2-(6-amino-5-::US10308614, Example 36 Transcription activator BRG1 [1448-1575] 96.2 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394435 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394435&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029372 405264533 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789432 CC1CN(CC(C)N1Cc1ccccc1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C23H27N5O/c1-16-13-27(14-17(2)28(16)15-18-8-4-3-5-9-18)21-12-20(25-26-23(21)24)19-10-6-7-11-22(19)29/h3-12,16-17,29H,13-15H2,1-2H3,(H2,24,26) IYEFXJIOVKGYQQ-UHFFFAOYSA-N 394436 2-(6-amino-5-(4-benzyl-::US10308614, Example 37 Transcription activator BRG1 [1448-1575] 102 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394436 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394436&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029387 405264534 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789433 Nc1nnc(cc1N1CCC(O)C1)-c1ccccc1O InChI=1S/C14H16N4O2/c15-14-12(18-6-5-9(19)8-18)7-11(16-17-14)10-3-1-2-4-13(10)20/h1-4,7,9,19-20H,5-6,8H2,(H2,15,17) PMLWCZVOLOSMSR-UHFFFAOYSA-N 394437 1-(3-amino-6-(2-::US10308614, Example 38 Transcription activator BRG1 [1448-1575] 92.1 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394437 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394437&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029436 405264535 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789434 Nc1nnc(cc1N1CCC(O)(Cc2ccccc2)C1)-c1ccccc1O InChI=1S/C21H22N4O2/c22-20-18(12-17(23-24-20)16-8-4-5-9-19(16)26)25-11-10-21(27,14-25)13-15-6-2-1-3-7-15/h1-9,12,26-27H,10-11,13-14H2,(H2,22,24) PUFJFFYEGHZHOR-UHFFFAOYSA-N 394438 1-[3-amino-6-(2- hydroxyphenyl) pyridazin-4-yl]-3- benzyl-pyrrolidin-3- ol::US10308614, Example 39 Transcription activator BRG1 [1448-1575] 113 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394438 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394438&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029541 405264536 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789435 COC1(Cc2ccccc2)CCN(C1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C22H24N4O2/c1-28-22(14-16-7-3-2-4-8-16)11-12-26(15-22)19-13-18(24-25-21(19)23)17-9-5-6-10-20(17)27/h2-10,13,27H,11-12,14-15H2,1H3,(H2,23,25) IBBZKFWTJYRTOK-UHFFFAOYSA-N 394439 2-(6-amino-5-(3-benzyl-::US10308614, Example 40 Transcription activator BRG1 [1448-1575] 79.4 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394439 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394439&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029476 405264537 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789436 Nc1nnc(cc1N1CC2CC1CN2c1ccccn1)-c1ccccc1O InChI=1S/C20H20N6O/c21-20-17(10-16(23-24-20)15-5-1-2-6-18(15)27)25-11-14-9-13(25)12-26(14)19-7-3-4-8-22-19/h1-8,10,13-14,27H,9,11-12H2,(H2,21,24) MTXWDADYKYPVEZ-UHFFFAOYSA-N 394440 2-(6-amino-5-(5-(pyridin-::US10308614, Example 41 Transcription activator BRG1 [1448-1575] 28.2 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394440 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394440&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029472 405264538 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789437 Nc1nnc(cc1N1CCC(O)(CC1)c1ccccc1)-c1ccccc1O InChI=1S/C21H22N4O2/c22-20-18(14-17(23-24-20)16-8-4-5-9-19(16)26)25-12-10-21(27,11-13-25)15-6-2-1-3-7-15/h1-9,14,26-27H,10-13H2,(H2,22,24) IVYOGNVVLLPKCP-UHFFFAOYSA-N 394441 1-(3-amino-6-(2-::US10308614, Example 42 Transcription activator BRG1 [1448-1575] 11.3 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394441&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029465 405264539 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789438 Nc1nnc(cc1N1CC2CCC(C1)N2c1cncnc1)-c1ccccc1O InChI=1S/C20H21N7O/c21-20-18(7-17(24-25-20)16-3-1-2-4-19(16)28)26-10-13-5-6-14(11-26)27(13)15-8-22-12-23-9-15/h1-4,7-9,12-14,28H,5-6,10-11H2,(H2,21,25) GXPCAKOAKFRARN-UHFFFAOYSA-N 394442 2-(6-amino-5-(8-::US10308614, Example 43 Transcription activator BRG1 [1448-1575] 19.3 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394442 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394442&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029407 405264540 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789439 CC1CN(CCC1(O)c1ccccc1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C22H24N4O2/c1-15-14-26(12-11-22(15,28)16-7-3-2-4-8-16)19-13-18(24-25-21(19)23)17-9-5-6-10-20(17)27/h2-10,13,15,27-28H,11-12,14H2,1H3,(H2,23,25) XHYMWPSHAIRZTF-UHFFFAOYSA-N 394443 1-(3-amino-6-(2-::US10308614, Example 44 Transcription activator BRG1 [1448-1575] 25.3 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394443&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029478 405264541 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789440 Nc1nnc(cc1N1CCOCC1)-c1ccccc1O InChI=1S/C14H16N4O2/c15-14-12(18-5-7-20-8-6-18)9-11(16-17-14)10-3-1-2-4-13(10)19/h1-4,9,19H,5-8H2,(H2,15,17) JEKZPGPLMPQKGR-UHFFFAOYSA-N 394444 2-(6-amino-5-::US10308614, Example 45 Transcription activator BRG1 [1448-1575] 101 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394444 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394444&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029366 405264542 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789443 Nc1nnc(cc1N1CCS(=O)(=O)CC1)-c1ccccc1O InChI=1S/C14H16N4O3S/c15-14-12(18-5-7-22(20,21)8-6-18)9-11(16-17-14)10-3-1-2-4-13(10)19/h1-4,9,19H,5-8H2,(H2,15,17) CCWSUPMFCNTFCL-UHFFFAOYSA-N 394445 4-(3-amino-6-(2-::US10308614, Example 46 Transcription activator BRG1 [1448-1575] 414 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394445&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029464 405264543 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789444 Nc1nnc(cc1N1CC2CCC(C1)N2c1ccnc(F)c1)-c1ccccc1O InChI=1S/C21H21FN6O/c22-20-9-13(7-8-24-20)28-14-5-6-15(28)12-27(11-14)18-10-17(25-26-21(18)23)16-3-1-2-4-19(16)29/h1-4,7-10,14-15,29H,5-6,11-12H2,(H2,23,26) OAIVMVFTRBSYKO-UHFFFAOYSA-N 394446 2-(6-amino-5-(8-(2-::US10308614, Example 47 Transcription activator BRG1 [1448-1575] 4.50 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394446&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029540 405264544 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789445 Cn1cc(cn1)N1C2CCC1CN(C2)c1cc(nnc1N)-c1ccccc1O InChI=1S/C20H23N7O/c1-25-10-15(9-22-25)27-13-6-7-14(27)12-26(11-13)18-8-17(23-24-20(18)21)16-4-2-3-5-19(16)28/h2-5,8-10,13-14,28H,6-7,11-12H2,1H3,(H2,21,24) CNOUHRLKIGJTLO-UHFFFAOYSA-N 394447 2-(6-amino-5-(8-(1-::US10308614, Example 48 Transcription activator BRG1 [1448-1575] 30.9 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394447&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029539 405264545 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789446 Nc1nnc(cc1N1CCNC(Cc2ccccc2)C1)-c1ccccc1O InChI=1S/C21H23N5O/c22-21-19(13-18(24-25-21)17-8-4-5-9-20(17)27)26-11-10-23-16(14-26)12-15-6-2-1-3-7-15/h1-9,13,16,23,27H,10-12,14H2,(H2,22,25) YFPBNNBSTUNKHG-UHFFFAOYSA-N 394448 2-(6-amino-5-(3-::US10308614, Example 49 Transcription activator BRG1 [1448-1575] 84.8 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394448&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029507 405264546 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789447 Nc1nnc(cc1N1CC2CCC(C1)N2c1cnccn1)-c1ccccc1O InChI=1S/C20H21N7O/c21-20-17(9-16(24-25-20)15-3-1-2-4-18(15)28)26-11-13-5-6-14(12-26)27(13)19-10-22-7-8-23-19/h1-4,7-10,13-14,28H,5-6,11-12H2,(H2,21,25) RPIVAONWRDMOKU-UHFFFAOYSA-N 394449 2-(6-amino-5-(8-::US10308614, Example 50 Transcription activator BRG1 [1448-1575] 10.6 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394449 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394449&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137277883 405264547 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789448 Nc1nnc(cc1N1CC2CCC(C1)N2c1cncc(F)c1)-c1ccccc1O InChI=1S/C21H21FN6O/c22-13-7-16(10-24-9-13)28-14-5-6-15(28)12-27(11-14)19-8-18(25-26-21(19)23)17-3-1-2-4-20(17)29/h1-4,7-10,14-15,29H,5-6,11-12H2,(H2,23,26) OSZNAUSCLHRXHM-UHFFFAOYSA-N 394450 2-(6-amino-5-(8-(5-::US10308614, Example 51 Transcription activator BRG1 [1448-1575] 3.40 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394450 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394450&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137277875 405264548 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789449 Nc1nnc(cc1N1CCc2[nH]ncc2C1)-c1ccccc1O InChI=1S/C16H16N6O/c17-16-14(22-6-5-12-10(9-22)8-18-19-12)7-13(20-21-16)11-3-1-2-4-15(11)23/h1-4,7-8,23H,5-6,9H2,(H2,17,21)(H,18,19) LDDRTOWHJKNXAL-UHFFFAOYSA-N 394451 2-(6-amino-5-(1,4,6,7-::US10308614, Example 52 Transcription activator BRG1 [1448-1575] 128 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394451 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394451&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029572 405264549 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789450 Nc1nnc(cc1N1CCNC(=O)C1)-c1ccccc1O InChI=1S/C14H15N5O2/c15-14-11(19-6-5-16-13(21)8-19)7-10(17-18-14)9-3-1-2-4-12(9)20/h1-4,7,20H,5-6,8H2,(H2,15,18)(H,16,21) AVYUFHZTDWPSDQ-UHFFFAOYSA-N 394452 4-(3-amino-6-(2-::US10308614, Example 53 Transcription activator BRG1 [1448-1575] 316 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394452 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394452&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029370 405264550 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789451 Nc1nnc(cc1N1CCCC(O)C1)-c1ccccc1O InChI=1S/C15H18N4O2/c16-15-13(19-7-3-4-10(20)9-19)8-12(17-18-15)11-5-1-2-6-14(11)21/h1-2,5-6,8,10,20-21H,3-4,7,9H2,(H2,16,18) VUGYKDOKOLKKRA-UHFFFAOYSA-N 394453 1-(3-amino-6-(2-::US10308614, Example 54 Transcription activator BRG1 [1448-1575] 95.2 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394453 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394453&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029402 405264551 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789452 Nc1nnc(cc1N1CCC(C1)c1ccccc1)-c1ccccc1O InChI=1S/C20H20N4O/c21-20-18(12-17(22-23-20)16-8-4-5-9-19(16)25)24-11-10-15(13-24)14-6-2-1-3-7-14/h1-9,12,15,25H,10-11,13H2,(H2,21,23) RGDLBOJLTCPVJL-UHFFFAOYSA-N 394454 2-(6-amino-5-(3-::US10308614, Example 55 Transcription activator BRG1 [1448-1575] 122 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394454 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394454&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029381 405264552 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789453 Nc1nnc(cc1N1C[C@@H]2C[C@H]1CN2Cc1ccccc1)-c1ccccc1O InChI=1S/C22H23N5O/c23-22-20(11-19(24-25-22)18-8-4-5-9-21(18)28)27-14-16-10-17(27)13-26(16)12-15-6-2-1-3-7-15/h1-9,11,16-17,28H,10,12-14H2,(H2,23,25)/t16-,17-/m0/s1 IIUJOLUWMOQOJA-IRXDYDNUSA-N 394416 2-(6-amino-5-((1S,4S)-5-::US10308614, Example 17::US10308614, Example 56 Transcription activator BRG1 [1448-1575] 180 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394416 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394416&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029439 405264514 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789454 Nc1nnc(cc1N1CC(C1)Oc1ccccc1)-c1ccccc1O InChI=1S/C19H18N4O2/c20-19-17(10-16(21-22-19)15-8-4-5-9-18(15)24)23-11-14(12-23)25-13-6-2-1-3-7-13/h1-10,14,24H,11-12H2,(H2,20,22) SFMYKATXFFQSND-UHFFFAOYSA-N 394456 2-(6-amino-5-(3-::US10308614, Example 57 Transcription activator BRG1 [1448-1575] 17.7 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394456 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394456&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029437 405264553 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789457 Nc1nnc(cc1N1CC(C1)OCc1ccccc1)-c1ccccc1O InChI=1S/C20H20N4O2/c21-20-18(10-17(22-23-20)16-8-4-5-9-19(16)25)24-11-15(12-24)26-13-14-6-2-1-3-7-14/h1-10,15,25H,11-13H2,(H2,21,23) QBDKXWFFCGQUDN-UHFFFAOYSA-N 394457 2-(6-amino-5-(3-::US10308614, Example 58 Transcription activator BRG1 [1448-1575] 25.2 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394457 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394457&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029553 405264554 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789458 Nc1nnc(cc1N1CCCC(O)(C1)c1ccccc1)-c1ccccc1O InChI=1S/C21H22N4O2/c22-20-18(13-17(23-24-20)16-9-4-5-10-19(16)26)25-12-6-11-21(27,14-25)15-7-2-1-3-8-15/h1-5,7-10,13,26-27H,6,11-12,14H2,(H2,22,24) USPHRPHJTLQLSB-UHFFFAOYSA-N 394458 1-(3-amino-6-(2-::US10308614, Example 59 Transcription activator BRG1 [1448-1575] 15.8 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394458&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029511 405264555 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789459 C[C@@H](C1CCN(CC1)c1cc(nnc1N)-c1ccccc1O)N(C)C InChI=1S/C19H27N5O/c1-13(23(2)3)14-8-10-24(11-9-14)17-12-16(21-22-19(17)20)15-6-4-5-7-18(15)25/h4-7,12-14,25H,8-11H2,1-3H3,(H2,20,22)/t13-/m0/s1 KQLSBMOKSUGCRT-ZDUSSCGKSA-N 394459 (S)-2-(6-amino-5-(4-(1-::US10308614, Example 60 Transcription activator BRG1 [1448-1575] 24.7 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394459&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029477 405264556 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789460 Nc1nnc(cc1N1CCN(CC1)C(=O)c1ccccc1)-c1ccccc1O InChI=1S/C21H21N5O2/c22-20-18(14-17(23-24-20)16-8-4-5-9-19(16)27)25-10-12-26(13-11-25)21(28)15-6-2-1-3-7-15/h1-9,14,27H,10-13H2,(H2,22,24) WYJWNCXWBMFJNU-UHFFFAOYSA-N 394460 (4-(3-amino-6-(2-::US10308614, Example 61 Transcription activator BRG1 [1448-1575] 34.8 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394460 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394460&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029469 405264557 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789461 CC1CN(CCN1C(=O)c1ccccc1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C22H23N5O2/c1-15-14-26(11-12-27(15)22(29)16-7-3-2-4-8-16)19-13-18(24-25-21(19)23)17-9-5-6-10-20(17)28/h2-10,13,15,28H,11-12,14H2,1H3,(H2,23,25) FEPZCELQVIKKCX-UHFFFAOYSA-N 394461 (4-(3-amino-6-(2-::US10308614, Example 62 Transcription activator BRG1 [1448-1575] 11.7 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394461 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394461&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029454 405264558 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789462 Nc1nnc(cc1N1CC2CCC(C1)N2c1ccccc1)-c1ccccc1O InChI=1S/C22H23N5O/c23-22-20(12-19(24-25-22)18-8-4-5-9-21(18)28)26-13-16-10-11-17(14-26)27(16)15-6-2-1-3-7-15/h1-9,12,16-17,28H,10-11,13-14H2,(H2,23,25) HRUFTLXIFIAYKI-UHFFFAOYSA-N 394462 2-(6-amino-5-(8-phenyl-3,8-::US10308614, Example 63 Transcription activator BRG1 [1448-1575] 4.30 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394462 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394462&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029450 405264559 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789463 Nc1nnc(cc1N1CCN(C(=O)C1)c1ccccc1)-c1ccccc1O InChI=1S/C20H19N5O2/c21-20-17(12-16(22-23-20)15-8-4-5-9-18(15)26)24-10-11-25(19(27)13-24)14-6-2-1-3-7-14/h1-9,12,26H,10-11,13H2,(H2,21,23) SETATQZCDJCTKO-UHFFFAOYSA-N 394463 4-(3-amino-6-(2-::US10308614, Example 64 Transcription activator BRG1 [1448-1575] 208 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394463 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394463&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029448 405264560 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789464 C[C@H](C1CCN(CC1)c1cc(nnc1N)-c1ccccc1O)N(C)C InChI=1S/C19H27N5O/c1-13(23(2)3)14-8-10-24(11-9-14)17-12-16(21-22-19(17)20)15-6-4-5-7-18(15)25/h4-7,12-14,25H,8-11H2,1-3H3,(H2,20,22)/t13-/m1/s1 KQLSBMOKSUGCRT-CYBMUJFWSA-N 394464 (R)-2-(6-amino-5-(4-(1-::US10308614, Example 65 Transcription activator BRG1 [1448-1575] 27.6 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394464 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394464&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029494 405264561 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789465 CC(=O)N1C2CCC1CN(C2)c1cc(nnc1N)-c1ccccc1O InChI=1S/C18H21N5O2/c1-11(24)23-12-6-7-13(23)10-22(9-12)16-8-15(20-21-18(16)19)14-4-2-3-5-17(14)25/h2-5,8,12-13,25H,6-7,9-10H2,1H3,(H2,19,21) VOUPBFCKDWMIME-UHFFFAOYSA-N 394465 1-(3-(3-amino-6-(2-::US10308614, Example 66 Transcription activator BRG1 [1448-1575] 71.3 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394465 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394465&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137277887 405264562 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789466 CS(=O)(=O)N1C2CCC1CN(C2)c1cc(nnc1N)-c1ccccc1O InChI=1S/C17H21N5O3S/c1-26(24,25)22-11-6-7-12(22)10-21(9-11)15-8-14(19-20-17(15)18)13-4-2-3-5-16(13)23/h2-5,8,11-12,23H,6-7,9-10H2,1H3,(H2,18,20) GWSFDSRYBNGUES-UHFFFAOYSA-N 394466 2-(6-amino-5-(8-::US10308614, Example 67 Transcription activator BRG1 [1448-1575] 29.4 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394466 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394466&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137277877 405264563 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789467 Cn1cc(cn1)N1CCN(CC1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C18H21N7O/c1-23-12-13(11-20-23)24-6-8-25(9-7-24)16-10-15(21-22-18(16)19)14-4-2-3-5-17(14)26/h2-5,10-12,26H,6-9H2,1H3,(H2,19,22) DMIIXMVYJWFTHF-UHFFFAOYSA-N 394467 2-(6-amino-5-(4-(1-::US10308614, Example 68 Transcription activator BRG1 [1448-1575] 36.7 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394467 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394467&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029460 405264564 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789468 Nc1nnc(cc1N1CC2CCC(C1)N2c1ccccn1)-c1ccccc1O InChI=1S/C21H22N6O/c22-21-18(11-17(24-25-21)16-5-1-2-6-19(16)28)26-12-14-8-9-15(13-26)27(14)20-7-3-4-10-23-20/h1-7,10-11,14-15,28H,8-9,12-13H2,(H2,22,25) ZJBIXQRGOHVABT-UHFFFAOYSA-N 394468 2-(6-amino-5-(8-::US10308614, Example 69 Transcription activator BRG1 [1448-1575] 3.90 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394468 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394468&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029534 405264565 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789469 Nc1nnc(cc1N1CC2CCC(C1)N2c1cccnc1)-c1ccccc1O InChI=1S/C21H22N6O/c22-21-19(10-18(24-25-21)17-5-1-2-6-20(17)28)26-12-15-7-8-16(13-26)27(15)14-4-3-9-23-11-14/h1-6,9-11,15-16,28H,7-8,12-13H2,(H2,22,25) LONXFOAWXBIHFI-UHFFFAOYSA-N 394469 2-(6-amino-5-(8-(pyridin-::US10308614, Example 70 Transcription activator BRG1 [1448-1575] 4.10 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394469 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394469&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029535 405264566 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789470 Nc1nnc(cc1N1CC2CCC(C1)N2c1ncccn1)-c1ccccc1O InChI=1S/C20H21N7O/c21-19-17(10-16(24-25-19)15-4-1-2-5-18(15)28)26-11-13-6-7-14(12-26)27(13)20-22-8-3-9-23-20/h1-5,8-10,13-14,28H,6-7,11-12H2,(H2,21,25) YZEWCUUNICQRAE-UHFFFAOYSA-N 394470 2-(6-amino-5-(8-::US10308614, Example 71 Transcription activator BRG1 [1448-1575] 5.00 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394470 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394470&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029531 405264567 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789471 CC1CN(CCN1c1ccccc1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C21H23N5O/c1-15-14-25(11-12-26(15)16-7-3-2-4-8-16)19-13-18(23-24-21(19)22)17-9-5-6-10-20(17)27/h2-10,13,15,27H,11-12,14H2,1H3,(H2,22,24) YIYLCKJEDKOPIF-UHFFFAOYSA-N 394471 2-(6-amino-5-(3-methyl-::US10308614, Example 72 Transcription activator BRG1 [1448-1575] 39.4 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394471 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394471&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029400 405264568 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789472 NC(=O)C1CCN(CC1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C16H19N5O2/c17-15-13(21-7-5-10(6-8-21)16(18)23)9-12(19-20-15)11-3-1-2-4-14(11)22/h1-4,9-10,22H,5-8H2,(H2,17,20)(H2,18,23) XRSFMRWSXFETJT-UHFFFAOYSA-N 394472 1-(3-amino-6-(2-::US10308614, Example 73 Transcription activator BRG1 [1448-1575] 82.4 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394472 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394472&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029406 405264569 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789473 Nc1nnc(cc1N1C[C@H]2C[C@@H]1CN2c1ccccn1)-c1ccccc1O InChI=1S/C20H20N6O/c21-20-17(10-16(23-24-20)15-5-1-2-6-18(15)27)25-11-14-9-13(25)12-26(14)19-7-3-4-8-22-19/h1-8,10,13-14,27H,9,11-12H2,(H2,21,24)/t13-,14-/m1/s1 MTXWDADYKYPVEZ-ZIAGYGMSSA-N 394473 2-(6-amino-5-((1R,4R)-5-::US10308614, Example 74 Transcription activator BRG1 [1448-1575] 10.6 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394473 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394473&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029377 405264570 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789474 Nc1nnc(cc1N1CC2CCC(C1)N2c1ccc(F)cn1)-c1ccccc1O InChI=1S/C21H21FN6O/c22-13-5-8-20(24-10-13)28-14-6-7-15(28)12-27(11-14)18-9-17(25-26-21(18)23)16-3-1-2-4-19(16)29/h1-5,8-10,14-15,29H,6-7,11-12H2,(H2,23,26) CGTRNPUUCLULDO-UHFFFAOYSA-N 394474 2-(6-amino-5-(8-(5-::US10308614, Example 75 Transcription activator BRG1 [1448-1575] 4.00 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394474&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029374 405264571 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789475 Nc1nnc(cc1N1CC2CCC(C1)N2c1ccc(F)cc1)-c1ccccc1O InChI=1S/C22H22FN5O/c23-14-5-7-15(8-6-14)28-16-9-10-17(28)13-27(12-16)20-11-19(25-26-22(20)24)18-3-1-2-4-21(18)29/h1-8,11,16-17,29H,9-10,12-13H2,(H2,24,26) ROJJVHLDEVEXBP-UHFFFAOYSA-N 394475 2-(6-amino-5-(8-(4-::US10308614, Example 76 Transcription activator BRG1 [1448-1575] 6.70 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394475 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394475&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029391 405264572 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789476 Nc1nnc(cc1N1CC2CCC(C1)N2c1nccs1)-c1ccccc1O InChI=1S/C19H20N6OS/c20-18-16(9-15(22-23-18)14-3-1-2-4-17(14)26)24-10-12-5-6-13(11-24)25(12)19-21-7-8-27-19/h1-4,7-9,12-13,26H,5-6,10-11H2,(H2,20,23) ZXXJJIYMURZBRZ-UHFFFAOYSA-N 394476 2-(6-amino-5-(8-(thiazol-::US10308614, Example 77 Transcription activator BRG1 [1448-1575] 6.50 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394476 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394476&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029461 405264573 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789477 Nc1nnc(cc1N1CCC2(CC1)C(=O)Nc1ccccc21)-c1ccccc1O InChI=1S/C22H21N5O2/c23-20-18(13-17(25-26-20)14-5-1-4-8-19(14)28)27-11-9-22(10-12-27)15-6-2-3-7-16(15)24-21(22)29/h1-8,13,28H,9-12H2,(H2,23,26)(H,24,29) UKFOLEWHUJWKCX-UHFFFAOYSA-N 394478 1'-(3-amino-6-(2-::US10308614, Example 78 Transcription activator BRG1 [1448-1575] 75.8 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394478 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394478&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029573 405264575 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789478 CNC(=O)CN1C2CCC1CN(C2)c1cc(nnc1N)-c1ccccc1O InChI=1S/C19H24N6O2/c1-21-18(27)11-25-12-6-7-13(25)10-24(9-12)16-8-15(22-23-19(16)20)14-4-2-3-5-17(14)26/h2-5,8,12-13,26H,6-7,9-11H2,1H3,(H2,20,23)(H,21,27) GWYHNBSIUWKICR-UHFFFAOYSA-N 394479 2-(3-(3-amino-6-(2-::US10308614, Example 79 Transcription activator BRG1 [1448-1575] 139 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394479&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029485 405264576 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789479 C[C@H](N1CCN(CC1)c1cc(nnc1N)-c1ccccc1O)c1ccccc1 InChI=1S/C22H25N5O/c1-16(17-7-3-2-4-8-17)26-11-13-27(14-12-26)20-15-19(24-25-22(20)23)18-9-5-6-10-21(18)28/h2-10,15-16,28H,11-14H2,1H3,(H2,23,25)/t16-/m0/s1 MBDFNLARUDVNEJ-INIZCTEOSA-N 394480 Enantiomer 1 and Enantiomer 2 of 2-(6-amino-5-(4-(1-phenylethyl)piperazin-1-yl)pyridazin-3-yl)phenol::US10308614, Example 80 Transcription activator BRG1 [1448-1575] 55.7 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394480 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394480&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029479 405264577 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789480 C[C@@H](N1CCN(CC1)c1cc(nnc1N)-c1ccccc1O)c1ccccc1 InChI=1S/C22H25N5O/c1-16(17-7-3-2-4-8-17)26-11-13-27(14-12-26)20-15-19(24-25-22(20)23)18-9-5-6-10-21(18)28/h2-10,15-16,28H,11-14H2,1H3,(H2,23,25)/t16-/m1/s1 MBDFNLARUDVNEJ-MRXNPFEDSA-N 394481 Enantiomer 1 and Enantiomer 2 of 2-(6-amino-5-(4-(1-phenylethyl)piperazin-1-yl)pyridazin-3-yl)phenol::US10308614, Example 81 Transcription activator BRG1 [1448-1575] 19.1 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394481 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394481&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029506 405264578 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789481 C[C@H]1CN(CCN1c1ccccc1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C21H23N5O/c1-15-14-25(11-12-26(15)16-7-3-2-4-8-16)19-13-18(23-24-21(19)22)17-9-5-6-10-20(17)27/h2-10,13,15,27H,11-12,14H2,1H3,(H2,22,24)/t15-/m0/s1 YIYLCKJEDKOPIF-HNNXBMFYSA-N 394482 2-[6-amino-5-[(3S)- 3-methyl-4-phenyl- piperazin-1- yl]pyridazin-3- yl]phenol::US10308614, Example 82 Transcription activator BRG1 [1448-1575] 68.4 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394482 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394482&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029463 405264579 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789482 C[C@@H]1CN(CCN1c1ccccc1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C21H23N5O/c1-15-14-25(11-12-26(15)16-7-3-2-4-8-16)19-13-18(23-24-21(19)22)17-9-5-6-10-20(17)27/h2-10,13,15,27H,11-12,14H2,1H3,(H2,22,24)/t15-/m1/s1 YIYLCKJEDKOPIF-OAHLLOKOSA-N 394483 2-[6-amino-5-[(3R)- 3-methyl-4-phenyl- piperazin-1- yl]pyridazin-3- yl]phenol::US10308614, Example 83 Transcription activator BRG1 [1448-1575] 27.6 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394483&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029467 405264580 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789483 Nc1nnc(cc1N1CC[C@@]2(O)CCCC[C@@H]2C1)-c1ccccc1O InChI=1S/C19H24N4O2/c20-18-16(11-15(21-22-18)14-6-1-2-7-17(14)24)23-10-9-19(25)8-4-3-5-13(19)12-23/h1-2,6-7,11,13,24-25H,3-5,8-10,12H2,(H2,20,22)/t13-,19+/m1/s1 CIYLCQZYHHBUOV-YJYMSZOUSA-N 394427 (trans-4a,8a)-2-(3-amino-6-::US10308614, Example 28::US10308614, Example 84 Transcription activator BRG1 [1448-1575] 8.40 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394427 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394427&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029569 405264525 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789484 Nc1nnc(cc1N1CC[C@]2(O)CCCC[C@@H]2C1)-c1ccccc1O InChI=1S/C19H24N4O2/c20-18-16(11-15(21-22-18)14-6-1-2-7-17(14)24)23-10-9-19(25)8-4-3-5-13(19)12-23/h1-2,6-7,11,13,24-25H,3-5,8-10,12H2,(H2,20,22)/t13-,19-/m1/s1 CIYLCQZYHHBUOV-BFUOFWGJSA-N 394485 Enantiomer 1 and Enantiomer 2 of (trans-4a,8a)-2-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)decahydroisoquinolin-4a-ol::US10308614, Example 85 Transcription activator BRG1 [1448-1575] 11.0 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394485 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394485&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029546 405264581 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789485 C[C@@H](C1CCN(CC1)c1cc(nnc1N)-c1ccccc1O)N1CCOCC1 InChI=1S/C21H29N5O2/c1-15(25-10-12-28-13-11-25)16-6-8-26(9-7-16)19-14-18(23-24-21(19)22)17-4-2-3-5-20(17)27/h2-5,14-16,27H,6-13H2,1H3,(H2,22,24)/t15-/m0/s1 AYCPAAWTIQWPFF-HNNXBMFYSA-N 394486 Enantiomer 1 and enantiomer 2 of 2-(6-amino-5-(4-(1-morpholinoethyl)piperidin-1-yl)pyridazin-3-yl)phenol::US10308614, Example 86 Transcription activator BRG1 [1448-1575] 30.2 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394486 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394486&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029544 405264582 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789486 C[C@H](C1CCN(CC1)c1cc(nnc1N)-c1ccccc1O)N1CCOCC1 InChI=1S/C21H29N5O2/c1-15(25-10-12-28-13-11-25)16-6-8-26(9-7-16)19-14-18(23-24-21(19)22)17-4-2-3-5-20(17)27/h2-5,14-16,27H,6-13H2,1H3,(H2,22,24)/t15-/m1/s1 AYCPAAWTIQWPFF-OAHLLOKOSA-N 394487 Enantiomer 1 and enantiomer 2 of 2-(6-amino-5-(4-(1-morpholinoethyl)piperidin-1-yl)pyridazin-3-yl)phenol::US10308614, Example 87 Transcription activator BRG1 [1448-1575] 41.3 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394487 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394487&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029545 405264583 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789487 Nc1nnc(cc1N1CC2CCC(C1)N2c1ccc(nc1)C(O)=O)-c1ccccc1O InChI=1S/C22H22N6O3/c23-21-19(9-18(25-26-21)16-3-1-2-4-20(16)29)27-11-14-5-6-15(12-27)28(14)13-7-8-17(22(30)31)24-10-13/h1-4,7-10,14-15,29H,5-6,11-12H2,(H2,23,26)(H,30,31) QVZDWYLQYFKHJS-UHFFFAOYSA-N 394488 5-(3-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)picolinic Acid::US10308614, Example 88::US10308614, Example 89 Transcription activator BRG1 [1448-1575] 218 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394488 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394488&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029542 405264584 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789488 Nc1nnc(cc1N1CC2CCC(C1)N2c1ccc(nc1)C(O)=O)-c1ccccc1O InChI=1S/C22H22N6O3/c23-21-19(9-18(25-26-21)16-3-1-2-4-20(16)29)27-11-14-5-6-15(12-27)28(14)13-7-8-17(22(30)31)24-10-13/h1-4,7-10,14-15,29H,5-6,11-12H2,(H2,23,26)(H,30,31) QVZDWYLQYFKHJS-UHFFFAOYSA-N 394488 5-(3-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)picolinic Acid::US10308614, Example 88::US10308614, Example 89 Transcription activator BRG1 [1448-1575] 51.7 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394488 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394488&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029542 405264584 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789489 Nc1nnc(cc1N1CCCCC1)-c1ccccc1O InChI=1S/C15H18N4O/c16-15-13(19-8-4-1-5-9-19)10-12(17-18-15)11-6-2-3-7-14(11)20/h2-3,6-7,10,20H,1,4-5,8-9H2,(H2,16,18) RJVQZTLPHCJXNB-UHFFFAOYSA-N 394490 2-(6-amino-5-(piperidin-1-yl)pyridazin-3-yl)phenol::US10308614, Example 90 Transcription activator BRG1 [1448-1575] 34.0 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394490 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394490&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137045907 405264585 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789492 CN(C)C1CCN(CC1)c1cc(nnc1N)-c1ccccc1O InChI=1S/C17H23N5O/c1-21(2)12-7-9-22(10-8-12)15-11-14(19-20-17(15)18)13-5-3-4-6-16(13)23/h3-6,11-12,23H,7-10H2,1-2H3,(H2,18,20) YOSBJJYYUISYLS-UHFFFAOYSA-N 394491 2-(6-amino-5-(4-::US10308614, Example 91 Transcription activator BRG1 [1448-1575] 92.9 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394491 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394491&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029384 405264586 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789493 C[C@H]1CN(CCN1Cc1nccn1C)c1cc(nnc1N)-c1ccccc1O InChI=1S/C20H25N7O/c1-14-12-27(10-9-26(14)13-19-22-7-8-25(19)2)17-11-16(23-24-20(17)21)15-5-3-4-6-18(15)28/h3-8,11,14,28H,9-10,12-13H2,1-2H3,(H2,21,24)/t14-/m0/s1 ITJYQJZDDATQFB-AWEZNQCLSA-N 394492 (S)-2-(6-amino-5-(3-methyl-4-((1-methyl-1H-imidazol-2-yl)methyl)piperazin-1-yl)pyridazin-3-yl)phenol::US10308614, Example 92 Transcription activator BRG1 [1448-1575] 18.5 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394492 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394492&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137045936 405264587 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3 789494 C[C@@H]1CN(CCN1Cc1nccn1C)c1cc(nnc1N)-c1ccccc1O InChI=1S/C20H25N7O/c1-14-12-27(10-9-26(14)13-19-22-7-8-25(19)2)17-11-16(23-24-20(17)21)15-5-3-4-6-18(15)28/h3-8,11,14,28H,9-10,12-13H2,1-2H3,(H2,21,24)/t14-/m1/s1 ITJYQJZDDATQFB-CQSZACIVSA-N 394493 (R)-2-(6-amino-5- (3-methyl-4-((1- methyl-1H- imidazol-2- yl)methyl)piperazin- 1-yl)pyridazin-3- yl)phenol::US10308614, Example 93 Transcription activator BRG1 [1448-1575] 23.8 US Patent 10.7270/Q26112NJ aid1799025 US10308614 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Genentech Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=394493 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=688&target=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=394493&enzyme=Transcription+activator+BRG1+%5B1448-1575%5D&column=ki&startPg=0&Increment=50&submit=Search 137029458 405264588 1 AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES 2GRC,3UVD,5DKD,5EA1,6HR2,6ZS2,7TAB,8G1Q Transcription activator BRG1 SMCA4_HUMAN P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3