BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 51036191 CC(C)C[C@H](NC(=O)[C@H]1O[C@@H]1C(O)=O)C(=O)NCCCCN=C(N)N InChI=1S/C15H27N5O5/c1-8(2)7-9(20-13(22)10-11(25-10)14(23)24)12(21)18-5-3-4-6-19-15(16)17/h8-11H,3-7H2,1-2H3,(H,18,21)(H,20,22)(H,23,24)(H4,16,17,19)/t9-,10-,11-/m0/s1 LTLYEAJONXGNFG-DCAQKATOSA-N 50157741 CHEMBL374508::E-64::E64 Dipeptidyl peptidase 1 770 ChEMBL 10.1074/jbc.M702615200 10.7270/Q2125TJM 17535802 Methot, N; Rubin, J; Guay, D; Beaulieu, C; Ethier, D; Reddy, TJ; Riendeau, D; Percival, MD Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50157741 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50157741&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 123985 104044625 30270 CHEMBL374508 C00722 ZINC13493525 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500329 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@H]2C[C@@H]1[C@@H]1C[C@H]21)C#N)-c1ccc(nc1)C#N InChI=1S/C23H20FN5O/c24-20-6-12(14-3-4-15(9-25)27-11-14)1-2-13(20)5-16(10-26)28-23(30)22-19-8-21(29-22)18-7-17(18)19/h1-4,6,11,16-19,21-22,29H,5,7-8H2,(H,28,30)/t16-,17+,18-,19+,21-,22-/m0/s1 XEYBRPMUORQYDN-RVEDGADZSA-N 150468 US10238633, Example 142::US8987249, 142::US9713606, 142 Dipeptidyl peptidase 1 63.1 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150468 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150468&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430618 252824719 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500345 COCCN1C(=O)Cc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C27H29FN4O3/c1-35-9-8-32-24-13-17(3-5-19(24)14-25(32)33)16-2-4-18(23(28)12-16)10-22(15-29)31-27(34)26-20-6-7-21(11-20)30-26/h2-5,12-13,20-22,26,30H,6-11,14H2,1H3,(H,31,34)/t20-,21+,22-,26-/m0/s1 UCFPAQYLFQEDGE-MSZDEVHKSA-N 150484 US10238633, Example 158::US8987249, 158::US9713606, 158 Dipeptidyl peptidase 1 1.50 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150484&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430356 252824735 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500450 CS(=O)(=Nc1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1)C1CCOCC1 InChI=1S/C28H33FN4O3S/c1-37(35,25-9-11-36-12-10-25)33-23-4-2-3-18(13-23)19-5-6-20(26(29)16-19)14-24(17-30)32-28(34)27-21-7-8-22(15-21)31-27/h2-6,13,16,21-22,24-25,27,31H,7-12,14-15H2,1H3,(H,32,34)/t21-,22+,24-,27-,37?/m0/s1 OJKBVCYANOMNAF-JOPHUIKPSA-N 150590 US10238633, Example 264::US8987249, 264::US9713606, 264 Dipeptidyl peptidase 1 17.0 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150590 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150590&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430866 252824841 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 271914 Fc1cc(ccc1C#N)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)s1 InChI=1S/C21H19FN4OS/c22-18-8-12(1-2-14(18)10-23)19-6-5-17(28-19)9-16(11-24)26-21(27)20-13-3-4-15(7-13)25-20/h1-2,5-6,8,13,15-16,20,25H,3-4,7,9H2,(H,26,27)/t13-,15+,16-,20-/m0/s1 PKQASKYTZQOSRJ-YEOLMYPVSA-N 138115 US8871783, 1 Dipeptidyl peptidase 1 13.7 6 25.00 C US Patent 10.7270/Q2F18XF1 aid1800734 US8871783 Anderskewitz, R; Grundl, M; Morschhaeuser, G; Oost, T; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138115&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90431047 249814441 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 271915 CS(=O)(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)s1 InChI=1S/C21H23N3O3S2/c1-29(26,27)18-7-3-13(4-8-18)19-9-6-17(28-19)11-16(12-22)24-21(25)20-14-2-5-15(10-14)23-20/h3-4,6-9,14-16,20,23H,2,5,10-11H2,1H3,(H,24,25)/t14-,15+,16-,20-/m0/s1 YEWAFSVOTWRMHX-QOIOWGMHSA-N 138116 US8871783, 2 Dipeptidyl peptidase 1 17.3 6 25.00 C US Patent 10.7270/Q2F18XF1 aid1800734 US8871783 Anderskewitz, R; Grundl, M; Morschhaeuser, G; Oost, T; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138116&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90441127 249814442 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 271916 CN1C(=O)Cc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)s1 InChI=1S/C23H24N4O2S/c1-27-19-9-14(3-2-13(19)10-21(27)28)20-7-6-18(30-20)11-17(12-24)26-23(29)22-15-4-5-16(8-15)25-22/h2-3,6-7,9,15-17,22,25H,4-5,8,10-11H2,1H3,(H,26,29)/t15-,16+,17-,22-/m0/s1 LCUDGBQZSGOJQH-GEYWLOKFSA-N 138117 US8871783, 3 Dipeptidyl peptidase 1 3.2 6 25.00 C US Patent 10.7270/Q2F18XF1 aid1800734 US8871783 Anderskewitz, R; Grundl, M; Morschhaeuser, G; Oost, T; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138117&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90441128 249814443 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 271917 CN1C(=O)C(=O)c2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)s1 InChI=1S/C23H22N4O3S/c1-27-18-9-12(3-6-17(18)21(28)23(27)30)19-7-5-16(31-19)10-15(11-24)26-22(29)20-13-2-4-14(8-13)25-20/h3,5-7,9,13-15,20,25H,2,4,8,10H2,1H3,(H,26,29)/t13-,14+,15-,20-/m0/s1 GHRQOZDVZXQXNU-YYQBIWNASA-N 138118 US8871783, 4 Dipeptidyl peptidase 1 2.1 6 25.00 C US Patent 10.7270/Q2F18XF1 aid1800734 US8871783 Anderskewitz, R; Grundl, M; Morschhaeuser, G; Oost, T; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138118&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90431086 249814444 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 271918 CN1C(=O)Cc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)o1 InChI=1S/C23H24N4O3/c1-27-19-9-14(3-2-13(19)10-21(27)28)20-7-6-18(30-20)11-17(12-24)26-23(29)22-15-4-5-16(8-15)25-22/h2-3,6-7,9,15-17,22,25H,4-5,8,10-11H2,1H3,(H,26,29)/t15-,16+,17-,22-/m0/s1 COMYBTSVTZPJEO-GEYWLOKFSA-N 138119 US8871783, 5 Dipeptidyl peptidase 1 176.5 6 25.00 C US Patent 10.7270/Q2F18XF1 aid1800734 US8871783 Anderskewitz, R; Grundl, M; Morschhaeuser, G; Oost, T; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138119&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90431087 249814445 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 271919 Brc1ccc2oc(CC(NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)cc2c1 InChI=1S/C18H18BrN3O2/c19-12-2-4-16-11(5-12)7-15(24-16)8-14(9-20)22-18(23)17-10-1-3-13(6-10)21-17/h2,4-5,7,10,13-14,17,21H,1,3,6,8H2,(H,22,23)/t10-,13+,14?,17-/m0/s1 XELBXEASMLFXQL-MPFQSFCLSA-N 138120 US8871783, 6 Dipeptidyl peptidase 1 64.1 6 25.00 C US Patent 10.7270/Q2F18XF1 aid1800734 US8871783 Anderskewitz, R; Grundl, M; Morschhaeuser, G; Oost, T; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138120&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90431089 249814446 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 271920 Fc1cc(ccc1C#N)-c1ccc2oc(CC(NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)cc2c1 InChI=1S/C25H21FN4O2/c26-22-10-15(1-2-17(22)12-27)14-4-6-23-18(7-14)9-21(32-23)11-20(13-28)30-25(31)24-16-3-5-19(8-16)29-24/h1-2,4,6-7,9-10,16,19-20,24,29H,3,5,8,11H2,(H,30,31)/t16-,19+,20?,24-/m0/s1 NPAACGXBNISYFE-BCRPEVRGSA-N 138121 US8871783, 7 Dipeptidyl peptidase 1 39.3 6 25.00 C US Patent 10.7270/Q2F18XF1 aid1800734 US8871783 Anderskewitz, R; Grundl, M; Morschhaeuser, G; Oost, T; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138121&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90431092 249814447 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 271921 CN1C(=O)Cc2ccc(cc12)-c1ccc2oc(CC(NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)cc2c1 InChI=1S/C27H26N4O3/c1-31-23-11-16(2-3-17(23)12-25(31)32)15-5-7-24-19(8-15)10-22(34-24)13-21(14-28)30-27(33)26-18-4-6-20(9-18)29-26/h2-3,5,7-8,10-11,18,20-21,26,29H,4,6,9,12-13H2,1H3,(H,30,33)/t18-,20+,21?,26-/m0/s1 BSKPTJIGROLSFG-IQECEXMCSA-N 138122 US8871783, 8 Dipeptidyl peptidase 1 103.6 6 25.00 C US Patent 10.7270/Q2F18XF1 aid1800734 US8871783 Anderskewitz, R; Grundl, M; Morschhaeuser, G; Oost, T; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138122&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90431181 249814448 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 271922 O=C(NC(Cc1cc2cc(ccc2o1)-c1ccccc1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C24H23N3O2/c25-14-20(27-24(28)23-17-6-8-19(11-17)26-23)13-21-12-18-10-16(7-9-22(18)29-21)15-4-2-1-3-5-15/h1-5,7,9-10,12,17,19-20,23,26H,6,8,11,13H2,(H,27,28)/t17-,19+,20?,23-/m0/s1 DGHQPWFGYWWZMR-GKUGZCSRSA-N 138123 US8871783, 9 Dipeptidyl peptidase 1 62 6 25.00 C US Patent 10.7270/Q2F18XF1 aid1800734 US8871783 Anderskewitz, R; Grundl, M; Morschhaeuser, G; Oost, T; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138123&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90431176 249814449 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 271923 Brc1ccc2sc(CC(NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)cc2c1 InChI=1S/C18H18BrN3OS/c19-12-2-4-16-11(5-12)7-15(24-16)8-14(9-20)22-18(23)17-10-1-3-13(6-10)21-17/h2,4-5,7,10,13-14,17,21H,1,3,6,8H2,(H,22,23)/t10-,13+,14?,17-/m0/s1 ZCMWNWMBXFQJOK-MPFQSFCLSA-N 138124 US8871783, 10 Dipeptidyl peptidase 1 35.8 6 25.00 C US Patent 10.7270/Q2F18XF1 aid1800734 US8871783 Anderskewitz, R; Grundl, M; Morschhaeuser, G; Oost, T; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138124&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90431178 249814450 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 271924 O=C(NC(Cc1cc2cc(ccc2s1)-c1ccccc1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C24H23N3OS/c25-14-20(27-24(28)23-17-6-8-19(11-17)26-23)13-21-12-18-10-16(7-9-22(18)29-21)15-4-2-1-3-5-15/h1-5,7,9-10,12,17,19-20,23,26H,6,8,11,13H2,(H,27,28)/t17-,19+,20?,23-/m0/s1 XHIHMNRULDIWFR-GKUGZCSRSA-N 138125 US8871783, 11 Dipeptidyl peptidase 1 72.8 6 25.00 C US Patent 10.7270/Q2F18XF1 aid1800734 US8871783 Anderskewitz, R; Grundl, M; Morschhaeuser, G; Oost, T; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138125&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90431360 249814451 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 271925 CN1C(=O)Cc2ccc(cc12)-c1cnc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)s1 InChI=1S/C22H23N5O2S/c1-27-17-7-13(3-2-12(17)8-20(27)28)18-11-24-19(30-18)9-16(10-23)26-22(29)21-14-4-5-15(6-14)25-21/h2-3,7,11,14-16,21,25H,4-6,8-9H2,1H3,(H,26,29)/t14-,15+,16?,21-/m0/s1 STMRZFZITLOXOD-DAGLJCOKSA-N 138126 US8871783, 12 Dipeptidyl peptidase 1 14.9 6 25.00 C US Patent 10.7270/Q2F18XF1 aid1800734 US8871783 Anderskewitz, R; Grundl, M; Morschhaeuser, G; Oost, T; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138126&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90431361 249814452 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 271926 CN1C(=O)Cc2ccc(cc12)-c1csc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c1F InChI=1S/C23H23FN4O2S/c1-28-18-7-12(2-3-13(18)8-20(28)29)17-11-31-19(21(17)24)9-16(10-25)27-23(30)22-14-4-5-15(6-14)26-22/h2-3,7,11,14-16,22,26H,4-6,8-9H2,1H3,(H,27,30)/t14-,15+,16?,22-/m0/s1 XFADBMAHLDAHBC-AUNCGFEGSA-N 138127 US8871783, 13 Dipeptidyl peptidase 1 61.7 6 25.00 C US Patent 10.7270/Q2F18XF1 aid1800734 US8871783 Anderskewitz, R; Grundl, M; Morschhaeuser, G; Oost, T; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138127&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90431358 249814453 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 271927 CC(=O)c1ccc(s1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)s1 InChI=1S/C20H21N3O2S2/c1-11(24)16-6-7-18(27-16)17-5-4-15(26-17)9-14(10-21)23-20(25)19-12-2-3-13(8-12)22-19/h4-7,12-14,19,22H,2-3,8-9H2,1H3,(H,23,25)/t12-,13+,14-,19-/m0/s1 JZAUVZHRNFQAMR-LJPSSGMGSA-N 138128 US8871783, 14 Dipeptidyl peptidase 1 13.4 6 25.00 C US Patent 10.7270/Q2F18XF1 aid1800734 US8871783 Anderskewitz, R; Grundl, M; Morschhaeuser, G; Oost, T; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138128&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90431055 249814454 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 271928 CN1C(=O)Cc2ccc(cc12)-c1csc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c1 InChI=1S/C23H24N4O2S/c1-27-20-8-13(2-3-14(20)9-21(27)28)16-7-19(30-12-16)10-18(11-24)26-23(29)22-15-4-5-17(6-15)25-22/h2-3,7-8,12,15,17-18,22,25H,4-6,9-10H2,1H3,(H,26,29)/t15-,17+,18?,22-/m0/s1 PAWBJUGGKOQWEL-JJOTWVSXSA-N 138129 US8871783, 15 Dipeptidyl peptidase 1 41.9 6 25.00 C US Patent 10.7270/Q2F18XF1 aid1800734 US8871783 Anderskewitz, R; Grundl, M; Morschhaeuser, G; Oost, T; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138129&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90431056 249814455 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 271929 CCn1cc(cn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)s1 InChI=1S/C19H23N5OS/c1-2-24-11-13(10-21-24)17-6-5-16(26-17)8-15(9-20)23-19(25)18-12-3-4-14(7-12)22-18/h5-6,10-12,14-15,18,22H,2-4,7-8H2,1H3,(H,23,25)/t12-,14+,15-,18-/m0/s1 HRIIAEYXVPQUHS-OGIUKLMXSA-N 138130 US8871783, 16 Dipeptidyl peptidase 1 17.1 6 25.00 C US Patent 10.7270/Q2F18XF1 aid1800734 US8871783 Anderskewitz, R; Grundl, M; Morschhaeuser, G; Oost, T; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138130 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138130&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90431052 249814456 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 271930 O=C(N[C@@H](Cc1ccc(s1)-c1ccc2CC(=O)Nc2c1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C22H22N4O2S/c23-11-16(25-22(28)21-14-3-4-15(7-14)24-21)10-17-5-6-19(29-17)13-2-1-12-9-20(27)26-18(12)8-13/h1-2,5-6,8,14-16,21,24H,3-4,7,9-10H2,(H,25,28)(H,26,27)/t14-,15+,16-,21-/m0/s1 QWWBBGPYJAFBMA-YJXLLHPSSA-N 138131 US8871783, 17 Dipeptidyl peptidase 1 4.2 6 25.00 C US Patent 10.7270/Q2F18XF1 aid1800734 US8871783 Anderskewitz, R; Grundl, M; Morschhaeuser, G; Oost, T; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138131&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90431054 249814457 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 271931 O=C(N[C@@H](Cc1ccc(s1)-c1cnn(CC2CCOCC2)c1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C23H29N5O2S/c24-11-19(27-23(29)22-16-1-2-18(9-16)26-22)10-20-3-4-21(31-20)17-12-25-28(14-17)13-15-5-7-30-8-6-15/h3-4,12,14-16,18-19,22,26H,1-2,5-10,13H2,(H,27,29)/t16-,18+,19-,22-/m0/s1 DEHMWSJVEVFYAC-ZBPHCFQXSA-N 138132 US8871783, 18 Dipeptidyl peptidase 1 27 6 25.00 C US Patent 10.7270/Q2F18XF1 aid1800734 US8871783 Anderskewitz, R; Grundl, M; Morschhaeuser, G; Oost, T; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138132&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90431170 249814458 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 271932 O=C(N[C@@H](Cc1ccc(s1)-c1ccc2C(=O)OCc2c1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C22H21N3O3S/c23-10-16(25-21(26)20-13-1-3-15(8-13)24-20)9-17-4-6-19(29-17)12-2-5-18-14(7-12)11-28-22(18)27/h2,4-7,13,15-16,20,24H,1,3,8-9,11H2,(H,25,26)/t13-,15+,16-,20-/m0/s1 AVYFSLAYOTWLGT-YEOLMYPVSA-N 138133 US8871783, 19 Dipeptidyl peptidase 1 0.9 6 25.00 C US Patent 10.7270/Q2F18XF1 aid1800734 US8871783 Anderskewitz, R; Grundl, M; Morschhaeuser, G; Oost, T; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138133&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90431171 249814459 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 271933 CN1CCC(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)s1 InChI=1S/C20H28N4OS/c1-24-8-6-13(7-9-24)18-5-4-17(26-18)11-16(12-21)23-20(25)19-14-2-3-15(10-14)22-19/h4-5,13-16,19,22H,2-3,6-11H2,1H3,(H,23,25)/t14-,15+,16-,19-/m0/s1 SMLAWJQGHOCCLG-RCJHGTSTSA-N 138134 US8871783, 20 Dipeptidyl peptidase 1 37.9 6 25.00 C US Patent 10.7270/Q2F18XF1 aid1800734 US8871783 Anderskewitz, R; Grundl, M; Morschhaeuser, G; Oost, T; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138134&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90431166 249814460 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 271934 CN1C(=O)Cc2ccc(cc12)-c1sc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1Br InChI=1S/C23H22BrFN4O2S/c1-29-16-7-13(3-2-11(16)8-18(29)30)22-19(24)20(25)17(32-22)9-15(10-26)28-23(31)21-12-4-5-14(6-12)27-21/h2-3,7,12,14-15,21,27H,4-6,8-9H2,1H3,(H,28,31)/t12-,14+,15?,21-/m0/s1 NHWKJXGSSIPUIY-ZVRQAHGESA-N 138135 US8871783, 21 Dipeptidyl peptidase 1 3.6 6 25.00 C US Patent 10.7270/Q2F18XF1 aid1800734 US8871783 Anderskewitz, R; Grundl, M; Morschhaeuser, G; Oost, T; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138135&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90431169 249814461 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 271935 CN1C(=O)Cc2ccc(cc12)-c1cc(F)c(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)s1 InChI=1S/C23H23FN4O2S/c1-28-18-7-13(3-2-12(18)8-21(28)29)19-10-17(24)20(31-19)9-16(11-25)27-23(30)22-14-4-5-15(6-14)26-22/h2-3,7,10,14-16,22,26H,4-6,8-9H2,1H3,(H,27,30)/t14-,15+,16?,22-/m0/s1 JWPYROQDNOTOGO-AUNCGFEGSA-N 138136 US8871783, 22 Dipeptidyl peptidase 1 2.2 6 25.00 C US Patent 10.7270/Q2F18XF1 aid1800734 US8871783 Anderskewitz, R; Grundl, M; Morschhaeuser, G; Oost, T; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138136&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90431168 249814462 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 271936 CN1CCN(CC1)S(=O)(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)s1 InChI=1S/C25H31N5O3S2/c1-29-10-12-30(13-11-29)35(32,33)22-7-3-17(4-8-22)23-9-6-21(34-23)15-20(16-26)28-25(31)24-18-2-5-19(14-18)27-24/h3-4,6-9,18-20,24,27H,2,5,10-15H2,1H3,(H,28,31)/t18-,19+,20-,24-/m0/s1 KTVUUDSQXGTMCQ-VKDGWMQASA-N 138137 US8871783, 23 Dipeptidyl peptidase 1 2.9 6 25.00 C US Patent 10.7270/Q2F18XF1 aid1800734 US8871783 Anderskewitz, R; Grundl, M; Morschhaeuser, G; Oost, T; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138137&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90441129 249814463 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 271937 CC1(C)OC(=O)c2cc(ccc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)s1 InChI=1S/C24H25N3O3S/c1-24(2)19-7-4-13(10-18(19)23(29)30-24)20-8-6-17(31-20)11-16(12-25)27-22(28)21-14-3-5-15(9-14)26-21/h4,6-8,10,14-16,21,26H,3,5,9,11H2,1-2H3,(H,27,28)/t14-,15+,16-,21-/m0/s1 PIMXMNDRQCKRCD-YJXLLHPSSA-N 138138 US8871783, 24 Dipeptidyl peptidase 1 21.9 6 25.00 C US Patent 10.7270/Q2F18XF1 aid1800734 US8871783 Anderskewitz, R; Grundl, M; Morschhaeuser, G; Oost, T; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138138&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90441130 249814464 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 271938 CC1(C)OC(=O)c2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)s1 InChI=1S/C24H25N3O3S/c1-24(2)19-10-13(4-7-18(19)23(29)30-24)20-8-6-17(31-20)11-16(12-25)27-22(28)21-14-3-5-15(9-14)26-21/h4,6-8,10,14-16,21,26H,3,5,9,11H2,1-2H3,(H,27,28)/t14-,15+,16-,21-/m0/s1 GTXFWAOVSNTSMH-YJXLLHPSSA-N 138139 US8871783, 25 Dipeptidyl peptidase 1 4 6 25.00 C US Patent 10.7270/Q2F18XF1 aid1800734 US8871783 Anderskewitz, R; Grundl, M; Morschhaeuser, G; Oost, T; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138139&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90441131 249814465 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 271939 CS(=O)(=O)c1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)s1 InChI=1S/C21H23N3O3S2/c1-29(26,27)18-4-2-3-13(10-18)19-8-7-17(28-19)11-16(12-22)24-21(25)20-14-5-6-15(9-14)23-20/h2-4,7-8,10,14-16,20,23H,5-6,9,11H2,1H3,(H,24,25)/t14-,15+,16-,20-/m0/s1 IMBTWQZGEZDVOU-QOIOWGMHSA-N 138140 US8871783, 26 Dipeptidyl peptidase 1 16.7 6 25.00 C US Patent 10.7270/Q2F18XF1 aid1800734 US8871783 Anderskewitz, R; Grundl, M; Morschhaeuser, G; Oost, T; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138140 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138140&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90441132 249814466 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 273799 CS(=O)(=O)c1cc(ccc1C#N)-c1ccc(C[C@H](NC(=O)C23CCC(CC2)CN3)C#N)c(F)c1 InChI=1S/C25H25FN4O3S/c1-34(32,33)23-12-18(3-5-20(23)13-27)17-2-4-19(22(26)11-17)10-21(14-28)30-24(31)25-8-6-16(7-9-25)15-29-25/h2-5,11-12,16,21,29H,6-10,15H2,1H3,(H,30,31)/t16?,21-,25?/m0/s1 WTFPMTZBRYAXAT-MHVXWQKQSA-N 139503 US8889708, 1 Dipeptidyl peptidase 1 10.9 25.00 C US Patent 10.7270/Q2JM28BB aid1800770 US8889708 Grauert, M; Anderskewitz, R; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=139503 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=139503&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430914 249870971 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 273800 CN1C(=O)Cc2ccc(cc12)-c1ccc(C[C@H](NC(=O)C23CCC(CC2)CN3)C#N)cc1 InChI=1S/C26H28N4O2/c1-30-23-13-20(6-7-21(23)14-24(30)31)19-4-2-17(3-5-19)12-22(15-27)29-25(32)26-10-8-18(9-11-26)16-28-26/h2-7,13,18,22,28H,8-12,14,16H2,1H3,(H,29,32)/t18?,22-,26?/m0/s1 FLUKFHZYRHSYID-ZRTADFRUSA-N 139504 US8889708, 2 Dipeptidyl peptidase 1 17.1 25.00 C US Patent 10.7270/Q2JM28BB aid1800770 US8889708 Grauert, M; Anderskewitz, R; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=139504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=139504&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430923 249870972 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 273801 CS(=O)(=O)c1cc(ccc1C#N)-c1ccc(C[C@H](NC(=O)C23CCC(CC2)CN3)C#N)cc1 InChI=1S/C25H26N4O3S/c1-33(31,32)23-13-20(6-7-21(23)14-26)19-4-2-17(3-5-19)12-22(15-27)29-24(30)25-10-8-18(9-11-25)16-28-25/h2-7,13,18,22,28H,8-12,16H2,1H3,(H,29,30)/t18?,22-,25?/m0/s1 KMWDHMSUUMKGQS-JMNVSDKBSA-N 139505 US8889708, 3 Dipeptidyl peptidase 1 35.7 25.00 C US Patent 10.7270/Q2JM28BB aid1800770 US8889708 Grauert, M; Anderskewitz, R; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=139505 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=139505&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430920 249870973 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 273802 CN1Cc2cc(ccc2C1=O)-c1ccc(C[C@H](NC(=O)C23CCC(CC2)CN3)C#N)cc1 InChI=1S/C26H28N4O2/c1-30-16-21-13-20(6-7-23(21)24(30)31)19-4-2-17(3-5-19)12-22(14-27)29-25(32)26-10-8-18(9-11-26)15-28-26/h2-7,13,18,22,28H,8-12,15-16H2,1H3,(H,29,32)/t18?,22-,26?/m0/s1 NOSUEQLRRACAQS-ZRTADFRUSA-N 139506 US8889708, 4 Dipeptidyl peptidase 1 50.1 25.00 C US Patent 10.7270/Q2JM28BB aid1800770 US8889708 Grauert, M; Anderskewitz, R; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=139506 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=139506&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90455078 249870974 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 273803 CN1C(=O)Cc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@]23C[C@H](CN2)OCC3)C#N)cc1 InChI=1S/C25H26N4O3/c1-29-22-11-18(6-7-19(22)12-23(29)30)17-4-2-16(3-5-17)10-20(14-26)28-24(31)25-8-9-32-21(13-25)15-27-25/h2-7,11,20-21,27H,8-10,12-13,15H2,1H3,(H,28,31)/t20-,21+,25-/m0/s1 FNFKANIAANVVRI-BKSPAHHJSA-N 139507 US8889708, 5 Dipeptidyl peptidase 1 50.3 25.00 C US Patent 10.7270/Q2JM28BB aid1800770 US8889708 Grauert, M; Anderskewitz, R; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=139507 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=139507&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90431018 249870975 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 273804 CS(=O)(=O)c1cc(ccc1C#N)-c1ccc(C[C@H](NC(=O)[C@]23C[C@H](CN2)OCC3)C#N)cc1 InChI=1S/C24H24N4O4S/c1-33(30,31)22-11-18(6-7-19(22)13-25)17-4-2-16(3-5-17)10-20(14-26)28-23(29)24-8-9-32-21(12-24)15-27-24/h2-7,11,20-21,27H,8-10,12,15H2,1H3,(H,28,29)/t20-,21+,24-/m0/s1 WLMFIVMXLXFOJU-IMSXRSKXSA-N 139508 US8889708, 6 Dipeptidyl peptidase 1 201.8 25.00 C US Patent 10.7270/Q2JM28BB aid1800770 US8889708 Grauert, M; Anderskewitz, R; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=139508 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=139508&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90431019 249870976 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 273805 CN1C(=O)Cc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@]23CC[C@@H](CN2)C3)C#N)cc1 InChI=1S/C25H26N4O2/c1-29-22-11-19(6-7-20(22)12-23(29)30)18-4-2-16(3-5-18)10-21(14-26)28-24(31)25-9-8-17(13-25)15-27-25/h2-7,11,17,21,27H,8-10,12-13,15H2,1H3,(H,28,31)/t17-,21+,25-/m1/s1 UZYGCBGSFBCHRH-FTGWLVSGSA-N 139509 US8889708, 7 Dipeptidyl peptidase 1 204.4 25.00 C US Patent 10.7270/Q2JM28BB aid1800770 US8889708 Grauert, M; Anderskewitz, R; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=139509 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=139509&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 86272031 249870977 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 273806 CN1C(=O)Cc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@]23CC[C@H](CN2)C3)C#N)cc1 InChI=1S/C25H26N4O2/c1-29-22-11-19(6-7-20(22)12-23(29)30)18-4-2-16(3-5-18)10-21(14-26)28-24(31)25-9-8-17(13-25)15-27-25/h2-7,11,17,21,27H,8-10,12-13,15H2,1H3,(H,28,31)/t17-,21-,25-/m0/s1 UZYGCBGSFBCHRH-ADSMNUKGSA-N 139510 US8889708, 8 Dipeptidyl peptidase 1 221 25.00 C US Patent 10.7270/Q2JM28BB aid1800770 US8889708 Grauert, M; Anderskewitz, R; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=139510 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=139510&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 86275385 249870978 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 273807 CN1C(=O)Cc2ccc(cc12)-c1ccc(C[C@H](NC(=O)C23CCOC(CCN2)C3)C#N)cc1 InChI=1S/C26H28N4O3/c1-30-23-13-19(6-7-20(23)14-24(30)31)18-4-2-17(3-5-18)12-21(16-27)29-25(32)26-9-11-33-22(15-26)8-10-28-26/h2-7,13,21-22,28H,8-12,14-15H2,1H3,(H,29,32)/t21-,22?,26?/m0/s1 SVWPHMXSWNIINX-OKFDZGCWSA-N 139511 US8889708, 9 Dipeptidyl peptidase 1 227.8 25.00 C US Patent 10.7270/Q2JM28BB aid1800770 US8889708 Grauert, M; Anderskewitz, R; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=139511 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=139511&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 86275611 249870979 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 273808 CS(=O)(=O)c1cc(ccc1C#N)-c1ccc(C[C@H](NC(=O)[C@@]23CC[C@H](CN2)C3)C#N)cc1 InChI=1S/C24H24N4O3S/c1-32(30,31)22-11-19(6-7-20(22)13-25)18-4-2-16(3-5-18)10-21(14-26)28-23(29)24-9-8-17(12-24)15-27-24/h2-7,11,17,21,27H,8-10,12,15H2,1H3,(H,28,29)/t17-,21-,24-/m0/s1 PZLHFILSWHGRPR-JBUDQFAYSA-N 139512 US8889708, 10 Dipeptidyl peptidase 1 283.4 25.00 C US Patent 10.7270/Q2JM28BB aid1800770 US8889708 Grauert, M; Anderskewitz, R; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=139512 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=139512&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 86275612 249870980 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 273809 Fc1cc(ccc1C#N)-c1ccc(C[C@H](NC(=O)C23CCC(CC2)N3)C#N)cc1 InChI=1S/C23H21FN4O/c24-21-12-17(5-6-18(21)13-25)16-3-1-15(2-4-16)11-20(14-26)27-22(29)23-9-7-19(28-23)8-10-23/h1-6,12,19-20,28H,7-11H2,(H,27,29)/t19?,20-,23?/m0/s1 GKQJTUJNAOVIAL-KQVJYAISSA-N 139513 US8889708, 11 Dipeptidyl peptidase 1 284 25.00 C US Patent 10.7270/Q2JM28BB aid1800770 US8889708 Grauert, M; Anderskewitz, R; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=139513 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=139513&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90453388 249870981 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 273810 CN1C(=O)Cc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@]23C[C@H](CN2)CCC3)C#N)cc1 InChI=1S/C26H28N4O2/c1-30-23-12-20(8-9-21(23)13-24(30)31)19-6-4-17(5-7-19)11-22(15-27)29-25(32)26-10-2-3-18(14-26)16-28-26/h4-9,12,18,22,28H,2-3,10-11,13-14,16H2,1H3,(H,29,32)/t18-,22+,26-/m1/s1 CQFITGWARHHCOQ-QGUBCYKSSA-N 139514 US8889708, 12 Dipeptidyl peptidase 1 427.7 25.00 C US Patent 10.7270/Q2JM28BB aid1800770 US8889708 Grauert, M; Anderskewitz, R; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=139514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=139514&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430989 249870982 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 273811 CN1Cc2cc(ccc2C1=O)-c1ccc(C[C@H](NC(=O)[C@@]23CC[C@H](CN2)C3)C#N)cc1 InChI=1S/C25H26N4O2/c1-29-15-20-11-19(6-7-22(20)23(29)30)18-4-2-16(3-5-18)10-21(13-26)28-24(31)25-9-8-17(12-25)14-27-25/h2-7,11,17,21,27H,8-10,12,14-15H2,1H3,(H,28,31)/t17-,21-,25-/m0/s1 ZGJAUWYMQXFVHS-ADSMNUKGSA-N 139515 US8889708, 13 Dipeptidyl peptidase 1 500.9 25.00 C US Patent 10.7270/Q2JM28BB aid1800770 US8889708 Grauert, M; Anderskewitz, R; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=139515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=139515&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 86272026 249870983 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 273812 CS(=O)(=O)c1cc(ccc1C#N)-c1ccc(C[C@H](NC(=O)[C@]23CC[C@@H](CN2)C3)C#N)cc1 InChI=1S/C24H24N4O3S/c1-32(30,31)22-11-19(6-7-20(22)13-25)18-4-2-16(3-5-18)10-21(14-26)28-23(29)24-9-8-17(12-24)15-27-24/h2-7,11,17,21,27H,8-10,12,15H2,1H3,(H,28,29)/t17-,21+,24-/m1/s1 PZLHFILSWHGRPR-QATBIIFWSA-N 139516 US8889708, 14 Dipeptidyl peptidase 1 649.5 25.00 C US Patent 10.7270/Q2JM28BB aid1800770 US8889708 Grauert, M; Anderskewitz, R; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=139516 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=139516&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 86272272 249870984 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 273813 CS(=O)(=O)c1cc(ccc1C#N)-c1ccc(C[C@H](NC(=O)[C@@]23C[C@H](CN2)CCC3)C#N)cc1 InChI=1S/C25H26N4O3S/c1-33(31,32)23-12-20(8-9-21(23)14-26)19-6-4-17(5-7-19)11-22(15-27)29-24(30)25-10-2-3-18(13-25)16-28-25/h4-9,12,18,22,28H,2-3,10-11,13,16H2,1H3,(H,29,30)/t18-,22+,25-/m1/s1 FDUAQHDMKJKRLP-WSUBETFTSA-N 139517 US8889708, 16 Dipeptidyl peptidase 1 1216 25.00 C US Patent 10.7270/Q2JM28BB aid1800770 US8889708 Grauert, M; Anderskewitz, R; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=139517 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=139517&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430994 249870985 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 273814 CN1Cc2cc(ccc2C1=O)-c1ccc(C[C@H](NC(=O)[C@]23CC[C@@H](CN2)C3)C#N)cc1 InChI=1S/C25H26N4O2/c1-29-15-20-11-19(6-7-22(20)23(29)30)18-4-2-16(3-5-18)10-21(13-26)28-24(31)25-9-8-17(12-25)14-27-25/h2-7,11,17,21,27H,8-10,12,14-15H2,1H3,(H,28,31)/t17-,21+,25-/m1/s1 ZGJAUWYMQXFVHS-FTGWLVSGSA-N 139518 US8889708, 17 Dipeptidyl peptidase 1 1440 25.00 C US Patent 10.7270/Q2JM28BB aid1800770 US8889708 Grauert, M; Anderskewitz, R; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=139518 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=139518&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430990 249870986 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 273815 CS(=O)(=O)c1ccc(cc1C#N)-c1ccc(C[C@H](NC(=O)C23CCC(CC2)CN3)C#N)c(F)c1 InChI=1S/C25H25FN4O3S/c1-34(32,33)23-5-4-17(10-20(23)13-27)18-2-3-19(22(26)12-18)11-21(14-28)30-24(31)25-8-6-16(7-9-25)15-29-25/h2-5,10,12,16,21,29H,6-9,11,15H2,1H3,(H,30,31)/t16?,21-,25?/m0/s1 JGYHOEBIUVOQSS-MHVXWQKQSA-N 139519 US8889708, 18 Dipeptidyl peptidase 1 15 25.00 C US Patent 10.7270/Q2JM28BB aid1800770 US8889708 Grauert, M; Anderskewitz, R; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=139519 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=139519&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90455070 249870987 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 273816 CN1Cc2ccc(cc2C1)-c1ccc(C[C@H](NC(=O)C23CCC(CC2)CN3)C#N)c(F)c1 InChI=1S/C26H29FN4O/c1-31-15-21-5-3-18(10-22(21)16-31)19-2-4-20(24(27)12-19)11-23(13-28)30-25(32)26-8-6-17(7-9-26)14-29-26/h2-5,10,12,17,23,29H,6-9,11,14-16H2,1H3,(H,30,32)/t17?,23-,26?/m0/s1 UHUZLOSMMRTYQJ-SPYQMNCUSA-N 139520 US8889708, 19 Dipeptidyl peptidase 1 38.1 25.00 C US Patent 10.7270/Q2JM28BB aid1800770 US8889708 Grauert, M; Anderskewitz, R; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=139520 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=139520&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430991 249870988 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 273817 CN1Cc2cc(ccc2S1(=O)=O)-c1ccc(C[C@H](NC(=O)C23CCC(CC2)CN3)C#N)c(F)c1 InChI=1S/C25H27FN4O3S/c1-30-15-20-10-17(4-5-23(20)34(30,32)33)18-2-3-19(22(26)12-18)11-21(13-27)29-24(31)25-8-6-16(7-9-25)14-28-25/h2-5,10,12,16,21,28H,6-9,11,14-15H2,1H3,(H,29,31)/t16?,21-,25?/m0/s1 IWDPYYJKNIFBCR-MHVXWQKQSA-N 139521 US8889708, 20 Dipeptidyl peptidase 1 17.6 25.00 C US Patent 10.7270/Q2JM28BB aid1800770 US8889708 Grauert, M; Anderskewitz, R; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=139521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=139521&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430992 249870989 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 273818 CS(=O)(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)C23CCC(CC2)CN3)C#N)c(F)c1 InChI=1S/C24H26FN3O3S/c1-32(30,31)21-6-4-17(5-7-21)18-2-3-19(22(25)13-18)12-20(14-26)28-23(29)24-10-8-16(9-11-24)15-27-24/h2-7,13,16,20,27H,8-12,15H2,1H3,(H,28,29)/t16?,20-,24?/m0/s1 YLYRPDLKZYLBQM-XUGLNINTSA-N 139522 US8889708, 21 Dipeptidyl peptidase 1 17 25.00 C US Patent 10.7270/Q2JM28BB aid1800770 US8889708 Grauert, M; Anderskewitz, R; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=139522 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=139522&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90407286 249870990 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 273819 Fc1cc(ccc1C[C@H](NC(=O)C12CCC(CC1)CN2)C#N)-c1ccc2C(=O)NCCc2c1 InChI=1S/C26H27FN4O2/c27-23-13-18(17-3-4-22-19(11-17)7-10-29-24(22)32)1-2-20(23)12-21(14-28)31-25(33)26-8-5-16(6-9-26)15-30-26/h1-4,11,13,16,21,30H,5-10,12,15H2,(H,29,32)(H,31,33)/t16?,21-,26?/m0/s1 BSFQMPWXCVTLQQ-JAHBGFQISA-N 139523 US8889708, 22 Dipeptidyl peptidase 1 6.8 25.00 C US Patent 10.7270/Q2JM28BB aid1800770 US8889708 Grauert, M; Anderskewitz, R; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=139523 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=139523&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430941 249870991 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 273820 Fc1cc(ccc1C[C@H](NC(=O)C12CCC(CC1)CN2)C#N)-c1ccc2CC(=O)Nc2c1 InChI=1S/C25H25FN4O2/c26-21-10-16(17-2-4-19-12-23(31)30-22(19)11-17)1-3-18(21)9-20(13-27)29-24(32)25-7-5-15(6-8-25)14-28-25/h1-4,10-11,15,20,28H,5-9,12,14H2,(H,29,32)(H,30,31)/t15?,20-,25?/m0/s1 NLFOFOVCNGNZSN-RSASLARPSA-N 139524 US8889708, 23 Dipeptidyl peptidase 1 6.6 25.00 C US Patent 10.7270/Q2JM28BB aid1800770 US8889708 Grauert, M; Anderskewitz, R; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=139524 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=139524&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430943 249870992 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 273821 NC(=O)c1cccc(c1)-c1ccc(C[C@H](NC(=O)C23CCC(CC2)CN3)C#N)c(F)c1 InChI=1S/C24H25FN4O2/c25-21-12-17(16-2-1-3-19(10-16)22(27)30)4-5-18(21)11-20(13-26)29-23(31)24-8-6-15(7-9-24)14-28-24/h1-5,10,12,15,20,28H,6-9,11,14H2,(H2,27,30)(H,29,31)/t15?,20-,24?/m0/s1 YBQSDADTRJHWJH-QOTJCZOLSA-N 139525 US8889708, 24 Dipeptidyl peptidase 1 11.2 25.00 C US Patent 10.7270/Q2JM28BB aid1800770 US8889708 Grauert, M; Anderskewitz, R; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=139525 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=139525&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430942 249870993 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 273822 CN1C(=O)C(C)(C)c2ccc(cc12)-c1ccc(C[C@H](NC(=O)C23CCC(CC2)CN3)C#N)c(F)c1 InChI=1S/C28H31FN4O2/c1-27(2)22-7-6-19(14-24(22)33(3)26(27)35)18-4-5-20(23(29)13-18)12-21(15-30)32-25(34)28-10-8-17(9-11-28)16-31-28/h4-7,13-14,17,21,31H,8-12,16H2,1-3H3,(H,32,34)/t17?,21-,28?/m0/s1 JIPWGXJJZZYQSN-VXBYCZGMSA-N 139526 US8889708, 25 Dipeptidyl peptidase 1 40.7 25.00 C US Patent 10.7270/Q2JM28BB aid1800770 US8889708 Grauert, M; Anderskewitz, R; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=139526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=139526&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430948 249870994 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 273823 COCCN1C(=O)Cc2ccc(cc12)-c1ccc(C[C@H](NC(=O)C23CCC(CC2)CN3)C#N)c(F)c1 InChI=1S/C28H31FN4O3/c1-36-11-10-33-25-14-20(3-5-22(25)15-26(33)34)19-2-4-21(24(29)13-19)12-23(16-30)32-27(35)28-8-6-18(7-9-28)17-31-28/h2-5,13-14,18,23,31H,6-12,15,17H2,1H3,(H,32,35)/t18?,23-,28?/m0/s1 WBTVTPVSPARIMI-OVMDUCBGSA-N 139527 US8889708, 26 Dipeptidyl peptidase 1 4.3 25.00 C US Patent 10.7270/Q2JM28BB aid1800770 US8889708 Grauert, M; Anderskewitz, R; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=139527 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=139527&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430950 249870995 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 273824 CC1(C)OC(=O)c2ccc(cc12)-c1ccc(C[C@H](NC(=O)C23CCC(CC2)CN3)C#N)c(F)c1 InChI=1S/C27H28FN3O3/c1-26(2)22-12-17(5-6-21(22)24(32)34-26)18-3-4-19(23(28)13-18)11-20(14-29)31-25(33)27-9-7-16(8-10-27)15-30-27/h3-6,12-13,16,20,30H,7-11,15H2,1-2H3,(H,31,33)/t16?,20-,27?/m0/s1 BOERWDYDLJFILM-FBSITZRHSA-N 139528 US8889708, 27 Dipeptidyl peptidase 1 2.2 25.00 C US Patent 10.7270/Q2JM28BB aid1800770 US8889708 Grauert, M; Anderskewitz, R; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=139528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=139528&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430945 249870996 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 273825 CN1C(=O)Cc2ccc(cc12)-c1ccc(C[C@H](NC(=O)C23CCC(CC2)CN3)C#N)c(F)c1 InChI=1S/C26H27FN4O2/c1-31-23-12-18(3-5-20(23)13-24(31)32)17-2-4-19(22(27)11-17)10-21(14-28)30-25(33)26-8-6-16(7-9-26)15-29-26/h2-5,11-12,16,21,29H,6-10,13,15H2,1H3,(H,30,33)/t16?,21-,26?/m0/s1 LNAMPFAYVPAARV-JAHBGFQISA-N 139529 US8889708, 28 Dipeptidyl peptidase 1 4.9 25.00 C US Patent 10.7270/Q2JM28BB aid1800770 US8889708 Grauert, M; Anderskewitz, R; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=139529 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=139529&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430946 249870997 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 273826 Fc1cc(ccc1C[C@H](NC(=O)C12CCC(CC1)CN2)C#N)-c1cnn(CC2CCOCC2)c1 InChI=1S/C26H32FN5O2/c27-24-12-20(22-15-30-32(17-22)16-19-5-9-34-10-6-19)1-2-21(24)11-23(13-28)31-25(33)26-7-3-18(4-8-26)14-29-26/h1-2,12,15,17-19,23,29H,3-11,14,16H2,(H,31,33)/t18?,23-,26?/m0/s1 FIBMSYAXRBDRDO-DTWLZNLASA-N 139530 US8889708, 29 Dipeptidyl peptidase 1 20.2 25.00 C US Patent 10.7270/Q2JM28BB aid1800770 US8889708 Grauert, M; Anderskewitz, R; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=139530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=139530&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430987 249870998 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 273827 CN(C)S(=O)(=O)c1cccc(c1)-c1ccc(C[C@H](NC(=O)C23CCC(CC2)CN3)C#N)c(F)c1 InChI=1S/C25H29FN4O3S/c1-30(2)34(32,33)22-5-3-4-18(13-22)19-6-7-20(23(26)14-19)12-21(15-27)29-24(31)25-10-8-17(9-11-25)16-28-25/h3-7,13-14,17,21,28H,8-12,16H2,1-2H3,(H,29,31)/t17?,21-,25?/m0/s1 HADXXGZZVJADQZ-TUHXZXAOSA-N 139531 US8889708, 30 Dipeptidyl peptidase 1 6.7 25.00 C US Patent 10.7270/Q2JM28BB aid1800770 US8889708 Grauert, M; Anderskewitz, R; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=139531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=139531&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430986 249870999 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 273828 NC(=O)c1cc(cs1)-c1ccc(C[C@H](NC(=O)C23CCC(CC2)CN3)C#N)c(F)c1 InChI=1S/C22H23FN4O2S/c23-18-8-14(16-9-19(20(25)28)30-12-16)1-2-15(18)7-17(10-24)27-21(29)22-5-3-13(4-6-22)11-26-22/h1-2,8-9,12-13,17,26H,3-7,11H2,(H2,25,28)(H,27,29)/t13?,17-,22?/m0/s1 AQJIKVTXFPNTKB-YBEBCVOYSA-N 139532 US8889708, 31 Dipeptidyl peptidase 1 4.3 25.00 C US Patent 10.7270/Q2JM28BB aid1800770 US8889708 Grauert, M; Anderskewitz, R; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=139532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=139532&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430985 249871000 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 272624 CS(=O)(=O)c1cc(ccc1C#N)-c1ccc(C[C@H](NC(=O)[C@H]2NC3CCC2CC3)C#N)c(F)c1 InChI=1S/C25H25FN4O3S/c1-34(32,33)23-12-17(3-5-19(23)13-27)16-2-4-18(22(26)11-16)10-21(14-28)30-25(31)24-15-6-8-20(29-24)9-7-15/h2-5,11-12,15,20-21,24,29H,6-10H2,1H3,(H,30,31)/t15?,20?,21-,24-/m0/s1 PESMPBFESLYXPO-SKSZBOKFSA-N 138492 US8877775, 1::US9073869, 1 Dipeptidyl peptidase 1 30.1 6 25.00 C US Patent 10.7270/Q20R9N3T aid1800748 US8877775 Anderskewitz, R; Grauert, M; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138492 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138492&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 86269133 249815717 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 272625 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2CC(=O)Nc2c1)C#N)[C@H]1NC2CCC1CC2 InChI=1S/C25H26N4O2/c26-14-21(28-25(31)24-17-7-9-20(27-24)10-8-17)11-15-1-3-16(4-2-15)18-5-6-19-13-23(30)29-22(19)12-18/h1-6,12,17,20-21,24,27H,7-11,13H2,(H,28,31)(H,29,30)/t17?,20?,21-,24-/m0/s1 ZFWQZYVYJVNWLV-WBEBZIJESA-N 138493 US8877775, 2::US9073869, 2 Dipeptidyl peptidase 1 50.1 6 25.00 C US Patent 10.7270/Q20R9N3T aid1800748 US8877775 Anderskewitz, R; Grauert, M; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138493 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138493&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90415608 249815718 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 272626 CN1C(=O)Cc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3CC[C@@H]2CC3)C#N)cc1 InChI=1S/C26H28N4O2/c1-30-23-13-19(6-7-20(23)14-24(30)31)17-4-2-16(3-5-17)12-22(15-27)29-26(32)25-18-8-10-21(28-25)11-9-18/h2-7,13,18,21-22,25,28H,8-12,14H2,1H3,(H,29,32)/t18-,21+,22-,25-/m0/s1 GGTCSHNAVPBGDV-DHDULZGNSA-N 138494 US8877775, 4::US9073869, 4 Dipeptidyl peptidase 1 32.2 6 25.00 C US Patent 10.7270/Q20R9N3T aid1800748 US8877775 Anderskewitz, R; Grauert, M; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138494 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138494&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90436465 249815719 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 272627 CN1C(=O)Cc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2NC3CCC2CC3)C#N)cc1 InChI=1S/C26H28N4O2/c1-30-23-13-19(6-7-20(23)14-24(30)31)17-4-2-16(3-5-17)12-22(15-27)29-26(32)25-18-8-10-21(28-25)11-9-18/h2-7,13,18,21-22,25,28H,8-12,14H2,1H3,(H,29,32)/t18?,21?,22-,25-/m0/s1 GGTCSHNAVPBGDV-OJDUGZSWSA-N 138495 US8877775, 6::US9073869, 6 Dipeptidyl peptidase 1 52.2 6 25.00 C US Patent 10.7270/Q20R9N3T aid1800748 US8877775 Anderskewitz, R; Grauert, M; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138495&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90436465 249815720 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 272628 Fc1cc(ccc1C#N)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3CC[C@@H]2CC3)C#N)cc1 InChI=1S/C24H23FN4O/c25-22-12-18(5-6-19(22)13-26)16-3-1-15(2-4-16)11-21(14-27)29-24(30)23-17-7-9-20(28-23)10-8-17/h1-6,12,17,20-21,23,28H,7-11H2,(H,29,30)/t17-,20+,21-,23-/m0/s1 JAEPUSZQVMPGCR-OOIKZJQMSA-N 138496 US8877775, 7::US9073869, 7 Dipeptidyl peptidase 1 66.4 6 25.00 C US Patent 10.7270/Q20R9N3T aid1800748 US8877775 Anderskewitz, R; Grauert, M; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138496&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90418514 249815721 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 272629 CS(=O)(=O)c1cc(ccc1C#N)-c1ccc(C[C@H](NC(=O)[C@H]2NC3CCC2CC3)C#N)cc1 InChI=1S/C25H26N4O3S/c1-33(31,32)23-13-19(6-7-20(23)14-26)17-4-2-16(3-5-17)12-22(15-27)29-25(30)24-18-8-10-21(28-24)11-9-18/h2-7,13,18,21-22,24,28H,8-12H2,1H3,(H,29,30)/t18?,21?,22-,24-/m0/s1 VEFUKSHSYMURRC-YRTXYGLRSA-N 138497 US8877775, 8::US9073869, 8 Dipeptidyl peptidase 1 70.2 6 25.00 C US Patent 10.7270/Q20R9N3T aid1800748 US8877775 Anderskewitz, R; Grauert, M; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138497&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90436475 249815722 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 272630 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)[C@H]1NC2CCC1CC2 InChI=1S/C24H24N4O/c25-14-17-3-7-19(8-4-17)18-5-1-16(2-6-18)13-22(15-26)28-24(29)23-20-9-11-21(27-23)12-10-20/h1-8,20-23,27H,9-13H2,(H,28,29)/t20?,21?,22-,23-/m0/s1 HZEOMWCQPYUDTQ-BBITVKMKSA-N 138498 US8877775, 9::US9073869, 9 Dipeptidyl peptidase 1 73 6 25.00 C US Patent 10.7270/Q20R9N3T aid1800748 US8877775 Anderskewitz, R; Grauert, M; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138498 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138498&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90436472 249815723 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 272631 CS(=O)(=O)c1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2NC3CCC2CC3)C#N)cc1 InChI=1S/C24H27N3O3S/c1-31(29,30)22-4-2-3-19(14-22)17-7-5-16(6-8-17)13-21(15-25)27-24(28)23-18-9-11-20(26-23)12-10-18/h2-8,14,18,20-21,23,26H,9-13H2,1H3,(H,27,28)/t18?,20?,21-,23-/m0/s1 CAXHANKBDIZCAM-JGAJYACASA-N 138499 US8877775, 10::US9073869, 10 Dipeptidyl peptidase 1 73.5 6 25.00 C US Patent 10.7270/Q20R9N3T aid1800748 US8877775 Anderskewitz, R; Grauert, M; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138499&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90436473 249815724 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 272632 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2C(=O)NCc2c1)C#N)[C@H]1NC2CCC1CC2 InChI=1S/C25H26N4O2/c26-13-21(29-25(31)23-17-5-8-20(28-23)9-6-17)11-15-1-3-16(4-2-15)18-7-10-22-19(12-18)14-27-24(22)30/h1-4,7,10,12,17,20-21,23,28H,5-6,8-9,11,14H2,(H,27,30)(H,29,31)/t17?,20?,21-,23-/m0/s1 IXYJOIPTPRUCPY-MBNYALJRSA-N 138500 US8877775, 11::US9073869, 11 Dipeptidyl peptidase 1 86.7 6 25.00 C US Patent 10.7270/Q20R9N3T aid1800748 US8877775 Anderskewitz, R; Grauert, M; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138500&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90436474 249815725 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 272633 CS(=O)(=O)Nc1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2NC3CCC2CC3)C#N)cc1 InChI=1S/C24H28N4O3S/c1-32(30,31)28-21-4-2-3-19(14-21)17-7-5-16(6-8-17)13-22(15-25)27-24(29)23-18-9-11-20(26-23)12-10-18/h2-8,14,18,20,22-23,26,28H,9-13H2,1H3,(H,27,29)/t18?,20?,22-,23-/m0/s1 PDCURQYDVFHGAB-FRZIOBBBSA-N 138501 US8877775, 12::US9073869, 12 Dipeptidyl peptidase 1 97.4 6 25.00 C US Patent 10.7270/Q20R9N3T aid1800748 US8877775 Anderskewitz, R; Grauert, M; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138501&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90436508 249815726 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 272634 NS(=O)(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2NC3CCC2CC3)C#N)cc1 InChI=1S/C23H26N4O3S/c24-14-20(27-23(28)22-18-5-9-19(26-22)10-6-18)13-15-1-3-16(4-2-15)17-7-11-21(12-8-17)31(25,29)30/h1-4,7-8,11-12,18-20,22,26H,5-6,9-10,13H2,(H,27,28)(H2,25,29,30)/t18?,19?,20-,22-/m0/s1 NSXPQYOXGHDKCW-IRIHCNEDSA-N 138502 US8877775, 13::US9073869, 13 Dipeptidyl peptidase 1 102.3 6 25.00 C US Patent 10.7270/Q20R9N3T aid1800748 US8877775 Anderskewitz, R; Grauert, M; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138502&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 86269343 249815727 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 272635 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2NC(=O)Cc2c1)C#N)[C@H]1NC2CCC1CC2 InChI=1S/C25H26N4O2/c26-14-21(28-25(31)24-17-5-8-20(27-24)9-6-17)11-15-1-3-16(4-2-15)18-7-10-22-19(12-18)13-23(30)29-22/h1-4,7,10,12,17,20-21,24,27H,5-6,8-9,11,13H2,(H,28,31)(H,29,30)/t17?,20?,21-,24-/m0/s1 COXAXXLYTPEMAM-WBEBZIJESA-N 138503 US8877775, 14::US9073869, 14 Dipeptidyl peptidase 1 102.8 6 25.00 C US Patent 10.7270/Q20R9N3T aid1800748 US8877775 Anderskewitz, R; Grauert, M; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138503 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138503&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 86269539 249815728 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 272636 CS(=O)(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2NC3CCC2CC3)C#N)cc1 InChI=1S/C24H27N3O3S/c1-31(29,30)22-12-8-18(9-13-22)17-4-2-16(3-5-17)14-21(15-25)27-24(28)23-19-6-10-20(26-23)11-7-19/h2-5,8-9,12-13,19-21,23,26H,6-7,10-11,14H2,1H3,(H,27,28)/t19?,20?,21-,23-/m0/s1 AOJJBOPIQYRTLE-JRJYRQGGSA-N 138504 US8877775, 15::US9073869, 15 Dipeptidyl peptidase 1 110.5 6 25.00 C US Patent 10.7270/Q20R9N3T aid1800748 US8877775 Anderskewitz, R; Grauert, M; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138504&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 86269540 249815729 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 272637 NC(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2NC3CCC2CC3)C#N)cc1 InChI=1S/C24H26N4O2/c25-14-21(28-24(30)22-18-9-11-20(27-22)12-10-18)13-15-1-3-16(4-2-15)17-5-7-19(8-6-17)23(26)29/h1-8,18,20-22,27H,9-13H2,(H2,26,29)(H,28,30)/t18?,20?,21-,22-/m0/s1 DJKSTDKRJHBEOC-QJWFJBDNSA-N 138505 US8877775, 16::US9073869, 16 Dipeptidyl peptidase 1 118 6 25.00 C US Patent 10.7270/Q20R9N3T aid1800748 US8877775 Anderskewitz, R; Grauert, M; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138505 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138505&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 86269541 249815730 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 272638 CS(=O)(=O)Nc1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2NC3CCC2CC3)C#N)cc1 InChI=1S/C24H28N4O3S/c1-32(30,31)28-21-12-6-18(7-13-21)17-4-2-16(3-5-17)14-22(15-25)27-24(29)23-19-8-10-20(26-23)11-9-19/h2-7,12-13,19-20,22-23,26,28H,8-11,14H2,1H3,(H,27,29)/t19?,20?,22-,23-/m0/s1 MGSFLXHCILBYOG-AEDUHMMZSA-N 138506 US8877775, 17::US9073869, 17 Dipeptidyl peptidase 1 123.7 6 25.00 C US Patent 10.7270/Q20R9N3T aid1800748 US8877775 Anderskewitz, R; Grauert, M; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138506 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138506&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90436468 249815731 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 272639 NC(=O)c1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2NC3CCC2CC3)C#N)cc1 InChI=1S/C24H26N4O2/c25-14-21(28-24(30)22-17-8-10-20(27-22)11-9-17)12-15-4-6-16(7-5-15)18-2-1-3-19(13-18)23(26)29/h1-7,13,17,20-22,27H,8-12H2,(H2,26,29)(H,28,30)/t17?,20?,21-,22-/m0/s1 DKVWNKVQQQEYMS-UIIOKCELSA-N 138507 US8877775, 18::US9073869, 18 Dipeptidyl peptidase 1 130.7 6 25.00 C US Patent 10.7270/Q20R9N3T aid1800748 US8877775 Anderskewitz, R; Grauert, M; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138507 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138507&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 86269543 249815732 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 272640 CN1C(=O)Cc2cc(ccc12)-c1ccc(C[C@H](NC(=O)[C@H]2NC3CCC2CC3)C#N)cc1 InChI=1S/C26H28N4O2/c1-30-23-11-8-19(13-20(23)14-24(30)31)17-4-2-16(3-5-17)12-22(15-27)29-26(32)25-18-6-9-21(28-25)10-7-18/h2-5,8,11,13,18,21-22,25,28H,6-7,9-10,12,14H2,1H3,(H,29,32)/t18?,21?,22-,25-/m0/s1 RFWWDMICQIKALN-OJDUGZSWSA-N 138508 US8877775, 19::US9073869, 19 Dipeptidyl peptidase 1 133.7 6 25.00 C US Patent 10.7270/Q20R9N3T aid1800748 US8877775 Anderskewitz, R; Grauert, M; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138508 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138508&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 86269544 249815733 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 272641 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2C(=O)NCCc2c1)C#N)[C@H]1NC2CCC1CC2 InChI=1S/C26H28N4O2/c27-15-22(30-26(32)24-18-5-8-21(29-24)9-6-18)13-16-1-3-17(4-2-16)19-7-10-23-20(14-19)11-12-28-25(23)31/h1-4,7,10,14,18,21-22,24,29H,5-6,8-9,11-13H2,(H,28,31)(H,30,32)/t18?,21?,22-,24-/m0/s1 OMOFSGFVCFCCSO-YRTXYGLRSA-N 138509 US8877775, 20::US9073869, 20 Dipeptidyl peptidase 1 136.7 6 25.00 C US Patent 10.7270/Q20R9N3T aid1800748 US8877775 Anderskewitz, R; Grauert, M; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138509 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138509&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 86269745 249815734 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 272642 COCCN1C(=O)Cc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2NC3CCC2CC3)C#N)cc1 InChI=1S/C28H32N4O3/c1-35-13-12-32-25-15-21(6-7-22(25)16-26(32)33)19-4-2-18(3-5-19)14-24(17-29)31-28(34)27-20-8-10-23(30-27)11-9-20/h2-7,15,20,23-24,27,30H,8-14,16H2,1H3,(H,31,34)/t20?,23?,24-,27-/m0/s1 SDTGCFBYMNZZRM-IFBCOXBDSA-N 138510 US8877775, 21::US9073869, 21 Dipeptidyl peptidase 1 159.8 6 25.00 C US Patent 10.7270/Q20R9N3T aid1800748 US8877775 Anderskewitz, R; Grauert, M; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138510 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138510&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90436377 249815735 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 272643 CCS(=O)(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2NC3CCC2CC3)C#N)cc1 InChI=1S/C25H29N3O3S/c1-2-32(30,31)23-13-9-19(10-14-23)18-5-3-17(4-6-18)15-22(16-26)28-25(29)24-20-7-11-21(27-24)12-8-20/h3-6,9-10,13-14,20-22,24,27H,2,7-8,11-12,15H2,1H3,(H,28,29)/t20?,21?,22-,24-/m0/s1 VYCQXWJLCVEDQL-AELPEBTASA-N 138511 US8877775, 22::US9073869, 22 Dipeptidyl peptidase 1 164.4 6 25.00 C US Patent 10.7270/Q20R9N3T aid1800748 US8877775 Anderskewitz, R; Grauert, M; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138511 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138511&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 86269130 249815736 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 272644 Fc1cc(cc(F)c1F)-c1ccc(C[C@H](NC(=O)[C@H]2NC3CCC2CC3)C#N)cc1 InChI=1S/C23H22F3N3O/c24-19-10-16(11-20(25)21(19)26)14-3-1-13(2-4-14)9-18(12-27)29-23(30)22-15-5-7-17(28-22)8-6-15/h1-4,10-11,15,17-18,22,28H,5-9H2,(H,29,30)/t15?,17?,18-,22-/m0/s1 ASHCBEYYVNPBGG-DRHHIBKESA-N 138512 US8877775, 23::US9073869, 23 Dipeptidyl peptidase 1 243.7 6 25.00 C US Patent 10.7270/Q20R9N3T aid1800748 US8877775 Anderskewitz, R; Grauert, M; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138512 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138512&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 86269129 249815737 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 272645 O=C(N[C@@H](Cc1ccc(cc1)-c1ccnc(c1)C#N)C#N)[C@H]1NC2CCC1CC2 InChI=1S/C23H23N5O/c24-13-20-12-18(9-10-26-20)16-3-1-15(2-4-16)11-21(14-25)28-23(29)22-17-5-7-19(27-22)8-6-17/h1-4,9-10,12,17,19,21-22,27H,5-8,11H2,(H,28,29)/t17?,19?,21-,22-/m0/s1 BVGZFLVZIKBBIE-SUOYUTEQSA-N 138513 US8877775, 24::US9073869, 24 Dipeptidyl peptidase 1 248.5 6 25.00 C US Patent 10.7270/Q20R9N3T aid1800748 US8877775 Anderskewitz, R; Grauert, M; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138513 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138513&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 86269131 249815738 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 272646 CN1Cc2ccc(cc2C1)-c1ccc(C[C@H](NC(=O)[C@H]2NC3CCC2CC3)C#N)c(F)c1 InChI=1S/C26H29FN4O/c1-31-14-20-5-3-17(10-21(20)15-31)18-2-4-19(24(27)12-18)11-23(13-28)30-26(32)25-16-6-8-22(29-25)9-7-16/h2-5,10,12,16,22-23,25,29H,6-9,11,14-15H2,1H3,(H,30,32)/t16?,22?,23-,25-/m0/s1 MERRSYSCRGNVPA-RPPMGDBSSA-N 138514 US8877775, 25::US9073869, 25 Dipeptidyl peptidase 1 98 6 25.00 C US Patent 10.7270/Q20R9N3T aid1800748 US8877775 Anderskewitz, R; Grauert, M; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138514&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 86269132 249815739 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 272647 CS(=O)(=O)c1ccc(cc1C#N)-c1ccc(C[C@H](NC(=O)C2NC3CCC2CC3)C#N)c(F)c1 InChI=1S/C25H25FN4O3S/c1-34(32,33)23-9-6-16(10-19(23)13-27)17-2-3-18(22(26)12-17)11-21(14-28)30-25(31)24-15-4-7-20(29-24)8-5-15/h2-3,6,9-10,12,15,20-21,24,29H,4-5,7-8,11H2,1H3,(H,30,31)/t15?,20?,21-,24?/m0/s1 TXKVDXAWFGASKU-DQLVKDCISA-N 138515 US8877775, 26::US9073869, 26 Dipeptidyl peptidase 1 27.8 6 25.00 C US Patent 10.7270/Q20R9N3T aid1800748 US8877775 Anderskewitz, R; Grauert, M; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138515&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 78210289 249815740 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 272648 CN1Cc2cc(ccc2S1(=O)=O)-c1ccc(C[C@H](NC(=O)[C@H]2NC3CCC2CC3)C#N)c(F)c1 InChI=1S/C25H27FN4O3S/c1-30-14-19-10-16(6-9-23(19)34(30,32)33)17-2-3-18(22(26)12-17)11-21(13-27)29-25(31)24-15-4-7-20(28-24)8-5-15/h2-3,6,9-10,12,15,20-21,24,28H,4-5,7-8,11,14H2,1H3,(H,29,31)/t15?,20?,21-,24-/m0/s1 SVTGEWLDLCDWFZ-SKSZBOKFSA-N 138516 US8877775, 27::US9073869, 27 Dipeptidyl peptidase 1 73.3 6 25.00 C US Patent 10.7270/Q20R9N3T aid1800748 US8877775 Anderskewitz, R; Grauert, M; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138516 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138516&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90436479 249815741 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289979 CN1CCN(CC1)C(=O)c1cc(cs1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C26H30FN5O2S/c1-31-6-8-32(9-7-31)26(34)23-13-19(15-35-23)16-2-3-17(22(27)12-16)10-21(14-28)30-25(33)24-18-4-5-20(11-18)29-24/h2-3,12-13,15,18,20-21,24,29H,4-11H2,1H3,(H,30,33)/t18-,20+,21-,24-/m0/s1 NGMZWVPZCPOOFW-UQWVPHONSA-N 150551 US10238633, Example 225::US8987249, 225::US9713606, 225 Dipeptidyl peptidase 1 0.8 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150551 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150551&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443275 252824802 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289980 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1csc(c1)C(=O)N1CCn2nccc2C1 InChI=1S/C27H27FN6O2S/c28-23-11-16(19-12-24(37-15-19)27(36)33-7-8-34-22(14-33)5-6-30-34)1-2-17(23)9-21(13-29)32-26(35)25-18-3-4-20(10-18)31-25/h1-2,5-6,11-12,15,18,20-21,25,31H,3-4,7-10,14H2,(H,32,35)/t18-,20+,21-,25-/m0/s1 YQNUZNHUSHDGSJ-HOSCZWGSSA-N 150552 US10238633, Example 226::US8987249, 226::US9713606, 226 Dipeptidyl peptidase 1 0.9 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150552&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443271 252824803 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289981 CC(C)N1CCN(CC1)C(=O)c1cc(cs1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C28H34FN5O2S/c1-17(2)33-7-9-34(10-8-33)28(36)25-14-21(16-37-25)18-3-4-19(24(29)13-18)11-23(15-30)32-27(35)26-20-5-6-22(12-20)31-26/h3-4,13-14,16-17,20,22-23,26,31H,5-12H2,1-2H3,(H,32,35)/t20-,22+,23-,26-/m0/s1 AAGFQGZDVAUKDA-VBZBYZBJSA-N 150553 US10238633, Example 227::US8987249, 227::US9713606, 227 Dipeptidyl peptidase 1 1 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150553 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150553&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443243 252824804 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289982 COCCN1CCN(CC1)C(=O)c1cc(cs1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C28H34FN5O3S/c1-37-11-10-33-6-8-34(9-7-33)28(36)25-15-21(17-38-25)18-2-3-19(24(29)14-18)12-23(16-30)32-27(35)26-20-4-5-22(13-20)31-26/h2-3,14-15,17,20,22-23,26,31H,4-13H2,1H3,(H,32,35)/t20-,22+,23-,26-/m0/s1 NMBMMMBGRONBTI-VBZBYZBJSA-N 150554 US10238633, Example 228::US8987249, 228::US9713606, 228 Dipeptidyl peptidase 1 1.6 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150554 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150554&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430442 252824805 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289983 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1csc(c1)C(=O)N1CCN(CC1)C1CC1 InChI=1S/C28H32FN5O2S/c29-24-13-17(20-14-25(37-16-20)28(36)34-9-7-33(8-10-34)23-5-6-23)1-2-18(24)11-22(15-30)32-27(35)26-19-3-4-21(12-19)31-26/h1-2,13-14,16,19,21-23,26,31H,3-12H2,(H,32,35)/t19-,21+,22-,26-/m0/s1 AJZSFQXBXRWQNH-IYCJUYGXSA-N 150555 US10238633, Example 229::US8987249, 229::US9713606, 229 Dipeptidyl peptidase 1 1.7 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150555&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443161 252824806 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289984 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1csc(c1)C(=O)N1CCOCC1 InChI=1S/C25H27FN4O3S/c26-21-11-15(18-12-22(34-14-18)25(32)30-5-7-33-8-6-30)1-2-16(21)9-20(13-27)29-24(31)23-17-3-4-19(10-17)28-23/h1-2,11-12,14,17,19-20,23,28H,3-10H2,(H,29,31)/t17-,19+,20-,23-/m0/s1 GNRZSULABSHVGF-USKVXJDGSA-N 150556 US10238633, Example 230::US8987249, 230::US9713606, 230 Dipeptidyl peptidase 1 1.8 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150556 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150556&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430671 252824807 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289985 CC(=O)N1CCN(CC1)C(=O)c1cc(cs1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C27H30FN5O3S/c1-16(34)32-6-8-33(9-7-32)27(36)24-13-20(15-37-24)17-2-3-18(23(28)12-17)10-22(14-29)31-26(35)25-19-4-5-21(11-19)30-25/h2-3,12-13,15,19,21-22,25,30H,4-11H2,1H3,(H,31,35)/t19-,21+,22-,25-/m0/s1 LJOIAAPUDIPGIQ-RBODFLQRSA-N 150557 US10238633, Example 231::US8987249, 231::US9713606, 231 Dipeptidyl peptidase 1 2.2 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150557 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150557&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443159 252824808 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289986 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1csc(c1)C(=O)N1CCN(CC(F)(F)F)CC1 InChI=1S/C27H29F4N5O2S/c28-22-11-16(1-2-17(22)9-21(13-32)34-25(37)24-18-3-4-20(10-18)33-24)19-12-23(39-14-19)26(38)36-7-5-35(6-8-36)15-27(29,30)31/h1-2,11-12,14,18,20-21,24,33H,3-10,15H2,(H,34,37)/t18-,20+,21-,24-/m0/s1 ZKDHZVVYLAZZBU-UQWVPHONSA-N 150558 US10238633, Example 232::US8987249, 232::US9713606, 232 Dipeptidyl peptidase 1 2.2 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150558&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443163 252824809 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289987 CN1CCN(CC1=O)C(=O)c1cc(cs1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C26H28FN5O3S/c1-31-6-7-32(13-23(31)33)26(35)22-11-18(14-36-22)15-2-3-16(21(27)10-15)8-20(12-28)30-25(34)24-17-4-5-19(9-17)29-24/h2-3,10-11,14,17,19-20,24,29H,4-9,13H2,1H3,(H,30,34)/t17-,19+,20-,24-/m0/s1 GZYHERLOGHRBJT-GHCZAOPSSA-N 150559 US10238633, Example 233::US8987249, 233::US9713606, 233 Dipeptidyl peptidase 1 2.2 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150559 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150559&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430672 252824810 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289988 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1csc(c1)C(=O)N1CCN2CCOCC2C1 InChI=1S/C28H32FN5O3S/c29-24-11-17(1-2-18(24)9-22(13-30)32-27(35)26-19-3-4-21(10-19)31-26)20-12-25(38-16-20)28(36)34-6-5-33-7-8-37-15-23(33)14-34/h1-2,11-12,16,19,21-23,26,31H,3-10,14-15H2,(H,32,35)/t19-,21+,22-,23?,26-/m0/s1 LZNDHEGNLIOHKM-RMDYTIRNSA-N 150560 US10238633, Example 234::US8987249, 234::US9713606, 234 Dipeptidyl peptidase 1 3.8 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150560&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443274 252824811 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289989 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1csc(c1)C(=O)NC1CCOCC1 InChI=1S/C26H29FN4O3S/c27-22-11-15(18-12-23(35-14-18)25(32)30-19-5-7-34-8-6-19)1-2-16(22)9-21(13-28)31-26(33)24-17-3-4-20(10-17)29-24/h1-2,11-12,14,17,19-21,24,29H,3-10H2,(H,30,32)(H,31,33)/t17-,20+,21-,24-/m0/s1 UPLHVYVHWWQDBR-QELHCHSZSA-N 150561 US10238633, Example 235::US8987249, 235::US9713606, 235 Dipeptidyl peptidase 1 4.7 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150561 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150561&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430386 252824812 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289990 NC(=O)c1ccc(s1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H21FN4O2S/c22-16-9-12(17-5-6-18(29-17)20(24)27)2-1-11(16)7-15(10-23)26-21(28)19-13-3-4-14(8-13)25-19/h1-2,5-6,9,13-15,19,25H,3-4,7-8H2,(H2,24,27)(H,26,28)/t13-,14+,15-,19-/m0/s1 DNXDSWIEQRGCDX-YGTYGHESSA-N 150562 US10238633, Example 236::US8987249, 236::US9713606, 236 Dipeptidyl peptidase 1 1.6 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150562 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150562&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430394 252824813 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289991 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc(s1)C(=O)N1CCn2nccc2C1 InChI=1S/C27H27FN6O2S/c28-22-13-17(23-5-6-24(37-23)27(36)33-9-10-34-21(15-33)7-8-30-34)2-1-16(22)11-20(14-29)32-26(35)25-18-3-4-19(12-18)31-25/h1-2,5-8,13,18-20,25,31H,3-4,9-12,15H2,(H,32,35)/t18-,19+,20-,25-/m0/s1 DRMBHMUJYOWYMG-ZDQHKECQSA-N 150563 US10238633, Example 237::US8987249, 237::US9713606, 237 Dipeptidyl peptidase 1 4.6 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150563 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150563&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430395 252824814 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289992 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc(o1)C(=O)N1CCN2CCOCC2C1 InChI=1S/C28H32FN5O4/c29-23-13-18(2-1-17(23)11-21(14-30)32-27(35)26-19-3-4-20(12-19)31-26)24-5-6-25(38-24)28(36)34-8-7-33-9-10-37-16-22(33)15-34/h1-2,5-6,13,19-22,26,31H,3-4,7-12,15-16H2,(H,32,35)/t19-,20+,21-,22?,26-/m0/s1 JEOANMFZMPFLAU-QJCBJTJFSA-N 150564 US10238633, Example 238::US8987249, 238::US9713606, 238 Dipeptidyl peptidase 1 14.3 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150564&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443164 252824815 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289993 NC(=O)c1coc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H21FN4O3/c22-17-7-12(18-8-14(10-29-18)20(24)27)2-1-11(17)5-16(9-23)26-21(28)19-13-3-4-15(6-13)25-19/h1-2,7-8,10,13,15-16,19,25H,3-6H2,(H2,24,27)(H,26,28)/t13-,15+,16-,19-/m0/s1 AIYPJVNZGWXDOA-YBKUAAOGSA-N 150565 US10238633, Example 239::US8987249, 239::US9713606, 239 Dipeptidyl peptidase 1 3.4 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150565 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150565&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430357 252824816 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289994 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cc(co1)C(=O)N1CCn2nccc2C1 InChI=1S/C27H27FN6O3/c28-23-11-17(24-12-19(15-37-24)27(36)33-7-8-34-22(14-33)5-6-30-34)2-1-16(23)9-21(13-29)32-26(35)25-18-3-4-20(10-18)31-25/h1-2,5-6,11-12,15,18,20-21,25,31H,3-4,7-10,14H2,(H,32,35)/t18-,20+,21-,25-/m0/s1 OZZMJNAGINALHX-HOSCZWGSSA-N 150566 US8987249, 240::US9713606, 240 Dipeptidyl peptidase 1 6.1 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150566 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150566&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443256 252824817 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289995 CN1CCN(CC1)C(=O)c1coc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C26H30FN5O3/c1-31-6-8-32(9-7-31)26(34)19-13-23(35-15-19)17-3-2-16(22(27)12-17)10-21(14-28)30-25(33)24-18-4-5-20(11-18)29-24/h2-3,12-13,15,18,20-21,24,29H,4-11H2,1H3,(H,30,33)/t18-,20+,21-,24-/m0/s1 LDLHLKGXKXFHRZ-UQWVPHONSA-N 150567 US10238633, Example 241::US8987249, 241::US9713606, 241 Dipeptidyl peptidase 1 6.8 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150567 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150567&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430227 252824818 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289996 CCNC(=O)c1coc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H25FN4O3/c1-2-26-22(29)16-10-20(31-12-16)14-4-3-13(19(24)9-14)7-18(11-25)28-23(30)21-15-5-6-17(8-15)27-21/h3-4,9-10,12,15,17-18,21,27H,2,5-8H2,1H3,(H,26,29)(H,28,30)/t15-,17+,18-,21-/m0/s1 VMZSCTQFZQDFOI-DKXUYOFUSA-N 150568 US10238633, Example 242::US8987249, 242::US9713606, 242 Dipeptidyl peptidase 1 10.9 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150568&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430247 252824819 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289997 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnn(c1)S(=O)(=O)c1ccccc1 InChI=1S/C25H24FN5O3S/c26-23-12-16(19-14-28-31(15-19)35(33,34)22-4-2-1-3-5-22)6-7-17(23)10-21(13-27)30-25(32)24-18-8-9-20(11-18)29-24/h1-7,12,14-15,18,20-21,24,29H,8-11H2,(H,30,32)/t18-,20+,21-,24-/m0/s1 QABZRGUXQDPQLL-UQWVPHONSA-N 150569 US10238633, Example 243::US8987249, 243::US9713606, 243 Dipeptidyl peptidase 1 4.8 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150569 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150569&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430207 252824820 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289998 NC(=O)c1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H23FN4O2/c24-20-11-14(13-2-1-3-17(8-13)22(26)29)4-5-15(20)9-19(12-25)28-23(30)21-16-6-7-18(10-16)27-21/h1-5,8,11,16,18-19,21,27H,6-7,9-10H2,(H2,26,29)(H,28,30)/t16-,18+,19-,21-/m0/s1 URKPBBPYGGQLCL-KRQVXIAISA-N 150570 US10238633, Example 244::US8987249, 244::US9713606, 244 Dipeptidyl peptidase 1 3.7 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150570 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150570&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430260 252824821 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289999 CN1CCN(CC1)C(=O)c1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C28H32FN5O2/c1-33-9-11-34(12-10-33)28(36)22-4-2-3-18(13-22)19-5-6-20(25(29)16-19)14-24(17-30)32-27(35)26-21-7-8-23(15-21)31-26/h2-6,13,16,21,23-24,26,31H,7-12,14-15H2,1H3,(H,32,35)/t21-,23+,24-,26-/m0/s1 VFHWVMMVSYURFG-YUZJIJRXSA-N 150571 US10238633, Example 245::US8987249, 245::US9713606, 245 Dipeptidyl peptidase 1 5.9 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150571 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150571&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443260 252824822 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290000 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc(cc1)S(=O)(=O)N1CCC(F)(F)CC1 InChI=1S/C27H29F3N4O3S/c28-24-15-18(17-4-7-23(8-5-17)38(36,37)34-11-9-27(29,30)10-12-34)1-2-19(24)13-22(16-31)33-26(35)25-20-3-6-21(14-20)32-25/h1-2,4-5,7-8,15,20-22,25,32H,3,6,9-14H2,(H,33,35)/t20-,21+,22-,25-/m0/s1 DMXKZSZRABVDLH-MTQWNXOMSA-N 150572 BDBM263819::US10238633, Example 246::US8987249, 246 Dipeptidyl peptidase 1 5.9 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150572 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150572&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430686 252824823 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290001 CN1CCCN(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H30FN5O/c1-27-7-2-8-28(10-9-27)19-6-4-15(20(23)13-19)11-18(14-24)26-22(29)21-16-3-5-17(12-16)25-21/h4,6,13,16-18,21,25H,2-3,5,7-12H2,1H3,(H,26,29)/t16-,17+,18-,21-/m0/s1 JUIRQFMPMAKJMC-NYUBLWNDSA-N 150573 US10238633, Example 247::US8987249, 247::US9713606, 247 Dipeptidyl peptidase 1 8.4 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150573 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150573&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430673 252824824 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290002 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCC2C(CCNC2=O)C1 InChI=1S/C24H30FN5O2/c25-21-11-19(30-8-6-20-16(13-30)5-7-27-23(20)31)4-2-14(21)9-18(12-26)29-24(32)22-15-1-3-17(10-15)28-22/h2,4,11,15-18,20,22,28H,1,3,5-10,13H2,(H,27,31)(H,29,32)/t15-,16?,17+,18-,20?,22-/m0/s1 PMZMGDBQXVWCAC-GAGFYFTPSA-N 150574 US10238633, Example 248::US8987249, 248::US9713606, 248 Dipeptidyl peptidase 1 18 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150574 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150574&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430639 252824825 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290003 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCN2CCOC[C@@H]2C1 InChI=1S/C23H30FN5O2/c24-21-11-19(29-6-5-28-7-8-31-14-20(28)13-29)4-2-15(21)9-18(12-25)27-23(30)22-16-1-3-17(10-16)26-22/h2,4,11,16-18,20,22,26H,1,3,5-10,13-14H2,(H,27,30)/t16-,17+,18-,20-,22-/m0/s1 SOLOVPGTCODBHF-FFUNNMLOSA-N 150575 US10238633, Example 249::US8987249, 249::US9713606, 249 Dipeptidyl peptidase 1 6.3 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150575&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430827 252824826 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290004 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCN2CCOC[C@H]2C1 InChI=1S/C23H30FN5O2/c24-21-11-19(29-6-5-28-7-8-31-14-20(28)13-29)4-2-15(21)9-18(12-25)27-23(30)22-16-1-3-17(10-16)26-22/h2,4,11,16-18,20,22,26H,1,3,5-10,13-14H2,(H,27,30)/t16-,17+,18-,20+,22-/m0/s1 SOLOVPGTCODBHF-JAZLEBMFSA-N 150576 US10238633, Example 250::US8987249, 250::US9713606, 250 Dipeptidyl peptidase 1 4.2 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150576 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150576&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430699 252824827 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290005 CC(C)C1CC(CCC1S(C)=O)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C26H36FN3O2S/c1-15(2)22-12-16(7-9-24(22)33(3)32)17-4-5-18(23(27)13-17)10-21(14-28)30-26(31)25-19-6-8-20(11-19)29-25/h4-5,13,15-16,19-22,24-25,29H,6-12H2,1-3H3,(H,30,31)/t16?,19-,20+,21-,22?,24?,25-,33?/m0/s1 RSIKUUKVZBOISV-FMMBUAGISA-N 150577 US8987249, 251 Dipeptidyl peptidase 1 11.5 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150577 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150577&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443272 252824828 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290006 CS(=O)(=O)c1ccc(cc1OCC(F)F)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C25H26F3N3O4S/c1-36(33,34)22-7-5-15(11-21(22)35-13-23(27)28)14-2-3-16(20(26)10-14)8-19(12-29)31-25(32)24-17-4-6-18(9-17)30-24/h2-3,5,7,10-11,17-19,23-24,30H,4,6,8-9,13H2,1H3,(H,31,32)/t17-,18+,19-,24-/m0/s1 FJAZHJZGIXPLOY-YDLHNXBPSA-N 150578 US10238633, Example 252::US8987249, 252::US9713606, 252 Dipeptidyl peptidase 1 3.8 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150578&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430228 252824829 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290007 CNc1nc2cc(ccc2n1C)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C25H27FN6O/c1-28-25-31-21-12-15(6-8-22(21)32(25)2)14-3-4-16(20(26)11-14)9-19(13-27)30-24(33)23-17-5-7-18(10-17)29-23/h3-4,6,8,11-12,17-19,23,29H,5,7,9-10H2,1-2H3,(H,28,31)(H,30,33)/t17-,18+,19-,23-/m0/s1 VPLUWXLMJBCMPZ-YWNPBTLJSA-N 150579 US10238633, Example 253::US8987249, 253::US9713606, 253 Dipeptidyl peptidase 1 11 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150579&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443262 252824830 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290008 Cn1cc(ccc1=O)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H23FN4O2/c1-27-12-16(5-7-20(27)28)13-2-3-14(19(23)10-13)8-18(11-24)26-22(29)21-15-4-6-17(9-15)25-21/h2-3,5,7,10,12,15,17-18,21,25H,4,6,8-9H2,1H3,(H,26,29)/t15-,17+,18-,21-/m0/s1 DVAYQWABFZKMAR-DKXUYOFUSA-N 150580 US10238633, Example 254::US8987249, 254::US9713606, 254 Dipeptidyl peptidase 1 2 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150580 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150580&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430261 252824831 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290009 Cn1ccc(cc1=O)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H23FN4O2/c1-27-7-6-14(11-20(27)28)13-2-3-15(19(23)10-13)8-18(12-24)26-22(29)21-16-4-5-17(9-16)25-21/h2-3,6-7,10-11,16-18,21,25H,4-5,8-9H2,1H3,(H,26,29)/t16-,17+,18-,21-/m0/s1 ACSGJNZSMAZGRN-NYUBLWNDSA-N 150581 US10238633, Example 255::US8987249, 255::US9713606, 255 Dipeptidyl peptidase 1 10.9 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150581 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150581&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430262 252824832 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290010 CN(C)CCn1ccc(cc1=O)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C25H30FN5O2/c1-30(2)9-10-31-8-7-17(14-23(31)32)16-3-4-18(22(26)13-16)11-21(15-27)29-25(33)24-19-5-6-20(12-19)28-24/h3-4,7-8,13-14,19-21,24,28H,5-6,9-12H2,1-2H3,(H,29,33)/t19-,20+,21-,24-/m0/s1 YVLKOTSUWUCUKO-XARGGIHNSA-N 150582 US10238633, Example 256::US8987249, 256::US9713606, 256 Dipeptidyl peptidase 1 26.3 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150582 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150582&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430844 252824833 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290011 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cc[nH]c(=O)c1 150583 US10238633, Example 257::US8987249, 257::US9713606, 257 Dipeptidyl peptidase 1 39.9 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150583 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150583&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937200 252824834 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290012 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc(=O)[nH]c1 150584 US10238633, Example 258::US8987249, 258::US9713606, 258 Dipeptidyl peptidase 1 7.9 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150584 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150584&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 127053696 252824835 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290013 CS(C)(=O)=Nc1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H27FN4O2S/c1-32(2,31)29-20-5-3-4-15(10-20)16-6-7-17(22(25)13-16)11-21(14-26)28-24(30)23-18-8-9-19(12-18)27-23/h3-7,10,13,18-19,21,23,27H,8-9,11-12H2,1-2H3,(H,28,30)/t18-,19+,21-,23-/m0/s1 IUJZTLDIIDKLJO-QRICJDHISA-N 150585 US10238633, Example 259::US8987249, 259::US9713606, 259 Dipeptidyl peptidase 1 6 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150585 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150585&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430810 252824836 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290014 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnn(C[C@H]2CCCO2)c1 InChI=1S/C24H28FN5O2/c25-22-10-15(18-12-27-30(13-18)14-21-2-1-7-32-21)3-4-16(22)8-20(11-26)29-24(31)23-17-5-6-19(9-17)28-23/h3-4,10,12-13,17,19-21,23,28H,1-2,5-9,14H2,(H,29,31)/t17-,19+,20-,21+,23-/m0/s1 HMZMPMLDAMDPBI-YMBXHIRXSA-N 150586 US10238633, Example 260::US8987249, 260::US9713606, 260 Dipeptidyl peptidase 1 3.5 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150586 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150586&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430801 252824837 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290015 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnn(C[C@@H]2CCCO2)c1 InChI=1S/C24H28FN5O2/c25-22-10-15(18-12-27-30(13-18)14-21-2-1-7-32-21)3-4-16(22)8-20(11-26)29-24(31)23-17-5-6-19(9-17)28-23/h3-4,10,12-13,17,19-21,23,28H,1-2,5-9,14H2,(H,29,31)/t17-,19+,20-,21-,23-/m0/s1 HMZMPMLDAMDPBI-NROJZILJSA-N 150587 US10238633, Example 261::US8987249, 261::US9713606, 261 Dipeptidyl peptidase 1 4.2 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150587 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150587&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430756 252824838 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290016 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnn(C[C@@H]2CCOC2)c1 InChI=1S/C24H28FN5O2/c25-22-9-16(19-11-27-30(13-19)12-15-5-6-32-14-15)1-2-17(22)7-21(10-26)29-24(31)23-18-3-4-20(8-18)28-23/h1-2,9,11,13,15,18,20-21,23,28H,3-8,12,14H2,(H,29,31)/t15-,18-,20+,21-,23-/m0/s1 CWXBPKJABGXNSH-WNZZMIDNSA-N 150588 US10238633, Example 262::US8987249, 262::US9713606, 262 Dipeptidyl peptidase 1 6.4 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150588 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150588&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430757 252824839 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290017 CS(=O)(=NC#N)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H24FN5O2S/c1-33(32,28-14-27)21-8-5-15(6-9-21)16-2-3-17(22(25)12-16)10-20(13-26)30-24(31)23-18-4-7-19(11-18)29-23/h2-3,5-6,8-9,12,18-20,23,29H,4,7,10-11H2,1H3,(H,30,31)/t18-,19+,20-,23-,33?/m0/s1 JMXAQAKZQYJMRJ-PVEGDPQMSA-N 150589 US10238633, Example 263::US8987249, 263::US9713606, 263 Dipeptidyl peptidase 1 11.8 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150589&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430784 252824840 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290018 CS(=O)(=Nc1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1)C1CCOCC1 InChI=1S/C28H33FN4O3S/c1-37(35,25-9-11-36-12-10-25)33-23-4-2-3-18(13-23)19-5-6-20(26(29)16-19)14-24(17-30)32-28(34)27-21-7-8-22(15-21)31-27/h2-6,13,16,21-22,24-25,27,31H,7-12,14-15H2,1H3,(H,32,34)/t21-,22+,24-,27-,37?/m0/s1 OJKBVCYANOMNAF-JOPHUIKPSA-N 150590 US10238633, Example 264::US8987249, 264::US9713606, 264 Dipeptidyl peptidase 1 17 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150590 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150590&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430866 252824841 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290019 CS(=O)c1cc(=O)n(cc1F)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H22F2N4O3S/c1-32(31)19-9-20(29)28(11-18(19)24)16-5-3-12(17(23)8-16)6-15(10-25)27-22(30)21-13-2-4-14(7-13)26-21/h3,5,8-9,11,13-15,21,26H,2,4,6-7H2,1H3,(H,27,30)/t13-,14+,15-,21-,32?/m0/s1 CVPOOVIOJPARFP-LDEKDMLCSA-N 150591 US10238633, Example 265::US8987249, 265::US9713606, 265 Dipeptidyl peptidase 1 62.7 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150591 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150591&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430867 252824842 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290020 CS(=O)(=O)c1ccn(-c2ccc(C[C@H](NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)c(F)c2)c(=O)c1 InChI=1S/C22H23FN4O4S/c1-32(30,31)18-6-7-27(20(28)11-18)17-5-3-13(19(23)10-17)8-16(12-24)26-22(29)21-14-2-4-15(9-14)25-21/h3,5-7,10-11,14-16,21,25H,2,4,8-9H2,1H3,(H,26,29)/t14-,15+,16-,21-/m0/s1 KKPLONFOCYWZDO-YJXLLHPSSA-N 150592 US10238633, Example 266::US8987249, 266::US9713606, 266 Dipeptidyl peptidase 1 43.7 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150592 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150592&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430406 252824843 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290021 CC(C)N1CCCN(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H34FN5O/c1-16(2)29-8-3-9-30(11-10-29)21-7-5-17(22(25)14-21)12-20(15-26)28-24(31)23-18-4-6-19(13-18)27-23/h5,7,14,16,18-20,23,27H,3-4,6,8-13H2,1-2H3,(H,28,31)/t18-,19+,20-,23-/m0/s1 WFHYTCOTCREJLJ-SRYPRDQNSA-N 150593 US10238633, Example 267::US8987249, 267::US9713606, 267 Dipeptidyl peptidase 1 10.5 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150593 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150593&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430443 252824844 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290022 CC(C)(C)N1CCN(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H34FN5O/c1-24(2,3)30-10-8-29(9-11-30)20-7-5-16(21(25)14-20)12-19(15-26)28-23(31)22-17-4-6-18(13-17)27-22/h5,7,14,17-19,22,27H,4,6,8-13H2,1-3H3,(H,28,31)/t17-,18+,19-,22-/m0/s1 GZNWGNOSEGSJHK-WEMPKCCASA-N 150594 US10238633, Example 268::US8987249, 268::US9713606, 268 Dipeptidyl peptidase 1 11.1 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150594 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150594&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430444 252824845 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290023 CO[C@@H]1C[C@@H]2CN(CCN2C1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H32FN5O2/c1-32-21-10-20-13-29(6-7-30(20)14-21)19-5-3-15(22(25)11-19)8-18(12-26)28-24(31)23-16-2-4-17(9-16)27-23/h3,5,11,16-18,20-21,23,27H,2,4,6-10,13-14H2,1H3,(H,28,31)/t16-,17+,18-,20+,21+,23-/m0/s1 VIAZGHFEVYETOO-RWYQBMLRSA-N 150595 US10238633, Example 269::US8987249, 269::US9713606, 269 Dipeptidyl peptidase 1 9.4 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150595 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150595&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430423 252824846 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290024 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCN2CCC[C@H]2C1 InChI=1S/C23H30FN5O/c24-21-12-19(29-9-8-28-7-1-2-20(28)14-29)6-4-15(21)10-18(13-25)27-23(30)22-16-3-5-17(11-16)26-22/h4,6,12,16-18,20,22,26H,1-3,5,7-11,14H2,(H,27,30)/t16-,17+,18-,20-,22-/m0/s1 HLJGWEHAZHBPGN-FFUNNMLOSA-N 150596 US10238633, Example 270::US8987249, 270::US9713606, 270 Dipeptidyl peptidase 1 6.3 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150596 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150596&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430398 252824847 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290025 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCCN2CCCC2C1 InChI=1S/C24H32FN5O/c25-22-13-20(30-10-2-9-29-8-1-3-21(29)15-30)7-5-16(22)11-19(14-26)28-24(31)23-17-4-6-18(12-17)27-23/h5,7,13,17-19,21,23,27H,1-4,6,8-12,15H2,(H,28,31)/t17-,18+,19-,21?,23-/m0/s1 LEQJDFRTVFEHSE-BRJVMOAUSA-N 150597 US10238633, Example 271::US8987249, 271::US9713606, 271 Dipeptidyl peptidase 1 5.9 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150597&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430445 252824848 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290026 CCN1CCN(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H30FN5O/c1-2-27-7-9-28(10-8-27)19-6-4-15(20(23)13-19)11-18(14-24)26-22(29)21-16-3-5-17(12-16)25-21/h4,6,13,16-18,21,25H,2-3,5,7-12H2,1H3,(H,26,29)/t16-,17+,18-,21-/m0/s1 OQJKHSTWNPGKCN-NYUBLWNDSA-N 150598 US10238633, Example 272::US8987249, 272::US9713606, 272 Dipeptidyl peptidase 1 6.8 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150598&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430648 252824849 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290027 CCc1cc(nn1CC(C)C)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C25H32FN5O/c1-4-21-12-23(30-31(21)14-15(2)3)17-6-5-16(22(26)11-17)9-20(13-27)29-25(32)24-18-7-8-19(10-18)28-24/h5-6,11-12,15,18-20,24,28H,4,7-10,14H2,1-3H3,(H,29,32)/t18-,19+,20-,24-/m0/s1 QKCJEPXSJFAOTH-VKDGWMQASA-N 150599 US10238633, Example 273::US8987249, 273::US9713606, 273 Dipeptidyl peptidase 1 28.9 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150599 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150599&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430659 252824850 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290028 CS(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H24FN3O2S/c1-30(29)20-8-5-14(6-9-20)15-2-3-16(21(24)12-15)10-19(13-25)27-23(28)22-17-4-7-18(11-17)26-22/h2-3,5-6,8-9,12,17-19,22,26H,4,7,10-11H2,1H3,(H,27,28)/t17-,18+,19-,22-,30?/m0/s1 SDOAKBZNSFVUJC-NVFJITABSA-N 150600 US10238633, Example 274::US8987249, 274::US9713606, 274 Dipeptidyl peptidase 1 6.5 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150600 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150600&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430661 252824851 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290029 CCOc1cc(cc(c1)S(C)(=O)=O)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C25H28FN3O4S/c1-3-33-21-10-18(11-22(13-21)34(2,31)32)15-4-5-16(23(26)12-15)8-20(14-27)29-25(30)24-17-6-7-19(9-17)28-24/h4-5,10-13,17,19-20,24,28H,3,6-9H2,1-2H3,(H,29,30)/t17-,19+,20-,24-/m0/s1 YXBZSIUIDAWIIE-GHCZAOPSSA-N 150601 US10238633, Example 275::US8987249, 275::US9713606, 275 Dipeptidyl peptidase 1 33 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150601 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150601&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430649 252824852 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290030 CS(=O)(=O)c1cc(OCC(F)(F)F)cc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C25H25F4N3O4S/c1-37(34,35)21-9-17(8-20(11-21)36-13-25(27,28)29)14-2-3-15(22(26)10-14)6-19(12-30)32-24(33)23-16-4-5-18(7-16)31-23/h2-3,8-11,16,18-19,23,31H,4-7,13H2,1H3,(H,32,33)/t16-,18+,19-,23-/m0/s1 NOGUIGWOYFVCHA-FAODYONGSA-N 150602 US10238633, Example 276::US8987249, 276::US9713606, 276 Dipeptidyl peptidase 1 14.1 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150602&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430821 252824853 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290031 CN(C)CCCN1C(=O)Cc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C29H34FN5O2/c1-34(2)10-3-11-35-26-15-19(5-7-21(26)16-27(35)36)18-4-6-20(25(30)14-18)12-24(17-31)33-29(37)28-22-8-9-23(13-22)32-28/h4-7,14-15,22-24,28,32H,3,8-13,16H2,1-2H3,(H,33,37)/t22-,23+,24-,28-/m0/s1 XVWGIESADAKPIF-IMBSWCNGSA-N 150603 US10238633, Example 277::US8987249, 277::US9713606, 277 Dipeptidyl peptidase 1 3 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150603 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150603&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443263 252824854 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290032 CN(C)CCN1C(=O)Cc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C28H32FN5O2/c1-33(2)9-10-34-25-14-18(4-6-20(25)15-26(34)35)17-3-5-19(24(29)13-17)11-23(16-30)32-28(36)27-21-7-8-22(12-21)31-27/h3-6,13-14,21-23,27,31H,7-12,15H2,1-2H3,(H,32,36)/t21-,22+,23-,27-/m0/s1 AWNMFDZAZNAOSJ-GIRPNKPCSA-N 150604 US10238633, Example 278::US8987249, 278::US9713606, 278 Dipeptidyl peptidase 1 1 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150604 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150604&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430474 252824855 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290033 CN(C)CCN1C(=O)Cc2cc(ccc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C28H32FN5O2/c1-33(2)9-10-34-25-8-6-17(11-21(25)15-26(34)35)18-3-4-19(24(29)14-18)12-23(16-30)32-28(36)27-20-5-7-22(13-20)31-27/h3-4,6,8,11,14,20,22-23,27,31H,5,7,9-10,12-13,15H2,1-2H3,(H,32,36)/t20-,22+,23-,27-/m0/s1 NPDKQIXUJNALPW-XUTUTRJZSA-N 150605 US10238633, Example 279::US8987249, 279::US9713606, 279 Dipeptidyl peptidase 1 5.5 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150605 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150605&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430478 252824856 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290034 CC(C)N1CCC(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H33FN4O/c1-15(2)29-9-7-16(8-10-29)17-3-4-18(22(25)13-17)11-21(14-26)28-24(30)23-19-5-6-20(12-19)27-23/h3-4,13,15-16,19-21,23,27H,5-12H2,1-2H3,(H,28,30)/t19-,20+,21-,23-/m0/s1 VJGDLRYVNAZRGF-KGSLCBSSSA-N 150606 US10238633, Example 280::US8987249, 280::US9713606, 280 Dipeptidyl peptidase 1 21.2 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150606 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150606&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430473 252824857 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290035 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)C1=CCN2CCOCC2C1 InChI=1S/C24H29FN4O2/c25-22-12-15(16-5-6-29-7-8-31-14-21(29)11-16)1-2-17(22)9-20(13-26)28-24(30)23-18-3-4-19(10-18)27-23/h1-2,5,12,18-21,23,27H,3-4,6-11,14H2,(H,28,30)/t18-,19+,20-,21?,23-/m0/s1 CMFKDMUAZSMZET-SIKKGAFYSA-N 150607 US10238633, Example 281::US8987249, 281::US9713606, 281 Dipeptidyl peptidase 1 3.3 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150607 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150607&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430479 252824858 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290036 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)C1=CC2COCCN2CC1 InChI=1S/C24H29FN4O2/c25-22-12-15(16-5-6-29-7-8-31-14-21(29)11-16)1-2-17(22)9-20(13-26)28-24(30)23-18-3-4-19(10-18)27-23/h1-2,11-12,18-21,23,27H,3-10,14H2,(H,28,30)/t18-,19+,20-,21?,23-/m0/s1 KYHQETISGYHVCF-SIKKGAFYSA-N 150608 US10238633, Example 282::US8987249, 282::US9713606, 282 Dipeptidyl peptidase 1 3.7 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150608&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430481 252824859 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290037 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)[C@@H]1CCN2CCOC[C@H]2C1 InChI=1S/C24H31FN4O2/c25-22-12-15(16-5-6-29-7-8-31-14-21(29)11-16)1-2-17(22)9-20(13-26)28-24(30)23-18-3-4-19(10-18)27-23/h1-2,12,16,18-21,23,27H,3-11,14H2,(H,28,30)/t16-,18+,19-,20+,21-,23+/m1/s1 UVMGBTLVJPDNFH-IXRJDROYSA-N 150609 US10238633, Example 283::US8987249, 283::US9713606, 283 Dipeptidyl peptidase 1 9.7 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150609 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150609&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430740 252824860 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290038 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)[C@H]1CCN2CCOC[C@H]2C1 InChI=1S/C24H31FN4O2/c25-22-12-15(16-5-6-29-7-8-31-14-21(29)11-16)1-2-17(22)9-20(13-26)28-24(30)23-18-3-4-19(10-18)27-23/h1-2,12,16,18-21,23,27H,3-11,14H2,(H,28,30)/t16-,18-,19+,20-,21+,23-/m0/s1 UVMGBTLVJPDNFH-LYAMXQPKSA-N 150610 US10238633, Example 284::US8987249, 284::US9713606, 284 Dipeptidyl peptidase 1 13.8 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150610 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150610&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430753 252824861 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290039 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-n1cc(cn1)C(F)(F)F InChI=1S/C20H19F4N5O/c21-17-7-16(29-10-13(9-26-29)20(22,23)24)4-2-11(17)5-15(8-25)28-19(30)18-12-1-3-14(6-12)27-18/h2,4,7,9-10,12,14-15,18,27H,1,3,5-6H2,(H,28,30)/t12-,14+,15-,18-/m0/s1 KLUIZDATHDMRJM-OGIUKLMXSA-N 150611 US10238633, Example 285::US8987249, 285::US9713606, 285 Dipeptidyl peptidase 1 9.3 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150611 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150611&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430861 252824862 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290040 CN(C)C(=O)c1cnn(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H25FN6O2/c1-28(2)22(31)15-11-25-29(12-15)18-6-4-13(19(23)9-18)7-17(10-24)27-21(30)20-14-3-5-16(8-14)26-20/h4,6,9,11-12,14,16-17,20,26H,3,5,7-8H2,1-2H3,(H,27,30)/t14-,16+,17-,20-/m0/s1 ADLODPBTXCWQIJ-FORWCCJISA-N 150612 US10238633, Example 286::US8987249, 286::US9713606, 286 Dipeptidyl peptidase 1 38.9 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150612 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150612&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430862 252824863 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290041 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-n1cc(cn1)C(=O)N1CCOCC1 InChI=1S/C24H27FN6O3/c25-21-11-20(31-14-17(13-27-31)24(33)30-5-7-34-8-6-30)4-2-15(21)9-19(12-26)29-23(32)22-16-1-3-18(10-16)28-22/h2,4,11,13-14,16,18-19,22,28H,1,3,5-10H2,(H,29,32)/t16-,18+,19-,22-/m0/s1 PUDLCFJOVIUEHT-ZBPHCFQXSA-N 150613 US10238633, Example 287::US8987249, 287::US9713606, 287 Dipeptidyl peptidase 1 39.7 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150613 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150613&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430863 252824864 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290042 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc(o1)C(=O)N1CCOCC1 InChI=1S/C25H27FN4O4/c26-20-13-16(21-5-6-22(34-21)25(32)30-7-9-33-10-8-30)2-1-15(20)11-19(14-27)29-24(31)23-17-3-4-18(12-17)28-23/h1-2,5-6,13,17-19,23,28H,3-4,7-12H2,(H,29,31)/t17-,18+,19-,23-/m0/s1 QLIQIELZFMSNMZ-YWNPBTLJSA-N 150614 US10238633, Example 288::US8987249, 288::US9713606, 288 Dipeptidyl peptidase 1 2.3 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150614 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150614&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430829 252824865 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290043 CN1CCN(CC1)C(=O)c1ccc(o1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C26H30FN5O3/c1-31-8-10-32(11-9-31)26(34)23-7-6-22(35-23)17-3-2-16(21(27)14-17)12-20(15-28)30-25(33)24-18-4-5-19(13-18)29-24/h2-3,6-7,14,18-20,24,29H,4-5,8-13H2,1H3,(H,30,33)/t18-,19+,20-,24-/m0/s1 WONAWGLRVBZQLT-VKDGWMQASA-N 150615 US10238633, Example 289::US8987249, 289::US9713606, 289 Dipeptidyl peptidase 1 2.5 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150615 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150615&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443284 252824866 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290044 Fc1cc(OCc2ccccc2)ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N InChI=1S/C23H24FN3O2/c24-21-12-20(29-14-15-4-2-1-3-5-15)9-7-16(21)10-19(13-25)27-23(28)22-17-6-8-18(11-17)26-22/h1-5,7,9,12,17-19,22,26H,6,8,10-11,14H2,(H,27,28)/t17-,18+,19-,22-/m0/s1 ODYJNVQNAFLEJI-WEMPKCCASA-N 150616 US10238633, Example 290::US8987249, 290::US9713606, 290 Dipeptidyl peptidase 1 20.6 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150616 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150616&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430850 252824867 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290045 NC(=O)c1cc(F)c2[nH]c(=O)c3cc(CC(NC(=O)[C@H]4N[C@@H]5CC[C@H]4C5)C#N)ccc3c2c1 150617 US10238633, Example 291::US8987249, 291::US9713606, 291 Dipeptidyl peptidase 1 5.9 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150617&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937201 252824868 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290046 Fc1cc2c3ccc(cc3[nH]c(=O)c2cc1CC(NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)C#N 150618 US10238633, Example 292::US8987249, 292::US9713606, 292 Dipeptidyl peptidase 1 0.9 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150618 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150618&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937202 252824869 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290047 Fc1ccc2c(c1)[nH]c(=O)c1cc(CC(NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)c(F)cc21 150619 US10238633, Example 293::US8987249, 293::US9713606, 293 Dipeptidyl peptidase 1 1.3 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150619 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150619&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937203 252824870 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290048 Fc1cc2c3ccccc3[nH]c(=O)c2cc1CC(NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N 150620 US10238633, Example 294::US8987249, 294::US9713606, 294 Dipeptidyl peptidase 1 1.6 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150620&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937204 252824871 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290049 Fc1ccc2[nH]c(=O)c3cc(CC(NC(=O)[C@H]4N[C@@H]5CC[C@H]4C5)C#N)c(F)cc3c2c1 150621 US10238633, Example 295::US8987249, 295::US9713606, 295 Dipeptidyl peptidase 1 2.1 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150621&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937205 252824872 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290050 Fc1cc2c3ccc(CC(NC(=O)[C@H]4N[C@@H]5CC[C@H]4C5)C#N)cc3c(=O)[nH]c2c(F)c1F 150622 US10238633, Example 296::US8987249, 296::US9713606, 296 Dipeptidyl peptidase 1 2.9 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150622&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937206 252824873 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290051 Clc1ccc2c(c1)[nH]c(=O)c1cc(CC(NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)ccc21 150623 US10238633, Example 297::US8987249, 297::US9713606, 297 Dipeptidyl peptidase 1 3.2 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150623&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937207 252824874 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290052 O=C(NC(Cc1ccc2c3cc(ccc3[nH]c(=O)c2c1)C#N)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 150624 US10238633, Example 298::US8987249, 298::US9713606, 298 Dipeptidyl peptidase 1 3.2 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150624 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150624&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937208 252824875 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290053 COC(=O)c1ccc2[nH]c(=O)c3cc(CC(NC(=O)[C@H]4N[C@@H]5CC[C@H]4C5)C#N)ccc3c2c1 150625 US10238633, Example 299::US8987249, 299::US9713606, 299 Dipeptidyl peptidase 1 3.2 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150625&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937209 252824876 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290054 Fc1ccc2c3ccc(CC(NC(=O)[C@H]4N[C@@H]5CC[C@H]4C5)C#N)cc3c(=O)[nH]c2c1F 150626 US10238633, Example 300::US8987249, 300::US9713606, 300 Dipeptidyl peptidase 1 3.8 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150626&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937210 252824877 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290055 FC(F)(F)c1ccc2c(c1)[nH]c(=O)c1cc(C[C@H](NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)ccc21 150627 US10238633, Example 301::US8987249, 301::US9713606, 301 Dipeptidyl peptidase 1 4.5 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150627 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150627&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937211 252824878 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290056 FC(F)(F)c1cc2[nH]c(=O)c3cc(CC(NC(=O)[C@H]4N[C@@H]5CC[C@H]4C5)C#N)ccc3c2cc1C#N 150628 US10238633, Example 302::US8987249, 302::US9713606, 302 Dipeptidyl peptidase 1 4.7 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150628 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150628&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937212 252824879 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290057 Cn1c2cc(ccc2c2ccc(CC(NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)cc2c1=O)C#N InChI=1S/C25H23N5O2/c1-30-22-10-15(12-26)3-7-20(22)19-6-2-14(9-21(19)25(30)32)8-18(13-27)29-24(31)23-16-4-5-17(11-16)28-23/h2-3,6-7,9-10,16-18,23,28H,4-5,8,11H2,1H3,(H,29,31)/t16-,17+,18?,23-/m0/s1 JRJZXYNCCWJCKO-XDGMMDTHSA-N 150629 US10238633, Example 303::US8987249, 303::US9713606, 303 Dipeptidyl peptidase 1 5 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150629 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150629&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430280 252824880 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290058 Clc1ccc2[nH]c(=O)c3cc(CC(NC(=O)[C@H]4N[C@@H]5CC[C@H]4C5)C#N)ccc3c2c1 150630 US10238633, Example 304::US8987249, 304::US9713606, 304 Dipeptidyl peptidase 1 6 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150630 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150630&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937213 252824881 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290059 Cn1c2cc(Cl)ccc2c2ccc(CC(NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)cc2c1=O InChI=1S/C24H23ClN4O2/c1-29-21-11-15(25)4-7-19(21)18-6-2-13(9-20(18)24(29)31)8-17(12-26)28-23(30)22-14-3-5-16(10-14)27-22/h2,4,6-7,9,11,14,16-17,22,27H,3,5,8,10H2,1H3,(H,28,30)/t14-,16+,17?,22-/m0/s1 SVARUVQPDCVUTH-UHDBIXDDSA-N 150631 US10238633, Example 305::US8987249, 305::US9713606, 305 Dipeptidyl peptidase 1 6.9 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150631 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150631&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90415298 252824882 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290060 CNC(=O)Cc1ccc2[nH]c(=O)c3cc(CC(NC(=O)[C@H]4N[C@@H]5CC[C@H]4C5)C#N)ccc3c2c1 150632 US10238633, Example 306::US8987249, 306::US9713606, 306 Dipeptidyl peptidase 1 7 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150632 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150632&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937214 252824883 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290061 Fc1cc(cc2c3ccc(CC(NC(=O)[C@H]4N[C@@H]5CC[C@H]4C5)C#N)cc3c(=O)[nH]c12)C#N 150633 US10238633, Example 307::US8987249, 307::US9713606, 307 Dipeptidyl peptidase 1 7.2 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150633 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150633&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937215 252824884 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290062 Fc1cccc2c3ccc(CC(NC(=O)[C@H]4N[C@@H]5CC[C@H]4C5)C#N)cc3c(=O)[nH]c12 150634 US10238633, Example 308::US8987249, 308::US9713606, 308 Dipeptidyl peptidase 1 8.3 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150634 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150634&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937216 252824885 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290063 O=C(NC(Cc1ccc2c3ccc(cc3[nH]c(=O)c2c1)C#N)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 150635 US10238633, Example 309::US8987249, 309::US9713606, 309 Dipeptidyl peptidase 1 9.1 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150635 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150635&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937217 252824886 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290064 Fc1cc(F)c2[nH]c(=O)c3cc(CC(NC(=O)[C@H]4N[C@@H]5CC[C@H]4C5)C#N)ccc3c2c1 150636 US10238633, Example 310::US8987249, 310::US9713606, 310 Dipeptidyl peptidase 1 9.4 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150636 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150636&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937218 252824887 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290065 COC(=O)c1cccc2c1[nH]c(=O)c1cc(CC(NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)ccc21 150637 US10238633, Example 311::US8987249, 311::US9713606, 311 Dipeptidyl peptidase 1 9.9 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150637 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150637&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937219 252824888 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290066 COc1ccc2[nH]c(=O)c3cc(CC(NC(=O)[C@H]4N[C@@H]5CC[C@H]4C5)C#N)ccc3c2c1 150638 US10238633, Example 312::US8987249, 312::US9713606, 312 Dipeptidyl peptidase 1 11 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150638 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150638&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937220 252824889 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290067 CS(=O)(=O)c1ccc2[nH]c(=O)c3cc(CC(NC(=O)[C@H]4N[C@@H]5CC[C@H]4C5)C#N)ccc3c2c1 150639 US10238633, Example 313::US8987249, 313::US9713606, 313 Dipeptidyl peptidase 1 13.6 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150639 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150639&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937221 252824890 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290068 Nc1ccc2[nH]c(=O)c3cc(CC(NC(=O)[C@H]4N[C@@H]5CC[C@H]4C5)C#N)ccc3c2c1 150640 US10238633, Example 314::US8987249, 314::US9713606, 314 Dipeptidyl peptidase 1 14 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150640 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150640&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937222 252824891 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290069 Fc1ccc2c(c1)ncc1cc(CC(NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)ccc21 InChI=1S/C23H21FN4O/c24-16-3-6-20-19-5-1-13(7-15(19)12-26-21(20)10-16)8-18(11-25)28-23(29)22-14-2-4-17(9-14)27-22/h1,3,5-7,10,12,14,17-18,22,27H,2,4,8-9H2,(H,28,29)/t14-,17+,18?,22-/m0/s1 QJNLKABXJHEPTA-IHQHAJGLSA-N 150641 US10238633, Example 315::US8987249, 315::US9713606, 315 Dipeptidyl peptidase 1 13.5 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150641 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150641&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90414194 252824892 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290070 O=C(NC(Cc1ccc2c(cnc3ccccc23)c1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C23H22N4O/c24-12-18(27-23(28)22-15-6-7-17(11-15)26-22)10-14-5-8-19-16(9-14)13-25-21-4-2-1-3-20(19)21/h1-5,8-9,13,15,17-18,22,26H,6-7,10-11H2,(H,27,28)/t15-,17+,18?,22-/m0/s1 PKYHSYLOBVYURX-JJOTWVSXSA-N 150642 US10238633, Example 316::US8987249, 316::US9713606, 316 Dipeptidyl peptidase 1 42.4 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150642 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150642&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430270 252824893 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290071 Oc1cccc(n1)-c1ccc(F)c(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c1 InChI=1S/C21H21FN4O2/c22-17-7-5-12(18-2-1-3-19(27)26-18)8-14(17)10-16(11-23)25-21(28)20-13-4-6-15(9-13)24-20/h1-3,5,7-8,13,15-16,20,24H,4,6,9-10H2,(H,25,28)(H,26,27)/t13-,15+,16-,20-/m0/s1 IDXWFRRWRADIAT-YEOLMYPVSA-N 150643 US8987249, 317::US9713606, 317 Dipeptidyl peptidase 1 52 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150643 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150643&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430275 252824894 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290072 CN1CCN(CC1)c1ccc(F)c(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c1 InChI=1S/C21H28FN5O/c1-26-6-8-27(9-7-26)18-4-5-19(22)15(12-18)11-17(13-23)25-21(28)20-14-2-3-16(10-14)24-20/h4-5,12,14,16-17,20,24H,2-3,6-11H2,1H3,(H,25,28)/t14-,16+,17-,20-/m0/s1 YHGGOZOSHZJPNN-FORWCCJISA-N 150644 US10238633, Example 318::US8987249, 318::US9713606, 318 Dipeptidyl peptidase 1 212 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150644 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150644&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430269 252824895 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290073 CN1CCC(CC1)Oc1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H29FN4O2/c1-27-8-6-18(7-9-27)29-19-5-3-14(20(23)12-19)10-17(13-24)26-22(28)21-15-2-4-16(11-15)25-21/h3,5,12,15-18,21,25H,2,4,6-11H2,1H3,(H,26,28)/t15-,16+,17-,21-/m0/s1 HYUGWMVHDPXQBJ-DLRJPAPCSA-N 150645 US10238633, Example 319::US8987249, 319::US9713606, 319 Dipeptidyl peptidase 1 17.5 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150645 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150645&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90413630 252824896 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290074 CCN1CCC(=CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H29FN4O/c1-2-28-9-7-15(8-10-28)16-3-4-17(21(24)13-16)11-20(14-25)27-23(29)22-18-5-6-19(12-18)26-22/h3-4,7,13,18-20,22,26H,2,5-6,8-12H2,1H3,(H,27,29)/t18-,19+,20-,22-/m0/s1 OZZNAKFBQUXBQF-IIZPIQPGSA-N 150646 US10238633, Example 320::US8987249, 320::US9713606, 320 Dipeptidyl peptidase 1 9.6 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150646 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150646&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430274 252824897 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290075 CN1CCC(C)(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H31FN4O/c1-23(7-9-28(2)10-8-23)17-5-3-15(20(24)13-17)11-19(14-25)27-22(29)21-16-4-6-18(12-16)26-21/h3,5,13,16,18-19,21,26H,4,6-12H2,1-2H3,(H,27,29)/t16-,18+,19-,21-/m0/s1 WMXMRYCYIHGDFQ-KRQVXIAISA-N 150647 US10238633, Example 321::US8987249, 321::US9713606, 321 Dipeptidyl peptidase 1 56.8 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150647 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150647&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430259 252824898 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290076 Fc1cc2c3ccccc3[nH]c(=O)c2cc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N 150648 US10238633, Example 322::US8987249, 322::US9713606, 322 Dipeptidyl peptidase 1 0.8 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150648 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150648&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937223 252824899 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290077 Fc1ccc2c(c1)[nH]c(=O)c1cc(C[C@H](NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)c(F)cc21 150649 US10238633, Example 323::US8987249, 323::US9713606, 323 Dipeptidyl peptidase 1 0.8 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150649 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150649&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937224 252824900 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290078 Fc1ccc2c3cc(F)c(C[C@H](NC(=O)[C@H]4N[C@@H]5CC[C@H]4C5)C#N)cc3c(=O)[nH]c2c1F 150650 US10238633, Example 324::US8987249, 324::US9713606, 324 Dipeptidyl peptidase 1 1 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150650 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150650&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937225 252824901 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290079 Fc1cc2c3cc(cc(F)c3[nH]c(=O)c2cc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)C#N 150651 US10238633, Example 325::US8987249, 325::US9713606, 325 Dipeptidyl peptidase 1 1.3 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150651 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150651&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937226 252824902 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290080 Cn1c2ccccc2c2cc(F)c(C[C@H](NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)cc2c1=O InChI=1S/C24H23FN4O2/c1-29-21-5-3-2-4-17(21)18-11-20(25)14(10-19(18)24(29)31)9-16(12-26)28-23(30)22-13-6-7-15(8-13)27-22/h2-5,10-11,13,15-16,22,27H,6-9H2,1H3,(H,28,30)/t13-,15+,16-,22-/m0/s1 WKTMNQATQFDGDF-IZGSKCEXSA-N 150652 US10238633, Example 326::US8987249, 326::US9713606, 326 Dipeptidyl peptidase 1 1.9 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150652 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150652&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430268 252824903 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290081 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CC2(CNC2)C1 InChI=1S/C21H26FN5O/c22-18-7-17(27-11-21(12-27)9-24-10-21)4-2-13(18)5-16(8-23)26-20(28)19-14-1-3-15(6-14)25-19/h2,4,7,14-16,19,24-25H,1,3,5-6,9-12H2,(H,26,28)/t14-,15+,16-,19-/m0/s1 YUZUVEKDYNDTLN-RCJHGTSTSA-N 150653 US10238633, Example 327::US8987249, 327::US9713606, 327 Dipeptidyl peptidase 1 3.4 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150653 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150653&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430656 252824904 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290082 CN1CC2CCC(C1)N2c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H30FN5O/c1-28-12-19-6-7-20(13-28)29(19)18-5-3-14(21(24)10-18)8-17(11-25)27-23(30)22-15-2-4-16(9-15)26-22/h3,5,10,15-17,19-20,22,26H,2,4,6-9,12-13H2,1H3,(H,27,30)/t15-,16+,17-,19?,20?,22-/m0/s1 HTGIRCXAILFFBK-DVFPXELVSA-N 150654 US10238633, Example 328::US8987249, 328::US9713606, 328 Dipeptidyl peptidase 1 4.2 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150654&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430746 252824905 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290083 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1C2CCC1CN(C2)C1CCOC1 InChI=1S/C26H34FN5O2/c27-24-11-20(32-21-5-6-22(32)14-31(13-21)23-7-8-34-15-23)4-2-16(24)9-19(12-28)30-26(33)25-17-1-3-18(10-17)29-25/h2,4,11,17-19,21-23,25,29H,1,3,5-10,13-15H2,(H,30,33)/t17-,18+,19-,21?,22?,23?,25-/m0/s1 CFVCLDGBQIROEH-FHVJXWHLSA-N 150655 US10238633, Example 329::US8987249, 329::US9713606, 329 Dipeptidyl peptidase 1 7 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150655&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430697 252824906 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290084 CN1CC2(C1)CN(C2)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H28FN5O/c1-27-10-22(11-27)12-28(13-22)18-5-3-14(19(23)8-18)6-17(9-24)26-21(29)20-15-2-4-16(7-15)25-20/h3,5,8,15-17,20,25H,2,4,6-7,10-13H2,1H3,(H,26,29)/t15-,16+,17-,20-/m0/s1 GZROAMVDJTZDHV-CLWJZODNSA-N 150656 US10238633, Example 330::US8987249, 330::US9713606, 330 Dipeptidyl peptidase 1 7.8 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150656 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150656&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430645 252824907 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290085 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCN(CC1)C1CCOC1 InChI=1S/C24H32FN5O2/c25-22-13-20(29-6-8-30(9-7-29)21-5-10-32-15-21)4-2-16(22)11-19(14-26)28-24(31)23-17-1-3-18(12-17)27-23/h2,4,13,17-19,21,23,27H,1,3,5-12,15H2,(H,28,31)/t17-,18+,19-,21?,23-/m0/s1 HQPKYHAECKWQKT-BRJVMOAUSA-N 150657 US10238633, Example 331::US8987249, 331::US9713606, 331 Dipeptidyl peptidase 1 9.3 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150657 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150657&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430646 252824908 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290086 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)C1=CCN(CC1)C1CCOC1 InChI=1S/C25H31FN4O2/c26-23-13-17(16-5-8-30(9-6-16)22-7-10-32-15-22)1-2-18(23)11-21(14-27)29-25(31)24-19-3-4-20(12-19)28-24/h1-2,5,13,19-22,24,28H,3-4,6-12,15H2,(H,29,31)/t19-,20+,21-,22?,24-/m0/s1 HPIWKFZLWFOWST-NMZQLUBISA-N 150658 US10238633, Example 332::US8987249, 332::US9713606, 332 Dipeptidyl peptidase 1 12.9 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150658 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150658&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430834 252824909 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290087 CN1C2CCC1CN(C2)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H30FN5O/c1-28-19-6-7-20(28)13-29(12-19)18-5-3-14(21(24)10-18)8-17(11-25)27-23(30)22-15-2-4-16(9-15)26-22/h3,5,10,15-17,19-20,22,26H,2,4,6-9,12-13H2,1H3,(H,27,30)/t15-,16+,17-,19?,20?,22-/m0/s1 AFPYZOMVCKOSFX-DVFPXELVSA-N 150659 US10238633, Example 333::US8987249, 333::US9713606, 333 Dipeptidyl peptidase 1 15.3 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150659 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150659&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430881 252824910 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290088 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2N(C3CCNCC3)C(=O)Cc2c1 InChI=1S/C29H32FN5O2/c30-25-14-18(17-4-6-26-21(11-17)15-27(36)35(26)24-7-9-32-10-8-24)1-2-19(25)12-23(16-31)34-29(37)28-20-3-5-22(13-20)33-28/h1-2,4,6,11,14,20,22-24,28,32-33H,3,5,7-10,12-13,15H2,(H,34,37)/t20-,22+,23-,28-/m0/s1 DXRXGECGVNYTMC-HQGMYGGFSA-N 150660 US10238633, Example 334::US8987249, 334::US9713606, 334 Dipeptidyl peptidase 1 22 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150660 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150660&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430819 252824911 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290089 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCNCC1 InChI=1S/C20H26FN5O/c21-18-11-17(26-7-5-23-6-8-26)4-2-13(18)9-16(12-22)25-20(27)19-14-1-3-15(10-14)24-19/h2,4,11,14-16,19,23-24H,1,3,5-10H2,(H,25,27)/t14-,15+,16-,19-/m0/s1 IMHSIFFWUGPDKM-RCJHGTSTSA-N 150530 BDBM150661::US10238633, Example 335::US8987249, 204::US9713606, 335 Dipeptidyl peptidase 1 24.5 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150530&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430619 252824781 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290090 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCN(CC1)C1CCOCC1 InChI=1S/C25H34FN5O2/c26-23-15-22(31-9-7-30(8-10-31)21-5-11-33-12-6-21)4-2-17(23)13-20(16-27)29-25(32)24-18-1-3-19(14-18)28-24/h2,4,15,18-21,24,28H,1,3,5-14H2,(H,29,32)/t18-,19+,20-,24-/m0/s1 PVGDBPFKTDEZEI-VKDGWMQASA-N 150662 US10238633, Example 336::US8987249, 336::US9713606, 336 Dipeptidyl peptidase 1 24.5 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150662 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150662&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430857 252824913 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290091 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)C1CCN(CC1)C1CCOC1 InChI=1S/C25H33FN4O2/c26-23-13-17(16-5-8-30(9-6-16)22-7-10-32-15-22)1-2-18(23)11-21(14-27)29-25(31)24-19-3-4-20(12-19)28-24/h1-2,13,16,19-22,24,28H,3-12,15H2,(H,29,31)/t19-,20+,21-,22?,24-/m0/s1 WHIXYJGAWIPTFA-NMZQLUBISA-N 150663 US10238633, Example 337::US8987249, 337::US9713606, 337 Dipeptidyl peptidase 1 28.2 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150663 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150663&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430651 252824914 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290092 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)C1CCCN(C1)C1CCOC1 InChI=1S/C25H33FN4O2/c26-23-12-16(19-2-1-8-30(14-19)22-7-9-32-15-22)3-4-17(23)10-21(13-27)29-25(31)24-18-5-6-20(11-18)28-24/h3-4,12,18-22,24,28H,1-2,5-11,14-15H2,(H,29,31)/t18-,19?,20+,21-,22?,24-/m0/s1 PLDLYKGVWLEKJA-DQRHXDIBSA-N 150664 US10238633, Example 338::US8987249, 338::US9713606, 338 Dipeptidyl peptidase 1 44.3 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150664 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150664&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430828 252824915 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290093 CN1CCN(CC1)S(=O)(=O)c1cc(ccc1F)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C27H31F2N5O3S/c1-33-8-10-34(11-9-33)38(36,37)25-15-18(5-7-23(25)28)17-2-3-19(24(29)14-17)12-22(16-30)32-27(35)26-20-4-6-21(13-20)31-26/h2-3,5,7,14-15,20-22,26,31H,4,6,8-13H2,1H3,(H,32,35)/t20-,21+,22-,26-/m0/s1 TYOXDYZNTFEUBD-MSZDEVHKSA-N 150665 US10238633, Example 339::US8987249, 339::US9713606, 339 Dipeptidyl peptidase 1 1.3 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150665&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430640 252824916 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290094 CN1CCCN(CC1)S(=O)(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C28H34FN5O3S/c1-33-11-2-12-34(14-13-33)38(36,37)25-9-6-19(7-10-25)20-3-4-21(26(29)17-20)15-24(18-30)32-28(35)27-22-5-8-23(16-22)31-27/h3-4,6-7,9-10,17,22-24,27,31H,2,5,8,11-16H2,1H3,(H,32,35)/t22-,23+,24-,27-/m0/s1 LFMQCYRRSBXTCL-LAOBSVPGSA-N 150666 US10238633, Example 340::US8987249, 340 Dipeptidyl peptidase 1 1.8 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150666 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150666&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430700 252824917 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290095 O=C(NC(Cc1ccc2c3cccc(C(=O)NC4CC4)c3[nH]c(=O)c2c1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 150667 US10238633, Example 341::US8987249, 341::US9713606, 341 Dipeptidyl peptidase 1 7.6 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150667 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150667&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937227 252824918 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290096 CN(C)CCn1cc(ccc1=O)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C25H30FN5O2/c1-30(2)9-10-31-15-19(6-8-23(31)32)16-3-4-17(22(26)13-16)11-21(14-27)29-25(33)24-18-5-7-20(12-18)28-24/h3-4,6,8,13,15,18,20-21,24,28H,5,7,9-12H2,1-2H3,(H,29,33)/t18-,20+,21-,24-/m0/s1 JCPYMYYDSFBUAQ-UQWVPHONSA-N 150668 US10238633, Example 342::US8987249, 342::US9713606, 342 Dipeptidyl peptidase 1 1.3 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150668 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150668&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430321 252824919 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290097 FC(F)Cn1cc(ccc1=O)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H23F3N4O2/c24-19-9-13(16-4-6-21(31)30(11-16)12-20(25)26)1-2-14(19)7-18(10-27)29-23(32)22-15-3-5-17(8-15)28-22/h1-2,4,6,9,11,15,17-18,20,22,28H,3,5,7-8,12H2,(H,29,32)/t15-,17+,18-,22-/m0/s1 XLDYHFLLFRGMMH-PBWVOLNLSA-N 150669 US10238633, Example 343::US8987249, 343::US9713606, 343 Dipeptidyl peptidase 1 4.5 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150669 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150669&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430361 252824920 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290098 CN(C)C1CCCN(C1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H32FN5O/c1-28(2)20-4-3-9-29(14-20)19-8-6-15(21(24)12-19)10-18(13-25)27-23(30)22-16-5-7-17(11-16)26-22/h6,8,12,16-18,20,22,26H,3-5,7,9-11,14H2,1-2H3,(H,27,30)/t16-,17+,18-,20?,22-/m0/s1 GDNGGGSHVJGZPQ-AEJWZEPGSA-N 150670 US10238633, Example 344::US8987249, 344::US9713606, 344 Dipeptidyl peptidase 1 10 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150670 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150670&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90413980 252824921 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290099 CN(C)CC1CCCN(C1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H34FN5O/c1-29(2)14-16-4-3-9-30(15-16)21-8-6-17(22(25)12-21)10-20(13-26)28-24(31)23-18-5-7-19(11-18)27-23/h6,8,12,16,18-20,23,27H,3-5,7,9-11,14-15H2,1-2H3,(H,28,31)/t16?,18-,19+,20-,23-/m0/s1 HSYBJTSDYKJCLC-XPNKYNLISA-N 150671 US10238633, Example 345::US8987249, 345::US9713606, 345 Dipeptidyl peptidase 1 18.4 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150671&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430377 252824922 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290100 CN1CCC(CC1)N1C(=O)Cc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C30H34FN5O2/c1-35-10-8-25(9-11-35)36-27-15-19(3-5-21(27)16-28(36)37)18-2-4-20(26(31)14-18)12-24(17-32)34-30(38)29-22-6-7-23(13-22)33-29/h2-5,14-15,22-25,29,33H,6-13,16H2,1H3,(H,34,38)/t22-,23+,24-,29-/m0/s1 NQWFIIUUUKGYJY-MVPDCNEZSA-N 150672 US10238633, Example 346::US8987249, 346::US9713606, 346 Dipeptidyl peptidase 1 1 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150672&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430825 252824923 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290101 CNc1nc2cc(ccc2[nH]1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 150673 US10238633, Example 347::US8987249, 347::US9713606, 347 Dipeptidyl peptidase 1 8.5 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150673&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430669 252824924 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290102 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CC2CCN(C3CCOC3)C2C1 InChI=1S/C26H34FN5O2/c27-23-11-21(31-13-18-5-7-32(24(18)14-31)22-6-8-34-15-22)4-2-16(23)9-20(12-28)30-26(33)25-17-1-3-19(10-17)29-25/h2,4,11,17-20,22,24-25,29H,1,3,5-10,13-15H2,(H,30,33)/t17-,18?,19+,20-,22?,24?,25-/m0/s1 HNERTVWQTUOXEG-QOCJVYAVSA-N 150674 US10238633, Example 348::US8987249, 348::US9713606, 348 Dipeptidyl peptidase 1 17.6 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150674 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150674&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430684 252824925 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290103 CN1CCC2CN(CC12)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H30FN5O/c1-28-7-6-16-12-29(13-21(16)28)19-5-3-14(20(24)10-19)8-18(11-25)27-23(30)22-15-2-4-17(9-15)26-22/h3,5,10,15-18,21-22,26H,2,4,6-9,12-13H2,1H3,(H,27,30)/t15-,16?,17+,18-,21?,22-/m0/s1 IJCSTYFRTDTKAN-CHXWQNPLSA-N 150675 US10238633, Example 349::US8987249, 349::US9713606, 349 Dipeptidyl peptidase 1 20.6 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150675&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430670 252824926 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290104 COCCN1CCC(C1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H31FN4O2/c1-30-9-8-28-7-6-18(14-28)15-2-3-16(21(24)12-15)10-20(13-25)27-23(29)22-17-4-5-19(11-17)26-22/h2-3,12,17-20,22,26H,4-11,14H2,1H3,(H,27,29)/t17-,18?,19+,20-,22-/m0/s1 IQICHZGNSROSIQ-FPTDZDEXSA-N 150676 US10238633, Example 350::US8987249, 350::US9713606, 350 Dipeptidyl peptidase 1 38.6 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150676&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430831 252824927 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290105 Fc1c(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)ccc2CC(CCc12)N1CCOCC1 InChI=1S/C24H31FN4O2/c25-22-16(11-19(14-26)28-24(30)23-17-3-4-18(12-17)27-23)2-1-15-13-20(5-6-21(15)22)29-7-9-31-10-8-29/h1-2,17-20,23,27H,3-13H2,(H,28,30)/t17-,18+,19-,20?,23-/m0/s1 AOFGEIPQRRXJES-AJOPTGRPSA-N 150677 US10238633, Example 351::US8987249, 351::US9713606, 351 Dipeptidyl peptidase 1 82.8 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150677&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430878 252824928 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290106 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCC2COCC2C1 InChI=1S/C23H29FN4O2/c24-21-9-20(28-6-5-16-12-30-13-17(16)11-28)4-2-14(21)7-19(10-25)27-23(29)22-15-1-3-18(8-15)26-22/h2,4,9,15-19,22,26H,1,3,5-8,11-13H2,(H,27,29)/t15-,16?,17?,18+,19-,22-/m0/s1 FJQGLLQSIMRVNW-MBJMIVNXSA-N 150678 US10238633, Example 352::US8987249, 352::US9713606, 352 Dipeptidyl peptidase 1 17.3 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150678&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430832 252824929 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290107 CN1CC2CCN(C2C1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H30FN5O/c1-28-12-16-6-7-29(21(16)13-28)19-5-3-14(20(24)10-19)8-18(11-25)27-23(30)22-15-2-4-17(9-15)26-22/h3,5,10,15-18,21-22,26H,2,4,6-9,12-13H2,1H3,(H,27,30)/t15-,16?,17+,18-,21?,22-/m0/s1 HEZSCOPWBZQUPX-CHXWQNPLSA-N 150679 US10238633, Example 353::US8987249, 353::US9713606, 353 Dipeptidyl peptidase 1 6.5 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150679&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430880 252824930 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290108 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCC2CN(CC12)C1CCOC1 InChI=1S/C26H34FN5O2/c27-23-11-21(32-7-5-18-13-31(14-24(18)32)22-6-8-34-15-22)4-2-16(23)9-20(12-28)30-26(33)25-17-1-3-19(10-17)29-25/h2,4,11,17-20,22,24-25,29H,1,3,5-10,13-15H2,(H,30,33)/t17-,18?,19+,20-,22?,24?,25-/m0/s1 FUQCVQPIQCQUJA-QOCJVYAVSA-N 150680 US10238633, Example 354::US8987249, 354::US9713606, 354 Dipeptidyl peptidase 1 6.8 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150680&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430818 252824931 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290109 CN1CCO[C@@H]2CN(C[C@H]12)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H30FN5O2/c1-28-6-7-31-21-13-29(12-20(21)28)18-5-3-14(19(24)10-18)8-17(11-25)27-23(30)22-15-2-4-16(9-15)26-22/h3,5,10,15-17,20-22,26H,2,4,6-9,12-13H2,1H3,(H,27,30)/t15-,16+,17-,20-,21+,22-/m0/s1 CQSOXMZXLHYZJS-MNJVBOLNSA-N 150681 US10238633, Example 355::US8987249, 355::US9713606, 355 Dipeptidyl peptidase 1 22.4 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150681&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430475 252824932 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290110 CN1CCO[C@@H]2CCN(C[C@H]12)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H32FN5O2/c1-29-8-9-32-22-6-7-30(14-21(22)29)19-5-3-15(20(25)12-19)10-18(13-26)28-24(31)23-16-2-4-17(11-16)27-23/h3,5,12,16-18,21-23,27H,2,4,6-11,14H2,1H3,(H,28,31)/t16-,17+,18-,21-,22+,23-/m0/s1 KTZQFVFLNYISOX-YNGMKWAISA-N 150682 US10238633, Example 356::US8987249, 356::US9713606, 356 Dipeptidyl peptidase 1 20 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150682&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430477 252824933 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290111 CN1CCO[C@H]2CN(CC[C@H]12)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H32FN5O2/c1-29-8-9-32-22-14-30(7-6-21(22)29)19-5-3-15(20(25)12-19)10-18(13-26)28-24(31)23-16-2-4-17(11-16)27-23/h3,5,12,16-18,21-23,27H,2,4,6-11,14H2,1H3,(H,28,31)/t16-,17+,18-,21-,22-,23-/m0/s1 LULCUNUDANTJSG-FVOHPSJWSA-N 150683 US10238633, Example 357::US8987249, 357::US9713606, 357 Dipeptidyl peptidase 1 33.8 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150683&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430480 252824934 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290112 CN1CCC2(CC(C2)c2ccc(C[C@H](NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)c(F)c2)CC1 InChI=1S/C25H33FN4O/c1-30-8-6-25(7-9-30)13-19(14-25)16-2-3-17(22(26)12-16)10-21(15-27)29-24(31)23-18-4-5-20(11-18)28-23/h2-3,12,18-21,23,28H,4-11,13-14H2,1H3,(H,29,31)/t18-,20+,21-,23-/m0/s1 VYUWIIULBHZCOM-SQMWVJLWSA-N 150684 US10238633, Example 358::US8987249, 358::US9713606, 358 Dipeptidyl peptidase 1 22 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150684 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150684&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430208 252824935 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 290113 CN1CCC2(CC(=C2)c2ccc(C[C@H](NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)c(F)c2)CC1 InChI=1S/C25H31FN4O/c1-30-8-6-25(7-9-30)13-19(14-25)16-2-3-17(22(26)12-16)10-21(15-27)29-24(31)23-18-4-5-20(11-18)28-23/h2-3,12-13,18,20-21,23,28H,4-11,14H2,1H3,(H,29,31)/t18-,20+,21-,23-/m0/s1 CVDOMISMJVCMHM-SQMWVJLWSA-N 150685 US10238633, Example 359::US8987249, 359::US9713606, 359 Dipeptidyl peptidase 1 8.8 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150685 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150685&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430211 252824936 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289756 CN1Cc2ccc(cc2C1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C25H27FN4O/c1-30-13-19-5-3-15(8-20(19)14-30)16-2-4-17(23(26)11-16)9-22(12-27)29-25(31)24-18-6-7-21(10-18)28-24/h2-5,8,11,18,21-22,24,28H,6-7,9-10,13-14H2,1H3,(H,29,31)/t18-,21+,22-,24-/m0/s1 GQBRPHSHOCUJAG-ASLXYRGWSA-N 150327 US10238633, Example 1::US8987249, 1::US9713606, 1 Dipeptidyl peptidase 1 8.6 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150327 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150327&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90414082 252824578 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289757 CN1C(=O)Cc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C25H25FN4O2/c1-30-22-11-15(3-5-17(22)12-23(30)31)14-2-4-16(21(26)10-14)8-20(13-27)29-25(32)24-18-6-7-19(9-18)28-24/h2-5,10-11,18-20,24,28H,6-9,12H2,1H3,(H,29,32)/t18-,19+,20-,24-/m0/s1 MNEOBAAFLAQMKF-VKDGWMQASA-N 150328 US10238633, Example 2::US8987249, 2::US9713606, 2 Dipeptidyl peptidase 1 2 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150328 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150328&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90414333 252824579 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289758 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2C(=O)OCc2c1 InChI=1S/C24H22FN3O3/c25-21-10-14(13-4-6-20-17(7-13)12-31-24(20)30)1-2-15(21)8-19(11-26)28-23(29)22-16-3-5-18(9-16)27-22/h1-2,4,6-7,10,16,18-19,22,27H,3,5,8-9,12H2,(H,28,29)/t16-,18+,19-,22-/m0/s1 WTHQKFUPVXDWIU-ZBPHCFQXSA-N 150329 US10238633, Example 3::US8987249, 3::US9713606, 3 Dipeptidyl peptidase 1 0.7 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150329 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150329&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90413943 252824580 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289759 CS(=O)(=O)c1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H24FN3O3S/c1-31(29,30)20-4-2-3-14(11-20)15-5-6-16(21(24)12-15)9-19(13-25)27-23(28)22-17-7-8-18(10-17)26-22/h2-6,11-12,17-19,22,26H,7-10H2,1H3,(H,27,28)/t17-,18+,19-,22-/m0/s1 SLANNUBDKTXJNP-WEMPKCCASA-N 150330 US10238633, Example 4::US8987249, 4::US9713606, 4 Dipeptidyl peptidase 1 1.4 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150330 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150330&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90415865 252824581 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289760 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1C[C@@H]2CC[C@H]1C2)C#N)-n1cc(nn1)-c1ccc2[nH]ccc2c1 150331 US8987249, 5 Dipeptidyl peptidase 1 4 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150331 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150331&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90440135 252824582 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289761 CN1CCN(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H28FN5O/c1-26-6-8-27(9-7-26)18-5-3-14(19(22)12-18)10-17(13-23)25-21(28)20-15-2-4-16(11-15)24-20/h3,5,12,15-17,20,24H,2,4,6-11H2,1H3,(H,25,28)/t15-,16+,17-,20-/m0/s1 ZECDJSBLEVMTSQ-CLWJZODNSA-N 150332 US10238633, Example 6::US8987249, 6::US9713606, 6 Dipeptidyl peptidase 1 10.7 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150332 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150332&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90413749 252824583 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289762 CC(=O)n1nc(cc1C)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H24FN5O2/c1-12-7-20(27-28(12)13(2)29)15-4-3-14(19(23)10-15)8-18(11-24)26-22(30)21-16-5-6-17(9-16)25-21/h3-4,7,10,16-18,21,25H,5-6,8-9H2,1-2H3,(H,26,30)/t16-,17+,18?,21-/m0/s1 LZLTXNWOZBVHCY-APZTZJSISA-N 150333 US10238633, Example 7::US8987249, 7::US9713606, 7 Dipeptidyl peptidase 1 1.9 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150333 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150333&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90413606 252824584 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289763 O=C(NC(Cc1ccc2[nH]ncc2c1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 150334 US10238633, Example 8::US8987249, 8::US9713606, 8 Dipeptidyl peptidase 1 679.4 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150334&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90415654 252824585 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289764 O=C(NC(Cc1ccc2c3ccccc3[nH]c(=O)c2c1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 150335 US10238633, Example 9::US8987249, 9::US9713606, 9 Dipeptidyl peptidase 1 9.6 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150335 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150335&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937188 252824586 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289765 CN1C(=O)C(=O)c2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C25H23FN4O3/c1-30-21-11-14(5-7-19(21)23(31)25(30)33)13-2-3-15(20(26)10-13)8-18(12-27)29-24(32)22-16-4-6-17(9-16)28-22/h2-3,5,7,10-11,16-18,22,28H,4,6,8-9H2,1H3,(H,29,32)/t16-,17+,18-,22-/m0/s1 MQKJSVBPRAMRJU-SUWCGCSTSA-N 150336 US10238633, Example 10::US8987249, 10::US9713606, 10 Dipeptidyl peptidase 1 1.5 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150336&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443233 252824587 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289766 Fc1cc(ccc1CC(NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2C(=O)OCc2c1 InChI=1S/C24H22FN3O3/c25-21-10-14(13-4-6-20-17(7-13)12-31-24(20)30)1-2-15(21)8-19(11-26)28-23(29)22-16-3-5-18(9-16)27-22/h1-2,4,6-7,10,16,18-19,22,27H,3,5,8-9,12H2,(H,28,29)/t16-,18+,19?,22-/m0/s1 WTHQKFUPVXDWIU-AAEOLZRXSA-N 150337 US10238633, Example 11::US8987249, 11::US9713606, 11 Dipeptidyl peptidase 1 1.7 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150337 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150337&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430788 252824588 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289767 CS(=O)(=O)c1ccc(cc1F)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H23F2N3O3S/c1-32(30,31)21-7-5-14(11-20(21)25)13-2-3-15(19(24)10-13)8-18(12-26)28-23(29)22-16-4-6-17(9-16)27-22/h2-3,5,7,10-11,16-18,22,27H,4,6,8-9H2,1H3,(H,28,29)/t16-,17+,18-,22-/m0/s1 ZGJRMKDBJBZGHJ-SUWCGCSTSA-N 150338 US10238633, Example 12::US8987249, 12::US9713606, 12 Dipeptidyl peptidase 1 1.9 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150338 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150338&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430789 252824589 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289768 COC(=O)Cn1cc(cn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H24FN5O3/c1-31-20(29)12-28-11-16(10-25-28)13-2-3-14(19(23)8-13)6-18(9-24)27-22(30)21-15-4-5-17(7-15)26-21/h2-3,8,10-11,15,17-18,21,26H,4-7,12H2,1H3,(H,27,30)/t15-,17+,18-,21-/m0/s1 NHUZJCGXGLXXCK-DKXUYOFUSA-N 150339 US10238633, Example 13::US8987249, 13::US9713606, 13 Dipeptidyl peptidase 1 1.9 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150339 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150339&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430783 252824590 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289769 CS(=O)(=O)c1cc(ccc1C#N)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H23FN4O3S/c1-33(31,32)22-11-15(3-5-18(22)12-26)14-2-4-16(21(25)10-14)8-20(13-27)29-24(30)23-17-6-7-19(9-17)28-23/h2-5,10-11,17,19-20,23,28H,6-9H2,1H3,(H,29,30)/t17-,19+,20-,23-/m0/s1 AUHJWFLPELHPMB-USKVXJDGSA-N 150340 US10238633, Example 14::US8987249, 14::US9713606, 14 Dipeptidyl peptidase 1 2 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150340&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443035 252824591 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289770 CN1C(=O)Cc2ccc(cc12)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C25H25FN4O2/c1-30-22-11-15(3-5-17(22)12-23(30)31)14-2-4-16(21(26)10-14)8-20(13-27)29-25(32)24-18-6-7-19(9-18)28-24/h2-5,10-11,18-20,24,28H,6-9,12H2,1H3,(H,29,32)/t18-,19+,20?,24-/m0/s1 MNEOBAAFLAQMKF-BQTZMPSMSA-N 150341 US10238633, Example 15::US8987249, 15::US9713606, 15 Dipeptidyl peptidase 1 2 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150341 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150341&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430760 252824592 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289771 CS(=O)(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H24FN3O3S/c1-31(29,30)20-8-5-14(6-9-20)15-2-3-16(21(24)12-15)10-19(13-25)27-23(28)22-17-4-7-18(11-17)26-22/h2-3,5-6,8-9,12,17-19,22,26H,4,7,10-11H2,1H3,(H,27,28)/t17-,18+,19-,22-/m0/s1 KKCIOVAGWAIFAX-WEMPKCCASA-N 150342 US10238633, Example 16::US8987249, 16::US9713606, 16 Dipeptidyl peptidase 1 2.6 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150342 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150342&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430804 252824593 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289772 COC(=O)c1cc(cs1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H22FN3O3S/c1-29-22(28)19-9-15(11-30-19)12-2-3-13(18(23)8-12)6-17(10-24)26-21(27)20-14-4-5-16(7-14)25-20/h2-3,8-9,11,14,16-17,20,25H,4-7H2,1H3,(H,26,27)/t14-,16+,17-,20-/m0/s1 QSEMIFYIVMRBGQ-FORWCCJISA-N 150343 US10238633, Example 17::US8987249, 17::US9713606, 17 Dipeptidyl peptidase 1 2.6 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150343 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150343&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430761 252824594 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289773 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccsc1 InChI=1S/C20H20FN3OS/c21-18-9-12(15-5-6-26-11-15)1-2-13(18)7-17(10-22)24-20(25)19-14-3-4-16(8-14)23-19/h1-2,5-6,9,11,14,16-17,19,23H,3-4,7-8H2,(H,24,25)/t14-,16+,17-,19-/m0/s1 CUGBXLAZKQOEHU-RUENVJTFSA-N 150344 US10238633, Example 18::US8987249, 18::US9713606, 18 Dipeptidyl peptidase 1 2.7 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150344 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150344&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430762 252824595 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289774 CS(=O)(=O)c1cc(ccc1C#N)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H23FN4O3S/c1-33(31,32)22-11-15(3-5-18(22)12-26)14-2-4-16(21(25)10-14)8-20(13-27)29-24(30)23-17-6-7-19(9-17)28-23/h2-5,10-11,17,19-20,23,28H,6-9H2,1H3,(H,29,30)/t17-,19+,20?,23-/m0/s1 AUHJWFLPELHPMB-GKUGZCSRSA-N 150345 US10238633, Example 19::US8987249, 19::US9713606, 19 Dipeptidyl peptidase 1 2.8 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150345&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443252 252824596 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289775 CC(=O)n1cc(cn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H22FN5O2/c1-12(28)27-11-16(10-24-27)13-2-3-14(19(22)8-13)6-18(9-23)26-21(29)20-15-4-5-17(7-15)25-20/h2-3,8,10-11,15,17-18,20,25H,4-7H2,1H3,(H,26,29)/t15-,17+,18-,20-/m0/s1 YGHKDCMFTPEJME-NFBUACBFSA-N 150346 US10238633, Example 20::US8987249, 20::US9713606, 20 Dipeptidyl peptidase 1 3.1 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150346 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150346&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443158 252824597 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289776 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnn(CC2CCOC2)c1 InChI=1S/C24H28FN5O2/c25-22-9-16(19-11-27-30(13-19)12-15-5-6-32-14-15)1-2-17(22)7-21(10-26)29-24(31)23-18-3-4-20(8-18)28-23/h1-2,9,11,13,15,18,20-21,23,28H,3-8,12,14H2,(H,29,31)/t15?,18-,20+,21-,23-/m0/s1 CWXBPKJABGXNSH-ZDOHZWEYSA-N 150347 US10238633, Example 21::US8987249, 21::US9713606, 21 Dipeptidyl peptidase 1 3.1 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150347 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150347&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430561 252824598 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289777 Fc1cc(ccc1CC(NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2CC(=O)Nc2c1 InChI=1S/C24H23FN4O2/c25-20-9-13(14-2-4-16-11-22(30)29-21(16)10-14)1-3-15(20)7-19(12-26)28-24(31)23-17-5-6-18(8-17)27-23/h1-4,9-10,17-19,23,27H,5-8,11H2,(H,28,31)(H,29,30)/t17-,18+,19?,23-/m0/s1 GRTBTBDXCOSHDK-UNEJAWRNSA-N 150348 US10238633, Example 22::US8987249, 22::US9713606, 22 Dipeptidyl peptidase 1 3.3 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150348 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150348&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430555 252824599 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289778 CC(C)(C)n1cc(cn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H28FN5O/c1-23(2,3)29-13-17(12-26-29)14-4-5-15(20(24)10-14)8-19(11-25)28-22(30)21-16-6-7-18(9-16)27-21/h4-5,10,12-13,16,18-19,21,27H,6-9H2,1-3H3,(H,28,30)/t16-,18+,19-,21-/m0/s1 HVHUNYHQWGGPMT-KRQVXIAISA-N 150349 US10238633, Example 23::US8987249, 23::US9713606, 23 Dipeptidyl peptidase 1 3.7 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150349 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150349&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430551 252824600 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289779 CN1C(=O)Cc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1F InChI=1S/C25H24F2N4O2/c1-31-20-10-13(2-3-14(20)11-21(31)32)19-7-5-15(22(26)23(19)27)8-18(12-28)30-25(33)24-16-4-6-17(9-16)29-24/h2-3,5,7,10,16-18,24,29H,4,6,8-9,11H2,1H3,(H,30,33)/t16-,17+,18-,24-/m0/s1 LJUVJDUKKVZRFZ-AIDSWVIKSA-N 150350 US10238633, Example 24::US8987249, 24::US9713606, 24 Dipeptidyl peptidase 1 3.7 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150350 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150350&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430553 252824601 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289780 Cc1ncc(s1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C20H21FN4OS/c1-11-23-10-18(27-11)13-3-2-12(17(21)8-13)6-16(9-22)25-20(26)19-14-4-5-15(7-14)24-19/h2-3,8,10,14-16,19,24H,4-7H2,1H3,(H,25,26)/t14-,15+,16-,19-/m0/s1 SKTGXDCDCGNQOW-RCJHGTSTSA-N 150351 US10238633, Example 25::US8987249, 25::US9713606, 25 Dipeptidyl peptidase 1 3.9 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150351&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430587 252824602 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289781 CCn1cc(cn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H24FN5O/c1-2-27-12-16(11-24-27)13-3-4-14(19(22)9-13)7-18(10-23)26-21(28)20-15-5-6-17(8-15)25-20/h3-4,9,11-12,15,17-18,20,25H,2,5-8H2,1H3,(H,26,28)/t15-,17+,18-,20-/m0/s1 BOEDWXHZEWDSOJ-NFBUACBFSA-N 150352 US10238633, Example 26::US8987249, 26::US9713606, 26 Dipeptidyl peptidase 1 4 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150352 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150352&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430578 252824603 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289782 Cc1ccc(o1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H22FN3O2/c1-12-2-7-19(27-12)14-4-3-13(18(22)10-14)8-17(11-23)25-21(26)20-15-5-6-16(9-15)24-20/h2-4,7,10,15-17,20,24H,5-6,8-9H2,1H3,(H,25,26)/t15-,16+,17-,20-/m0/s1 WPUSIXGXCBPYHG-CLWJZODNSA-N 150353 US10238633, Example 27::US8987249, 27::US9713606, 27 Dipeptidyl peptidase 1 4 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150353 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150353&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430579 252824604 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289783 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnn(CC2CCCCO2)c1 InChI=1S/C25H30FN5O2/c26-23-11-16(19-13-28-31(14-19)15-22-3-1-2-8-33-22)4-5-17(23)9-21(12-27)30-25(32)24-18-6-7-20(10-18)29-24/h4-5,11,13-14,18,20-22,24,29H,1-3,6-10,15H2,(H,30,32)/t18-,20+,21-,22?,24-/m0/s1 SLLIUCDDDQLBAQ-MVUGTHIMSA-N 150354 US10238633, Example 28::US8987249, 28::US9713606, 28 Dipeptidyl peptidase 1 4.1 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150354 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150354&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430571 252824605 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289784 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2CC(=O)Nc2c1 InChI=1S/C24H23FN4O2/c25-20-9-13(14-2-4-16-11-22(30)29-21(16)10-14)1-3-15(20)7-19(12-26)28-24(31)23-17-5-6-18(8-17)27-23/h1-4,9-10,17-19,23,27H,5-8,11H2,(H,28,31)(H,29,30)/t17-,18+,19-,23-/m0/s1 GRTBTBDXCOSHDK-YWNPBTLJSA-N 150355 US10238633, Example 29::US8987249, 29::US9713606, 29 Dipeptidyl peptidase 1 4.2 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150355&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430677 252824606 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289785 CCCn1cc(cn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H26FN5O/c1-2-7-28-13-17(12-25-28)14-3-4-15(20(23)10-14)8-19(11-24)27-22(29)21-16-5-6-18(9-16)26-21/h3-4,10,12-13,16,18-19,21,26H,2,5-9H2,1H3,(H,27,29)/t16-,18+,19-,21-/m0/s1 LCAYDHNDEUNJEG-KRQVXIAISA-N 150356 US10238633, Example 30::US8987249, 30::US9713606, 30 Dipeptidyl peptidase 1 4.2 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150356 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150356&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430567 252824607 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289786 CN1C(=O)Cc2ccc(cc12)-c1cc(F)c(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1F InChI=1S/C25H24F2N4O2/c1-31-22-9-13(2-3-14(22)10-23(31)32)19-11-20(26)16(8-21(19)27)7-18(12-28)30-25(33)24-15-4-5-17(6-15)29-24/h2-3,8-9,11,15,17-18,24,29H,4-7,10H2,1H3,(H,30,33)/t15-,17+,18?,24-/m0/s1 JXOWBXXJEMLQAI-GUZYLCRVSA-N 150357 US10238633, Example 31::US8987249, 31 Dipeptidyl peptidase 1 4.3 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150357 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150357&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430305 252824608 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289787 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCN(CC1)c1ccccc1 InChI=1S/C26H30FN5O/c27-24-16-23(32-12-10-31(11-13-32)22-4-2-1-3-5-22)9-7-18(24)14-21(17-28)30-26(33)25-19-6-8-20(15-19)29-25/h1-5,7,9,16,19-21,25,29H,6,8,10-15H2,(H,30,33)/t19-,20+,21-,25-/m0/s1 FPIYYDMSEAXZFH-PDFGSZSQSA-N 150358 US10238633, Example 32::US8987249, 32::US9713606, 32 Dipeptidyl peptidase 1 4.5 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150358&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90415523 252824609 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289788 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc(s1)C(F)(F)F InChI=1S/C21H19F4N3OS/c22-16-9-12(17-5-6-18(30-17)21(23,24)25)2-1-11(16)7-15(10-26)28-20(29)19-13-3-4-14(8-13)27-19/h1-2,5-6,9,13-15,19,27H,3-4,7-8H2,(H,28,29)/t13-,14+,15-,19-/m0/s1 HRFVYBFWQMQWTD-YGTYGHESSA-N 150359 US10238633, Example 33::US8987249, 33::US9713606, 33 Dipeptidyl peptidase 1 4.5 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150359 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150359&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430300 252824610 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289789 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2COC(=O)c2c1 InChI=1S/C24H22FN3O3/c25-21-10-14(13-2-4-17-12-31-24(30)20(17)9-13)1-3-15(21)7-19(11-26)28-23(29)22-16-5-6-18(8-16)27-22/h1-4,9-10,16,18-19,22,27H,5-8,12H2,(H,28,29)/t16-,18+,19-,22-/m0/s1 IHMLKNVVWQAOBN-ZBPHCFQXSA-N 150360 US10238633, Example 34::US8987249, 34::US9713606, 34 Dipeptidyl peptidase 1 4.6 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150360 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150360&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430302 252824611 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289790 Fc1cc(ccc1CC(NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc(C#N)c(F)c1 InChI=1S/C23H20F2N4O/c24-20-9-13(14-2-4-17(11-26)21(25)10-14)1-3-15(20)7-19(12-27)29-23(30)22-16-5-6-18(8-16)28-22/h1-4,9-10,16,18-19,22,28H,5-8H2,(H,29,30)/t16-,18+,19?,22-/m0/s1 ZACSQEJERMQYBO-AAEOLZRXSA-N 150361 US10238633, Example 35::US8987249, 35::US9713606, 35 Dipeptidyl peptidase 1 4.6 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150361 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150361&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430303 252824612 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289791 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cccs1 InChI=1S/C20H20FN3OS/c21-17-10-13(18-2-1-7-26-18)4-3-12(17)8-16(11-22)24-20(25)19-14-5-6-15(9-14)23-19/h1-4,7,10,14-16,19,23H,5-6,8-9H2,(H,24,25)/t14-,15+,16-,19-/m0/s1 XFLYDHSZANAGSB-RCJHGTSTSA-N 150362 US10238633, Example 36::US8987249, 36::US9713606, 36 Dipeptidyl peptidase 1 4.7 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150362&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430301 252824613 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289792 NS(=O)(=O)c1cccc(c1)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H23FN4O3S/c23-20-11-14(13-2-1-3-19(10-13)31(25,29)30)4-5-15(20)8-18(12-24)27-22(28)21-16-6-7-17(9-16)26-21/h1-5,10-11,16-18,21,26H,6-9H2,(H,27,28)(H2,25,29,30)/t16-,17+,18?,21-/m0/s1 YOUYIXZXGRAFJC-APZTZJSISA-N 150363 US10238633, Example 37::US8987249, 37 Dipeptidyl peptidase 1 4.7 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150363 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150363&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430855 252824614 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289793 CC(=O)NCCn1cc(cn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H27FN6O2/c1-14(31)26-6-7-30-13-18(12-27-30)15-2-3-16(21(24)10-15)8-20(11-25)29-23(32)22-17-4-5-19(9-17)28-22/h2-3,10,12-13,17,19-20,22,28H,4-9H2,1H3,(H,26,31)(H,29,32)/t17-,19+,20-,22-/m0/s1 AZUWHWHOUQWSGG-UFGBVDADSA-N 150364 US10238633, Example 38::US8987249, 38::US9713606, 38 Dipeptidyl peptidase 1 4.8 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150364 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150364&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937189 252824615 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289794 Cc1c(cnn1C)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H24FN5O/c1-12-18(11-24-27(12)2)13-3-4-14(19(22)9-13)7-17(10-23)26-21(28)20-15-5-6-16(8-15)25-20/h3-4,9,11,15-17,20,25H,5-8H2,1-2H3,(H,26,28)/t15-,16+,17-,20-/m0/s1 BXMGRZWIJVZYAS-CLWJZODNSA-N 150365 US10238633, Example 39::US8987249, 39::US9713606, 65 Dipeptidyl peptidase 1 5.1 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150365 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150365&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430769 252824616 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289795 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@H]2C[C@@H]1[C@@H]1C[C@H]21)C#N)-c1ccc(s1)C#N InChI=1S/C22H19FN4OS/c23-18-6-12(20-4-3-14(10-25)29-20)2-1-11(18)5-13(9-24)26-22(28)21-17-8-19(27-21)16-7-15(16)17/h1-4,6,13,15-17,19,21,27H,5,7-8H2,(H,26,28)/t13-,15+,16-,17+,19-,21-/m0/s1 LWDWTRJKZPTFHH-ARFSGQLGSA-N 150366 US8987249, 40::US9713606, 40 Dipeptidyl peptidase 1 5.1 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150366 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150366&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430770 252824617 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289796 Fc1cc(ccc1CC(NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2C(=O)NCc2c1 InChI=1S/C24H23FN4O2/c25-21-10-14(13-4-6-20-17(7-13)12-27-23(20)30)1-2-15(21)8-19(11-26)29-24(31)22-16-3-5-18(9-16)28-22/h1-2,4,6-7,10,16,18-19,22,28H,3,5,8-9,12H2,(H,27,30)(H,29,31)/t16-,18+,19?,22-/m0/s1 AUFRBRNWPXRXNC-AAEOLZRXSA-N 150367 US10238633, Example 41::US8987249, 41::US9713606, 41 Dipeptidyl peptidase 1 5.3 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150367 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150367&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430724 252824618 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289797 CN1CCc2cc(ccc2C1=O)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C26H27FN4O2/c1-31-9-8-17-10-15(5-7-22(17)26(31)33)16-2-3-18(23(27)13-16)11-21(14-28)30-25(32)24-19-4-6-20(12-19)29-24/h2-3,5,7,10,13,19-21,24,29H,4,6,8-9,11-12H2,1H3,(H,30,32)/t19-,20+,21-,24-/m0/s1 XZKCAVQABJPIBE-XARGGIHNSA-N 150368 US10238633, Example 42::US8987249, 42::US9713606, 42 Dipeptidyl peptidase 1 5.3 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150368 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150368&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430764 252824619 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289798 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCN2CCOCC2C1 InChI=1S/C23H30FN5O2/c24-21-11-19(29-6-5-28-7-8-31-14-20(28)13-29)4-2-15(21)9-18(12-25)27-23(30)22-16-1-3-17(10-16)26-22/h2,4,11,16-18,20,22,26H,1,3,5-10,13-14H2,(H,27,30)/t16-,17+,18-,20?,22-/m0/s1 SOLOVPGTCODBHF-AEJWZEPGSA-N 150369 US10238633, Example 43::US8987249, 43::US9713606, 43 Dipeptidyl peptidase 1 5.6 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150369 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150369&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430331 252824620 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289799 COCCn1cc(cn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H26FN5O2/c1-30-7-6-28-13-17(12-25-28)14-2-3-15(20(23)10-14)8-19(11-24)27-22(29)21-16-4-5-18(9-16)26-21/h2-3,10,12-13,16,18-19,21,26H,4-9H2,1H3,(H,27,29)/t16-,18+,19-,21-/m0/s1 IQMJMZXJSJWJBP-KRQVXIAISA-N 150370 US10238633, Example 44::US8987249, 44::US9713606, 44 Dipeptidyl peptidase 1 5.9 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150370 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150370&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443235 252824621 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289800 Fc1cc(ccc1C[C@@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2ncsc2c1 InChI=1S/C23H21FN4OS/c24-19-9-13(14-4-6-20-21(10-14)30-12-26-20)1-2-15(19)7-18(11-25)28-23(29)22-16-3-5-17(8-16)27-22/h1-2,4,6,9-10,12,16-18,22,27H,3,5,7-8H2,(H,28,29)/t16-,17+,18+,22-/m0/s1 MAGRORJEPPDWJZ-FBAVSBLXSA-N 150371 US10238633, Example 45::US8987249, 45::US9713606, 45 Dipeptidyl peptidase 1 6.3 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150371 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150371&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430332 252824622 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289801 CCc1ncc(s1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H23FN4OS/c1-2-19-24-11-18(28-19)13-4-3-12(17(22)9-13)7-16(10-23)26-21(27)20-14-5-6-15(8-14)25-20/h3-4,9,11,14-16,20,25H,2,5-8H2,1H3,(H,26,27)/t14-,15+,16-,20-/m0/s1 UQUJAZLXHZCONU-QOIOWGMHSA-N 150372 US10238633, Example 46::US8987249, 46 Dipeptidyl peptidase 1 6.9 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150372 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150372&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430379 252824623 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289802 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-n1cc(COc2ccccc2)nn1 InChI=1S/C25H25FN6O2/c26-23-12-21(32-14-20(30-31-32)15-34-22-4-2-1-3-5-22)9-7-16(23)10-19(13-27)29-25(33)24-17-6-8-18(11-17)28-24/h1-5,7,9,12,14,17-19,24,28H,6,8,10-11,15H2,(H,29,33)/t17-,18+,19-,24-/m0/s1 YQMDZGGJGGSBDR-YDLHNXBPSA-N 150373 US10238633, Example 47::US8987249, 47::US9713606, 47 Dipeptidyl peptidase 1 7.2 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150373 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150373&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90440137 252824624 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289803 CC(C)CC(=O)n1cc(cn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H28FN5O2/c1-14(2)7-22(31)30-13-18(12-27-30)15-3-4-16(21(25)10-15)8-20(11-26)29-24(32)23-17-5-6-19(9-17)28-23/h3-4,10,12-14,17,19-20,23,28H,5-9H2,1-2H3,(H,29,32)/t17-,19+,20-,23-/m0/s1 HRUNAKRSSYTYRA-USKVXJDGSA-N 150374 US10238633, Example 48::US8987249, 48::US9713606, 48 Dipeptidyl peptidase 1 7.2 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150374 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150374&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443268 252824625 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289804 Fc1cc(ccc1CC(NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2C(=O)NCCc2c1 InChI=1S/C25H25FN4O2/c26-22-12-15(14-4-6-21-16(9-14)7-8-28-24(21)31)1-2-17(22)10-20(13-27)30-25(32)23-18-3-5-19(11-18)29-23/h1-2,4,6,9,12,18-20,23,29H,3,5,7-8,10-11H2,(H,28,31)(H,30,32)/t18-,19+,20?,23-/m0/s1 GEDCUYAXKGCEAP-SRDOODBNSA-N 150375 US10238633, Example 49::US8987249, 49::US9713606, 49 Dipeptidyl peptidase 1 7.3 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150375 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150375&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430681 252824626 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289805 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnn(CC2CCCO2)c1 InChI=1S/C24H28FN5O2/c25-22-10-15(18-12-27-30(13-18)14-21-2-1-7-32-21)3-4-16(22)8-20(11-26)29-24(31)23-17-5-6-19(9-17)28-23/h3-4,10,12-13,17,19-21,23,28H,1-2,5-9,14H2,(H,29,31)/t17-,19+,20-,21?,23-/m0/s1 HMZMPMLDAMDPBI-XHISBUKVSA-N 150376 US10238633, Example 50::US8987249, 50::US9713606, 50 Dipeptidyl peptidase 1 7.4 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150376 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150376&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430682 252824627 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289806 CNS(=O)(=O)c1ccc(cc1)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H25FN4O3S/c1-26-32(30,31)20-8-5-14(6-9-20)15-2-3-16(21(24)12-15)10-19(13-25)28-23(29)22-17-4-7-18(11-17)27-22/h2-3,5-6,8-9,12,17-19,22,26-27H,4,7,10-11H2,1H3,(H,28,29)/t17-,18+,19?,22-/m0/s1 YCLHWAIRELKEQO-HJKBJPMPSA-N 150377 US10238633, Example 51::US8987249, 51::US9713606, 51 Dipeptidyl peptidase 1 7.5 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150377 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150377&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430653 252824628 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289807 CS(=O)(=O)c1cc(ccc1C#N)-c1cc(F)c(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H22F2N4O3S/c1-34(32,33)22-9-13(2-3-15(22)11-27)16-7-20(25)19(21(26)8-16)10-18(12-28)30-24(31)23-14-4-5-17(6-14)29-23/h2-3,7-9,14,17-18,23,29H,4-6,10H2,1H3,(H,30,31)/t14-,17+,18?,23-/m0/s1 APWWFYPMQQAZJM-JRRJEJKYSA-N 150378 US10238633, Example 52::US8987249, 52::US9713606, 52 Dipeptidyl peptidase 1 7.6 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150378 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150378&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430599 252824629 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289808 NC(=O)c1cccc(c1)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H23FN4O2/c24-20-11-14(13-2-1-3-17(8-13)22(26)29)4-5-15(20)9-19(12-25)28-23(30)21-16-6-7-18(10-16)27-21/h1-5,8,11,16,18-19,21,27H,6-7,9-10H2,(H2,26,29)(H,28,30)/t16-,18+,19?,21-/m0/s1 URKPBBPYGGQLCL-PLPRGGQXSA-N 150379 US10238633, Example 53::US8987249, 53::US9713606, 53 Dipeptidyl peptidase 1 7.9 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150379 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150379&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430609 252824630 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289809 CS(=O)(=O)c1ccc(cc1)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H24FN3O3S/c1-31(29,30)20-8-5-14(6-9-20)15-2-3-16(21(24)12-15)10-19(13-25)27-23(28)22-17-4-7-18(11-17)26-22/h2-3,5-6,8-9,12,17-19,22,26H,4,7,10-11H2,1H3,(H,27,28)/t17-,18+,19?,22-/m0/s1 KKCIOVAGWAIFAX-HJKBJPMPSA-N 150380 US10238633, Example 54::US8987249, 54::US9713606, 54 Dipeptidyl peptidase 1 8.2 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150380 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150380&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430765 252824631 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289810 CC(=O)N1CCC(Cn2cc(cn2)-c2ccc(C[C@H](NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)c(F)c2)CC1 InChI=1S/C27H33FN6O2/c1-17(35)33-8-6-18(7-9-33)15-34-16-22(14-30-34)19-2-3-20(25(28)12-19)10-24(13-29)32-27(36)26-21-4-5-23(11-21)31-26/h2-3,12,14,16,18,21,23-24,26,31H,4-11,15H2,1H3,(H,32,36)/t21-,23+,24-,26-/m0/s1 BIHZNSYCANDRTI-YUZJIJRXSA-N 150381 US10238633, Example 55::US8987249, 55::US9713606, 55 Dipeptidyl peptidase 1 8.2 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150381 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150381&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430715 252824632 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289811 NS(=O)(=O)c1ccc(cc1)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H23FN4O3S/c23-20-11-14(13-4-7-19(8-5-13)31(25,29)30)1-2-15(20)9-18(12-24)27-22(28)21-16-3-6-17(10-16)26-21/h1-2,4-5,7-8,11,16-18,21,26H,3,6,9-10H2,(H,27,28)(H2,25,29,30)/t16-,17+,18?,21-/m0/s1 JPKDSNDSOPINLH-APZTZJSISA-N 150382 US10238633, Example 56::US8987249, 56::US9713606, 56 Dipeptidyl peptidase 1 8.3 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150382 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150382&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430748 252824633 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289812 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnn(CC2CCOCC2)c1 InChI=1S/C25H30FN5O2/c26-23-11-17(20-13-28-31(15-20)14-16-5-7-33-8-6-16)1-2-18(23)9-22(12-27)30-25(32)24-19-3-4-21(10-19)29-24/h1-2,11,13,15-16,19,21-22,24,29H,3-10,14H2,(H,30,32)/t19-,21+,22-,24-/m0/s1 DONGIUVRNSCBKX-OHCHIEETSA-N 150383 US10238633, Example 57::US8987249, 57::US9713606, 57 Dipeptidyl peptidase 1 8.3 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150383 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150383&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430727 252824634 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289813 Cc1cc(n[nH]1)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 150384 US10238633, Example 58::US8987249, 58::US9713606, 58 Dipeptidyl peptidase 1 8.4 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150384 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150384&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430774 252824635 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289814 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnc(s1)N1CCOCC1 InChI=1S/C23H26FN5O2S/c24-19-11-15(20-13-26-23(32-20)29-5-7-31-8-6-29)2-1-14(19)9-18(12-25)28-22(30)21-16-3-4-17(10-16)27-21/h1-2,11,13,16-18,21,27H,3-10H2,(H,28,30)/t16-,17+,18-,21-/m0/s1 VBXNUQLHVDGVOH-NYUBLWNDSA-N 150385 US10238633, Example 59::US8987249, 59::US9713606, 59 Dipeptidyl peptidase 1 8.5 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150385 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150385&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430869 252824636 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289815 Cn1nc2ccccc2c1-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H24FN5O/c1-30-23(19-4-2-3-5-21(19)29-30)16-7-6-14(20(25)12-16)10-18(13-26)28-24(31)22-15-8-9-17(11-15)27-22/h2-7,12,15,17-18,22,27H,8-11H2,1H3,(H,28,31)/t15-,17+,18-,22-/m0/s1 JXCFAQSIBMJFEG-PBWVOLNLSA-N 150386 US10238633, Example 60::US8987249, 60::US9713606, 60 Dipeptidyl peptidase 1 8.7 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150386 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150386&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430799 252824637 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289816 CN1C(=O)Cc2ccc(cc12)-c1cc(F)c(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C25H24F2N4O2/c1-31-22-9-13(2-3-14(22)10-23(31)32)16-7-20(26)19(21(27)8-16)11-18(12-28)30-25(33)24-15-4-5-17(6-15)29-24/h2-3,7-9,15,17-18,24,29H,4-6,10-11H2,1H3,(H,30,33)/t15-,17+,18?,24-/m0/s1 YIKYGCSOAIKXDX-GUZYLCRVSA-N 150387 US10238633, Example 61::US8987249, 61::US9713606, 61 Dipeptidyl peptidase 1 8.7 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150387 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150387&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430800 252824638 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289817 CS(=O)(=O)Nc1ccc(cc1)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H25FN4O3S/c1-32(30,31)28-18-7-4-14(5-8-18)15-2-3-16(21(24)12-15)10-20(13-25)27-23(29)22-17-6-9-19(11-17)26-22/h2-5,7-8,12,17,19-20,22,26,28H,6,9-11H2,1H3,(H,27,29)/t17-,19+,20?,22-/m0/s1 VTAUSOLFMBFCJS-FGODIZBMSA-N 150388 US10238633, Example 62::US8987249, 62::US9713606, 62 Dipeptidyl peptidase 1 9.1 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150388 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150388&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430768 252824639 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289818 Cc1cc(-c2ccc(C[C@H](NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)c(F)c2)n(C)n1 InChI=1S/C21H24FN5O/c1-12-7-19(27(2)26-12)14-4-3-13(18(22)10-14)8-17(11-23)25-21(28)20-15-5-6-16(9-15)24-20/h3-4,7,10,15-17,20,24H,5-6,8-9H2,1-2H3,(H,25,28)/t15-,16+,17-,20-/m0/s1 HXPAVZPKUOICMH-CLWJZODNSA-N 150389 US10238633, Example 63::US8987249, 63 Dipeptidyl peptidase 1 9.3 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150389 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150389&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430840 252824640 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289819 CC(C)Cn1cc(cn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H28FN5O/c1-14(2)12-29-13-18(11-26-29)15-3-4-16(21(24)9-15)7-20(10-25)28-23(30)22-17-5-6-19(8-17)27-22/h3-4,9,11,13-14,17,19-20,22,27H,5-8,12H2,1-2H3,(H,28,30)/t17-,19+,20-,22-/m0/s1 QNSCLBGDVKDDPO-UFGBVDADSA-N 150390 US10238633, Example 64::US8987249, 64::US9713606, 64 Dipeptidyl peptidase 1 9.3 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150390&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430841 252824641 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289820 Cc1c(cnn1C)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H24FN5O/c1-12-18(11-24-27(12)2)13-3-4-14(19(22)9-13)7-17(10-23)26-21(28)20-15-5-6-16(8-15)25-20/h3-4,9,11,15-17,20,25H,5-8H2,1-2H3,(H,26,28)/t15-,16+,17?,20-/m0/s1 BXMGRZWIJVZYAS-YLPFRIKTSA-N 150391 US10238633, Example 65::US8987249, 65 Dipeptidyl peptidase 1 9.4 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150391&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430797 252824642 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289821 COc1ncc(cn1)-c1cn(nn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H23FN8O2/c1-34-23-26-10-15(11-27-23)20-12-32(31-30-20)18-5-3-13(19(24)8-18)6-17(9-25)29-22(33)21-14-2-4-16(7-14)28-21/h3,5,8,10-12,14,16-17,21,28H,2,4,6-7H2,1H3,(H,29,33)/t14-,16+,17-,21-/m0/s1 VYKOEQWAFLBCMG-CCFTVXDOSA-N 150392 US10238633, Example 66::US8987249, 66::US9713606, 66 Dipeptidyl peptidase 1 9.4 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150392 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150392&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937190 252824643 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289822 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-n1cc(nn1)C1CC1 InChI=1S/C21H23FN6O/c22-18-9-17(28-11-19(26-27-28)12-1-2-12)6-4-13(18)7-16(10-23)25-21(29)20-14-3-5-15(8-14)24-20/h4,6,9,11-12,14-16,20,24H,1-3,5,7-8H2,(H,25,29)/t14-,15+,16-,20-/m0/s1 XTPKWAUGRBRSMG-QOIOWGMHSA-N 150393 US10238633, Example 67::US8987249, 67::US9713606, 67 Dipeptidyl peptidase 1 9.6 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150393&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430347 252824644 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289823 CC(C)n1cc(cn1)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H26FN5O/c1-13(2)28-12-17(11-25-28)14-3-4-15(20(23)9-14)7-19(10-24)27-22(29)21-16-5-6-18(8-16)26-21/h3-4,9,11-13,16,18-19,21,26H,5-8H2,1-2H3,(H,27,29)/t16-,18+,19?,21-/m0/s1 KPULTUVWNZBBGM-PLPRGGQXSA-N 150394 US10238633, Example 68::US8987249, 68::US9713606, 68 Dipeptidyl peptidase 1 9.7 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150394&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430348 252824645 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289824 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cn[nH]c1 150395 US10238633, Example 69::US8987249, 69::US9713606, 69 Dipeptidyl peptidase 1 9.9 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150395 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150395&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430323 252824646 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289825 Cn1ncc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C25H24FN5O/c1-31-23-8-14(3-5-16(23)12-28-31)13-2-4-15(21(26)7-13)6-17(11-27)29-25(32)24-20-10-22(30-24)19-9-18(19)20/h2-5,7-8,12,17-20,22,24,30H,6,9-10H2,1H3,(H,29,32)/t17-,18+,19-,20+,22-,24-/m0/s1 QMOYISFVVPPPHT-BMSLZKTOSA-N 150396 US10238633, Example 70::US8987249, 70::US9713606, 70 Dipeptidyl peptidase 1 10.2 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150396 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150396&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430339 252824647 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289826 CCS(=O)(=O)c1ccc(cc1)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H26FN3O3S/c1-2-32(30,31)21-9-6-15(7-10-21)16-3-4-17(22(25)13-16)11-20(14-26)28-24(29)23-18-5-8-19(12-18)27-23/h3-4,6-7,9-10,13,18-20,23,27H,2,5,8,11-12H2,1H3,(H,28,29)/t18-,19+,20?,23-/m0/s1 AERARGOGTDRUGZ-SRDOODBNSA-N 150397 US10238633, Example 71::US8987249, 71::US9713606, 71 Dipeptidyl peptidase 1 10.8 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150397 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150397&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430349 252824648 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289827 CC(=O)c1ccc(s1)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H22FN3O2S/c1-12(27)19-6-7-20(29-19)14-3-2-13(18(23)10-14)8-17(11-24)26-22(28)21-15-4-5-16(9-15)25-21/h2-3,6-7,10,15-17,21,25H,4-5,8-9H2,1H3,(H,26,28)/t15-,16+,17?,21-/m0/s1 RBPTYWDZURRUTK-KWRFEPJMSA-N 150398 US10238633, Example 72::US8987249, 72::US9713606, 72 Dipeptidyl peptidase 1 10.8 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150398&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430316 252824649 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289828 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccco1 InChI=1S/C20H20FN3O2/c21-17-10-13(18-2-1-7-26-18)4-3-12(17)8-16(11-22)24-20(25)19-14-5-6-15(9-14)23-19/h1-4,7,10,14-16,19,23H,5-6,8-9H2,(H,24,25)/t14-,15+,16-,19-/m0/s1 XSWSPBCODWKSAB-RCJHGTSTSA-N 150399 US10238633, Example 73::US8987249, 73::US9713606, 73 Dipeptidyl peptidase 1 11.2 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150399 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150399&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430737 252824650 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289829 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnn(c1)C(=O)C1CCOCC1 InChI=1S/C25H28FN5O3/c26-22-11-16(19-13-28-31(14-19)25(33)15-5-7-34-8-6-15)1-2-17(22)9-21(12-27)30-24(32)23-18-3-4-20(10-18)29-23/h1-2,11,13-15,18,20-21,23,29H,3-10H2,(H,30,32)/t18-,20+,21-,23-/m0/s1 UAHSBFZVBPGAMM-SQMWVJLWSA-N 150400 US10238633, Example 74::US8987249, 74::US9713606, 74 Dipeptidyl peptidase 1 11.4 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150400 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150400&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443238 252824651 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289830 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccccc1 InChI=1S/C22H22FN3O/c23-20-12-15(14-4-2-1-3-5-14)6-7-16(20)10-19(13-24)26-22(27)21-17-8-9-18(11-17)25-21/h1-7,12,17-19,21,25H,8-11H2,(H,26,27)/t17-,18+,19-,21-/m0/s1 OIOPQZQMGBPXIP-JTJHWIPRSA-N 150401 US10238633, Example 75::US8987249, 75::US9713606, 75 Dipeptidyl peptidase 1 11.4 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150401 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150401&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430771 252824652 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289831 CN1Cc2cc(ccc2C1=O)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C25H25FN4O2/c1-30-13-18-8-14(5-7-21(18)25(30)32)15-2-3-16(22(26)11-15)9-20(12-27)29-24(31)23-17-4-6-19(10-17)28-23/h2-3,5,7-8,11,17,19-20,23,28H,4,6,9-10,13H2,1H3,(H,29,31)/t17-,19+,20?,23-/m0/s1 DYVYDWKPJKXISA-GKUGZCSRSA-N 150402 US10238633, Example 76::US8987249, 76::US9713606, 76 Dipeptidyl peptidase 1 11.7 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150402 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150402&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430726 252824653 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289832 COc1ccc(cc1OC)-c1cn(nn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C26H27FN6O3/c1-35-23-8-5-16(11-24(23)36-2)22-14-33(32-31-22)20-7-4-15(21(27)12-20)9-19(13-28)30-26(34)25-17-3-6-18(10-17)29-25/h4-5,7-8,11-12,14,17-19,25,29H,3,6,9-10H2,1-2H3,(H,30,34)/t17-,18+,19-,25-/m0/s1 OSHOVYZSVKRYIM-XMNZWCOLSA-N 150403 US10238633, Example 77::US8987249, 77::US9713606, 77 Dipeptidyl peptidase 1 11.9 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150403 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150403&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90440138 252824654 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289833 Fc1cc(ccc1CC(NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnn(c1)-c1ccccc1 InChI=1S/C25H24FN5O/c26-23-12-16(19-14-28-31(15-19)22-4-2-1-3-5-22)6-7-17(23)10-21(13-27)30-25(32)24-18-8-9-20(11-18)29-24/h1-7,12,14-15,18,20-21,24,29H,8-11H2,(H,30,32)/t18-,20+,21?,24-/m0/s1 DMZSQOLHWTVSKK-VVJUMWPSSA-N 150404 US10238633, Example 78::US8987249, 78::US9713606, 78 Dipeptidyl peptidase 1 12 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150404 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150404&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430773 252824655 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289834 Fc1cc(ccc1CC(NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2NC(=O)Cc2c1 InChI=1S/C24H23FN4O2/c25-20-10-14(13-4-6-21-17(7-13)11-22(30)29-21)1-2-15(20)8-19(12-26)28-24(31)23-16-3-5-18(9-16)27-23/h1-2,4,6-7,10,16,18-19,23,27H,3,5,8-9,11H2,(H,28,31)(H,29,30)/t16-,18+,19?,23-/m0/s1 CWSSERJVIIYICB-KLGBNGAQSA-N 150405 US10238633, Example 79::US8987249, 79::US9713606, 79 Dipeptidyl peptidase 1 12 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150405 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150405&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430606 252824656 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289835 Cc1nc(C)c(s1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H23FN4OS/c1-11-20(28-12(2)24-11)15-4-3-13(18(22)9-15)7-17(10-23)26-21(27)19-14-5-6-16(8-14)25-19/h3-4,9,14,16-17,19,25H,5-8H2,1-2H3,(H,26,27)/t14-,16+,17-,19-/m0/s1 BHLVXHBFLZCTGC-RUENVJTFSA-N 150406 US10238633, Example 80::US8987249, 80::US9713606, 80 Dipeptidyl peptidase 1 12.4 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150406 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150406&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430622 252824657 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289836 CN1C(=O)Cc2ccc(cc12)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(Cl)c1 InChI=1S/C25H25ClN4O2/c1-30-22-11-15(3-5-17(22)12-23(30)31)14-2-4-16(21(26)10-14)8-20(13-27)29-25(32)24-18-6-7-19(9-18)28-24/h2-5,10-11,18-20,24,28H,6-9,12H2,1H3,(H,29,32)/t18-,19+,20?,24-/m0/s1 GNKBVILCETUBCX-BQTZMPSMSA-N 150407 US8987249, 81::US9713606, 81 Dipeptidyl peptidase 1 13.1 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150407 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150407&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430607 252824658 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289837 CCC(C)(O)Cc1cn(nn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H29FN6O2/c1-3-23(2,32)11-18-13-30(29-28-18)19-7-5-14(20(24)10-19)8-17(12-25)27-22(31)21-15-4-6-16(9-15)26-21/h5,7,10,13,15-17,21,26,32H,3-4,6,8-9,11H2,1-2H3,(H,27,31)/t15-,16+,17-,21-,23?/m0/s1 VWKCUYRNWHGYTG-GHBDIUCWSA-N 150408 US10238633, Example 82::US8987249, 82::US9713606, 82 Dipeptidyl peptidase 1 13.1 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150408 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150408&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430623 252824659 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289838 NC(=O)c1ccc(cc1)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H23FN4O2/c24-20-11-15(13-1-3-14(4-2-13)22(26)29)5-6-16(20)9-19(12-25)28-23(30)21-17-7-8-18(10-17)27-21/h1-6,11,17-19,21,27H,7-10H2,(H2,26,29)(H,28,30)/t17-,18+,19?,21-/m0/s1 NQZMPJPNGZQKNA-VHRCFOOQSA-N 150409 US10238633, Example 83::US8987249, 83::US9713606, 83 Dipeptidyl peptidase 1 13.3 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150409 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150409&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430624 252824660 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289839 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-n1cc(nn1)-c1ccc2occc2c1 InChI=1S/C26H23FN6O2/c27-22-12-21(33-14-23(31-32-33)16-3-6-24-17(9-16)7-8-35-24)5-2-15(22)10-20(13-28)30-26(34)25-18-1-4-19(11-18)29-25/h2-3,5-9,12,14,18-20,25,29H,1,4,10-11H2,(H,30,34)/t18-,19+,20-,25-/m0/s1 RGXUCUBHDNKLOH-ZDQHKECQSA-N 150410 US10238633, Example 84::US8987249, 84::US9713606, 84 Dipeptidyl peptidase 1 13.7 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150410 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150410&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430617 252824661 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289840 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccsc1C#N InChI=1S/C21H19FN4OS/c22-18-9-12(17-5-6-28-19(17)11-24)1-2-13(18)7-16(10-23)26-21(27)20-14-3-4-15(8-14)25-20/h1-2,5-6,9,14-16,20,25H,3-4,7-8H2,(H,26,27)/t14-,15+,16-,20-/m0/s1 JBFGXPGASYJVIZ-QOIOWGMHSA-N 150411 US10238633, Example 85::US8987249, 85::US9713606, 85 Dipeptidyl peptidase 1 14 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150411 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150411&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430798 252824662 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289841 CS(=O)(=O)c1ccc(c(F)c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H23F2N3O3S/c1-32(30,31)18-6-7-19(21(25)11-18)13-2-3-14(20(24)10-13)8-17(12-26)28-23(29)22-15-4-5-16(9-15)27-22/h2-3,6-7,10-11,15-17,22,27H,4-5,8-9H2,1H3,(H,28,29)/t15-,16+,17-,22-/m0/s1 OPAJMLXYCWWNLW-GEYWLOKFSA-N 150412 US10238633, Example 86::US8987249, 86::US9713606, 86 Dipeptidyl peptidase 1 14.1 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150412 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150412&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430868 252824663 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289842 COCC(=O)n1cc(cn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H24FN5O3/c1-31-12-20(29)28-11-16(10-25-28)13-2-3-14(19(23)8-13)6-18(9-24)27-22(30)21-15-4-5-17(7-15)26-21/h2-3,8,10-11,15,17-18,21,26H,4-7,12H2,1H3,(H,27,30)/t15-,17+,18-,21-/m0/s1 SCGDLXUAKULUFJ-DKXUYOFUSA-N 150413 US10238633, Example 87::US8987249, 87::US9713606, 87 Dipeptidyl peptidase 1 14.2 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150413 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150413&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443239 252824664 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289843 CS(=O)(=O)c1cccc(c1)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H24FN3O3S/c1-31(29,30)20-4-2-3-14(11-20)15-5-6-16(21(24)12-15)9-19(13-25)27-23(28)22-17-7-8-18(10-17)26-22/h2-6,11-12,17-19,22,26H,7-10H2,1H3,(H,27,28)/t17-,18+,19?,22-/m0/s1 SLANNUBDKTXJNP-HJKBJPMPSA-N 150414 US10238633, Example 88::US8987249, 88::US9713606, 88 Dipeptidyl peptidase 1 15.2 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150414 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150414&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430806 252824665 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289844 CCC(O)Cc1cn(nn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H27FN6O2/c1-2-19(30)9-17-12-29(28-27-17)18-6-4-13(20(23)10-18)7-16(11-24)26-22(31)21-14-3-5-15(8-14)25-21/h4,6,10,12,14-16,19,21,25,30H,2-3,5,7-9H2,1H3,(H,26,31)/t14-,15+,16-,19?,21-/m0/s1 QBYQWVRYHRNFFO-NUDGSJNLSA-N 150415 US10238633, Example 89::US8987249, 89::US9713606, 89 Dipeptidyl peptidase 1 15.6 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150415&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430796 252824666 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289845 CC(=O)c1cn(nn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C20H21FN6O2/c1-11(28)18-10-27(26-25-18)16-5-3-12(17(21)8-16)6-15(9-22)24-20(29)19-13-2-4-14(7-13)23-19/h3,5,8,10,13-15,19,23H,2,4,6-7H2,1H3,(H,24,29)/t13-,14+,15-,19-/m0/s1 JCEDMPSWCYIJPG-YGTYGHESSA-N 150416 US10238633, Example 90::US8987249, 90::US9713606, 90 Dipeptidyl peptidase 1 16 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150416 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150416&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430807 252824667 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289846 CS(=O)(=O)N1CCN(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H28FN5O3S/c1-31(29,30)27-8-6-26(7-9-27)18-5-3-14(19(22)12-18)10-17(13-23)25-21(28)20-15-2-4-16(11-15)24-20/h3,5,12,15-17,20,24H,2,4,6-11H2,1H3,(H,25,28)/t15-,16+,17-,20-/m0/s1 YKWPCSVFBUCYCD-CLWJZODNSA-N 150417 US10238633, Example 91::US8987249, 91::US9713606, 91 Dipeptidyl peptidase 1 17 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150417 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150417&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430749 252824668 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289847 Cc1occc1-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H22FN3O2/c1-12-18(6-7-27-12)13-2-3-14(19(22)10-13)8-17(11-23)25-21(26)20-15-4-5-16(9-15)24-20/h2-3,6-7,10,15-17,20,24H,4-5,8-9H2,1H3,(H,25,26)/t15-,16+,17?,20-/m0/s1 SJILLKINMISQMS-YLPFRIKTSA-N 150418 US10238633, Example 92::US8987249, 92 Dipeptidyl peptidase 1 17.7 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150418&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430791 252824669 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289848 Cc1ncc(s1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C21H21FN4OS/c1-10-24-9-19(28-10)12-3-2-11(17(22)5-12)4-13(8-23)25-21(27)20-16-7-18(26-20)15-6-14(15)16/h2-3,5,9,13-16,18,20,26H,4,6-7H2,1H3,(H,25,27)/t13-,14+,15-,16+,18-,20-/m0/s1 XTPZCJCPIUDBMC-SHIIKYBRSA-N 150419 US10238633, Example 93::US8987249, 93::US9713606, 93 Dipeptidyl peptidase 1 18.3 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150419 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150419&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430767 252824670 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289849 COc1cccc(c1)-c1cn(nn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C25H25FN6O2/c1-34-21-4-2-3-16(11-21)23-14-32(31-30-23)20-8-6-15(22(26)12-20)9-19(13-27)29-25(33)24-17-5-7-18(10-17)28-24/h2-4,6,8,11-12,14,17-19,24,28H,5,7,9-10H2,1H3,(H,29,33)/t17-,18+,19-,24-/m0/s1 BVKSOIQSAWREHK-YDLHNXBPSA-N 150420 US10238633, Example 94::US8987249, 94::US9713606, 94 Dipeptidyl peptidase 1 18.7 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150420 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150420&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430792 252824671 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289850 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2CNC(=O)c2c1 InChI=1S/C24H23FN4O2/c25-21-10-14(13-2-4-17-12-27-23(30)20(17)9-13)1-3-15(21)7-19(11-26)29-24(31)22-16-5-6-18(8-16)28-22/h1-4,9-10,16,18-19,22,28H,5-8,12H2,(H,27,30)(H,29,31)/t16-,18+,19-,22-/m0/s1 YVPAYTOMTQVUAC-ZBPHCFQXSA-N 150421 US10238633, Example 95::US8987249, 95::US9713606, 95 Dipeptidyl peptidase 1 19.2 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150421 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150421&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430778 252824672 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289851 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cc(no1)-c1ccccc1 InChI=1S/C25H23FN4O2/c26-21-12-17(23-13-22(30-32-23)15-4-2-1-3-5-15)7-6-16(21)10-20(14-27)29-25(31)24-18-8-9-19(11-18)28-24/h1-7,12-13,18-20,24,28H,8-11H2,(H,29,31)/t18-,19+,20-,24-/m0/s1 QESWGIWAZDKMDD-VKDGWMQASA-N 150422 US10238633, Example 96::US8987249, 96::US9713606, 96 Dipeptidyl peptidase 1 19.8 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150422 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150422&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430750 252824673 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289852 COCCn1cc(cn1)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H26FN5O2/c1-30-7-6-28-13-17(12-25-28)14-2-3-15(20(23)10-14)8-19(11-24)27-22(29)21-16-4-5-18(9-16)26-21/h2-3,10,12-13,16,18-19,21,26H,4-9H2,1H3,(H,27,29)/t16-,18+,19?,21-/m0/s1 IQMJMZXJSJWJBP-PLPRGGQXSA-N 150423 US10238633, Example 97::US8987249, 97::US9713606, 97 Dipeptidyl peptidase 1 19.9 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150423 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150423&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430842 252824674 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289853 Fc1cc(ccc1CC(NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ncc(Cl)cn1 InChI=1S/C20H19ClFN5O/c21-14-9-24-19(25-10-14)13-2-1-11(17(22)7-13)5-16(8-23)27-20(28)18-12-3-4-15(6-12)26-18/h1-2,7,9-10,12,15-16,18,26H,3-6H2,(H,27,28)/t12-,15+,16?,18-/m0/s1 AKPGVXYITPFJOW-UDOSGHBDSA-N 150424 US10238633, Example 98::US8987249, 98::US9713606, 98 Dipeptidyl peptidase 1 20.3 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150424 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150424&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430870 252824675 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289854 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-n1cc(CCN2CCOCC2)nn1 InChI=1S/C24H30FN7O2/c25-22-13-21(32-15-19(29-30-32)5-6-31-7-9-34-10-8-31)4-2-16(22)11-20(14-26)28-24(33)23-17-1-3-18(12-17)27-23/h2,4,13,15,17-18,20,23,27H,1,3,5-12H2,(H,28,33)/t17-,18+,20-,23-/m0/s1 MYILWBBNYUAXDA-KQZHTCIUSA-N 150425 US10238633, Example 99::US8987249, 99::US9713606, 99 Dipeptidyl peptidase 1 21.1 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150425 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150425&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937191 252824676 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289855 Cn1nc(cc1-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1)C(F)(F)F InChI=1S/C21H21F4N5O/c1-30-17(9-18(29-30)21(23,24)25)12-3-2-11(16(22)8-12)6-15(10-26)28-20(31)19-13-4-5-14(7-13)27-19/h2-3,8-9,13-15,19,27H,4-7H2,1H3,(H,28,31)/t13-,14+,15-,19-/m0/s1 MYYLJSMDWKTSJL-YGTYGHESSA-N 150426 US10238633, Example 100::US8987249, 100::US9713606, 100 Dipeptidyl peptidase 1 22.3 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150426 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150426&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430809 252824677 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289856 CC(O)Cc1cn(nn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H25FN6O2/c1-12(29)6-17-11-28(27-26-17)18-5-3-13(19(22)9-18)7-16(10-23)25-21(30)20-14-2-4-15(8-14)24-20/h3,5,9,11-12,14-16,20,24,29H,2,4,6-8H2,1H3,(H,25,30)/t12?,14-,15+,16-,20-/m0/s1 CMGDKMRQSURTJI-VPRMXFSVSA-N 150427 US10238633, Example 101::US8987249, 101::US9713606, 101 Dipeptidyl peptidase 1 23.9 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150427 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150427&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430871 252824678 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289857 Fc1cc(ccc1CC(NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnc(Cl)cn1 InChI=1S/C20H19ClFN5O/c21-18-10-24-17(9-25-18)12-2-1-11(16(22)7-12)5-15(8-23)27-20(28)19-13-3-4-14(6-13)26-19/h1-2,7,9-10,13-15,19,26H,3-6H2,(H,27,28)/t13-,14+,15?,19-/m0/s1 JGOVHYJPZVPVCA-FKGKKHCZSA-N 150428 US10238633, Example 102::US8987249, 102::US9713606, 102 Dipeptidyl peptidase 1 24.8 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150428 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150428&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430843 252824679 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289858 Fc1cc(ccc1CC(NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccoc1 InChI=1S/C20H20FN3O2/c21-18-9-12(15-5-6-26-11-15)1-2-13(18)7-17(10-22)24-20(25)19-14-3-4-16(8-14)23-19/h1-2,5-6,9,11,14,16-17,19,23H,3-4,7-8H2,(H,24,25)/t14-,16+,17?,19-/m0/s1 BNIARBLPIAJFIM-QSBFGILCSA-N 150429 US10238633, Example 103::US8987249, 103::US9713606, 103 Dipeptidyl peptidase 1 24.9 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150429 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150429&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430384 252824680 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289859 Cc1n[nH]cc1-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 150430 US10238633, Example 104::US8987249, 104::US9713606, 104 Dipeptidyl peptidase 1 24.9 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150430 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150430&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430365 252824681 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289860 CCOCc1cn(nn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H25FN6O2/c1-2-30-12-17-11-28(27-26-17)18-6-4-13(19(22)9-18)7-16(10-23)25-21(29)20-14-3-5-15(8-14)24-20/h4,6,9,11,14-16,20,24H,2-3,5,7-8,12H2,1H3,(H,25,29)/t14-,15+,16-,20-/m0/s1 ABSBTIIBDKCMEG-QOIOWGMHSA-N 150431 US10238633, Example 105::US8987249, 105::US9713606, 105 Dipeptidyl peptidase 1 25 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150431 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150431&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430366 252824682 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289861 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-n1cc(COC(=O)N2CCCC2)nn1 InChI=1S/C24H28FN7O3/c25-21-11-20(32-13-19(29-30-32)14-35-24(34)31-7-1-2-8-31)6-4-15(21)9-18(12-26)28-23(33)22-16-3-5-17(10-16)27-22/h4,6,11,13,16-18,22,27H,1-3,5,7-10,14H2,(H,28,33)/t16-,17+,18-,22-/m0/s1 SCQBGLUSDQKNSV-SUWCGCSTSA-N 150432 US10238633, Example 106::US8987249, 106::US9713606, 106 Dipeptidyl peptidase 1 25.9 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150432&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430334 252824683 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289862 Cn1c2ccc(cc2oc1=O)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H23FN4O3/c1-29-20-7-5-14(11-21(20)32-24(29)31)13-2-3-15(19(25)10-13)8-18(12-26)28-23(30)22-16-4-6-17(9-16)27-22/h2-3,5,7,10-11,16-18,22,27H,4,6,8-9H2,1H3,(H,28,30)/t16-,17+,18?,22-/m0/s1 HSOUISMKPAKWDA-QOPFVKLFSA-N 150433 US10238633, Example 107::US8987249, 107::US9713606, 107 Dipeptidyl peptidase 1 25.9 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150433 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150433&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430367 252824684 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289863 Fc1cc(ccc1CC(NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc(Cl)nn1 InChI=1S/C20H19ClFN5O/c21-18-6-5-17(26-27-18)12-2-1-11(16(22)9-12)7-15(10-23)25-20(28)19-13-3-4-14(8-13)24-19/h1-2,5-6,9,13-15,19,24H,3-4,7-8H2,(H,25,28)/t13-,14+,15?,19-/m0/s1 HEBPAARTHZGYLM-FKGKKHCZSA-N 150434 US10238633, Example 108::US8987249, 108::US9713606, 108 Dipeptidyl peptidase 1 26.4 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150434 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150434&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430436 252824685 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289864 CC(C)C(O)Cc1cn(nn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H29FN6O2/c1-13(2)21(31)9-18-12-30(29-28-18)19-6-4-14(20(24)10-19)7-17(11-25)27-23(32)22-15-3-5-16(8-15)26-22/h4,6,10,12-13,15-17,21-22,26,31H,3,5,7-9H2,1-2H3,(H,27,32)/t15-,16+,17-,21?,22-/m0/s1 WYCZQJCBELHBNC-UBQHZJADSA-N 150435 US10238633, Example 109::US8987249, 109::US9713606, 109 Dipeptidyl peptidase 1 26.9 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150435 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150435&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430391 252824686 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289865 CCn1nccc1-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H24FN5O/c1-2-27-19(7-8-24-27)14-4-3-13(18(22)11-14)9-17(12-23)26-21(28)20-15-5-6-16(10-15)25-20/h3-4,7-8,11,15-17,20,25H,2,5-6,9-10H2,1H3,(H,26,28)/t15-,16+,17-,20-/m0/s1 IHPAWNTVVZQHFV-CLWJZODNSA-N 150436 US10238633, Example 110::US8987249, 110::US9713606, 110 Dipeptidyl peptidase 1 28.6 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150436 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150436&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430785 252824687 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289866 COCc1cn(nn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C20H23FN6O2/c1-29-11-16-10-27(26-25-16)17-5-3-12(18(21)8-17)6-15(9-22)24-20(28)19-13-2-4-14(7-13)23-19/h3,5,8,10,13-15,19,23H,2,4,6-7,11H2,1H3,(H,24,28)/t13-,14+,15-,19-/m0/s1 YUYZMIRSJWARNU-YGTYGHESSA-N 150437 US10238633, Example 111::US8987249, 111::US9713606, 111 Dipeptidyl peptidase 1 31.8 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150437 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150437&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430786 252824688 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289867 COCCOCc1cn(nn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H27FN6O3/c1-31-6-7-32-13-18-12-29(28-27-18)19-5-3-14(20(23)10-19)8-17(11-24)26-22(30)21-15-2-4-16(9-15)25-21/h3,5,10,12,15-17,21,25H,2,4,6-9,13H2,1H3,(H,26,30)/t15-,16+,17-,21-/m0/s1 ZUVPKRLLJRNURX-DLRJPAPCSA-N 150438 US10238633, Example 112::US8987249, 112::US9713606, 112 Dipeptidyl peptidase 1 33.3 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150438 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150438&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90440140 252824689 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289868 CCc1ncc(s1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C22H23FN4OS/c1-2-20-25-10-19(29-20)12-4-3-11(17(23)6-12)5-13(9-24)26-22(28)21-16-8-18(27-21)15-7-14(15)16/h3-4,6,10,13-16,18,21,27H,2,5,7-8H2,1H3,(H,26,28)/t13-,14+,15-,16+,18-,21-/m0/s1 MBNDRKVILGAANK-OAXXGVFQSA-N 150439 US10238633, Example 113::US8987249, 113::US9713606, 113 Dipeptidyl peptidase 1 36.4 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150439 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150439&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430779 252824690 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289869 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cc[nH]n1 150440 US10238633, Example 114::US8987249, 114::US9713606, 114 Dipeptidyl peptidase 1 36.7 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150440 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150440&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430751 252824691 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289870 OC(=O)c1ccc(s1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H20FN3O3S/c22-16-9-12(17-5-6-18(29-17)21(27)28)2-1-11(16)7-15(10-23)25-20(26)19-13-3-4-14(8-13)24-19/h1-2,5-6,9,13-15,19,24H,3-4,7-8H2,(H,25,26)(H,27,28)/t13-,14+,15-,19-/m0/s1 UKXCOIVMRZGJFO-YGTYGHESSA-N 150441 US10238633, Example 115::US8987249, 115::US9713606, 115 Dipeptidyl peptidase 1 37.8 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150441&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430738 252824692 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289871 Fc1cc(ccc1CC(NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnn(c1)C1CCOCC1 InChI=1S/C24H28FN5O2/c25-22-11-15(18-13-27-30(14-18)21-5-7-32-8-6-21)1-2-16(22)9-20(12-26)29-24(31)23-17-3-4-19(10-17)28-23/h1-2,11,13-14,17,19-21,23,28H,3-10H2,(H,29,31)/t17-,19+,20?,23-/m0/s1 BPAHCPXZVBMFNE-GKUGZCSRSA-N 150442 US10238633, Example 116::US8987249, 116::US9713606, 116 Dipeptidyl peptidase 1 39.1 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150442 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150442&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430739 252824693 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289872 CN1CCC(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H29FN4O/c1-27-8-6-14(7-9-27)15-2-3-16(20(23)12-15)10-19(13-24)26-22(28)21-17-4-5-18(11-17)25-21/h2-3,12,14,17-19,21,25H,4-11H2,1H3,(H,26,28)/t17-,18+,19-,21-/m0/s1 HNBAKPJBZUSZLD-JTJHWIPRSA-N 150443 US10238633, Example 117::US8987249, 117::US9713606, 117 Dipeptidyl peptidase 1 39.6 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150443&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430745 252824694 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289873 Cn1cc(c(n1)C(F)(F)F)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H21F4N5O/c1-30-10-16(19(29-30)21(23,24)25)11-2-3-12(17(22)8-11)6-15(9-26)28-20(31)18-13-4-5-14(7-13)27-18/h2-3,8,10,13-15,18,27H,4-7H2,1H3,(H,28,31)/t13-,14+,15-,18-/m0/s1 ZEAZPEMJKLJBFP-KRXQYRFLSA-N 150444 US10238633, Example 118::US8987249, 118::US9713606, 118 Dipeptidyl peptidase 1 44.3 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150444 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150444&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430604 252824695 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289874 COc1ccccc1-c1cn(nn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C25H25FN6O2/c1-34-23-5-3-2-4-20(23)22-14-32(31-30-22)19-9-7-15(21(26)12-19)10-18(13-27)29-25(33)24-16-6-8-17(11-16)28-24/h2-5,7,9,12,14,16-18,24,28H,6,8,10-11H2,1H3,(H,29,33)/t16-,17+,18-,24-/m0/s1 FMWUNAUOLVVZHN-AIDSWVIKSA-N 150445 US10238633, Example 119::US8987249, 119::US9713606, 119 Dipeptidyl peptidase 1 51.2 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150445&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90440141 252824696 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289875 CN1C(=O)Cc2ccc(cc12)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(O)c1 InChI=1S/C25H26N4O3/c1-29-21-10-14(2-4-16(21)12-23(29)31)15-3-5-17(22(30)11-15)8-20(13-26)28-25(32)24-18-6-7-19(9-18)27-24/h2-5,10-11,18-20,24,27,30H,6-9,12H2,1H3,(H,28,32)/t18-,19+,20?,24-/m0/s1 YXZHSQPRBJFDQC-BQTZMPSMSA-N 150446 US10238633, Example 120::US8987249, 120::US9713606, 120 Dipeptidyl peptidase 1 55.6 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150446&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430568 252824697 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289876 Cc1noc(C)c1-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H23FN4O2/c1-11-19(12(2)28-26-11)14-4-3-13(18(22)9-14)7-17(10-23)25-21(27)20-15-5-6-16(8-15)24-20/h3-4,9,15-17,20,24H,5-8H2,1-2H3,(H,25,27)/t15-,16+,17-,20-/m0/s1 PHUAZJBZKNQTIM-CLWJZODNSA-N 150447 US10238633, Example 121::US8987249, 121::US9713606, 121 Dipeptidyl peptidase 1 156.5 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150447&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430644 252824698 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289877 CN1C(=O)Cc2ccc(cc12)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(OCc2ccccc2)c1 InChI=1S/C32H32N4O3/c1-36-28-15-21(7-9-23(28)17-30(36)37)22-8-10-24(29(16-22)39-19-20-5-3-2-4-6-20)13-27(18-33)35-32(38)31-25-11-12-26(14-25)34-31/h2-10,15-16,25-27,31,34H,11-14,17,19H2,1H3,(H,35,38)/t25-,26+,27?,31-/m0/s1 VGNUUKUQMUQSQR-NKFYVHBOSA-N 150448 US10238633, Example 122::US8987249, 122::US9713606, 122 Dipeptidyl peptidase 1 181.7 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150448&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430655 252824699 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289878 O=C(NC(Cc1ccc2c(c1)[nH]c(=O)c1ccccc21)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 150449 US10238633, Example 123::US8987249, 123::US9713606, 123 Dipeptidyl peptidase 1 186.6 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150449 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150449&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937192 252824700 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289880 CN1CCN(C(=O)C1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H26FN5O2/c1-26-6-7-27(19(28)12-26)17-5-3-13(18(22)10-17)8-16(11-23)25-21(29)20-14-2-4-15(9-14)24-20/h3,5,10,14-16,20,24H,2,4,6-9,12H2,1H3,(H,25,29)/t14-,15+,16-,20-/m0/s1 HXBNPWRCCJXQEN-QOIOWGMHSA-N 150451 US10238633, Example 125::US8987249, 125::US9713606, 125 Dipeptidyl peptidase 1 206 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150451 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150451&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430608 252824702 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289881 Cc1cnn(C)c1-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H24FN5O/c1-12-11-24-27(2)20(12)15-4-3-13(18(22)9-15)7-17(10-23)26-21(28)19-14-5-6-16(8-14)25-19/h3-4,9,11,14,16-17,19,25H,5-8H2,1-2H3,(H,26,28)/t14-,16+,17-,19-/m0/s1 FIDRPXYSWGIXNB-RUENVJTFSA-N 150452 US10238633, Example 126::US8987249, 126::US9713606, 126 Dipeptidyl peptidase 1 275.1 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150452 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150452&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430625 252824703 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289882 O=C(NC(Cc1ccc2cn[nH]c2c1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 150453 US10238633, Example 127::US8987249, 127::US9713606, 127 Dipeptidyl peptidase 1 859.7 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150453 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150453&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430742 252824704 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289883 O=C(NC(Cc1cccc2[nH]c(=O)c3ccccc3c12)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 150454 US10238633, Example 128::US8987249, 128::US9713606, 128 Dipeptidyl peptidase 1 2393 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150454 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150454&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937193 252824705 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289884 Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C25H23FN4O3/c1-30-21-8-13(4-5-22(21)33-25(30)32)12-2-3-14(19(26)7-12)6-15(11-27)28-24(31)23-18-10-20(29-23)17-9-16(17)18/h2-5,7-8,15-18,20,23,29H,6,9-10H2,1H3,(H,28,31)/t15-,16+,17-,18+,20-,23-/m0/s1 FUXYTNBGQFZKOD-MPYHZQTKSA-N 150455 US10238633, Example 129::US8987249, 129::US9713606, 129 Dipeptidyl peptidase 1 82.7 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150455 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150455&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90440142 252824706 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289885 NC(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C24H23FN4O2/c25-20-8-14(12-1-3-13(4-2-12)23(27)30)5-6-15(20)7-16(11-26)28-24(31)22-19-10-21(29-22)18-9-17(18)19/h1-6,8,16-19,21-22,29H,7,9-10H2,(H2,27,30)(H,28,31)/t16-,17+,18-,19+,21-,22-/m0/s1 XBPOSPXPHLIHFW-RVEDGADZSA-N 150456 US10238633, Example 130::US8987249, 130::US9713606, 130 Dipeptidyl peptidase 1 43.5 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150456 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150456&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430390 252824707 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289886 CC(=O)Nc1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C25H25FN4O2/c1-13(31)28-17-6-4-14(5-7-17)15-2-3-16(22(26)9-15)8-18(12-27)29-25(32)24-21-11-23(30-24)20-10-19(20)21/h2-7,9,18-21,23-24,30H,8,10-11H2,1H3,(H,28,31)(H,29,32)/t18-,19+,20-,21+,23-,24-/m0/s1 SJDNSJYCAUFUFP-KXNGWZAWSA-N 150457 US10238633, Example 131::US8987249, 131::US9713606, 131 Dipeptidyl peptidase 1 138.7 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150457 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150457&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430333 252824708 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289887 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@H]2C[C@@H]1[C@@H]1C[C@H]21)C#N)-c1ccc(C#N)c(F)c1 InChI=1S/C24H20F2N4O/c25-20-6-12(13-2-4-15(10-27)21(26)7-13)1-3-14(20)5-16(11-28)29-24(31)23-19-9-22(30-23)18-8-17(18)19/h1-4,6-7,16-19,22-23,30H,5,8-9H2,(H,29,31)/t16-,17+,18-,19+,22-,23-/m0/s1 VUMXUAUWTBHETB-SFJJLGKISA-N 150458 US10238633, Example 132::US8987249, 132::US9713606, 132 Dipeptidyl peptidase 1 18.9 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150458&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430755 252824709 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289888 COC(=O)c1cc(cs1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C23H22FN3O3S/c1-30-23(29)20-6-13(10-31-20)11-2-3-12(18(24)5-11)4-14(9-25)26-22(28)21-17-8-19(27-21)16-7-15(16)17/h2-3,5-6,10,14-17,19,21,27H,4,7-8H2,1H3,(H,26,28)/t14-,15+,16-,17+,19-,21-/m0/s1 YCGQHGQZFQYOAZ-TXQSJXHQSA-N 150459 US10238633, Example 133::US8987249, 133::US9713606, 133 Dipeptidyl peptidase 1 16.1 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150459&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90440143 252824710 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289889 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@H]2C[C@@H]1[C@@H]1C[C@H]21)C#N)-c1ccc2NC(=O)Cc2c1 InChI=1S/C25H23FN4O2/c26-20-7-13(12-3-4-21-15(5-12)8-23(31)29-21)1-2-14(20)6-16(11-27)28-25(32)24-19-10-22(30-24)18-9-17(18)19/h1-5,7,16-19,22,24,30H,6,8-10H2,(H,28,32)(H,29,31)/t16-,17+,18-,19+,22-,24-/m0/s1 BPBLBLWVDZTDMM-LADXIUKTSA-N 150460 US10238633, Example 134::US8987249, 134::US9713606, 134 Dipeptidyl peptidase 1 17.8 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150460 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150460&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430759 252824711 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289890 Cn1cc2ccc(cc2n1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C25H24FN5O/c1-31-12-16-5-3-14(8-22(16)30-31)13-2-4-15(21(26)7-13)6-17(11-27)28-25(32)24-20-10-23(29-24)19-9-18(19)20/h2-5,7-8,12,17-20,23-24,29H,6,9-10H2,1H3,(H,28,32)/t17-,18+,19-,20+,23-,24-/m0/s1 OIWYRYIPQPDPIM-XJMWNJKVSA-N 150461 US10238633, Example 135::US8987249, 135::US9713606, 135 Dipeptidyl peptidase 1 285.7 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150461 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150461&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430782 252824712 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289891 NS(=O)(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C23H23FN4O3S/c24-20-8-13(12-3-5-16(6-4-12)32(26,30)31)1-2-14(20)7-15(11-25)27-23(29)22-19-10-21(28-22)18-9-17(18)19/h1-6,8,15,17-19,21-22,28H,7,9-10H2,(H,27,29)(H2,26,30,31)/t15-,17+,18-,19+,21-,22-/m0/s1 KQPFXAKCEUMOIW-LNHKNWPKSA-N 150462 US10238633, Example 136::US8987249, 136::US9713606, 136 Dipeptidyl peptidase 1 10.2 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150462 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150462&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937194 252824713 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289892 Cn1ncc2cc(ccc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C25H24FN5O/c1-31-23-5-4-13(6-16(23)12-28-31)14-2-3-15(21(26)8-14)7-17(11-27)29-25(32)24-20-10-22(30-24)19-9-18(19)20/h2-6,8,12,17-20,22,24,30H,7,9-10H2,1H3,(H,29,32)/t17-,18+,19-,20+,22-,24-/m0/s1 CHXQHZPGIICLSV-BMSLZKTOSA-N 150463 US10238633, Example 137::US8987249, 137::US9713606, 137 Dipeptidyl peptidase 1 59.7 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150463 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150463&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430204 252824714 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289893 CCn1cc(cn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C22H24FN5O/c1-2-28-11-14(10-25-28)12-3-4-13(19(23)6-12)5-15(9-24)26-22(29)21-18-8-20(27-21)17-7-16(17)18/h3-4,6,10-11,15-18,20-21,27H,2,5,7-8H2,1H3,(H,26,29)/t15-,16+,17-,18+,20-,21-/m0/s1 AOKRMUHLKCKEIK-FJEWGBTGSA-N 150464 US10238633, Example 138::US8987249, 138::US9713606, 138 Dipeptidyl peptidase 1 14.5 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150464 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150464&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430254 252824715 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289894 CS(=O)(=O)Nc1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C24H25FN4O3S/c1-33(31,32)29-16-4-2-3-13(7-16)14-5-6-15(21(25)9-14)8-17(12-26)27-24(30)23-20-11-22(28-23)19-10-18(19)20/h2-7,9,17-20,22-23,28-29H,8,10-11H2,1H3,(H,27,30)/t17-,18+,19-,20+,22-,23-/m0/s1 XHJXZNFMYRTAPM-IYDLXWBISA-N 150465 US10238633, Example 139::US8987249, 139::US9713606, 139 Dipeptidyl peptidase 1 11.7 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150465 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150465&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937195 252824716 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289895 CS(=O)(=O)Nc1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C24H25FN4O3S/c1-33(31,32)29-16-6-4-13(5-7-16)14-2-3-15(21(25)9-14)8-17(12-26)27-24(30)23-20-11-22(28-23)19-10-18(19)20/h2-7,9,17-20,22-23,28-29H,8,10-11H2,1H3,(H,27,30)/t17-,18+,19-,20+,22-,23-/m0/s1 BCAZJKORVAFQTP-IYDLXWBISA-N 150466 US10238633, Example 140::US8987249, 140::US9713606, 140 Dipeptidyl peptidase 1 21.5 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150466 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150466&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430222 252824717 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289896 CS(=O)(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C24H24FN3O3S/c1-32(30,31)17-6-4-13(5-7-17)14-2-3-15(21(25)9-14)8-16(12-26)27-24(29)23-20-11-22(28-23)19-10-18(19)20/h2-7,9,16,18-20,22-23,28H,8,10-11H2,1H3,(H,27,29)/t16-,18+,19-,20+,22-,23-/m0/s1 UYWCFMFTAPJUIH-VUPWWPOFSA-N 150467 US10238633, Example 141::US8987249, 141::US9713606, 141 Dipeptidyl peptidase 1 36.6 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150467 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150467&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90440144 252824718 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289897 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@H]2C[C@@H]1[C@@H]1C[C@H]21)C#N)-c1ccc(nc1)C#N InChI=1S/C23H20FN5O/c24-20-6-12(14-3-4-15(9-25)27-11-14)1-2-13(20)5-16(10-26)28-23(30)22-19-8-21(29-22)18-7-17(18)19/h1-4,6,11,16-19,21-22,29H,5,7-8H2,(H,28,30)/t16-,17+,18-,19+,21-,22-/m0/s1 XEYBRPMUORQYDN-RVEDGADZSA-N 150468 US10238633, Example 142::US8987249, 142::US9713606, 142 Dipeptidyl peptidase 1 63.1 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150468 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150468&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430618 252824719 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289898 NS(=O)(=O)c1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C23H23FN4O3S/c24-20-8-13(12-2-1-3-16(7-12)32(26,30)31)4-5-14(20)6-15(11-25)27-23(29)22-19-10-21(28-22)18-9-17(18)19/h1-5,7-8,15,17-19,21-22,28H,6,9-10H2,(H,27,29)(H2,26,30,31)/t15-,17+,18-,19+,21-,22-/m0/s1 FWBVDUGYEFVZSF-LNHKNWPKSA-N 150469 US10238633, Example 143::US8987249, 143::US9713606, 143 Dipeptidyl peptidase 1 6.7 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150469 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150469&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430485 252824720 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289899 CS(=O)(=O)c1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C24H24FN3O3S/c1-32(30,31)17-4-2-3-13(8-17)14-5-6-15(21(25)9-14)7-16(12-26)27-24(29)23-20-11-22(28-23)19-10-18(19)20/h2-6,8-9,16,18-20,22-23,28H,7,10-11H2,1H3,(H,27,29)/t16-,18+,19-,20+,22-,23-/m0/s1 YEGLUNIHKAHCKL-VUPWWPOFSA-N 150470 US10238633, Example 144::US8987249, 144::US9713606, 144 Dipeptidyl peptidase 1 26.3 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150470 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150470&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430627 252824721 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289900 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@H]2C[C@@H]1[C@@H]1C[C@H]21)C#N)-c1ccc(Cl)nc1 InChI=1S/C22H20ClFN4O/c23-20-4-3-13(10-26-20)11-1-2-12(18(24)6-11)5-14(9-25)27-22(29)21-17-8-19(28-21)16-7-15(16)17/h1-4,6,10,14-17,19,21,28H,5,7-8H2,(H,27,29)/t14-,15+,16-,17+,19-,21-/m0/s1 ZGRYOFAIQXJOSA-TXQSJXHQSA-N 150471 US10238633, Example 145::US8987249, 145::US9713606, 145 Dipeptidyl peptidase 1 53.8 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150471 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150471&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430628 252824722 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289901 NC(=O)c1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C24H23FN4O2/c25-20-8-13(12-2-1-3-15(6-12)23(27)30)4-5-14(20)7-16(11-26)28-24(31)22-19-10-21(29-22)18-9-17(18)19/h1-6,8,16-19,21-22,29H,7,9-10H2,(H2,27,30)(H,28,31)/t16-,17+,18-,19+,21-,22-/m0/s1 MVZGYAKRZLZBEL-RVEDGADZSA-N 150472 US10238633, Example 146::US8987249, 146::US9713606, 146 Dipeptidyl peptidase 1 30.5 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150472 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150472&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430629 252824723 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289902 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@H]2C[C@@H]1[C@@H]1C[C@H]21)C#N)-c1ccc2C(=O)NCc2c1 InChI=1S/C25H23FN4O2/c26-21-7-13(12-3-4-17-15(5-12)11-28-24(17)31)1-2-14(21)6-16(10-27)29-25(32)23-20-9-22(30-23)19-8-18(19)20/h1-5,7,16,18-20,22-23,30H,6,8-9,11H2,(H,28,31)(H,29,32)/t16-,18+,19-,20+,22-,23-/m0/s1 XGTPTZPXCXMRBF-VUPWWPOFSA-N 150473 US10238633, Example 147::US8987249, 147::US9713606, 147 Dipeptidyl peptidase 1 6.2 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150473 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150473&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430679 252824724 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289903 Fc1cc(ccc1CC(NC(=O)[C@H]1N[C@H]2C[C@@H]1[C@@H]1C[C@H]21)C#N)-c1ccc2C(=O)NCCc2c1 InChI=1S/C26H25FN4O2/c27-22-9-14(13-3-4-18-15(7-13)5-6-29-25(18)32)1-2-16(22)8-17(12-28)30-26(33)24-21-11-23(31-24)20-10-19(20)21/h1-4,7,9,17,19-21,23-24,31H,5-6,8,10-11H2,(H,29,32)(H,30,33)/t17?,19-,20+,21-,23+,24+/m1/s1 KLLOKUHZQAWUNF-IFZHGGHTSA-N 150474 US10238633, Example 148::US8987249, 148::US9713606, 148 Dipeptidyl peptidase 1 30.4 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150474&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430572 252824725 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289904 CN1Cc2cc(ccc2C1=O)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C26H25FN4O2/c1-31-12-16-6-13(4-5-18(16)26(31)33)14-2-3-15(22(27)8-14)7-17(11-28)29-25(32)24-21-10-23(30-24)20-9-19(20)21/h2-6,8,17,19-21,23-24,30H,7,9-10,12H2,1H3,(H,29,32)/t17-,19+,20-,21+,23-,24-/m0/s1 YVWVOYUBGOKFMC-VRTCABIXSA-N 150475 US10238633, Example 149::US8987249, 149::US9713606, 149 Dipeptidyl peptidase 1 38.7 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150475 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150475&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430573 252824726 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289905 CNS(=O)(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C24H25FN4O3S/c1-27-33(31,32)17-6-4-13(5-7-17)14-2-3-15(21(25)9-14)8-16(12-26)28-24(30)23-20-11-22(29-23)19-10-18(19)20/h2-7,9,16,18-20,22-23,27,29H,8,10-11H2,1H3,(H,28,30)/t16-,18+,19-,20+,22-,23-/m0/s1 UZSYZFPBBVJDMU-VUPWWPOFSA-N 150476 US10238633, Example 150::US8987249, 150::US9713606, 150 Dipeptidyl peptidase 1 38.6 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150476 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150476&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90440146 252824727 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289906 CCS(=O)(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C25H26FN3O3S/c1-2-33(31,32)18-7-5-14(6-8-18)15-3-4-16(22(26)10-15)9-17(13-27)28-25(30)24-21-12-23(29-24)20-11-19(20)21/h3-8,10,17,19-21,23-24,29H,2,9,11-12H2,1H3,(H,28,30)/t17-,19+,20-,21+,23-,24-/m0/s1 XTVUWKAUOSAVCH-VRTCABIXSA-N 150477 US10238633, Example 151::US8987249, 151::US9713606, 151 Dipeptidyl peptidase 1 36.9 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150477&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90440145 252824728 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289907 CS(=O)(=O)c1cc(ccc1F)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H23F2N3O3S/c1-32(30,31)21-11-14(5-7-19(21)24)13-2-3-15(20(25)10-13)8-18(12-26)28-23(29)22-16-4-6-17(9-16)27-22/h2-3,5,7,10-11,16-18,22,27H,4,6,8-9H2,1H3,(H,28,29)/t16-,17+,18-,22-/m0/s1 MQUCJSMVHXVYQA-SUWCGCSTSA-N 150478 US10238633, Example 152::US8987249, 152::US9713606, 152 Dipeptidyl peptidase 1 2.1 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150478 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150478&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430590 252824729 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289908 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cccc(c1)S(=O)(=O)C1CC1 InChI=1S/C25H26FN3O3S/c26-23-13-16(15-2-1-3-22(12-15)33(31,32)21-8-9-21)4-5-17(23)10-20(14-27)29-25(30)24-18-6-7-19(11-18)28-24/h1-5,12-13,18-21,24,28H,6-11H2,(H,29,30)/t18-,19+,20-,24-/m0/s1 OOGGADCCZJKURU-VKDGWMQASA-N 150479 US10238633, Example 153::US8987249, 153::US9713606, 153 Dipeptidyl peptidase 1 3.8 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150479&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430710 252824730 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289909 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCN(CC2CCCO2)CC1 InChI=1S/C25H34FN5O2/c26-23-14-21(31-9-7-30(8-10-31)16-22-2-1-11-33-22)6-4-17(23)12-20(15-27)29-25(32)24-18-3-5-19(13-18)28-24/h4,6,14,18-20,22,24,28H,1-3,5,7-13,16H2,(H,29,32)/t18-,19+,20-,22?,24-/m0/s1 NOJDRJVHLUWQDY-GTVKUMRUSA-N 150480 US10238633, Example 154::US8987249, 154 Dipeptidyl peptidase 1 13.5 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150480 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150480&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430763 252824731 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289910 CN1CCN(CC1)S(=O)(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C27H32FN5O3S/c1-32-10-12-33(13-11-32)37(35,36)24-8-5-18(6-9-24)19-2-3-20(25(28)16-19)14-23(17-29)31-27(34)26-21-4-7-22(15-21)30-26/h2-3,5-6,8-9,16,21-23,26,30H,4,7,10-15H2,1H3,(H,31,34)/t21-,22+,23-,26-/m0/s1 JTEJDGCXJPQUEE-LNEBKTTKSA-N 150481 US10238633, Example 155::US8987249, 155::US9713606, 155 Dipeptidyl peptidase 1 0.8 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150481 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150481&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430713 252824732 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289911 CC1(C)OC(=O)c2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C26H26FN3O3/c1-26(2)21-11-14(6-8-20(21)25(32)33-26)15-3-4-16(22(27)12-15)9-19(13-28)30-24(31)23-17-5-7-18(10-17)29-23/h3-4,6,8,11-12,17-19,23,29H,5,7,9-10H2,1-2H3,(H,30,31)/t17-,18+,19-,23-/m0/s1 JLXZFFFCLDPPDS-YWNPBTLJSA-N 150482 US10238633, Example 156::US8987249, 156::US9713606, 156 Dipeptidyl peptidase 1 0.6 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150482 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150482&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430711 252824733 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289912 NC(=O)c1cc(cs1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H21FN4O2S/c22-17-7-11(14-8-18(20(24)27)29-10-14)1-2-12(17)5-16(9-23)26-21(28)19-13-3-4-15(6-13)25-19/h1-2,7-8,10,13,15-16,19,25H,3-6H2,(H2,24,27)(H,26,28)/t13-,15+,16-,19-/m0/s1 PPGCNUWVAWUDDJ-YBKUAAOGSA-N 150483 US10238633, Example 157::US8987249, 157::US9713606, 157 Dipeptidyl peptidase 1 0.9 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150483&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430439 252824734 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289913 COCCN1C(=O)Cc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C27H29FN4O3/c1-35-9-8-32-24-13-17(3-5-19(24)14-25(32)33)16-2-4-18(23(28)12-16)10-22(15-29)31-27(34)26-20-6-7-21(11-20)30-26/h2-5,12-13,20-22,26,30H,6-11,14H2,1H3,(H,31,34)/t20-,21+,22-,26-/m0/s1 UCFPAQYLFQEDGE-MSZDEVHKSA-N 150484 US10238633, Example 158::US8987249, 158::US9713606, 158 Dipeptidyl peptidase 1 1.5 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150484&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430356 252824735 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289914 CS(=O)(=O)c1ccc(cc1C#N)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H23FN4O3S/c1-33(31,32)22-7-5-14(8-18(22)12-26)15-2-3-16(21(25)11-15)9-20(13-27)29-24(30)23-17-4-6-19(10-17)28-23/h2-3,5,7-8,11,17,19-20,23,28H,4,6,9-10H2,1H3,(H,29,30)/t17-,19+,20-,23-/m0/s1 ITRTUPJLHWDSML-USKVXJDGSA-N 150485 US10238633, Example 159::US8987249, 159::US9713606, 159 Dipeptidyl peptidase 1 1.6 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150485 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150485&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430392 252824736 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289915 Cc1nn(C)cc1-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H24FN5O/c1-12-18(11-27(2)26-12)13-3-4-14(19(22)9-13)7-17(10-23)25-21(28)20-15-5-6-16(8-15)24-20/h3-4,9,11,15-17,20,24H,5-8H2,1-2H3,(H,25,28)/t15-,16+,17-,20-/m0/s1 PJLDKVMJPLPBAC-CLWJZODNSA-N 150486 US10238633, Example 160::US8987249, 160::US9713606, 160 Dipeptidyl peptidase 1 1.7 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150486 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150486&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430385 252824737 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289916 CNC(=O)c1cc(cs1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H23FN4O2S/c1-25-21(28)19-9-15(11-30-19)12-2-3-13(18(23)8-12)6-17(10-24)27-22(29)20-14-4-5-16(7-14)26-20/h2-3,8-9,11,14,16-17,20,26H,4-7H2,1H3,(H,25,28)(H,27,29)/t14-,16+,17-,20-/m0/s1 XLNGTIPWUNYKLV-FORWCCJISA-N 150487 US10238633, Example 161::US8987249, 161::US9713606, 161 Dipeptidyl peptidase 1 1.9 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150487 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150487&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430393 252824738 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289917 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc(o1)C#N InChI=1S/C21H19FN4O2/c22-18-9-13(19-6-5-17(11-24)28-19)2-1-12(18)7-16(10-23)26-21(27)20-14-3-4-15(8-14)25-20/h1-2,5-6,9,14-16,20,25H,3-4,7-8H2,(H,26,27)/t14-,15+,16-,20-/m0/s1 MKOXMDMJBGUVAL-QOIOWGMHSA-N 150488 US10238633, Example 162::US8987249, 162::US9713606, 162 Dipeptidyl peptidase 1 2 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150488 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150488&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430754 252824739 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289918 Cn1cc(cn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C20H22FN5O/c1-26-11-15(10-23-26)12-2-3-13(18(21)8-12)6-17(9-22)25-20(27)19-14-4-5-16(7-14)24-19/h2-3,8,10-11,14,16-17,19,24H,4-7H2,1H3,(H,25,27)/t14-,16+,17-,19-/m0/s1 KPMQKTGWDITMBY-RUENVJTFSA-N 150489 US10238633, Example 163::US8987249, 163::US9713606, 163 Dipeptidyl peptidase 1 2.1 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150489 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150489&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430794 252824740 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289919 CCCNC(=O)c1cc(cs1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H27FN4O2S/c1-2-7-27-23(30)21-11-17(13-32-21)14-3-4-15(20(25)10-14)8-19(12-26)29-24(31)22-16-5-6-18(9-16)28-22/h3-4,10-11,13,16,18-19,22,28H,2,5-9H2,1H3,(H,27,30)(H,29,31)/t16-,18+,19-,22-/m0/s1 YDADTGZYWBWBFN-ZBPHCFQXSA-N 150490 US10238633, Example 164::US8987249, 164::US9713606, 164 Dipeptidyl peptidase 1 2.3 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150490 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150490&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430864 252824741 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289920 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1csc(c1)C(=O)N1CCCC1 InChI=1S/C25H27FN4O2S/c26-21-11-15(18-12-22(33-14-18)25(32)30-7-1-2-8-30)3-4-16(21)9-20(13-27)29-24(31)23-17-5-6-19(10-17)28-23/h3-4,11-12,14,17,19-20,23,28H,1-2,5-10H2,(H,29,31)/t17-,19+,20-,23-/m0/s1 LDCGUTCTCPBDJA-USKVXJDGSA-N 150491 US10238633, Example 165::US8987249, 165::US9713606, 165 Dipeptidyl peptidase 1 2.7 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150491 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150491&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430758 252824742 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289921 CC1(C)OC(=O)c2cc(ccc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C26H26FN3O3/c1-26(2)21-8-6-14(11-20(21)25(32)33-26)15-3-4-16(22(27)12-15)9-19(13-28)30-24(31)23-17-5-7-18(10-17)29-23/h3-4,6,8,11-12,17-19,23,29H,5,7,9-10H2,1-2H3,(H,30,31)/t17-,18+,19-,23-/m0/s1 OAJPZRYTQVCUSS-YWNPBTLJSA-N 150492 US10238633, Example 166::US8987249, 166::US9713606, 166 Dipeptidyl peptidase 1 3.3 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150492 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150492&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430865 252824743 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289922 NC(=O)c1ccc(o1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H21FN4O3/c22-16-9-12(17-5-6-18(29-17)20(24)27)2-1-11(16)7-15(10-23)26-21(28)19-13-3-4-14(8-13)25-19/h1-2,5-6,9,13-15,19,25H,3-4,7-8H2,(H2,24,27)(H,26,28)/t13-,14+,15-,19-/m0/s1 QWPJDKJCATZPMT-YGTYGHESSA-N 150493 US10238633, Example 167::US8987249, 167::US9713606, 167 Dipeptidyl peptidase 1 3.4 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150493 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150493&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430248 252824744 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289923 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnn2cccnc12 InChI=1S/C22H21FN6O/c23-19-10-13(18-12-26-29-7-1-6-25-21(18)29)2-3-14(19)8-17(11-24)28-22(30)20-15-4-5-16(9-15)27-20/h1-3,6-7,10,12,15-17,20,27H,4-5,8-9H2,(H,28,30)/t15-,16+,17-,20-/m0/s1 UAJICJMQOYRRAS-CLWJZODNSA-N 150494 US10238633, Example 168::US8987249, 168::US9713606, 168 Dipeptidyl peptidase 1 3.7 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150494 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150494&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430249 252824745 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289924 CN1Cc2cc(ccc2S1(=O)=O)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H25FN4O3S/c1-29-13-18-8-14(5-7-22(18)33(29,31)32)15-2-3-16(21(25)11-15)9-20(12-26)28-24(30)23-17-4-6-19(10-17)27-23/h2-3,5,7-8,11,17,19-20,23,27H,4,6,9-10,13H2,1H3,(H,28,30)/t17-,19+,20-,23-/m0/s1 LHDHATUHLZCALX-USKVXJDGSA-N 150495 US10238633, Example 169::US8987249, 169::US9713606, 169 Dipeptidyl peptidase 1 4.1 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150495&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430258 252824746 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289925 CN(C)C(=O)c1cc(cs1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H25FN4O2S/c1-28(2)23(30)20-10-16(12-31-20)13-3-4-14(19(24)9-13)7-18(11-25)27-22(29)21-15-5-6-17(8-15)26-21/h3-4,9-10,12,15,17-18,21,26H,5-8H2,1-2H3,(H,27,29)/t15-,17+,18-,21-/m0/s1 BMZNBIDFQPNVPA-DKXUYOFUSA-N 150496 US10238633, Example 170::US8987249, 170::US9713606, 170 Dipeptidyl peptidase 1 4.2 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150496&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430265 252824747 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289926 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnn(c1)-c1ccccc1 InChI=1S/C25H24FN5O/c26-23-12-16(19-14-28-31(15-19)22-4-2-1-3-5-22)6-7-17(23)10-21(13-27)30-25(32)24-18-8-9-20(11-18)29-24/h1-7,12,14-15,18,20-21,24,29H,8-11H2,(H,30,32)/t18-,20+,21-,24-/m0/s1 DMZSQOLHWTVSKK-UQWVPHONSA-N 150497 US10238633, Example 171::US8987249, 171::US9713606, 171 Dipeptidyl peptidase 1 5 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150497&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430257 252824748 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289927 CCOc1nc(cs1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H23FN4O2S/c1-2-28-21-26-18(11-29-21)13-4-3-12(17(22)9-13)7-16(10-23)25-20(27)19-14-5-6-15(8-14)24-19/h3-4,9,11,14-16,19,24H,2,5-8H2,1H3,(H,25,27)/t14-,15+,16-,19-/m0/s1 IWTOEPXDCLKGJZ-RCJHGTSTSA-N 150498 US10238633, Example 172::US8987249, 172::US9713606, 172 Dipeptidyl peptidase 1 5.2 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150498 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150498&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937196 252824749 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289928 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnc(s1)C1CC1 InChI=1S/C22H23FN4OS/c23-18-9-14(19-11-25-22(29-19)12-1-2-12)4-3-13(18)7-17(10-24)27-21(28)20-15-5-6-16(8-15)26-20/h3-4,9,11-12,15-17,20,26H,1-2,5-8H2,(H,27,28)/t15-,16+,17-,20-/m0/s1 UHFZBONSCYKOGY-CLWJZODNSA-N 150499 US10238633, Example 173::US8987249, 173::US9713606, 173 Dipeptidyl peptidase 1 5.5 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150499&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430637 252824750 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289929 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnc2cccnn12 InChI=1S/C22H21FN6O/c23-18-10-14(19-12-25-20-2-1-7-26-29(19)20)4-3-13(18)8-17(11-24)28-22(30)21-15-5-6-16(9-15)27-21/h1-4,7,10,12,15-17,21,27H,5-6,8-9H2,(H,28,30)/t15-,16+,17-,21-/m0/s1 CCYSIWWCGWSLDL-DLRJPAPCSA-N 150500 US10238633, Example 174::US8987249, 174::US9713606, 174 Dipeptidyl peptidase 1 5.6 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150500&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430822 252824751 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289930 COC(=O)c1ccc(o1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H22FN3O4/c1-29-22(28)19-7-6-18(30-19)13-3-2-12(17(23)10-13)8-16(11-24)26-21(27)20-14-4-5-15(9-14)25-20/h2-3,6-7,10,14-16,20,25H,4-5,8-9H2,1H3,(H,26,27)/t14-,15+,16-,20-/m0/s1 DOSFIFURJGVDGZ-QOIOWGMHSA-N 150501 US10238633, Example 175::US8987249, 175::US9713606, 175 Dipeptidyl peptidase 1 6.3 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150501&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937197 252824752 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289931 CS(=O)(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1F InChI=1S/C23H23F2N3O3S/c1-32(30,31)18-7-3-13(4-8-18)19-9-5-14(20(24)21(19)25)10-17(12-26)28-23(29)22-15-2-6-16(11-15)27-22/h3-5,7-9,15-17,22,27H,2,6,10-11H2,1H3,(H,28,29)/t15-,16+,17-,22-/m0/s1 HFCMZDPZCZIGCP-GEYWLOKFSA-N 150502 US10238633, Example 176::US8987249, 176::US9713606, 176 Dipeptidyl peptidase 1 6.6 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150502&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430823 252824753 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289932 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc(cc1)S(=O)(=O)N1CCCCC1 InChI=1S/C27H31FN4O3S/c28-25-16-19(18-7-10-24(11-8-18)36(34,35)32-12-2-1-3-13-32)4-5-20(25)14-23(17-29)31-27(33)26-21-6-9-22(15-21)30-26/h4-5,7-8,10-11,16,21-23,26,30H,1-3,6,9,12-15H2,(H,31,33)/t21-,22+,23-,26-/m0/s1 QDYXJVMXCAOXIV-LNEBKTTKSA-N 150503 US10238633, Example 177::US8987249, 177::US9713606, 177 Dipeptidyl peptidase 1 7.4 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150503 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150503&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430824 252824754 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289933 COCCN1CCN(CC1C)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H34FN5O2/c1-16-15-30(8-7-29(16)9-10-32-2)21-6-4-17(22(25)13-21)11-20(14-26)28-24(31)23-18-3-5-19(12-18)27-23/h4,6,13,16,18-20,23,27H,3,5,7-12,15H2,1-2H3,(H,28,31)/t16?,18-,19+,20-,23-/m0/s1 OEWFJFIVDPBLOL-XPNKYNLISA-N 150504 US10238633, Example 178::US8987249, 178::US9713606, 178 Dipeptidyl peptidase 1 7.4 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150504&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443245 252824755 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289934 CCOC(=O)c1ccc(s1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H24FN3O3S/c1-2-30-23(29)20-8-7-19(31-20)14-4-3-13(18(24)11-14)9-17(12-25)27-22(28)21-15-5-6-16(10-15)26-21/h3-4,7-8,11,15-17,21,26H,2,5-6,9-10H2,1H3,(H,27,28)/t15-,16+,17-,21-/m0/s1 UYZWDKFSNQPGHZ-DLRJPAPCSA-N 150505 US10238633, Example 179::US8987249, 179::US9713606, 179 Dipeptidyl peptidase 1 7.5 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150505 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150505&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90440149 252824756 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289935 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-n1cccn1 InChI=1S/C19H20FN5O/c20-17-10-16(25-7-1-6-22-25)5-3-12(17)8-15(11-21)24-19(26)18-13-2-4-14(9-13)23-18/h1,3,5-7,10,13-15,18,23H,2,4,8-9H2,(H,24,26)/t13-,14+,15-,18-/m0/s1 YFJMUZCPWDVHKP-KRXQYRFLSA-N 150506 US10238633, Example 180::US8987249, 180::US9713606, 180 Dipeptidyl peptidase 1 7.7 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150506 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150506&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430716 252824757 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289936 Fc1c(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)ccc(c1F)-c1ccc2CC(=O)Nc2c1 InChI=1S/C24H22F2N4O2/c25-21-14(7-17(11-27)29-24(32)23-15-3-5-16(8-15)28-23)4-6-18(22(21)26)12-1-2-13-10-20(31)30-19(13)9-12/h1-2,4,6,9,15-17,23,28H,3,5,7-8,10H2,(H,29,32)(H,30,31)/t15-,16+,17-,23-/m0/s1 GZBOPPMZTWXCEG-IPPNXFFKSA-N 150507 US10238633, Example 181::US8987249, 181::US9713606, 181 Dipeptidyl peptidase 1 8.6 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150507 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150507&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443264 252824758 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289937 COCCN1CCN(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H32FN5O2/c1-31-11-10-28-6-8-29(9-7-28)20-5-3-16(21(24)14-20)12-19(15-25)27-23(30)22-17-2-4-18(13-17)26-22/h3,5,14,17-19,22,26H,2,4,6-13H2,1H3,(H,27,30)/t17-,18+,19-,22-/m0/s1 SACZOVLAILIBSM-WEMPKCCASA-N 150508 US10238633, Example 182::US8987249, 182::US9713606, 182 Dipeptidyl peptidase 1 8.8 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150508 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150508&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443246 252824759 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289938 CS(=O)(=O)c1cc(ccc1C#N)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1F InChI=1S/C24H22F2N4O3S/c1-34(32,33)20-10-13(2-3-16(20)11-27)19-7-5-14(21(25)22(19)26)8-18(12-28)30-24(31)23-15-4-6-17(9-15)29-23/h2-3,5,7,10,15,17-18,23,29H,4,6,8-9H2,1H3,(H,30,31)/t15-,17+,18-,23-/m0/s1 BHOUHJMWXTTXMV-XITLKHQFSA-N 150509 US10238633, Example 183::US8987249, 183::US9713606, 183 Dipeptidyl peptidase 1 8.8 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150509 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150509&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430803 252824760 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289939 CCNC(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C25H27FN4O2/c1-2-28-24(31)16-5-3-15(4-6-16)17-7-8-18(22(26)13-17)11-21(14-27)30-25(32)23-19-9-10-20(12-19)29-23/h3-8,13,19-21,23,29H,2,9-12H2,1H3,(H,28,31)(H,30,32)/t19-,20+,21-,23-/m0/s1 QONINOVIALYSKY-KGSLCBSSSA-N 150510 US10238633, Example 184::US8987249, 184::US9713606, 184 Dipeptidyl peptidase 1 8.8 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150510 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150510&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430780 252824761 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289940 CN1CCN(CC1)C(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C28H32FN5O2/c1-33-10-12-34(13-11-33)28(36)19-4-2-18(3-5-19)20-6-7-21(25(29)16-20)14-24(17-30)32-27(35)26-22-8-9-23(15-22)31-26/h2-7,16,22-24,26,31H,8-15H2,1H3,(H,32,35)/t22-,23+,24-,26-/m0/s1 BCTCYNYSBOFOGS-UHCVVMIDSA-N 150511 US10238633, Example 185::US8987249, 185::US9713606, 185 Dipeptidyl peptidase 1 9 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150511 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150511&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443251 252824762 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289941 CNC(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H25FN4O2/c1-27-23(30)15-4-2-14(3-5-15)16-6-7-17(21(25)12-16)10-20(13-26)29-24(31)22-18-8-9-19(11-18)28-22/h2-7,12,18-20,22,28H,8-11H2,1H3,(H,27,30)(H,29,31)/t18-,19+,20-,22-/m0/s1 LNYQNVOBORIQSU-IIZPIQPGSA-N 150512 US10238633, Example 186::US8987249, 186::US9713606, 186 Dipeptidyl peptidase 1 9.6 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150512 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150512&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443253 252824763 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289942 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCN(CC1)C1CC1 InChI=1S/C23H30FN5O/c24-21-13-20(29-9-7-28(8-10-29)19-5-6-19)4-2-15(21)11-18(14-25)27-23(30)22-16-1-3-17(12-16)26-22/h2,4,13,16-19,22,26H,1,3,5-12H2,(H,27,30)/t16-,17+,18-,22-/m0/s1 KRGWGKDDVUPCTC-SUWCGCSTSA-N 150513 US10238633, Example 187::US8987249, 187::US9713606, 187 Dipeptidyl peptidase 1 9.8 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150513 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150513&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430775 252824764 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289943 C[C@H]1CN(C)CCN1c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H30FN5O/c1-14-13-27(2)7-8-28(14)19-6-4-15(20(23)11-19)9-18(12-24)26-22(29)21-16-3-5-17(10-16)25-21/h4,6,11,14,16-18,21,25H,3,5,7-10,13H2,1-2H3,(H,26,29)/t14-,16-,17+,18-,21-/m0/s1 PITCSQNCAUTIHO-ODKKXURNSA-N 150514 US10238633, Example 188::US8987249, 188::US9713606, 188 Dipeptidyl peptidase 1 9.8 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150514&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430776 252824765 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289944 Fc1cc(OCCN2CCNCC2)ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N InChI=1S/C22H30FN5O2/c23-20-13-19(30-10-9-28-7-5-25-6-8-28)4-2-15(20)11-18(14-24)27-22(29)21-16-1-3-17(12-16)26-21/h2,4,13,16-18,21,25-26H,1,3,5-12H2,(H,27,29)/t16-,17+,18-,21-/m0/s1 DYZTZKMZXIOJOY-NYUBLWNDSA-N 150515 US10238633, Example 189::US8987249, 189::US9713606, 189 Dipeptidyl peptidase 1 10.4 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150515&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430777 252824766 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289945 OCCN1CCN(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H30FN5O2/c23-20-13-19(28-7-5-27(6-8-28)9-10-29)4-2-15(20)11-18(14-24)26-22(30)21-16-1-3-17(12-16)25-21/h2,4,13,16-18,21,25,29H,1,3,5-12H2,(H,26,30)/t16-,17+,18-,21-/m0/s1 JYCKJIYGTBLGHE-NYUBLWNDSA-N 150516 US10238633, Example 190::US8987249, 190::US9713606, 190 Dipeptidyl peptidase 1 10.9 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150516 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150516&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430846 252824767 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289946 COCCN1C(C)CN(CC1C)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C25H36FN5O2/c1-16-14-30(15-17(2)31(16)8-9-33-3)22-7-5-18(23(26)12-22)10-21(13-27)29-25(32)24-19-4-6-20(11-19)28-24/h5,7,12,16-17,19-21,24,28H,4,6,8-11,14-15H2,1-3H3,(H,29,32)/t16?,17?,19-,20+,21-,24-/m0/s1 KNULSPGFBWAFEV-QAGFWZOLSA-N 150517 US10238633, Example 191::US8987249, 191::US9713606, 191 Dipeptidyl peptidase 1 11.2 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150517 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150517&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430872 252824768 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289879 CC(C)OCc1cn(nn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H27FN6O2/c1-13(2)31-12-18-11-29(28-27-18)19-6-4-14(20(23)9-19)7-17(10-24)26-22(30)21-15-3-5-16(8-15)25-21/h4,6,9,11,13,15-17,21,25H,3,5,7-8,12H2,1-2H3,(H,26,30)/t15-,16+,17-,21-/m0/s1 QPKNBTUQMSLXJI-DLRJPAPCSA-N 150450 US10238633, Example 124::US8987249, 124::US9713606, 124 Dipeptidyl peptidase 1 186.9 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150450 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150450&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430741 252824701 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289947 CC1CN(C)CCN1c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H30FN5O/c1-14-13-27(2)7-8-28(14)19-6-4-15(20(23)11-19)9-18(12-24)26-22(29)21-16-3-5-17(10-16)25-21/h4,6,11,14,16-18,21,25H,3,5,7-10,13H2,1-2H3,(H,26,29)/t14?,16-,17+,18-,21-/m0/s1 PITCSQNCAUTIHO-PGKCESFNSA-N 150518 US10238633, Example 192::US8987249, 192::US9713606, 192 Dipeptidyl peptidase 1 11.3 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150518 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150518&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430873 252824769 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289948 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCC(CC1)N1CCOCC1 InChI=1S/C25H34FN5O2/c26-23-15-22(30-7-5-21(6-8-30)31-9-11-33-12-10-31)4-2-17(23)13-20(16-27)29-25(32)24-18-1-3-19(14-18)28-24/h2,4,15,18-21,24,28H,1,3,5-14H2,(H,29,32)/t18-,19+,20-,24-/m0/s1 JABMZGKUYITGQO-VKDGWMQASA-N 150519 US10238633, Example 193::US8987249, 193::US9713606, 193 Dipeptidyl peptidase 1 12.3 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150519 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150519&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430847 252824770 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289949 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnc2cnccn12 InChI=1S/C22H21FN6O/c23-18-9-14(19-11-26-20-12-25-5-6-29(19)20)2-1-13(18)7-17(10-24)28-22(30)21-15-3-4-16(8-15)27-21/h1-2,5-6,9,11-12,15-17,21,27H,3-4,7-8H2,(H,28,30)/t15-,16+,17-,21-/m0/s1 DLTNLHDASBIQQA-DLRJPAPCSA-N 150520 US10238633, Example 194::US8987249, 194::US9713606, 194 Dipeptidyl peptidase 1 13.3 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150520 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150520&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430813 252824771 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289950 CC1(C)CCN(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H31FN4O/c1-23(2)7-9-28(10-8-23)19-6-4-15(20(24)13-19)11-18(14-25)27-22(29)21-16-3-5-17(12-16)26-21/h4,6,13,16-18,21,26H,3,5,7-12H2,1-2H3,(H,27,29)/t16-,17+,18-,21-/m0/s1 BXFGDWVBWBYTHB-NYUBLWNDSA-N 150521 US10238633, Example 195::US8987249, 195::US9713606, 195 Dipeptidyl peptidase 1 14.7 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150521&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443244 252824772 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289951 CC1CN(C(C)CN1C)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H32FN5O/c1-14-13-29(15(2)12-28(14)3)20-7-5-16(21(24)10-20)8-19(11-25)27-23(30)22-17-4-6-18(9-17)26-22/h5,7,10,14-15,17-19,22,26H,4,6,8-9,12-13H2,1-3H3,(H,27,30)/t14?,15?,17-,18+,19-,22-/m0/s1 HJMOTVPNQZUZFS-MHRVTNIKSA-N 150522 US10238633, Example 196::US8987249, 196::US9713606, 196 Dipeptidyl peptidase 1 15.1 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150522 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150522&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443160 252824773 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289952 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCCCC1 InChI=1S/C21H27FN4O/c22-19-12-18(26-8-2-1-3-9-26)7-5-14(19)10-17(13-23)25-21(27)20-15-4-6-16(11-15)24-20/h5,7,12,15-17,20,24H,1-4,6,8-11H2,(H,25,27)/t15-,16+,17-,20-/m0/s1 NAECJPAQRDJHFX-CLWJZODNSA-N 150523 US10238633, Example 197::US8987249, 197::US9713606, 197 Dipeptidyl peptidase 1 15.6 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150523 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150523&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430381 252824774 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289953 COC(=O)c1cc(C)c(s1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H24FN3O3S/c1-12-7-19(23(29)30-2)31-21(12)15-4-3-13(18(24)10-15)8-17(11-25)27-22(28)20-14-5-6-16(9-14)26-20/h3-4,7,10,14,16-17,20,26H,5-6,8-9H2,1-2H3,(H,27,28)/t14-,16+,17-,20-/m0/s1 TWRCTBLMEJQQQC-FORWCCJISA-N 150524 US10238633, Example 198::US8987249, 198::US9713606, 198 Dipeptidyl peptidase 1 15.8 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150524 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150524&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430382 252824775 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289954 CN1C(=O)C(C)(C)c2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C27H29FN4O2/c1-27(2)21-9-7-16(13-23(21)32(3)26(27)34)15-4-5-17(22(28)12-15)10-20(14-29)31-25(33)24-18-6-8-19(11-18)30-24/h4-5,7,9,12-13,18-20,24,30H,6,8,10-11H2,1-3H3,(H,31,33)/t18-,19+,20-,24-/m0/s1 BDKPRFCKGSLJAZ-VKDGWMQASA-N 150525 US10238633, Example 199::US8987249, 199::US9713606, 199 Dipeptidyl peptidase 1 16 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150525 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150525&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443273 252824776 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289955 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc(cc1)C(=O)NC1CCOCC1 InChI=1S/C28H31FN4O3/c29-25-15-19(17-1-3-18(4-2-17)27(34)32-22-9-11-36-12-10-22)5-6-20(25)13-24(16-30)33-28(35)26-21-7-8-23(14-21)31-26/h1-6,15,21-24,26,31H,7-14H2,(H,32,34)(H,33,35)/t21-,23+,24-,26-/m0/s1 YVIQKIOIKPSZTK-YUZJIJRXSA-N 150526 US10238633, Example 200::US8987249, 200::US9713606, 200 Dipeptidyl peptidase 1 16.5 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150526&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430342 252824777 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289956 CCN1CCC(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H31FN4O/c1-2-28-9-7-15(8-10-28)16-3-4-17(21(24)13-16)11-20(14-25)27-23(29)22-18-5-6-19(12-18)26-22/h3-4,13,15,18-20,22,26H,2,5-12H2,1H3,(H,27,29)/t18-,19+,20-,22-/m0/s1 KZEDFSYJDOOQDK-IIZPIQPGSA-N 150527 US10238633, Example 201::US8987249, 201::US9713606, 201 Dipeptidyl peptidase 1 20.1 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150527 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150527&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430343 252824778 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289957 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc(cc1)C(=O)N1CCOCC1 InChI=1S/C27H29FN4O3/c28-24-15-19(17-1-3-18(4-2-17)27(34)32-9-11-35-12-10-32)5-6-20(24)13-23(16-29)31-26(33)25-21-7-8-22(14-21)30-25/h1-6,15,21-23,25,30H,7-14H2,(H,31,33)/t21-,22+,23-,25-/m0/s1 KFKUTDHWQWJWKQ-AANQFLQQSA-N 150528 US10238633, Example 202::US8987249, 202::US9713606, 202 Dipeptidyl peptidase 1 22.9 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150528&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430344 252824779 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289958 O=C(NC(Cc1ccc2c(c1)[nH]c1ccccc21)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 150529 US10238633, Example 203::US8987249, 203::US9713606, 203 Dipeptidyl peptidase 1 23.3 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150529 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150529&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430597 252824780 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289959 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCNCC1 InChI=1S/C20H26FN5O/c21-18-11-17(26-7-5-23-6-8-26)4-2-13(18)9-16(12-22)25-20(27)19-14-1-3-15(10-14)24-19/h2,4,11,14-16,19,23-24H,1,3,5-10H2,(H,25,27)/t14-,15+,16-,19-/m0/s1 IMHSIFFWUGPDKM-RCJHGTSTSA-N 150530 BDBM150661::US10238633, Example 335::US8987249, 204::US9713606, 335 Dipeptidyl peptidase 1 24.5 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150530&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430619 252824781 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289960 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCOCC1 InChI=1S/C20H25FN4O2/c21-18-11-17(25-5-7-27-8-6-25)4-2-13(18)9-16(12-22)24-20(26)19-14-1-3-15(10-14)23-19/h2,4,11,14-16,19,23H,1,3,5-10H2,(H,24,26)/t14-,15+,16-,19-/m0/s1 ZYYSFTGHYITWSH-RCJHGTSTSA-N 150531 US10238633, Example 205::US8987249, 205::US9713606, 205 Dipeptidyl peptidase 1 25.9 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150531&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430744 252824782 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289961 Cn1c2ccccc2c2ccc(CC(NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)cc2c1=O InChI=1S/C24H24N4O2/c1-28-21-5-3-2-4-19(21)18-9-6-14(11-20(18)24(28)30)10-17(13-25)27-23(29)22-15-7-8-16(12-15)26-22/h2-6,9,11,15-17,22,26H,7-8,10,12H2,1H3,(H,27,29)/t15-,16+,17?,22-/m0/s1 WCVYQAOROBFJTQ-GDLIHOIBSA-N 150532 US10238633, Example 206::US8987249, 206::US9713606, 206 Dipeptidyl peptidase 1 26.3 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150532&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430402 252824783 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289962 Fc1ccc2c3ccc(CC(NC(=O)[C@H]4N[C@@H]5CC[C@H]4C5)C#N)cc3[nH]c(=O)c2c1 150533 US10238633, Example 207::US8987249, 207::US9713606, 207 Dipeptidyl peptidase 1 29.1 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150533&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937198 252824784 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289963 Cc1cn(C)c(n1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H24FN5O/c1-12-11-27(2)20(24-12)15-4-3-13(18(22)9-15)7-17(10-23)26-21(28)19-14-5-6-16(8-14)25-19/h3-4,9,11,14,16-17,19,25H,5-8H2,1-2H3,(H,26,28)/t14-,16+,17-,19-/m0/s1 GJGNZYPJMSRJNR-RUENVJTFSA-N 150534 US10238633, Example 208::US8987249, 208::US9713606, 208 Dipeptidyl peptidase 1 29.8 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150534&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430591 252824785 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289964 O=C(NC(Cc1ccc-2c(CCc3ccccc-23)c1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C24H25N3O/c25-14-20(27-24(28)23-18-8-9-19(13-18)26-23)12-15-5-10-22-17(11-15)7-6-16-3-1-2-4-21(16)22/h1-5,10-11,18-20,23,26H,6-9,12-13H2,(H,27,28)/t18-,19+,20?,23-/m0/s1 LBTNQDABYUUSSI-SRDOODBNSA-N 150535 US10238633, Example 209::US8987249, 209::US9713606, 209 Dipeptidyl peptidase 1 45.8 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150535&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430574 252824786 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289965 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc(cc1)C(=O)N1CCCCC1 InChI=1S/C28H31FN4O2/c29-25-16-20(18-4-6-19(7-5-18)28(35)33-12-2-1-3-13-33)8-9-21(25)14-24(17-30)32-27(34)26-22-10-11-23(15-22)31-26/h4-9,16,22-24,26,31H,1-3,10-15H2,(H,32,34)/t22-,23+,24-,26-/m0/s1 ZBKBAEOLQSSJOG-UHCVVMIDSA-N 150536 US10238633, Example 210::US8987249, 210::US9713606, 210 Dipeptidyl peptidase 1 49.4 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150536 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150536&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443249 252824787 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289966 CN(C)C(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C25H27FN4O2/c1-30(2)25(32)16-5-3-15(4-6-16)17-7-8-18(22(26)13-17)11-21(14-27)29-24(31)23-19-9-10-20(12-19)28-23/h3-8,13,19-21,23,28H,9-12H2,1-2H3,(H,29,31)/t19-,20+,21-,23-/m0/s1 KMGXMFJKQCFWPN-KGSLCBSSSA-N 150537 US10238633, Example 211::US8987249, 211::US9713606, 211 Dipeptidyl peptidase 1 61.1 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150537 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150537&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430595 252824788 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289967 O=C(NC(Cc1ccc2oc3ccccc3c2c1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C22H21N3O2/c23-12-16(25-22(26)21-14-6-7-15(11-14)24-21)9-13-5-8-20-18(10-13)17-3-1-2-4-19(17)27-20/h1-5,8,10,14-16,21,24H,6-7,9,11H2,(H,25,26)/t14-,15+,16?,21-/m0/s1 AMDWUZAQDYEPGE-DAGLJCOKSA-N 150538 US10238633, Example 212::US8987249, 212::US9713606, 212 Dipeptidyl peptidase 1 295.5 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150538 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150538&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430552 252824789 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289968 O=C(NC(Cc1ccc2[nH]c3ccccc3c2c1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 150539 US10238633, Example 213::US8987249, 213::US9713606, 213 Dipeptidyl peptidase 1 619 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150539 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150539&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430560 252824790 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289969 CS(=O)(=O)c1cc(ccc1C#N)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3CC[C@@H]2C3)C#N)c(F)c1 InChI=1S/C24H23FN4O3S/c1-33(31,32)22-11-15(3-5-18(22)12-26)14-2-4-16(21(25)10-14)8-20(13-27)29-24(30)23-17-6-7-19(9-17)28-23/h2-5,10-11,17,19-20,23,28H,6-9H2,1H3,(H,29,30)/t17-,19+,20+,23+/m1/s1 AUHJWFLPELHPMB-UYOCQKMUSA-N 150540 US10238633, Example 214::US8987249, 214::US9713606, 214 Dipeptidyl peptidase 1 814.8 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150540 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150540&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430534 252824791 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289970 Fc1ccc2c(c1)c(=O)[nH]c1cccc(CC(NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)c21 150541 US10238633, Example 215::US8987249, 215::US9713606, 215 Dipeptidyl peptidase 1 881.9 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150541 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150541&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937199 252824792 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289971 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc(cc1)S(=O)(=O)N1CCOCC1 InChI=1S/C26H29FN4O4S/c27-24-15-18(17-4-7-23(8-5-17)36(33,34)31-9-11-35-12-10-31)1-2-19(24)13-22(16-28)30-26(32)25-20-3-6-21(14-20)29-25/h1-2,4-5,7-8,15,20-22,25,29H,3,6,9-14H2,(H,30,32)/t20-,21+,22-,25-/m0/s1 JKOMQLYGPOVMIW-MTQWNXOMSA-N 150543 BDBM263789::US10238633, Example 217::US8987249, 217 Dipeptidyl peptidase 1 3.7 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150543 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150543&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443250 252824794 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289972 Fc1c(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)ccc(-c2cnn(CC3CCOCC3)c2)c1F InChI=1S/C25H29F2N5O2/c26-22-16(9-20(11-28)31-25(33)24-17-1-3-19(10-17)30-24)2-4-21(23(22)27)18-12-29-32(14-18)13-15-5-7-34-8-6-15/h2,4,12,14-15,17,19-20,24,30H,1,3,5-10,13H2,(H,31,33)/t17-,19+,20-,24-/m0/s1 YMORABQOPNMDEV-GHCZAOPSSA-N 150544 US10238633, Example 218::US8987249, 218::US9713606, 218 Dipeptidyl peptidase 1 18.9 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150544 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150544&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430698 252824795 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289973 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)C1CCN(Cc2ccccc2)CC1 InChI=1S/C28H33FN4O/c29-26-16-21(20-10-12-33(13-11-20)18-19-4-2-1-3-5-19)6-7-22(26)14-25(17-30)32-28(34)27-23-8-9-24(15-23)31-27/h1-7,16,20,23-25,27,31H,8-15,18H2,(H,32,34)/t23-,24+,25-,27-/m0/s1 SQFBEZWDNANXIK-SFIUMABJSA-N 150545 US10238633, Example 219::US8987249, 219::US9713606, 219 Dipeptidyl peptidase 1 37.4 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150545 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150545&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443270 252824796 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289974 O=C(N[C@@H](Cc1ccc2ccccc2c1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C20H21N3O/c21-12-18(23-20(24)19-16-7-8-17(11-16)22-19)10-13-5-6-14-3-1-2-4-15(14)9-13/h1-6,9,16-19,22H,7-8,10-11H2,(H,23,24)/t16-,17+,18-,19-/m0/s1 FNUIDHMDMWFOTD-RDGPPVDQSA-N 150546 US10238633, Example 220::US8987249, 220::US9713606, 220 Dipeptidyl peptidase 1 253 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150546 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150546&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430616 252824797 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289975 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnc2CCCn12 InChI=1S/C22H24FN5O/c23-18-10-14(19-12-25-20-2-1-7-28(19)20)4-3-13(18)8-17(11-24)27-22(29)21-15-5-6-16(9-15)26-21/h3-4,10,12,15-17,21,26H,1-2,5-9H2,(H,27,29)/t15-,16+,17-,21-/m0/s1 IJYAQVSCUDSUGF-DLRJPAPCSA-N 150547 US10238633, Example 221::US8987249, 221::US9713606, 221 Dipeptidyl peptidase 1 3.7 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150547 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150547&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430621 252824798 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289976 CS(=O)(=NC#N)c1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H24FN5O2S/c1-33(32,28-14-27)21-4-2-3-15(11-21)16-5-6-17(22(25)12-16)9-20(13-26)30-24(31)23-18-7-8-19(10-18)29-23/h2-6,11-12,18-20,23,29H,7-10H2,1H3,(H,30,31)/t18-,19+,20-,23-,33?/m0/s1 LPAPVHRQNZAJHB-PVEGDPQMSA-N 150548 US10238633, Example 222::US8987249, 222::US9713606, 222 Dipeptidyl peptidase 1 2.2 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150548 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150548&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443276 252824799 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289977 CN1CCC(=CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H27FN4O/c1-27-8-6-14(7-9-27)15-2-3-16(20(23)12-15)10-19(13-24)26-22(28)21-17-4-5-18(11-17)25-21/h2-3,6,12,17-19,21,25H,4-5,7-11H2,1H3,(H,26,28)/t17-,18+,19-,21-/m0/s1 YQARVKLTMMGHQQ-JTJHWIPRSA-N 150549 US10238633, Example 223::US8987249, 223::US9713606, 223 Dipeptidyl peptidase 1 5.9 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150549 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150549&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430440 252824800 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 289978 CN1CCN(CC1)S(=O)(=O)c1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C27H32FN5O3S/c1-32-9-11-33(12-10-32)37(35,36)24-4-2-3-18(15-24)19-5-6-20(25(28)16-19)13-23(17-29)31-27(34)26-21-7-8-22(14-21)30-26/h2-6,15-16,21-23,26,30H,7-14H2,1H3,(H,31,34)/t21-,22+,23-,26-/m0/s1 BCGCLCVNTALUEW-LNEBKTTKSA-N 150550 US10238633, Example 224::US8987249, 224::US9713606, 224 Dipeptidyl peptidase 1 1.2 25.00 C US Patent 10.7270/Q2KP80WG aid1800995 US8987249 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150550 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150550&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430441 252824801 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294731 Fc1cc(ccc1C#N)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C23H21FN4O/c24-21-11-16(5-6-18(21)12-25)15-3-1-14(2-4-15)9-20(13-26)28-23(29)22-17-7-8-19(10-17)27-22/h1-6,11,17,19-20,22,27H,7-10H2,(H,28,29)/t17-,19+,20-,22-/m0/s1 FTVPZFLARXLYEY-UFGBVDADSA-N 153484 US8999975, 1 Dipeptidyl peptidase 1 12 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153484&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89654450 253650604 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294732 O=C(N[C@@H](Cc1ccc(cc1)C1CCCCC1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C22H29N3O/c23-14-20(25-22(26)21-18-10-11-19(13-18)24-21)12-15-6-8-17(9-7-15)16-4-2-1-3-5-16/h6-9,16,18-21,24H,1-5,10-13H2,(H,25,26)/t18-,19+,20-,21-/m0/s1 KNZKXNBPYWSZCX-WOZUAGRISA-N 153485 US8999975, 2 Dipeptidyl peptidase 1 180 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153485 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153485&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89472131 253650605 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294733 O=C(N[C@@H](Cc1ccc(cc1)C1CCOCC1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C21H27N3O2/c22-13-19(24-21(25)20-17-5-6-18(12-17)23-20)11-14-1-3-15(4-2-14)16-7-9-26-10-8-16/h1-4,16-20,23H,5-12H2,(H,24,25)/t17-,18+,19-,20-/m0/s1 XXKQFGXUONDDCX-YRPNKDGESA-N 153486 US8999975, 3 Dipeptidyl peptidase 1 310 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153486 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153486&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89472126 253650606 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294734 O=C(N[C@@H](Cc1ccc(cc1)C1=CCCCC1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C22H27N3O/c23-14-20(25-22(26)21-18-10-11-19(13-18)24-21)12-15-6-8-17(9-7-15)16-4-2-1-3-5-16/h4,6-9,18-21,24H,1-3,5,10-13H2,(H,25,26)/t18-,19+,20-,21-/m0/s1 IFWFHVRWBPTTLC-WOZUAGRISA-N 153487 US8999975, 4 Dipeptidyl peptidase 1 15 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153487 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153487&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89472124 253650607 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294735 O=C(N[C@@H](Cc1ccc(cc1)C1=CCOCC1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C21H25N3O2/c22-13-19(24-21(25)20-17-5-6-18(12-17)23-20)11-14-1-3-15(4-2-14)16-7-9-26-10-8-16/h1-4,7,17-20,23H,5-6,8-12H2,(H,24,25)/t17-,18+,19-,20-/m0/s1 FMZVUUILEHTIHD-YRPNKDGESA-N 153488 US8999975, 5 Dipeptidyl peptidase 1 37 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153488 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153488&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89472123 253650608 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294736 CCS(=O)(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C24H27N3O3S/c1-2-31(29,30)22-11-8-18(9-12-22)17-5-3-16(4-6-17)13-21(15-25)27-24(28)23-19-7-10-20(14-19)26-23/h3-6,8-9,11-12,19-21,23,26H,2,7,10,13-14H2,1H3,(H,27,28)/t19-,20+,21-,23-/m0/s1 DHDOLROOYKWYTC-KGSLCBSSSA-N 153489 US8999975, 6 Dipeptidyl peptidase 1 15 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153489 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153489&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89472125 253650609 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294737 CN1C(=O)Cc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C25H26N4O2/c1-29-22-12-17(6-7-18(22)13-23(29)30)16-4-2-15(3-5-16)10-21(14-26)28-25(31)24-19-8-9-20(11-19)27-24/h2-7,12,19-21,24,27H,8-11,13H2,1H3,(H,28,31)/t19-,20+,21-,24-/m0/s1 OERBRFLUQGOVNO-XARGGIHNSA-N 153490 US8999975, 7 Dipeptidyl peptidase 1 6.5 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153490 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153490&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89654503 253650610 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294738 COCCCn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C27H30N4O4/c1-34-12-2-11-31-23-15-19(8-10-24(23)35-27(31)33)18-5-3-17(4-6-18)13-22(16-28)30-26(32)25-20-7-9-21(14-20)29-25/h3-6,8,10,15,20-22,25,29H,2,7,9,11-14H2,1H3,(H,30,32)/t20-,21+,22-,25-/m0/s1 VEVAOTLVVVUCFI-MTQWNXOMSA-N 153491 US8999975, 8 Dipeptidyl peptidase 1 3.2 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153491 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153491&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89669130 253650611 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294739 CN1CCC(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C22H30N4O/c1-26-10-8-17(9-11-26)16-4-2-15(3-5-16)12-20(14-23)25-22(27)21-18-6-7-19(13-18)24-21/h2-5,17-21,24H,6-13H2,1H3,(H,25,27)/t18-,19+,20-,21-/m0/s1 LZCFHMQOCHYBGF-WOZUAGRISA-N 153492 US8999975, 9 Dipeptidyl peptidase 1 120 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153492 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153492&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89669187 253650612 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294740 C=Cc1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C18H21N3O/c1-2-12-3-5-13(6-4-12)9-16(11-19)21-18(22)17-14-7-8-15(10-14)20-17/h2-6,14-17,20H,1,7-10H2,(H,21,22)/t14-,15+,16-,17-/m0/s1 QQYCPZFPINDKAC-YVSFHVDLSA-N 153493 US8999975, 10 Dipeptidyl peptidase 1 110 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153493 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153493&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89654391 253650613 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294741 CS(=O)(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C23H25N3O3S/c1-30(28,29)21-10-7-17(8-11-21)16-4-2-15(3-5-16)12-20(14-24)26-23(27)22-18-6-9-19(13-18)25-22/h2-5,7-8,10-11,18-20,22,25H,6,9,12-13H2,1H3,(H,26,27)/t18-,19+,20-,22-/m0/s1 HJAFQARZBGCFDL-IIZPIQPGSA-N 153494 US8999975, 11 Dipeptidyl peptidase 1 10 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153494 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153494&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89669063 253650614 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294742 CCc1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C18H23N3O/c1-2-12-3-5-13(6-4-12)9-16(11-19)21-18(22)17-14-7-8-15(10-14)20-17/h3-6,14-17,20H,2,7-10H2,1H3,(H,21,22)/t14-,15+,16-,17-/m0/s1 BVWYJDANJKDXFW-YVSFHVDLSA-N 153495 US8999975, 12 Dipeptidyl peptidase 1 310 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153495&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89654378 253650615 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294743 CS(=O)(=O)Oc1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C23H25N3O4S/c1-31(28,29)30-21-10-7-17(8-11-21)16-4-2-15(3-5-16)12-20(14-24)26-23(27)22-18-6-9-19(13-18)25-22/h2-5,7-8,10-11,18-20,22,25H,6,9,12-13H2,1H3,(H,26,27)/t18-,19+,20-,22-/m0/s1 MVNXRZSCNHQMHO-IIZPIQPGSA-N 153496 US8999975, 13 Dipeptidyl peptidase 1 11 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153496&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89669224 253650616 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294744 CC(=C)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C19H23N3O/c1-12(2)14-5-3-13(4-6-14)9-17(11-20)22-19(23)18-15-7-8-16(10-15)21-18/h3-6,15-18,21H,1,7-10H2,2H3,(H,22,23)/t15-,16+,17-,18-/m0/s1 UFJOJJBSNXHYPA-MHORFTMASA-N 153497 US8999975, 14 Dipeptidyl peptidase 1 120 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153497&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89669231 253650617 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294745 CN1CCN(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C21H29N5O/c1-25-8-10-26(11-9-25)19-6-2-15(3-7-19)12-18(14-22)24-21(27)20-16-4-5-17(13-16)23-20/h2-3,6-7,16-18,20,23H,4-5,8-13H2,1H3,(H,24,27)/t16-,17+,18-,20-/m0/s1 LWIHUGPPLJRCMY-DMUMMCEESA-N 153498 US8999975, 15 Dipeptidyl peptidase 1 38 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153498 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153498&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471744 253650618 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294746 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2C(=O)NCc2c1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C24H24N4O2/c25-12-20(28-24(30)22-17-5-7-19(11-17)27-22)9-14-1-3-15(4-2-14)16-6-8-21-18(10-16)13-26-23(21)29/h1-4,6,8,10,17,19-20,22,27H,5,7,9,11,13H2,(H,26,29)(H,28,30)/t17-,19+,20-,22-/m0/s1 JRQNHMIGVQABCX-UFGBVDADSA-N 153499 US8999975, 16 Dipeptidyl peptidase 1 8.6 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153499&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471742 253650619 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294747 Ic1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C16H18IN3O/c17-12-4-1-10(2-5-12)7-14(9-18)20-16(21)15-11-3-6-13(8-11)19-15/h1-2,4-5,11,13-15,19H,3,6-8H2,(H,20,21)/t11-,13+,14-,15-/m0/s1 RECLFOBPKIHVMF-ATGSNQNLSA-N 153500 US8999975, 17 Dipeptidyl peptidase 1 150 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153500&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471938 253650620 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294748 CC(C)=Cc1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C20H25N3O/c1-13(2)9-14-3-5-15(6-4-14)10-18(12-21)23-20(24)19-16-7-8-17(11-16)22-19/h3-6,9,16-19,22H,7-8,10-11H2,1-2H3,(H,23,24)/t16-,17+,18-,19-/m0/s1 SVKMKIPHFODJOZ-RDGPPVDQSA-N 153501 US8999975, 18 Dipeptidyl peptidase 1 64 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153501&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89669190 253650621 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294749 CC(C)Cc1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C20H27N3O/c1-13(2)9-14-3-5-15(6-4-14)10-18(12-21)23-20(24)19-16-7-8-17(11-16)22-19/h3-6,13,16-19,22H,7-11H2,1-2H3,(H,23,24)/t16-,17+,18-,19-/m0/s1 AAMPBZDKULBTSI-RDGPPVDQSA-N 153502 US8999975, 19 Dipeptidyl peptidase 1 300 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153502&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89472120 253650622 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294750 O=C(N[C@@H](Cc1ccc(cc1)N1CCN2CCCC2C1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C23H31N5O/c24-14-19(26-23(29)22-17-5-6-18(13-17)25-22)12-16-3-7-20(8-4-16)28-11-10-27-9-1-2-21(27)15-28/h3-4,7-8,17-19,21-22,25H,1-2,5-6,9-13,15H2,(H,26,29)/t17-,18+,19-,21?,22-/m0/s1 XPPWTJHJOODJQQ-GAHNEVOTSA-N 153503 US8999975, 20 Dipeptidyl peptidase 1 12 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153503 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153503&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89472119 253650623 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294751 O=C(N[C@@H](Cc1ccc(cc1)N1CCN(CC1)C(=O)C1CC1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C24H31N5O2/c25-15-20(27-23(30)22-18-5-6-19(14-18)26-22)13-16-1-7-21(8-2-16)28-9-11-29(12-10-28)24(31)17-3-4-17/h1-2,7-8,17-20,22,26H,3-6,9-14H2,(H,27,30)/t18-,19+,20-,22-/m0/s1 WFGUJMCVHUBYAT-IIZPIQPGSA-N 153504 US8999975, 21 Dipeptidyl peptidase 1 71 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153504&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89472122 253650624 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294752 CN1CCCN(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C22H31N5O/c1-26-9-2-10-27(12-11-26)20-7-3-16(4-8-20)13-19(15-23)25-22(28)21-17-5-6-18(14-17)24-21/h3-4,7-8,17-19,21,24H,2,5-6,9-14H2,1H3,(H,25,28)/t17-,18+,19-,21-/m0/s1 RBLSBDLKYKAYHU-JTJHWIPRSA-N 153505 US8999975, 22 Dipeptidyl peptidase 1 39 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153505 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153505&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89472121 253650625 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294753 CN1CCN(CC1=O)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C21H27N5O2/c1-25-8-9-26(13-19(25)27)18-6-2-14(3-7-18)10-17(12-22)24-21(28)20-15-4-5-16(11-15)23-20/h2-3,6-7,15-17,20,23H,4-5,8-11,13H2,1H3,(H,24,28)/t15-,16+,17-,20-/m0/s1 UAYIYMXSZZXZPT-CLWJZODNSA-N 153506 US8999975, 23 Dipeptidyl peptidase 1 78 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153506 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153506&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471990 253650626 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294754 CS(=O)(=O)N1CCN(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C21H29N5O3S/c1-30(28,29)26-10-8-25(9-11-26)19-6-2-15(3-7-19)12-18(14-22)24-21(27)20-16-4-5-17(13-16)23-20/h2-3,6-7,16-18,20,23H,4-5,8-13H2,1H3,(H,24,27)/t16-,17+,18-,20-/m0/s1 ZVBYWWKTQZUFTP-DMUMMCEESA-N 153507 US8999975, 24 Dipeptidyl peptidase 1 97 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153507 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153507&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471995 253650627 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294755 O=C(N[C@@H](Cc1ccc(cc1)N1CCc2sccc2C1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C23H26N4OS/c24-13-19(26-23(28)22-16-3-4-18(12-16)25-22)11-15-1-5-20(6-2-15)27-9-7-21-17(14-27)8-10-29-21/h1-2,5-6,8,10,16,18-19,22,25H,3-4,7,9,11-12,14H2,(H,26,28)/t16-,18+,19-,22-/m0/s1 PHLGTDRJQFDDBX-ZBPHCFQXSA-N 153508 US8999975, 25 Dipeptidyl peptidase 1 29 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153508 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153508&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471991 253650628 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294756 O=C(N[C@@H](Cc1ccc(cc1)N1CCN2C(CCC2=O)C1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C23H29N5O2/c24-13-18(26-23(30)22-16-3-4-17(12-16)25-22)11-15-1-5-19(6-2-15)27-9-10-28-20(14-27)7-8-21(28)29/h1-2,5-6,16-18,20,22,25H,3-4,7-12,14H2,(H,26,30)/t16-,17+,18-,20?,22-/m0/s1 WUHKLQRFFJWQAC-AEJWZEPGSA-N 153509 US8999975, 26 Dipeptidyl peptidase 1 63 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153509 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153509&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471992 253650629 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294757 CN(C)C(=O)N1CCN(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C23H32N6O2/c1-27(2)23(31)29-11-9-28(10-12-29)20-7-3-16(4-8-20)13-19(15-24)26-22(30)21-17-5-6-18(14-17)25-21/h3-4,7-8,17-19,21,25H,5-6,9-14H2,1-2H3,(H,26,30)/t17-,18+,19-,21-/m0/s1 FXTYSGPGXVFGQR-JTJHWIPRSA-N 153510 US8999975, 27 Dipeptidyl peptidase 1 150 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153510 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153510&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471994 253650630 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294758 COCc1cn(nn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C20H24N6O2/c1-28-12-17-11-26(25-24-17)18-6-2-13(3-7-18)8-16(10-21)23-20(27)19-14-4-5-15(9-14)22-19/h2-3,6-7,11,14-16,19,22H,4-5,8-9,12H2,1H3,(H,23,27)/t14-,15+,16-,19-/m0/s1 WPAZZBLZRYDKDW-RCJHGTSTSA-N 153511 US8999975, 28 Dipeptidyl peptidase 1 64 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153511 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153511&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471993 253650631 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294759 COc1ccc(cc1)-c1cn(nn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C25H26N6O2/c1-33-22-10-5-17(6-11-22)23-15-31(30-29-23)21-8-2-16(3-9-21)12-20(14-26)28-25(32)24-18-4-7-19(13-18)27-24/h2-3,5-6,8-11,15,18-20,24,27H,4,7,12-13H2,1H3,(H,28,32)/t18-,19+,20-,24-/m0/s1 QWIFOJPZWBHDDP-VKDGWMQASA-N 153512 US8999975, 29 Dipeptidyl peptidase 1 55 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153512 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153512&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471996 253650632 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294760 O=C(N[C@@H](Cc1ccc(cc1)C1CCN(Cc2ccccc2)CC1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C28H34N4O/c29-18-26(31-28(33)27-24-10-11-25(17-24)30-27)16-20-6-8-22(9-7-20)23-12-14-32(15-13-23)19-21-4-2-1-3-5-21/h1-9,23-27,30H,10-17,19H2,(H,31,33)/t24-,25+,26-,27-/m0/s1 UCOIEYCGYUQFPP-XUJYPJAKSA-N 153513 US8999975, 30 Dipeptidyl peptidase 1 200 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153513 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153513&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89472029 253650633 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294761 COc1cccc(c1)-c1cn(nn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C25H26N6O2/c1-33-22-4-2-3-17(13-22)23-15-31(30-29-23)21-9-5-16(6-10-21)11-20(14-26)28-25(32)24-18-7-8-19(12-18)27-24/h2-6,9-10,13,15,18-20,24,27H,7-8,11-12H2,1H3,(H,28,32)/t18-,19+,20-,24-/m0/s1 MDKKPHBVQBYJSJ-VKDGWMQASA-N 153514 US8999975, 31 Dipeptidyl peptidase 1 65 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153514&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89472031 253650634 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294762 CC(C)(O)c1cn(nn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C21H26N6O2/c1-21(2,29)18-12-27(26-25-18)17-7-3-13(4-8-17)9-16(11-22)24-20(28)19-14-5-6-15(10-14)23-19/h3-4,7-8,12,14-16,19,23,29H,5-6,9-10H2,1-2H3,(H,24,28)/t14-,15+,16-,19-/m0/s1 DWGLWYAEIFOQPA-RCJHGTSTSA-N 153515 US8999975, 32 Dipeptidyl peptidase 1 37 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153515&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91970496 253650635 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294763 COc1ccccc1-c1cn(nn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C25H26N6O2/c1-33-23-5-3-2-4-21(23)22-15-31(30-29-22)20-10-6-16(7-11-20)12-19(14-26)28-25(32)24-17-8-9-18(13-17)27-24/h2-7,10-11,15,17-19,24,27H,8-9,12-13H2,1H3,(H,28,32)/t17-,18+,19-,24-/m0/s1 CXUIGLZYZSJKCE-YDLHNXBPSA-N 153516 US8999975, 33 Dipeptidyl peptidase 1 150 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153516 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153516&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89472033 253650636 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294764 CC(C)S(=O)(=O)N1CCC(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C24H34N4O3S/c1-16(2)32(30,31)28-11-9-19(10-12-28)18-5-3-17(4-6-18)13-22(15-25)27-24(29)23-20-7-8-21(14-20)26-23/h3-6,16,19-23,26H,7-14H2,1-2H3,(H,27,29)/t20-,21+,22-,23-/m0/s1 ZKMCOPRLEDJKIQ-BJESRGMDSA-N 153517 US8999975, 34 Dipeptidyl peptidase 1 119 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153517 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153517&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471951 253650637 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294765 CCS(=O)(=O)N1CCC(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C23H32N4O3S/c1-2-31(29,30)27-11-9-18(10-12-27)17-5-3-16(4-6-17)13-21(15-24)26-23(28)22-19-7-8-20(14-19)25-22/h3-6,18-22,25H,2,7-14H2,1H3,(H,26,28)/t19-,20+,21-,22-/m0/s1 YDEOJJCURXXCIU-LRSLUSHPSA-N 153518 US8999975, 35 Dipeptidyl peptidase 1 121 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153518 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153518&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471949 253650638 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294766 CS(=O)(=O)N1CCC(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C22H30N4O3S/c1-30(28,29)26-10-8-17(9-11-26)16-4-2-15(3-5-16)12-20(14-23)25-22(27)21-18-6-7-19(13-18)24-21/h2-5,17-21,24H,6-13H2,1H3,(H,25,27)/t18-,19+,20-,21-/m0/s1 FYUNYGAIIUJKMJ-WOZUAGRISA-N 153519 US8999975, 36 Dipeptidyl peptidase 1 106 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153519 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153519&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471950 253650639 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294767 CC(C)NC(=O)N1CCC(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C25H35N5O2/c1-16(2)27-25(32)30-11-9-19(10-12-30)18-5-3-17(4-6-18)13-22(15-26)29-24(31)23-20-7-8-21(14-20)28-23/h3-6,16,19-23,28H,7-14H2,1-2H3,(H,27,32)(H,29,31)/t20-,21+,22-,23-/m0/s1 ZIKPNLITXLPCGH-BJESRGMDSA-N 153520 US8999975, 37 Dipeptidyl peptidase 1 259 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153520 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153520&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471948 253650640 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294768 CC(C)C(=O)N1CCC(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C25H34N4O2/c1-16(2)25(31)29-11-9-19(10-12-29)18-5-3-17(4-6-18)13-22(15-26)28-24(30)23-20-7-8-21(14-20)27-23/h3-6,16,19-23,27H,7-14H2,1-2H3,(H,28,30)/t20-,21+,22-,23-/m0/s1 FXNIJFVWKVVABF-BJESRGMDSA-N 153521 US8999975, 38 Dipeptidyl peptidase 1 268 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153521&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89472130 253650641 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294769 O=C(N[C@@H](Cc1ccc(cc1)-n1cc(nn1)C1CC1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C21H24N6O/c22-11-17(24-21(28)20-15-5-6-16(10-15)23-20)9-13-1-7-18(8-2-13)27-12-19(25-26-27)14-3-4-14/h1-2,7-8,12,14-17,20,23H,3-6,9-10H2,(H,24,28)/t15-,16+,17-,20-/m0/s1 QXOZCMABNLDLLF-CLWJZODNSA-N 153522 US8999975, 39 Dipeptidyl peptidase 1 37 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153522 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153522&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89472128 253650642 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294770 CN(C)S(=O)(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C24H28N4O3S/c1-28(2)32(30,31)22-11-8-18(9-12-22)17-5-3-16(4-6-17)13-21(15-25)27-24(29)23-19-7-10-20(14-19)26-23/h3-6,8-9,11-12,19-21,23,26H,7,10,13-14H2,1-2H3,(H,27,29)/t19-,20+,21-,23-/m0/s1 LPNYTJBFWVIIPA-KGSLCBSSSA-N 153523 US8999975, 40 Dipeptidyl peptidase 1 19 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153523 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153523&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89472129 253650643 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294771 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(nc1)C#N)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C22H21N5O/c23-11-19-8-6-17(13-25-19)15-3-1-14(2-4-15)9-20(12-24)27-22(28)21-16-5-7-18(10-16)26-21/h1-4,6,8,13,16,18,20-21,26H,5,7,9-10H2,(H,27,28)/t16-,18+,20-,21-/m0/s1 FYMZTSHDDDBPDC-OFCAXSSNSA-N 153524 US8999975, 41 Dipeptidyl peptidase 1 23 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153524 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153524&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89472132 253650644 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294772 CNS(=O)(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C23H26N4O3S/c1-25-31(29,30)21-10-7-17(8-11-21)16-4-2-15(3-5-16)12-20(14-24)27-23(28)22-18-6-9-19(13-18)26-22/h2-5,7-8,10-11,18-20,22,25-26H,6,9,12-13H2,1H3,(H,27,28)/t18-,19+,20-,22-/m0/s1 GKBALLNWHJEGEF-IIZPIQPGSA-N 153525 US8999975, 42 Dipeptidyl peptidase 1 17 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153525 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153525&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471956 253650645 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294773 CCC(=O)N1CCC(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C24H32N4O2/c1-2-22(29)28-11-9-18(10-12-28)17-5-3-16(4-6-17)13-21(15-25)27-24(30)23-19-7-8-20(14-19)26-23/h3-6,18-21,23,26H,2,7-14H2,1H3,(H,27,30)/t19-,20+,21-,23-/m0/s1 HPCITASMIXDLAC-KGSLCBSSSA-N 153526 US8999975, 43 Dipeptidyl peptidase 1 401 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153526&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471957 253650646 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294774 CC(=O)N1CCC(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C23H30N4O2/c1-15(28)27-10-8-18(9-11-27)17-4-2-16(3-5-17)12-21(14-24)26-23(29)22-19-6-7-20(13-19)25-22/h2-5,18-22,25H,6-13H2,1H3,(H,26,29)/t19-,20+,21-,22-/m0/s1 PNWUPHYYAAFNNZ-LRSLUSHPSA-N 153527 US8999975, 44 Dipeptidyl peptidase 1 253 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153527 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153527&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471958 253650647 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294775 FC(F)CN1CCC(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C23H30F2N4O/c24-21(25)14-29-9-7-17(8-10-29)16-3-1-15(2-4-16)11-20(13-26)28-23(30)22-18-5-6-19(12-18)27-22/h1-4,17-22,27H,5-12,14H2,(H,28,30)/t18-,19+,20-,22-/m0/s1 FNTUUWOMRXZAPT-IIZPIQPGSA-N 153528 US8999975, 45 Dipeptidyl peptidase 1 160 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153528&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471962 253650648 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294776 CCNC(=O)N1CCC(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C24H33N5O2/c1-2-26-24(31)29-11-9-18(10-12-29)17-5-3-16(4-6-17)13-21(15-25)28-23(30)22-19-7-8-20(14-19)27-22/h3-6,18-22,27H,2,7-14H2,1H3,(H,26,31)(H,28,30)/t19-,20+,21-,22-/m0/s1 QTUFDSBBBRMUME-LRSLUSHPSA-N 153529 US8999975, 46 Dipeptidyl peptidase 1 184 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153529 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153529&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471960 253650649 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294777 CCCC(=O)N1CCC(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C25H34N4O2/c1-2-3-23(30)29-12-10-19(11-13-29)18-6-4-17(5-7-18)14-22(16-26)28-25(31)24-20-8-9-21(15-20)27-24/h4-7,19-22,24,27H,2-3,8-15H2,1H3,(H,28,31)/t20-,21+,22-,24-/m0/s1 VEAHBRWVSWGHHF-KHUIQGCPSA-N 153530 US8999975, 47 Dipeptidyl peptidase 1 281 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153530&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471959 253650650 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294778 F[C@H]1C[C@@H]2C[C@H]1[C@H](N2)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(C#N)c(F)c1)C#N InChI=1S/C23H20F2N4O/c24-20-8-15(5-6-16(20)11-26)14-3-1-13(2-4-14)7-18(12-27)29-23(30)22-19-9-17(28-22)10-21(19)25/h1-6,8,17-19,21-22,28H,7,9-10H2,(H,29,30)/t17-,18-,19+,21-,22-/m0/s1 ZGZZWWAKSRRBQT-GVMRPCBKSA-N 153531 US8999975, 48 Dipeptidyl peptidase 1 66 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153531&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471963 253650651 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294779 F[C@@H]1C[C@@H]2C[C@H]1[C@H](N2)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(C#N)c(F)c1)C#N InChI=1S/C23H20F2N4O/c24-20-8-15(5-6-16(20)11-26)14-3-1-13(2-4-14)7-18(12-27)29-23(30)22-19-9-17(28-22)10-21(19)25/h1-6,8,17-19,21-22,28H,7,9-10H2,(H,29,30)/t17-,18-,19+,21+,22-/m0/s1 ZGZZWWAKSRRBQT-XUJOWKJQSA-N 153532 US8999975, 49 Dipeptidyl peptidase 1 410 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153532&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471961 253650652 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294780 O[C@H]1C[C@H]2C[C@@H]1N[C@@H]2C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(C#N)c(F)c1)C#N InChI=1S/C23H21FN4O2/c24-19-8-15(5-6-16(19)11-25)14-3-1-13(2-4-14)7-18(12-26)27-23(30)22-17-9-20(28-22)21(29)10-17/h1-6,8,17-18,20-22,28-29H,7,9-10H2,(H,27,30)/t17-,18+,20+,21+,22+/m1/s1 ZMJPMXXVIHXCKJ-NQOGSSOHSA-N 153533 BDBM153612::US8999975, 50 Dipeptidyl peptidase 1 13 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153533&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471968 253650653 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294781 O=C(N[C@@H](Cc1ccc(cc1)-n1cc(nn1)-c1cccnc1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C23H23N7O/c24-12-19(27-23(31)22-16-5-6-18(11-16)26-22)10-15-3-7-20(8-4-15)30-14-21(28-29-30)17-2-1-9-25-13-17/h1-4,7-9,13-14,16,18-19,22,26H,5-6,10-11H2,(H,27,31)/t16-,18+,19-,22-/m0/s1 HPQYFHCGKLYUTN-ZBPHCFQXSA-N 153534 US8999975, 51 Dipeptidyl peptidase 1 47 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153534&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471965 253650654 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294782 COc1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C23H25N3O2/c1-28-21-10-7-17(8-11-21)16-4-2-15(3-5-16)12-20(14-24)26-23(27)22-18-6-9-19(13-18)25-22/h2-5,7-8,10-11,18-20,22,25H,6,9,12-13H2,1H3,(H,26,27)/t18-,19+,20-,22-/m0/s1 HSHALVUMIUROOL-IIZPIQPGSA-N 153535 US8999975, 52 Dipeptidyl peptidase 1 25 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153535&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471972 253650655 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294783 O=C(N[C@@H](Cc1ccc(cc1)-c1cccc(c1)C#N)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C23H22N4O/c24-13-16-2-1-3-18(10-16)17-6-4-15(5-7-17)11-21(14-25)27-23(28)22-19-8-9-20(12-19)26-22/h1-7,10,19-22,26H,8-9,11-12H2,(H,27,28)/t19-,20+,21-,22-/m0/s1 JHBSNJIBGHGWPR-LRSLUSHPSA-N 153536 US8999975, 53 Dipeptidyl peptidase 1 17 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153536 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153536&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471966 253650656 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294784 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2OCOc2c1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C23H23N3O3/c24-12-19(26-23(27)22-17-5-7-18(10-17)25-22)9-14-1-3-15(4-2-14)16-6-8-20-21(11-16)29-13-28-20/h1-4,6,8,11,17-19,22,25H,5,7,9-10,13H2,(H,26,27)/t17-,18+,19-,22-/m0/s1 FUOHSPGGWQTDAF-WEMPKCCASA-N 153537 US8999975, 54 Dipeptidyl peptidase 1 17 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153537 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153537&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471970 253650657 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294785 CC(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C24H25N3O2/c1-15(28)17-6-8-19(9-7-17)18-4-2-16(3-5-18)12-22(14-25)27-24(29)23-20-10-11-21(13-20)26-23/h2-9,20-23,26H,10-13H2,1H3,(H,27,29)/t20-,21+,22-,23-/m0/s1 JPRBAWSCVHJEHX-BJESRGMDSA-N 153538 US8999975, 55 Dipeptidyl peptidase 1 9 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153538 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153538&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471973 253650658 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294786 COc1ccc(cn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C22H24N4O2/c1-28-20-9-7-17(13-24-20)15-4-2-14(3-5-15)10-19(12-23)26-22(27)21-16-6-8-18(11-16)25-21/h2-5,7,9,13,16,18-19,21,25H,6,8,10-11H2,1H3,(H,26,27)/t16-,18+,19-,21-/m0/s1 VOLANGYDMJTHPF-KRQVXIAISA-N 153539 US8999975, 56 Dipeptidyl peptidase 1 26 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153539 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153539&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471803 253650659 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294787 CS(=O)(=O)c1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C23H25N3O3S/c1-30(28,29)21-4-2-3-17(13-21)16-7-5-15(6-8-16)11-20(14-24)26-23(27)22-18-9-10-19(12-18)25-22/h2-8,13,18-20,22,25H,9-12H2,1H3,(H,26,27)/t18-,19+,20-,22-/m0/s1 WPBQFLFJUYNOOT-IIZPIQPGSA-N 153540 US8999975, 57 Dipeptidyl peptidase 1 16 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153540 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153540&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471799 253650660 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294788 COc1ncc(cn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C21H23N5O2/c1-28-21-23-11-16(12-24-21)14-4-2-13(3-5-14)8-18(10-22)26-20(27)19-15-6-7-17(9-15)25-19/h2-5,11-12,15,17-19,25H,6-9H2,1H3,(H,26,27)/t15-,17+,18-,19-/m0/s1 PYCQVDFSUIAJGB-NQYYFHDYSA-N 153541 US8999975, 58 Dipeptidyl peptidase 1 112 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153541 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153541&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471800 253650661 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294789 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2OCCc2c1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C24H25N3O2/c25-14-21(27-24(28)23-19-5-7-20(13-19)26-23)11-15-1-3-16(4-2-15)17-6-8-22-18(12-17)9-10-29-22/h1-4,6,8,12,19-21,23,26H,5,7,9-11,13H2,(H,27,28)/t19-,20+,21-,23-/m0/s1 AOXUQLAFCMEZBU-KGSLCBSSSA-N 153542 US8999975, 59 Dipeptidyl peptidase 1 12 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153542&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471801 253650662 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294790 COc1cc(ccn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C22H24N4O2/c1-28-20-12-16(8-9-24-20)15-4-2-14(3-5-15)10-19(13-23)26-22(27)21-17-6-7-18(11-17)25-21/h2-5,8-9,12,17-19,21,25H,6-7,10-11H2,1H3,(H,26,27)/t17-,18+,19-,21-/m0/s1 YATRVDXSAAOLAY-JTJHWIPRSA-N 153543 US8999975, 60 Dipeptidyl peptidase 1 31 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153543 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153543&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471798 253650663 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294791 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2cc[nH]c2c1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 153544 US8999975, 61 Dipeptidyl peptidase 1 25 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153544 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153544&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471804 253650664 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294792 COc1ccc(cc1OC)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C24H27N3O3/c1-29-21-10-8-17(13-22(21)30-2)16-5-3-15(4-6-16)11-20(14-25)27-24(28)23-18-7-9-19(12-18)26-23/h3-6,8,10,13,18-20,23,26H,7,9,11-12H2,1-2H3,(H,27,28)/t18-,19+,20-,23-/m0/s1 QSGXYOLJUABHIJ-SRYPRDQNSA-N 153545 US8999975, 62 Dipeptidyl peptidase 1 18 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153545 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153545&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471736 253650665 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294793 Clc1ccc(cc1C#N)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C23H21ClN4O/c24-21-8-6-16(10-18(21)12-25)15-3-1-14(2-4-15)9-20(13-26)28-23(29)22-17-5-7-19(11-17)27-22/h1-4,6,8,10,17,19-20,22,27H,5,7,9,11H2,(H,28,29)/t17-,19+,20-,22-/m0/s1 NWBJEQNIZUDDRX-UFGBVDADSA-N 153546 US8999975, 63 Dipeptidyl peptidase 1 8 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153546 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153546&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471743 253650666 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294794 Fc1cc(cc(F)c1F)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C22H20F3N3O/c23-18-9-15(10-19(24)20(18)25)13-3-1-12(2-4-13)7-17(11-26)28-22(29)21-14-5-6-16(8-14)27-21/h1-4,9-10,14,16-17,21,27H,5-8H2,(H,28,29)/t14-,16+,17-,21-/m0/s1 ATZDYNFTKVPVEL-CCFTVXDOSA-N 153547 US8999975, 64 Dipeptidyl peptidase 1 6 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153547 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153547&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471734 253650667 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294795 Cn1nccc1-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C20H23N5O/c1-25-18(8-9-22-25)14-4-2-13(3-5-14)10-17(12-21)24-20(26)19-15-6-7-16(11-15)23-19/h2-5,8-9,15-17,19,23H,6-7,10-11H2,1H3,(H,24,26)/t15-,16+,17-,19-/m0/s1 QRYREAKHSGSKLT-ZMMAXQRCSA-N 153548 US8999975, 65 Dipeptidyl peptidase 1 132 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153548 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153548&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471738 253650668 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294796 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2cn[nH]c2c1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 153549 US8999975, 66 Dipeptidyl peptidase 1 11 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153549 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153549&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471739 253650669 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294797 Cn1ncc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C24H25N5O/c1-29-22-12-17(6-7-19(22)14-26-29)16-4-2-15(3-5-16)10-21(13-25)28-24(30)23-18-8-9-20(11-18)27-23/h2-7,12,14,18,20-21,23,27H,8-11H2,1H3,(H,28,30)/t18-,20+,21-,23-/m0/s1 YEISSBXQUOEZAU-SQMWVJLWSA-N 153550 US8999975, 67 Dipeptidyl peptidase 1 7 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153550 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153550&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471740 253650670 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294798 Cn1cnc2cc(cnc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C23H24N6O/c1-29-13-26-20-10-17(12-25-22(20)29)15-4-2-14(3-5-15)8-19(11-24)28-23(30)21-16-6-7-18(9-16)27-21/h2-5,10,12-13,16,18-19,21,27H,6-9H2,1H3,(H,28,30)/t16-,18+,19-,21-/m0/s1 LAZYUPCKLHGWJI-KRQVXIAISA-N 153551 US8999975, 68 Dipeptidyl peptidase 1 277 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153551 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153551&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89667245 253650671 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294799 Cn1ncc2cc(ccc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C24H25N5O/c1-29-22-9-7-17(11-19(22)14-26-29)16-4-2-15(3-5-16)10-21(13-25)28-24(30)23-18-6-8-20(12-18)27-23/h2-5,7,9,11,14,18,20-21,23,27H,6,8,10,12H2,1H3,(H,28,30)/t18-,20+,21-,23-/m0/s1 UZNKDGSVMZWCBV-SQMWVJLWSA-N 153552 US8999975, 69 Dipeptidyl peptidase 1 23 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153552&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89472050 253650672 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294800 Cc1nc2cc(ccc2o1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C24H24N4O2/c1-14-26-21-12-17(7-9-22(21)30-14)16-4-2-15(3-5-16)10-20(13-25)28-24(29)23-18-6-8-19(11-18)27-23/h2-5,7,9,12,18-20,23,27H,6,8,10-11H2,1H3,(H,28,29)/t18-,19+,20-,23-/m0/s1 FAMZQIJWHMPNCC-SRYPRDQNSA-N 153553 US8999975, 70 Dipeptidyl peptidase 1 26 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153553 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153553&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89472053 253650673 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294801 Cc1cc(cc(C)c1F)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C24H26FN3O/c1-14-9-19(10-15(2)22(14)25)17-5-3-16(4-6-17)11-21(13-26)28-24(29)23-18-7-8-20(12-18)27-23/h3-6,9-10,18,20-21,23,27H,7-8,11-12H2,1-2H3,(H,28,29)/t18-,20+,21-,23-/m0/s1 JELJRRAKVPBNET-SQMWVJLWSA-N 153554 US8999975, 71 Dipeptidyl peptidase 1 10 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153554 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153554&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89472045 253650674 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294802 Clc1cc(ccc1C#N)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C23H21ClN4O/c24-21-11-16(5-6-18(21)12-25)15-3-1-14(2-4-15)9-20(13-26)28-23(29)22-17-7-8-19(10-17)27-22/h1-6,11,17,19-20,22,27H,7-10H2,(H,28,29)/t17-,19+,20-,22-/m0/s1 XZLYQHUFYHOOCI-UFGBVDADSA-N 153555 US8999975, 72 Dipeptidyl peptidase 1 7 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153555&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89472046 253650675 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294803 O=C(N[C@@H](Cc1ccc(cc1)-c1ccccc1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C22H23N3O/c23-14-20(25-22(26)21-18-10-11-19(13-18)24-21)12-15-6-8-17(9-7-15)16-4-2-1-3-5-16/h1-9,18-21,24H,10-13H2,(H,25,26)/t18-,19+,20-,21-/m0/s1 SAXAMVZZDYRTOQ-WOZUAGRISA-N 153556 US8999975, 73 Dipeptidyl peptidase 1 21 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153556 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153556&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89472047 253650676 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294804 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2C(=O)CCc2c1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C25H25N3O2/c26-14-21(28-25(30)24-19-5-8-20(13-19)27-24)11-15-1-3-16(4-2-15)17-6-9-22-18(12-17)7-10-23(22)29/h1-4,6,9,12,19-21,24,27H,5,7-8,10-11,13H2,(H,28,30)/t19-,20+,21-,24-/m0/s1 KGWZJXYUHORUBO-XARGGIHNSA-N 153557 US8999975, 74 Dipeptidyl peptidase 1 6 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153557 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153557&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89472054 253650677 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294805 COc1cccc(n1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C22H24N4O2/c1-28-20-4-2-3-19(26-20)15-7-5-14(6-8-15)11-18(13-23)25-22(27)21-16-9-10-17(12-16)24-21/h2-8,16-18,21,24H,9-12H2,1H3,(H,25,27)/t16-,17+,18-,21-/m0/s1 ZWDYSDQSGFRIDL-NYUBLWNDSA-N 153558 US8999975, 75 Dipeptidyl peptidase 1 41 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153558&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89472055 253650678 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294806 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2CCC(=O)c2c1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C25H25N3O2/c26-14-21(28-25(30)24-19-7-9-20(12-19)27-24)11-15-1-3-16(4-2-15)18-6-5-17-8-10-23(29)22(17)13-18/h1-6,13,19-21,24,27H,7-12H2,(H,28,30)/t19-,20+,21-,24-/m0/s1 NIMRNASKMAHAKY-XARGGIHNSA-N 153559 US8999975, 76 Dipeptidyl peptidase 1 75 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153559 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153559&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89472049 253650679 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294807 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cn1)C#N)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C22H21N5O/c23-11-15-3-8-20(25-13-15)16-4-1-14(2-5-16)9-19(12-24)27-22(28)21-17-6-7-18(10-17)26-21/h1-5,8,13,17-19,21,26H,6-7,9-10H2,(H,27,28)/t17-,18+,19-,21-/m0/s1 SHSQXBQWJXJSEZ-JTJHWIPRSA-N 153560 US8999975, 77 Dipeptidyl peptidase 1 21 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153560&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89472051 253650680 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294808 O=C(N[C@@H](Cc1ccc(cc1)-c1cccc(n1)C#N)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C22H21N5O/c23-12-18-2-1-3-20(25-18)15-6-4-14(5-7-15)10-19(13-24)27-22(28)21-16-8-9-17(11-16)26-21/h1-7,16-17,19,21,26H,8-11H2,(H,27,28)/t16-,17+,19-,21-/m0/s1 SHQPSFNSEFGFHA-NZGUISNBSA-N 153561 US8999975, 78 Dipeptidyl peptidase 1 29 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153561 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153561&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89472057 253650681 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294809 O=C(N[C@@H](Cc1ccc(cc1)-c1ccnc(c1)C#N)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C22H21N5O/c23-12-19-10-16(7-8-25-19)15-3-1-14(2-4-15)9-20(13-24)27-22(28)21-17-5-6-18(11-17)26-21/h1-4,7-8,10,17-18,20-21,26H,5-6,9,11H2,(H,27,28)/t17-,18+,20-,21-/m0/s1 UNHYOFVDBZVSEV-YHELAOLJSA-N 153562 US8999975, 79 Dipeptidyl peptidase 1 16 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153562 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153562&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89472052 253650682 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294810 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2CCNC(=O)c2c1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C25H26N4O2/c26-14-21(29-25(31)23-19-7-8-20(12-19)28-23)11-15-1-3-16(4-2-15)18-6-5-17-9-10-27-24(30)22(17)13-18/h1-6,13,19-21,23,28H,7-12H2,(H,27,30)(H,29,31)/t19-,20+,21-,23-/m0/s1 PXHNPPUIBSAJTQ-KGSLCBSSSA-N 153563 US8999975, 80 Dipeptidyl peptidase 1 54 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153563 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153563&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471944 253650683 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294811 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2ncsc2c1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C23H22N4OS/c24-12-19(27-23(28)22-17-5-7-18(10-17)26-22)9-14-1-3-15(4-2-14)16-6-8-20-21(11-16)29-13-25-20/h1-4,6,8,11,13,17-19,22,26H,5,7,9-10H2,(H,27,28)/t17-,18+,19-,22-/m0/s1 UDUDORBEVXJVPZ-WEMPKCCASA-N 153564 US8999975, 81 Dipeptidyl peptidase 1 15 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153564&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89667246 253650684 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294812 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2NC(=O)CCc2c1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C25H26N4O2/c26-14-21(28-25(31)24-19-5-8-20(13-19)27-24)11-15-1-3-16(4-2-15)17-6-9-22-18(12-17)7-10-23(30)29-22/h1-4,6,9,12,19-21,24,27H,5,7-8,10-11,13H2,(H,28,31)(H,29,30)/t19-,20+,21-,24-/m0/s1 OJOMVKILHAPJRP-XARGGIHNSA-N 153565 US8999975, 82 Dipeptidyl peptidase 1 11 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153565 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153565&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471942 253681147 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294813 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2NC(=O)OCc2c1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C24H24N4O3/c25-12-20(27-23(29)22-17-5-7-19(11-17)26-22)9-14-1-3-15(4-2-14)16-6-8-21-18(10-16)13-31-24(30)28-21/h1-4,6,8,10,17,19-20,22,26H,5,7,9,11,13H2,(H,27,29)(H,28,30)/t17-,19+,20-,22-/m0/s1 BHRJSOSRCBYVQE-UFGBVDADSA-N 153566 US8999975, 83 Dipeptidyl peptidase 1 6 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153566 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153566&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471941 253650686 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294814 O=C(N[C@@H](Cc1ccc(cc1)-c1ccnnc1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C20H21N5O/c21-11-18(25-20(26)19-15-5-6-17(10-15)24-19)9-13-1-3-14(4-2-13)16-7-8-22-23-12-16/h1-4,7-8,12,15,17-19,24H,5-6,9-10H2,(H,25,26)/t15-,17+,18-,19-/m0/s1 OADCHMOEPCRZBN-NQYYFHDYSA-N 153567 US8999975, 84 Dipeptidyl peptidase 1 123 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153567 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153567&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471940 253650687 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294815 CS(=O)(=O)c1ccc(nc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C22H24N4O3S/c1-30(28,29)19-8-9-20(24-13-19)15-4-2-14(3-5-15)10-18(12-23)26-22(27)21-16-6-7-17(11-16)25-21/h2-5,8-9,13,16-18,21,25H,6-7,10-11H2,1H3,(H,26,27)/t16-,17+,18-,21-/m0/s1 RBZZNFNJNPCUHN-NYUBLWNDSA-N 153568 US8999975, 85 Dipeptidyl peptidase 1 24 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153568&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471943 253650688 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294816 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2cncnc2c1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C24H23N5O/c25-12-21(29-24(30)23-18-7-8-20(10-18)28-23)9-15-1-3-16(4-2-15)17-5-6-19-13-26-14-27-22(19)11-17/h1-6,11,13-14,18,20-21,23,28H,7-10H2,(H,29,30)/t18-,20+,21-,23-/m0/s1 PQXYDDPTXAXROC-SQMWVJLWSA-N 153569 US8999975, 86 Dipeptidyl peptidase 1 16 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153569 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153569&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89472133 253650689 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294817 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2OCC(=O)Nc2c1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C24H24N4O3/c25-12-19(27-24(30)23-17-5-7-18(10-17)26-23)9-14-1-3-15(4-2-14)16-6-8-21-20(11-16)28-22(29)13-31-21/h1-4,6,8,11,17-19,23,26H,5,7,9-10,13H2,(H,27,30)(H,28,29)/t17-,18+,19-,23-/m0/s1 FGEMZCGLLXOXDM-YWNPBTLJSA-N 153570 US8999975, 87 Dipeptidyl peptidase 1 13 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153570 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153570&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89472137 253650690 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294818 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2NC(=O)COc2c1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C24H24N4O3/c25-12-19(27-24(30)23-17-5-7-18(10-17)26-23)9-14-1-3-15(4-2-14)16-6-8-20-21(11-16)31-13-22(29)28-20/h1-4,6,8,11,17-19,23,26H,5,7,9-10,13H2,(H,27,30)(H,28,29)/t17-,18+,19-,23-/m0/s1 MNQDWRSGLDCMOR-YWNPBTLJSA-N 153571 US8999975, 88 Dipeptidyl peptidase 1 13 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153571 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153571&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89472138 253650691 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294819 CS(=O)(=O)c1ccc(cn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C22H24N4O3S/c1-30(28,29)20-9-7-17(13-24-20)15-4-2-14(3-5-15)10-19(12-23)26-22(27)21-16-6-8-18(11-16)25-21/h2-5,7,9,13,16,18-19,21,25H,6,8,10-11H2,1H3,(H,26,27)/t16-,18+,19-,21-/m0/s1 WVRGGTHVDOHXER-KRQVXIAISA-N 153572 US8999975, 89 Dipeptidyl peptidase 1 23 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153572 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153572&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89472134 253650692 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294820 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2CCC(=O)Nc2c1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C25H26N4O2/c26-14-21(28-25(31)24-19-7-9-20(12-19)27-24)11-15-1-3-16(4-2-15)18-6-5-17-8-10-23(30)29-22(17)13-18/h1-6,13,19-21,24,27H,7-12H2,(H,28,31)(H,29,30)/t19-,20+,21-,24-/m0/s1 LWLDEWHHNMHBHU-XARGGIHNSA-N 153573 US8999975, 90 Dipeptidyl peptidase 1 14 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153573 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153573&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89472139 253650693 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294821 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2CNC(=O)c2c1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C24H24N4O2/c25-12-20(28-24(30)22-17-7-8-19(10-17)27-22)9-14-1-3-15(4-2-14)16-5-6-18-13-26-23(29)21(18)11-16/h1-6,11,17,19-20,22,27H,7-10,13H2,(H,26,29)(H,28,30)/t17-,19+,20-,22-/m0/s1 FYCCUWDNVWYGLW-UFGBVDADSA-N 153574 US8999975, 91 Dipeptidyl peptidase 1 58 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153574 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153574&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89472135 253650694 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294822 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2COCc2c1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C24H25N3O2/c25-12-22(27-24(28)23-18-7-8-21(11-18)26-23)9-15-1-3-16(4-2-15)17-5-6-19-13-29-14-20(19)10-17/h1-6,10,18,21-23,26H,7-9,11,13-14H2,(H,27,28)/t18-,21+,22-,23-/m0/s1 GCXSGUXTOAGFNO-AWDZXFJFSA-N 153575 US8999975, 92 Dipeptidyl peptidase 1 8 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153575&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89472136 253650695 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294823 CN(C)c1ccc(cn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C23H27N5O/c1-28(2)21-10-8-18(14-25-21)16-5-3-15(4-6-16)11-20(13-24)27-23(29)22-17-7-9-19(12-17)26-22/h3-6,8,10,14,17,19-20,22,26H,7,9,11-12H2,1-2H3,(H,27,29)/t17-,19+,20-,22-/m0/s1 WVKRCOVSCTUPQZ-UFGBVDADSA-N 153576 US8999975, 93 Dipeptidyl peptidase 1 34 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153576 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153576&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89472062 253650696 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294824 O=C(N[C@@H](Cc1ccc(cc1)-c1cnc(cn1)C#N)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C21H20N6O/c22-9-17(27-21(28)20-15-5-6-16(8-15)26-20)7-13-1-3-14(4-2-13)19-12-24-18(10-23)11-25-19/h1-4,11-12,15-17,20,26H,5-8H2,(H,27,28)/t15-,16+,17-,20-/m0/s1 OKOLCJIWKIXIAJ-CLWJZODNSA-N 153577 US8999975, 94 Dipeptidyl peptidase 1 24 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153577 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153577&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89472063 253650697 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294825 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2OCCOc2c1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C24H25N3O3/c25-14-20(27-24(28)23-18-5-7-19(12-18)26-23)11-15-1-3-16(4-2-15)17-6-8-21-22(13-17)30-10-9-29-21/h1-4,6,8,13,18-20,23,26H,5,7,9-12H2,(H,27,28)/t18-,19+,20-,23-/m0/s1 GOBHQSQQWPCRDK-SRYPRDQNSA-N 153578 US8999975, 95 Dipeptidyl peptidase 1 31 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153578&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89472058 253650698 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294826 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2[nH]ncc2c1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 153579 US8999975, 96 Dipeptidyl peptidase 1 17 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153579&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89472061 253650699 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294827 Cn1cnc2cc(ccc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C24H25N5O/c1-29-14-26-21-12-17(7-9-22(21)29)16-4-2-15(3-5-16)10-20(13-25)28-24(30)23-18-6-8-19(11-18)27-23/h2-5,7,9,12,14,18-20,23,27H,6,8,10-11H2,1H3,(H,28,30)/t18-,19+,20-,23-/m0/s1 YEIQCBPYWXYPEL-SRYPRDQNSA-N 153580 US8999975, 97 Dipeptidyl peptidase 1 90 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153580 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153580&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89472060 253650700 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294828 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)-n1ccnc1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C25H25N5O/c26-15-22(29-25(31)24-20-5-8-21(14-20)28-24)13-17-1-3-18(4-2-17)19-6-9-23(10-7-19)30-12-11-27-16-30/h1-4,6-7,9-12,16,20-22,24,28H,5,8,13-14H2,(H,29,31)/t20-,21+,22-,24-/m0/s1 YJLDLFPPTFEFRU-KHUIQGCPSA-N 153581 US8999975, 98 Dipeptidyl peptidase 1 20 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153581 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153581&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89472059 253650701 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294829 Cc1n[nH]c2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 153582 US8999975, 99 Dipeptidyl peptidase 1 13 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153582 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153582&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471807 253650702 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294830 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2C(=O)OCc2c1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C24H23N3O3/c25-12-20(27-23(28)22-17-5-7-19(11-17)26-22)9-14-1-3-15(4-2-14)16-6-8-21-18(10-16)13-30-24(21)29/h1-4,6,8,10,17,19-20,22,26H,5,7,9,11,13H2,(H,27,28)/t17-,19+,20-,22-/m0/s1 PFKMGTMZODMICS-UFGBVDADSA-N 153583 US8999975, 100 Dipeptidyl peptidase 1 2 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153583 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153583&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471809 253650703 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294831 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)-c1cc[nH]n1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 153584 US8999975, 101 Dipeptidyl peptidase 1 76 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153584 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153584&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471802 253650704 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294832 O=C(N[C@@H](Cc1ccc(cc1)-c1cnc(nc1)C#N)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C21H20N6O/c22-9-18(27-21(28)20-15-5-6-17(8-15)26-20)7-13-1-3-14(4-2-13)16-11-24-19(10-23)25-12-16/h1-4,11-12,15,17-18,20,26H,5-8H2,(H,27,28)/t15-,17+,18-,20-/m0/s1 QRFSWUXEIFCPSH-NFBUACBFSA-N 153585 US8999975, 102 Dipeptidyl peptidase 1 34 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153585 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153585&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471806 253650705 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294833 Oc1ccc(cn1)-c1cn(nn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C23H23N7O2/c24-11-18(27-23(32)22-15-3-5-17(10-15)26-22)9-14-1-6-19(7-2-14)30-13-20(28-29-30)16-4-8-21(31)25-12-16/h1-2,4,6-8,12-13,15,17-18,22,26H,3,5,9-10H2,(H,25,31)(H,27,32)/t15-,17+,18-,22-/m0/s1 UUBPBKLYWYAGRG-PBWVOLNLSA-N 153586 US8999975, 103 Dipeptidyl peptidase 1 69 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153586 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153586&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471810 253650706 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294834 Cc1cc(cnc1C#N)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C23H23N5O/c1-14-8-18(13-26-21(14)12-25)16-4-2-15(3-5-16)9-20(11-24)28-23(29)22-17-6-7-19(10-17)27-22/h2-5,8,13,17,19-20,22,27H,6-7,9-10H2,1H3,(H,28,29)/t17-,19+,20-,22-/m0/s1 JKHLHUGYYUUGJH-UFGBVDADSA-N 153587 US8999975, 104 Dipeptidyl peptidase 1 8 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153587 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153587&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471805 253650707 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294835 Clc1ccc(nc1)-c1cn(nn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C23H22ClN7O/c24-16-4-8-20(26-12-16)21-13-31(30-29-21)19-6-1-14(2-7-19)9-18(11-25)28-23(32)22-15-3-5-17(10-15)27-22/h1-2,4,6-8,12-13,15,17-18,22,27H,3,5,9-10H2,(H,28,32)/t15-,17+,18-,22-/m0/s1 MKOKZJOTQDYTRH-PBWVOLNLSA-N 153588 US8999975, 105 Dipeptidyl peptidase 1 104 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153588 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153588&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471793 253650708 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294836 O=C(N[C@@H](Cc1ccc(cc1)-n1cc(nn1)-c1ccc2occc2c1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C26H24N6O2/c27-14-21(29-26(33)25-19-3-5-20(13-19)28-25)11-16-1-6-22(7-2-16)32-15-23(30-31-32)17-4-8-24-18(12-17)9-10-34-24/h1-2,4,6-10,12,15,19-21,25,28H,3,5,11,13H2,(H,29,33)/t19-,20+,21-,25-/m0/s1 YJOMYHHSFKERAR-PDFGSZSQSA-N 153589 US8999975, 106 Dipeptidyl peptidase 1 27 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153589&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471789 253650709 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294837 CC(C)Oc1ccc(nc1)-c1cn(nn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C26H29N7O2/c1-16(2)35-22-9-10-23(28-14-22)24-15-33(32-31-24)21-7-3-17(4-8-21)11-20(13-27)30-26(34)25-18-5-6-19(12-18)29-25/h3-4,7-10,14-16,18-20,25,29H,5-6,11-12H2,1-2H3,(H,30,34)/t18-,19+,20-,25-/m0/s1 IITWFFIVNJQPAG-ZDQHKECQSA-N 153590 US8999975, 107 Dipeptidyl peptidase 1 118 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153590 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153590&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471790 253650710 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294838 COc1ccc(cc1OC)-c1cn(nn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C26H28N6O3/c1-34-23-10-6-17(13-24(23)35-2)22-15-32(31-30-22)21-8-3-16(4-9-21)11-20(14-27)29-26(33)25-18-5-7-19(12-18)28-25/h3-4,6,8-10,13,15,18-20,25,28H,5,7,11-12H2,1-2H3,(H,29,33)/t18-,19+,20-,25-/m0/s1 ARRIOZFZAKFELA-ZDQHKECQSA-N 153591 US8999975, 108 Dipeptidyl peptidase 1 24 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153591 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153591&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471791 253650711 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294839 CC(=O)c1cn(nn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C20H22N6O2/c1-12(27)18-11-26(25-24-18)17-6-2-13(3-7-17)8-16(10-21)23-20(28)19-14-4-5-15(9-14)22-19/h2-3,6-7,11,14-16,19,22H,4-5,8-9H2,1H3,(H,23,28)/t14-,15+,16-,19-/m0/s1 QQXYJESRPPCGFU-RCJHGTSTSA-N 153592 US8999975, 109 Dipeptidyl peptidase 1 25 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153592 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153592&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471792 253650712 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294840 CC(C)Oc1ccc(cc1)-c1cn(nn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C27H30N6O2/c1-17(2)35-24-11-6-19(7-12-24)25-16-33(32-31-25)23-9-3-18(4-10-23)13-22(15-28)30-27(34)26-20-5-8-21(14-20)29-26/h3-4,6-7,9-12,16-17,20-22,26,29H,5,8,13-14H2,1-2H3,(H,30,34)/t20-,21+,22-,26-/m0/s1 SJRVYYZVYCYBCX-MSZDEVHKSA-N 153593 US8999975, 110 Dipeptidyl peptidase 1 42 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153593 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153593&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89472151 253650713 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294841 COc1ncc(cn1)-c1cn(nn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C23H24N8O2/c1-33-23-25-11-16(12-26-23)20-13-31(30-29-20)19-6-2-14(3-7-19)8-18(10-24)28-22(32)21-15-4-5-17(9-15)27-21/h2-3,6-7,11-13,15,17-18,21,27H,4-5,8-9H2,1H3,(H,28,32)/t15-,17+,18-,21-/m0/s1 RBRLAMQINSERHU-DKXUYOFUSA-N 153594 US8999975, 111 Dipeptidyl peptidase 1 44 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153594 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153594&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89472145 253650714 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294842 O=C(N[C@@H](Cc1ccc(cc1)-n1cc(nn1)-c1ccc2[nH]ccc2c1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 153595 US8999975, 112 Dipeptidyl peptidase 1 13 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153595 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153595&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89472144 253650715 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294843 O=C(N[C@@H](Cc1ccc(cc1)-n1cc(nn1)-c1ccncc1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C23H23N7O/c24-13-19(27-23(31)22-17-3-4-18(12-17)26-22)11-15-1-5-20(6-2-15)30-14-21(28-29-30)16-7-9-25-10-8-16/h1-2,5-10,14,17-19,22,26H,3-4,11-12H2,(H,27,31)/t17-,18+,19-,22-/m0/s1 HRKFNCUUCATSJV-WEMPKCCASA-N 153596 US8999975, 113 Dipeptidyl peptidase 1 30 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153596 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153596&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89472147 253650716 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294844 CCc1nc(no1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C20H23N5O2/c1-2-17-24-19(25-27-17)13-5-3-12(4-6-13)9-16(11-21)23-20(26)18-14-7-8-15(10-14)22-18/h3-6,14-16,18,22H,2,7-10H2,1H3,(H,23,26)/t14-,15+,16-,18-/m0/s1 NYIFUPCPKNDWSZ-DFGXFYAUSA-N 153597 US8999975, 114::US8999975, 116 Dipeptidyl peptidase 1 64 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153597&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471967 253650717 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294845 COCc1nc(no1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C20H23N5O3/c1-27-11-17-24-19(25-28-17)13-4-2-12(3-5-13)8-16(10-21)23-20(26)18-14-6-7-15(9-14)22-18/h2-5,14-16,18,22H,6-9,11H2,1H3,(H,23,26)/t14-,15+,16-,18-/m0/s1 ALZDMNKMNBSVNA-DFGXFYAUSA-N 153598 US8999975, 115 Dipeptidyl peptidase 1 71 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153598&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471974 253650718 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294846 CCc1nc(no1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C20H23N5O2/c1-2-17-24-19(25-27-17)13-5-3-12(4-6-13)9-16(11-21)23-20(26)18-14-7-8-15(10-14)22-18/h3-6,14-16,18,22H,2,7-10H2,1H3,(H,23,26)/t14-,15+,16-,18-/m0/s1 NYIFUPCPKNDWSZ-DFGXFYAUSA-N 153597 US8999975, 114::US8999975, 116 Dipeptidyl peptidase 1 46 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153597&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471967 253650717 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294847 Cc1n[nH]c2ccc(cc12)-c1cn(nn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 153600 US8999975, 117 Dipeptidyl peptidase 1 9 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153600 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153600&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471969 253650719 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294848 Cn1ccc2cc(ccc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C25H26N4O/c1-29-11-10-19-13-18(7-9-23(19)29)17-4-2-16(3-5-17)12-22(15-26)28-25(30)24-20-6-8-21(14-20)27-24/h2-5,7,9-11,13,20-22,24,27H,6,8,12,14H2,1H3,(H,28,30)/t20-,21+,22-,24-/m0/s1 MACZUNVGPMDQPB-KHUIQGCPSA-N 153601 US8999975, 118 Dipeptidyl peptidase 1 89 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153601 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153601&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471971 253650720 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294849 CN1Cc2cc(ccc2C1=O)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C25H26N4O2/c1-29-14-19-11-17(7-9-22(19)25(29)31)16-4-2-15(3-5-16)10-21(13-26)28-24(30)23-18-6-8-20(12-18)27-23/h2-5,7,9,11,18,20-21,23,27H,6,8,10,12,14H2,1H3,(H,28,30)/t18-,20+,21-,23-/m0/s1 OPAUEZURZALIRI-SQMWVJLWSA-N 153602 US8999975, 119 Dipeptidyl peptidase 1 15 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153602&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471934 253650721 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294850 CN1C(=O)C(=O)c2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C25H24N4O3/c1-29-21-12-16(7-9-20(21)23(30)25(29)32)15-4-2-14(3-5-15)10-19(13-26)28-24(31)22-17-6-8-18(11-17)27-22/h2-5,7,9,12,17-19,22,27H,6,8,10-11H2,1H3,(H,28,31)/t17-,18+,19-,22-/m0/s1 MXCXKXBYNYVRHA-WEMPKCCASA-N 153603 US8999975, 120 Dipeptidyl peptidase 1 3 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153603 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153603&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 71506867 253650722 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294851 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2oc(=O)[nH]c2c1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 153604 US8999975, 121 Dipeptidyl peptidase 1 4 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153604 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153604&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471925 253650723 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294852 COCCN1C(=O)Cc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C27H30N4O3/c1-34-11-10-31-24-14-19(6-7-20(24)15-25(31)32)18-4-2-17(3-5-18)12-23(16-28)30-27(33)26-21-8-9-22(13-21)29-26/h2-7,14,21-23,26,29H,8-13,15H2,1H3,(H,30,33)/t21-,22+,23-,26-/m0/s1 TZZUEQRCYWEUTO-LNEBKTTKSA-N 153605 US8999975, 122 Dipeptidyl peptidase 1 7 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153605 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153605&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471933 253650724 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294853 CS(=O)(=O)c1cc(ccc1C#N)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C24H24N4O3S/c1-32(30,31)22-12-17(6-7-19(22)13-25)16-4-2-15(3-5-16)10-21(14-26)28-24(29)23-18-8-9-20(11-18)27-23/h2-7,12,18,20-21,23,27H,8-11H2,1H3,(H,28,29)/t18-,20+,21-,23-/m0/s1 GRVOGCSGQQMQLZ-SQMWVJLWSA-N 153606 US8999975, 123 Dipeptidyl peptidase 1 7 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153606 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153606&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91970497 253650725 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294854 CN1C(=O)Cc2cc(ccc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C25H26N4O2/c1-29-22-9-7-17(11-19(22)13-23(29)30)16-4-2-15(3-5-16)10-21(14-26)28-25(31)24-18-6-8-20(12-18)27-24/h2-5,7,9,11,18,20-21,24,27H,6,8,10,12-13H2,1H3,(H,28,31)/t18-,20+,21-,24-/m0/s1 QJAPUFXXRAYKIV-UQWVPHONSA-N 153607 US8999975, 124 Dipeptidyl peptidase 1 8 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153607 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153607&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91970498 253650726 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294855 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2CC(=O)Nc2c1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C24H24N4O2/c25-13-20(27-24(30)23-18-7-8-19(10-18)26-23)9-14-1-3-15(4-2-14)16-5-6-17-12-22(29)28-21(17)11-16/h1-6,11,18-20,23,26H,7-10,12H2,(H,27,30)(H,28,29)/t18-,19+,20-,23-/m0/s1 CWMHZGKYRHNDRJ-SRYPRDQNSA-N 153608 US8999975, 125 Dipeptidyl peptidase 1 8 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153608&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91970499 253650727 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294856 CC(C)N1C(=O)Cc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C27H30N4O2/c1-16(2)31-24-13-19(7-8-20(24)14-25(31)32)18-5-3-17(4-6-18)11-23(15-28)30-27(33)26-21-9-10-22(12-21)29-26/h3-8,13,16,21-23,26,29H,9-12,14H2,1-2H3,(H,30,33)/t21-,22+,23-,26-/m0/s1 NHLWCGGOMCOSOK-LNEBKTTKSA-N 153609 US8999975, 126 Dipeptidyl peptidase 1 9 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153609 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153609&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471975 253650728 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294857 CC(=O)N1C(=O)Cc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C26H26N4O3/c1-15(31)30-23-12-18(6-7-19(23)13-24(30)32)17-4-2-16(3-5-17)10-22(14-27)29-26(33)25-20-8-9-21(11-20)28-25/h2-7,12,20-22,25,28H,8-11,13H2,1H3,(H,29,33)/t20-,21+,22-,25-/m0/s1 LXVLPCSCBFESBW-MTQWNXOMSA-N 153610 US8999975, 127 Dipeptidyl peptidase 1 10 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153610 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153610&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91970500 253650729 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294858 CCN1C(=O)Cc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C26H28N4O2/c1-2-30-23-13-18(7-8-19(23)14-24(30)31)17-5-3-16(4-6-17)11-22(15-27)29-26(32)25-20-9-10-21(12-20)28-25/h3-8,13,20-22,25,28H,2,9-12,14H2,1H3,(H,29,32)/t20-,21+,22-,25-/m0/s1 DEWRDGXGDPDGAX-MTQWNXOMSA-N 153611 US8999975, 128 Dipeptidyl peptidase 1 10 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153611 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153611&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89472150 253650730 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294859 O[C@H]1C[C@H]2C[C@@H]1N[C@@H]2C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(C#N)c(F)c1)C#N InChI=1S/C23H21FN4O2/c24-19-8-15(5-6-16(19)11-25)14-3-1-13(2-4-14)7-18(12-26)27-23(30)22-17-9-20(28-22)21(29)10-17/h1-6,8,17-18,20-22,28-29H,7,9-10H2,(H,27,30)/t17-,18+,20+,21+,22+/m1/s1 ZMJPMXXVIHXCKJ-NQOGSSOHSA-N 153533 BDBM153612::US8999975, 50 Dipeptidyl peptidase 1 14 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153533&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471968 253650653 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294860 COCCCN1C(=O)Cc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C28H32N4O3/c1-35-12-2-11-32-25-15-20(7-8-21(25)16-26(32)33)19-5-3-18(4-6-19)13-24(17-29)31-28(34)27-22-9-10-23(14-22)30-27/h3-8,15,22-24,27,30H,2,9-14,16H2,1H3,(H,31,34)/t22-,23+,24-,27-/m0/s1 FMTQWCIBQDNGGD-LAOBSVPGSA-N 153613 US8999975, 130 Dipeptidyl peptidase 1 16 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153613 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153613&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89472142 253650732 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294861 CN1C(=O)Cc2c1cccc2-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C25H26N4O2/c1-29-22-4-2-3-20(21(22)13-23(29)30)16-7-5-15(6-8-16)11-19(14-26)28-25(31)24-17-9-10-18(12-17)27-24/h2-8,17-19,24,27H,9-13H2,1H3,(H,28,31)/t17-,18+,19-,24-/m0/s1 RBWALDAYWHXKHV-YDLHNXBPSA-N 153614 US8999975, 131 Dipeptidyl peptidase 1 18 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153614 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153614&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91970501 253650733 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294862 Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C24H24N4O3/c1-28-20-12-16(7-9-21(20)31-24(28)30)15-4-2-14(3-5-15)10-19(13-25)27-23(29)22-17-6-8-18(11-17)26-22/h2-5,7,9,12,17-19,22,26H,6,8,10-11H2,1H3,(H,27,29)/t17-,18+,19-,22-/m0/s1 NPILXGMBXWBKQW-WEMPKCCASA-N 153615 US8999975, 132 Dipeptidyl peptidase 1 28 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153615 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153615&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89472143 253650734 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294863 CN1C(=O)C(C)(O)c2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C26H28N4O3/c1-26(33)21-10-8-17(13-22(21)30(2)25(26)32)16-5-3-15(4-6-16)11-20(14-27)29-24(31)23-18-7-9-19(12-18)28-23/h3-6,8,10,13,18-20,23,28,33H,7,9,11-12H2,1-2H3,(H,29,31)/t18-,19+,20-,23-,26?/m0/s1 KRMCABNMSJTYBA-IBDJNKTASA-N 153616 US8999975, 133 Dipeptidyl peptidase 1 30 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153616 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153616&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471979 253650735 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294864 CN1C(=O)C(C)(C)c2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C27H30N4O2/c1-27(2)22-11-9-18(14-23(22)31(3)26(27)33)17-6-4-16(5-7-17)12-21(15-28)30-25(32)24-19-8-10-20(13-19)29-24/h4-7,9,11,14,19-21,24,29H,8,10,12-13H2,1-3H3,(H,30,32)/t19-,20+,21-,24-/m0/s1 XFUACXJRQGHGIS-XARGGIHNSA-N 153617 US8999975, 134 Dipeptidyl peptidase 1 39 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153617&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471983 253650736 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294865 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2CNS(=O)(=O)c2c1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C23H24N4O3S/c24-12-20(27-23(28)22-17-7-8-19(10-17)26-22)9-14-1-3-15(4-2-14)16-5-6-18-13-25-31(29,30)21(18)11-16/h1-6,11,17,19-20,22,25-26H,7-10,13H2,(H,27,28)/t17-,19+,20-,22-/m0/s1 HCKNQYOWAVRZMN-UFGBVDADSA-N 153618 US8999975, 135 Dipeptidyl peptidase 1 40 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153618 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153618&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471981 253650737 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294866 O=C(N[C@@H](Cc1ccc(cc1)-c1cccc2NC(=O)Cc12)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C24H24N4O2/c25-13-18(27-24(30)23-16-8-9-17(11-16)26-23)10-14-4-6-15(7-5-14)19-2-1-3-21-20(19)12-22(29)28-21/h1-7,16-18,23,26H,8-12H2,(H,27,30)(H,28,29)/t16-,17+,18-,23-/m0/s1 LKSVVNGRFRREFT-FXKZBUDASA-N 153619 US8999975, 136 Dipeptidyl peptidase 1 47 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153619 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153619&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471980 253650738 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294867 O[C@H]1C[C@@H]2C[C@H]1[C@H](N2)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(C#N)c(F)c1)C#N InChI=1S/C23H21FN4O2/c24-20-8-15(5-6-16(20)11-25)14-3-1-13(2-4-14)7-18(12-26)28-23(30)22-19-9-17(27-22)10-21(19)29/h1-6,8,17-19,21-22,27,29H,7,9-10H2,(H,28,30)/t17-,18-,19+,21-,22-/m0/s1 XZWPTHRWDICZKP-GVMRPCBKSA-N 153620 US8999975, 137 Dipeptidyl peptidase 1 61 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153620&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471984 253650739 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294868 COC1(C)C(=O)N(C)c2cc(ccc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C27H30N4O3/c1-27(34-3)22-11-9-18(14-23(22)31(2)26(27)33)17-6-4-16(5-7-17)12-21(15-28)30-25(32)24-19-8-10-20(13-19)29-24/h4-7,9,11,14,19-21,24,29H,8,10,12-13H2,1-3H3,(H,30,32)/t19-,20+,21-,24-,27?/m0/s1 VOMLKWFKYGKCKW-HOVUYQQHSA-N 153621 US8999975, 138 Dipeptidyl peptidase 1 68 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153621&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471812 253650740 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294869 CN1Cc2ccc(cc2C1=O)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C25H26N4O2/c1-29-14-19-7-6-17(12-22(19)25(29)31)16-4-2-15(3-5-16)10-21(13-26)28-24(30)23-18-8-9-20(11-18)27-23/h2-7,12,18,20-21,23,27H,8-11,14H2,1H3,(H,28,30)/t18-,20+,21-,23-/m0/s1 ZUPGIPFTJIFTKP-SQMWVJLWSA-N 153622 US8999975, 139 Dipeptidyl peptidase 1 71 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153622&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91970502 253650741 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 294870 Fc1cc(ccc1C#N)-c1ccc(C[C@@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1 InChI=1S/C23H21FN4O/c24-21-11-16(5-6-18(21)12-25)15-3-1-14(2-4-15)9-20(13-26)28-23(29)22-17-7-8-19(10-17)27-22/h1-6,11,17,19-20,22,27H,7-10H2,(H,28,29)/t17-,19+,20+,22-/m0/s1 FTVPZFLARXLYEY-RYTRXMBJSA-N 153623 US8999975, 140 Dipeptidyl peptidase 1 362 6 25.00 C US Patent 10.7270/Q22806BZ aid1801120 US8999975 Grundl, M; Oost, T; Pautsch, A; Peters, S; Riether, D; Wienen, W Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=153623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=153623&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89471813 253650742 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 310350 CS(=O)(=O)c1cc(ccc1C#N)-c1ccc(C[C@H](NC(=O)[C@H]2NC3CCC2CC3)C#N)c(F)c1 InChI=1S/C25H25FN4O3S/c1-34(32,33)23-12-17(3-5-19(23)13-27)16-2-4-18(22(26)11-16)10-21(14-28)30-25(31)24-15-6-8-20(29-24)9-7-15/h2-5,11-12,15,20-21,24,29H,6-10H2,1H3,(H,30,31)/t15?,20?,21-,24-/m0/s1 PESMPBFESLYXPO-SKSZBOKFSA-N 138492 US8877775, 1::US9073869, 1 Dipeptidyl peptidase 1 30.1 25.00 C US Patent 10.7270/Q2J9654T aid1801391 US9073869 Anderskewitz, R; Grauert, M; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138492 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138492&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 86269133 249815717 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 310351 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2CC(=O)Nc2c1)C#N)[C@H]1NC2CCC1CC2 InChI=1S/C25H26N4O2/c26-14-21(28-25(31)24-17-7-9-20(27-24)10-8-17)11-15-1-3-16(4-2-15)18-5-6-19-13-23(30)29-22(19)12-18/h1-6,12,17,20-21,24,27H,7-11,13H2,(H,28,31)(H,29,30)/t17?,20?,21-,24-/m0/s1 ZFWQZYVYJVNWLV-WBEBZIJESA-N 138493 US8877775, 2::US9073869, 2 Dipeptidyl peptidase 1 50.1 25.00 C US Patent 10.7270/Q2J9654T aid1801391 US9073869 Anderskewitz, R; Grauert, M; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138493 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138493&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90415608 249815718 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 310352 CN1C(=O)Cc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3CC[C@@H]2CC3)C#N)cc1 InChI=1S/C26H28N4O2/c1-30-23-13-19(6-7-20(23)14-24(30)31)17-4-2-16(3-5-17)12-22(15-27)29-26(32)25-18-8-10-21(28-25)11-9-18/h2-7,13,18,21-22,25,28H,8-12,14H2,1H3,(H,29,32)/t18-,21+,22-,25-/m0/s1 GGTCSHNAVPBGDV-DHDULZGNSA-N 138494 US8877775, 4::US9073869, 4 Dipeptidyl peptidase 1 32.2 25.00 C US Patent 10.7270/Q2J9654T aid1801391 US9073869 Anderskewitz, R; Grauert, M; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138494 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138494&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90436465 249815719 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 310353 CN1C(=O)Cc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2NC3CCC2CC3)C#N)cc1 InChI=1S/C26H28N4O2/c1-30-23-13-19(6-7-20(23)14-24(30)31)17-4-2-16(3-5-17)12-22(15-27)29-26(32)25-18-8-10-21(28-25)11-9-18/h2-7,13,18,21-22,25,28H,8-12,14H2,1H3,(H,29,32)/t18?,21?,22-,25-/m0/s1 GGTCSHNAVPBGDV-OJDUGZSWSA-N 138495 US8877775, 6::US9073869, 6 Dipeptidyl peptidase 1 52.2 25.00 C US Patent 10.7270/Q2J9654T aid1801391 US9073869 Anderskewitz, R; Grauert, M; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138495&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90436465 249815720 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 310354 Fc1cc(ccc1C#N)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3CC[C@@H]2CC3)C#N)cc1 InChI=1S/C24H23FN4O/c25-22-12-18(5-6-19(22)13-26)16-3-1-15(2-4-16)11-21(14-27)29-24(30)23-17-7-9-20(28-23)10-8-17/h1-6,12,17,20-21,23,28H,7-11H2,(H,29,30)/t17-,20+,21-,23-/m0/s1 JAEPUSZQVMPGCR-OOIKZJQMSA-N 138496 US8877775, 7::US9073869, 7 Dipeptidyl peptidase 1 66.4 25.00 C US Patent 10.7270/Q2J9654T aid1801391 US9073869 Anderskewitz, R; Grauert, M; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138496&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90418514 249815721 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 310355 CS(=O)(=O)c1cc(ccc1C#N)-c1ccc(C[C@H](NC(=O)[C@H]2NC3CCC2CC3)C#N)cc1 InChI=1S/C25H26N4O3S/c1-33(31,32)23-13-19(6-7-20(23)14-26)17-4-2-16(3-5-17)12-22(15-27)29-25(30)24-18-8-10-21(28-24)11-9-18/h2-7,13,18,21-22,24,28H,8-12H2,1H3,(H,29,30)/t18?,21?,22-,24-/m0/s1 VEFUKSHSYMURRC-YRTXYGLRSA-N 138497 US8877775, 8::US9073869, 8 Dipeptidyl peptidase 1 70.2 25.00 C US Patent 10.7270/Q2J9654T aid1801391 US9073869 Anderskewitz, R; Grauert, M; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138497&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90436475 249815722 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 310356 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)[C@H]1NC2CCC1CC2 InChI=1S/C24H24N4O/c25-14-17-3-7-19(8-4-17)18-5-1-16(2-6-18)13-22(15-26)28-24(29)23-20-9-11-21(27-23)12-10-20/h1-8,20-23,27H,9-13H2,(H,28,29)/t20?,21?,22-,23-/m0/s1 HZEOMWCQPYUDTQ-BBITVKMKSA-N 138498 US8877775, 9::US9073869, 9 Dipeptidyl peptidase 1 73 25.00 C US Patent 10.7270/Q2J9654T aid1801391 US9073869 Anderskewitz, R; Grauert, M; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138498 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138498&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90436472 249815723 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 310357 CS(=O)(=O)c1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2NC3CCC2CC3)C#N)cc1 InChI=1S/C24H27N3O3S/c1-31(29,30)22-4-2-3-19(14-22)17-7-5-16(6-8-17)13-21(15-25)27-24(28)23-18-9-11-20(26-23)12-10-18/h2-8,14,18,20-21,23,26H,9-13H2,1H3,(H,27,28)/t18?,20?,21-,23-/m0/s1 CAXHANKBDIZCAM-JGAJYACASA-N 138499 US8877775, 10::US9073869, 10 Dipeptidyl peptidase 1 73.5 25.00 C US Patent 10.7270/Q2J9654T aid1801391 US9073869 Anderskewitz, R; Grauert, M; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138499&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90436473 249815724 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 310358 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2C(=O)NCc2c1)C#N)[C@H]1NC2CCC1CC2 InChI=1S/C25H26N4O2/c26-13-21(29-25(31)23-17-5-8-20(28-23)9-6-17)11-15-1-3-16(4-2-15)18-7-10-22-19(12-18)14-27-24(22)30/h1-4,7,10,12,17,20-21,23,28H,5-6,8-9,11,14H2,(H,27,30)(H,29,31)/t17?,20?,21-,23-/m0/s1 IXYJOIPTPRUCPY-MBNYALJRSA-N 138500 US8877775, 11::US9073869, 11 Dipeptidyl peptidase 1 86.7 25.00 C US Patent 10.7270/Q2J9654T aid1801391 US9073869 Anderskewitz, R; Grauert, M; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138500&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90436474 249815725 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 310359 CS(=O)(=O)Nc1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2NC3CCC2CC3)C#N)cc1 InChI=1S/C24H28N4O3S/c1-32(30,31)28-21-4-2-3-19(14-21)17-7-5-16(6-8-17)13-22(15-25)27-24(29)23-18-9-11-20(26-23)12-10-18/h2-8,14,18,20,22-23,26,28H,9-13H2,1H3,(H,27,29)/t18?,20?,22-,23-/m0/s1 PDCURQYDVFHGAB-FRZIOBBBSA-N 138501 US8877775, 12::US9073869, 12 Dipeptidyl peptidase 1 97.4 25.00 C US Patent 10.7270/Q2J9654T aid1801391 US9073869 Anderskewitz, R; Grauert, M; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138501&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90436508 249815726 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 310360 NS(=O)(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2NC3CCC2CC3)C#N)cc1 InChI=1S/C23H26N4O3S/c24-14-20(27-23(28)22-18-5-9-19(26-22)10-6-18)13-15-1-3-16(4-2-15)17-7-11-21(12-8-17)31(25,29)30/h1-4,7-8,11-12,18-20,22,26H,5-6,9-10,13H2,(H,27,28)(H2,25,29,30)/t18?,19?,20-,22-/m0/s1 NSXPQYOXGHDKCW-IRIHCNEDSA-N 138502 US8877775, 13::US9073869, 13 Dipeptidyl peptidase 1 102.3 25.00 C US Patent 10.7270/Q2J9654T aid1801391 US9073869 Anderskewitz, R; Grauert, M; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138502&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 86269343 249815727 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 310361 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2NC(=O)Cc2c1)C#N)[C@H]1NC2CCC1CC2 InChI=1S/C25H26N4O2/c26-14-21(28-25(31)24-17-5-8-20(27-24)9-6-17)11-15-1-3-16(4-2-15)18-7-10-22-19(12-18)13-23(30)29-22/h1-4,7,10,12,17,20-21,24,27H,5-6,8-9,11,13H2,(H,28,31)(H,29,30)/t17?,20?,21-,24-/m0/s1 COXAXXLYTPEMAM-WBEBZIJESA-N 138503 US8877775, 14::US9073869, 14 Dipeptidyl peptidase 1 102.8 25.00 C US Patent 10.7270/Q2J9654T aid1801391 US9073869 Anderskewitz, R; Grauert, M; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138503 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138503&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 86269539 249815728 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 310362 CS(=O)(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2NC3CCC2CC3)C#N)cc1 InChI=1S/C24H27N3O3S/c1-31(29,30)22-12-8-18(9-13-22)17-4-2-16(3-5-17)14-21(15-25)27-24(28)23-19-6-10-20(26-23)11-7-19/h2-5,8-9,12-13,19-21,23,26H,6-7,10-11,14H2,1H3,(H,27,28)/t19?,20?,21-,23-/m0/s1 AOJJBOPIQYRTLE-JRJYRQGGSA-N 138504 US8877775, 15::US9073869, 15 Dipeptidyl peptidase 1 110.5 25.00 C US Patent 10.7270/Q2J9654T aid1801391 US9073869 Anderskewitz, R; Grauert, M; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138504&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 86269540 249815729 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 310363 NC(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2NC3CCC2CC3)C#N)cc1 InChI=1S/C24H26N4O2/c25-14-21(28-24(30)22-18-9-11-20(27-22)12-10-18)13-15-1-3-16(4-2-15)17-5-7-19(8-6-17)23(26)29/h1-8,18,20-22,27H,9-13H2,(H2,26,29)(H,28,30)/t18?,20?,21-,22-/m0/s1 DJKSTDKRJHBEOC-QJWFJBDNSA-N 138505 US8877775, 16::US9073869, 16 Dipeptidyl peptidase 1 118 25.00 C US Patent 10.7270/Q2J9654T aid1801391 US9073869 Anderskewitz, R; Grauert, M; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138505 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138505&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 86269541 249815730 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 310364 CS(=O)(=O)Nc1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2NC3CCC2CC3)C#N)cc1 InChI=1S/C24H28N4O3S/c1-32(30,31)28-21-12-6-18(7-13-21)17-4-2-16(3-5-17)14-22(15-25)27-24(29)23-19-8-10-20(26-23)11-9-19/h2-7,12-13,19-20,22-23,26,28H,8-11,14H2,1H3,(H,27,29)/t19?,20?,22-,23-/m0/s1 MGSFLXHCILBYOG-AEDUHMMZSA-N 138506 US8877775, 17::US9073869, 17 Dipeptidyl peptidase 1 123.7 25.00 C US Patent 10.7270/Q2J9654T aid1801391 US9073869 Anderskewitz, R; Grauert, M; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138506 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138506&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90436468 249815731 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 310365 NC(=O)c1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2NC3CCC2CC3)C#N)cc1 InChI=1S/C24H26N4O2/c25-14-21(28-24(30)22-17-8-10-20(27-22)11-9-17)12-15-4-6-16(7-5-15)18-2-1-3-19(13-18)23(26)29/h1-7,13,17,20-22,27H,8-12H2,(H2,26,29)(H,28,30)/t17?,20?,21-,22-/m0/s1 DKVWNKVQQQEYMS-UIIOKCELSA-N 138507 US8877775, 18::US9073869, 18 Dipeptidyl peptidase 1 130.7 25.00 C US Patent 10.7270/Q2J9654T aid1801391 US9073869 Anderskewitz, R; Grauert, M; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138507 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138507&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 86269543 249815732 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 310366 CN1C(=O)Cc2cc(ccc12)-c1ccc(C[C@H](NC(=O)[C@H]2NC3CCC2CC3)C#N)cc1 InChI=1S/C26H28N4O2/c1-30-23-11-8-19(13-20(23)14-24(30)31)17-4-2-16(3-5-17)12-22(15-27)29-26(32)25-18-6-9-21(28-25)10-7-18/h2-5,8,11,13,18,21-22,25,28H,6-7,9-10,12,14H2,1H3,(H,29,32)/t18?,21?,22-,25-/m0/s1 RFWWDMICQIKALN-OJDUGZSWSA-N 138508 US8877775, 19::US9073869, 19 Dipeptidyl peptidase 1 133.7 25.00 C US Patent 10.7270/Q2J9654T aid1801391 US9073869 Anderskewitz, R; Grauert, M; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138508 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138508&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 86269544 249815733 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 310367 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2C(=O)NCCc2c1)C#N)[C@H]1NC2CCC1CC2 InChI=1S/C26H28N4O2/c27-15-22(30-26(32)24-18-5-8-21(29-24)9-6-18)13-16-1-3-17(4-2-16)19-7-10-23-20(14-19)11-12-28-25(23)31/h1-4,7,10,14,18,21-22,24,29H,5-6,8-9,11-13H2,(H,28,31)(H,30,32)/t18?,21?,22-,24-/m0/s1 OMOFSGFVCFCCSO-YRTXYGLRSA-N 138509 US8877775, 20::US9073869, 20 Dipeptidyl peptidase 1 136.7 25.00 C US Patent 10.7270/Q2J9654T aid1801391 US9073869 Anderskewitz, R; Grauert, M; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138509 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138509&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 86269745 249815734 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 310368 COCCN1C(=O)Cc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2NC3CCC2CC3)C#N)cc1 InChI=1S/C28H32N4O3/c1-35-13-12-32-25-15-21(6-7-22(25)16-26(32)33)19-4-2-18(3-5-19)14-24(17-29)31-28(34)27-20-8-10-23(30-27)11-9-20/h2-7,15,20,23-24,27,30H,8-14,16H2,1H3,(H,31,34)/t20?,23?,24-,27-/m0/s1 SDTGCFBYMNZZRM-IFBCOXBDSA-N 138510 US8877775, 21::US9073869, 21 Dipeptidyl peptidase 1 159.8 25.00 C US Patent 10.7270/Q2J9654T aid1801391 US9073869 Anderskewitz, R; Grauert, M; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138510 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138510&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90436377 249815735 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 310369 CCS(=O)(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2NC3CCC2CC3)C#N)cc1 InChI=1S/C25H29N3O3S/c1-2-32(30,31)23-13-9-19(10-14-23)18-5-3-17(4-6-18)15-22(16-26)28-25(29)24-20-7-11-21(27-24)12-8-20/h3-6,9-10,13-14,20-22,24,27H,2,7-8,11-12,15H2,1H3,(H,28,29)/t20?,21?,22-,24-/m0/s1 VYCQXWJLCVEDQL-AELPEBTASA-N 138511 US8877775, 22::US9073869, 22 Dipeptidyl peptidase 1 164.4 25.00 C US Patent 10.7270/Q2J9654T aid1801391 US9073869 Anderskewitz, R; Grauert, M; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138511 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138511&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 86269130 249815736 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 310370 Fc1cc(cc(F)c1F)-c1ccc(C[C@H](NC(=O)[C@H]2NC3CCC2CC3)C#N)cc1 InChI=1S/C23H22F3N3O/c24-19-10-16(11-20(25)21(19)26)14-3-1-13(2-4-14)9-18(12-27)29-23(30)22-15-5-7-17(28-22)8-6-15/h1-4,10-11,15,17-18,22,28H,5-9H2,(H,29,30)/t15?,17?,18-,22-/m0/s1 ASHCBEYYVNPBGG-DRHHIBKESA-N 138512 US8877775, 23::US9073869, 23 Dipeptidyl peptidase 1 243.7 25.00 C US Patent 10.7270/Q2J9654T aid1801391 US9073869 Anderskewitz, R; Grauert, M; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138512 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138512&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 86269129 249815737 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 310371 O=C(N[C@@H](Cc1ccc(cc1)-c1ccnc(c1)C#N)C#N)[C@H]1NC2CCC1CC2 InChI=1S/C23H23N5O/c24-13-20-12-18(9-10-26-20)16-3-1-15(2-4-16)11-21(14-25)28-23(29)22-17-5-7-19(27-22)8-6-17/h1-4,9-10,12,17,19,21-22,27H,5-8,11H2,(H,28,29)/t17?,19?,21-,22-/m0/s1 BVGZFLVZIKBBIE-SUOYUTEQSA-N 138513 US8877775, 24::US9073869, 24 Dipeptidyl peptidase 1 248.5 25.00 C US Patent 10.7270/Q2J9654T aid1801391 US9073869 Anderskewitz, R; Grauert, M; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138513 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138513&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 86269131 249815738 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 310372 CN1Cc2ccc(cc2C1)-c1ccc(C[C@H](NC(=O)[C@H]2NC3CCC2CC3)C#N)c(F)c1 InChI=1S/C26H29FN4O/c1-31-14-20-5-3-17(10-21(20)15-31)18-2-4-19(24(27)12-18)11-23(13-28)30-26(32)25-16-6-8-22(29-25)9-7-16/h2-5,10,12,16,22-23,25,29H,6-9,11,14-15H2,1H3,(H,30,32)/t16?,22?,23-,25-/m0/s1 MERRSYSCRGNVPA-RPPMGDBSSA-N 138514 US8877775, 25::US9073869, 25 Dipeptidyl peptidase 1 98 25.00 C US Patent 10.7270/Q2J9654T aid1801391 US9073869 Anderskewitz, R; Grauert, M; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138514&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 86269132 249815739 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 310373 CS(=O)(=O)c1ccc(cc1C#N)-c1ccc(C[C@H](NC(=O)C2NC3CCC2CC3)C#N)c(F)c1 InChI=1S/C25H25FN4O3S/c1-34(32,33)23-9-6-16(10-19(23)13-27)17-2-3-18(22(26)12-17)11-21(14-28)30-25(31)24-15-4-7-20(29-24)8-5-15/h2-3,6,9-10,12,15,20-21,24,29H,4-5,7-8,11H2,1H3,(H,30,31)/t15?,20?,21-,24?/m0/s1 TXKVDXAWFGASKU-DQLVKDCISA-N 138515 US8877775, 26::US9073869, 26 Dipeptidyl peptidase 1 27.8 25.00 C US Patent 10.7270/Q2J9654T aid1801391 US9073869 Anderskewitz, R; Grauert, M; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138515&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 78210289 249815740 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 310374 CN1Cc2cc(ccc2S1(=O)=O)-c1ccc(C[C@H](NC(=O)[C@H]2NC3CCC2CC3)C#N)c(F)c1 InChI=1S/C25H27FN4O3S/c1-30-14-19-10-16(6-9-23(19)34(30,32)33)17-2-3-18(22(26)12-17)11-21(13-27)29-25(31)24-15-4-7-20(28-24)8-5-15/h2-3,6,9-10,12,15,20-21,24,28H,4-5,7-8,11,14H2,1H3,(H,29,31)/t15?,20?,21-,24-/m0/s1 SVTGEWLDLCDWFZ-SKSZBOKFSA-N 138516 US8877775, 27::US9073869, 27 Dipeptidyl peptidase 1 73.3 25.00 C US Patent 10.7270/Q2J9654T aid1801391 US9073869 Anderskewitz, R; Grauert, M; Grundl, M; Oost, T; Pautsch, A; Peters, S Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138516 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138516&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90436479 249815741 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50029917 CS(=O)(=O)\C=C\C(Cc1ccccc1)NC(=O)CN InChI=1S/C13H18N2O3S/c1-19(17,18)8-7-12(15-13(16)10-14)9-11-5-3-2-4-6-11/h2-8,12H,9-10,14H2,1H3,(H,15,16)/b8-7+ DLBCEDMSCPLRMY-BQYQJAHWSA-N 50026018 2-Amino-N-(1-benzyl-3-methanesulfonyl-allyl)-acetamide::CHEMBL13279 Dipeptidyl peptidase 1 180000 ChEMBL 10.1021/jm00151a018 10.7270/Q2542MKC 3941405 Thompson, SA; Andrews, PR; Hanzlik, RP TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026018&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 44268431 103935760 CHEMBL13279 ZINC40465089 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50029923 COC(=O)\C=C\C(Cc1ccccc1)NC(=O)CN InChI=1S/C14H18N2O3/c1-19-14(18)8-7-12(16-13(17)10-15)9-11-5-3-2-4-6-11/h2-8,12H,9-10,15H2,1H3,(H,16,17)/b8-7+ QEZLQZCMLILKQA-BQYQJAHWSA-N 50026015 4-(2-Amino-acetylamino)-5-phenyl-pent-2-enoic acid methyl ester::CHEMBL13352 Dipeptidyl peptidase 1 220000 ChEMBL 10.1021/jm00151a018 10.7270/Q2542MKC 3941405 Thompson, SA; Andrews, PR; Hanzlik, RP TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026015 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026015&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 44268436 103935757 CHEMBL13352 ZINC40465180 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50029924 NCC(=O)N[C@@H](Cc1ccccc1)C(N)=O InChI=1S/C11H15N3O2/c12-7-10(15)14-9(11(13)16)6-8-4-2-1-3-5-8/h1-5,9H,6-7,12H2,(H2,13,16)(H,14,15)/t9-/m0/s1 PSPZOKPNYCSKSW-VIFPVBQESA-N 50026027 2-(2-Amino-acetylamino)-3-phenyl-propionamide::CHEMBL378267::Gly-Phe-NH2 Dipeptidyl peptidase 1 6200000 ChEMBL 10.1021/jm00151a018 10.7270/Q2542MKC 3941405 Thompson, SA; Andrews, PR; Hanzlik, RP TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026027&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 6993099 103935768 CHEMBL378267 ZINC01605336 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50029926 NCC(=O)NC(Cc1ccccc1)C#N InChI=1S/C11H13N3O/c12-7-10(14-11(15)8-13)6-9-4-2-1-3-5-9/h1-5,10H,6,8,13H2,(H,14,15) QLVGHFBUSGYCCG-UHFFFAOYSA-N 50026017 2-Amino-N-(benzyl-cyano-methyl)-acetamide::CHEMBL12954 Dipeptidyl peptidase 1 2700 ChEMBL 10.1021/jm00151a018 10.7270/Q2542MKC 3941405 Thompson, SA; Andrews, PR; Hanzlik, RP TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026017&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 11241135 103935759 CHEMBL12954 ZINC36338742 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1286499 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)[C@@H]1CNCCCO1 InChI=1S/C22H22N4O2/c23-13-17-4-8-19(9-5-17)18-6-2-16(3-7-18)12-20(14-24)26-22(27)21-15-25-10-1-11-28-21/h2-9,20-21,25H,1,10-12,15H2,(H,26,27)/t20-,21-/m0/s1 FCRODBUNBQJNPU-SFTDATJTSA-N 50195236 CHEMBL3927609::US10287258, Example 1::US10669245, Example 1::US11117874, Example 1::US11673871, Example 34::US11680049, Example 1 Dipeptidyl peptidase 1 35.5 US Patent 10.7270/Q2F76HN2 US11680049 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195236&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253857 375977091 CHEMBL3927609 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1286500 Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H24N4O4/c1-27-19-12-17(7-8-20(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)21-14-25-9-2-10-30-21/h3-8,12,18,21,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,21-/m0/s1 AEXFXNFMSAAELR-RXVVDRJESA-N 50195235 CHEMBL3900409::US10287258, Example 2::US10669245, Example 2::US11117874, Example 2::US11655221, Example 2::US11680049, Example 2 Dipeptidyl peptidase 1 4.47 US Patent 10.7270/Q2F76HN2 US11680049 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195235&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253852 375977090 CHEMBL3900409 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1286501 Cc1cc(cc2n(C)c(=O)oc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H26N4O4/c1-15-10-18(12-20-22(15)32-24(30)28(20)2)17-6-4-16(5-7-17)11-19(13-25)27-23(29)21-14-26-8-3-9-31-21/h4-7,10,12,19,21,26H,3,8-9,11,14H2,1-2H3,(H,27,29)/t19-,21-/m0/s1 WCWJGAFMGPMBQG-FPOVZHCZSA-N 50195240 CHEMBL3960432::US10287258, Example 3::US10669245, Example 3::US11117874, Example 3::US11655221, Example 3::US11680049, Example 3 Dipeptidyl peptidase 1 10.2 US Patent 10.7270/Q2F76HN2 US11680049 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195240&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253824 375977095 CHEMBL3960432 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1286502 CS(=O)(=O)Oc1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C22H25N3O5S/c1-31(27,28)30-20-5-2-4-18(13-20)17-8-6-16(7-9-17)12-19(14-23)25-22(26)21-15-24-10-3-11-29-21/h2,4-9,13,19,21,24H,3,10-12,15H2,1H3,(H,25,26)/t19-,21-/m0/s1 IRYUDRJLDSHZAO-FPOVZHCZSA-N 385044 4′-[(2S)-2-Cyano-2-{[(2S)-1,4-oxazepan-2-ylcarbonyl]amino}ethyl]biphenyl-3-yl methanesulfonate::US10287258, Example 4::US10669245, Example 4::US11117874, Example 4::US11667615, Example 4::US11680049, Example 4 Dipeptidyl peptidase 1 79.4 US Patent 10.7270/Q2F76HN2 US11680049 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385044&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253891 404854267 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1286503 Cc1noc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H24N4O3/c1-15-20-12-18(7-8-21(20)30-27-15)17-5-3-16(4-6-17)11-19(13-24)26-23(28)22-14-25-9-2-10-29-22/h3-8,12,19,22,25H,2,9-11,14H2,1H3,(H,26,28)/t19-,22-/m0/s1 QCTYSVBOKIUUFU-UGKGYDQZSA-N 50195245 CHEMBL3972158::US10287258, Example 5::US10669245, Example 5::US11117874, Example 5::US11655221, Example 5::US11680049, Example 5 Dipeptidyl peptidase 1 16.2 US Patent 10.7270/Q2F76HN2 US11680049 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195245 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195245&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253855 375977100 CHEMBL3972158 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1286507 CN1C(=O)CSc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H26N4O3S/c1-28-20-12-18(7-8-22(20)32-15-23(28)29)17-5-3-16(4-6-17)11-19(13-25)27-24(30)21-14-26-9-2-10-31-21/h3-8,12,19,21,26H,2,9-11,14-15H2,1H3,(H,27,30)/t19-,21-/m0/s1 NSLGCWMFHWURGT-FPOVZHCZSA-N 385049 (2S)-N-{(1S)-1-Cyano-2-[4-(4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzothiazin-6- yl)phenyl]ethyl}-1,4-oxazepane-2-carboxamide::US10287258, Example 9::US10669245, Example 9::US11117874, Example 9::US11655221, Example 9::US11667615, Example 9::US11680049, Example 9 Dipeptidyl peptidase 1 12.9 US Patent 10.7270/Q2F76HN2 US11680049 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385049&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253849 404854272 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1286508 CCn1c2cc(cc(C)c2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C25H28N4O4/c1-3-29-21-13-19(11-16(2)23(21)33-25(29)31)18-7-5-17(6-8-18)12-20(14-26)28-24(30)22-15-27-9-4-10-32-22/h5-8,11,13,20,22,27H,3-4,9-10,12,15H2,1-2H3,(H,28,30)/t20-,22-/m0/s1 ORHUZDNZRYZSJO-UNMCSNQZSA-N 385050 (2S)-N-{(1S)-1-Cyano-2-[4-(3-ethyl-7-methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-5- yl)phenyl]ethyl}-1,4-oxazepane-2-carboxamide::US10287258, Example 10::US10669245, Example 10::US11117874, Example 10::US11655221, Example 10::US11680049, Example 10 Dipeptidyl peptidase 1 21.4 US Patent 10.7270/Q2F76HN2 US11680049 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385050&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253835 404854273 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1286509 CC(C)(O)Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C26H30N4O5/c1-26(2,33)16-30-21-13-19(8-9-22(21)35-25(30)32)18-6-4-17(5-7-18)12-20(14-27)29-24(31)23-15-28-10-3-11-34-23/h4-9,13,20,23,28,33H,3,10-12,15-16H2,1-2H3,(H,29,31)/t20-,23-/m0/s1 LRDOUIXCGZNESR-REWPJTCUSA-N 385051 (2S)-N-[(1S)-1-Cyano-2-{4-[3-(2-hydroxy-2-methylpropyl)-2-oxo-2,3-dihydro-1,3- benzoxazol-5-yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 11::US10669245, Example 11::US11117874, Example 11::US11655221, Example 11::US11667615, Example 11::US11680049, Example 11 Dipeptidyl peptidase 1 89.1 US Patent 10.7270/Q2F76HN2 US11680049 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385051&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253819 404854274 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1286510 FC(F)Cn1c2cc(cc(F)c2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H23F3N4O4/c25-18-9-16(10-19-22(18)35-24(33)31(19)13-21(26)27)15-4-2-14(3-5-15)8-17(11-28)30-23(32)20-12-29-6-1-7-34-20/h2-5,9-10,17,20-21,29H,1,6-8,12-13H2,(H,30,32)/t17-,20-/m0/s1 PVRGXPYTNXSTMU-PXNSSMCTSA-N 385052 (2S)-N-[(1S)-1-Cyano-2-{4-[3-(2,2-difluoroethyl)-7-fluoro-2-oxo-2,3-dihydro-1,3- benzoxazol-5-yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 12::US10669245, Example 12::US11117874, Example 12::US11655221, Example 12::US11667615, Example 12::US11680049, Example 12 Dipeptidyl peptidase 1 10.0 US Patent 10.7270/Q2F76HN2 US11680049 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385052&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253812 404854275 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1286511 CN(C)CCn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C26H31N5O4/c1-30(2)11-12-31-22-15-20(8-9-23(22)35-26(31)33)19-6-4-18(5-7-19)14-21(16-27)29-25(32)24-17-28-10-3-13-34-24/h4-9,15,21,24,28H,3,10-14,17H2,1-2H3,(H,29,32)/t21-,24-/m0/s1 BVHRFMZXVRJZAF-URXFXBBRSA-N 385053 (2S)-N-[(1S)-1-Cyano-2-(4-{3-[2-(dimethylamino)ethyl]-2-oxo-2,3-dihydro-1,3- benzoxazol-5-yl}pheny)ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 13::US10669245, Example 13::US11117874, Example 13::US11655221, Example 13::US11667615, Example 13::US11680049, Example 13 Dipeptidyl peptidase 1 7.24 US Patent 10.7270/Q2F76HN2 US11680049 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385053&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253865 404854276 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1286512 CN1C(=O)C(F)(F)c2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H24F2N4O3/c1-30-20-12-17(7-8-19(20)24(25,26)23(30)32)16-5-3-15(4-6-16)11-18(13-27)29-22(31)21-14-28-9-2-10-33-21/h3-8,12,18,21,28H,2,9-11,14H2,1H3,(H,29,31)/t18-,21-/m0/s1 SABYNPLHFAPZQF-RXVVDRJESA-N 50195242 CHEMBL3917575::US10287258, Example 14::US10669245, Example 14::US11117874, Example 14::US11655221, Example 14::US11680049, Example 14 Dipeptidyl peptidase 1 16.6 US Patent 10.7270/Q2F76HN2 US11680049 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195242&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253811 375977097 CHEMBL3917575 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1286513 Cn1c2cc(cc(F)c2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H23FN4O4/c1-28-19-11-16(10-18(24)21(19)32-23(28)30)15-5-3-14(4-6-15)9-17(12-25)27-22(29)20-13-26-7-2-8-31-20/h3-6,10-11,17,20,26H,2,7-9,13H2,1H3,(H,27,29)/t17-,20-/m0/s1 IVHOZTBKWBUDMJ-PXNSSMCTSA-N 385055 (2S)-N-{(1S)-1-Cyano-2-[4-(7-fluoro-3-methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-5- yl)phenyl]ethyl}-1,4-oxazepane-2-carboxamide::US10287258, Example 15::US10669245, Example 15::US11117874, Example 15::US11655221, Example 15::US11667615, Example 15::US11680049, Example 15 Dipeptidyl peptidase 1 5.13 US Patent 10.7270/Q2F76HN2 US11680049 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385055&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253861 404854278 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1286514 CCn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H26N4O4/c1-2-28-20-13-18(8-9-21(20)32-24(28)30)17-6-4-16(5-7-17)12-19(14-25)27-23(29)22-15-26-10-3-11-31-22/h4-9,13,19,22,26H,2-3,10-12,15H2,1H3,(H,27,29)/t19-,22-/m0/s1 HZZYFVOLMKQYKP-UGKGYDQZSA-N 604854 (2S)-N-{(1S)-1-Cyano-2-[4-(3-ethyl-7-methyl-2-oxo-2,3-dihydro-1,3-benzoxazo1-5-yl)phenyl]ethyl}-1,4-oxazepane-2-carboxamide::US11667615, Example 10::US11667615, Example 16::US11680049, Example 16 Dipeptidyl peptidase 1 5.75 US Patent 10.7270/Q2F76HN2 US11680049 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=604854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=604854&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253883 482597541 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1286515 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2oc(=O)n(CC3CC3)c2c1)C#N)[C@@H]1CNCCCO1 InChI=1S/C26H28N4O4/c27-14-21(29-25(31)24-15-28-10-1-11-33-24)12-17-4-6-19(7-5-17)20-8-9-23-22(13-20)30(26(32)34-23)16-18-2-3-18/h4-9,13,18,21,24,28H,1-3,10-12,15-16H2,(H,29,31)/t21-,24-/m0/s1 WJXGZWWSCFPECN-URXFXBBRSA-N 385057 (2S)-N-[(1S)-1-Cyano-2-{4-[3-(cyclopropylmethyl)-2-oxo-2,3-dihydro-1,3-benzoxazol- 5-yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 17::US10669245, Example 17::US11117874, Example 17::US11655221, Example 17::US11667615, Example 17::US11680049, Example 17 Dipeptidyl peptidase 1 6.31 US Patent 10.7270/Q2F76HN2 US11680049 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385057&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253827 404854280 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1286504 FC(F)(F)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C22H22F3N3O2/c23-22(24,25)18-8-6-17(7-9-18)16-4-2-15(3-5-16)12-19(13-26)28-21(29)20-14-27-10-1-11-30-20/h2-9,19-20,27H,1,10-12,14H2,(H,28,29)/t19-,20-/m0/s1 USBDHHJQNTYSNJ-PMACEKPBSA-N 50195255 CHEMBL3945475::US10287258, Example 6::US10669245, Example 6::US11117874, Example 6::US11655221, Example 6::US11680049, Example 6 Dipeptidyl peptidase 1 36.3 US Patent 10.7270/Q2F76HN2 US11680049 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195255 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195255&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253859 375977110 CHEMBL3945475 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1286505 Fc1ccc(cc1F)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C21H21F2N3O2/c22-18-7-6-16(11-19(18)23)15-4-2-14(3-5-15)10-17(12-24)26-21(27)20-13-25-8-1-9-28-20/h2-7,11,17,20,25H,1,8-10,13H2,(H,26,27)/t17-,20-/m0/s1 HSWVIXGRFREZJG-PXNSSMCTSA-N 385047 (2S)-N-[(1S)-1-Cyano-2-(3',4'-difluorobiphenyl-4-yl)ethyl]-1,4-oxazepane-2- carboxamide::US10287258, Example 7::US10669245, Example 7::US11117874, Example 7::US11655221, Example 7::US11667615, Example 7::US11680049, Example 7 Dipeptidyl peptidase 1 69.2 US Patent 10.7270/Q2F76HN2 US11680049 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385047&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253829 404854270 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1286506 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(nc1)C#N)C#N)[C@@H]1CNCCCO1 InChI=1S/C21H21N5O2/c22-11-18-7-6-17(13-25-18)16-4-2-15(3-5-16)10-19(12-23)26-21(27)20-14-24-8-1-9-28-20/h2-7,13,19-20,24H,1,8-10,14H2,(H,26,27)/t19-,20-/m0/s1 UZXVZQQAOVNOKG-PMACEKPBSA-N 385048 (2S)-N-{(1S)-1-Cyano-2-[4-(6-cyanopyridin-3-yl)phenyl]ethyl}-1,4-oxazepane-2- carboxamide::US10287258, Example 8::US10669245, Example 8::US11117874, Example 8::US11655221, Example 8::US11667615, Example 8::US11680049, Example 8 Dipeptidyl peptidase 1 87.1 US Patent 10.7270/Q2F76HN2 US11680049 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385048&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253853 404854271 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1286516 COCCn1c2cc(ccc2sc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C25H28N4O4S/c1-32-12-10-29-21-14-19(7-8-23(21)34-25(29)31)18-5-3-17(4-6-18)13-20(15-26)28-24(30)22-16-27-9-2-11-33-22/h3-8,14,20,22,27H,2,9-13,16H2,1H3,(H,28,30)/t20-,22-/m0/s1 GRJJVLYWMJAVMA-UNMCSNQZSA-N 385058 (2S)-N-[(1S)-1-Cyano-2-{4-[3-(2-methoxyethyl)-2-oxo-2,3-dihydro-1,3-benzothiazol- 5-yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 18::US10669245, Example 18::US11117874, Example 18::US11655221, Example 18::US11667615, Example 18::US11680049, Example 18 Dipeptidyl peptidase 1 3.16 US Patent 10.7270/Q2F76HN2 US11680049 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385058&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253842 404854281 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1286517 CC(C)n1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C25H28N4O4/c1-16(2)29-21-13-19(8-9-22(21)33-25(29)31)18-6-4-17(5-7-18)12-20(14-26)28-24(30)23-15-27-10-3-11-32-23/h4-9,13,16,20,23,27H,3,10-12,15H2,1-2H3,(H,28,30)/t20-,23-/m0/s1 WOBKXJRTDASPHQ-REWPJTCUSA-N 385059 (2S)-N- [(1S)-1-Cyano-2-{4-[2-oxo-3-(propan-2-yl)-2,3-dihydro-1,3-benzoxazol-5- yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 19::US10669245, Example 19::US11117874, Example 19::US11655221, Example 19::US11667615, Example 19::US11680049, Example 19 Dipeptidyl peptidase 1 14.5 US Patent 10.7270/Q2F76HN2 US11680049 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385059&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253878 404854282 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1286518 CN1C(=O)COc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H26N4O4/c1-28-20-12-18(7-8-21(20)32-15-23(28)29)17-5-3-16(4-6-17)11-19(13-25)27-24(30)22-14-26-9-2-10-31-22/h3-8,12,19,22,26H,2,9-11,14-15H2,1H3,(H,27,30)/t19-,22-/m0/s1 QKDQSHLZLZUQOA-UGKGYDQZSA-N 50195238 CHEMBL3962926::US10287258, Example 20::US10669245, Example 20::US11117874, Example 20::US11655221, Example 20::US11680049, Example 20 Dipeptidyl peptidase 1 12.6 US Patent 10.7270/Q2F76HN2 US11680049 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195238 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195238&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253870 375977093 CHEMBL3962926 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1286519 COCCn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C25H28N4O5/c1-32-12-10-29-21-14-19(7-8-22(21)34-25(29)31)18-5-3-17(4-6-18)13-20(15-26)28-24(30)23-16-27-9-2-11-33-23/h3-8,14,20,23,27H,2,9-13,16H2,1H3,(H,28,30)/t20-,23-/m0/s1 JUXOTDAODWSCQS-REWPJTCUSA-N 385061 (2S)-N-[(1S)-1-Cyano-2-{4-[3-(2-methoxyethyl)-2-oxo-2,3-dihydro-1,3-benzoxazol-5- yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 21::US10669245, Example 21::US11117874, Example 21::US11655221, Example 21::US11667615, Example 21::US11680049, Example 21 Dipeptidyl peptidase 1 8.13 US Patent 10.7270/Q2F76HN2 US11680049 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385061&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253879 404854284 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1286524 Cn1c2cc(cc(Cl)c2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H23ClN4O4/c1-28-19-11-16(10-18(24)21(19)32-23(28)30)15-5-3-14(4-6-15)9-17(12-25)27-22(29)20-13-26-7-2-8-31-20/h3-6,10-11,17,20,26H,2,7-9,13H2,1H3,(H,27,29)/t17-,20-/m0/s1 KTGYWWMCWUTXTI-PXNSSMCTSA-N 385066 (2S)-N-{(1S)-2-[4-(7-Chloro-3-methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)phenyl]- 1-cyanoethyl}-1,4-oxazepane-2-carboxamide::US10287258, Example 26::US10669245, Example 26::US11117874, Example 26::US11655221, Example 26::US11667615, Example 26::US11680049, Example 26 Dipeptidyl peptidase 1 13.5 US Patent 10.7270/Q2F76HN2 US11680049 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385066&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253874 404854289 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1286525 FC(F)Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H24F2N4O4/c25-22(26)14-30-19-11-17(6-7-20(19)34-24(30)32)16-4-2-15(3-5-16)10-18(12-27)29-23(31)21-13-28-8-1-9-33-21/h2-7,11,18,21-22,28H,1,8-10,13-14H2,(H,29,31)/t18-,21-/m0/s1 ANPJTTUBCRFBKA-RXVVDRJESA-N 50195248 CHEMBL3891374::US10287258, Example 27::US10669245, Example 27::US11117874, Example 27::US11655221, Example 27::US11680049, Example 27 Dipeptidyl peptidase 1 6.61 US Patent 10.7270/Q2F76HN2 US11680049 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195248 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195248&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253888 375977103 CHEMBL3891374 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1286526 FC(F)(F)Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H23F3N4O4/c25-24(26,27)14-31-19-11-17(6-7-20(19)35-23(31)33)16-4-2-15(3-5-16)10-18(12-28)30-22(32)21-13-29-8-1-9-34-21/h2-7,11,18,21,29H,1,8-10,13-14H2,(H,30,32)/t18-,21-/m0/s1 KAGSLWGZQVTFPB-RXVVDRJESA-N 385068 (2S)-N-[(1S)-1-Cyano-2-{4-[2-oxo-3-(2,2,2-trifluoroethyl)-2,3-dihydro-1,3- benzoxazol-5-yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 28::US10669245, Example 28::US11117874, Example 28::US11655221, Example 28::US11667615, Example 28::US11680049, Example 28 Dipeptidyl peptidase 1 8.13 US Patent 10.7270/Q2F76HN2 US11680049 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385068&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253867 404854291 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1286527 Cn1c2cc(ccc2sc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H24N4O3S/c1-27-19-12-17(7-8-21(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)20-14-25-9-2-10-30-20/h3-8,12,18,20,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,20-/m0/s1 DRQDONWWFWYTII-ICSRJNTNSA-N 50195239 CHEMBL3972563::US10287258, Example 29::US10669245, Example 29::US11117874, Example 29::US11655221, Example 29::US11680049, Example 29 Dipeptidyl peptidase 1 2.40 US Patent 10.7270/Q2F76HN2 US11680049 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195239&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91826235 375977094 CHEMBL3972563 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1286528 CS(=O)(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C22H25N3O4S/c1-30(27,28)20-9-7-18(8-10-20)17-5-3-16(4-6-17)13-19(14-23)25-22(26)21-15-24-11-2-12-29-21/h3-10,19,21,24H,2,11-13,15H2,1H3,(H,25,26)/t19-,21-/m0/s1 UBRDXNDHEGQOTI-FPOVZHCZSA-N 385070 (2S)-N-{(1S)-1-Cyano-2-[4'-(methylsulfonyl)bipheny1-4-yl]ethyl}-1,4-oxazepane-2- carboxamide::US10287258, Example 30::US10669245, Example 30::US11117874, Example 30::US11655221, Example 30::US11667615, Example 30::US11680049, Example 30 Dipeptidyl peptidase 1 37.2 US Patent 10.7270/Q2F76HN2 US11680049 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385070&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253895 404854293 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1286529 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N1CCC1)C#N)[C@@H]1CNCCCO1 InChI=1S/C24H28N4O4S/c25-16-21(27-24(29)23-17-26-11-1-14-32-23)15-18-3-5-19(6-4-18)20-7-9-22(10-8-20)33(30,31)28-12-2-13-28/h3-10,21,23,26H,1-2,11-15,17H2,(H,27,29)/t21-,23-/m0/s1 CBWWXOUBSQCMHB-GMAHTHKFSA-N 385071 (2S)-N-{(1S)-2-[4'-(Azetidin-1-ylsulfonyl)biphenyl-4-yl]-1-cyanoethyl}-1,4-oxazepane- 2-carboxamide::US10287258, Example 31::US10669245, Example 31::US11117874, Example 31::US11655221, Example 31::US11667615, Example 31::US11680049, Example 31 Dipeptidyl peptidase 1 21.4 US Patent 10.7270/Q2F76HN2 US11680049 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385071&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253890 404854294 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1286530 Fc1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C21H22FN3O2/c22-18-8-6-17(7-9-18)16-4-2-15(3-5-16)12-19(13-23)25-21(26)20-14-24-10-1-11-27-20/h2-9,19-20,24H,1,10-12,14H2,(H,25,26)/t19-,20-/m0/s1 PYXGGJVWIVBQRO-PMACEKPBSA-N 385072 (2S)-N-[(1S)-1-Cyano-2-(4'-fluorobiphenyl-4-yl)ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 32::US10669245, Example 32::US11117874, Example 32::US11655221, Example 32::US11667615, Example 32::US11680049, Example 32 Dipeptidyl peptidase 1 42.7 US Patent 10.7270/Q2F76HN2 US11680049 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385072&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253858 404854295 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1286531 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2scnc2c1)C#N)[C@@H]1CNCCCO1 InChI=1S/C22H22N4O2S/c23-12-18(26-22(27)20-13-24-8-1-9-28-20)10-15-2-4-16(5-3-15)17-6-7-21-19(11-17)25-14-29-21/h2-7,11,14,18,20,24H,1,8-10,13H2,(H,26,27)/t18-,20-/m0/s1 MUTKXUKCDAFWLB-ICSRJNTNSA-N 50195263 CHEMBL3942969::US10287258, Example 33::US10669245, Example 33::US11117874, Example 33::US11673871, Example 33::US11680049, Example 33 Dipeptidyl peptidase 1 61.7 US Patent 10.7270/Q2F76HN2 US11680049 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195263&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253877 375977118 CHEMBL3942969 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1286532 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)C1CNCCCO1 InChI=1S/C22H22N4O2/c23-13-17-4-8-19(9-5-17)18-6-2-16(3-7-18)12-20(14-24)26-22(27)21-15-25-10-1-11-28-21/h2-9,20-21,25H,1,10-12,15H2,(H,26,27)/t20-,21?/m0/s1 FCRODBUNBQJNPU-BGERDNNASA-N 385074 US10287258, Example 34::US10669245, Example 34::US11117874, Example 34::US11667615, Example 34::US11680049, Example 34 Dipeptidyl peptidase 1 60.3 US Patent 10.7270/Q2F76HN2 US11680049 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385074&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118260121 404854297 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1286533 CN1C(=O)CNc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H27N5O3/c1-29-21-12-18(7-8-20(21)27-15-23(29)30)17-5-3-16(4-6-17)11-19(13-25)28-24(31)22-14-26-9-2-10-32-22/h3-8,12,19,22,26-27H,2,9-11,14-15H2,1H3,(H,28,31)/t19-,22-/m0/s1 CPBDCTBYFQTDMV-UGKGYDQZSA-N 385075 US10287258, Example 35::US10669245, Example 35::US11117874, Example 35::US11673871, Example 35::US11680049, Example 35 Dipeptidyl peptidase 1 24.5 US Patent 10.7270/Q2F76HN2 US11680049 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385075&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253822 404854298 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1286534 CC[C@H](NC(=O)[C@@H]1CNCCCO1)\C=C\C(=O)N1CCc2ccccc12 InChI=1S/C20H27N3O3/c1-2-16(22-20(25)18-14-21-11-5-13-26-18)8-9-19(24)23-12-10-15-6-3-4-7-17(15)23/h3-4,6-9,16,18,21H,2,5,10-14H2,1H3,(H,22,25)/b9-8+/t16-,18-/m0/s1 OHNHQTNQBQMALV-LFGVRAQPSA-N 385076 BDBM445984::US10287258, Example 36::US11667615, Example 36::US11680049, Example 36 Dipeptidyl peptidase 1 5.01 US Patent 10.7270/Q2F76HN2 US11680049 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385076&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 144891673 404854299 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1286535 CC(C)C[C@H](NC(=O)[C@@H]1CNCCCO1)\C=C\C(=O)N1CCc2ccccc12 InChI=1S/C22H31N3O3/c1-16(2)14-18(24-22(27)20-15-23-11-5-13-28-20)8-9-21(26)25-12-10-17-6-3-4-7-19(17)25/h3-4,6-9,16,18,20,23H,5,10-15H2,1-2H3,(H,24,27)/b9-8+/t18-,20+/m1/s1 PXFMGAFAIVURSO-ZZHWGSSASA-N 385077 BDBM445985::US10287258, Example 37::US11667615, Example 37::US11680049, Example 37 Dipeptidyl peptidase 1 5.25 US Patent 10.7270/Q2F76HN2 US11680049 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385077&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 144891689 404854300 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1286520 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(s1)C#N)C#N)[C@@H]1CNCCCO1 InChI=1S/C20H20N4O2S/c21-11-16(24-20(25)18-13-23-8-1-9-26-18)10-14-2-4-15(5-3-14)19-7-6-17(12-22)27-19/h2-7,16,18,23H,1,8-10,13H2,(H,24,25)/t16-,18-/m0/s1 AYKAKRZDQIFHMD-WMZOPIPTSA-N 385062 (2S)-N-{(1S)-1-Cyano-2-[4-(5-cyanothiophen-2-yl)phenyl]ethyl}-1,4-oxazepane-2- carboxamide::US10287258, Example 22::US10669245, Example 22::US11117874, Example 22::US11655221, Example 22::US11667615, Example 22::US11680049, Example 22 Dipeptidyl peptidase 1 19.5 US Patent 10.7270/Q2F76HN2 US11680049 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385062&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253837 404854285 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1286521 NC(=O)c1ccc(cc1F)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C22H23FN4O3/c23-19-11-16(6-7-18(19)21(25)28)15-4-2-14(3-5-15)10-17(12-24)27-22(29)20-13-26-8-1-9-30-20/h2-7,11,17,20,26H,1,8-10,13H2,(H2,25,28)(H,27,29)/t17-,20-/m0/s1 GCGGEFOSHQPZEX-PXNSSMCTSA-N 385063 (2S)-N-[(1S)-2-(4'-Carbamoy1-3'-fluorobiphenyl-4-yl)-1-cyanoethyl]-1,4-oxazepane-2- carboxamide::US10287258, Example 23::US10669245, Example 23::US11117874, Example 23::US11655221, Example 23::US11667615, Example 23::US11680049, Example 23 Dipeptidyl peptidase 1 67.6 US Patent 10.7270/Q2F76HN2 US11680049 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385063&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253894 404854286 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1286522 Cn1c2cc(ccc2ccc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C25H26N4O3/c1-29-22-14-20(8-7-19(22)9-10-24(29)30)18-5-3-17(4-6-18)13-21(15-26)28-25(31)23-16-27-11-2-12-32-23/h3-10,14,21,23,27H,2,11-13,16H2,1H3,(H,28,31)/t21-,23-/m0/s1 BQIZWZAQEICNDG-GMAHTHKFSA-N 50195244 CHEMBL3926554::US10287258, Example 24::US10669245, Example 24::US11117874, Example 24::US11655221, Example 24::US11680049, Example 24 Dipeptidyl peptidase 1 13.8 US Patent 10.7270/Q2F76HN2 US11680049 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195244&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253851 375977099 CHEMBL3926554 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1286523 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2oc(=O)n(CC3CCOCC3)c2c1)C#N)[C@@H]1CNCCCO1 InChI=1S/C28H32N4O5/c29-16-23(31-27(33)26-17-30-10-1-11-36-26)14-19-2-4-21(5-3-19)22-6-7-25-24(15-22)32(28(34)37-25)18-20-8-12-35-13-9-20/h2-7,15,20,23,26,30H,1,8-14,17-18H2,(H,31,33)/t23-,26-/m0/s1 KFOHIWSKADTAQW-OZXSUGGESA-N 385065 (2S)-N-[(1S)-1-Cyano-2-{4-[2-oxo-3-(tetrahydro-2H-pyran-4-ylmethyl)-2,3-dihydro- 1,3-benzoxazol-5-yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 25::US10669245, Example 25::US11117874, Example 25::US11655221, Example 25::US11667615, Example 25::US11680049, Example 25 Dipeptidyl peptidase 1 10.7 US Patent 10.7270/Q2F76HN2 US11680049 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385065&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253876 404854288 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50091510 NC1(CCCCC1)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N InChI=1S/C23H24N4O/c24-15-18-6-10-20(11-7-18)19-8-4-17(5-9-19)14-21(16-25)27-22(28)23(26)12-2-1-3-13-23/h4-11,21H,1-3,12-14,26H2,(H,27,28)/t21-/m0/s1 MGOYHCLHZFUGJC-NRFANRHFSA-N 50011500 CHEMBL3261924 Dipeptidyl peptidase 1 3.2 ChEMBL 10.1021/jm401705g 10.7270/Q20866VB 24592859 Furber, M; Tiden, AK; Gardiner, P; Mete, A; Ford, R; Millichip, I; Stein, L; Mather, A; Kinchin, E; Luckhurst, C; Barber, S; Cage, P; Sanganee, H; Austin, R; Chohan, K; Beri, R; Thong, B; Wallace, A; Oreffo, V; Hutchinson, R; Harper, S; Debreczeni, J; Breed, J; Wissler, L; Edman, K AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50011500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50011500&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 54769914 103924053 CHEMBL3261924 ZINC36272107 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50091511 NC1(CCOCC1)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccccc1)C#N InChI=1S/C21H23N3O2/c22-15-19(24-20(25)21(23)10-12-26-13-11-21)14-16-6-8-18(9-7-16)17-4-2-1-3-5-17/h1-9,19H,10-14,23H2,(H,24,25)/t19-/m0/s1 YEOQUBBPBNJOAA-IBGZPJMESA-N 50011501 CHEMBL3261925 Dipeptidyl peptidase 1 32 ChEMBL 10.1021/jm401705g 10.7270/Q20866VB 24592859 Furber, M; Tiden, AK; Gardiner, P; Mete, A; Ford, R; Millichip, I; Stein, L; Mather, A; Kinchin, E; Luckhurst, C; Barber, S; Cage, P; Sanganee, H; Austin, R; Chohan, K; Beri, R; Thong, B; Wallace, A; Oreffo, V; Hutchinson, R; Harper, S; Debreczeni, J; Breed, J; Wissler, L; Edman, K AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50011501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50011501&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 66645269 103924054 CHEMBL3261925 ZINC36271893 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50091512 NC1(CCOCC1)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N InChI=1S/C22H22N4O2/c23-14-17-3-7-19(8-4-17)18-5-1-16(2-6-18)13-20(15-24)26-21(27)22(25)9-11-28-12-10-22/h1-8,20H,9-13,25H2,(H,26,27)/t20-/m0/s1 NNUFRZJZOXVZIT-FQEVSTJZSA-N 50011502 CHEMBL3261926 Dipeptidyl peptidase 1 5.0 ChEMBL 10.1021/jm401705g 10.7270/Q20866VB 24592859 Furber, M; Tiden, AK; Gardiner, P; Mete, A; Ford, R; Millichip, I; Stein, L; Mather, A; Kinchin, E; Luckhurst, C; Barber, S; Cage, P; Sanganee, H; Austin, R; Chohan, K; Beri, R; Thong, B; Wallace, A; Oreffo, V; Hutchinson, R; Harper, S; Debreczeni, J; Breed, J; Wissler, L; Edman, K AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50011502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50011502&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 49783666 103924055 CHEMBL3261926 ZINC36271864 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50091513 CS(=O)(=O)c1cccc(c1)-c1ccc(C[C@H](NC(=O)C2(N)CCOCC2)C#N)cc1 InChI=1S/C22H25N3O4S/c1-30(27,28)20-4-2-3-18(14-20)17-7-5-16(6-8-17)13-19(15-23)25-21(26)22(24)9-11-29-12-10-22/h2-8,14,19H,9-13,24H2,1H3,(H,25,26)/t19-/m0/s1 VUCFAFRVHRIURK-IBGZPJMESA-N 50011503 CHEMBL3261927 Dipeptidyl peptidase 1 7.9 ChEMBL 10.1021/jm401705g 10.7270/Q20866VB 24592859 Furber, M; Tiden, AK; Gardiner, P; Mete, A; Ford, R; Millichip, I; Stein, L; Mather, A; Kinchin, E; Luckhurst, C; Barber, S; Cage, P; Sanganee, H; Austin, R; Chohan, K; Beri, R; Thong, B; Wallace, A; Oreffo, V; Hutchinson, R; Harper, S; Debreczeni, J; Breed, J; Wissler, L; Edman, K AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50011503 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50011503&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 49783903 103924056 CHEMBL3261927 ZINC36271851 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50091514 CN1Cc2ccc(cc2C1=O)-c1ccc(C[C@H](NC(=O)C2(N)CCOCC2)C#N)cc1 InChI=1S/C24H26N4O3/c1-28-15-19-7-6-18(13-21(19)22(28)29)17-4-2-16(3-5-17)12-20(14-25)27-23(30)24(26)8-10-31-11-9-24/h2-7,13,20H,8-12,15,26H2,1H3,(H,27,30)/t20-/m0/s1 ALYPEORYGVOPDI-FQEVSTJZSA-N 50011504 CHEMBL3261928 Dipeptidyl peptidase 1 50 ChEMBL 10.1021/jm401705g 10.7270/Q20866VB 24592859 Furber, M; Tiden, AK; Gardiner, P; Mete, A; Ford, R; Millichip, I; Stein, L; Mather, A; Kinchin, E; Luckhurst, C; Barber, S; Cage, P; Sanganee, H; Austin, R; Chohan, K; Beri, R; Thong, B; Wallace, A; Oreffo, V; Hutchinson, R; Harper, S; Debreczeni, J; Breed, J; Wissler, L; Edman, K AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50011504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50011504&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 49783985 103924057 CHEMBL3261928 ZINC36271991 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50091550 CC[C@H](N)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccccc1)C#N InChI=1S/C19H21N3O/c1-2-18(21)19(23)22-17(13-20)12-14-8-10-16(11-9-14)15-6-4-3-5-7-15/h3-11,17-18H,2,12,21H2,1H3,(H,22,23)/t17-,18-/m0/s1 DPOJEFZKFIWUGN-ROUUACIJSA-N 50186088 (S)-2-amino-N-((S)-2-(biphenyl-4-yl)-1-cyanoethyl)butanamide::(S)-2-amino-N-((S)-2-biphenyl-4-yl-1-cyano-ethyl)-butyramide::CHEMBL212521 Dipeptidyl peptidase 1 2.0 ChEMBL 10.1021/jm401705g 10.7270/Q20866VB 24592859 Furber, M; Tiden, AK; Gardiner, P; Mete, A; Ford, R; Millichip, I; Stein, L; Mather, A; Kinchin, E; Luckhurst, C; Barber, S; Cage, P; Sanganee, H; Austin, R; Chohan, K; Beri, R; Thong, B; Wallace, A; Oreffo, V; Hutchinson, R; Harper, S; Debreczeni, J; Breed, J; Wissler, L; Edman, K AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50186088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50186088&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 11771234 104070152 CHEMBL212521 ZINC36323060 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50091551 O=C(N[C@@H](Cc1ccc(cc1)-c1ccccc1)C#N)[C@@H]1CCCCN1 InChI=1S/C21H23N3O/c22-15-19(24-21(25)20-8-4-5-13-23-20)14-16-9-11-18(12-10-16)17-6-2-1-3-7-17/h1-3,6-7,9-12,19-20,23H,4-5,8,13-14H2,(H,24,25)/t19-,20-/m0/s1 AGQMDQHFBCAQCC-PMACEKPBSA-N 50011510 CHEMBL3261918 Dipeptidyl peptidase 1 126 ChEMBL 10.1021/jm401705g 10.7270/Q20866VB 24592859 Furber, M; Tiden, AK; Gardiner, P; Mete, A; Ford, R; Millichip, I; Stein, L; Mather, A; Kinchin, E; Luckhurst, C; Barber, S; Cage, P; Sanganee, H; Austin, R; Chohan, K; Beri, R; Thong, B; Wallace, A; Oreffo, V; Hutchinson, R; Harper, S; Debreczeni, J; Breed, J; Wissler, L; Edman, K AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50011510 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50011510&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 57999656 103924063 CHEMBL3261918 ZINC36272060 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50091552 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)[C@@H]1CCCCN1 InChI=1S/C22H22N4O/c23-14-17-6-10-19(11-7-17)18-8-4-16(5-9-18)13-20(15-24)26-22(27)21-3-1-2-12-25-21/h4-11,20-21,25H,1-3,12-13H2,(H,26,27)/t20-,21-/m0/s1 NWEHEPXTNMPJSH-SFTDATJTSA-N 50011505 CHEMBL3261919 Dipeptidyl peptidase 1 40 ChEMBL 10.1021/jm401705g 10.7270/Q20866VB 24592859 Furber, M; Tiden, AK; Gardiner, P; Mete, A; Ford, R; Millichip, I; Stein, L; Mather, A; Kinchin, E; Luckhurst, C; Barber, S; Cage, P; Sanganee, H; Austin, R; Chohan, K; Beri, R; Thong, B; Wallace, A; Oreffo, V; Hutchinson, R; Harper, S; Debreczeni, J; Breed, J; Wissler, L; Edman, K AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50011505 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50011505&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 42641892 103924058 CHEMBL3261919 ZINC36271870 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50091553 CSc1cc(ccc1C#N)-c1ccc(C[C@H](NC(=O)[C@@H]2CCCCN2)C#N)cc1 InChI=1S/C23H24N4OS/c1-29-22-13-18(9-10-19(22)14-24)17-7-5-16(6-8-17)12-20(15-25)27-23(28)21-4-2-3-11-26-21/h5-10,13,20-21,26H,2-4,11-12H2,1H3,(H,27,28)/t20-,21-/m0/s1 NMLYRXXREIIYKN-SFTDATJTSA-N 50011506 CHEMBL3261920 Dipeptidyl peptidase 1 4.0 ChEMBL 10.1021/jm401705g 10.7270/Q20866VB 24592859 Furber, M; Tiden, AK; Gardiner, P; Mete, A; Ford, R; Millichip, I; Stein, L; Mather, A; Kinchin, E; Luckhurst, C; Barber, S; Cage, P; Sanganee, H; Austin, R; Chohan, K; Beri, R; Thong, B; Wallace, A; Oreffo, V; Hutchinson, R; Harper, S; Debreczeni, J; Breed, J; Wissler, L; Edman, K AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50011506 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50011506&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 42642459 103924059 CHEMBL3261920 ZINC36271952 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50091554 CN1Cc2cc(ccc2C1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CCCCN2)C#N)cc1 InChI=1S/C24H26N4O2/c1-28-15-19-13-18(9-10-21(19)24(28)30)17-7-5-16(6-8-17)12-20(14-25)27-23(29)22-4-2-3-11-26-22/h5-10,13,20,22,26H,2-4,11-12,15H2,1H3,(H,27,29)/t20-,22-/m0/s1 OWXGOHWYUAIZNU-UNMCSNQZSA-N 50011507 CHEMBL3261921 Dipeptidyl peptidase 1 25 ChEMBL 10.1021/jm401705g 10.7270/Q20866VB 24592859 Furber, M; Tiden, AK; Gardiner, P; Mete, A; Ford, R; Millichip, I; Stein, L; Mather, A; Kinchin, E; Luckhurst, C; Barber, S; Cage, P; Sanganee, H; Austin, R; Chohan, K; Beri, R; Thong, B; Wallace, A; Oreffo, V; Hutchinson, R; Harper, S; Debreczeni, J; Breed, J; Wissler, L; Edman, K AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50011507 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50011507&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90655967 103924060 CHEMBL3261921 ZINC36272054 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50091555 O[C@H]1CCN[C@@H](C1)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N InChI=1S/C22H22N4O2/c23-13-16-3-7-18(8-4-16)17-5-1-15(2-6-17)11-19(14-24)26-22(28)21-12-20(27)9-10-25-21/h1-8,19-21,25,27H,9-12H2,(H,26,28)/t19-,20-,21-/m0/s1 ZBEHEQLBNJJNRN-ACRUOGEOSA-N 50011508 CHEMBL3261922 Dipeptidyl peptidase 1 5.0 ChEMBL 10.1021/jm401705g 10.7270/Q20866VB 24592859 Furber, M; Tiden, AK; Gardiner, P; Mete, A; Ford, R; Millichip, I; Stein, L; Mather, A; Kinchin, E; Luckhurst, C; Barber, S; Cage, P; Sanganee, H; Austin, R; Chohan, K; Beri, R; Thong, B; Wallace, A; Oreffo, V; Hutchinson, R; Harper, S; Debreczeni, J; Breed, J; Wissler, L; Edman, K AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50011508 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50011508&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90655968 103924061 CHEMBL3261922 ZINC36272098 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50091556 CN1Cc2cc(ccc2C1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2C[C@@H](O)CCN2)C#N)cc1 InChI=1S/C24H26N4O3/c1-28-14-18-11-17(6-7-21(18)24(28)31)16-4-2-15(3-5-16)10-19(13-25)27-23(30)22-12-20(29)8-9-26-22/h2-7,11,19-20,22,26,29H,8-10,12,14H2,1H3,(H,27,30)/t19-,20-,22-/m0/s1 XXVWENSFIHCLPM-ONTIZHBOSA-N 50011509 CHEMBL3261923 Dipeptidyl peptidase 1 4.0 ChEMBL 10.1021/jm401705g 10.7270/Q20866VB 24592859 Furber, M; Tiden, AK; Gardiner, P; Mete, A; Ford, R; Millichip, I; Stein, L; Mather, A; Kinchin, E; Luckhurst, C; Barber, S; Cage, P; Sanganee, H; Austin, R; Chohan, K; Beri, R; Thong, B; Wallace, A; Oreffo, V; Hutchinson, R; Harper, S; Debreczeni, J; Breed, J; Wissler, L; Edman, K AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50011509 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50011509&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90655969 103924062 CHEMBL3261923 ZINC36271895 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50091557 NC1(CCCCC1)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N InChI=1S/C23H24N4O/c24-15-18-6-10-20(11-7-18)19-8-4-17(5-9-19)14-21(16-25)27-22(28)23(26)12-2-1-3-13-23/h4-11,21H,1-3,12-14,26H2,(H,27,28)/t21-/m0/s1 MGOYHCLHZFUGJC-NRFANRHFSA-N 50011500 CHEMBL3261924 Dipeptidyl peptidase 1 2.5 ChEMBL 10.1021/jm401705g 10.7270/Q20866VB 24592859 Furber, M; Tiden, AK; Gardiner, P; Mete, A; Ford, R; Millichip, I; Stein, L; Mather, A; Kinchin, E; Luckhurst, C; Barber, S; Cage, P; Sanganee, H; Austin, R; Chohan, K; Beri, R; Thong, B; Wallace, A; Oreffo, V; Hutchinson, R; Harper, S; Debreczeni, J; Breed, J; Wissler, L; Edman, K AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50011500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50011500&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 54769914 103924053 CHEMBL3261924 ZINC36272107 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50091558 NC1(CCOCC1)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccccc1)C#N InChI=1S/C21H23N3O2/c22-15-19(24-20(25)21(23)10-12-26-13-11-21)14-16-6-8-18(9-7-16)17-4-2-1-3-5-17/h1-9,19H,10-14,23H2,(H,24,25)/t19-/m0/s1 YEOQUBBPBNJOAA-IBGZPJMESA-N 50011501 CHEMBL3261925 Dipeptidyl peptidase 1 2.0 ChEMBL 10.1021/jm401705g 10.7270/Q20866VB 24592859 Furber, M; Tiden, AK; Gardiner, P; Mete, A; Ford, R; Millichip, I; Stein, L; Mather, A; Kinchin, E; Luckhurst, C; Barber, S; Cage, P; Sanganee, H; Austin, R; Chohan, K; Beri, R; Thong, B; Wallace, A; Oreffo, V; Hutchinson, R; Harper, S; Debreczeni, J; Breed, J; Wissler, L; Edman, K AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50011501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50011501&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 66645269 103924054 CHEMBL3261925 ZINC36271893 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50091559 NC1(CCOCC1)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N InChI=1S/C22H22N4O2/c23-14-17-3-7-19(8-4-17)18-5-1-16(2-6-18)13-20(15-24)26-21(27)22(25)9-11-28-12-10-22/h1-8,20H,9-13,25H2,(H,26,27)/t20-/m0/s1 NNUFRZJZOXVZIT-FQEVSTJZSA-N 50011502 CHEMBL3261926 Dipeptidyl peptidase 1 1.000000 ChEMBL 10.1021/jm401705g 10.7270/Q20866VB 24592859 Furber, M; Tiden, AK; Gardiner, P; Mete, A; Ford, R; Millichip, I; Stein, L; Mather, A; Kinchin, E; Luckhurst, C; Barber, S; Cage, P; Sanganee, H; Austin, R; Chohan, K; Beri, R; Thong, B; Wallace, A; Oreffo, V; Hutchinson, R; Harper, S; Debreczeni, J; Breed, J; Wissler, L; Edman, K AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50011502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50011502&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 49783666 103924055 CHEMBL3261926 ZINC36271864 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50091560 CS(=O)(=O)c1cccc(c1)-c1ccc(C[C@H](NC(=O)C2(N)CCOCC2)C#N)cc1 InChI=1S/C22H25N3O4S/c1-30(27,28)20-4-2-3-18(14-20)17-7-5-16(6-8-17)13-19(15-23)25-21(26)22(24)9-11-29-12-10-22/h2-8,14,19H,9-13,24H2,1H3,(H,25,26)/t19-/m0/s1 VUCFAFRVHRIURK-IBGZPJMESA-N 50011503 CHEMBL3261927 Dipeptidyl peptidase 1 0.794328 ChEMBL 10.1021/jm401705g 10.7270/Q20866VB 24592859 Furber, M; Tiden, AK; Gardiner, P; Mete, A; Ford, R; Millichip, I; Stein, L; Mather, A; Kinchin, E; Luckhurst, C; Barber, S; Cage, P; Sanganee, H; Austin, R; Chohan, K; Beri, R; Thong, B; Wallace, A; Oreffo, V; Hutchinson, R; Harper, S; Debreczeni, J; Breed, J; Wissler, L; Edman, K AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50011503 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50011503&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 49783903 103924056 CHEMBL3261927 ZINC36271851 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50091561 CN1Cc2ccc(cc2C1=O)-c1ccc(C[C@H](NC(=O)C2(N)CCOCC2)C#N)cc1 InChI=1S/C24H26N4O3/c1-28-15-19-7-6-18(13-21(19)22(28)29)17-4-2-16(3-5-17)12-20(14-25)27-23(30)24(26)8-10-31-11-9-24/h2-7,13,20H,8-12,15,26H2,1H3,(H,27,30)/t20-/m0/s1 ALYPEORYGVOPDI-FQEVSTJZSA-N 50011504 CHEMBL3261928 Dipeptidyl peptidase 1 5.0 ChEMBL 10.1021/jm401705g 10.7270/Q20866VB 24592859 Furber, M; Tiden, AK; Gardiner, P; Mete, A; Ford, R; Millichip, I; Stein, L; Mather, A; Kinchin, E; Luckhurst, C; Barber, S; Cage, P; Sanganee, H; Austin, R; Chohan, K; Beri, R; Thong, B; Wallace, A; Oreffo, V; Hutchinson, R; Harper, S; Debreczeni, J; Breed, J; Wissler, L; Edman, K AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50011504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50011504&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 49783985 103924057 CHEMBL3261928 ZINC36271991 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50091562 CC[C@H](N)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccccc1)C#N InChI=1S/C19H21N3O/c1-2-18(21)19(23)22-17(13-20)12-14-8-10-16(11-9-14)15-6-4-3-5-7-15/h3-11,17-18H,2,12,21H2,1H3,(H,22,23)/t17-,18-/m0/s1 DPOJEFZKFIWUGN-ROUUACIJSA-N 50186088 (S)-2-amino-N-((S)-2-(biphenyl-4-yl)-1-cyanoethyl)butanamide::(S)-2-amino-N-((S)-2-biphenyl-4-yl-1-cyano-ethyl)-butyramide::CHEMBL212521 Dipeptidyl peptidase 1 63 ChEMBL 10.1021/jm401705g 10.7270/Q20866VB 24592859 Furber, M; Tiden, AK; Gardiner, P; Mete, A; Ford, R; Millichip, I; Stein, L; Mather, A; Kinchin, E; Luckhurst, C; Barber, S; Cage, P; Sanganee, H; Austin, R; Chohan, K; Beri, R; Thong, B; Wallace, A; Oreffo, V; Hutchinson, R; Harper, S; Debreczeni, J; Breed, J; Wissler, L; Edman, K AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50186088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50186088&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 11771234 104070152 CHEMBL212521 ZINC36323060 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50091563 O=C(N[C@@H](Cc1ccc(cc1)-c1ccccc1)C#N)[C@@H]1CCCCN1 InChI=1S/C21H23N3O/c22-15-19(24-21(25)20-8-4-5-13-23-20)14-16-9-11-18(12-10-16)17-6-2-1-3-7-17/h1-3,6-7,9-12,19-20,23H,4-5,8,13-14H2,(H,24,25)/t19-,20-/m0/s1 AGQMDQHFBCAQCC-PMACEKPBSA-N 50011510 CHEMBL3261918 Dipeptidyl peptidase 1 158 ChEMBL 10.1021/jm401705g 10.7270/Q20866VB 24592859 Furber, M; Tiden, AK; Gardiner, P; Mete, A; Ford, R; Millichip, I; Stein, L; Mather, A; Kinchin, E; Luckhurst, C; Barber, S; Cage, P; Sanganee, H; Austin, R; Chohan, K; Beri, R; Thong, B; Wallace, A; Oreffo, V; Hutchinson, R; Harper, S; Debreczeni, J; Breed, J; Wissler, L; Edman, K AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50011510 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50011510&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 57999656 103924063 CHEMBL3261918 ZINC36272060 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50091564 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)[C@@H]1CCCCN1 InChI=1S/C22H22N4O/c23-14-17-6-10-19(11-7-17)18-8-4-16(5-9-18)13-20(15-24)26-22(27)21-3-1-2-12-25-21/h4-11,20-21,25H,1-3,12-13H2,(H,26,27)/t20-,21-/m0/s1 NWEHEPXTNMPJSH-SFTDATJTSA-N 50011505 CHEMBL3261919 Dipeptidyl peptidase 1 10.0 ChEMBL 10.1021/jm401705g 10.7270/Q20866VB 24592859 Furber, M; Tiden, AK; Gardiner, P; Mete, A; Ford, R; Millichip, I; Stein, L; Mather, A; Kinchin, E; Luckhurst, C; Barber, S; Cage, P; Sanganee, H; Austin, R; Chohan, K; Beri, R; Thong, B; Wallace, A; Oreffo, V; Hutchinson, R; Harper, S; Debreczeni, J; Breed, J; Wissler, L; Edman, K AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50011505 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50011505&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 42641892 103924058 CHEMBL3261919 ZINC36271870 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50091565 CSc1cc(ccc1C#N)-c1ccc(C[C@H](NC(=O)[C@@H]2CCCCN2)C#N)cc1 InChI=1S/C23H24N4OS/c1-29-22-13-18(9-10-19(22)14-24)17-7-5-16(6-8-17)12-20(15-25)27-23(28)21-4-2-3-11-26-21/h5-10,13,20-21,26H,2-4,11-12H2,1H3,(H,27,28)/t20-,21-/m0/s1 NMLYRXXREIIYKN-SFTDATJTSA-N 50011506 CHEMBL3261920 Dipeptidyl peptidase 1 1.000000 ChEMBL 10.1021/jm401705g 10.7270/Q20866VB 24592859 Furber, M; Tiden, AK; Gardiner, P; Mete, A; Ford, R; Millichip, I; Stein, L; Mather, A; Kinchin, E; Luckhurst, C; Barber, S; Cage, P; Sanganee, H; Austin, R; Chohan, K; Beri, R; Thong, B; Wallace, A; Oreffo, V; Hutchinson, R; Harper, S; Debreczeni, J; Breed, J; Wissler, L; Edman, K AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50011506 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50011506&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 42642459 103924059 CHEMBL3261920 ZINC36271952 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50091566 CN1Cc2cc(ccc2C1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CCCCN2)C#N)cc1 InChI=1S/C24H26N4O2/c1-28-15-19-13-18(9-10-21(19)24(28)30)17-7-5-16(6-8-17)12-20(14-25)27-23(29)22-4-2-3-11-26-22/h5-10,13,20,22,26H,2-4,11-12,15H2,1H3,(H,27,29)/t20-,22-/m0/s1 OWXGOHWYUAIZNU-UNMCSNQZSA-N 50011507 CHEMBL3261921 Dipeptidyl peptidase 1 7.9 ChEMBL 10.1021/jm401705g 10.7270/Q20866VB 24592859 Furber, M; Tiden, AK; Gardiner, P; Mete, A; Ford, R; Millichip, I; Stein, L; Mather, A; Kinchin, E; Luckhurst, C; Barber, S; Cage, P; Sanganee, H; Austin, R; Chohan, K; Beri, R; Thong, B; Wallace, A; Oreffo, V; Hutchinson, R; Harper, S; Debreczeni, J; Breed, J; Wissler, L; Edman, K AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50011507 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50011507&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90655967 103924060 CHEMBL3261921 ZINC36272054 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50091567 O[C@H]1CCN[C@@H](C1)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N InChI=1S/C22H22N4O2/c23-13-16-3-7-18(8-4-16)17-5-1-15(2-6-17)11-19(14-24)26-22(28)21-12-20(27)9-10-25-21/h1-8,19-21,25,27H,9-12H2,(H,26,28)/t19-,20-,21-/m0/s1 ZBEHEQLBNJJNRN-ACRUOGEOSA-N 50011508 CHEMBL3261922 Dipeptidyl peptidase 1 13 ChEMBL 10.1021/jm401705g 10.7270/Q20866VB 24592859 Furber, M; Tiden, AK; Gardiner, P; Mete, A; Ford, R; Millichip, I; Stein, L; Mather, A; Kinchin, E; Luckhurst, C; Barber, S; Cage, P; Sanganee, H; Austin, R; Chohan, K; Beri, R; Thong, B; Wallace, A; Oreffo, V; Hutchinson, R; Harper, S; Debreczeni, J; Breed, J; Wissler, L; Edman, K AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50011508 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50011508&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90655968 103924061 CHEMBL3261922 ZINC36272098 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50091568 CN1Cc2cc(ccc2C1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2C[C@@H](O)CCN2)C#N)cc1 InChI=1S/C24H26N4O3/c1-28-14-18-11-17(6-7-21(18)24(28)31)16-4-2-15(3-5-16)10-19(13-25)27-23(30)22-12-20(29)8-9-26-22/h2-7,11,19-20,22,26,29H,8-10,12,14H2,1H3,(H,27,30)/t19-,20-,22-/m0/s1 XXVWENSFIHCLPM-ONTIZHBOSA-N 50011509 CHEMBL3261923 Dipeptidyl peptidase 1 40 ChEMBL 10.1021/jm401705g 10.7270/Q20866VB 24592859 Furber, M; Tiden, AK; Gardiner, P; Mete, A; Ford, R; Millichip, I; Stein, L; Mather, A; Kinchin, E; Luckhurst, C; Barber, S; Cage, P; Sanganee, H; Austin, R; Chohan, K; Beri, R; Thong, B; Wallace, A; Oreffo, V; Hutchinson, R; Harper, S; Debreczeni, J; Breed, J; Wissler, L; Edman, K AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50011509 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50011509&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90655969 103924062 CHEMBL3261923 ZINC36271895 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500452 CS(=O)(=O)c1ccn(-c2ccc(C[C@H](NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)c(F)c2)c(=O)c1 InChI=1S/C22H23FN4O4S/c1-32(30,31)18-6-7-27(20(28)11-18)17-5-3-13(19(23)10-17)8-16(12-24)26-22(29)21-14-2-4-15(9-14)25-21/h3,5-7,10-11,14-16,21,25H,2,4,8-9H2,1H3,(H,26,29)/t14-,15+,16-,21-/m0/s1 KKPLONFOCYWZDO-YJXLLHPSSA-N 150592 US10238633, Example 266::US8987249, 266::US9713606, 266 Dipeptidyl peptidase 1 43.7 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150592 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150592&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430406 252824843 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500453 CC(C)N1CCCN(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H34FN5O/c1-16(2)29-8-3-9-30(11-10-29)21-7-5-17(22(25)14-21)12-20(15-26)28-24(31)23-18-4-6-19(13-18)27-23/h5,7,14,16,18-20,23,27H,3-4,6,8-13H2,1-2H3,(H,28,31)/t18-,19+,20-,23-/m0/s1 WFHYTCOTCREJLJ-SRYPRDQNSA-N 150593 US10238633, Example 267::US8987249, 267::US9713606, 267 Dipeptidyl peptidase 1 10.5 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150593 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150593&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430443 252824844 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500460 CS(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H24FN3O2S/c1-30(29)20-8-5-14(6-9-20)15-2-3-16(21(24)12-15)10-19(13-25)27-23(28)22-17-4-7-18(11-17)26-22/h2-3,5-6,8-9,12,17-19,22,26H,4,7,10-11H2,1H3,(H,27,28)/t17-,18+,19-,22-,30?/m0/s1 SDOAKBZNSFVUJC-NVFJITABSA-N 150600 US10238633, Example 274::US8987249, 274::US9713606, 274 Dipeptidyl peptidase 1 6.50 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150600 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150600&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430661 252824851 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500492 CNC(=O)Cc1ccc2[nH]c(=O)c3cc(CC(NC(=O)[C@H]4N[C@@H]5CC[C@H]4C5)C#N)ccc3c2c1 150632 US10238633, Example 306::US8987249, 306::US9713606, 306 Dipeptidyl peptidase 1 7.00 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150632 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150632&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937214 252824883 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50136332 O=C(N[C@@H](Cc1ccccc1)C#N)[C@@H]1CCCN1 InChI=1S/C14H17N3O/c15-10-12(9-11-5-2-1-3-6-11)17-14(18)13-7-4-8-16-13/h1-3,5-6,12-13,16H,4,7-9H2,(H,17,18)/t12-,13-/m0/s1 ONTXWGLODXXLKK-STQMWFEESA-N 50186092 (S)-N-((S)-1-cyano-2-phenylethyl)pyrrolidine-2-carboxamide::CHEMBL212514 Dipeptidyl peptidase 1 9637 ChEMBL 10.1016/j.bmcl.2006.01.102 10.7270/Q2639PC4 16647256 Bondebjerg, J; Fuglsang, H; Valeur, KR; Pedersen, J; Naerum, L Arpida A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50186092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50186092&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 44413251 104070156 CHEMBL212514 ZINC36338746 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50136336 CC[C@H](N)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccccc1)C#N InChI=1S/C19H21N3O/c1-2-18(21)19(23)22-17(13-20)12-14-8-10-16(11-9-14)15-6-4-3-5-7-15/h3-11,17-18H,2,12,21H2,1H3,(H,22,23)/t17-,18-/m0/s1 DPOJEFZKFIWUGN-ROUUACIJSA-N 50186088 (S)-2-amino-N-((S)-2-(biphenyl-4-yl)-1-cyanoethyl)butanamide::(S)-2-amino-N-((S)-2-biphenyl-4-yl-1-cyano-ethyl)-butyramide::CHEMBL212521 Dipeptidyl peptidase 1 13 ChEMBL 10.1016/j.bmcl.2006.01.102 10.7270/Q2639PC4 16647256 Bondebjerg, J; Fuglsang, H; Valeur, KR; Pedersen, J; Naerum, L Arpida A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50186088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50186088&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 11771234 104070152 CHEMBL212521 ZINC36323060 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50136337 NCC(=O)N[C@@H](Cc1ccccc1)C#N InChI=1S/C11H13N3O/c12-7-10(14-11(15)8-13)6-9-4-2-1-3-5-9/h1-5,10H,6,8,13H2,(H,14,15)/t10-/m0/s1 QLVGHFBUSGYCCG-JTQLQIEISA-N 50186094 (S)-2-amino-N-(1-cyano-2-phenylethyl)acetamide::CHEMBL379542 Dipeptidyl peptidase 1 4787 ChEMBL 10.1016/j.bmcl.2006.01.102 10.7270/Q2639PC4 16647256 Bondebjerg, J; Fuglsang, H; Valeur, KR; Pedersen, J; Naerum, L Arpida A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50186094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50186094&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 44413276 104070158 CHEMBL379542 ZINC36338741 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50136338 CC[C@H](N)C(=O)N[C@@H](C\C=C\c1ccccc1)C#N InChI=1S/C15H19N3O/c1-2-14(17)15(19)18-13(11-16)10-6-9-12-7-4-3-5-8-12/h3-9,13-14H,2,10,17H2,1H3,(H,18,19)/b9-6+/t13-,14-/m0/s1 VWMLDEXFDGYUGV-HXUSNMGPSA-N 50186089 (S)-2-amino-N-((S,E)-1-cyano-4-phenylbut-3-enyl)butanamide::CHEMBL211388 Dipeptidyl peptidase 1 137 ChEMBL 10.1016/j.bmcl.2006.01.102 10.7270/Q2639PC4 16647256 Bondebjerg, J; Fuglsang, H; Valeur, KR; Pedersen, J; Naerum, L Arpida A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50186089 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50186089&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 44413390 104070153 CHEMBL211388 ZINC36338748 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50136339 CC[C@H](N)C(=O)N[C@@H](Cc1ccccc1)C#N InChI=1S/C13H17N3O/c1-2-12(15)13(17)16-11(9-14)8-10-6-4-3-5-7-10/h3-7,11-12H,2,8,15H2,1H3,(H,16,17)/t11-,12-/m0/s1 FJZRVMNSJOVOGR-RYUDHWBXSA-N 50186091 (S)-2-amino-N-((S)-1-cyano-2-phenylethyl)butanamide::CHEMBL439145 Dipeptidyl peptidase 1 172 ChEMBL 10.1016/j.bmcl.2006.01.102 10.7270/Q2639PC4 16647256 Bondebjerg, J; Fuglsang, H; Valeur, KR; Pedersen, J; Naerum, L Arpida A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50186091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50186091&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 11736400 104070155 CHEMBL439145 ZINC36338747 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50136343 CC[C@H](N)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C#N InChI=1S/C13H16ClN3O/c1-2-12(16)13(18)17-11(8-15)7-9-3-5-10(14)6-4-9/h3-6,11-12H,2,7,16H2,1H3,(H,17,18)/t11-,12-/m0/s1 AVEAHVRCQRIZOC-RYUDHWBXSA-N 50186090 (S)-2-amino-N-((S)-2-(4-chlorophenyl)-1-cyanoethyl)butanamide::CHEMBL209998 Dipeptidyl peptidase 1 96 ChEMBL 10.1016/j.bmcl.2006.01.102 10.7270/Q2639PC4 16647256 Bondebjerg, J; Fuglsang, H; Valeur, KR; Pedersen, J; Naerum, L Arpida A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50186090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50186090&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 11817961 104070154 CHEMBL209998 ZINC36338743 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50136344 CC[C@H](N)C(=O)N[C@@H](CCc1ccccc1)C#N InChI=1S/C14H19N3O/c1-2-13(16)14(18)17-12(10-15)9-8-11-6-4-3-5-7-11/h3-7,12-13H,2,8-9,16H2,1H3,(H,17,18)/t12-,13-/m0/s1 YPVDHPRIHVAPOT-STQMWFEESA-N 50186093 (S)-2-amino-N-((S)-1-cyano-3-phenylpropyl)butanamide::CHEMBL212523 Dipeptidyl peptidase 1 822 ChEMBL 10.1016/j.bmcl.2006.01.102 10.7270/Q2639PC4 16647256 Bondebjerg, J; Fuglsang, H; Valeur, KR; Pedersen, J; Naerum, L Arpida A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50186093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50186093&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 11334066 104070157 CHEMBL212523 ZINC34485746 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50136348 N[C@@H](Cc1ccccc1)C(=O)NC(Cc1ccccc1)C#N InChI=1S/C18H19N3O/c19-13-16(11-14-7-3-1-4-8-14)21-18(22)17(20)12-15-9-5-2-6-10-15/h1-10,16-17H,11-12,20H2,(H,21,22)/t16?,17-/m0/s1 YJRDNSKPBMYKNH-DJNXLDHESA-N 50186087 (2S)-2-amino-N-(1-cyano-2-phenylethyl)-3-phenylpropanamide::CHEMBL377768 Dipeptidyl peptidase 1 6290 ChEMBL 10.1016/j.bmcl.2006.01.102 10.7270/Q2639PC4 16647256 Bondebjerg, J; Fuglsang, H; Valeur, KR; Pedersen, J; Naerum, L Arpida A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50186087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50186087&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 44413250 104070151 CHEMBL377768 ZINC36338745 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50140333 Cc1cccc(O[C@H]2CCN3C[C@H]2OC3=O)c1C InChI=1S/C14H17NO3/c1-9-4-3-5-11(10(9)2)17-12-6-7-15-8-13(12)18-14(15)16/h3-5,12-13H,6-8H2,1-2H3/t12-,13+/m0/s1 SIIJWJNEODXHNY-QWHCGFSZSA-N 50201701 CHEMBL390474::cis-4-(2,3-dimethylphenoxy)-6-oxa-1-aza-bicyclo[3.2.1]octan-7-one Dipeptidyl peptidase 1 18 ChEMBL 10.1016/j.bmcl.2006.12.014 10.7270/Q2QN66DT 17196818 Epple, R; Urbina, HD; Russo, R; Liu, H; Mason, D; Bursulaya, B; Tumanut, C; Li, J; Harris, JL The Genomics Institute of the Novartis Research Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50201701 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50201701&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 16664855 104081443 CHEMBL390474 ZINC28705273 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50140334 Cc1cccc(O[C@H]2CCN3C[C@@H]2OC3=O)c1C InChI=1S/C14H17NO3/c1-9-4-3-5-11(10(9)2)17-12-6-7-15-8-13(12)18-14(15)16/h3-5,12-13H,6-8H2,1-2H3/t12-,13-/m0/s1 SIIJWJNEODXHNY-STQMWFEESA-N 50201698 CHEMBL230473::rac-trans4-(2,3-dimethylphenoxy)-6-oxa-1-aza-bicyclo[3.2.1]octan-7-one Dipeptidyl peptidase 1 1727 ChEMBL 10.1016/j.bmcl.2006.12.014 10.7270/Q2QN66DT 17196818 Epple, R; Urbina, HD; Russo, R; Liu, H; Mason, D; Bursulaya, B; Tumanut, C; Li, J; Harris, JL The Genomics Institute of the Novartis Research Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50201698 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50201698&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 24900755 104081440 CHEMBL230473 ZINC28705270 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50140380 Cc1cccc(O[C@@H]2CCNC[C@@H]2O)c1C InChI=1S/C13H19NO2/c1-9-4-3-5-12(10(9)2)16-13-6-7-14-8-11(13)15/h3-5,11,13-15H,6-8H2,1-2H3/t11-,13+/m0/s1 ZHFIAFNZGWCLHU-WCQYABFASA-N 50201704 (3S,4R)-4-(2,3-dimethylphenoxy)piperidin-3-ol::CHEMBL441907 Dipeptidyl peptidase 1 >100000 ChEMBL 10.1016/j.bmcl.2006.12.014 10.7270/Q2QN66DT 17196818 Epple, R; Urbina, HD; Russo, R; Liu, H; Mason, D; Bursulaya, B; Tumanut, C; Li, J; Harris, JL The Genomics Institute of the Novartis Research Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50201704 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50201704&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 6917747 104081446 CHEMBL441907 ZINC01842838 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50140381 Cc1cccc(O[C@@H]2CCNC[C@H]2O)c1C InChI=1S/C13H19NO2/c1-9-4-3-5-12(10(9)2)16-13-6-7-14-8-11(13)15/h3-5,11,13-15H,6-8H2,1-2H3/t11-,13-/m1/s1 ZHFIAFNZGWCLHU-DGCLKSJQSA-N 50201706 (3R,4R)-4-(2,3-dimethylphenoxy)piperidin-3-ol::CHEMBL230479 Dipeptidyl peptidase 1 >100000 ChEMBL 10.1016/j.bmcl.2006.12.014 10.7270/Q2QN66DT 17196818 Epple, R; Urbina, HD; Russo, R; Liu, H; Mason, D; Bursulaya, B; Tumanut, C; Li, J; Harris, JL The Genomics Institute of the Novartis Research Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50201706 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50201706&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 13186896 104081448 CHEMBL230479 ZINC28705289 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50140382 Br[C@H]1CCN2C[C@@H]1OC2=O InChI=1S/C6H8BrNO2/c7-4-1-2-8-3-5(4)10-6(8)9/h4-5H,1-3H2/t4-,5-/m0/s1 VVSXVRNUMNINTL-WHFBIAKZSA-N 50201703 (1S,2S)-2-bromo-7-oxa-5-aza-bicyclo[3.2.1]octan-6-one::CHEMBL397972 Dipeptidyl peptidase 1 >10000 ChEMBL 10.1016/j.bmcl.2006.12.014 10.7270/Q2QN66DT 17196818 Epple, R; Urbina, HD; Russo, R; Liu, H; Mason, D; Bursulaya, B; Tumanut, C; Li, J; Harris, JL The Genomics Institute of the Novartis Research Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50201703 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50201703&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 24901102 104081445 CHEMBL397972 ZINC28705286 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50140383 CN1CC(COc2cccc(C)c2C)OC1=O InChI=1S/C13H17NO3/c1-9-5-4-6-12(10(9)2)16-8-11-7-14(3)13(15)17-11/h4-6,11H,7-8H2,1-3H3 UWNKJJCNLMBGKB-UHFFFAOYSA-N 50201707 5-((2,3-dimethylphenoxy)methyl)-3-methyloxazolidin-2-one::CHEMBL397973 Dipeptidyl peptidase 1 >100000 ChEMBL 10.1016/j.bmcl.2006.12.014 10.7270/Q2QN66DT 17196818 Epple, R; Urbina, HD; Russo, R; Liu, H; Mason, D; Bursulaya, B; Tumanut, C; Li, J; Harris, JL The Genomics Institute of the Novartis Research Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50201707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50201707&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 44426056 104081449 CHEMBL397973 ZINC28705297 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50140386 CC(C)CO[C@H]1CCN2C[C@H]1OC2=O InChI=1S/C10H17NO3/c1-7(2)6-13-8-3-4-11-5-9(8)14-10(11)12/h7-9H,3-6H2,1-2H3/t8-,9+/m0/s1 YOGVFFRGTMXMRZ-DTWKUNHWSA-N 50201699 (1R,2S)-2-isobutoxy-7-oxa-5-aza-bicyclo[3.2.1]octan-6-one::CHEMBL230478 Dipeptidyl peptidase 1 191 ChEMBL 10.1016/j.bmcl.2006.12.014 10.7270/Q2QN66DT 17196818 Epple, R; Urbina, HD; Russo, R; Liu, H; Mason, D; Bursulaya, B; Tumanut, C; Li, J; Harris, JL The Genomics Institute of the Novartis Research Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50201699 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50201699&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 24901101 104081441 CHEMBL230478 ZINC28705284 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50140387 O=C1O[C@@H]2CN1CC[C@@H]2OCc1ccccc1 InChI=1S/C13H15NO3/c15-13-14-7-6-11(12(8-14)17-13)16-9-10-4-2-1-3-5-10/h1-5,11-12H,6-9H2/t11-,12+/m0/s1 CFOTUZHUTFRFQA-NWDGAFQWSA-N 50201705 (1R,2S)-2-(benzyloxy)-7-oxa-5-aza-bicyclo[3.2.1]octan-6-one::CHEMBL390475 Dipeptidyl peptidase 1 403 ChEMBL 10.1016/j.bmcl.2006.12.014 10.7270/Q2QN66DT 17196818 Epple, R; Urbina, HD; Russo, R; Liu, H; Mason, D; Bursulaya, B; Tumanut, C; Li, J; Harris, JL The Genomics Institute of the Novartis Research Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50201705 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50201705&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 24901100 104081447 CHEMBL390475 ZINC28705281 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50140411 O=C1O[C@@H]2CN1CC[C@@H]2Oc1ccccc1 InChI=1S/C12H13NO3/c14-12-13-7-6-10(11(8-13)16-12)15-9-4-2-1-3-5-9/h1-5,10-11H,6-8H2/t10-,11+/m0/s1 GCWIICJLIHIUNY-WDEREUQCSA-N 50201700 (1R,2S)-2-phenoxy-7-oxa-5-aza-bicyclo[3.2.1]octan-6-one::CHEMBL230474 Dipeptidyl peptidase 1 29 ChEMBL 10.1016/j.bmcl.2006.12.014 10.7270/Q2QN66DT 17196818 Epple, R; Urbina, HD; Russo, R; Liu, H; Mason, D; Bursulaya, B; Tumanut, C; Li, J; Harris, JL The Genomics Institute of the Novartis Research Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50201700 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50201700&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 24901099 104081442 CHEMBL230474 ZINC28705278 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50140412 S=C1O[C@@H]2CN1CC[C@@H]2Oc1ccccc1 InChI=1S/C12H13NO2S/c16-12-13-7-6-10(11(8-13)15-12)14-9-4-2-1-3-5-9/h1-5,10-11H,6-8H2/t10-,11+/m0/s1 BMIOGAIQRVIVKQ-WDEREUQCSA-N 50201702 (1R,2S)-2-phenoxy-7-oxa-5-aza-bicyclo[3.2.1]octane-6-thione::CHEMBL390643 Dipeptidyl peptidase 1 606 ChEMBL 10.1016/j.bmcl.2006.12.014 10.7270/Q2QN66DT 17196818 Epple, R; Urbina, HD; Russo, R; Liu, H; Mason, D; Bursulaya, B; Tumanut, C; Li, J; Harris, JL The Genomics Institute of the Novartis Research Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50201702 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50201702&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 44426055 104081444 CHEMBL390643 ZINC28705276 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50147417 CCC[C@H](N)C(=O)N[C@@H](CCc1ccccc1)\C=C\S(=O)(=O)c1ccccc1 InChI=1S/C22H28N2O3S/c1-2-9-21(23)22(25)24-19(15-14-18-10-5-3-6-11-18)16-17-28(26,27)20-12-7-4-8-13-20/h3-8,10-13,16-17,19,21H,2,9,14-15,23H2,1H3,(H,24,25)/b17-16+/t19-,21-/m0/s1 GLJZTHKUTGOBFU-LIIHMFIASA-N 50247192 (S)-2-amino-N-((S)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)pentanamide::CHEMBL514348 Dipeptidyl peptidase 1 100 ChEMBL 10.1016/j.bmc.2008.02.002 10.7270/Q20R9P6K 18313933 Li, J; Petrassi, HM; Tumanut, C; Masick, BT; Trussell, C; Harris, JL Genomics Institute of the Novartis Research Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50247192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50247192&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 23643986 104102322 CHEMBL514348 ZINC40900276 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50147419 CCC[C@H](N)C(=O)N[C@@H](CCc1ccccc1)\C=C\S(=O)(=O)c1ccccc1 InChI=1S/C22H28N2O3S/c1-2-9-21(23)22(25)24-19(15-14-18-10-5-3-6-11-18)16-17-28(26,27)20-12-7-4-8-13-20/h3-8,10-13,16-17,19,21H,2,9,14-15,23H2,1H3,(H,24,25)/b17-16+/t19-,21-/m0/s1 GLJZTHKUTGOBFU-LIIHMFIASA-N 50247192 (S)-2-amino-N-((S)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)pentanamide::CHEMBL514348 Dipeptidyl peptidase 1 70 ChEMBL 10.1016/j.bmc.2008.02.002 10.7270/Q20R9P6K 18313933 Li, J; Petrassi, HM; Tumanut, C; Masick, BT; Trussell, C; Harris, JL Genomics Institute of the Novartis Research Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50247192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50247192&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 23643986 104102322 CHEMBL514348 ZINC40900276 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50147423 CC(C)C[C@H](NC(=O)N1CCOCC1)C(=O)N[C@@H](CCc1ccccc1)C=CS(=O)(=O)c1ccccc1 InChI=1S/C28H37N3O5S/c1-22(2)21-26(30-28(33)31-16-18-36-19-17-31)27(32)29-24(14-13-23-9-5-3-6-10-23)15-20-37(34,35)25-11-7-4-8-12-25/h3-12,15,20,22,24,26H,13-14,16-19,21H2,1-2H3,(H,29,32)(H,30,33)/t24-,26-/m0/s1 YUMYYTORLYHUFW-AHWVRZQESA-N 50243232 CHEMBL486232::GNF-PF-5434::N-((S)-4-methyl-1-oxo-1-((S)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-ylamino)pentan-2-yl)morpholine-4-carboxamide::N~2~-(MORPHOLIN-4-YLCARBONYL)-N~1~-[(1S,2E)-1-(2-PHENYLETHYL)-3-(PHENYLSULFONYL)PROP-2-ENYL]-D-LEUCINAMIDE Dipeptidyl peptidase 1 2600 ChEMBL 10.1016/j.bmc.2008.02.002 10.7270/Q20R9P6K 18313933 Li, J; Petrassi, HM; Tumanut, C; Masick, BT; Trussell, C; Harris, JL Genomics Institute of the Novartis Research Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50243232 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50243232&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 5287864 104099548 CHEMBL486232 ZINC12503957 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50147424 CC[C@H](N)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccccc1)C#N InChI=1S/C19H21N3O/c1-2-18(21)19(23)22-17(13-20)12-14-8-10-16(11-9-14)15-6-4-3-5-7-15/h3-11,17-18H,2,12,21H2,1H3,(H,22,23)/t17-,18-/m0/s1 DPOJEFZKFIWUGN-ROUUACIJSA-N 50186088 (S)-2-amino-N-((S)-2-(biphenyl-4-yl)-1-cyanoethyl)butanamide::(S)-2-amino-N-((S)-2-biphenyl-4-yl-1-cyano-ethyl)-butyramide::CHEMBL212521 Dipeptidyl peptidase 1 10000 ChEMBL 10.1016/j.bmc.2008.02.002 10.7270/Q20R9P6K 18313933 Li, J; Petrassi, HM; Tumanut, C; Masick, BT; Trussell, C; Harris, JL Genomics Institute of the Novartis Research Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50186088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50186088&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 11771234 104070152 CHEMBL212521 ZINC36323060 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50147425 CC(C)C[C@H](NC(=O)N1CCOCC1)C(=O)N[C@@H](CCc1ccccc1)C=CS(=O)(=O)c1ccccc1 InChI=1S/C28H37N3O5S/c1-22(2)21-26(30-28(33)31-16-18-36-19-17-31)27(32)29-24(14-13-23-9-5-3-6-10-23)15-20-37(34,35)25-11-7-4-8-12-25/h3-12,15,20,22,24,26H,13-14,16-19,21H2,1-2H3,(H,29,32)(H,30,33)/t24-,26-/m0/s1 YUMYYTORLYHUFW-AHWVRZQESA-N 50243232 CHEMBL486232::GNF-PF-5434::N-((S)-4-methyl-1-oxo-1-((S)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-ylamino)pentan-2-yl)morpholine-4-carboxamide::N~2~-(MORPHOLIN-4-YLCARBONYL)-N~1~-[(1S,2E)-1-(2-PHENYLETHYL)-3-(PHENYLSULFONYL)PROP-2-ENYL]-D-LEUCINAMIDE Dipeptidyl peptidase 1 4000 ChEMBL 10.1016/j.bmc.2008.02.002 10.7270/Q20R9P6K 18313933 Li, J; Petrassi, HM; Tumanut, C; Masick, BT; Trussell, C; Harris, JL Genomics Institute of the Novartis Research Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50243232 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50243232&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 5287864 104099548 CHEMBL486232 ZINC12503957 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50147426 CC[C@H](N)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccccc1)C#N InChI=1S/C19H21N3O/c1-2-18(21)19(23)22-17(13-20)12-14-8-10-16(11-9-14)15-6-4-3-5-7-15/h3-11,17-18H,2,12,21H2,1H3,(H,22,23)/t17-,18-/m0/s1 DPOJEFZKFIWUGN-ROUUACIJSA-N 50186088 (S)-2-amino-N-((S)-2-(biphenyl-4-yl)-1-cyanoethyl)butanamide::(S)-2-amino-N-((S)-2-biphenyl-4-yl-1-cyano-ethyl)-butyramide::CHEMBL212521 Dipeptidyl peptidase 1 6100 ChEMBL 10.1016/j.bmc.2008.02.002 10.7270/Q20R9P6K 18313933 Li, J; Petrassi, HM; Tumanut, C; Masick, BT; Trussell, C; Harris, JL Genomics Institute of the Novartis Research Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50186088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50186088&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 11771234 104070152 CHEMBL212521 ZINC36323060 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50160110 CS[C@@H]1CN[C@@H](C1)C(=O)NC1(CC1Cc1ccccc1)C#N InChI=1S/C17H21N3OS/c1-22-14-8-15(19-10-14)16(21)20-17(11-18)9-13(17)7-12-5-3-2-4-6-12/h2-6,13-15,19H,7-10H2,1H3,(H,20,21)/t13?,14-,15-,17?/m0/s1 XSOLZYSVIWKGHX-GWUWNPHMSA-N 50310705 CHEMBL1077666::Cis-(2S,4S)-N-(2-benzyl-1-cyanocyclopropyl)-4-(methylthio)pyrrolidine-2-carboxamide Dipeptidyl peptidase 1 192 ChEMBL 10.1016/j.bmcl.2009.07.114 10.7270/Q298874W 19665376 Guay, D; Beaulieu, C; Truchon, JF; Jagadeeswar Reddy, T; Zamboni, R; Bayly, CI; Methot, N; Rubin, J; Ethier, D; David Percival, M Merck Frosst Canada & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310705 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310705&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 46882915 104145066 CHEMBL1077666 ZINC48999403 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50160113 F[C@@H]1CN[C@@H](C1)C(=O)NC1(CC1Cc1ccccc1)C#N InChI=1S/C16H18FN3O/c17-13-7-14(19-9-13)15(21)20-16(10-18)8-12(16)6-11-4-2-1-3-5-11/h1-5,12-14,19H,6-9H2,(H,20,21)/t12?,13-,14-,16?/m0/s1 YUWXKYWHTIMUMG-WJEHIRDRSA-N 50310704 CHEMBL1078356::Cis-(2S,4S)-N-(2-benzyl-1-cyanocyclopropyl)-4-fluoropyrrolidine-2-carboxamide Dipeptidyl peptidase 1 523 ChEMBL 10.1016/j.bmcl.2009.07.114 10.7270/Q298874W 19665376 Guay, D; Beaulieu, C; Truchon, JF; Jagadeeswar Reddy, T; Zamboni, R; Bayly, CI; Methot, N; Rubin, J; Ethier, D; David Percival, M Merck Frosst Canada & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310704 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310704&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 46882914 104145065 CHEMBL1078356 ZINC49014073 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500226 Cc1c(cnn1C)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H24FN5O/c1-12-18(11-24-27(12)2)13-3-4-14(19(22)9-13)7-17(10-23)26-21(28)20-15-5-6-16(8-15)25-20/h3-4,9,11,15-17,20,25H,5-8H2,1-2H3,(H,26,28)/t15-,16+,17-,20-/m0/s1 BXMGRZWIJVZYAS-CLWJZODNSA-N 150365 US10238633, Example 39::US8987249, 39::US9713606, 65 Dipeptidyl peptidase 1 5.10 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150365 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150365&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430769 252824616 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500227 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@H]2C[C@@H]1[C@@H]1C[C@H]21)C#N)-c1ccc(s1)C#N InChI=1S/C22H19FN4OS/c23-18-6-12(20-4-3-14(10-25)29-20)2-1-11(18)5-13(9-24)26-22(28)21-17-8-19(27-21)16-7-15(16)17/h1-4,6,13,15-17,19,21,27H,5,7-8H2,(H,26,28)/t13-,15+,16-,17+,19-,21-/m0/s1 LWDWTRJKZPTFHH-ARFSGQLGSA-N 150366 US8987249, 40::US9713606, 40 Dipeptidyl peptidase 1 5.10 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150366 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150366&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430770 252824617 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500188 CN1Cc2ccc(cc2C1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C25H27FN4O/c1-30-13-19-5-3-15(8-20(19)14-30)16-2-4-17(23(26)11-16)9-22(12-27)29-25(31)24-18-6-7-21(10-18)28-24/h2-5,8,11,18,21-22,24,28H,6-7,9-10,13-14H2,1H3,(H,29,31)/t18-,21+,22-,24-/m0/s1 GQBRPHSHOCUJAG-ASLXYRGWSA-N 150327 US10238633, Example 1::US8987249, 1::US9713606, 1 Dipeptidyl peptidase 1 8.60 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150327 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150327&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90414082 252824578 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500190 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2C(=O)OCc2c1 InChI=1S/C24H22FN3O3/c25-21-10-14(13-4-6-20-17(7-13)12-31-24(20)30)1-2-15(21)8-19(11-26)28-23(29)22-16-3-5-18(9-16)27-22/h1-2,4,6-7,10,16,18-19,22,27H,3,5,8-9,12H2,(H,28,29)/t16-,18+,19-,22-/m0/s1 WTHQKFUPVXDWIU-ZBPHCFQXSA-N 150329 US10238633, Example 3::US8987249, 3::US9713606, 3 Dipeptidyl peptidase 1 0.700 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150329 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150329&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90413943 252824580 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500191 CS(=O)(=O)c1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H24FN3O3S/c1-31(29,30)20-4-2-3-14(11-20)15-5-6-16(21(24)12-15)9-19(13-25)27-23(28)22-17-7-8-18(10-17)26-22/h2-6,11-12,17-19,22,26H,7-10H2,1H3,(H,27,28)/t17-,18+,19-,22-/m0/s1 SLANNUBDKTXJNP-WEMPKCCASA-N 150330 US10238633, Example 4::US8987249, 4::US9713606, 4 Dipeptidyl peptidase 1 1.40 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150330 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150330&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90415865 252824581 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500192 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-n1cc(nn1)-c1ccc2[nH]ccc2c1 263576 US10238633, Example 5::US9713606, 5 Dipeptidyl peptidase 1 4.00 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263576 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263576&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90413568 377002480 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500193 CN1CCN(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H28FN5O/c1-26-6-8-27(9-7-26)18-5-3-14(19(22)12-18)10-17(13-23)25-21(28)20-15-2-4-16(11-15)24-20/h3,5,12,15-17,20,24H,2,4,6-11H2,1H3,(H,25,28)/t15-,16+,17-,20-/m0/s1 ZECDJSBLEVMTSQ-CLWJZODNSA-N 150332 US10238633, Example 6::US8987249, 6::US9713606, 6 Dipeptidyl peptidase 1 10.7 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150332 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150332&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90413749 252824583 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500194 CC(=O)n1nc(cc1C)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H24FN5O2/c1-12-7-20(27-28(12)13(2)29)15-4-3-14(19(23)10-15)8-18(11-24)26-22(30)21-16-5-6-17(9-16)25-21/h3-4,7,10,16-18,21,25H,5-6,8-9H2,1-2H3,(H,26,30)/t16-,17+,18?,21-/m0/s1 LZLTXNWOZBVHCY-APZTZJSISA-N 150333 US10238633, Example 7::US8987249, 7::US9713606, 7 Dipeptidyl peptidase 1 1.90 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150333 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150333&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90413606 252824584 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500200 COC(=O)Cn1cc(cn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H24FN5O3/c1-31-20(29)12-28-11-16(10-25-28)13-2-3-14(19(23)8-13)6-18(9-24)27-22(30)21-15-4-5-17(7-15)26-21/h2-3,8,10-11,15,17-18,21,26H,4-7,12H2,1H3,(H,27,30)/t15-,17+,18-,21-/m0/s1 NHUZJCGXGLXXCK-DKXUYOFUSA-N 150339 US10238633, Example 13::US8987249, 13::US9713606, 13 Dipeptidyl peptidase 1 1.90 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150339 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150339&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430783 252824590 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500228 Fc1cc(ccc1CC(NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2C(=O)NCc2c1 InChI=1S/C24H23FN4O2/c25-21-10-14(13-4-6-20-17(7-13)12-27-23(20)30)1-2-15(21)8-19(11-26)29-24(31)22-16-3-5-18(9-16)28-22/h1-2,4,6-7,10,16,18-19,22,28H,3,5,8-9,12H2,(H,27,30)(H,29,31)/t16-,18+,19?,22-/m0/s1 AUFRBRNWPXRXNC-AAEOLZRXSA-N 150367 US10238633, Example 41::US8987249, 41::US9713606, 41 Dipeptidyl peptidase 1 5.30 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150367 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150367&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430724 252824618 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500229 CN1CCc2cc(ccc2C1=O)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C26H27FN4O2/c1-31-9-8-17-10-15(5-7-22(17)26(31)33)16-2-3-18(23(27)13-16)11-21(14-28)30-25(32)24-19-4-6-20(12-19)29-24/h2-3,5,7,10,13,19-21,24,29H,4,6,8-9,11-12H2,1H3,(H,30,32)/t19-,20+,21-,24-/m0/s1 XZKCAVQABJPIBE-XARGGIHNSA-N 150368 US10238633, Example 42::US8987249, 42::US9713606, 42 Dipeptidyl peptidase 1 5.30 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150368 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150368&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430764 252824619 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500230 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCN2CCOCC2C1 InChI=1S/C23H30FN5O2/c24-21-11-19(29-6-5-28-7-8-31-14-20(28)13-29)4-2-15(21)9-18(12-25)27-23(30)22-16-1-3-17(10-16)26-22/h2,4,11,16-18,20,22,26H,1,3,5-10,13-14H2,(H,27,30)/t16-,17+,18-,20?,22-/m0/s1 SOLOVPGTCODBHF-AEJWZEPGSA-N 150369 US10238633, Example 43::US8987249, 43::US9713606, 43 Dipeptidyl peptidase 1 5.60 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150369 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150369&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430331 252824620 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500231 COCCn1cc(cn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H26FN5O2/c1-30-7-6-28-13-17(12-25-28)14-2-3-15(20(23)10-14)8-19(11-24)27-22(29)21-16-4-5-18(9-16)26-21/h2-3,10,12-13,16,18-19,21,26H,4-9H2,1H3,(H,27,29)/t16-,18+,19-,21-/m0/s1 IQMJMZXJSJWJBP-KRQVXIAISA-N 150370 US10238633, Example 44::US8987249, 44::US9713606, 44 Dipeptidyl peptidase 1 5.90 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150370 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150370&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443235 252824621 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500232 Fc1cc(ccc1C[C@@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2ncsc2c1 InChI=1S/C23H21FN4OS/c24-19-9-13(14-4-6-20-21(10-14)30-12-26-20)1-2-15(19)7-18(11-25)28-23(29)22-16-3-5-17(8-16)27-22/h1-2,4,6,9-10,12,16-18,22,27H,3,5,7-8H2,(H,28,29)/t16-,17+,18+,22-/m0/s1 MAGRORJEPPDWJZ-FBAVSBLXSA-N 150371 US10238633, Example 45::US8987249, 45::US9713606, 45 Dipeptidyl peptidase 1 6.30 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150371 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150371&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430332 252824622 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500210 CC(C)(C)n1cc(cn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H28FN5O/c1-23(2,3)29-13-17(12-26-29)14-4-5-15(20(24)10-14)8-19(11-25)28-22(30)21-16-6-7-18(9-16)27-21/h4-5,10,12-13,16,18-19,21,27H,6-9H2,1-3H3,(H,28,30)/t16-,18+,19-,21-/m0/s1 HVHUNYHQWGGPMT-KRQVXIAISA-N 150349 US10238633, Example 23::US8987249, 23::US9713606, 23 Dipeptidyl peptidase 1 3.70 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150349 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150349&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430551 252824600 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500211 CN1C(=O)Cc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1F InChI=1S/C25H24F2N4O2/c1-31-20-10-13(2-3-14(20)11-21(31)32)19-7-5-15(22(26)23(19)27)8-18(12-28)30-25(33)24-16-4-6-17(9-16)29-24/h2-3,5,7,10,16-18,24,29H,4,6,8-9,11H2,1H3,(H,30,33)/t16-,17+,18-,24-/m0/s1 LJUVJDUKKVZRFZ-AIDSWVIKSA-N 150350 US10238633, Example 24::US8987249, 24::US9713606, 24 Dipeptidyl peptidase 1 3.70 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150350 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150350&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430553 252824601 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500233 CCc1ccc(s1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H24FN3OS/c1-2-18-7-8-20(28-18)14-4-3-13(19(23)11-14)9-17(12-24)26-22(27)21-15-5-6-16(10-15)25-21/h3-4,7-8,11,15-17,21,25H,2,5-6,9-10H2,1H3,(H,26,27)/t15-,16+,17-,21-/m0/s1 OHWUOLYXGMTXDK-DLRJPAPCSA-N 263617 US9713606, 46 Dipeptidyl peptidase 1 6.90 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263617&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118966875 377002521 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500234 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-n1cc(COc2ccccc2)nn1 InChI=1S/C25H25FN6O2/c26-23-12-21(32-14-20(30-31-32)15-34-22-4-2-1-3-5-22)9-7-16(23)10-19(13-27)29-25(33)24-17-6-8-18(11-17)28-24/h1-5,7,9,12,14,17-19,24,28H,6,8,10-11,15H2,(H,29,33)/t17-,18+,19-,24-/m0/s1 YQMDZGGJGGSBDR-YDLHNXBPSA-N 150373 US10238633, Example 47::US8987249, 47::US9713606, 47 Dipeptidyl peptidase 1 7.20 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150373 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150373&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90440137 252824624 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500235 CC(C)CC(=O)n1cc(cn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H28FN5O2/c1-14(2)7-22(31)30-13-18(12-27-30)15-3-4-16(21(25)10-15)8-20(11-26)29-24(32)23-17-5-6-19(9-17)28-23/h3-4,10,12-14,17,19-20,23,28H,5-9H2,1-2H3,(H,29,32)/t17-,19+,20-,23-/m0/s1 HRUNAKRSSYTYRA-USKVXJDGSA-N 150374 US10238633, Example 48::US8987249, 48::US9713606, 48 Dipeptidyl peptidase 1 7.20 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150374 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150374&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443268 252824625 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500201 CS(=O)(=O)c1cc(ccc1C#N)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H23FN4O3S/c1-33(31,32)22-11-15(3-5-18(22)12-26)14-2-4-16(21(25)10-14)8-20(13-27)29-24(30)23-17-6-7-19(9-17)28-23/h2-5,10-11,17,19-20,23,28H,6-9H2,1H3,(H,29,30)/t17-,19+,20-,23-/m0/s1 AUHJWFLPELHPMB-USKVXJDGSA-N 150340 US10238633, Example 14::US8987249, 14::US9713606, 14 Dipeptidyl peptidase 1 2.00 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150340&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443035 252824591 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500221 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2COC(=O)c2c1 InChI=1S/C24H22FN3O3/c25-21-10-14(13-2-4-17-12-31-24(30)20(17)9-13)1-3-15(21)7-19(11-26)28-23(29)22-16-5-6-18(8-16)27-22/h1-4,9-10,16,18-19,22,27H,5-8,12H2,(H,28,29)/t16-,18+,19-,22-/m0/s1 IHMLKNVVWQAOBN-ZBPHCFQXSA-N 150360 US10238633, Example 34::US8987249, 34::US9713606, 34 Dipeptidyl peptidase 1 4.60 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150360 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150360&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430302 252824611 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500222 Fc1cc(ccc1CC(NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc(C#N)c(F)c1 InChI=1S/C23H20F2N4O/c24-20-9-13(14-2-4-17(11-26)21(25)10-14)1-3-15(20)7-19(12-27)29-23(30)22-16-5-6-18(8-16)28-22/h1-4,9-10,16,18-19,22,28H,5-8H2,(H,29,30)/t16-,18+,19?,22-/m0/s1 ZACSQEJERMQYBO-AAEOLZRXSA-N 150361 US10238633, Example 35::US8987249, 35::US9713606, 35 Dipeptidyl peptidase 1 4.60 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150361 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150361&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430303 252824612 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500189 CN1C(=O)Cc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C25H25FN4O2/c1-30-22-11-15(3-5-17(22)12-23(30)31)14-2-4-16(21(26)10-14)8-20(13-27)29-25(32)24-18-6-7-19(9-18)28-24/h2-5,10-11,18-20,24,28H,6-9,12H2,1H3,(H,29,32)/t18-,19+,20-,24-/m0/s1 MNEOBAAFLAQMKF-VKDGWMQASA-N 150328 US10238633, Example 2::US8987249, 2::US9713606, 2 Dipeptidyl peptidase 1 2.00 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150328 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150328&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90414333 252824579 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500195 O=C(NC(Cc1ccc2[nH]ncc2c1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 150334 US10238633, Example 8::US8987249, 8::US9713606, 8 Dipeptidyl peptidase 1 679 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150334&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90415654 252824585 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500196 O=C(NC(Cc1ccc2c3ccccc3[nH]c(=O)c2c1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 150335 US10238633, Example 9::US8987249, 9::US9713606, 9 Dipeptidyl peptidase 1 9.60 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150335 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150335&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937188 252824586 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500225 CC(=O)NCCn1cc(cn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H27FN6O2/c1-14(31)26-6-7-30-13-18(12-27-30)15-2-3-16(21(24)10-15)8-20(11-25)29-23(32)22-17-4-5-19(9-17)28-22/h2-3,10,12-13,17,19-20,22,28H,4-9H2,1H3,(H,26,31)(H,29,32)/t17-,19+,20-,22-/m0/s1 AZUWHWHOUQWSGG-UFGBVDADSA-N 150364 US10238633, Example 38::US8987249, 38::US9713606, 38 Dipeptidyl peptidase 1 4.80 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150364 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150364&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937189 252824615 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500197 CN1C(=O)C(=O)c2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C25H23FN4O3/c1-30-21-11-14(5-7-19(21)23(31)25(30)33)13-2-3-15(20(26)10-13)8-18(12-27)29-24(32)22-16-4-6-17(9-16)28-22/h2-3,5,7,10-11,16-18,22,28H,4,6,8-9H2,1H3,(H,29,32)/t16-,17+,18-,22-/m0/s1 MQKJSVBPRAMRJU-SUWCGCSTSA-N 150336 US10238633, Example 10::US8987249, 10::US9713606, 10 Dipeptidyl peptidase 1 1.50 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150336&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443233 252824587 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500198 Fc1cc(ccc1CC(NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2C(=O)OCc2c1 InChI=1S/C24H22FN3O3/c25-21-10-14(13-4-6-20-17(7-13)12-31-24(20)30)1-2-15(21)8-19(11-26)28-23(29)22-16-3-5-18(9-16)27-22/h1-2,4,6-7,10,16,18-19,22,27H,3,5,8-9,12H2,(H,28,29)/t16-,18+,19?,22-/m0/s1 WTHQKFUPVXDWIU-AAEOLZRXSA-N 150337 US10238633, Example 11::US8987249, 11::US9713606, 11 Dipeptidyl peptidase 1 1.70 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150337 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150337&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430788 252824588 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500199 CS(=O)(=O)c1ccc(cc1F)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H23F2N3O3S/c1-32(30,31)21-7-5-14(11-20(21)25)13-2-3-15(19(24)10-13)8-18(12-26)28-23(29)22-16-4-6-17(9-16)27-22/h2-3,5,7,10-11,16-18,22,27H,4,6,8-9H2,1H3,(H,28,29)/t16-,17+,18-,22-/m0/s1 ZGJRMKDBJBZGHJ-SUWCGCSTSA-N 150338 US10238633, Example 12::US8987249, 12::US9713606, 12 Dipeptidyl peptidase 1 1.90 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150338 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150338&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430789 252824589 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500202 CN1C(=O)Cc2ccc(cc12)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C25H25FN4O2/c1-30-22-11-15(3-5-17(22)12-23(30)31)14-2-4-16(21(26)10-14)8-20(13-27)29-25(32)24-18-6-7-19(9-18)28-24/h2-5,10-11,18-20,24,28H,6-9,12H2,1H3,(H,29,32)/t18-,19+,20?,24-/m0/s1 MNEOBAAFLAQMKF-BQTZMPSMSA-N 150341 US10238633, Example 15::US8987249, 15::US9713606, 15 Dipeptidyl peptidase 1 2.00 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150341 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150341&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430760 252824592 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500203 CS(=O)(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H24FN3O3S/c1-31(29,30)20-8-5-14(6-9-20)15-2-3-16(21(24)12-15)10-19(13-25)27-23(28)22-17-4-7-18(11-17)26-22/h2-3,5-6,8-9,12,17-19,22,26H,4,7,10-11H2,1H3,(H,27,28)/t17-,18+,19-,22-/m0/s1 KKCIOVAGWAIFAX-WEMPKCCASA-N 150342 US10238633, Example 16::US8987249, 16::US9713606, 16 Dipeptidyl peptidase 1 2.60 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150342 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150342&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430804 252824593 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500204 COC(=O)c1cc(cs1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H22FN3O3S/c1-29-22(28)19-9-15(11-30-19)12-2-3-13(18(23)8-12)6-17(10-24)26-21(27)20-14-4-5-16(7-14)25-20/h2-3,8-9,11,14,16-17,20,25H,4-7H2,1H3,(H,26,27)/t14-,16+,17-,20-/m0/s1 QSEMIFYIVMRBGQ-FORWCCJISA-N 150343 US10238633, Example 17::US8987249, 17::US9713606, 17 Dipeptidyl peptidase 1 2.60 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150343 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150343&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430761 252824594 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500205 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccsc1 InChI=1S/C20H20FN3OS/c21-18-9-12(15-5-6-26-11-15)1-2-13(18)7-17(10-22)24-20(25)19-14-3-4-16(8-14)23-19/h1-2,5-6,9,11,14,16-17,19,23H,3-4,7-8H2,(H,24,25)/t14-,16+,17-,19-/m0/s1 CUGBXLAZKQOEHU-RUENVJTFSA-N 150344 US10238633, Example 18::US8987249, 18::US9713606, 18 Dipeptidyl peptidase 1 2.70 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150344 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150344&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430762 252824595 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500206 CS(=O)(=O)c1cc(ccc1C#N)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H23FN4O3S/c1-33(31,32)22-11-15(3-5-18(22)12-26)14-2-4-16(21(25)10-14)8-20(13-27)29-24(30)23-17-6-7-19(9-17)28-23/h2-5,10-11,17,19-20,23,28H,6-9H2,1H3,(H,29,30)/t17-,19+,20?,23-/m0/s1 AUHJWFLPELHPMB-GKUGZCSRSA-N 150345 US10238633, Example 19::US8987249, 19::US9713606, 19 Dipeptidyl peptidase 1 2.80 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150345&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443252 252824596 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500207 CC(=O)n1cc(cn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H22FN5O2/c1-12(28)27-11-16(10-24-27)13-2-3-14(19(22)8-13)6-18(9-23)26-21(29)20-15-4-5-17(7-15)25-20/h2-3,8,10-11,15,17-18,20,25H,4-7H2,1H3,(H,26,29)/t15-,17+,18-,20-/m0/s1 YGHKDCMFTPEJME-NFBUACBFSA-N 150346 US10238633, Example 20::US8987249, 20::US9713606, 20 Dipeptidyl peptidase 1 3.10 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150346 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150346&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443158 252824597 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500208 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnn(CC2CCOC2)c1 InChI=1S/C24H28FN5O2/c25-22-9-16(19-11-27-30(13-19)12-15-5-6-32-14-15)1-2-17(22)7-21(10-26)29-24(31)23-18-3-4-20(8-18)28-23/h1-2,9,11,13,15,18,20-21,23,28H,3-8,12,14H2,(H,29,31)/t15?,18-,20+,21-,23-/m0/s1 CWXBPKJABGXNSH-ZDOHZWEYSA-N 150347 US10238633, Example 21::US8987249, 21::US9713606, 21 Dipeptidyl peptidase 1 3.10 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150347 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150347&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430561 252824598 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500209 Fc1cc(ccc1CC(NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2CC(=O)Nc2c1 InChI=1S/C24H23FN4O2/c25-20-9-13(14-2-4-16-11-22(30)29-21(16)10-14)1-3-15(20)7-19(12-26)28-24(31)23-17-5-6-18(8-17)27-23/h1-4,9-10,17-19,23,27H,5-8,11H2,(H,28,31)(H,29,30)/t17-,18+,19?,23-/m0/s1 GRTBTBDXCOSHDK-UNEJAWRNSA-N 150348 US10238633, Example 22::US8987249, 22::US9713606, 22 Dipeptidyl peptidase 1 3.30 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150348 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150348&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430555 252824599 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500212 Cc1ncc(s1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C20H21FN4OS/c1-11-23-10-18(27-11)13-3-2-12(17(21)8-13)6-16(9-22)25-20(26)19-14-4-5-15(7-14)24-19/h2-3,8,10,14-16,19,24H,4-7H2,1H3,(H,25,26)/t14-,15+,16-,19-/m0/s1 SKTGXDCDCGNQOW-RCJHGTSTSA-N 150351 US10238633, Example 25::US8987249, 25::US9713606, 25 Dipeptidyl peptidase 1 3.90 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150351&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430587 252824602 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500213 CCn1cc(cn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H24FN5O/c1-2-27-12-16(11-24-27)13-3-4-14(19(22)9-13)7-18(10-23)26-21(28)20-15-5-6-17(8-15)25-20/h3-4,9,11-12,15,17-18,20,25H,2,5-8H2,1H3,(H,26,28)/t15-,17+,18-,20-/m0/s1 BOEDWXHZEWDSOJ-NFBUACBFSA-N 150352 US10238633, Example 26::US8987249, 26::US9713606, 26 Dipeptidyl peptidase 1 4.00 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150352 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150352&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430578 252824603 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500214 Cc1ccc(o1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H22FN3O2/c1-12-2-7-19(27-12)14-4-3-13(18(22)10-14)8-17(11-23)25-21(26)20-15-5-6-16(9-15)24-20/h2-4,7,10,15-17,20,24H,5-6,8-9H2,1H3,(H,25,26)/t15-,16+,17-,20-/m0/s1 WPUSIXGXCBPYHG-CLWJZODNSA-N 150353 US10238633, Example 27::US8987249, 27::US9713606, 27 Dipeptidyl peptidase 1 4.00 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150353 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150353&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430579 252824604 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500215 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnn(CC2CCCCO2)c1 InChI=1S/C25H30FN5O2/c26-23-11-16(19-13-28-31(14-19)15-22-3-1-2-8-33-22)4-5-17(23)9-21(12-27)30-25(32)24-18-6-7-20(10-18)29-24/h4-5,11,13-14,18,20-22,24,29H,1-3,6-10,15H2,(H,30,32)/t18-,20+,21-,22?,24-/m0/s1 SLLIUCDDDQLBAQ-MVUGTHIMSA-N 150354 US10238633, Example 28::US8987249, 28::US9713606, 28 Dipeptidyl peptidase 1 4.10 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150354 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150354&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430571 252824605 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500216 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2CC(=O)Nc2c1 InChI=1S/C24H23FN4O2/c25-20-9-13(14-2-4-16-11-22(30)29-21(16)10-14)1-3-15(20)7-19(12-26)28-24(31)23-17-5-6-18(8-17)27-23/h1-4,9-10,17-19,23,27H,5-8,11H2,(H,28,31)(H,29,30)/t17-,18+,19-,23-/m0/s1 GRTBTBDXCOSHDK-YWNPBTLJSA-N 150355 US10238633, Example 29::US8987249, 29::US9713606, 29 Dipeptidyl peptidase 1 4.20 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150355&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430677 252824606 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500217 CCCn1cc(cn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H26FN5O/c1-2-7-28-13-17(12-25-28)14-3-4-15(20(23)10-14)8-19(11-24)27-22(29)21-16-5-6-18(9-16)26-21/h3-4,10,12-13,16,18-19,21,26H,2,5-9H2,1H3,(H,27,29)/t16-,18+,19-,21-/m0/s1 LCAYDHNDEUNJEG-KRQVXIAISA-N 150356 US10238633, Example 30::US8987249, 30::US9713606, 30 Dipeptidyl peptidase 1 4.20 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150356 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150356&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430567 252824607 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500218 CN1C(=O)Cc2ccc(cc12)-c1cc(F)c(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1F InChI=1S/C25H24F2N4O2/c1-31-22-9-13(2-3-14(22)10-23(31)32)19-11-20(26)16(8-21(19)27)7-18(12-28)30-25(33)24-15-4-5-17(6-15)29-24/h2-3,8-9,11,15,17-18,24,29H,4-7,10H2,1H3,(H,30,33)/t15-,17+,18-,24-/m0/s1 JXOWBXXJEMLQAI-DAKPEJIASA-N 263602 US9713606, 31 Dipeptidyl peptidase 1 4.30 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263602&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118970717 377002506 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500219 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCN(CC1)c1ccccc1 InChI=1S/C26H30FN5O/c27-24-16-23(32-12-10-31(11-13-32)22-4-2-1-3-5-22)9-7-18(24)14-21(17-28)30-26(33)25-19-6-8-20(15-19)29-25/h1-5,7,9,16,19-21,25,29H,6,8,10-15H2,(H,30,33)/t19-,20+,21-,25-/m0/s1 FPIYYDMSEAXZFH-PDFGSZSQSA-N 150358 US10238633, Example 32::US8987249, 32::US9713606, 32 Dipeptidyl peptidase 1 4.50 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150358&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90415523 252824609 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500220 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc(s1)C(F)(F)F InChI=1S/C21H19F4N3OS/c22-16-9-12(17-5-6-18(30-17)21(23,24)25)2-1-11(16)7-15(10-26)28-20(29)19-13-3-4-14(8-13)27-19/h1-2,5-6,9,13-15,19,27H,3-4,7-8H2,(H,28,29)/t13-,14+,15-,19-/m0/s1 HRFVYBFWQMQWTD-YGTYGHESSA-N 150359 US10238633, Example 33::US8987249, 33::US9713606, 33 Dipeptidyl peptidase 1 4.50 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150359 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150359&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430300 252824610 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500223 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cccs1 InChI=1S/C20H20FN3OS/c21-17-10-13(18-2-1-7-26-18)4-3-12(17)8-16(11-22)24-20(25)19-14-5-6-15(9-14)23-19/h1-4,7,10,14-16,19,23H,5-6,8-9H2,(H,24,25)/t14-,15+,16-,19-/m0/s1 XFLYDHSZANAGSB-RCJHGTSTSA-N 150362 US10238633, Example 36::US8987249, 36::US9713606, 36 Dipeptidyl peptidase 1 4.70 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150362&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430301 252824613 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500224 NS(=O)(=O)c1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H23FN4O3S/c23-20-11-14(13-2-1-3-19(10-13)31(25,29)30)4-5-15(20)8-18(12-24)27-22(28)21-16-6-7-17(9-16)26-21/h1-5,10-11,16-18,21,26H,6-9H2,(H,27,28)(H2,25,29,30)/t16-,17+,18-,21-/m0/s1 YOUYIXZXGRAFJC-NYUBLWNDSA-N 263608 US9713606, 37 Dipeptidyl peptidase 1 4.70 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263608&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118970716 377002512 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500261 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnn(c1)C(=O)C1CCOCC1 InChI=1S/C25H28FN5O3/c26-22-11-16(19-13-28-31(14-19)25(33)15-5-7-34-8-6-15)1-2-17(22)9-21(12-27)30-24(32)23-18-3-4-20(10-18)29-23/h1-2,11,13-15,18,20-21,23,29H,3-10H2,(H,30,32)/t18-,20+,21-,23-/m0/s1 UAHSBFZVBPGAMM-SQMWVJLWSA-N 150400 US10238633, Example 74::US8987249, 74::US9713606, 74 Dipeptidyl peptidase 1 11.4 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150400 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150400&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443238 252824651 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500262 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccccc1 InChI=1S/C22H22FN3O/c23-20-12-15(14-4-2-1-3-5-14)6-7-16(20)10-19(13-24)26-22(27)21-17-8-9-18(11-17)25-21/h1-7,12,17-19,21,25H,8-11H2,(H,26,27)/t17-,18+,19-,21-/m0/s1 OIOPQZQMGBPXIP-JTJHWIPRSA-N 150401 US10238633, Example 75::US8987249, 75::US9713606, 75 Dipeptidyl peptidase 1 11.4 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150401 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150401&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430771 252824652 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500263 CN1Cc2cc(ccc2C1=O)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C25H25FN4O2/c1-30-13-18-8-14(5-7-21(18)25(30)32)15-2-3-16(22(26)11-15)9-20(12-27)29-24(31)23-17-4-6-19(10-17)28-23/h2-3,5,7-8,11,17,19-20,23,28H,4,6,9-10,13H2,1H3,(H,29,31)/t17-,19+,20?,23-/m0/s1 DYVYDWKPJKXISA-GKUGZCSRSA-N 150402 US10238633, Example 76::US8987249, 76::US9713606, 76 Dipeptidyl peptidase 1 11.7 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150402 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150402&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430726 252824653 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500264 COc1ccc(cc1OC)-c1cn(nn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C26H27FN6O3/c1-35-23-8-5-16(11-24(23)36-2)22-14-33(32-31-22)20-7-4-15(21(27)12-20)9-19(13-28)30-26(34)25-17-3-6-18(10-17)29-25/h4-5,7-8,11-12,14,17-19,25,29H,3,6,9-10H2,1-2H3,(H,30,34)/t17-,18+,19-,25-/m0/s1 OSHOVYZSVKRYIM-XMNZWCOLSA-N 150403 US10238633, Example 77::US8987249, 77::US9713606, 77 Dipeptidyl peptidase 1 11.9 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150403 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150403&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90440138 252824654 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500265 Fc1cc(ccc1CC(NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnn(c1)-c1ccccc1 InChI=1S/C25H24FN5O/c26-23-12-16(19-14-28-31(15-19)22-4-2-1-3-5-22)6-7-17(23)10-21(13-27)30-25(32)24-18-8-9-20(11-18)29-24/h1-7,12,14-15,18,20-21,24,29H,8-11H2,(H,30,32)/t18-,20+,21?,24-/m0/s1 DMZSQOLHWTVSKK-VVJUMWPSSA-N 150404 US10238633, Example 78::US8987249, 78::US9713606, 78 Dipeptidyl peptidase 1 12.0 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150404 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150404&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430773 252824655 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500266 Fc1cc(ccc1CC(NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2NC(=O)Cc2c1 InChI=1S/C24H23FN4O2/c25-20-10-14(13-4-6-21-17(7-13)11-22(30)29-21)1-2-15(20)8-19(12-26)28-24(31)23-16-3-5-18(9-16)27-23/h1-2,4,6-7,10,16,18-19,23,27H,3,5,8-9,11H2,(H,28,31)(H,29,30)/t16-,18+,19?,23-/m0/s1 CWSSERJVIIYICB-KLGBNGAQSA-N 150405 US10238633, Example 79::US8987249, 79::US9713606, 79 Dipeptidyl peptidase 1 12.0 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150405 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150405&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430606 252824656 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500267 Cc1nc(C)c(s1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H23FN4OS/c1-11-20(28-12(2)24-11)15-4-3-13(18(22)9-15)7-17(10-23)26-21(27)19-14-5-6-16(8-14)25-19/h3-4,9,14,16-17,19,25H,5-8H2,1-2H3,(H,26,27)/t14-,16+,17-,19-/m0/s1 BHLVXHBFLZCTGC-RUENVJTFSA-N 150406 US10238633, Example 80::US8987249, 80::US9713606, 80 Dipeptidyl peptidase 1 12.4 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150406 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150406&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430622 252824657 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500268 CN1C(=O)Cc2ccc(cc12)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(Cl)c1 InChI=1S/C25H25ClN4O2/c1-30-22-11-15(3-5-17(22)12-23(30)31)14-2-4-16(21(26)10-14)8-20(13-27)29-25(32)24-18-6-7-19(9-18)28-24/h2-5,10-11,18-20,24,28H,6-9,12H2,1H3,(H,29,32)/t18-,19+,20?,24-/m0/s1 GNKBVILCETUBCX-BQTZMPSMSA-N 150407 US8987249, 81::US9713606, 81 Dipeptidyl peptidase 1 13.1 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150407 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150407&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430607 252824658 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500269 CCC(C)(O)Cc1cn(nn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H29FN6O2/c1-3-23(2,32)11-18-13-30(29-28-18)19-7-5-14(20(24)10-19)8-17(12-25)27-22(31)21-15-4-6-16(9-15)26-21/h5,7,10,13,15-17,21,26,32H,3-4,6,8-9,11H2,1-2H3,(H,27,31)/t15-,16+,17-,21-,23?/m0/s1 VWKCUYRNWHGYTG-GHBDIUCWSA-N 150408 US10238633, Example 82::US8987249, 82::US9713606, 82 Dipeptidyl peptidase 1 13.1 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150408 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150408&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430623 252824659 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500270 NC(=O)c1ccc(cc1)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H23FN4O2/c24-20-11-15(13-1-3-14(4-2-13)22(26)29)5-6-16(20)9-19(12-25)28-23(30)21-17-7-8-18(10-17)27-21/h1-6,11,17-19,21,27H,7-10H2,(H2,26,29)(H,28,30)/t17-,18+,19?,21-/m0/s1 NQZMPJPNGZQKNA-VHRCFOOQSA-N 150409 US10238633, Example 83::US8987249, 83::US9713606, 83 Dipeptidyl peptidase 1 13.3 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150409 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150409&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430624 252824660 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500271 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-n1cc(nn1)-c1ccc2occc2c1 InChI=1S/C26H23FN6O2/c27-22-12-21(33-14-23(31-32-33)16-3-6-24-17(9-16)7-8-35-24)5-2-15(22)10-20(13-28)30-26(34)25-18-1-4-19(11-18)29-25/h2-3,5-9,12,14,18-20,25,29H,1,4,10-11H2,(H,30,34)/t18-,19+,20-,25-/m0/s1 RGXUCUBHDNKLOH-ZDQHKECQSA-N 150410 US10238633, Example 84::US8987249, 84::US9713606, 84 Dipeptidyl peptidase 1 13.7 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150410 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150410&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430617 252824661 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500272 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccsc1C#N InChI=1S/C21H19FN4OS/c22-18-9-12(17-5-6-28-19(17)11-24)1-2-13(18)7-16(10-23)26-21(27)20-14-3-4-15(8-14)25-20/h1-2,5-6,9,14-16,20,25H,3-4,7-8H2,(H,26,27)/t14-,15+,16-,20-/m0/s1 JBFGXPGASYJVIZ-QOIOWGMHSA-N 150411 US10238633, Example 85::US8987249, 85::US9713606, 85 Dipeptidyl peptidase 1 14.0 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150411 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150411&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430798 252824662 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500273 CS(=O)(=O)c1ccc(c(F)c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H23F2N3O3S/c1-32(30,31)18-6-7-19(21(25)11-18)13-2-3-14(20(24)10-13)8-17(12-26)28-23(29)22-15-4-5-16(9-15)27-22/h2-3,6-7,10-11,15-17,22,27H,4-5,8-9H2,1H3,(H,28,29)/t15-,16+,17-,22-/m0/s1 OPAJMLXYCWWNLW-GEYWLOKFSA-N 150412 US10238633, Example 86::US8987249, 86::US9713606, 86 Dipeptidyl peptidase 1 14.1 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150412 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150412&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430868 252824663 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500274 COCC(=O)n1cc(cn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H24FN5O3/c1-31-12-20(29)28-11-16(10-25-28)13-2-3-14(19(23)8-13)6-18(9-24)27-22(30)21-15-4-5-17(7-15)26-21/h2-3,8,10-11,15,17-18,21,26H,4-7,12H2,1H3,(H,27,30)/t15-,17+,18-,21-/m0/s1 SCGDLXUAKULUFJ-DKXUYOFUSA-N 150413 US10238633, Example 87::US8987249, 87::US9713606, 87 Dipeptidyl peptidase 1 14.2 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150413 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150413&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443239 252824664 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500275 CS(=O)(=O)c1cccc(c1)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H24FN3O3S/c1-31(29,30)20-4-2-3-14(11-20)15-5-6-16(21(24)12-15)9-19(13-25)27-23(28)22-17-7-8-18(10-17)26-22/h2-6,11-12,17-19,22,26H,7-10H2,1H3,(H,27,28)/t17-,18+,19?,22-/m0/s1 SLANNUBDKTXJNP-HJKBJPMPSA-N 150414 US10238633, Example 88::US8987249, 88::US9713606, 88 Dipeptidyl peptidase 1 15.2 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150414 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150414&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430806 252824665 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500276 CCC(O)Cc1cn(nn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H27FN6O2/c1-2-19(30)9-17-12-29(28-27-17)18-6-4-13(20(23)10-18)7-16(11-24)26-22(31)21-14-3-5-15(8-14)25-21/h4,6,10,12,14-16,19,21,25,30H,2-3,5,7-9H2,1H3,(H,26,31)/t14-,15+,16-,19?,21-/m0/s1 QBYQWVRYHRNFFO-NUDGSJNLSA-N 150415 US10238633, Example 89::US8987249, 89::US9713606, 89 Dipeptidyl peptidase 1 15.6 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150415&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430796 252824666 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500277 CC(=O)c1cn(nn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C20H21FN6O2/c1-11(28)18-10-27(26-25-18)16-5-3-12(17(21)8-16)6-15(9-22)24-20(29)19-13-2-4-14(7-13)23-19/h3,5,8,10,13-15,19,23H,2,4,6-7H2,1H3,(H,24,29)/t13-,14+,15-,19-/m0/s1 JCEDMPSWCYIJPG-YGTYGHESSA-N 150416 US10238633, Example 90::US8987249, 90::US9713606, 90 Dipeptidyl peptidase 1 16.0 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150416 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150416&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430807 252824667 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500278 CS(=O)(=O)N1CCN(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H28FN5O3S/c1-31(29,30)27-8-6-26(7-9-27)18-5-3-14(19(22)12-18)10-17(13-23)25-21(28)20-15-2-4-16(11-15)24-20/h3,5,12,15-17,20,24H,2,4,6-11H2,1H3,(H,25,28)/t15-,16+,17-,20-/m0/s1 YKWPCSVFBUCYCD-CLWJZODNSA-N 150417 US10238633, Example 91::US8987249, 91::US9713606, 91 Dipeptidyl peptidase 1 17.0 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150417 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150417&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430749 252824668 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500279 Cc1oncc1-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C20H21FN4O2/c1-11-17(10-23-27-11)12-2-3-13(18(21)8-12)6-16(9-22)25-20(26)19-14-4-5-15(7-14)24-19/h2-3,8,10,14-16,19,24H,4-7H2,1H3,(H,25,26)/t14-,15+,16?,19-/m0/s1 NTCIALRELKXPAF-IEBWDACRSA-N 263663 US9713606, 92 Dipeptidyl peptidase 1 17.7 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263663 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263663&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118966876 377002566 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500280 Cc1ncc(s1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C21H21FN4OS/c1-10-24-9-19(28-10)12-3-2-11(17(22)5-12)4-13(8-23)25-21(27)20-16-7-18(26-20)15-6-14(15)16/h2-3,5,9,13-16,18,20,26H,4,6-7H2,1H3,(H,25,27)/t13-,14+,15-,16+,18-,20-/m0/s1 XTPZCJCPIUDBMC-SHIIKYBRSA-N 150419 US10238633, Example 93::US8987249, 93::US9713606, 93 Dipeptidyl peptidase 1 18.3 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150419 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150419&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430767 252824670 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500281 COc1cccc(c1)-c1cn(nn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C25H25FN6O2/c1-34-21-4-2-3-16(11-21)23-14-32(31-30-23)20-8-6-15(22(26)12-20)9-19(13-27)29-25(33)24-17-5-7-18(10-17)28-24/h2-4,6,8,11-12,14,17-19,24,28H,5,7,9-10H2,1H3,(H,29,33)/t17-,18+,19-,24-/m0/s1 BVKSOIQSAWREHK-YDLHNXBPSA-N 150420 US10238633, Example 94::US8987249, 94::US9713606, 94 Dipeptidyl peptidase 1 18.7 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150420 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150420&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430792 252824671 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500282 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2CNC(=O)c2c1 InChI=1S/C24H23FN4O2/c25-21-10-14(13-2-4-17-12-27-23(30)20(17)9-13)1-3-15(21)7-19(11-26)29-24(31)22-16-5-6-18(8-16)28-22/h1-4,9-10,16,18-19,22,28H,5-8,12H2,(H,27,30)(H,29,31)/t16-,18+,19-,22-/m0/s1 YVPAYTOMTQVUAC-ZBPHCFQXSA-N 150421 US10238633, Example 95::US8987249, 95::US9713606, 95 Dipeptidyl peptidase 1 19.2 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150421 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150421&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430778 252824672 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500283 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cc(no1)-c1ccccc1 InChI=1S/C25H23FN4O2/c26-21-12-17(23-13-22(30-32-23)15-4-2-1-3-5-15)7-6-16(21)10-20(14-27)29-25(31)24-18-8-9-19(11-18)28-24/h1-7,12-13,18-20,24,28H,8-11H2,(H,29,31)/t18-,19+,20-,24-/m0/s1 QESWGIWAZDKMDD-VKDGWMQASA-N 150422 US10238633, Example 96::US8987249, 96::US9713606, 96 Dipeptidyl peptidase 1 19.8 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150422 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150422&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430750 252824673 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500284 COCCn1cc(cn1)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H26FN5O2/c1-30-7-6-28-13-17(12-25-28)14-2-3-15(20(23)10-14)8-19(11-24)27-22(29)21-16-4-5-18(9-16)26-21/h2-3,10,12-13,16,18-19,21,26H,4-9H2,1H3,(H,27,29)/t16-,18+,19?,21-/m0/s1 IQMJMZXJSJWJBP-PLPRGGQXSA-N 150423 US10238633, Example 97::US8987249, 97::US9713606, 97 Dipeptidyl peptidase 1 19.9 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150423 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150423&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430842 252824674 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500285 Fc1cc(ccc1CC(NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ncc(Cl)cn1 InChI=1S/C20H19ClFN5O/c21-14-9-24-19(25-10-14)13-2-1-11(17(22)7-13)5-16(8-23)27-20(28)18-12-3-4-15(6-12)26-18/h1-2,7,9-10,12,15-16,18,26H,3-6H2,(H,27,28)/t12-,15+,16?,18-/m0/s1 AKPGVXYITPFJOW-UDOSGHBDSA-N 150424 US10238633, Example 98::US8987249, 98::US9713606, 98 Dipeptidyl peptidase 1 20.3 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150424 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150424&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430870 252824675 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500286 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-n1cc(CCN2CCOCC2)nn1 InChI=1S/C24H30FN7O2/c25-22-13-21(32-15-19(29-30-32)5-6-31-7-9-34-10-8-31)4-2-16(22)11-20(14-26)28-24(33)23-17-1-3-18(12-17)27-23/h2,4,13,15,17-18,20,23,27H,1,3,5-12H2,(H,28,33)/t17-,18+,20-,23-/m0/s1 MYILWBBNYUAXDA-KQZHTCIUSA-N 150425 US10238633, Example 99::US8987249, 99::US9713606, 99 Dipeptidyl peptidase 1 21.1 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150425 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150425&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937191 252824676 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500287 Cn1nc(cc1-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1)C(F)(F)F InChI=1S/C21H21F4N5O/c1-30-17(9-18(29-30)21(23,24)25)12-3-2-11(16(22)8-12)6-15(10-26)28-20(31)19-13-4-5-14(7-13)27-19/h2-3,8-9,13-15,19,27H,4-7H2,1H3,(H,28,31)/t13-,14+,15-,19-/m0/s1 MYYLJSMDWKTSJL-YGTYGHESSA-N 150426 US10238633, Example 100::US8987249, 100::US9713606, 100 Dipeptidyl peptidase 1 22.3 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150426 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150426&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430809 252824677 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500288 CC(O)Cc1cn(nn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H25FN6O2/c1-12(29)6-17-11-28(27-26-17)18-5-3-13(19(22)9-18)7-16(10-23)25-21(30)20-14-2-4-15(8-14)24-20/h3,5,9,11-12,14-16,20,24,29H,2,4,6-8H2,1H3,(H,25,30)/t12?,14-,15+,16-,20-/m0/s1 CMGDKMRQSURTJI-VPRMXFSVSA-N 150427 US10238633, Example 101::US8987249, 101::US9713606, 101 Dipeptidyl peptidase 1 23.9 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150427 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150427&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430871 252824678 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500289 Fc1cc(ccc1CC(NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnc(Cl)cn1 InChI=1S/C20H19ClFN5O/c21-18-10-24-17(9-25-18)12-2-1-11(16(22)7-12)5-15(8-23)27-20(28)19-13-3-4-14(6-13)26-19/h1-2,7,9-10,13-15,19,26H,3-6H2,(H,27,28)/t13-,14+,15?,19-/m0/s1 JGOVHYJPZVPVCA-FKGKKHCZSA-N 150428 US10238633, Example 102::US8987249, 102::US9713606, 102 Dipeptidyl peptidase 1 24.8 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150428 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150428&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430843 252824679 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500290 Fc1cc(ccc1CC(NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccoc1 InChI=1S/C20H20FN3O2/c21-18-9-12(15-5-6-26-11-15)1-2-13(18)7-17(10-22)24-20(25)19-14-3-4-16(8-14)23-19/h1-2,5-6,9,11,14,16-17,19,23H,3-4,7-8H2,(H,24,25)/t14-,16+,17?,19-/m0/s1 BNIARBLPIAJFIM-QSBFGILCSA-N 150429 US10238633, Example 103::US8987249, 103::US9713606, 103 Dipeptidyl peptidase 1 24.9 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150429 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150429&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430384 252824680 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500291 Cc1n[nH]cc1-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 150430 US10238633, Example 104::US8987249, 104::US9713606, 104 Dipeptidyl peptidase 1 24.9 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150430 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150430&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430365 252824681 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500292 CCOCc1cn(nn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H25FN6O2/c1-2-30-12-17-11-28(27-26-17)18-6-4-13(19(22)9-18)7-16(10-23)25-21(29)20-14-3-5-15(8-14)24-20/h4,6,9,11,14-16,20,24H,2-3,5,7-8,12H2,1H3,(H,25,29)/t14-,15+,16-,20-/m0/s1 ABSBTIIBDKCMEG-QOIOWGMHSA-N 150431 US10238633, Example 105::US8987249, 105::US9713606, 105 Dipeptidyl peptidase 1 25.0 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150431 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150431&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430366 252824682 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500293 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-n1cc(COC(=O)N2CCCC2)nn1 InChI=1S/C24H28FN7O3/c25-21-11-20(32-13-19(29-30-32)14-35-24(34)31-7-1-2-8-31)6-4-15(21)9-18(12-26)28-23(33)22-16-3-5-17(10-16)27-22/h4,6,11,13,16-18,22,27H,1-3,5,7-10,14H2,(H,28,33)/t16-,17+,18-,22-/m0/s1 SCQBGLUSDQKNSV-SUWCGCSTSA-N 150432 US10238633, Example 106::US8987249, 106::US9713606, 106 Dipeptidyl peptidase 1 25.9 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150432&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430334 252824683 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500294 Cn1c2ccc(cc2oc1=O)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H23FN4O3/c1-29-20-7-5-14(11-21(20)32-24(29)31)13-2-3-15(19(25)10-13)8-18(12-26)28-23(30)22-16-4-6-17(9-16)27-22/h2-3,5,7,10-11,16-18,22,27H,4,6,8-9H2,1H3,(H,28,30)/t16-,17+,18?,22-/m0/s1 HSOUISMKPAKWDA-QOPFVKLFSA-N 150433 US10238633, Example 107::US8987249, 107::US9713606, 107 Dipeptidyl peptidase 1 25.9 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150433 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150433&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430367 252824684 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500239 CS(=O)(=O)c1cc(ccc1C#N)-c1cc(F)c(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H22F2N4O3S/c1-34(32,33)22-9-13(2-3-15(22)11-27)16-7-20(25)19(21(26)8-16)10-18(12-28)30-24(31)23-14-4-5-17(6-14)29-23/h2-3,7-9,14,17-18,23,29H,4-6,10H2,1H3,(H,30,31)/t14-,17+,18?,23-/m0/s1 APWWFYPMQQAZJM-JRRJEJKYSA-N 150378 US10238633, Example 52::US8987249, 52::US9713606, 52 Dipeptidyl peptidase 1 7.60 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150378 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150378&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430599 252824629 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500236 Fc1cc(ccc1CC(NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2C(=O)NCCc2c1 InChI=1S/C25H25FN4O2/c26-22-12-15(14-4-6-21-16(9-14)7-8-28-24(21)31)1-2-17(22)10-20(13-27)30-25(32)23-18-3-5-19(11-18)29-23/h1-2,4,6,9,12,18-20,23,29H,3,5,7-8,10-11H2,(H,28,31)(H,30,32)/t18-,19+,20?,23-/m0/s1 GEDCUYAXKGCEAP-SRDOODBNSA-N 150375 US10238633, Example 49::US8987249, 49::US9713606, 49 Dipeptidyl peptidase 1 7.30 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150375 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150375&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430681 252824626 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500237 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnn(CC2CCCO2)c1 InChI=1S/C24H28FN5O2/c25-22-10-15(18-12-27-30(13-18)14-21-2-1-7-32-21)3-4-16(22)8-20(11-26)29-24(31)23-17-5-6-19(9-17)28-23/h3-4,10,12-13,17,19-21,23,28H,1-2,5-9,14H2,(H,29,31)/t17-,19+,20-,21?,23-/m0/s1 HMZMPMLDAMDPBI-XHISBUKVSA-N 150376 US10238633, Example 50::US8987249, 50::US9713606, 50 Dipeptidyl peptidase 1 7.40 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150376 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150376&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430682 252824627 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500238 CNS(=O)(=O)c1ccc(cc1)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H25FN4O3S/c1-26-32(30,31)20-8-5-14(6-9-20)15-2-3-16(21(24)12-15)10-19(13-25)28-23(29)22-17-4-7-18(11-17)27-22/h2-3,5-6,8-9,12,17-19,22,26-27H,4,7,10-11H2,1H3,(H,28,29)/t17-,18+,19?,22-/m0/s1 YCLHWAIRELKEQO-HJKBJPMPSA-N 150377 US10238633, Example 51::US8987249, 51::US9713606, 51 Dipeptidyl peptidase 1 7.50 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150377 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150377&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430653 252824628 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500240 NC(=O)c1cccc(c1)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H23FN4O2/c24-20-11-14(13-2-1-3-17(8-13)22(26)29)4-5-15(20)9-19(12-25)28-23(30)21-16-6-7-18(10-16)27-21/h1-5,8,11,16,18-19,21,27H,6-7,9-10H2,(H2,26,29)(H,28,30)/t16-,18+,19?,21-/m0/s1 URKPBBPYGGQLCL-PLPRGGQXSA-N 150379 US10238633, Example 53::US8987249, 53::US9713606, 53 Dipeptidyl peptidase 1 7.90 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150379 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150379&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430609 252824630 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500241 CS(=O)(=O)c1ccc(cc1)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H24FN3O3S/c1-31(29,30)20-8-5-14(6-9-20)15-2-3-16(21(24)12-15)10-19(13-25)27-23(28)22-17-4-7-18(11-17)26-22/h2-3,5-6,8-9,12,17-19,22,26H,4,7,10-11H2,1H3,(H,27,28)/t17-,18+,19?,22-/m0/s1 KKCIOVAGWAIFAX-HJKBJPMPSA-N 150380 US10238633, Example 54::US8987249, 54::US9713606, 54 Dipeptidyl peptidase 1 8.20 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150380 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150380&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430765 252824631 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500242 CC(=O)N1CCC(Cn2cc(cn2)-c2ccc(C[C@H](NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)c(F)c2)CC1 InChI=1S/C27H33FN6O2/c1-17(35)33-8-6-18(7-9-33)15-34-16-22(14-30-34)19-2-3-20(25(28)12-19)10-24(13-29)32-27(36)26-21-4-5-23(11-21)31-26/h2-3,12,14,16,18,21,23-24,26,31H,4-11,15H2,1H3,(H,32,36)/t21-,23+,24-,26-/m0/s1 BIHZNSYCANDRTI-YUZJIJRXSA-N 150381 US10238633, Example 55::US8987249, 55::US9713606, 55 Dipeptidyl peptidase 1 8.20 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150381 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150381&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430715 252824632 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500243 NS(=O)(=O)c1ccc(cc1)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H23FN4O3S/c23-20-11-14(13-4-7-19(8-5-13)31(25,29)30)1-2-15(20)9-18(12-24)27-22(28)21-16-3-6-17(10-16)26-21/h1-2,4-5,7-8,11,16-18,21,26H,3,6,9-10H2,(H,27,28)(H2,25,29,30)/t16-,17+,18?,21-/m0/s1 JPKDSNDSOPINLH-APZTZJSISA-N 150382 US10238633, Example 56::US8987249, 56::US9713606, 56 Dipeptidyl peptidase 1 8.30 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150382 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150382&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430748 252824633 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500244 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnn(CC2CCOCC2)c1 InChI=1S/C25H30FN5O2/c26-23-11-17(20-13-28-31(15-20)14-16-5-7-33-8-6-16)1-2-18(23)9-22(12-27)30-25(32)24-19-3-4-21(10-19)29-24/h1-2,11,13,15-16,19,21-22,24,29H,3-10,14H2,(H,30,32)/t19-,21+,22-,24-/m0/s1 DONGIUVRNSCBKX-OHCHIEETSA-N 150383 US10238633, Example 57::US8987249, 57::US9713606, 57 Dipeptidyl peptidase 1 8.30 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150383 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150383&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430727 252824634 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500245 Cc1cc(n[nH]1)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 150384 US10238633, Example 58::US8987249, 58::US9713606, 58 Dipeptidyl peptidase 1 8.40 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150384 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150384&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430774 252824635 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500246 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnc(s1)N1CCOCC1 InChI=1S/C23H26FN5O2S/c24-19-11-15(20-13-26-23(32-20)29-5-7-31-8-6-29)2-1-14(19)9-18(12-25)28-22(30)21-16-3-4-17(10-16)27-21/h1-2,11,13,16-18,21,27H,3-10H2,(H,28,30)/t16-,17+,18-,21-/m0/s1 VBXNUQLHVDGVOH-NYUBLWNDSA-N 150385 US10238633, Example 59::US8987249, 59::US9713606, 59 Dipeptidyl peptidase 1 8.50 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150385 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150385&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430869 252824636 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500247 Cn1nc2ccccc2c1-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H24FN5O/c1-30-23(19-4-2-3-5-21(19)29-30)16-7-6-14(20(25)12-16)10-18(13-26)28-24(31)22-15-8-9-17(11-15)27-22/h2-7,12,15,17-18,22,27H,8-11H2,1H3,(H,28,31)/t15-,17+,18-,22-/m0/s1 JXCFAQSIBMJFEG-PBWVOLNLSA-N 150386 US10238633, Example 60::US8987249, 60::US9713606, 60 Dipeptidyl peptidase 1 8.70 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150386 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150386&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430799 252824637 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500248 CN1C(=O)Cc2ccc(cc12)-c1cc(F)c(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C25H24F2N4O2/c1-31-22-9-13(2-3-14(22)10-23(31)32)16-7-20(26)19(21(27)8-16)11-18(12-28)30-25(33)24-15-4-5-17(6-15)29-24/h2-3,7-9,15,17-18,24,29H,4-6,10-11H2,1H3,(H,30,33)/t15-,17+,18?,24-/m0/s1 YIKYGCSOAIKXDX-GUZYLCRVSA-N 150387 US10238633, Example 61::US8987249, 61::US9713606, 61 Dipeptidyl peptidase 1 8.70 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150387 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150387&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430800 252824638 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500249 CS(=O)(=O)Nc1ccc(cc1)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H25FN4O3S/c1-32(30,31)28-18-7-4-14(5-8-18)15-2-3-16(21(24)12-15)10-20(13-25)27-23(29)22-17-6-9-19(11-17)26-22/h2-5,7-8,12,17,19-20,22,26,28H,6,9-11H2,1H3,(H,27,29)/t17-,19+,20?,22-/m0/s1 VTAUSOLFMBFCJS-FGODIZBMSA-N 150388 US10238633, Example 62::US8987249, 62::US9713606, 62 Dipeptidyl peptidase 1 9.10 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150388 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150388&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430768 252824639 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500250 CN1C=[N](C)C=C1c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H25FN5O/c1-26-11-19(27(2)12-26)14-4-3-13(18(22)9-14)7-17(10-23)25-21(28)20-15-5-6-16(8-15)24-20/h3-4,9,11-12,15-17,20,24H,5-8H2,1-2H3,(H,25,28)/t15-,16+,17-,20-/m0/s1 KVAABQFKGRIIMS-CLWJZODNSA-N 263634 US9713606, 63 Dipeptidyl peptidase 1 9.30 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263634 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263634&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 135120971 377002537 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500251 CC(C)Cn1cc(cn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H28FN5O/c1-14(2)12-29-13-18(11-26-29)15-3-4-16(21(24)9-15)7-20(10-25)28-23(30)22-17-5-6-19(8-17)27-22/h3-4,9,11,13-14,17,19-20,22,27H,5-8,12H2,1-2H3,(H,28,30)/t17-,19+,20-,22-/m0/s1 QNSCLBGDVKDDPO-UFGBVDADSA-N 150390 US10238633, Example 64::US8987249, 64::US9713606, 64 Dipeptidyl peptidase 1 9.30 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150390&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430841 252824641 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500252 Cc1c(cnn1C)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H24FN5O/c1-12-18(11-24-27(12)2)13-3-4-14(19(22)9-13)7-17(10-23)26-21(28)20-15-5-6-16(8-15)25-20/h3-4,9,11,15-17,20,25H,5-8H2,1-2H3,(H,26,28)/t15-,16+,17-,20-/m0/s1 BXMGRZWIJVZYAS-CLWJZODNSA-N 150365 US10238633, Example 39::US8987249, 39::US9713606, 65 Dipeptidyl peptidase 1 9.40 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150365 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150365&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430769 252824616 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500253 COc1ncc(cn1)-c1cn(nn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H23FN8O2/c1-34-23-26-10-15(11-27-23)20-12-32(31-30-20)18-5-3-13(19(24)8-18)6-17(9-25)29-22(33)21-14-2-4-16(7-14)28-21/h3,5,8,10-12,14,16-17,21,28H,2,4,6-7H2,1H3,(H,29,33)/t14-,16+,17-,21-/m0/s1 VYKOEQWAFLBCMG-CCFTVXDOSA-N 150392 US10238633, Example 66::US8987249, 66::US9713606, 66 Dipeptidyl peptidase 1 9.40 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150392 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150392&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937190 252824643 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500254 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-n1cc(nn1)C1CC1 InChI=1S/C21H23FN6O/c22-18-9-17(28-11-19(26-27-28)12-1-2-12)6-4-13(18)7-16(10-23)25-21(29)20-14-3-5-15(8-14)24-20/h4,6,9,11-12,14-16,20,24H,1-3,5,7-8H2,(H,25,29)/t14-,15+,16-,20-/m0/s1 XTPKWAUGRBRSMG-QOIOWGMHSA-N 150393 US10238633, Example 67::US8987249, 67::US9713606, 67 Dipeptidyl peptidase 1 9.60 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150393&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430347 252824644 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500255 CC(C)n1cc(cn1)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H26FN5O/c1-13(2)28-12-17(11-25-28)14-3-4-15(20(23)9-14)7-19(10-24)27-22(29)21-16-5-6-18(8-16)26-21/h3-4,9,11-13,16,18-19,21,26H,5-8H2,1-2H3,(H,27,29)/t16-,18+,19?,21-/m0/s1 KPULTUVWNZBBGM-PLPRGGQXSA-N 150394 US10238633, Example 68::US8987249, 68::US9713606, 68 Dipeptidyl peptidase 1 9.70 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150394&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430348 252824645 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500256 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cn[nH]c1 150395 US10238633, Example 69::US8987249, 69::US9713606, 69 Dipeptidyl peptidase 1 9.90 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150395 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150395&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430323 252824646 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500257 Cn1ncc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C25H24FN5O/c1-31-23-8-14(3-5-16(23)12-28-31)13-2-4-15(21(26)7-13)6-17(11-27)29-25(32)24-20-10-22(30-24)19-9-18(19)20/h2-5,7-8,12,17-20,22,24,30H,6,9-10H2,1H3,(H,29,32)/t17-,18+,19-,20+,22-,24-/m0/s1 QMOYISFVVPPPHT-BMSLZKTOSA-N 150396 US10238633, Example 70::US8987249, 70::US9713606, 70 Dipeptidyl peptidase 1 10.2 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150396 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150396&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430339 252824647 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500258 CCS(=O)(=O)c1ccc(cc1)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H26FN3O3S/c1-2-32(30,31)21-9-6-15(7-10-21)16-3-4-17(22(25)13-16)11-20(14-26)28-24(29)23-18-5-8-19(12-18)27-23/h3-4,6-7,9-10,13,18-20,23,27H,2,5,8,11-12H2,1H3,(H,28,29)/t18-,19+,20?,23-/m0/s1 AERARGOGTDRUGZ-SRDOODBNSA-N 150397 US10238633, Example 71::US8987249, 71::US9713606, 71 Dipeptidyl peptidase 1 10.8 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150397 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150397&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430349 252824648 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500259 CC(=O)c1ccc(s1)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H22FN3O2S/c1-12(27)19-6-7-20(29-19)14-3-2-13(18(23)10-14)8-17(11-24)26-22(28)21-15-4-5-16(9-15)25-21/h2-3,6-7,10,15-17,21,25H,4-5,8-9H2,1H3,(H,26,28)/t15-,16+,17?,21-/m0/s1 RBPTYWDZURRUTK-KWRFEPJMSA-N 150398 US10238633, Example 72::US8987249, 72::US9713606, 72 Dipeptidyl peptidase 1 10.8 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150398&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430316 252824649 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500260 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccco1 InChI=1S/C20H20FN3O2/c21-17-10-13(18-2-1-7-26-18)4-3-12(17)8-16(11-22)24-20(25)19-14-5-6-15(9-14)23-19/h1-4,7,10,14-16,19,23H,5-6,8-9H2,(H,24,25)/t14-,15+,16-,19-/m0/s1 XSWSPBCODWKSAB-RCJHGTSTSA-N 150399 US10238633, Example 73::US8987249, 73::US9713606, 73 Dipeptidyl peptidase 1 11.2 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150399 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150399&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430737 252824650 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500295 Fc1cc(ccc1CC(NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc(Cl)nn1 InChI=1S/C20H19ClFN5O/c21-18-6-5-17(26-27-18)12-2-1-11(16(22)9-12)7-15(10-23)25-20(28)19-13-3-4-14(8-13)24-19/h1-2,5-6,9,13-15,19,24H,3-4,7-8H2,(H,25,28)/t13-,14+,15?,19-/m0/s1 HEBPAARTHZGYLM-FKGKKHCZSA-N 150434 US10238633, Example 108::US8987249, 108::US9713606, 108 Dipeptidyl peptidase 1 26.4 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150434 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150434&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430436 252824685 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500296 CC(C)C(O)Cc1cn(nn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H29FN6O2/c1-13(2)21(31)9-18-12-30(29-28-18)19-6-4-14(20(24)10-19)7-17(11-25)27-23(32)22-15-3-5-16(8-15)26-22/h4,6,10,12-13,15-17,21-22,26,31H,3,5,7-9H2,1-2H3,(H,27,32)/t15-,16+,17-,21?,22-/m0/s1 WYCZQJCBELHBNC-UBQHZJADSA-N 150435 US10238633, Example 109::US8987249, 109::US9713606, 109 Dipeptidyl peptidase 1 26.9 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150435 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150435&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430391 252824686 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500297 CCn1nccc1-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H24FN5O/c1-2-27-19(7-8-24-27)14-4-3-13(18(22)11-14)9-17(12-23)26-21(28)20-15-5-6-16(10-15)25-20/h3-4,7-8,11,15-17,20,25H,2,5-6,9-10H2,1H3,(H,26,28)/t15-,16+,17-,20-/m0/s1 IHPAWNTVVZQHFV-CLWJZODNSA-N 150436 US10238633, Example 110::US8987249, 110::US9713606, 110 Dipeptidyl peptidase 1 28.6 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150436 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150436&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430785 252824687 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500298 COCc1cn(nn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C20H23FN6O2/c1-29-11-16-10-27(26-25-16)17-5-3-12(18(21)8-17)6-15(9-22)24-20(28)19-13-2-4-14(7-13)23-19/h3,5,8,10,13-15,19,23H,2,4,6-7,11H2,1H3,(H,24,28)/t13-,14+,15-,19-/m0/s1 YUYZMIRSJWARNU-YGTYGHESSA-N 150437 US10238633, Example 111::US8987249, 111::US9713606, 111 Dipeptidyl peptidase 1 31.8 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150437 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150437&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430786 252824688 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500299 COCCOCc1cn(nn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H27FN6O3/c1-31-6-7-32-13-18-12-29(28-27-18)19-5-3-14(20(23)10-19)8-17(11-24)26-22(30)21-15-2-4-16(9-15)25-21/h3,5,10,12,15-17,21,25H,2,4,6-9,13H2,1H3,(H,26,30)/t15-,16+,17-,21-/m0/s1 ZUVPKRLLJRNURX-DLRJPAPCSA-N 150438 US10238633, Example 112::US8987249, 112::US9713606, 112 Dipeptidyl peptidase 1 33.3 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150438 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150438&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90440140 252824689 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500300 CCc1ncc(s1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C22H23FN4OS/c1-2-20-25-10-19(29-20)12-4-3-11(17(23)6-12)5-13(9-24)26-22(28)21-16-8-18(27-21)15-7-14(15)16/h3-4,6,10,13-16,18,21,27H,2,5,7-8H2,1H3,(H,26,28)/t13-,14+,15-,16+,18-,21-/m0/s1 MBNDRKVILGAANK-OAXXGVFQSA-N 150439 US10238633, Example 113::US8987249, 113::US9713606, 113 Dipeptidyl peptidase 1 36.4 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150439 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150439&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430779 252824690 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500301 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cc[nH]n1 150440 US10238633, Example 114::US8987249, 114::US9713606, 114 Dipeptidyl peptidase 1 36.7 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150440 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150440&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430751 252824691 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500302 OC(=O)c1ccc(s1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H20FN3O3S/c22-16-9-12(17-5-6-18(29-17)21(27)28)2-1-11(16)7-15(10-23)25-20(26)19-13-3-4-14(8-13)24-19/h1-2,5-6,9,13-15,19,24H,3-4,7-8H2,(H,25,26)(H,27,28)/t13-,14+,15-,19-/m0/s1 UKXCOIVMRZGJFO-YGTYGHESSA-N 150441 US10238633, Example 115::US8987249, 115::US9713606, 115 Dipeptidyl peptidase 1 37.8 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150441&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430738 252824692 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500303 Fc1cc(ccc1CC(NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnn(c1)C1CCOCC1 InChI=1S/C24H28FN5O2/c25-22-11-15(18-13-27-30(14-18)21-5-7-32-8-6-21)1-2-16(22)9-20(12-26)29-24(31)23-17-3-4-19(10-17)28-23/h1-2,11,13-14,17,19-21,23,28H,3-10H2,(H,29,31)/t17-,19+,20?,23-/m0/s1 BPAHCPXZVBMFNE-GKUGZCSRSA-N 150442 US10238633, Example 116::US8987249, 116::US9713606, 116 Dipeptidyl peptidase 1 39.1 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150442 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150442&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430739 252824693 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500304 CN1CCC(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H29FN4O/c1-27-8-6-14(7-9-27)15-2-3-16(20(23)12-15)10-19(13-24)26-22(28)21-17-4-5-18(11-17)25-21/h2-3,12,14,17-19,21,25H,4-11H2,1H3,(H,26,28)/t17-,18+,19-,21-/m0/s1 HNBAKPJBZUSZLD-JTJHWIPRSA-N 150443 US10238633, Example 117::US8987249, 117::US9713606, 117 Dipeptidyl peptidase 1 39.6 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150443&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430745 252824694 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500305 Cn1cc(c(n1)C(F)(F)F)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H21F4N5O/c1-30-10-16(19(29-30)21(23,24)25)11-2-3-12(17(22)8-11)6-15(9-26)28-20(31)18-13-4-5-14(7-13)27-18/h2-3,8,10,13-15,18,27H,4-7H2,1H3,(H,28,31)/t13-,14+,15-,18-/m0/s1 ZEAZPEMJKLJBFP-KRXQYRFLSA-N 150444 US10238633, Example 118::US8987249, 118::US9713606, 118 Dipeptidyl peptidase 1 44.3 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150444 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150444&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430604 252824695 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500306 COc1ccccc1-c1cn(nn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C25H25FN6O2/c1-34-23-5-3-2-4-20(23)22-14-32(31-30-22)19-9-7-15(21(26)12-19)10-18(13-27)29-25(33)24-16-6-8-17(11-16)28-24/h2-5,7,9,12,14,16-18,24,28H,6,8,10-11H2,1H3,(H,29,33)/t16-,17+,18-,24-/m0/s1 FMWUNAUOLVVZHN-AIDSWVIKSA-N 150445 US10238633, Example 119::US8987249, 119::US9713606, 119 Dipeptidyl peptidase 1 51.2 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150445&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90440141 252824696 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500307 CN1C(=O)Cc2ccc(cc12)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(O)c1 InChI=1S/C25H26N4O3/c1-29-21-10-14(2-4-16(21)12-23(29)31)15-3-5-17(22(30)11-15)8-20(13-26)28-25(32)24-18-6-7-19(9-18)27-24/h2-5,10-11,18-20,24,27,30H,6-9,12H2,1H3,(H,28,32)/t18-,19+,20?,24-/m0/s1 YXZHSQPRBJFDQC-BQTZMPSMSA-N 150446 US10238633, Example 120::US8987249, 120::US9713606, 120 Dipeptidyl peptidase 1 55.6 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150446&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430568 252824697 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500308 Cc1noc(C)c1-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H23FN4O2/c1-11-19(12(2)28-26-11)14-4-3-13(18(22)9-14)7-17(10-23)25-21(27)20-15-5-6-16(8-15)24-20/h3-4,9,15-17,20,24H,5-8H2,1-2H3,(H,25,27)/t15-,16+,17-,20-/m0/s1 PHUAZJBZKNQTIM-CLWJZODNSA-N 150447 US10238633, Example 121::US8987249, 121::US9713606, 121 Dipeptidyl peptidase 1 156 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150447&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430644 252824698 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500309 CN1C(=O)Cc2ccc(cc12)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(OCc2ccccc2)c1 InChI=1S/C32H32N4O3/c1-36-28-15-21(7-9-23(28)17-30(36)37)22-8-10-24(29(16-22)39-19-20-5-3-2-4-6-20)13-27(18-33)35-32(38)31-25-11-12-26(14-25)34-31/h2-10,15-16,25-27,31,34H,11-14,17,19H2,1H3,(H,35,38)/t25-,26+,27?,31-/m0/s1 VGNUUKUQMUQSQR-NKFYVHBOSA-N 150448 US10238633, Example 122::US8987249, 122::US9713606, 122 Dipeptidyl peptidase 1 182 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150448&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430655 252824699 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500310 O=C(NC(Cc1ccc2c(c1)[nH]c(=O)c1ccccc21)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 150449 US10238633, Example 123::US8987249, 123::US9713606, 123 Dipeptidyl peptidase 1 187 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150449 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150449&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937192 252824700 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500311 CC(C)OCc1cn(nn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H27FN6O2/c1-13(2)31-12-18-11-29(28-27-18)19-6-4-14(20(23)9-19)7-17(10-24)26-22(30)21-15-3-5-16(8-15)25-21/h4,6,9,11,13,15-17,21,25H,3,5,7-8,12H2,1-2H3,(H,26,30)/t15-,16+,17-,21-/m0/s1 QPKNBTUQMSLXJI-DLRJPAPCSA-N 150450 US10238633, Example 124::US8987249, 124::US9713606, 124 Dipeptidyl peptidase 1 187 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150450 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150450&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430741 252824701 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500312 CN1CCN(C(=O)C1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H26FN5O2/c1-26-6-7-27(19(28)12-26)17-5-3-13(18(22)10-17)8-16(11-23)25-21(29)20-14-2-4-15(9-14)24-20/h3,5,10,14-16,20,24H,2,4,6-9,12H2,1H3,(H,25,29)/t14-,15+,16-,20-/m0/s1 HXBNPWRCCJXQEN-QOIOWGMHSA-N 150451 US10238633, Example 125::US8987249, 125::US9713606, 125 Dipeptidyl peptidase 1 206 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150451 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150451&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430608 252824702 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50263307 CC[C@H](C(=O)N[C@H]1CCN(CC(=O)NC\C=C\S(C)(=O)=O)C1=O)c1cc(Cl)cc(Cl)c1 InChI=1S/C20H25Cl2N3O5S/c1-3-16(13-9-14(21)11-15(22)10-13)19(27)24-17-5-7-25(20(17)28)12-18(26)23-6-4-8-31(2,29)30/h4,8-11,16-17H,3,5-7,12H2,1-2H3,(H,23,26)(H,24,27)/b8-4+/t16-,17-/m0/s1 SRZWDJLAFGSPHH-ALOLOFKDSA-N 50042851 CHEMBL3354499 Dipeptidyl peptidase 1 >100000 ChEMBL 10.1016/j.bmcl.2014.12.057 10.7270/Q20G3MSB 25571794 Grosche, P; Sirockin, F; Mac Sweeney, A; Ramage, P; Erbel, P; Melkko, S; Bernardi, A; Hughes, N; Ellis, D; Combrink, KD; Jarousse, N; Altmann, E Novartis Institute for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042851&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118720239 313067910 CHEMBL3354499 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50263308 CCN[C@H](C(=O)N[C@H](C(=O)NCC(=O)NC\C=C\S(C)(=O)=O)C(C)(C)C)c1cc(Cl)cc(Cl)c1 InChI=1S/C22H32Cl2N4O5S/c1-6-25-18(14-10-15(23)12-16(24)11-14)20(30)28-19(22(2,3)4)21(31)27-13-17(29)26-8-7-9-34(5,32)33/h7,9-12,18-19,25H,6,8,13H2,1-5H3,(H,26,29)(H,27,31)(H,28,30)/b9-7+/t18-,19+/m0/s1 IZDGDSURTWKPSK-HKBUGEINSA-N 50042852 CHEMBL3354498 Dipeptidyl peptidase 1 >100000 ChEMBL 10.1016/j.bmcl.2014.12.057 10.7270/Q20G3MSB 25571794 Grosche, P; Sirockin, F; Mac Sweeney, A; Ramage, P; Erbel, P; Melkko, S; Bernardi, A; Hughes, N; Ellis, D; Combrink, KD; Jarousse, N; Altmann, E Novartis Institute for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042852 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042852&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118720238 313067911 CHEMBL3354498 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50263309 CC(C)(C)[C@H](NC(=O)Cc1cc(Cl)cc(Cl)c1)C(=O)NCC(=O)NC\C=C\S(C)(=O)=O InChI=1S/C20H27Cl2N3O5S/c1-20(2,3)18(25-16(26)10-13-8-14(21)11-15(22)9-13)19(28)24-12-17(27)23-6-5-7-31(4,29)30/h5,7-9,11,18H,6,10,12H2,1-4H3,(H,23,27)(H,24,28)(H,25,26)/b7-5+/t18-/m1/s1 CJPQKDCNIAERJN-SUQGKYDKSA-N 50042854 CHEMBL3354497 Dipeptidyl peptidase 1 >100000 ChEMBL 10.1016/j.bmcl.2014.12.057 10.7270/Q20G3MSB 25571794 Grosche, P; Sirockin, F; Mac Sweeney, A; Ramage, P; Erbel, P; Melkko, S; Bernardi, A; Hughes, N; Ellis, D; Combrink, KD; Jarousse, N; Altmann, E Novartis Institute for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042854&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118720237 313067912 CHEMBL3354497 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50263310 COc1ccc(cc1C(=O)C(C)(C)c1cc(Cl)cc(Cl)c1)C(=O)NCC(=O)NC\C=C\S(C)(=O)=O InChI=1S/C24H26Cl2N2O6S/c1-24(2,16-11-17(25)13-18(26)12-16)22(30)19-10-15(6-7-20(19)34-3)23(31)28-14-21(29)27-8-5-9-35(4,32)33/h5-7,9-13H,8,14H2,1-4H3,(H,27,29)(H,28,31)/b9-5+ SSLOWHLLWHTKDK-WEVVVXLNSA-N 50042855 CHEMBL3354496 Dipeptidyl peptidase 1 >100000 ChEMBL 10.1016/j.bmcl.2014.12.057 10.7270/Q20G3MSB 25571794 Grosche, P; Sirockin, F; Mac Sweeney, A; Ramage, P; Erbel, P; Melkko, S; Bernardi, A; Hughes, N; Ellis, D; Combrink, KD; Jarousse, N; Altmann, E Novartis Institute for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042855&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118720236 313067913 CHEMBL3354496 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50263311 CN(C)CCOc1ccc(cc1C(=O)C(C)(C)c1cc(Cl)cc(Cl)c1)C(=O)NCc1ccnc(n1)C#N InChI=1S/C27H27Cl2N5O3/c1-27(2,18-12-19(28)14-20(29)13-18)25(35)22-11-17(5-6-23(22)37-10-9-34(3)4)26(36)32-16-21-7-8-31-24(15-30)33-21/h5-8,11-14H,9-10,16H2,1-4H3,(H,32,36) HNFUPLJEUVTDOT-UHFFFAOYSA-N 50042856 CHEMBL3354495 Dipeptidyl peptidase 1 18000 ChEMBL 10.1016/j.bmcl.2014.12.057 10.7270/Q20G3MSB 25571794 Grosche, P; Sirockin, F; Mac Sweeney, A; Ramage, P; Erbel, P; Melkko, S; Bernardi, A; Hughes, N; Ellis, D; Combrink, KD; Jarousse, N; Altmann, E Novartis Institute for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042856 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042856&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118720235 313067914 CHEMBL3354495 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50263312 COc1ccc(cc1C(=O)C(C)(C)c1cc(Cl)cc(Cl)c1)C(=O)NCc1ccnc(n1)C#N InChI=1S/C24H20Cl2N4O3/c1-24(2,15-9-16(25)11-17(26)10-15)22(31)19-8-14(4-5-20(19)33-3)23(32)29-13-18-6-7-28-21(12-27)30-18/h4-11H,13H2,1-3H3,(H,29,32) WCQQOAFZCDVMEP-UHFFFAOYSA-N 50042857 CHEMBL3354494 Dipeptidyl peptidase 1 66000 ChEMBL 10.1016/j.bmcl.2014.12.057 10.7270/Q20G3MSB 25571794 Grosche, P; Sirockin, F; Mac Sweeney, A; Ramage, P; Erbel, P; Melkko, S; Bernardi, A; Hughes, N; Ellis, D; Combrink, KD; Jarousse, N; Altmann, E Novartis Institute for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042857&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 3VF 4WX4 118720234 313067915 CHEMBL3354494 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50263313 CN(C)CCOc1ccc(cc1C(=O)C(C)(C)c1cc(Cl)cc(Cl)c1)C(=O)NCC(=O)NCC#N InChI=1S/C25H28Cl2N4O4/c1-25(2,17-12-18(26)14-19(27)13-17)23(33)20-11-16(5-6-21(20)35-10-9-31(3)4)24(34)30-15-22(32)29-8-7-28/h5-6,11-14H,8-10,15H2,1-4H3,(H,29,32)(H,30,34) LUHJTZQBKQQNIT-UHFFFAOYSA-N 50042858 CHEMBL3354493 Dipeptidyl peptidase 1 >100000 ChEMBL 10.1016/j.bmcl.2014.12.057 10.7270/Q20G3MSB 25571794 Grosche, P; Sirockin, F; Mac Sweeney, A; Ramage, P; Erbel, P; Melkko, S; Bernardi, A; Hughes, N; Ellis, D; Combrink, KD; Jarousse, N; Altmann, E Novartis Institute for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042858&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118720233 313067916 CHEMBL3354493 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50263314 COc1ccc(cc1C(=O)C(C)(C)c1cc(Cl)cc(Cl)c1)C(=O)NCC(=O)NCC#N InChI=1S/C22H21Cl2N3O4/c1-22(2,14-9-15(23)11-16(24)10-14)20(29)17-8-13(4-5-18(17)31-3)21(30)27-12-19(28)26-7-6-25/h4-5,8-11H,7,12H2,1-3H3,(H,26,28)(H,27,30) MXZCYVQMFRKLKM-UHFFFAOYSA-N 50042850 CHEMBL3354492 Dipeptidyl peptidase 1 >100000 ChEMBL 10.1016/j.bmcl.2014.12.057 10.7270/Q20G3MSB 25571794 Grosche, P; Sirockin, F; Mac Sweeney, A; Ramage, P; Erbel, P; Melkko, S; Bernardi, A; Hughes, N; Ellis, D; Combrink, KD; Jarousse, N; Altmann, E Novartis Institute for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042850 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042850&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118720232 313067909 CHEMBL3354492 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500313 Cc1cnn(C)c1-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H24FN5O/c1-12-11-24-27(2)20(12)15-4-3-13(18(22)9-15)7-17(10-23)26-21(28)19-14-5-6-16(8-14)25-19/h3-4,9,11,14,16-17,19,25H,5-8H2,1-2H3,(H,26,28)/t14-,16+,17-,19-/m0/s1 FIDRPXYSWGIXNB-RUENVJTFSA-N 150452 US10238633, Example 126::US8987249, 126::US9713606, 126 Dipeptidyl peptidase 1 275 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150452 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150452&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430625 252824703 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500314 O=C(NC(Cc1ccc2cn[nH]c2c1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 150453 US10238633, Example 127::US8987249, 127::US9713606, 127 Dipeptidyl peptidase 1 860 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150453 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150453&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430742 252824704 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500315 O=C(NC(Cc1cccc2[nH]c(=O)c3ccccc3c12)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 150454 US10238633, Example 128::US8987249, 128::US9713606, 128 Dipeptidyl peptidase 1 2393 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150454 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150454&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937193 252824705 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500316 Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C25H23FN4O3/c1-30-21-8-13(4-5-22(21)33-25(30)32)12-2-3-14(19(26)7-12)6-15(11-27)28-24(31)23-18-10-20(29-23)17-9-16(17)18/h2-5,7-8,15-18,20,23,29H,6,9-10H2,1H3,(H,28,31)/t15-,16+,17-,18+,20-,23-/m0/s1 FUXYTNBGQFZKOD-MPYHZQTKSA-N 150455 US10238633, Example 129::US8987249, 129::US9713606, 129 Dipeptidyl peptidase 1 82.7 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150455 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150455&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90440142 252824706 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500317 NC(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C24H23FN4O2/c25-20-8-14(12-1-3-13(4-2-12)23(27)30)5-6-15(20)7-16(11-26)28-24(31)22-19-10-21(29-22)18-9-17(18)19/h1-6,8,16-19,21-22,29H,7,9-10H2,(H2,27,30)(H,28,31)/t16-,17+,18-,19+,21-,22-/m0/s1 XBPOSPXPHLIHFW-RVEDGADZSA-N 150456 US10238633, Example 130::US8987249, 130::US9713606, 130 Dipeptidyl peptidase 1 43.5 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150456 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150456&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430390 252824707 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500318 CC(=O)Nc1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C25H25FN4O2/c1-13(31)28-17-6-4-14(5-7-17)15-2-3-16(22(26)9-15)8-18(12-27)29-25(32)24-21-11-23(30-24)20-10-19(20)21/h2-7,9,18-21,23-24,30H,8,10-11H2,1H3,(H,28,31)(H,29,32)/t18-,19+,20-,21+,23-,24-/m0/s1 SJDNSJYCAUFUFP-KXNGWZAWSA-N 150457 US10238633, Example 131::US8987249, 131::US9713606, 131 Dipeptidyl peptidase 1 139 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150457 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150457&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430333 252824708 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500319 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@H]2C[C@@H]1[C@@H]1C[C@H]21)C#N)-c1ccc(C#N)c(F)c1 InChI=1S/C24H20F2N4O/c25-20-6-12(13-2-4-15(10-27)21(26)7-13)1-3-14(20)5-16(11-28)29-24(31)23-19-9-22(30-23)18-8-17(18)19/h1-4,6-7,16-19,22-23,30H,5,8-9H2,(H,29,31)/t16-,17+,18-,19+,22-,23-/m0/s1 VUMXUAUWTBHETB-SFJJLGKISA-N 150458 US10238633, Example 132::US8987249, 132::US9713606, 132 Dipeptidyl peptidase 1 18.9 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150458&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430755 252824709 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500320 COC(=O)c1cc(cs1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C23H22FN3O3S/c1-30-23(29)20-6-13(10-31-20)11-2-3-12(18(24)5-11)4-14(9-25)26-22(28)21-17-8-19(27-21)16-7-15(16)17/h2-3,5-6,10,14-17,19,21,27H,4,7-8H2,1H3,(H,26,28)/t14-,15+,16-,17+,19-,21-/m0/s1 YCGQHGQZFQYOAZ-TXQSJXHQSA-N 150459 US10238633, Example 133::US8987249, 133::US9713606, 133 Dipeptidyl peptidase 1 16.1 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150459&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90440143 252824710 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500321 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@H]2C[C@@H]1[C@@H]1C[C@H]21)C#N)-c1ccc2NC(=O)Cc2c1 InChI=1S/C25H23FN4O2/c26-20-7-13(12-3-4-21-15(5-12)8-23(31)29-21)1-2-14(20)6-16(11-27)28-25(32)24-19-10-22(30-24)18-9-17(18)19/h1-5,7,16-19,22,24,30H,6,8-10H2,(H,28,32)(H,29,31)/t16-,17+,18-,19+,22-,24-/m0/s1 BPBLBLWVDZTDMM-LADXIUKTSA-N 150460 US10238633, Example 134::US8987249, 134::US9713606, 134 Dipeptidyl peptidase 1 17.8 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150460 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150460&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430759 252824711 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500322 Cn1cc2ccc(cc2n1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C25H24FN5O/c1-31-12-16-5-3-14(8-22(16)30-31)13-2-4-15(21(26)7-13)6-17(11-27)28-25(32)24-20-10-23(29-24)19-9-18(19)20/h2-5,7-8,12,17-20,23-24,29H,6,9-10H2,1H3,(H,28,32)/t17-,18+,19-,20+,23-,24-/m0/s1 OIWYRYIPQPDPIM-XJMWNJKVSA-N 150461 US10238633, Example 135::US8987249, 135::US9713606, 135 Dipeptidyl peptidase 1 286 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150461 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150461&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430782 252824712 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500323 NS(=O)(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C23H23FN4O3S/c24-20-8-13(12-3-5-16(6-4-12)32(26,30)31)1-2-14(20)7-15(11-25)27-23(29)22-19-10-21(28-22)18-9-17(18)19/h1-6,8,15,17-19,21-22,28H,7,9-10H2,(H,27,29)(H2,26,30,31)/t15-,17+,18-,19+,21-,22-/m0/s1 KQPFXAKCEUMOIW-LNHKNWPKSA-N 150462 US10238633, Example 136::US8987249, 136::US9713606, 136 Dipeptidyl peptidase 1 10.2 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150462 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150462&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937194 252824713 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500327 CS(=O)(=O)Nc1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C24H25FN4O3S/c1-33(31,32)29-16-6-4-13(5-7-16)14-2-3-15(21(25)9-14)8-17(12-26)27-24(30)23-20-11-22(28-23)19-10-18(19)20/h2-7,9,17-20,22-23,28-29H,8,10-11H2,1H3,(H,27,30)/t17-,18+,19-,20+,22-,23-/m0/s1 BCAZJKORVAFQTP-IYDLXWBISA-N 150466 US10238633, Example 140::US8987249, 140::US9713606, 140 Dipeptidyl peptidase 1 21.5 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150466 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150466&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430222 252824717 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500328 CS(=O)(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C24H24FN3O3S/c1-32(30,31)17-6-4-13(5-7-17)14-2-3-15(21(25)9-14)8-16(12-26)27-24(29)23-20-11-22(28-23)19-10-18(19)20/h2-7,9,16,18-20,22-23,28H,8,10-11H2,1H3,(H,27,29)/t16-,18+,19-,20+,22-,23-/m0/s1 UYWCFMFTAPJUIH-VUPWWPOFSA-N 150467 US10238633, Example 141::US8987249, 141::US9713606, 141 Dipeptidyl peptidase 1 36.6 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150467 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150467&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90440144 252824718 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500324 Cn1ncc2cc(ccc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C25H24FN5O/c1-31-23-5-4-13(6-16(23)12-28-31)14-2-3-15(21(26)8-14)7-17(11-27)29-25(32)24-20-10-22(30-24)19-9-18(19)20/h2-6,8,12,17-20,22,24,30H,7,9-10H2,1H3,(H,29,32)/t17-,18+,19-,20+,22-,24-/m0/s1 CHXQHZPGIICLSV-BMSLZKTOSA-N 150463 US10238633, Example 137::US8987249, 137::US9713606, 137 Dipeptidyl peptidase 1 59.7 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150463 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150463&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430204 252824714 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500325 CCn1cc(cn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C22H24FN5O/c1-2-28-11-14(10-25-28)12-3-4-13(19(23)6-12)5-15(9-24)26-22(29)21-18-8-20(27-21)17-7-16(17)18/h3-4,6,10-11,15-18,20-21,27H,2,5,7-8H2,1H3,(H,26,29)/t15-,16+,17-,18+,20-,21-/m0/s1 AOKRMUHLKCKEIK-FJEWGBTGSA-N 150464 US10238633, Example 138::US8987249, 138::US9713606, 138 Dipeptidyl peptidase 1 14.5 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150464 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150464&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430254 252824715 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500326 CS(=O)(=O)Nc1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C24H25FN4O3S/c1-33(31,32)29-16-4-2-3-13(7-16)14-5-6-15(21(25)9-14)8-17(12-26)27-24(30)23-20-11-22(28-23)19-10-18(19)20/h2-7,9,17-20,22-23,28-29H,8,10-11H2,1H3,(H,27,30)/t17-,18+,19-,20+,22-,23-/m0/s1 XHJXZNFMYRTAPM-IYDLXWBISA-N 150465 US10238633, Example 139::US8987249, 139::US9713606, 139 Dipeptidyl peptidase 1 11.7 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150465 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150465&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937195 252824716 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500330 NS(=O)(=O)c1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C23H23FN4O3S/c24-20-8-13(12-2-1-3-16(7-12)32(26,30)31)4-5-14(20)6-15(11-25)27-23(29)22-19-10-21(28-22)18-9-17(18)19/h1-5,7-8,15,17-19,21-22,28H,6,9-10H2,(H,27,29)(H2,26,30,31)/t15-,17+,18-,19+,21-,22-/m0/s1 FWBVDUGYEFVZSF-LNHKNWPKSA-N 150469 US10238633, Example 143::US8987249, 143::US9713606, 143 Dipeptidyl peptidase 1 6.70 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150469 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150469&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430485 252824720 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500331 CS(=O)(=O)c1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C24H24FN3O3S/c1-32(30,31)17-4-2-3-13(8-17)14-5-6-15(21(25)9-14)7-16(12-26)27-24(29)23-20-11-22(28-23)19-10-18(19)20/h2-6,8-9,16,18-20,22-23,28H,7,10-11H2,1H3,(H,27,29)/t16-,18+,19-,20+,22-,23-/m0/s1 YEGLUNIHKAHCKL-VUPWWPOFSA-N 150470 US10238633, Example 144::US8987249, 144::US9713606, 144 Dipeptidyl peptidase 1 26.3 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150470 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150470&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430627 252824721 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500332 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@H]2C[C@@H]1[C@@H]1C[C@H]21)C#N)-c1ccc(Cl)nc1 InChI=1S/C22H20ClFN4O/c23-20-4-3-13(10-26-20)11-1-2-12(18(24)6-11)5-14(9-25)27-22(29)21-17-8-19(28-21)16-7-15(16)17/h1-4,6,10,14-17,19,21,28H,5,7-8H2,(H,27,29)/t14-,15+,16-,17+,19-,21-/m0/s1 ZGRYOFAIQXJOSA-TXQSJXHQSA-N 150471 US10238633, Example 145::US8987249, 145::US9713606, 145 Dipeptidyl peptidase 1 53.8 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150471 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150471&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430628 252824722 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500333 NC(=O)c1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C24H23FN4O2/c25-20-8-13(12-2-1-3-15(6-12)23(27)30)4-5-14(20)7-16(11-26)28-24(31)22-19-10-21(29-22)18-9-17(18)19/h1-6,8,16-19,21-22,29H,7,9-10H2,(H2,27,30)(H,28,31)/t16-,17+,18-,19+,21-,22-/m0/s1 MVZGYAKRZLZBEL-RVEDGADZSA-N 150472 US10238633, Example 146::US8987249, 146::US9713606, 146 Dipeptidyl peptidase 1 30.5 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150472 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150472&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430629 252824723 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500334 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@H]2C[C@@H]1[C@@H]1C[C@H]21)C#N)-c1ccc2C(=O)NCc2c1 InChI=1S/C25H23FN4O2/c26-21-7-13(12-3-4-17-15(5-12)11-28-24(17)31)1-2-14(21)6-16(10-27)29-25(32)23-20-9-22(30-23)19-8-18(19)20/h1-5,7,16,18-20,22-23,30H,6,8-9,11H2,(H,28,31)(H,29,32)/t16-,18+,19-,20+,22-,23-/m0/s1 XGTPTZPXCXMRBF-VUPWWPOFSA-N 150473 US10238633, Example 147::US8987249, 147::US9713606, 147 Dipeptidyl peptidase 1 6.20 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150473 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150473&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430679 252824724 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500335 Fc1cc(ccc1CC(NC(=O)[C@H]1N[C@H]2C[C@@H]1[C@@H]1C[C@H]21)C#N)-c1ccc2C(=O)NCCc2c1 InChI=1S/C26H25FN4O2/c27-22-9-14(13-3-4-18-15(7-13)5-6-29-25(18)32)1-2-16(22)8-17(12-28)30-26(33)24-21-11-23(31-24)20-10-19(20)21/h1-4,7,9,17,19-21,23-24,31H,5-6,8,10-11H2,(H,29,32)(H,30,33)/t17?,19-,20+,21-,23+,24+/m1/s1 KLLOKUHZQAWUNF-IFZHGGHTSA-N 150474 US10238633, Example 148::US8987249, 148::US9713606, 148 Dipeptidyl peptidase 1 30.4 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150474&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430572 252824725 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500336 CN1Cc2cc(ccc2C1=O)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C26H25FN4O2/c1-31-12-16-6-13(4-5-18(16)26(31)33)14-2-3-15(22(27)8-14)7-17(11-28)29-25(32)24-21-10-23(30-24)20-9-19(20)21/h2-6,8,17,19-21,23-24,30H,7,9-10,12H2,1H3,(H,29,32)/t17-,19+,20-,21+,23-,24-/m0/s1 YVWVOYUBGOKFMC-VRTCABIXSA-N 150475 US10238633, Example 149::US8987249, 149::US9713606, 149 Dipeptidyl peptidase 1 38.7 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150475 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150475&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430573 252824726 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500337 CNS(=O)(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C24H25FN4O3S/c1-27-33(31,32)17-6-4-13(5-7-17)14-2-3-15(21(25)9-14)8-16(12-26)28-24(30)23-20-11-22(29-23)19-10-18(19)20/h2-7,9,16,18-20,22-23,27,29H,8,10-11H2,1H3,(H,28,30)/t16-,18+,19-,20+,22-,23-/m0/s1 UZSYZFPBBVJDMU-VUPWWPOFSA-N 150476 US10238633, Example 150::US8987249, 150::US9713606, 150 Dipeptidyl peptidase 1 38.6 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150476 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150476&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90440146 252824727 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500338 CCS(=O)(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C25H26FN3O3S/c1-2-33(31,32)18-7-5-14(6-8-18)15-3-4-16(22(26)10-15)9-17(13-27)28-25(30)24-21-12-23(29-24)20-11-19(20)21/h3-8,10,17,19-21,23-24,29H,2,9,11-12H2,1H3,(H,28,30)/t17-,19+,20-,21+,23-,24-/m0/s1 XTVUWKAUOSAVCH-VRTCABIXSA-N 150477 US10238633, Example 151::US8987249, 151::US9713606, 151 Dipeptidyl peptidase 1 36.9 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150477&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90440145 252824728 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500339 CS(=O)(=O)c1cc(ccc1F)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H23F2N3O3S/c1-32(30,31)21-11-14(5-7-19(21)24)13-2-3-15(20(25)10-13)8-18(12-26)28-23(29)22-16-4-6-17(9-16)27-22/h2-3,5,7,10-11,16-18,22,27H,4,6,8-9H2,1H3,(H,28,29)/t16-,17+,18-,22-/m0/s1 MQUCJSMVHXVYQA-SUWCGCSTSA-N 150478 US10238633, Example 152::US8987249, 152::US9713606, 152 Dipeptidyl peptidase 1 2.10 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150478 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150478&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430590 252824729 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500340 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cccc(c1)S(=O)(=O)C1CC1 InChI=1S/C25H26FN3O3S/c26-23-13-16(15-2-1-3-22(12-15)33(31,32)21-8-9-21)4-5-17(23)10-20(14-27)29-25(30)24-18-6-7-19(11-18)28-24/h1-5,12-13,18-21,24,28H,6-11H2,(H,29,30)/t18-,19+,20-,24-/m0/s1 OOGGADCCZJKURU-VKDGWMQASA-N 150479 US10238633, Example 153::US8987249, 153::US9713606, 153 Dipeptidyl peptidase 1 3.80 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150479&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430710 252824730 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500341 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCN(CC2CCOC2)CC1 InChI=1S/C25H34FN5O2/c26-23-13-22(31-8-6-30(7-9-31)15-17-5-10-33-16-17)4-2-18(23)11-21(14-27)29-25(32)24-19-1-3-20(12-19)28-24/h2,4,13,17,19-21,24,28H,1,3,5-12,15-16H2,(H,29,32)/t17?,19-,20+,21-,24-/m0/s1 RQKREWWZIKFSNG-FMCWYYEXSA-N 263727 US9713606, 154 Dipeptidyl peptidase 1 13.5 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263727 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263727&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118970753 377002629 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500342 CN1CCN(CC1)S(=O)(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C27H32FN5O3S/c1-32-10-12-33(13-11-32)37(35,36)24-8-5-18(6-9-24)19-2-3-20(25(28)16-19)14-23(17-29)31-27(34)26-21-4-7-22(15-21)30-26/h2-3,5-6,8-9,16,21-23,26,30H,4,7,10-15H2,1H3,(H,31,34)/t21-,22+,23-,26-/m0/s1 JTEJDGCXJPQUEE-LNEBKTTKSA-N 150481 US10238633, Example 155::US8987249, 155::US9713606, 155 Dipeptidyl peptidase 1 0.800 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150481 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150481&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430713 252824732 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500343 CC1(C)OC(=O)c2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C26H26FN3O3/c1-26(2)21-11-14(6-8-20(21)25(32)33-26)15-3-4-16(22(27)12-15)9-19(13-28)30-24(31)23-17-5-7-18(10-17)29-23/h3-4,6,8,11-12,17-19,23,29H,5,7,9-10H2,1-2H3,(H,30,31)/t17-,18+,19-,23-/m0/s1 JLXZFFFCLDPPDS-YWNPBTLJSA-N 150482 US10238633, Example 156::US8987249, 156::US9713606, 156 Dipeptidyl peptidase 1 0.600 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150482 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150482&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430711 252824733 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500344 NC(=O)c1cc(cs1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H21FN4O2S/c22-17-7-11(14-8-18(20(24)27)29-10-14)1-2-12(17)5-16(9-23)26-21(28)19-13-3-4-15(6-13)25-19/h1-2,7-8,10,13,15-16,19,25H,3-6H2,(H2,24,27)(H,26,28)/t13-,15+,16-,19-/m0/s1 PPGCNUWVAWUDDJ-YBKUAAOGSA-N 150483 US10238633, Example 157::US8987249, 157::US9713606, 157 Dipeptidyl peptidase 1 0.900 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150483&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430439 252824734 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500360 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnc(s1)C1CC1 InChI=1S/C22H23FN4OS/c23-18-9-14(19-11-25-22(29-19)12-1-2-12)4-3-13(18)7-17(10-24)27-21(28)20-15-5-6-16(8-15)26-20/h3-4,9,11-12,15-17,20,26H,1-2,5-8H2,(H,27,28)/t15-,16+,17-,20-/m0/s1 UHFZBONSCYKOGY-CLWJZODNSA-N 150499 US10238633, Example 173::US8987249, 173::US9713606, 173 Dipeptidyl peptidase 1 5.50 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150499&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430637 252824750 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500361 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnc2cccnn12 InChI=1S/C22H21FN6O/c23-18-10-14(19-12-25-20-2-1-7-26-29(19)20)4-3-13(18)8-17(11-24)28-22(30)21-15-5-6-16(9-15)27-21/h1-4,7,10,12,15-17,21,27H,5-6,8-9H2,(H,28,30)/t15-,16+,17-,21-/m0/s1 CCYSIWWCGWSLDL-DLRJPAPCSA-N 150500 US10238633, Example 174::US8987249, 174::US9713606, 174 Dipeptidyl peptidase 1 5.60 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150500&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430822 252824751 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500362 COC(=O)c1ccc(o1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H22FN3O4/c1-29-22(28)19-7-6-18(30-19)13-3-2-12(17(23)10-13)8-16(11-24)26-21(27)20-14-4-5-15(9-14)25-20/h2-3,6-7,10,14-16,20,25H,4-5,8-9H2,1H3,(H,26,27)/t14-,15+,16-,20-/m0/s1 DOSFIFURJGVDGZ-QOIOWGMHSA-N 150501 US10238633, Example 175::US8987249, 175::US9713606, 175 Dipeptidyl peptidase 1 6.30 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150501&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937197 252824752 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500363 CS(=O)(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1F InChI=1S/C23H23F2N3O3S/c1-32(30,31)18-7-3-13(4-8-18)19-9-5-14(20(24)21(19)25)10-17(12-26)28-23(29)22-15-2-6-16(11-15)27-22/h3-5,7-9,15-17,22,27H,2,6,10-11H2,1H3,(H,28,29)/t15-,16+,17-,22-/m0/s1 HFCMZDPZCZIGCP-GEYWLOKFSA-N 150502 US10238633, Example 176::US8987249, 176::US9713606, 176 Dipeptidyl peptidase 1 6.60 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150502&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430823 252824753 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500346 CS(=O)(=O)c1ccc(cc1C#N)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H23FN4O3S/c1-33(31,32)22-7-5-14(8-18(22)12-26)15-2-3-16(21(25)11-15)9-20(13-27)29-24(30)23-17-4-6-19(10-17)28-23/h2-3,5,7-8,11,17,19-20,23,28H,4,6,9-10H2,1H3,(H,29,30)/t17-,19+,20-,23-/m0/s1 ITRTUPJLHWDSML-USKVXJDGSA-N 150485 US10238633, Example 159::US8987249, 159::US9713606, 159 Dipeptidyl peptidase 1 1.60 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150485 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150485&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430392 252824736 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500347 Cc1nn(C)cc1-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H24FN5O/c1-12-18(11-27(2)26-12)13-3-4-14(19(22)9-13)7-17(10-23)25-21(28)20-15-5-6-16(8-15)24-20/h3-4,9,11,15-17,20,24H,5-8H2,1-2H3,(H,25,28)/t15-,16+,17-,20-/m0/s1 PJLDKVMJPLPBAC-CLWJZODNSA-N 150486 US10238633, Example 160::US8987249, 160::US9713606, 160 Dipeptidyl peptidase 1 1.70 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150486 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150486&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430385 252824737 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500348 CNC(=O)c1cc(cs1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H23FN4O2S/c1-25-21(28)19-9-15(11-30-19)12-2-3-13(18(23)8-12)6-17(10-24)27-22(29)20-14-4-5-16(7-14)26-20/h2-3,8-9,11,14,16-17,20,26H,4-7H2,1H3,(H,25,28)(H,27,29)/t14-,16+,17-,20-/m0/s1 XLNGTIPWUNYKLV-FORWCCJISA-N 150487 US10238633, Example 161::US8987249, 161::US9713606, 161 Dipeptidyl peptidase 1 1.90 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150487 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150487&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430393 252824738 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500349 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc(o1)C#N InChI=1S/C21H19FN4O2/c22-18-9-13(19-6-5-17(11-24)28-19)2-1-12(18)7-16(10-23)26-21(27)20-14-3-4-15(8-14)25-20/h1-2,5-6,9,14-16,20,25H,3-4,7-8H2,(H,26,27)/t14-,15+,16-,20-/m0/s1 MKOXMDMJBGUVAL-QOIOWGMHSA-N 150488 US10238633, Example 162::US8987249, 162::US9713606, 162 Dipeptidyl peptidase 1 2.00 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150488 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150488&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430754 252824739 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500350 Cn1cc(cn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C20H22FN5O/c1-26-11-15(10-23-26)12-2-3-13(18(21)8-12)6-17(9-22)25-20(27)19-14-4-5-16(7-14)24-19/h2-3,8,10-11,14,16-17,19,24H,4-7H2,1H3,(H,25,27)/t14-,16+,17-,19-/m0/s1 KPMQKTGWDITMBY-RUENVJTFSA-N 150489 US10238633, Example 163::US8987249, 163::US9713606, 163 Dipeptidyl peptidase 1 2.10 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150489 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150489&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430794 252824740 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500351 CCCNC(=O)c1cc(cs1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H27FN4O2S/c1-2-7-27-23(30)21-11-17(13-32-21)14-3-4-15(20(25)10-14)8-19(12-26)29-24(31)22-16-5-6-18(9-16)28-22/h3-4,10-11,13,16,18-19,22,28H,2,5-9H2,1H3,(H,27,30)(H,29,31)/t16-,18+,19-,22-/m0/s1 YDADTGZYWBWBFN-ZBPHCFQXSA-N 150490 US10238633, Example 164::US8987249, 164::US9713606, 164 Dipeptidyl peptidase 1 2.30 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150490 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150490&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430864 252824741 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500352 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1csc(c1)C(=O)N1CCCC1 InChI=1S/C25H27FN4O2S/c26-21-11-15(18-12-22(33-14-18)25(32)30-7-1-2-8-30)3-4-16(21)9-20(13-27)29-24(31)23-17-5-6-19(10-17)28-23/h3-4,11-12,14,17,19-20,23,28H,1-2,5-10H2,(H,29,31)/t17-,19+,20-,23-/m0/s1 LDCGUTCTCPBDJA-USKVXJDGSA-N 150491 US10238633, Example 165::US8987249, 165::US9713606, 165 Dipeptidyl peptidase 1 2.70 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150491 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150491&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430758 252824742 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500353 CC1(C)OC(=O)c2cc(ccc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C26H26FN3O3/c1-26(2)21-8-6-14(11-20(21)25(32)33-26)15-3-4-16(22(27)12-15)9-19(13-28)30-24(31)23-17-5-7-18(10-17)29-23/h3-4,6,8,11-12,17-19,23,29H,5,7,9-10H2,1-2H3,(H,30,31)/t17-,18+,19-,23-/m0/s1 OAJPZRYTQVCUSS-YWNPBTLJSA-N 150492 US10238633, Example 166::US8987249, 166::US9713606, 166 Dipeptidyl peptidase 1 3.30 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150492 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150492&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430865 252824743 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500354 NC(=O)c1ccc(o1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H21FN4O3/c22-16-9-12(17-5-6-18(29-17)20(24)27)2-1-11(16)7-15(10-23)26-21(28)19-13-3-4-14(8-13)25-19/h1-2,5-6,9,13-15,19,25H,3-4,7-8H2,(H2,24,27)(H,26,28)/t13-,14+,15-,19-/m0/s1 QWPJDKJCATZPMT-YGTYGHESSA-N 150493 US10238633, Example 167::US8987249, 167::US9713606, 167 Dipeptidyl peptidase 1 3.40 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150493 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150493&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430248 252824744 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500355 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnn2cccnc12 InChI=1S/C22H21FN6O/c23-19-10-13(18-12-26-29-7-1-6-25-21(18)29)2-3-14(19)8-17(11-24)28-22(30)20-15-4-5-16(9-15)27-20/h1-3,6-7,10,12,15-17,20,27H,4-5,8-9H2,(H,28,30)/t15-,16+,17-,20-/m0/s1 UAJICJMQOYRRAS-CLWJZODNSA-N 150494 US10238633, Example 168::US8987249, 168::US9713606, 168 Dipeptidyl peptidase 1 3.70 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150494 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150494&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430249 252824745 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500356 CN1Cc2cc(ccc2S1(=O)=O)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H25FN4O3S/c1-29-13-18-8-14(5-7-22(18)33(29,31)32)15-2-3-16(21(25)11-15)9-20(12-26)28-24(30)23-17-4-6-19(10-17)27-23/h2-3,5,7-8,11,17,19-20,23,27H,4,6,9-10,13H2,1H3,(H,28,30)/t17-,19+,20-,23-/m0/s1 LHDHATUHLZCALX-USKVXJDGSA-N 150495 US10238633, Example 169::US8987249, 169::US9713606, 169 Dipeptidyl peptidase 1 4.10 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150495&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430258 252824746 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500357 CN(C)C(=O)c1cc(cs1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H25FN4O2S/c1-28(2)23(30)20-10-16(12-31-20)13-3-4-14(19(24)9-13)7-18(11-25)27-22(29)21-15-5-6-17(8-15)26-21/h3-4,9-10,12,15,17-18,21,26H,5-8H2,1-2H3,(H,27,29)/t15-,17+,18-,21-/m0/s1 BMZNBIDFQPNVPA-DKXUYOFUSA-N 150496 US10238633, Example 170::US8987249, 170::US9713606, 170 Dipeptidyl peptidase 1 4.20 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150496&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430265 252824747 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500358 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnn(c1)-c1ccccc1 InChI=1S/C25H24FN5O/c26-23-12-16(19-14-28-31(15-19)22-4-2-1-3-5-22)6-7-17(23)10-21(13-27)30-25(32)24-18-8-9-20(11-18)29-24/h1-7,12,14-15,18,20-21,24,29H,8-11H2,(H,30,32)/t18-,20+,21-,24-/m0/s1 DMZSQOLHWTVSKK-UQWVPHONSA-N 150497 US10238633, Example 171::US8987249, 171::US9713606, 171 Dipeptidyl peptidase 1 5.00 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150497&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430257 252824748 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500359 CCOc1nc(cs1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H23FN4O2S/c1-2-28-21-26-18(11-29-21)13-4-3-12(17(22)9-13)7-16(10-23)25-20(27)19-14-5-6-15(8-14)24-19/h3-4,9,11,14-16,19,24H,2,5-8H2,1H3,(H,25,27)/t14-,15+,16-,19-/m0/s1 IWTOEPXDCLKGJZ-RCJHGTSTSA-N 150498 US10238633, Example 172::US8987249, 172::US9713606, 172 Dipeptidyl peptidase 1 5.20 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150498 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150498&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937196 252824749 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500379 CC1CN(C)CCN1c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H30FN5O/c1-14-13-27(2)7-8-28(14)19-6-4-15(20(23)11-19)9-18(12-24)26-22(29)21-16-3-5-17(10-16)25-21/h4,6,11,14,16-18,21,25H,3,5,7-10,13H2,1-2H3,(H,26,29)/t14?,16-,17+,18-,21-/m0/s1 PITCSQNCAUTIHO-PGKCESFNSA-N 150518 US10238633, Example 192::US8987249, 192::US9713606, 192 Dipeptidyl peptidase 1 11.3 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150518 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150518&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430873 252824769 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500380 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCC(CC1)N1CCOCC1 InChI=1S/C25H34FN5O2/c26-23-15-22(30-7-5-21(6-8-30)31-9-11-33-12-10-31)4-2-17(23)13-20(16-27)29-25(32)24-18-1-3-19(14-18)28-24/h2,4,15,18-21,24,28H,1,3,5-14H2,(H,29,32)/t18-,19+,20-,24-/m0/s1 JABMZGKUYITGQO-VKDGWMQASA-N 150519 US10238633, Example 193::US8987249, 193::US9713606, 193 Dipeptidyl peptidase 1 12.3 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150519 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150519&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430847 252824770 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500381 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnc2cnccn12 InChI=1S/C22H21FN6O/c23-18-9-14(19-11-26-20-12-25-5-6-29(19)20)2-1-13(18)7-17(10-24)28-22(30)21-15-3-4-16(8-15)27-21/h1-2,5-6,9,11-12,15-17,21,27H,3-4,7-8H2,(H,28,30)/t15-,16+,17-,21-/m0/s1 DLTNLHDASBIQQA-DLRJPAPCSA-N 150520 US10238633, Example 194::US8987249, 194::US9713606, 194 Dipeptidyl peptidase 1 13.3 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150520 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150520&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430813 252824771 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500382 CC1(C)CCN(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H31FN4O/c1-23(2)7-9-28(10-8-23)19-6-4-15(20(24)13-19)11-18(14-25)27-22(29)21-16-3-5-17(12-16)26-21/h4,6,13,16-18,21,26H,3,5,7-12H2,1-2H3,(H,27,29)/t16-,17+,18-,21-/m0/s1 BXFGDWVBWBYTHB-NYUBLWNDSA-N 150521 US10238633, Example 195::US8987249, 195::US9713606, 195 Dipeptidyl peptidase 1 14.7 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150521&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443244 252824772 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500383 CC1CN(C(C)CN1C)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H32FN5O/c1-14-13-29(15(2)12-28(14)3)20-7-5-16(21(24)10-20)8-19(11-25)27-23(30)22-17-4-6-18(9-17)26-22/h5,7,10,14-15,17-19,22,26H,4,6,8-9,12-13H2,1-3H3,(H,27,30)/t14?,15?,17-,18+,19-,22-/m0/s1 HJMOTVPNQZUZFS-MHRVTNIKSA-N 150522 US10238633, Example 196::US8987249, 196::US9713606, 196 Dipeptidyl peptidase 1 15.1 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150522 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150522&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443160 252824773 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500388 CCN1CCC(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H31FN4O/c1-2-28-9-7-15(8-10-28)16-3-4-17(21(24)13-16)11-20(14-25)27-23(29)22-18-5-6-19(12-18)26-22/h3-4,13,15,18-20,22,26H,2,5-12H2,1H3,(H,27,29)/t18-,19+,20-,22-/m0/s1 KZEDFSYJDOOQDK-IIZPIQPGSA-N 150527 US10238633, Example 201::US8987249, 201::US9713606, 201 Dipeptidyl peptidase 1 20.1 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150527 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150527&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430343 252824778 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500389 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc(cc1)C(=O)N1CCOCC1 InChI=1S/C27H29FN4O3/c28-24-15-19(17-1-3-18(4-2-17)27(34)32-9-11-35-12-10-32)5-6-20(24)13-23(16-29)31-26(33)25-21-7-8-22(14-21)30-25/h1-6,15,21-23,25,30H,7-14H2,(H,31,33)/t21-,22+,23-,25-/m0/s1 KFKUTDHWQWJWKQ-AANQFLQQSA-N 150528 US10238633, Example 202::US8987249, 202::US9713606, 202 Dipeptidyl peptidase 1 22.9 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150528&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430344 252824779 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500390 O=C(NC(Cc1ccc2c(c1)[nH]c1ccccc21)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 150529 US10238633, Example 203::US8987249, 203::US9713606, 203 Dipeptidyl peptidase 1 23.3 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150529 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150529&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430597 252824780 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500391 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCNCC1 InChI=1S/C20H26FN5O/c21-18-11-17(26-7-5-23-6-8-26)4-2-13(18)9-16(12-22)25-20(27)19-14-1-3-15(10-14)24-19/h2,4,11,14-16,19,23-24H,1,3,5-10H2,(H,25,27)/t14-,15+,16-,19-/m0/s1 IMHSIFFWUGPDKM-RCJHGTSTSA-N 150530 BDBM150661::US10238633, Example 335::US8987249, 204::US9713606, 335 Dipeptidyl peptidase 1 24.5 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150530&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430619 252824781 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500392 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCOCC1 InChI=1S/C20H25FN4O2/c21-18-11-17(25-5-7-27-8-6-25)4-2-13(18)9-16(12-22)24-20(26)19-14-1-3-15(10-14)23-19/h2,4,11,14-16,19,23H,1,3,5-10H2,(H,24,26)/t14-,15+,16-,19-/m0/s1 ZYYSFTGHYITWSH-RCJHGTSTSA-N 150531 US10238633, Example 205::US8987249, 205::US9713606, 205 Dipeptidyl peptidase 1 25.9 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150531&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430744 252824782 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500393 Cn1c2ccccc2c2ccc(CC(NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)cc2c1=O InChI=1S/C24H24N4O2/c1-28-21-5-3-2-4-19(21)18-9-6-14(11-20(18)24(28)30)10-17(13-25)27-23(29)22-15-7-8-16(12-15)26-22/h2-6,9,11,15-17,22,26H,7-8,10,12H2,1H3,(H,27,29)/t15-,16+,17?,22-/m0/s1 WCVYQAOROBFJTQ-GDLIHOIBSA-N 150532 US10238633, Example 206::US8987249, 206::US9713606, 206 Dipeptidyl peptidase 1 26.3 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150532&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430402 252824783 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500394 Fc1ccc2c3ccc(CC(NC(=O)[C@H]4N[C@@H]5CC[C@H]4C5)C#N)cc3[nH]c(=O)c2c1 150533 US10238633, Example 207::US8987249, 207::US9713606, 207 Dipeptidyl peptidase 1 29.1 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150533&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937198 252824784 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500395 Cc1cn(C)c(n1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H24FN5O/c1-12-11-27(2)20(24-12)15-4-3-13(18(22)9-15)7-17(10-23)26-21(28)19-14-5-6-16(8-14)25-19/h3-4,9,11,14,16-17,19,25H,5-8H2,1-2H3,(H,26,28)/t14-,16+,17-,19-/m0/s1 GJGNZYPJMSRJNR-RUENVJTFSA-N 150534 US10238633, Example 208::US8987249, 208::US9713606, 208 Dipeptidyl peptidase 1 29.8 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150534&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430591 252824785 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500396 O=C(NC(Cc1ccc-2c(CCc3ccccc-23)c1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C24H25N3O/c25-14-20(27-24(28)23-18-8-9-19(13-18)26-23)12-15-5-10-22-17(11-15)7-6-16-3-1-2-4-21(16)22/h1-5,10-11,18-20,23,26H,6-9,12-13H2,(H,27,28)/t18-,19+,20?,23-/m0/s1 LBTNQDABYUUSSI-SRDOODBNSA-N 150535 US10238633, Example 209::US8987249, 209::US9713606, 209 Dipeptidyl peptidase 1 45.8 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150535&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430574 252824786 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500397 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc(cc1)C(=O)N1CCCCC1 InChI=1S/C28H31FN4O2/c29-25-16-20(18-4-6-19(7-5-18)28(35)33-12-2-1-3-13-33)8-9-21(25)14-24(17-30)32-27(34)26-22-10-11-23(15-22)31-26/h4-9,16,22-24,26,31H,1-3,10-15H2,(H,32,34)/t22-,23+,24-,26-/m0/s1 ZBKBAEOLQSSJOG-UHCVVMIDSA-N 150536 US10238633, Example 210::US8987249, 210::US9713606, 210 Dipeptidyl peptidase 1 49.4 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150536 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150536&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443249 252824787 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500398 CN(C)C(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C25H27FN4O2/c1-30(2)25(32)16-5-3-15(4-6-16)17-7-8-18(22(26)13-17)11-21(14-27)29-24(31)23-19-9-10-20(12-19)28-23/h3-8,13,19-21,23,28H,9-12H2,1-2H3,(H,29,31)/t19-,20+,21-,23-/m0/s1 KMGXMFJKQCFWPN-KGSLCBSSSA-N 150537 US10238633, Example 211::US8987249, 211::US9713606, 211 Dipeptidyl peptidase 1 61.1 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150537 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150537&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430595 252824788 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500399 O=C(NC(Cc1ccc2oc3ccccc3c2c1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C22H21N3O2/c23-12-16(25-22(26)21-14-6-7-15(11-14)24-21)9-13-5-8-20-18(10-13)17-3-1-2-4-19(17)27-20/h1-5,8,10,14-16,21,24H,6-7,9,11H2,(H,25,26)/t14-,15+,16?,21-/m0/s1 AMDWUZAQDYEPGE-DAGLJCOKSA-N 150538 US10238633, Example 212::US8987249, 212::US9713606, 212 Dipeptidyl peptidase 1 296 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150538 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150538&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430552 252824789 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500400 O=C(NC(Cc1ccc2[nH]c3ccccc3c2c1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 150539 US10238633, Example 213::US8987249, 213::US9713606, 213 Dipeptidyl peptidase 1 619 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150539 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150539&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430560 252824790 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500401 CS(=O)(=O)c1cc(ccc1C#N)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3CC[C@@H]2C3)C#N)c(F)c1 InChI=1S/C24H23FN4O3S/c1-33(31,32)22-11-15(3-5-18(22)12-26)14-2-4-16(21(25)10-14)8-20(13-27)29-24(30)23-17-6-7-19(9-17)28-23/h2-5,10-11,17,19-20,23,28H,6-9H2,1H3,(H,29,30)/t17-,19+,20+,23+/m1/s1 AUHJWFLPELHPMB-UYOCQKMUSA-N 150540 US10238633, Example 214::US8987249, 214::US9713606, 214 Dipeptidyl peptidase 1 815 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150540 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150540&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430534 252824791 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500402 Fc1ccc2c(c1)c(=O)[nH]c1cccc(CC(NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)c21 150541 US10238633, Example 215::US8987249, 215::US9713606, 215 Dipeptidyl peptidase 1 882 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150541 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150541&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937199 252824792 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500403 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc(cc1)S(=O)(=O)N1CCOCC1 InChI=1S/C26H29FN4O4S/c27-24-15-18(17-4-7-23(8-5-17)36(33,34)31-9-11-35-12-10-31)1-2-19(24)13-22(16-28)30-26(32)25-20-3-6-21(14-20)29-25/h1-2,4-5,7-8,15,20-22,25,29H,3,6,9-14H2,(H,30,32)/t20-,21+,22-,25-/m0/s1 JKOMQLYGPOVMIW-MTQWNXOMSA-N 150543 BDBM263789::US10238633, Example 217::US8987249, 217 Dipeptidyl peptidase 1 3.70 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150543 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150543&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443250 252824794 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500404 Fc1c(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)ccc(-c2cnn(CC3CCOCC3)c2)c1F InChI=1S/C25H29F2N5O2/c26-22-16(9-20(11-28)31-25(33)24-17-1-3-19(10-17)30-24)2-4-21(23(22)27)18-12-29-32(14-18)13-15-5-7-34-8-6-15/h2,4,12,14-15,17,19-20,24,30H,1,3,5-10,13H2,(H,31,33)/t17-,19+,20-,24-/m0/s1 YMORABQOPNMDEV-GHCZAOPSSA-N 150544 US10238633, Example 218::US8987249, 218::US9713606, 218 Dipeptidyl peptidase 1 18.9 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150544 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150544&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430698 252824795 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500405 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)C1CCN(Cc2ccccc2)CC1 InChI=1S/C28H33FN4O/c29-26-16-21(20-10-12-33(13-11-20)18-19-4-2-1-3-5-19)6-7-22(26)14-25(17-30)32-28(34)27-23-8-9-24(15-23)31-27/h1-7,16,20,23-25,27,31H,8-15,18H2,(H,32,34)/t23-,24+,25-,27-/m0/s1 SQFBEZWDNANXIK-SFIUMABJSA-N 150545 US10238633, Example 219::US8987249, 219::US9713606, 219 Dipeptidyl peptidase 1 37.4 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150545 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150545&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443270 252824796 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500406 O=C(N[C@@H](Cc1ccc2ccccc2c1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C20H21N3O/c21-12-18(23-20(24)19-16-7-8-17(11-16)22-19)10-13-5-6-14-3-1-2-4-15(14)9-13/h1-6,9,16-19,22H,7-8,10-11H2,(H,23,24)/t16-,17+,18-,19-/m0/s1 FNUIDHMDMWFOTD-RDGPPVDQSA-N 150546 US10238633, Example 220::US8987249, 220::US9713606, 220 Dipeptidyl peptidase 1 253 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150546 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150546&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430616 252824797 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500407 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnc2CCCn12 InChI=1S/C22H24FN5O/c23-18-10-14(19-12-25-20-2-1-7-28(19)20)4-3-13(18)8-17(11-24)27-22(29)21-15-5-6-16(9-15)26-21/h3-4,10,12,15-17,21,26H,1-2,5-9H2,(H,27,29)/t15-,16+,17-,21-/m0/s1 IJYAQVSCUDSUGF-DLRJPAPCSA-N 150547 US10238633, Example 221::US8987249, 221::US9713606, 221 Dipeptidyl peptidase 1 3.70 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150547 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150547&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430621 252824798 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500408 CS(=O)(=NC#N)c1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H24FN5O2S/c1-33(32,28-14-27)21-4-2-3-15(11-21)16-5-6-17(22(25)12-16)9-20(13-26)30-24(31)23-18-7-8-19(10-18)29-23/h2-6,11-12,18-20,23,29H,7-10H2,1H3,(H,30,31)/t18-,19+,20-,23-,33?/m0/s1 LPAPVHRQNZAJHB-PVEGDPQMSA-N 150548 US10238633, Example 222::US8987249, 222::US9713606, 222 Dipeptidyl peptidase 1 2.20 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150548 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150548&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443276 252824799 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500409 CN1CCC(=CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H27FN4O/c1-27-8-6-14(7-9-27)15-2-3-16(20(23)12-15)10-19(13-24)26-22(28)21-17-4-5-18(11-17)25-21/h2-3,6,12,17-19,21,25H,4-5,7-11H2,1H3,(H,26,28)/t17-,18+,19-,21-/m0/s1 YQARVKLTMMGHQQ-JTJHWIPRSA-N 150549 US10238633, Example 223::US8987249, 223::US9713606, 223 Dipeptidyl peptidase 1 5.90 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150549 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150549&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430440 252824800 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500410 CN1CCN(CC1)S(=O)(=O)c1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C27H32FN5O3S/c1-32-9-11-33(12-10-32)37(35,36)24-4-2-3-18(15-24)19-5-6-20(25(28)16-19)13-23(17-29)31-27(34)26-21-7-8-22(14-21)30-26/h2-6,15-16,21-23,26,30H,7-14H2,1H3,(H,31,34)/t21-,22+,23-,26-/m0/s1 BCGCLCVNTALUEW-LNEBKTTKSA-N 150550 US10238633, Example 224::US8987249, 224::US9713606, 224 Dipeptidyl peptidase 1 1.20 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150550 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150550&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430441 252824801 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500411 CN1CCN(CC1)C(=O)c1cc(cs1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C26H30FN5O2S/c1-31-6-8-32(9-7-31)26(34)23-13-19(15-35-23)16-2-3-17(22(27)12-16)10-21(14-28)30-25(33)24-18-4-5-20(11-18)29-24/h2-3,12-13,15,18,20-21,24,29H,4-11H2,1H3,(H,30,33)/t18-,20+,21-,24-/m0/s1 NGMZWVPZCPOOFW-UQWVPHONSA-N 150551 US10238633, Example 225::US8987249, 225::US9713606, 225 Dipeptidyl peptidase 1 0.800 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150551 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150551&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443275 252824802 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500412 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1csc(c1)C(=O)N1CCn2nccc2C1 InChI=1S/C27H27FN6O2S/c28-23-11-16(19-12-24(37-15-19)27(36)33-7-8-34-22(14-33)5-6-30-34)1-2-17(23)9-21(13-29)32-26(35)25-18-3-4-20(10-18)31-25/h1-2,5-6,11-12,15,18,20-21,25,31H,3-4,7-10,14H2,(H,32,35)/t18-,20+,21-,25-/m0/s1 YQNUZNHUSHDGSJ-HOSCZWGSSA-N 150552 US10238633, Example 226::US8987249, 226::US9713606, 226 Dipeptidyl peptidase 1 0.900 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150552&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443271 252824803 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500413 CC(C)N1CCN(CC1)C(=O)c1cc(cs1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C28H34FN5O2S/c1-17(2)33-7-9-34(10-8-33)28(36)25-14-21(16-37-25)18-3-4-19(24(29)13-18)11-23(15-30)32-27(35)26-20-5-6-22(12-20)31-26/h3-4,13-14,16-17,20,22-23,26,31H,5-12H2,1-2H3,(H,32,35)/t20-,22+,23-,26-/m0/s1 AAGFQGZDVAUKDA-VBZBYZBJSA-N 150553 US10238633, Example 227::US8987249, 227::US9713606, 227 Dipeptidyl peptidase 1 1.000 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150553 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150553&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443243 252824804 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500414 COCCN1CCN(CC1)C(=O)c1cc(cs1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C28H34FN5O3S/c1-37-11-10-33-6-8-34(9-7-33)28(36)25-15-21(17-38-25)18-2-3-19(24(29)14-18)12-23(16-30)32-27(35)26-20-4-5-22(13-20)31-26/h2-3,14-15,17,20,22-23,26,31H,4-13H2,1H3,(H,32,35)/t20-,22+,23-,26-/m0/s1 NMBMMMBGRONBTI-VBZBYZBJSA-N 150554 US10238633, Example 228::US8987249, 228::US9713606, 228 Dipeptidyl peptidase 1 1.60 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150554 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150554&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430442 252824805 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500415 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1csc(c1)C(=O)N1CCN(CC1)C1CC1 InChI=1S/C28H32FN5O2S/c29-24-13-17(20-14-25(37-16-20)28(36)34-9-7-33(8-10-34)23-5-6-23)1-2-18(24)11-22(15-30)32-27(35)26-19-3-4-21(12-19)31-26/h1-2,13-14,16,19,21-23,26,31H,3-12H2,(H,32,35)/t19-,21+,22-,26-/m0/s1 AJZSFQXBXRWQNH-IYCJUYGXSA-N 150555 US10238633, Example 229::US8987249, 229::US9713606, 229 Dipeptidyl peptidase 1 1.70 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150555&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443161 252824806 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500416 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1csc(c1)C(=O)N1CCOCC1 InChI=1S/C25H27FN4O3S/c26-21-11-15(18-12-22(34-14-18)25(32)30-5-7-33-8-6-30)1-2-16(21)9-20(13-27)29-24(31)23-17-3-4-19(10-17)28-23/h1-2,11-12,14,17,19-20,23,28H,3-10H2,(H,29,31)/t17-,19+,20-,23-/m0/s1 GNRZSULABSHVGF-USKVXJDGSA-N 150556 US10238633, Example 230::US8987249, 230::US9713606, 230 Dipeptidyl peptidase 1 1.80 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150556 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150556&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430671 252824807 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500417 CC(=O)N1CCN(CC1)C(=O)c1cc(cs1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C27H30FN5O3S/c1-16(34)32-6-8-33(9-7-32)27(36)24-13-20(15-37-24)17-2-3-18(23(28)12-17)10-22(14-29)31-26(35)25-19-4-5-21(11-19)30-25/h2-3,12-13,15,19,21-22,25,30H,4-11H2,1H3,(H,31,35)/t19-,21+,22-,25-/m0/s1 LJOIAAPUDIPGIQ-RBODFLQRSA-N 150557 US10238633, Example 231::US8987249, 231::US9713606, 231 Dipeptidyl peptidase 1 2.20 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150557 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150557&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443159 252824808 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500418 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1csc(c1)C(=O)N1CCN(CC(F)(F)F)CC1 InChI=1S/C27H29F4N5O2S/c28-22-11-16(1-2-17(22)9-21(13-32)34-25(37)24-18-3-4-20(10-18)33-24)19-12-23(39-14-19)26(38)36-7-5-35(6-8-36)15-27(29,30)31/h1-2,11-12,14,18,20-21,24,33H,3-10,15H2,(H,34,37)/t18-,20+,21-,24-/m0/s1 ZKDHZVVYLAZZBU-UQWVPHONSA-N 150558 US10238633, Example 232::US8987249, 232::US9713606, 232 Dipeptidyl peptidase 1 2.20 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150558&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443163 252824809 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500419 CN1CCN(CC1=O)C(=O)c1cc(cs1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C26H28FN5O3S/c1-31-6-7-32(13-23(31)33)26(35)22-11-18(14-36-22)15-2-3-16(21(27)10-15)8-20(12-28)30-25(34)24-17-4-5-19(9-17)29-24/h2-3,10-11,14,17,19-20,24,29H,4-9,13H2,1H3,(H,30,34)/t17-,19+,20-,24-/m0/s1 GZYHERLOGHRBJT-GHCZAOPSSA-N 150559 US10238633, Example 233::US8987249, 233::US9713606, 233 Dipeptidyl peptidase 1 2.20 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150559 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150559&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430672 252824810 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500420 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1csc(c1)C(=O)N1CCN2CCOCC2C1 InChI=1S/C28H32FN5O3S/c29-24-11-17(1-2-18(24)9-22(13-30)32-27(35)26-19-3-4-21(10-19)31-26)20-12-25(38-16-20)28(36)34-6-5-33-7-8-37-15-23(33)14-34/h1-2,11-12,16,19,21-23,26,31H,3-10,14-15H2,(H,32,35)/t19-,21+,22-,23?,26-/m0/s1 LZNDHEGNLIOHKM-RMDYTIRNSA-N 150560 US10238633, Example 234::US8987249, 234::US9713606, 234 Dipeptidyl peptidase 1 3.80 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150560&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443274 252824811 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500421 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1csc(c1)C(=O)NC1CCOCC1 InChI=1S/C26H29FN4O3S/c27-22-11-15(18-12-23(35-14-18)25(32)30-19-5-7-34-8-6-19)1-2-16(22)9-21(13-28)31-26(33)24-17-3-4-20(10-17)29-24/h1-2,11-12,14,17,19-21,24,29H,3-10H2,(H,30,32)(H,31,33)/t17-,20+,21-,24-/m0/s1 UPLHVYVHWWQDBR-QELHCHSZSA-N 150561 US10238633, Example 235::US8987249, 235::US9713606, 235 Dipeptidyl peptidase 1 4.70 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150561 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150561&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430386 252824812 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500422 NC(=O)c1ccc(s1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H21FN4O2S/c22-16-9-12(17-5-6-18(29-17)20(24)27)2-1-11(16)7-15(10-23)26-21(28)19-13-3-4-14(8-13)25-19/h1-2,5-6,9,13-15,19,25H,3-4,7-8H2,(H2,24,27)(H,26,28)/t13-,14+,15-,19-/m0/s1 DNXDSWIEQRGCDX-YGTYGHESSA-N 150562 US10238633, Example 236::US8987249, 236::US9713606, 236 Dipeptidyl peptidase 1 1.60 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150562 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150562&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430394 252824813 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500423 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc(s1)C(=O)N1CCn2nccc2C1 InChI=1S/C27H27FN6O2S/c28-22-13-17(23-5-6-24(37-23)27(36)33-9-10-34-21(15-33)7-8-30-34)2-1-16(22)11-20(14-29)32-26(35)25-18-3-4-19(12-18)31-25/h1-2,5-8,13,18-20,25,31H,3-4,9-12,15H2,(H,32,35)/t18-,19+,20-,25-/m0/s1 DRMBHMUJYOWYMG-ZDQHKECQSA-N 150563 US10238633, Example 237::US8987249, 237::US9713606, 237 Dipeptidyl peptidase 1 4.60 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150563 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150563&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430395 252824814 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500424 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc(o1)C(=O)N1CCN2CCOCC2C1 InChI=1S/C28H32FN5O4/c29-23-13-18(2-1-17(23)11-21(14-30)32-27(35)26-19-3-4-20(12-19)31-26)24-5-6-25(38-24)28(36)34-8-7-33-9-10-37-16-22(33)15-34/h1-2,5-6,13,19-22,26,31H,3-4,7-12,15-16H2,(H,32,35)/t19-,20+,21-,22?,26-/m0/s1 JEOANMFZMPFLAU-QJCBJTJFSA-N 150564 US10238633, Example 238::US8987249, 238::US9713606, 238 Dipeptidyl peptidase 1 14.3 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150564&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443164 252824815 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500425 NC(=O)c1coc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H21FN4O3/c22-17-7-12(18-8-14(10-29-18)20(24)27)2-1-11(17)5-16(9-23)26-21(28)19-13-3-4-15(6-13)25-19/h1-2,7-8,10,13,15-16,19,25H,3-6H2,(H2,24,27)(H,26,28)/t13-,15+,16-,19-/m0/s1 AIYPJVNZGWXDOA-YBKUAAOGSA-N 150565 US10238633, Example 239::US8987249, 239::US9713606, 239 Dipeptidyl peptidase 1 3.40 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150565 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150565&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430357 252824816 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500426 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cc(co1)C(=O)N1CCn2nccc2C1 InChI=1S/C27H27FN6O3/c28-23-11-17(24-12-19(15-37-24)27(36)33-7-8-34-22(14-33)5-6-30-34)2-1-16(23)9-21(13-29)32-26(35)25-18-3-4-20(10-18)31-25/h1-2,5-6,11-12,15,18,20-21,25,31H,3-4,7-10,14H2,(H,32,35)/t18-,20+,21-,25-/m0/s1 OZZMJNAGINALHX-HOSCZWGSSA-N 150566 US8987249, 240::US9713606, 240 Dipeptidyl peptidase 1 6.10 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150566 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150566&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443256 252824817 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500427 CN1CCN(CC1)C(=O)c1coc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C26H30FN5O3/c1-31-6-8-32(9-7-31)26(34)19-13-23(35-15-19)17-3-2-16(22(27)12-17)10-21(14-28)30-25(33)24-18-4-5-20(11-18)29-24/h2-3,12-13,15,18,20-21,24,29H,4-11H2,1H3,(H,30,33)/t18-,20+,21-,24-/m0/s1 LDLHLKGXKXFHRZ-UQWVPHONSA-N 150567 US10238633, Example 241::US8987249, 241::US9713606, 241 Dipeptidyl peptidase 1 6.80 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150567 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150567&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430227 252824818 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500428 CCNC(=O)c1coc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H25FN4O3/c1-2-26-22(29)16-10-20(31-12-16)14-4-3-13(19(24)9-14)7-18(11-25)28-23(30)21-15-5-6-17(8-15)27-21/h3-4,9-10,12,15,17-18,21,27H,2,5-8H2,1H3,(H,26,29)(H,28,30)/t15-,17+,18-,21-/m0/s1 VMZSCTQFZQDFOI-DKXUYOFUSA-N 150568 US10238633, Example 242::US8987249, 242::US9713606, 242 Dipeptidyl peptidase 1 10.9 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150568&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430247 252824819 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500429 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnn(c1)S(=O)(=O)c1ccccc1 InChI=1S/C25H24FN5O3S/c26-23-12-16(19-14-28-31(15-19)35(33,34)22-4-2-1-3-5-22)6-7-17(23)10-21(13-27)30-25(32)24-18-8-9-20(11-18)29-24/h1-7,12,14-15,18,20-21,24,29H,8-11H2,(H,30,32)/t18-,20+,21-,24-/m0/s1 QABZRGUXQDPQLL-UQWVPHONSA-N 150569 US10238633, Example 243::US8987249, 243::US9713606, 243 Dipeptidyl peptidase 1 4.80 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150569 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150569&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430207 252824820 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500430 NC(=O)c1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H23FN4O2/c24-20-11-14(13-2-1-3-17(8-13)22(26)29)4-5-15(20)9-19(12-25)28-23(30)21-16-6-7-18(10-16)27-21/h1-5,8,11,16,18-19,21,27H,6-7,9-10H2,(H2,26,29)(H,28,30)/t16-,18+,19-,21-/m0/s1 URKPBBPYGGQLCL-KRQVXIAISA-N 150570 US10238633, Example 244::US8987249, 244::US9713606, 244 Dipeptidyl peptidase 1 3.70 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150570 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150570&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430260 252824821 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500431 CN1CCN(CC1)C(=O)c1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C28H32FN5O2/c1-33-9-11-34(12-10-33)28(36)22-4-2-3-18(13-22)19-5-6-20(25(29)16-19)14-24(17-30)32-27(35)26-21-7-8-23(15-21)31-26/h2-6,13,16,21,23-24,26,31H,7-12,14-15H2,1H3,(H,32,35)/t21-,23+,24-,26-/m0/s1 VFHWVMMVSYURFG-YUZJIJRXSA-N 150571 US10238633, Example 245::US8987249, 245::US9713606, 245 Dipeptidyl peptidase 1 5.90 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150571 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150571&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443260 252824822 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500432 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc(cc1)S(=O)(=O)N1CCC(F)(F)CC1 InChI=1S/C27H29F3N4O3S/c28-24-15-18(17-4-7-23(8-5-17)38(36,37)34-11-9-27(29,30)10-12-34)1-2-19(24)13-22(16-31)33-26(35)25-20-3-6-21(14-20)32-25/h1-2,4-5,7-8,15,20-22,25,32H,3,6,9-14H2,(H,33,35)/t20-,21+,22-,25-/m0/s1 DMXKZSZRABVDLH-MTQWNXOMSA-N 150572 BDBM263819::US10238633, Example 246::US8987249, 246 Dipeptidyl peptidase 1 5.90 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150572 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150572&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430686 252824823 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500433 CN1CCCN(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H30FN5O/c1-27-7-2-8-28(10-9-27)19-6-4-15(20(23)13-19)11-18(14-24)26-22(29)21-16-3-5-17(12-16)25-21/h4,6,13,16-18,21,25H,2-3,5,7-12H2,1H3,(H,26,29)/t16-,17+,18-,21-/m0/s1 JUIRQFMPMAKJMC-NYUBLWNDSA-N 150573 US10238633, Example 247::US8987249, 247::US9713606, 247 Dipeptidyl peptidase 1 8.40 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150573 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150573&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430673 252824824 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500434 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCC2C(CCNC2=O)C1 InChI=1S/C24H30FN5O2/c25-21-11-19(30-8-6-20-16(13-30)5-7-27-23(20)31)4-2-14(21)9-18(12-26)29-24(32)22-15-1-3-17(10-15)28-22/h2,4,11,15-18,20,22,28H,1,3,5-10,13H2,(H,27,31)(H,29,32)/t15-,16?,17+,18-,20?,22-/m0/s1 PMZMGDBQXVWCAC-GAGFYFTPSA-N 150574 US10238633, Example 248::US8987249, 248::US9713606, 248 Dipeptidyl peptidase 1 18.0 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150574 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150574&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430639 252824825 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500435 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCN2CCOC[C@@H]2C1 InChI=1S/C23H30FN5O2/c24-21-11-19(29-6-5-28-7-8-31-14-20(28)13-29)4-2-15(21)9-18(12-25)27-23(30)22-16-1-3-17(10-16)26-22/h2,4,11,16-18,20,22,26H,1,3,5-10,13-14H2,(H,27,30)/t16-,17+,18-,20-,22-/m0/s1 SOLOVPGTCODBHF-FFUNNMLOSA-N 150575 US10238633, Example 249::US8987249, 249::US9713606, 249 Dipeptidyl peptidase 1 6.30 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150575&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430827 252824826 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500436 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCN2CCOC[C@H]2C1 InChI=1S/C23H30FN5O2/c24-21-11-19(29-6-5-28-7-8-31-14-20(28)13-29)4-2-15(21)9-18(12-25)27-23(30)22-16-1-3-17(10-16)26-22/h2,4,11,16-18,20,22,26H,1,3,5-10,13-14H2,(H,27,30)/t16-,17+,18-,20+,22-/m0/s1 SOLOVPGTCODBHF-JAZLEBMFSA-N 150576 US10238633, Example 250::US8987249, 250::US9713606, 250 Dipeptidyl peptidase 1 4.20 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150576 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150576&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430699 252824827 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500437 CC(C)c1cc(ccc1S(C)=O)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C26H30FN3O2S/c1-15(2)22-12-16(7-9-24(22)33(3)32)17-4-5-18(23(27)13-17)10-21(14-28)30-26(31)25-19-6-8-20(11-19)29-25/h4-5,7,9,12-13,15,19-21,25,29H,6,8,10-11H2,1-3H3,(H,30,31)/t19-,20+,21-,25-,33?/m0/s1 ZPKAAZKAWPZZBG-QGBJVGRCSA-N 263824 US10238633, Example 251::US9713606, 251 Dipeptidyl peptidase 1 11.5 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263824&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430239 377002726 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500384 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCCCC1 InChI=1S/C21H27FN4O/c22-19-12-18(26-8-2-1-3-9-26)7-5-14(19)10-17(13-23)25-21(27)20-15-4-6-16(11-15)24-20/h5,7,12,15-17,20,24H,1-4,6,8-11H2,(H,25,27)/t15-,16+,17-,20-/m0/s1 NAECJPAQRDJHFX-CLWJZODNSA-N 150523 US10238633, Example 197::US8987249, 197::US9713606, 197 Dipeptidyl peptidase 1 15.6 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150523 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150523&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430381 252824774 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500438 CS(=O)(=O)c1ccc(cc1OCC(F)F)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C25H26F3N3O4S/c1-36(33,34)22-7-5-15(11-21(22)35-13-23(27)28)14-2-3-16(20(26)10-14)8-19(12-29)31-25(32)24-17-4-6-18(9-17)30-24/h2-3,5,7,10-11,17-19,23-24,30H,4,6,8-9,13H2,1H3,(H,31,32)/t17-,18+,19-,24-/m0/s1 FJAZHJZGIXPLOY-YDLHNXBPSA-N 150578 US10238633, Example 252::US8987249, 252::US9713606, 252 Dipeptidyl peptidase 1 3.80 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150578&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430228 252824829 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500439 CNc1nc2cc(ccc2n1C)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C25H27FN6O/c1-28-25-31-21-12-15(6-8-22(21)32(25)2)14-3-4-16(20(26)11-14)9-19(13-27)30-24(33)23-17-5-7-18(10-17)29-23/h3-4,6,8,11-12,17-19,23,29H,5,7,9-10H2,1-2H3,(H,28,31)(H,30,33)/t17-,18+,19-,23-/m0/s1 VPLUWXLMJBCMPZ-YWNPBTLJSA-N 150579 US10238633, Example 253::US8987249, 253::US9713606, 253 Dipeptidyl peptidase 1 11.0 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150579&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443262 252824830 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500440 Cn1cc(ccc1=O)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H23FN4O2/c1-27-12-16(5-7-20(27)28)13-2-3-14(19(23)10-13)8-18(11-24)26-22(29)21-15-4-6-17(9-15)25-21/h2-3,5,7,10,12,15,17-18,21,25H,4,6,8-9H2,1H3,(H,26,29)/t15-,17+,18-,21-/m0/s1 DVAYQWABFZKMAR-DKXUYOFUSA-N 150580 US10238633, Example 254::US8987249, 254::US9713606, 254 Dipeptidyl peptidase 1 2.00 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150580 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150580&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430261 252824831 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500441 Cn1ccc(cc1=O)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H23FN4O2/c1-27-7-6-14(11-20(27)28)13-2-3-15(19(23)10-13)8-18(12-24)26-22(29)21-16-4-5-17(9-16)25-21/h2-3,6-7,10-11,16-18,21,25H,4-5,8-9H2,1H3,(H,26,29)/t16-,17+,18-,21-/m0/s1 ACSGJNZSMAZGRN-NYUBLWNDSA-N 150581 US10238633, Example 255::US8987249, 255::US9713606, 255 Dipeptidyl peptidase 1 10.9 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150581 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150581&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430262 252824832 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500442 CN(C)CCn1ccc(cc1=O)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C25H30FN5O2/c1-30(2)9-10-31-8-7-17(14-23(31)32)16-3-4-18(22(26)13-16)11-21(15-27)29-25(33)24-19-5-6-20(12-19)28-24/h3-4,7-8,13-14,19-21,24,28H,5-6,9-12H2,1-2H3,(H,29,33)/t19-,20+,21-,24-/m0/s1 YVLKOTSUWUCUKO-XARGGIHNSA-N 150582 US10238633, Example 256::US8987249, 256::US9713606, 256 Dipeptidyl peptidase 1 26.3 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150582 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150582&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430844 252824833 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500443 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cc[nH]c(=O)c1 150583 US10238633, Example 257::US8987249, 257::US9713606, 257 Dipeptidyl peptidase 1 39.9 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150583 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150583&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937200 252824834 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500444 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc(=O)[nH]c1 150584 US10238633, Example 258::US8987249, 258::US9713606, 258 Dipeptidyl peptidase 1 7.90 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150584 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150584&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 127053696 252824835 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500385 COC(=O)c1cc(C)c(s1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H24FN3O3S/c1-12-7-19(23(29)30-2)31-21(12)15-4-3-13(18(24)10-15)8-17(11-25)27-22(28)20-14-5-6-16(9-14)26-20/h3-4,7,10,14,16-17,20,26H,5-6,8-9H2,1-2H3,(H,27,28)/t14-,16+,17-,20-/m0/s1 TWRCTBLMEJQQQC-FORWCCJISA-N 150524 US10238633, Example 198::US8987249, 198::US9713606, 198 Dipeptidyl peptidase 1 15.8 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150524 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150524&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430382 252824775 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500386 CN1C(=O)C(C)(C)c2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C27H29FN4O2/c1-27(2)21-9-7-16(13-23(21)32(3)26(27)34)15-4-5-17(22(28)12-15)10-20(14-29)31-25(33)24-18-6-8-19(11-18)30-24/h4-5,7,9,12-13,18-20,24,30H,6,8,10-11H2,1-3H3,(H,31,33)/t18-,19+,20-,24-/m0/s1 BDKPRFCKGSLJAZ-VKDGWMQASA-N 150525 US10238633, Example 199::US8987249, 199::US9713606, 199 Dipeptidyl peptidase 1 16.0 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150525 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150525&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443273 252824776 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500387 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc(cc1)C(=O)NC1CCOCC1 InChI=1S/C28H31FN4O3/c29-25-15-19(17-1-3-18(4-2-17)27(34)32-22-9-11-36-12-10-22)5-6-20(25)13-24(16-30)33-28(35)26-21-7-8-23(14-21)31-26/h1-6,15,21-24,26,31H,7-14H2,(H,32,34)(H,33,35)/t21-,23+,24-,26-/m0/s1 YVIQKIOIKPSZTK-YUZJIJRXSA-N 150526 US10238633, Example 200::US8987249, 200::US9713606, 200 Dipeptidyl peptidase 1 16.5 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150526&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430342 252824777 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500378 COCCN1C(C)CN(CC1C)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C25H36FN5O2/c1-16-14-30(15-17(2)31(16)8-9-33-3)22-7-5-18(23(26)12-22)10-21(13-27)29-25(32)24-19-4-6-20(11-19)28-24/h5,7,12,16-17,19-21,24,28H,4,6,8-11,14-15H2,1-3H3,(H,29,32)/t16?,17?,19-,20+,21-,24-/m0/s1 KNULSPGFBWAFEV-QAGFWZOLSA-N 150517 US10238633, Example 191::US8987249, 191::US9713606, 191 Dipeptidyl peptidase 1 11.2 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150517 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150517&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430872 252824768 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500364 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc(cc1)S(=O)(=O)N1CCCCC1 InChI=1S/C27H31FN4O3S/c28-25-16-19(18-7-10-24(11-8-18)36(34,35)32-12-2-1-3-13-32)4-5-20(25)14-23(17-29)31-27(33)26-21-6-9-22(15-21)30-26/h4-5,7-8,10-11,16,21-23,26,30H,1-3,6,9,12-15H2,(H,31,33)/t21-,22+,23-,26-/m0/s1 QDYXJVMXCAOXIV-LNEBKTTKSA-N 150503 US10238633, Example 177::US8987249, 177::US9713606, 177 Dipeptidyl peptidase 1 7.40 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150503 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150503&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430824 252824754 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500365 COCCN1CCN(CC1C)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H34FN5O2/c1-16-15-30(8-7-29(16)9-10-32-2)21-6-4-17(22(25)13-21)11-20(14-26)28-24(31)23-18-3-5-19(12-18)27-23/h4,6,13,16,18-20,23,27H,3,5,7-12,15H2,1-2H3,(H,28,31)/t16?,18-,19+,20-,23-/m0/s1 OEWFJFIVDPBLOL-XPNKYNLISA-N 150504 US10238633, Example 178::US8987249, 178::US9713606, 178 Dipeptidyl peptidase 1 7.40 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150504&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443245 252824755 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500366 CCOC(=O)c1ccc(s1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H24FN3O3S/c1-2-30-23(29)20-8-7-19(31-20)14-4-3-13(18(24)11-14)9-17(12-25)27-22(28)21-15-5-6-16(10-15)26-21/h3-4,7-8,11,15-17,21,26H,2,5-6,9-10H2,1H3,(H,27,28)/t15-,16+,17-,21-/m0/s1 UYZWDKFSNQPGHZ-DLRJPAPCSA-N 150505 US10238633, Example 179::US8987249, 179::US9713606, 179 Dipeptidyl peptidase 1 7.50 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150505 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150505&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90440149 252824756 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500367 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-n1cccn1 InChI=1S/C19H20FN5O/c20-17-10-16(25-7-1-6-22-25)5-3-12(17)8-15(11-21)24-19(26)18-13-2-4-14(9-13)23-18/h1,3,5-7,10,13-15,18,23H,2,4,8-9H2,(H,24,26)/t13-,14+,15-,18-/m0/s1 YFJMUZCPWDVHKP-KRXQYRFLSA-N 150506 US10238633, Example 180::US8987249, 180::US9713606, 180 Dipeptidyl peptidase 1 7.70 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150506 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150506&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430716 252824757 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500368 Fc1c(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)ccc(c1F)-c1ccc2CC(=O)Nc2c1 InChI=1S/C24H22F2N4O2/c25-21-14(7-17(11-27)29-24(32)23-15-3-5-16(8-15)28-23)4-6-18(22(21)26)12-1-2-13-10-20(31)30-19(13)9-12/h1-2,4,6,9,15-17,23,28H,3,5,7-8,10H2,(H,29,32)(H,30,31)/t15-,16+,17-,23-/m0/s1 GZBOPPMZTWXCEG-IPPNXFFKSA-N 150507 US10238633, Example 181::US8987249, 181::US9713606, 181 Dipeptidyl peptidase 1 8.60 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150507 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150507&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443264 252824758 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500369 COCCN1CCN(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H32FN5O2/c1-31-11-10-28-6-8-29(9-7-28)20-5-3-16(21(24)14-20)12-19(15-25)27-23(30)22-17-2-4-18(13-17)26-22/h3,5,14,17-19,22,26H,2,4,6-13H2,1H3,(H,27,30)/t17-,18+,19-,22-/m0/s1 SACZOVLAILIBSM-WEMPKCCASA-N 150508 US10238633, Example 182::US8987249, 182::US9713606, 182 Dipeptidyl peptidase 1 8.80 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150508 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150508&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443246 252824759 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500370 CS(=O)(=O)c1cc(ccc1C#N)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1F InChI=1S/C24H22F2N4O3S/c1-34(32,33)20-10-13(2-3-16(20)11-27)19-7-5-14(21(25)22(19)26)8-18(12-28)30-24(31)23-15-4-6-17(9-15)29-23/h2-3,5,7,10,15,17-18,23,29H,4,6,8-9H2,1H3,(H,30,31)/t15-,17+,18-,23-/m0/s1 BHOUHJMWXTTXMV-XITLKHQFSA-N 150509 US10238633, Example 183::US8987249, 183::US9713606, 183 Dipeptidyl peptidase 1 8.80 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150509 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150509&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430803 252824760 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500371 CCNC(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C25H27FN4O2/c1-2-28-24(31)16-5-3-15(4-6-16)17-7-8-18(22(26)13-17)11-21(14-27)30-25(32)23-19-9-10-20(12-19)29-23/h3-8,13,19-21,23,29H,2,9-12H2,1H3,(H,28,31)(H,30,32)/t19-,20+,21-,23-/m0/s1 QONINOVIALYSKY-KGSLCBSSSA-N 150510 US10238633, Example 184::US8987249, 184::US9713606, 184 Dipeptidyl peptidase 1 8.80 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150510 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150510&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430780 252824761 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500372 CN1CCN(CC1)C(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C28H32FN5O2/c1-33-10-12-34(13-11-33)28(36)19-4-2-18(3-5-19)20-6-7-21(25(29)16-20)14-24(17-30)32-27(35)26-22-8-9-23(15-22)31-26/h2-7,16,22-24,26,31H,8-15H2,1H3,(H,32,35)/t22-,23+,24-,26-/m0/s1 BCTCYNYSBOFOGS-UHCVVMIDSA-N 150511 US10238633, Example 185::US8987249, 185::US9713606, 185 Dipeptidyl peptidase 1 9.00 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150511 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150511&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443251 252824762 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500373 CNC(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H25FN4O2/c1-27-23(30)15-4-2-14(3-5-15)16-6-7-17(21(25)12-16)10-20(13-26)29-24(31)22-18-8-9-19(11-18)28-22/h2-7,12,18-20,22,28H,8-11H2,1H3,(H,27,30)(H,29,31)/t18-,19+,20-,22-/m0/s1 LNYQNVOBORIQSU-IIZPIQPGSA-N 150512 US10238633, Example 186::US8987249, 186::US9713606, 186 Dipeptidyl peptidase 1 9.60 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150512 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150512&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443253 252824763 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500374 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCN(CC1)C1CC1 InChI=1S/C23H30FN5O/c24-21-13-20(29-9-7-28(8-10-29)19-5-6-19)4-2-15(21)11-18(14-25)27-23(30)22-16-1-3-17(12-16)26-22/h2,4,13,16-19,22,26H,1,3,5-12H2,(H,27,30)/t16-,17+,18-,22-/m0/s1 KRGWGKDDVUPCTC-SUWCGCSTSA-N 150513 US10238633, Example 187::US8987249, 187::US9713606, 187 Dipeptidyl peptidase 1 9.80 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150513 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150513&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430775 252824764 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500375 C[C@H]1CN(C)CCN1c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H30FN5O/c1-14-13-27(2)7-8-28(14)19-6-4-15(20(23)11-19)9-18(12-24)26-22(29)21-16-3-5-17(10-16)25-21/h4,6,11,14,16-18,21,25H,3,5,7-10,13H2,1-2H3,(H,26,29)/t14-,16-,17+,18-,21-/m0/s1 PITCSQNCAUTIHO-ODKKXURNSA-N 150514 US10238633, Example 188::US8987249, 188::US9713606, 188 Dipeptidyl peptidase 1 9.80 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150514&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430776 252824765 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500376 Fc1cc(OCCN2CCNCC2)ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N InChI=1S/C22H30FN5O2/c23-20-13-19(30-10-9-28-7-5-25-6-8-28)4-2-15(20)11-18(14-24)27-22(29)21-16-1-3-17(12-16)26-21/h2,4,13,16-18,21,25-26H,1,3,5-12H2,(H,27,29)/t16-,17+,18-,21-/m0/s1 DYZTZKMZXIOJOY-NYUBLWNDSA-N 150515 US10238633, Example 189::US8987249, 189::US9713606, 189 Dipeptidyl peptidase 1 10.4 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150515&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430777 252824766 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500377 OCCN1CCN(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H30FN5O2/c23-20-13-19(28-7-5-27(6-8-28)9-10-29)4-2-15(20)11-18(14-24)26-22(30)21-16-1-3-17(12-16)25-21/h2,4,13,16-18,21,25,29H,1,3,5-12H2,(H,26,30)/t16-,17+,18-,21-/m0/s1 JYCKJIYGTBLGHE-NYUBLWNDSA-N 150516 US10238633, Example 190::US8987249, 190::US9713606, 190 Dipeptidyl peptidase 1 10.9 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150516 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150516&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430846 252824767 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50558667 CSCC[C@H](N)C(=O)NCCc1c[nH]c2ccccc12 InChI=1S/C15H21N3OS/c1-20-9-7-13(16)15(19)17-8-6-11-10-18-14-5-3-2-4-12(11)14/h2-5,10,13,18H,6-9,16H2,1H3,(H,17,19)/t13-/m0/s1 FFPYEAYLVHOCHT-ZDUSSCGKSA-N 50310668 (S)-N-(2-(1H-indol-3-yl)ethyl)-2-amino-4-(methylthio)butanamide::CHEMBL1078551 Dipeptidyl peptidase 1 11000 ChEMBL 10.1016/j.bmcl.2009.07.114 10.7270/Q298874W 19665376 Guay, D; Beaulieu, C; Truchon, JF; Jagadeeswar Reddy, T; Zamboni, R; Bayly, CI; Methot, N; Rubin, J; Ethier, D; David Percival, M Merck Frosst Canada & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310668 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310668&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 8022437 104145029 CHEMBL1078551 ZINC06645438 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50558668 CSCC[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C#N InChI=1S/C16H20N4OS/c1-22-7-6-14(18)16(21)20-12(9-17)8-11-10-19-15-5-3-2-4-13(11)15/h2-5,10,12,14,19H,6-8,18H2,1H3,(H,20,21)/t12-,14-/m0/s1 MIWBLRIWDZAQDT-JSGCOSHPSA-N 50310669 (S)-2-amino-N-((S)-1-cyano-2-(1H-indol-3-yl)ethyl)-4-(methylthio)butanamide::CHEMBL1081329 Dipeptidyl peptidase 1 200 ChEMBL 10.1016/j.bmcl.2009.07.114 10.7270/Q298874W 19665376 Guay, D; Beaulieu, C; Truchon, JF; Jagadeeswar Reddy, T; Zamboni, R; Bayly, CI; Methot, N; Rubin, J; Ethier, D; David Percival, M Merck Frosst Canada & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310669 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310669&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 46883391 104145030 CHEMBL1081329 ZINC49033373 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50558669 CCSC[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C#N InChI=1S/C16H20N4OS/c1-2-22-10-14(18)16(21)20-12(8-17)7-11-9-19-15-6-4-3-5-13(11)15/h3-6,9,12,14,19H,2,7,10,18H2,1H3,(H,20,21)/t12-,14-/m0/s1 DULUBSMWYBEFLC-JSGCOSHPSA-N 50310670 (R)-2-amino-N-((S)-1-cyano-2-(1H-indol-3-yl)ethyl)-3-(ethylthio)propanamide::CHEMBL1082054 Dipeptidyl peptidase 1 630 ChEMBL 10.1016/j.bmcl.2009.07.114 10.7270/Q298874W 19665376 Guay, D; Beaulieu, C; Truchon, JF; Jagadeeswar Reddy, T; Zamboni, R; Bayly, CI; Methot, N; Rubin, J; Ethier, D; David Percival, M Merck Frosst Canada & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310670 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310670&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 46883392 104145031 CHEMBL1082054 ZINC49045891 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50558670 CCSCC[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C#N InChI=1S/C17H22N4OS/c1-2-23-8-7-15(19)17(22)21-13(10-18)9-12-11-20-16-6-4-3-5-14(12)16/h3-6,11,13,15,20H,2,7-9,19H2,1H3,(H,21,22)/t13-,15-/m0/s1 IGUDMUOUKIZCPL-ZFWWWQNUSA-N 50310671 (S)-2-amino-N-((S)-1-cyano-2-(1H-indol-3-yl)ethyl)-4-(ethylthio)butanamide::CHEMBL1079350 Dipeptidyl peptidase 1 1580 ChEMBL 10.1016/j.bmcl.2009.07.114 10.7270/Q298874W 19665376 Guay, D; Beaulieu, C; Truchon, JF; Jagadeeswar Reddy, T; Zamboni, R; Bayly, CI; Methot, N; Rubin, J; Ethier, D; David Percival, M Merck Frosst Canada & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310671&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 46883393 104145032 CHEMBL1079350 ZINC49032531 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50558671 CC(C)[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C#N InChI=1S/C16H20N4O/c1-10(2)15(18)16(21)20-12(8-17)7-11-9-19-14-6-4-3-5-13(11)14/h3-6,9-10,12,15,19H,7,18H2,1-2H3,(H,20,21)/t12-,15-/m0/s1 YBEJKUIYNZOLLK-WFASDCNBSA-N 50310672 (S)-2-amino-N-((S)-1-cyano-2-(1H-indol-3-yl)ethyl)-3-methylbutanamide::CHEMBL1079351 Dipeptidyl peptidase 1 330 ChEMBL 10.1016/j.bmcl.2009.07.114 10.7270/Q298874W 19665376 Guay, D; Beaulieu, C; Truchon, JF; Jagadeeswar Reddy, T; Zamboni, R; Bayly, CI; Methot, N; Rubin, J; Ethier, D; David Percival, M Merck Frosst Canada & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310672&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 46883394 104145033 CHEMBL1079351 ZINC49089628 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50558672 N[C@@H](Cc1cccs1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C#N InChI=1S/C18H18N4OS/c19-10-13(8-12-11-21-17-6-2-1-5-15(12)17)22-18(23)16(20)9-14-4-3-7-24-14/h1-7,11,13,16,21H,8-9,20H2,(H,22,23)/t13-,16-/m0/s1 UAAFPZGRKJCEOD-BBRMVZONSA-N 50310673 (S)-2-amino-N-((S)-1-cyano-2-(1H-indol-3-yl)ethyl)-3-(thiophen-2-yl)propanamide::CHEMBL1081150 Dipeptidyl peptidase 1 5.8 ChEMBL 10.1016/j.bmcl.2009.07.114 10.7270/Q298874W 19665376 Guay, D; Beaulieu, C; Truchon, JF; Jagadeeswar Reddy, T; Zamboni, R; Bayly, CI; Methot, N; Rubin, J; Ethier, D; David Percival, M Merck Frosst Canada & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310673&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 46883368 104145034 CHEMBL1081150 ZINC49032922 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50558673 N[C@@H](Cc1cccs1)C(=O)NCC#N InChI=1S/C9H11N3OS/c10-3-4-12-9(13)8(11)6-7-2-1-5-14-7/h1-2,5,8H,4,6,11H2,(H,12,13)/t8-/m0/s1 GAMDWPRVRQGRBM-QMMMGPOBSA-N 50310674 (S)-2-amino-N-(cyanomethyl)-3-(thiophen-2-yl)propanamide::CHEMBL1078120 Dipeptidyl peptidase 1 17 ChEMBL 10.1016/j.bmcl.2009.07.114 10.7270/Q298874W 19665376 Guay, D; Beaulieu, C; Truchon, JF; Jagadeeswar Reddy, T; Zamboni, R; Bayly, CI; Methot, N; Rubin, J; Ethier, D; David Percival, M Merck Frosst Canada & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310674 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310674&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 46883395 104145035 CHEMBL1078120 ZINC48998448 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50558674 CC(C)[C@H](NC(=O)[C@@H](N)Cc1cccs1)C#N InChI=1S/C12H17N3OS/c1-8(2)11(7-13)15-12(16)10(14)6-9-4-3-5-17-9/h3-5,8,10-11H,6,14H2,1-2H3,(H,15,16)/t10-,11+/m0/s1 CCYQBXNKMZQPGV-WDEREUQCSA-N 50310675 (S)-2-amino-N-((S)-1-cyano-2-methylpropyl)-3-(thiophen-2-yl)propanamide::CHEMBL1079352 Dipeptidyl peptidase 1 215 ChEMBL 10.1016/j.bmcl.2009.07.114 10.7270/Q298874W 19665376 Guay, D; Beaulieu, C; Truchon, JF; Jagadeeswar Reddy, T; Zamboni, R; Bayly, CI; Methot, N; Rubin, J; Ethier, D; David Percival, M Merck Frosst Canada & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310675&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 46883396 104145036 CHEMBL1079352 ZINC49032534 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50558675 N[C@@H](Cc1cccs1)C(=O)N[C@H](C#N)C(c1ccccc1)c1ccccc1 InChI=1S/C22H21N3OS/c23-15-20(25-22(26)19(24)14-18-12-7-13-27-18)21(16-8-3-1-4-9-16)17-10-5-2-6-11-17/h1-13,19-21H,14,24H2,(H,25,26)/t19-,20+/m0/s1 YQHOGHSPZHZAFC-VQTJNVASSA-N 50310676 (S)-2-amino-N-((S)-1-cyano-2,2-diphenylethyl)-3-(thiophen-2-yl)propanamide::CHEMBL1080601 Dipeptidyl peptidase 1 3.8 ChEMBL 10.1016/j.bmcl.2009.07.114 10.7270/Q298874W 19665376 Guay, D; Beaulieu, C; Truchon, JF; Jagadeeswar Reddy, T; Zamboni, R; Bayly, CI; Methot, N; Rubin, J; Ethier, D; David Percival, M Merck Frosst Canada & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310676&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 46883425 104145037 CHEMBL1080601 ZINC49089617 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50558676 N[C@@H](Cc1cccs1)C(=O)N[C@@H](CC1CCCCC1)C#N InChI=1S/C16H23N3OS/c17-11-13(9-12-5-2-1-3-6-12)19-16(20)15(18)10-14-7-4-8-21-14/h4,7-8,12-13,15H,1-3,5-6,9-10,18H2,(H,19,20)/t13-,15-/m0/s1 YQQUNPLAHHFHOF-ZFWWWQNUSA-N 50310677 (S)-2-amino-N-((S)-1-cyano-2-cyclohexylethyl)-3-(thiophen-2-yl)propanamide::CHEMBL1080602 Dipeptidyl peptidase 1 5.1 ChEMBL 10.1016/j.bmcl.2009.07.114 10.7270/Q298874W 19665376 Guay, D; Beaulieu, C; Truchon, JF; Jagadeeswar Reddy, T; Zamboni, R; Bayly, CI; Methot, N; Rubin, J; Ethier, D; David Percival, M Merck Frosst Canada & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310677&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 46883426 104145038 CHEMBL1080602 ZINC49034300 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50558677 N[C@@H](Cc1cccs1)C(=O)N[C@@H](Cc1ccccc1)C#N InChI=1S/C16H17N3OS/c17-11-13(9-12-5-2-1-3-6-12)19-16(20)15(18)10-14-7-4-8-21-14/h1-8,13,15H,9-10,18H2,(H,19,20)/t13-,15-/m0/s1 RIPMAEFOLLJUOL-ZFWWWQNUSA-N 50310678 (S)-2-amino-N-((S)-1-cyano-2-phenylethyl)-3-(thiophen-2-yl)propanamide::CHEMBL1080780 Dipeptidyl peptidase 1 0.900000 ChEMBL 10.1016/j.bmcl.2009.07.114 10.7270/Q298874W 19665376 Guay, D; Beaulieu, C; Truchon, JF; Jagadeeswar Reddy, T; Zamboni, R; Bayly, CI; Methot, N; Rubin, J; Ethier, D; David Percival, M Merck Frosst Canada & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310678&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 46883427 104145039 CHEMBL1080780 ZINC49110208 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50558678 N[C@@H](Cc1cccs1)C(=O)N[C@@H](CCc1ccccc1)C#N InChI=1S/C17H19N3OS/c18-12-14(9-8-13-5-2-1-3-6-13)20-17(21)16(19)11-15-7-4-10-22-15/h1-7,10,14,16H,8-9,11,19H2,(H,20,21)/t14-,16-/m0/s1 BRVDRPWFUGZVRQ-HOCLYGCPSA-N 50310679 (S)-2-amino-N-((S)-1-cyano-3-phenylpropyl)-3-(thiophen-2-yl)propanamide::CHEMBL1080781 Dipeptidyl peptidase 1 11 ChEMBL 10.1016/j.bmcl.2009.07.114 10.7270/Q298874W 19665376 Guay, D; Beaulieu, C; Truchon, JF; Jagadeeswar Reddy, T; Zamboni, R; Bayly, CI; Methot, N; Rubin, J; Ethier, D; David Percival, M Merck Frosst Canada & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310679&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 46883428 104145040 CHEMBL1080781 ZINC49033762 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50558679 N[C@@H](Cc1cccs1)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C#N InChI=1S/C20H19N3OS/c21-13-17(23-20(24)19(22)12-18-6-3-9-25-18)11-14-7-8-15-4-1-2-5-16(15)10-14/h1-10,17,19H,11-12,22H2,(H,23,24)/t17-,19-/m0/s1 FFAORJHWGHHDFM-HKUYNNGSSA-N 50310680 (S)-2-amino-N-((S)-1-cyano-2-(naphthalen-2-yl)ethyl)-3-(thiophen-2-yl)propanamide::CHEMBL1081694 Dipeptidyl peptidase 1 1 ChEMBL 10.1016/j.bmcl.2009.07.114 10.7270/Q298874W 19665376 Guay, D; Beaulieu, C; Truchon, JF; Jagadeeswar Reddy, T; Zamboni, R; Bayly, CI; Methot, N; Rubin, J; Ethier, D; David Percival, M Merck Frosst Canada & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310680&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 46883429 104145041 CHEMBL1081694 ZINC49089668 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50558680 N[C@@H](Cc1cccs1)C(=O)N[C@@H](Cc1nc2ccccc2s1)C#N InChI=1S/C17H16N4OS2/c18-10-11(8-16-21-14-5-1-2-6-15(14)24-16)20-17(22)13(19)9-12-4-3-7-23-12/h1-7,11,13H,8-9,19H2,(H,20,22)/t11-,13-/m0/s1 VUPQZRKARVGQAL-AAEUAGOBSA-N 50310681 (S)-2-amino-N-((S)-2-(benzo[d]thiazol-2-yl)-1-cyanoethyl)-3-(thiophen-2-yl)propanamide::CHEMBL1081695 Dipeptidyl peptidase 1 0.700000 ChEMBL 10.1016/j.bmcl.2009.07.114 10.7270/Q298874W 19665376 Guay, D; Beaulieu, C; Truchon, JF; Jagadeeswar Reddy, T; Zamboni, R; Bayly, CI; Methot, N; Rubin, J; Ethier, D; David Percival, M Merck Frosst Canada & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310681&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 46883430 104145042 CHEMBL1081695 ZINC49034517 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50558681 N[C@@H](Cc1cccs1)C(=O)N[C@@H](Cc1ccc(s1)-c1ccccc1)C#N InChI=1S/C20H19N3OS2/c21-13-15(23-20(24)18(22)12-16-7-4-10-25-16)11-17-8-9-19(26-17)14-5-2-1-3-6-14/h1-10,15,18H,11-12,22H2,(H,23,24)/t15-,18-/m0/s1 BGLNHGYQNVKDBL-YJBOKZPZSA-N 50310682 (S)-2-amino-N-((S)-1-cyano-2-(5-phenylthiophen-2-yl)ethyl)-3-(thiophen-2-yl)propanamide::CHEMBL1079888 Dipeptidyl peptidase 1 0.300000 ChEMBL 10.1016/j.bmcl.2009.07.114 10.7270/Q298874W 19665376 Guay, D; Beaulieu, C; Truchon, JF; Jagadeeswar Reddy, T; Zamboni, R; Bayly, CI; Methot, N; Rubin, J; Ethier, D; David Percival, M Merck Frosst Canada & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310682&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 46883464 104145043 CHEMBL1079888 ZINC49032247 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50558682 CC(C)(C)[C@H](NC(=O)[C@@H](N)Cc1cccs1)C#N InChI=1S/C13H19N3OS/c1-13(2,3)11(8-14)16-12(17)10(15)7-9-5-4-6-18-9/h4-6,10-11H,7,15H2,1-3H3,(H,16,17)/t10-,11+/m0/s1 WLHICHWYBVIUAS-WDEREUQCSA-N 50310683 (S)-2-amino-N-((S)-1-cyano-2,2-dimethylpropyl)-3-(thiophen-2-yl)propanamide::CHEMBL1080605 Dipeptidyl peptidase 1 >3000 ChEMBL 10.1016/j.bmcl.2009.07.114 10.7270/Q298874W 19665376 Guay, D; Beaulieu, C; Truchon, JF; Jagadeeswar Reddy, T; Zamboni, R; Bayly, CI; Methot, N; Rubin, J; Ethier, D; David Percival, M Merck Frosst Canada & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310683&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 46883465 104145044 CHEMBL1080605 ZINC49034302 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50558683 N[C@@H](Cc1cccs1)C(=O)NC1(CC1)C#N InChI=1S/C11H13N3OS/c12-7-11(3-4-11)14-10(15)9(13)6-8-2-1-5-16-8/h1-2,5,9H,3-4,6,13H2,(H,14,15)/t9-/m0/s1 INBFODNGCPGUNU-VIFPVBQESA-N 50310684 (S)-2-amino-N-(1-cyanocyclopropyl)-3-(thiophen-2-yl)propanamide::CHEMBL1080606 Dipeptidyl peptidase 1 12 ChEMBL 10.1016/j.bmcl.2009.07.114 10.7270/Q298874W 19665376 Guay, D; Beaulieu, C; Truchon, JF; Jagadeeswar Reddy, T; Zamboni, R; Bayly, CI; Methot, N; Rubin, J; Ethier, D; David Percival, M Merck Frosst Canada & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310684 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310684&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 46883466 104145045 CHEMBL1080606 ZINC49033989 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50558684 CC(C)(NC(=O)[C@@H](N)Cc1cccs1)C#N InChI=1S/C11H15N3OS/c1-11(2,7-12)14-10(15)9(13)6-8-4-3-5-16-8/h3-5,9H,6,13H2,1-2H3,(H,14,15)/t9-/m0/s1 JHYOWNGKJGOKAX-VIFPVBQESA-N 50310685 (S)-2-amino-N-(2-cyanopropan-2-yl)-3-(thiophen-2-yl)propanamide::CHEMBL1080607 Dipeptidyl peptidase 1 1419 ChEMBL 10.1016/j.bmcl.2009.07.114 10.7270/Q298874W 19665376 Guay, D; Beaulieu, C; Truchon, JF; Jagadeeswar Reddy, T; Zamboni, R; Bayly, CI; Methot, N; Rubin, J; Ethier, D; David Percival, M Merck Frosst Canada & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310685 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310685&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 46883467 104145046 CHEMBL1080607 ZINC49032613 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50558685 N[C@@H](Cc1cccs1)C(=O)NC1(CCC1)C#N InChI=1S/C12H15N3OS/c13-8-12(4-2-5-12)15-11(16)10(14)7-9-3-1-6-17-9/h1,3,6,10H,2,4-5,7,14H2,(H,15,16)/t10-/m0/s1 FBEOUNUQLZYLAX-JTQLQIEISA-N 50310686 (S)-2-amino-N-(1-cyanocyclobutyl)-3-(thiophen-2-yl)propanamide::CHEMBL1080785 Dipeptidyl peptidase 1 1832 ChEMBL 10.1016/j.bmcl.2009.07.114 10.7270/Q298874W 19665376 Guay, D; Beaulieu, C; Truchon, JF; Jagadeeswar Reddy, T; Zamboni, R; Bayly, CI; Methot, N; Rubin, J; Ethier, D; David Percival, M Merck Frosst Canada & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310686 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310686&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 46883468 104145047 CHEMBL1080785 ZINC49033873 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50558686 CC1(C)CC1(NC(=O)[C@@H](N)Cc1cccs1)C#N InChI=1S/C13H17N3OS/c1-12(2)7-13(12,8-14)16-11(17)10(15)6-9-4-3-5-18-9/h3-5,10H,6-7,15H2,1-2H3,(H,16,17)/t10-,13?/m0/s1 STGNLSGQGNWRDX-NKUHCKNESA-N 50310687 (2S)-2-amino-N-(1-cyano-2,2-dimethylcyclopropyl)-3-(thiophen-2-yl)propanamide::CHEMBL1078313 Dipeptidyl peptidase 1 63 ChEMBL 10.1016/j.bmcl.2009.07.114 10.7270/Q298874W 19665376 Guay, D; Beaulieu, C; Truchon, JF; Jagadeeswar Reddy, T; Zamboni, R; Bayly, CI; Methot, N; Rubin, J; Ethier, D; David Percival, M Merck Frosst Canada & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310687 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310687&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 46883469 104145048 CHEMBL1078313 ZINC49112346 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50558687 N[C@@H](Cc1cccs1)C(=O)NC1(CC1c1ccccc1)C#N InChI=1S/C17H17N3OS/c18-11-17(10-14(17)12-5-2-1-3-6-12)20-16(21)15(19)9-13-7-4-8-22-13/h1-8,14-15H,9-10,19H2,(H,20,21)/t14?,15-,17?/m0/s1 FUYOZZGSCQXNCB-CKDBGZEDSA-N 50310688 CHEMBL1081148::trans-(+/-)-(2S)-2-amino-N-(1-cyano-2-phenylcyclopropyl)-3-(thiophen-2-yl)propanamide Dipeptidyl peptidase 1 1230 ChEMBL 10.1016/j.bmcl.2009.07.114 10.7270/Q298874W 19665376 Guay, D; Beaulieu, C; Truchon, JF; Jagadeeswar Reddy, T; Zamboni, R; Bayly, CI; Methot, N; Rubin, J; Ethier, D; David Percival, M Merck Frosst Canada & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310688 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310688&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 46883366 104145049 CHEMBL1081148 ZINC49032819 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50558688 N[C@@H](Cc1cccs1)C(=O)N[C@]1(C[C@H]1c1ccccc1)C#N InChI=1S/C17H17N3OS/c18-11-17(10-14(17)12-5-2-1-3-6-12)20-16(21)15(19)9-13-7-4-8-22-13/h1-8,14-15H,9-10,19H2,(H,20,21)/t14-,15-,17+/m0/s1 FUYOZZGSCQXNCB-YQQAZPJKSA-N 50310689 CHEMBL1080786::cis-(S)-2-amino-N-((1S,2S)-1-cyano-2-phenylcyclopropyl)-3-(thiophen-2-yl)propanamide Dipeptidyl peptidase 1 17 ChEMBL 10.1016/j.bmcl.2009.07.114 10.7270/Q298874W 19665376 Guay, D; Beaulieu, C; Truchon, JF; Jagadeeswar Reddy, T; Zamboni, R; Bayly, CI; Methot, N; Rubin, J; Ethier, D; David Percival, M Merck Frosst Canada & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310689 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310689&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 46883470 104145050 CHEMBL1080786 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50558689 N[C@@H](Cc1cccs1)C(=O)N[C@@]1(C[C@@H]1c1ccccc1)C#N InChI=1S/C17H17N3OS/c18-11-17(10-14(17)12-5-2-1-3-6-12)20-16(21)15(19)9-13-7-4-8-22-13/h1-8,14-15H,9-10,19H2,(H,20,21)/t14-,15+,17+/m1/s1 FUYOZZGSCQXNCB-VYDXJSESSA-N 50310690 CHEMBL1078411::Cis-(S)-2-amino-N-((1R,2R)-1-cyano-2-phenylcyclopropyl)-3-(thiophen-2-yl)propanamide Dipeptidyl peptidase 1 14 ChEMBL 10.1016/j.bmcl.2009.07.114 10.7270/Q298874W 19665376 Guay, D; Beaulieu, C; Truchon, JF; Jagadeeswar Reddy, T; Zamboni, R; Bayly, CI; Methot, N; Rubin, J; Ethier, D; David Percival, M Merck Frosst Canada & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310690&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 24822701 104145051 CHEMBL1078411 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50558690 O=C(N[C@@H](Cc1ccccc1)C#N)[C@@H]1CCCN1 InChI=1S/C14H17N3O/c15-10-12(9-11-5-2-1-3-6-11)17-14(18)13-7-4-8-16-13/h1-3,5-6,12-13,16H,4,7-9H2,(H,17,18)/t12-,13-/m0/s1 ONTXWGLODXXLKK-STQMWFEESA-N 50186092 (S)-N-((S)-1-cyano-2-phenylethyl)pyrrolidine-2-carboxamide::CHEMBL212514 Dipeptidyl peptidase 1 4806 ChEMBL 10.1016/j.bmcl.2009.07.114 10.7270/Q298874W 19665376 Guay, D; Beaulieu, C; Truchon, JF; Jagadeeswar Reddy, T; Zamboni, R; Bayly, CI; Methot, N; Rubin, J; Ethier, D; David Percival, M Merck Frosst Canada & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50186092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50186092&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 44413251 104070156 CHEMBL212514 ZINC36338746 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50558691 C[C@@H]1CN[C@@H](C1)C(=O)N[C@@H](Cc1ccccc1)C#N InChI=1S/C15H19N3O/c1-11-7-14(17-10-11)15(19)18-13(9-16)8-12-5-3-2-4-6-12/h2-6,11,13-14,17H,7-8,10H2,1H3,(H,18,19)/t11-,13-,14-/m0/s1 ZMSJONURFZIZTE-UBHSHLNASA-N 50310691 (2S,4S)-N-((S)-1-cyano-2-phenylethyl)-4-methylpyrrolidine-2-carboxamide::CHEMBL1079534 Dipeptidyl peptidase 1 2502 ChEMBL 10.1016/j.bmcl.2009.07.114 10.7270/Q298874W 19665376 Guay, D; Beaulieu, C; Truchon, JF; Jagadeeswar Reddy, T; Zamboni, R; Bayly, CI; Methot, N; Rubin, J; Ethier, D; David Percival, M Merck Frosst Canada & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310691 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310691&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 46883502 104145052 CHEMBL1079534 ZINC49032225 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50558692 CO[C@@H]1CN[C@@H](C1)C(=O)N[C@@H](Cc1ccccc1)C#N InChI=1S/C15H19N3O2/c1-20-13-8-14(17-10-13)15(19)18-12(9-16)7-11-5-3-2-4-6-11/h2-6,12-14,17H,7-8,10H2,1H3,(H,18,19)/t12-,13-,14-/m0/s1 LHTZOCLAJYTUCT-IHRRRGAJSA-N 50310692 (2S,4S)-N-((S)-1-cyano-2-phenylethyl)-4-methoxypyrrolidine-2-carboxamide::CHEMBL1079535 Dipeptidyl peptidase 1 1081 ChEMBL 10.1016/j.bmcl.2009.07.114 10.7270/Q298874W 19665376 Guay, D; Beaulieu, C; Truchon, JF; Jagadeeswar Reddy, T; Zamboni, R; Bayly, CI; Methot, N; Rubin, J; Ethier, D; David Percival, M Merck Frosst Canada & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310692&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 46883503 104145053 CHEMBL1079535 ZINC49110341 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50558693 Cl[C@@H]1CN[C@@H](C1)C(=O)N[C@@H](Cc1ccccc1)C#N InChI=1S/C14H16ClN3O/c15-11-7-13(17-9-11)14(19)18-12(8-16)6-10-4-2-1-3-5-10/h1-5,11-13,17H,6-7,9H2,(H,18,19)/t11-,12-,13-/m0/s1 LTFLNMAUBCHDEE-AVGNSLFASA-N 50310693 (2S,4S)-4-chloro-N-((S)-1-cyano-2-phenylethyl)pyrrolidine-2-carboxamide::CHEMBL1079536 Dipeptidyl peptidase 1 495 ChEMBL 10.1016/j.bmcl.2009.07.114 10.7270/Q298874W 19665376 Guay, D; Beaulieu, C; Truchon, JF; Jagadeeswar Reddy, T; Zamboni, R; Bayly, CI; Methot, N; Rubin, J; Ethier, D; David Percival, M Merck Frosst Canada & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310693&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 46883504 104145054 CHEMBL1079536 ZINC49032548 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50558694 F[C@@H]1CN[C@@H](C1)C(=O)N[C@@H](Cc1ccccc1)C#N InChI=1S/C14H16FN3O/c15-11-7-13(17-9-11)14(19)18-12(8-16)6-10-4-2-1-3-5-10/h1-5,11-13,17H,6-7,9H2,(H,18,19)/t11-,12-,13-/m0/s1 LVOZITWWHOYFCE-AVGNSLFASA-N 50310694 (2S,4S)-N-((S)-1-cyano-2-phenylethyl)-4-fluoropyrrolidine-2-carboxamide::CHEMBL1079537 Dipeptidyl peptidase 1 133 ChEMBL 10.1016/j.bmcl.2009.07.114 10.7270/Q298874W 19665376 Guay, D; Beaulieu, C; Truchon, JF; Jagadeeswar Reddy, T; Zamboni, R; Bayly, CI; Methot, N; Rubin, J; Ethier, D; David Percival, M Merck Frosst Canada & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310694 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310694&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 46883505 104145055 CHEMBL1079537 ZINC49032549 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50558695 Fc1ccc(C[C@H](NC(=O)[C@@H]2CCCN2)C#N)cc1 InChI=1S/C14H16FN3O/c15-11-5-3-10(4-6-11)8-12(9-16)18-14(19)13-2-1-7-17-13/h3-6,12-13,17H,1-2,7-8H2,(H,18,19)/t12-,13-/m0/s1 RMLPOSXGONZSBV-STQMWFEESA-N 50310695 (S)-N-((S)-1-cyano-2-(4-fluorophenyl)ethyl)pyrrolidine-2-carboxamide::CHEMBL1080251 Dipeptidyl peptidase 1 >10000 ChEMBL 10.1016/j.bmcl.2009.07.114 10.7270/Q298874W 19665376 Guay, D; Beaulieu, C; Truchon, JF; Jagadeeswar Reddy, T; Zamboni, R; Bayly, CI; Methot, N; Rubin, J; Ethier, D; David Percival, M Merck Frosst Canada & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310695 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310695&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 46883506 104145056 CHEMBL1080251 ZINC49033294 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50558696 CS[C@@H]1CN[C@@H](C1)C(=O)N[C@@H](Cc1ccccc1)C#N InChI=1S/C15H19N3OS/c1-20-13-8-14(17-10-13)15(19)18-12(9-16)7-11-5-3-2-4-6-11/h2-6,12-14,17H,7-8,10H2,1H3,(H,18,19)/t12-,13-,14-/m0/s1 INHIPGIGWGRJGP-IHRRRGAJSA-N 50310696 (2S,4S)-N-((S)-1-cyano-2-phenylethyl)-4-(methylthio)pyrrolidine-2-carboxamide::CHEMBL1081149 Dipeptidyl peptidase 1 29 ChEMBL 10.1016/j.bmcl.2009.07.114 10.7270/Q298874W 19665376 Guay, D; Beaulieu, C; Truchon, JF; Jagadeeswar Reddy, T; Zamboni, R; Bayly, CI; Methot, N; Rubin, J; Ethier, D; David Percival, M Merck Frosst Canada & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310696 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310696&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 46883367 104145057 CHEMBL1081149 ZINC49089735 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50558697 CSc1ccc(C[C@H](NC(=O)[C@@H]2CCCN2)C#N)cc1 InChI=1S/C15H19N3OS/c1-20-13-6-4-11(5-7-13)9-12(10-16)18-15(19)14-3-2-8-17-14/h4-7,12,14,17H,2-3,8-9H2,1H3,(H,18,19)/t12-,14-/m0/s1 RWJCMMQLIQESEK-JSGCOSHPSA-N 50310697 (S)-N-((S)-1-cyano-2-(4-(methylthio)phenyl)ethyl)pyrrolidine-2-carboxamide::CHEMBL1077746 Dipeptidyl peptidase 1 2545 ChEMBL 10.1016/j.bmcl.2009.07.114 10.7270/Q298874W 19665376 Guay, D; Beaulieu, C; Truchon, JF; Jagadeeswar Reddy, T; Zamboni, R; Bayly, CI; Methot, N; Rubin, J; Ethier, D; David Percival, M Merck Frosst Canada & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310697 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310697&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 46882864 104145058 CHEMBL1077746 ZINC48998433 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50558698 CCS[C@@H]1CN[C@@H](C1)C(=O)N[C@@H](Cc1ccccc1)C#N InChI=1S/C16H21N3OS/c1-2-21-14-9-15(18-11-14)16(20)19-13(10-17)8-12-6-4-3-5-7-12/h3-7,13-15,18H,2,8-9,11H2,1H3,(H,19,20)/t13-,14-,15-/m0/s1 WDIOLMZFWMAZKM-KKUMJFAQSA-N 50310698 (2S,4S)-N-((S)-1-cyano-2-phenylethyl)-4-(ethylthio)pyrrolidine-2-carboxamide::CHEMBL1078064 Dipeptidyl peptidase 1 271 ChEMBL 10.1016/j.bmcl.2009.07.114 10.7270/Q298874W 19665376 Guay, D; Beaulieu, C; Truchon, JF; Jagadeeswar Reddy, T; Zamboni, R; Bayly, CI; Methot, N; Rubin, J; Ethier, D; David Percival, M Merck Frosst Canada & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310698 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310698&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 46882865 104145059 CHEMBL1078064 ZINC49116088 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50558699 F[C@@]1(CN[C@@H](C1)C(=O)N[C@@H](Cc1ccccc1)C#N)c1ccccc1 InChI=1S/C20H20FN3O/c21-20(16-9-5-2-6-10-16)12-18(23-14-20)19(25)24-17(13-22)11-15-7-3-1-4-8-15/h1-10,17-18,23H,11-12,14H2,(H,24,25)/t17-,18-,20-/m0/s1 DVNLMXZGWUFTRG-BJLQDIEVSA-N 50310699 (2S,4R)-N-((S)-1-cyano-2-phenylethyl)-4-fluoro-4-phenylpyrrolidine-2-carboxamide::CHEMBL1078065 Dipeptidyl peptidase 1 8.2 ChEMBL 10.1016/j.bmcl.2009.07.114 10.7270/Q298874W 19665376 Guay, D; Beaulieu, C; Truchon, JF; Jagadeeswar Reddy, T; Zamboni, R; Bayly, CI; Methot, N; Rubin, J; Ethier, D; David Percival, M Merck Frosst Canada & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310699 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310699&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 46882866 104145060 CHEMBL1078065 ZINC48998445 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50558700 CS[C@@]1(CN[C@@H](C1)C(=O)N[C@@H](Cc1ccccc1)C#N)c1ccccc1 InChI=1S/C21H23N3OS/c1-26-21(17-10-6-3-7-11-17)13-19(23-15-21)20(25)24-18(14-22)12-16-8-4-2-5-9-16/h2-11,18-19,23H,12-13,15H2,1H3,(H,24,25)/t18-,19-,21-/m0/s1 TZBLNMJCFRIOTQ-ZJOUEHCJSA-N 50310700 (2S,4R)-N-((S)-1-cyano-2-phenylethyl)-4-(methylthio)-4-phenylpyrrolidine-2-carboxamide::CHEMBL1078066 Dipeptidyl peptidase 1 1.7 ChEMBL 10.1016/j.bmcl.2009.07.114 10.7270/Q298874W 19665376 Guay, D; Beaulieu, C; Truchon, JF; Jagadeeswar Reddy, T; Zamboni, R; Bayly, CI; Methot, N; Rubin, J; Ethier, D; David Percival, M Merck Frosst Canada & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310700 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310700&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 46882867 104145061 CHEMBL1078066 ZINC49112601 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50558701 F[C@@H]1CN[C@@H](C1)C(=O)NC1(CC1)C#N InChI=1S/C9H12FN3O/c10-6-3-7(12-4-6)8(14)13-9(5-11)1-2-9/h6-7,12H,1-4H2,(H,13,14)/t6-,7-/m0/s1 RMOKMHUGFOXWMB-BQBZGAKWSA-N 50310701 (2S,4S)-N-(1-cyanocyclopropyl)-4-fluoropyrrolidine-2-carboxamide::CHEMBL1077640 Dipeptidyl peptidase 1 880 ChEMBL 10.1016/j.bmcl.2009.07.114 10.7270/Q298874W 19665376 Guay, D; Beaulieu, C; Truchon, JF; Jagadeeswar Reddy, T; Zamboni, R; Bayly, CI; Methot, N; Rubin, J; Ethier, D; David Percival, M Merck Frosst Canada & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310701 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310701&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 46882868 104145062 CHEMBL1077640 ZINC48995278 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50558702 CS[C@@H]1CN[C@@H](C1)C(=O)NC1(CC1)C#N InChI=1S/C10H15N3OS/c1-15-7-4-8(12-5-7)9(14)13-10(6-11)2-3-10/h7-8,12H,2-5H2,1H3,(H,13,14)/t7-,8-/m0/s1 XHSDBDAODUWXLQ-YUMQZZPRSA-N 50310702 (2S,4S)-N-(1-cyanocyclopropyl)-4-(methylthio)pyrrolidine-2-carboxamide::CHEMBL1078067 Dipeptidyl peptidase 1 336 ChEMBL 10.1016/j.bmcl.2009.07.114 10.7270/Q298874W 19665376 Guay, D; Beaulieu, C; Truchon, JF; Jagadeeswar Reddy, T; Zamboni, R; Bayly, CI; Methot, N; Rubin, J; Ethier, D; David Percival, M Merck Frosst Canada & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310702 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310702&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 46882869 104145063 CHEMBL1078067 ZINC48998554 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50558703 F[C@@H]1CN[C@@H](C1)C(=O)N[C@]1(C[C@H]1c1ccccc1)C#N InChI=1S/C15H16FN3O/c16-11-6-13(18-8-11)14(20)19-15(9-17)7-12(15)10-4-2-1-3-5-10/h1-5,11-13,18H,6-8H2,(H,19,20)/t11-,12-,13-,15+/m0/s1 HVFTYIZBZCEIPF-PWNZVWSESA-N 50310703 (2S,4S)-N-((1S,2S)-1-cyano-2-phenylcyclopropyl)-4-fluoropyrrolidine-2-carboxamide::CHEMBL1078160 Dipeptidyl peptidase 1 2193 ChEMBL 10.1016/j.bmcl.2009.07.114 10.7270/Q298874W 19665376 Guay, D; Beaulieu, C; Truchon, JF; Jagadeeswar Reddy, T; Zamboni, R; Bayly, CI; Methot, N; Rubin, J; Ethier, D; David Percival, M Merck Frosst Canada & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310703 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310703&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 46882870 104145064 CHEMBL1078160 ZINC48999046 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50558705 F[C@@H]1CN[C@@H](C1)C(=O)NC1(CC1Cc1ccccc1)C#N InChI=1S/C16H18FN3O/c17-13-7-14(19-9-13)15(21)20-16(10-18)8-12(16)6-11-4-2-1-3-5-11/h1-5,12-14,19H,6-9H2,(H,20,21)/t12?,13-,14-,16?/m0/s1 YUWXKYWHTIMUMG-WJEHIRDRSA-N 50310704 CHEMBL1078356::Cis-(2S,4S)-N-(2-benzyl-1-cyanocyclopropyl)-4-fluoropyrrolidine-2-carboxamide Dipeptidyl peptidase 1 523 ChEMBL 10.1016/j.bmcl.2009.07.114 10.7270/Q298874W 19665376 Guay, D; Beaulieu, C; Truchon, JF; Jagadeeswar Reddy, T; Zamboni, R; Bayly, CI; Methot, N; Rubin, J; Ethier, D; David Percival, M Merck Frosst Canada & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310704 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310704&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 46882914 104145065 CHEMBL1078356 ZINC49014073 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50558707 CS[C@@H]1CN[C@@H](C1)C(=O)NC1(CC1Cc1ccccc1)C#N InChI=1S/C17H21N3OS/c1-22-14-8-15(19-10-14)16(21)20-17(11-18)9-13(17)7-12-5-3-2-4-6-12/h2-6,13-15,19H,7-10H2,1H3,(H,20,21)/t13?,14-,15-,17?/m0/s1 XSOLZYSVIWKGHX-GWUWNPHMSA-N 50310705 CHEMBL1077666::Cis-(2S,4S)-N-(2-benzyl-1-cyanocyclopropyl)-4-(methylthio)pyrrolidine-2-carboxamide Dipeptidyl peptidase 1 192 ChEMBL 10.1016/j.bmcl.2009.07.114 10.7270/Q298874W 19665376 Guay, D; Beaulieu, C; Truchon, JF; Jagadeeswar Reddy, T; Zamboni, R; Bayly, CI; Methot, N; Rubin, J; Ethier, D; David Percival, M Merck Frosst Canada & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310705 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310705&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 46882915 104145066 CHEMBL1077666 ZINC48999403 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500445 CS(C)(=O)=Nc1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H27FN4O2S/c1-32(2,31)29-20-5-3-4-15(10-20)16-6-7-17(22(25)13-16)11-21(14-26)28-24(30)23-18-8-9-19(12-18)27-23/h3-7,10,13,18-19,21,23,27H,8-9,11-12H2,1-2H3,(H,28,30)/t18-,19+,21-,23-/m0/s1 IUJZTLDIIDKLJO-QRICJDHISA-N 150585 US10238633, Example 259::US8987249, 259::US9713606, 259 Dipeptidyl peptidase 1 6.00 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150585 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150585&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430810 252824836 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500446 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnn(C[C@H]2CCCO2)c1 InChI=1S/C24H28FN5O2/c25-22-10-15(18-12-27-30(13-18)14-21-2-1-7-32-21)3-4-16(22)8-20(11-26)29-24(31)23-17-5-6-19(9-17)28-23/h3-4,10,12-13,17,19-21,23,28H,1-2,5-9,14H2,(H,29,31)/t17-,19+,20-,21+,23-/m0/s1 HMZMPMLDAMDPBI-YMBXHIRXSA-N 150586 US10238633, Example 260::US8987249, 260::US9713606, 260 Dipeptidyl peptidase 1 3.50 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150586 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150586&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430801 252824837 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500447 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnn(C[C@@H]2CCCO2)c1 InChI=1S/C24H28FN5O2/c25-22-10-15(18-12-27-30(13-18)14-21-2-1-7-32-21)3-4-16(22)8-20(11-26)29-24(31)23-17-5-6-19(9-17)28-23/h3-4,10,12-13,17,19-21,23,28H,1-2,5-9,14H2,(H,29,31)/t17-,19+,20-,21-,23-/m0/s1 HMZMPMLDAMDPBI-NROJZILJSA-N 150587 US10238633, Example 261::US8987249, 261::US9713606, 261 Dipeptidyl peptidase 1 4.20 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150587 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150587&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430756 252824838 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500448 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnn(C[C@@H]2CCOC2)c1 InChI=1S/C24H28FN5O2/c25-22-9-16(19-11-27-30(13-19)12-15-5-6-32-14-15)1-2-17(22)7-21(10-26)29-24(31)23-18-3-4-20(8-18)28-23/h1-2,9,11,13,15,18,20-21,23,28H,3-8,12,14H2,(H,29,31)/t15-,18-,20+,21-,23-/m0/s1 CWXBPKJABGXNSH-WNZZMIDNSA-N 150588 US10238633, Example 262::US8987249, 262::US9713606, 262 Dipeptidyl peptidase 1 6.40 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150588 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150588&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430757 252824839 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500449 CS(=O)(=NC#N)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H24FN5O2S/c1-33(32,28-14-27)21-8-5-15(6-9-21)16-2-3-17(22(25)12-16)10-20(13-26)30-24(31)23-18-4-7-19(11-18)29-23/h2-3,5-6,8-9,12,18-20,23,29H,4,7,10-11H2,1H3,(H,30,31)/t18-,19+,20-,23-,33?/m0/s1 JMXAQAKZQYJMRJ-PVEGDPQMSA-N 150589 US10238633, Example 263::US8987249, 263::US9713606, 263 Dipeptidyl peptidase 1 11.8 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150589&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430784 252824840 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500451 CS(=O)c1cc(=O)n(cc1F)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H22F2N4O3S/c1-32(31)19-9-20(29)28(11-18(19)24)16-5-3-12(17(23)8-16)6-15(10-25)27-22(30)21-13-2-4-14(7-13)26-21/h3,5,8-9,11,13-15,21,26H,2,4,6-7H2,1H3,(H,27,30)/t13-,14+,15-,21-,32?/m0/s1 CVPOOVIOJPARFP-LDEKDMLCSA-N 150591 US10238633, Example 265::US8987249, 265::US9713606, 265 Dipeptidyl peptidase 1 62.7 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150591 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150591&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430867 252824842 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50853708 CC(C)(F)C[C@H](N[C@@H](c1ccc(cc1)-c1ccc(cc1)S(C)(=O)=O)C(F)(F)F)C(=O)NC1(CC1)C#N InChI=1S/C25H27F4N3O3S/c1-23(2,26)14-20(22(33)32-24(15-30)12-13-24)31-21(25(27,28)29)18-6-4-16(5-7-18)17-8-10-19(11-9-17)36(3,34)35/h4-11,20-21,31H,12-14H2,1-3H3,(H,32,33)/t20-,21-/m0/s1 FWIVDMJALNEADT-SFTDATJTSA-N 50255753 CHEMBL481611::MK-0822::Odanacatib Dipeptidyl peptidase 1 >10 ChEMBL 10.1016/j.bmcl.2007.12.047 10.7270/Q21J9BM2 18226527 Gauthier, JY; Chauret, N; Cromlish, W; Desmarais, S; Duong, le T; Falgueyret, JP; Kimmel, DB; Lamontagne, S; Leger, S; LeRiche, T; Li, CS; Masse, F; McKay, DJ; Nicoll-Griffith, DA; Oballa, RM; Palmer, JT; Percival, MD; Riendeau, D; Robichaud, J; Rodan, GA; Rodan, SB; Seto, C; Therien, M; Truong, VL; Venuti, MC; Wesolowski, G; Young, RN; Zamboni, R; Black, WC Merck Frosst Centre for Therapeutic Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50255753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50255753&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 10152654 104107486 CHEMBL481611 6478 ZINC42893657 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50871966 NCC(=O)N[C@@H](Cc1ccccc1)C(=O)[CH-][N+]#N InChI=1S/C12H14N4O2/c13-7-12(18)16-10(11(17)8-15-14)6-9-4-2-1-3-5-9/h1-5,8,10H,6-7,13H2,(H,16,18)/t10-/m0/s1 CBOIZHHBFFTMCQ-JTQLQIEISA-N 50270030 2-Amino-N-((S)-1-benzyl-3-diazo-2-oxo-propyl)-acetamide::CHEMBL448143 Dipeptidyl peptidase 1 51 ChEMBL 10.1074/jbc.M702615200 10.7270/Q2125TJM 17535802 Methot, N; Rubin, J; Guay, D; Beaulieu, C; Ethier, D; Reddy, TJ; Riendeau, D; Percival, MD Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50270030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50270030&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 44584933 104115409 CHEMBL448143 ZINC13519194 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50871970 [NH3+][C@H](Cc1cccs1)C(=O)N[C@]1(C[C@H]1c1ccccc1)C#N InChI=1S/C17H17N3OS/c18-11-17(10-14(17)12-5-2-1-3-6-12)20-16(21)15(19)9-13-7-4-8-22-13/h1-8,14-15H,9-10,19H2,(H,20,21)/p+1/t14-,15+,17+/m0/s1 FUYOZZGSCQXNCB-ZMSDIMECSA-O 50270039 (S)-1-((1S,2S)-1-cyano-2-phenylcyclopropylamino)-1-oxo-3-(thiophen-2-yl)propan-2-aminium 2,2,2-trifluoroacetate::CHEMBL478737 Dipeptidyl peptidase 1 >30000 ChEMBL 10.1074/jbc.M702615200 10.7270/Q2125TJM 17535802 Methot, N; Rubin, J; Guay, D; Beaulieu, C; Ethier, D; Reddy, TJ; Riendeau, D; Percival, MD Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50270039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50270039&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91935166 104115411 CHEMBL478737 ZINC40917110 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50871971 [NH3+][C@@H](Cc1cccs1)C(=O)N[C@@]1(C[C@@H]1c1ccccc1)C#N InChI=1S/C17H17N3OS/c18-11-17(10-14(17)12-5-2-1-3-6-12)20-16(21)15(19)9-13-7-4-8-22-13/h1-8,14-15H,9-10,19H2,(H,20,21)/p+1/t14-,15+,17+/m1/s1 FUYOZZGSCQXNCB-VYDXJSESSA-O 50270040 (S)-1-((1R,2R)-1-cyano-2-phenylcyclopropylamino)-1-oxo-3-(thiophen-2-yl)propan-2-aminium 2,2,2-trifluoroacetate::CHEMBL516292 Dipeptidyl peptidase 1 14 ChEMBL 10.1074/jbc.M702615200 10.7270/Q2125TJM 17535802 Methot, N; Rubin, J; Guay, D; Beaulieu, C; Ethier, D; Reddy, TJ; Riendeau, D; Percival, MD Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50270040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50270040&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91935167 104115412 CHEMBL516292 ZINC40404481 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50871972 CC(C)C[C@@H](NC(=O)N1CCOCC1)C(=O)N[C@H](CCc1ccccc1)C=CS(=O)(=O)c1ccccc1 InChI=1S/C28H37N3O5S/c1-22(2)21-26(30-28(33)31-16-18-36-19-17-31)27(32)29-24(14-13-23-9-5-3-6-10-23)15-20-37(34,35)25-11-7-4-8-12-25/h3-12,15,20,22,24,26H,13-14,16-19,21H2,1-2H3,(H,29,32)(H,30,33)/t24-,26-/m1/s1 YUMYYTORLYHUFW-AOYPEHQESA-N 19516 (2S)-N-[(3S,5E)-6-(benzenesulfonyl)-4-oxo-1-phenylhex-5-en-3-yl]-4-methyl-2-(morpholin-4-ylcarbonylamino)pentanamide::CHEMBL222649::LHVS::Morpholinurea-Leu-Hph-Vinyl-Sulfone-Phenyl::Morpholinurea-Leucine-Homophenylalaninevinyl Phenyl Sulfone Dipeptidyl peptidase 1 >10000 ChEMBL 10.1074/jbc.M702615200 10.7270/Q2125TJM 17535802 Methot, N; Rubin, J; Guay, D; Beaulieu, C; Ethier, D; Reddy, TJ; Riendeau, D; Percival, MD Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19516 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=19516&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1NPZ,3BWK 23648296 46519531 CHEMBL222649 ZINC12503958 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50871974 CCC[C@H](NC(=O)C(CC(C)C)NC(=O)c1ccc(cc1)-c1ccc(I)cc1)C(=O)[CH-][N+]#N InChI=1S/C25H29IN4O3/c1-4-5-21(23(31)15-28-27)29-25(33)22(14-16(2)3)30-24(32)19-8-6-17(7-9-19)18-10-12-20(26)13-11-18/h6-13,15-16,21-22H,4-5,14H2,1-3H3,(H,29,33)(H,30,32)/t21-,22?/m0/s1 VHNVOAVIDBRLFO-HMTLIYDFSA-N 50270041 4'-Iodo-biphenyl-4-carboxylic acid {1-[(S)-1-(2-diazo-acetyl)-butylcarbamoyl]-3-methyl-butyl}-amide::CHEMBL518284 Dipeptidyl peptidase 1 450 ChEMBL 10.1074/jbc.M702615200 10.7270/Q2125TJM 17535802 Methot, N; Rubin, J; Guay, D; Beaulieu, C; Ethier, D; Reddy, TJ; Riendeau, D; Percival, MD Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50270041 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50270041&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 44584942 104115413 CHEMBL518284 ZINC42876138 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50871975 NCC(=O)N[C@@H](Cc1ccc(I)cc1)C(=O)[CH-][N+]#N InChI=1S/C12H13IN4O2/c13-9-3-1-8(2-4-9)5-10(11(18)7-16-15)17-12(19)6-14/h1-4,7,10H,5-6,14H2,(H,17,19)/t10-/m0/s1 IVMLSILVSGOWGN-JTQLQIEISA-N 50270029 2-Amino-N-[(S)-3-diazo-1-(4-iodo-benzyl)-2-oxo-propyl]-acetamide::CHEMBL450997 Dipeptidyl peptidase 1 1 ChEMBL 10.1074/jbc.M702615200 10.7270/Q2125TJM 17535802 Methot, N; Rubin, J; Guay, D; Beaulieu, C; Ethier, D; Reddy, TJ; Riendeau, D; Percival, MD Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50270029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50270029&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 44584931 104115408 CHEMBL450997 ZINC40980476 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50872016 CS(=O)(=O)C[C@H](N[C@@H](c1ccc(Br)cc1)C(F)(F)F)C(=O)NC1(CC1)C#N InChI=1S/C16H17BrF3N3O3S/c1-27(25,26)8-12(14(24)23-15(9-21)6-7-15)22-13(16(18,19)20)10-2-4-11(17)5-3-10/h2-5,12-13,22H,6-8H2,1H3,(H,23,24)/t12-,13-/m0/s1 QHDGGHMKRWZOAZ-STQMWFEESA-N 19492 (2R)-2-{[(1S)-1-(4-bromophenyl)-2,2,2-trifluoroethyl]amino}-N-(1-cyanocyclopropyl)-3-methanesulfonylpropanamide::CHEMBL400387::trifluoroethylamine inhibitor, 2 Dipeptidyl peptidase 1 >10000 ChEMBL 10.1074/jbc.M702615200 10.7270/Q2125TJM 17535802 Methot, N; Rubin, J; Guay, D; Beaulieu, C; Ethier, D; Reddy, TJ; Riendeau, D; Percival, MD Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19492 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=19492&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 23648277 46519507 CHEMBL400387 ZINC14971100 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50872017 [NH3+]C(Cc1c[nH+]cs1)C(=O)N[C@]1(C[C@H]1c1ccccc1)C#N InChI=1S/C16H16N4OS/c17-9-16(7-13(16)11-4-2-1-3-5-11)20-15(21)14(18)6-12-8-19-10-22-12/h1-5,8,10,13-14H,6-7,18H2,(H,20,21)/p+2/t13-,14?,16+/m0/s1 ZDIWELBONJHKGV-XWDNMSNZSA-P 50269859 2,2,2-trifluoroacetate; 5-(2-azaniumyl-2-{[(1S,2S)-1-cyano-2-phenylcyclopropyl]carbamoyl}ethyl)-1,3-thiazol-3-ium Dipeptidyl peptidase 1 790 ChEMBL 10.1074/jbc.M702615200 10.7270/Q2125TJM 17535802 Methot, N; Rubin, J; Guay, D; Beaulieu, C; Ethier, D; Reddy, TJ; Riendeau, D; Percival, MD Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50269859 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50269859&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91935160 104115291 ZINC40980170 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50872018 [NH3+][C@@H](Cc1ccccc1F)C(=O)N[C@]1(C[C@H]1c1ccccc1)C#N InChI=1S/C19H18FN3O/c20-16-9-5-4-8-14(16)10-17(22)18(24)23-19(12-21)11-15(19)13-6-2-1-3-7-13/h1-9,15,17H,10-11,22H2,(H,23,24)/p+1/t15-,17-,19+/m0/s1 XIMJYDLECPMKMN-VDZJLULYSA-O 50269858 Trifluoro-acetate(S)-1-((1S,2S)-1-cyano-2-phenyl-cyclopropylcarbamoyl)-2-(2-fluoro-phenyl)-ethyl-ammonium Dipeptidyl peptidase 1 >220 ChEMBL 10.1074/jbc.M702615200 10.7270/Q2125TJM 17535802 Methot, N; Rubin, J; Guay, D; Beaulieu, C; Ethier, D; Reddy, TJ; Riendeau, D; Percival, MD Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50269858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50269858&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91935159 104115290 ZINC40979434 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500454 CC(C)(C)N1CCN(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H34FN5O/c1-24(2,3)30-10-8-29(9-11-30)20-7-5-16(21(25)14-20)12-19(15-26)28-23(31)22-17-4-6-18(13-17)27-22/h5,7,14,17-19,22,27H,4,6,8-13H2,1-3H3,(H,28,31)/t17-,18+,19-,22-/m0/s1 GZNWGNOSEGSJHK-WEMPKCCASA-N 150594 US10238633, Example 268::US8987249, 268::US9713606, 268 Dipeptidyl peptidase 1 11.1 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150594 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150594&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430444 252824845 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500455 CO[C@@H]1C[C@@H]2CN(CCN2C1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H32FN5O2/c1-32-21-10-20-13-29(6-7-30(20)14-21)19-5-3-15(22(25)11-19)8-18(12-26)28-24(31)23-16-2-4-17(9-16)27-23/h3,5,11,16-18,20-21,23,27H,2,4,6-10,13-14H2,1H3,(H,28,31)/t16-,17+,18-,20+,21+,23-/m0/s1 VIAZGHFEVYETOO-RWYQBMLRSA-N 150595 US10238633, Example 269::US8987249, 269::US9713606, 269 Dipeptidyl peptidase 1 9.40 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150595 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150595&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430423 252824846 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500456 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCN2CCC[C@H]2C1 InChI=1S/C23H30FN5O/c24-21-12-19(29-9-8-28-7-1-2-20(28)14-29)6-4-15(21)10-18(13-25)27-23(30)22-16-3-5-17(11-16)26-22/h4,6,12,16-18,20,22,26H,1-3,5,7-11,14H2,(H,27,30)/t16-,17+,18-,20-,22-/m0/s1 HLJGWEHAZHBPGN-FFUNNMLOSA-N 150596 US10238633, Example 270::US8987249, 270::US9713606, 270 Dipeptidyl peptidase 1 6.30 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150596 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150596&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430398 252824847 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500457 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCCN2CCCC2C1 InChI=1S/C24H32FN5O/c25-22-13-20(30-10-2-9-29-8-1-3-21(29)15-30)7-5-16(22)11-19(14-26)28-24(31)23-17-4-6-18(12-17)27-23/h5,7,13,17-19,21,23,27H,1-4,6,8-12,15H2,(H,28,31)/t17-,18+,19-,21?,23-/m0/s1 LEQJDFRTVFEHSE-BRJVMOAUSA-N 150597 US10238633, Example 271::US8987249, 271::US9713606, 271 Dipeptidyl peptidase 1 5.90 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150597&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430445 252824848 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500458 CCN1CCN(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H30FN5O/c1-2-27-7-9-28(10-8-27)19-6-4-15(20(23)13-19)11-18(14-24)26-22(29)21-16-3-5-17(12-16)25-21/h4,6,13,16-18,21,25H,2-3,5,7-12H2,1H3,(H,26,29)/t16-,17+,18-,21-/m0/s1 OQJKHSTWNPGKCN-NYUBLWNDSA-N 150598 US10238633, Example 272::US8987249, 272::US9713606, 272 Dipeptidyl peptidase 1 6.80 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150598&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430648 252824849 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500459 CCc1cc(nn1CC(C)C)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C25H32FN5O/c1-4-21-12-23(30-31(21)14-15(2)3)17-6-5-16(22(26)11-17)9-20(13-27)29-25(32)24-18-7-8-19(10-18)28-24/h5-6,11-12,15,18-20,24,28H,4,7-10,14H2,1-3H3,(H,29,32)/t18-,19+,20-,24-/m0/s1 QKCJEPXSJFAOTH-VKDGWMQASA-N 150599 US10238633, Example 273::US8987249, 273::US9713606, 273 Dipeptidyl peptidase 1 28.9 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150599 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150599&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430659 252824850 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50905144 COC(=O)[C@@H]1CCCN1C(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@H](C)NC(=O)[C@@H](NC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](OC(=O)[C@@H](OC(=O)[C@H](C(C)C)N(C)C)C(C)C)C(C)C)[C@@H](C)O InChI=1S/C58H95N9O16/c1-30(2)25-38(43(69)29-45(71)64-46(36(12)68)52(74)60-35(11)54(76)66(15)42(27-37-21-18-17-19-22-37)55(77)67-24-20-23-41(67)56(78)81-16)61-51(73)40(28-44(59)70)62-50(72)39(26-31(3)4)63-53(75)48(33(7)8)82-58(80)49(34(9)10)83-57(79)47(32(5)6)65(13)14/h17-19,21-22,30-36,38-43,46-49,68-69H,20,23-29H2,1-16H3,(H2,59,70)(H,60,74)(H,61,73)(H,62,72)(H,63,75)(H,64,71)/t35-,36+,38-,39-,40-,41-,42+,43-,46-,47-,48+,49-/m0/s1 JZYWSTGTBRHGTL-BIXXXADNSA-N 50302107 CHEMBL567893::Grassystatin A Dipeptidyl peptidase 1 10000 ChEMBL 10.1021/jm9009394 10.7270/Q2BG2PXP 19715320 Kwan, JC; Eksioglu, EA; Liu, C; Paul, VJ; Luesch, H University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50302107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50302107&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 44255320 104156468 CHEMBL567893 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500461 CCOc1cc(cc(c1)S(C)(=O)=O)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C25H28FN3O4S/c1-3-33-21-10-18(11-22(13-21)34(2,31)32)15-4-5-16(23(26)12-15)8-20(14-27)29-25(30)24-17-6-7-19(9-17)28-24/h4-5,10-13,17,19-20,24,28H,3,6-9H2,1-2H3,(H,29,30)/t17-,19+,20-,24-/m0/s1 YXBZSIUIDAWIIE-GHCZAOPSSA-N 150601 US10238633, Example 275::US8987249, 275::US9713606, 275 Dipeptidyl peptidase 1 33.0 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150601 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150601&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430649 252824852 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500462 CS(=O)(=O)c1cc(OCC(F)(F)F)cc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C25H25F4N3O4S/c1-37(34,35)21-9-17(8-20(11-21)36-13-25(27,28)29)14-2-3-15(22(26)10-14)6-19(12-30)32-24(33)23-16-4-5-18(7-16)31-23/h2-3,8-11,16,18-19,23,31H,4-7,13H2,1H3,(H,32,33)/t16-,18+,19-,23-/m0/s1 NOGUIGWOYFVCHA-FAODYONGSA-N 150602 US10238633, Example 276::US8987249, 276::US9713606, 276 Dipeptidyl peptidase 1 14.1 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150602&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430821 252824853 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500463 CN(C)CCCN1C(=O)Cc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C29H34FN5O2/c1-34(2)10-3-11-35-26-15-19(5-7-21(26)16-27(35)36)18-4-6-20(25(30)14-18)12-24(17-31)33-29(37)28-22-8-9-23(13-22)32-28/h4-7,14-15,22-24,28,32H,3,8-13,16H2,1-2H3,(H,33,37)/t22-,23+,24-,28-/m0/s1 XVWGIESADAKPIF-IMBSWCNGSA-N 150603 US10238633, Example 277::US8987249, 277::US9713606, 277 Dipeptidyl peptidase 1 3.00 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150603 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150603&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443263 252824854 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500464 CN(C)CCN1C(=O)Cc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C28H32FN5O2/c1-33(2)9-10-34-25-14-18(4-6-20(25)15-26(34)35)17-3-5-19(24(29)13-17)11-23(16-30)32-28(36)27-21-7-8-22(12-21)31-27/h3-6,13-14,21-23,27,31H,7-12,15H2,1-2H3,(H,32,36)/t21-,22+,23-,27-/m0/s1 AWNMFDZAZNAOSJ-GIRPNKPCSA-N 150604 US10238633, Example 278::US8987249, 278::US9713606, 278 Dipeptidyl peptidase 1 1.000 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150604 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150604&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430474 252824855 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500465 CN(C)CCN1C(=O)Cc2cc(ccc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C28H32FN5O2/c1-33(2)9-10-34-25-8-6-17(11-21(25)15-26(34)35)18-3-4-19(24(29)14-18)12-23(16-30)32-28(36)27-20-5-7-22(13-20)31-27/h3-4,6,8,11,14,20,22-23,27,31H,5,7,9-10,12-13,15H2,1-2H3,(H,32,36)/t20-,22+,23-,27-/m0/s1 NPDKQIXUJNALPW-XUTUTRJZSA-N 150605 US10238633, Example 279::US8987249, 279::US9713606, 279 Dipeptidyl peptidase 1 5.50 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150605 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150605&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430478 252824856 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500466 CC(C)N1CCC(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H33FN4O/c1-15(2)29-9-7-16(8-10-29)17-3-4-18(22(25)13-17)11-21(14-26)28-24(30)23-19-5-6-20(12-19)27-23/h3-4,13,15-16,19-21,23,27H,5-12H2,1-2H3,(H,28,30)/t19-,20+,21-,23-/m0/s1 VJGDLRYVNAZRGF-KGSLCBSSSA-N 150606 US10238633, Example 280::US8987249, 280::US9713606, 280 Dipeptidyl peptidase 1 21.2 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150606 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150606&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430473 252824857 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500467 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)C1=CCN2CCOCC2C1 InChI=1S/C24H29FN4O2/c25-22-12-15(16-5-6-29-7-8-31-14-21(29)11-16)1-2-17(22)9-20(13-26)28-24(30)23-18-3-4-19(10-18)27-23/h1-2,5,12,18-21,23,27H,3-4,6-11,14H2,(H,28,30)/t18-,19+,20-,21?,23-/m0/s1 CMFKDMUAZSMZET-SIKKGAFYSA-N 150607 US10238633, Example 281::US8987249, 281::US9713606, 281 Dipeptidyl peptidase 1 3.30 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150607 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150607&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430479 252824858 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500468 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)C1=CC2COCCN2CC1 InChI=1S/C24H29FN4O2/c25-22-12-15(16-5-6-29-7-8-31-14-21(29)11-16)1-2-17(22)9-20(13-26)28-24(30)23-18-3-4-19(10-18)27-23/h1-2,11-12,18-21,23,27H,3-10,14H2,(H,28,30)/t18-,19+,20-,21?,23-/m0/s1 KYHQETISGYHVCF-SIKKGAFYSA-N 150608 US10238633, Example 282::US8987249, 282::US9713606, 282 Dipeptidyl peptidase 1 3.70 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150608&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430481 252824859 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500469 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)[C@@H]1CCN2CCOC[C@H]2C1 InChI=1S/C24H31FN4O2/c25-22-12-15(16-5-6-29-7-8-31-14-21(29)11-16)1-2-17(22)9-20(13-26)28-24(30)23-18-3-4-19(10-18)27-23/h1-2,12,16,18-21,23,27H,3-11,14H2,(H,28,30)/t16-,18+,19-,20+,21-,23+/m1/s1 UVMGBTLVJPDNFH-IXRJDROYSA-N 150609 US10238633, Example 283::US8987249, 283::US9713606, 283 Dipeptidyl peptidase 1 9.70 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150609 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150609&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430740 252824860 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500470 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)[C@H]1CCN2CCOC[C@H]2C1 InChI=1S/C24H31FN4O2/c25-22-12-15(16-5-6-29-7-8-31-14-21(29)11-16)1-2-17(22)9-20(13-26)28-24(30)23-18-3-4-19(10-18)27-23/h1-2,12,16,18-21,23,27H,3-11,14H2,(H,28,30)/t16-,18-,19+,20-,21+,23-/m0/s1 UVMGBTLVJPDNFH-LYAMXQPKSA-N 150610 US10238633, Example 284::US8987249, 284::US9713606, 284 Dipeptidyl peptidase 1 13.8 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150610 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150610&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430753 252824861 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500471 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-n1cc(cn1)C(F)(F)F InChI=1S/C20H19F4N5O/c21-17-7-16(29-10-13(9-26-29)20(22,23)24)4-2-11(17)5-15(8-25)28-19(30)18-12-1-3-14(6-12)27-18/h2,4,7,9-10,12,14-15,18,27H,1,3,5-6H2,(H,28,30)/t12-,14+,15-,18-/m0/s1 KLUIZDATHDMRJM-OGIUKLMXSA-N 150611 US10238633, Example 285::US8987249, 285::US9713606, 285 Dipeptidyl peptidase 1 9.30 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150611 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150611&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430861 252824862 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500472 CN(C)C(=O)c1cnn(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H25FN6O2/c1-28(2)22(31)15-11-25-29(12-15)18-6-4-13(19(23)9-18)7-17(10-24)27-21(30)20-14-3-5-16(8-14)26-20/h4,6,9,11-12,14,16-17,20,26H,3,5,7-8H2,1-2H3,(H,27,30)/t14-,16+,17-,20-/m0/s1 ADLODPBTXCWQIJ-FORWCCJISA-N 150612 US10238633, Example 286::US8987249, 286::US9713606, 286 Dipeptidyl peptidase 1 38.9 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150612 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150612&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430862 252824863 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500473 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-n1cc(cn1)C(=O)N1CCOCC1 InChI=1S/C24H27FN6O3/c25-21-11-20(31-14-17(13-27-31)24(33)30-5-7-34-8-6-30)4-2-15(21)9-19(12-26)29-23(32)22-16-1-3-18(10-16)28-22/h2,4,11,13-14,16,18-19,22,28H,1,3,5-10H2,(H,29,32)/t16-,18+,19-,22-/m0/s1 PUDLCFJOVIUEHT-ZBPHCFQXSA-N 150613 US10238633, Example 287::US8987249, 287::US9713606, 287 Dipeptidyl peptidase 1 39.7 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150613 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150613&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430863 252824864 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500474 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc(o1)C(=O)N1CCOCC1 InChI=1S/C25H27FN4O4/c26-20-13-16(21-5-6-22(34-21)25(32)30-7-9-33-10-8-30)2-1-15(20)11-19(14-27)29-24(31)23-17-3-4-18(12-17)28-23/h1-2,5-6,13,17-19,23,28H,3-4,7-12H2,(H,29,31)/t17-,18+,19-,23-/m0/s1 QLIQIELZFMSNMZ-YWNPBTLJSA-N 150614 US10238633, Example 288::US8987249, 288::US9713606, 288 Dipeptidyl peptidase 1 2.30 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150614 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150614&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430829 252824865 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500475 CN1CCN(CC1)C(=O)c1ccc(o1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C26H30FN5O3/c1-31-8-10-32(11-9-31)26(34)23-7-6-22(35-23)17-3-2-16(21(27)14-17)12-20(15-28)30-25(33)24-18-4-5-19(13-18)29-24/h2-3,6-7,14,18-20,24,29H,4-5,8-13H2,1H3,(H,30,33)/t18-,19+,20-,24-/m0/s1 WONAWGLRVBZQLT-VKDGWMQASA-N 150615 US10238633, Example 289::US8987249, 289::US9713606, 289 Dipeptidyl peptidase 1 2.50 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150615 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150615&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443284 252824866 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500476 Fc1cc(OCc2ccccc2)ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N InChI=1S/C23H24FN3O2/c24-21-12-20(29-14-15-4-2-1-3-5-15)9-7-16(21)10-19(13-25)27-23(28)22-17-6-8-18(11-17)26-22/h1-5,7,9,12,17-19,22,26H,6,8,10-11,14H2,(H,27,28)/t17-,18+,19-,22-/m0/s1 ODYJNVQNAFLEJI-WEMPKCCASA-N 150616 US10238633, Example 290::US8987249, 290::US9713606, 290 Dipeptidyl peptidase 1 20.6 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150616 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150616&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430850 252824867 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500477 NC(=O)c1cc(F)c2[nH]c(=O)c3cc(CC(NC(=O)[C@H]4N[C@@H]5CC[C@H]4C5)C#N)ccc3c2c1 150617 US10238633, Example 291::US8987249, 291::US9713606, 291 Dipeptidyl peptidase 1 5.90 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150617&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937201 252824868 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500478 Fc1cc2c3ccc(cc3[nH]c(=O)c2cc1CC(NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)C#N 150618 US10238633, Example 292::US8987249, 292::US9713606, 292 Dipeptidyl peptidase 1 0.900 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150618 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150618&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937202 252824869 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500479 Fc1ccc2c(c1)[nH]c(=O)c1cc(CC(NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)c(F)cc21 150619 US10238633, Example 293::US8987249, 293::US9713606, 293 Dipeptidyl peptidase 1 1.30 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150619 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150619&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937203 252824870 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500480 Fc1cc2c3ccccc3[nH]c(=O)c2cc1CC(NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N 150620 US10238633, Example 294::US8987249, 294::US9713606, 294 Dipeptidyl peptidase 1 1.60 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150620&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937204 252824871 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500481 Fc1ccc2[nH]c(=O)c3cc(CC(NC(=O)[C@H]4N[C@@H]5CC[C@H]4C5)C#N)c(F)cc3c2c1 150621 US10238633, Example 295::US8987249, 295::US9713606, 295 Dipeptidyl peptidase 1 2.10 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150621&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937205 252824872 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500482 Fc1cc2c3ccc(CC(NC(=O)[C@H]4N[C@@H]5CC[C@H]4C5)C#N)cc3c(=O)[nH]c2c(F)c1F 150622 US10238633, Example 296::US8987249, 296::US9713606, 296 Dipeptidyl peptidase 1 2.90 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150622&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937206 252824873 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500483 Clc1ccc2c(c1)[nH]c(=O)c1cc(CC(NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)ccc21 150623 US10238633, Example 297::US8987249, 297::US9713606, 297 Dipeptidyl peptidase 1 3.20 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150623&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937207 252824874 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500484 O=C(NC(Cc1ccc2c3cc(ccc3[nH]c(=O)c2c1)C#N)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 150624 US10238633, Example 298::US8987249, 298::US9713606, 298 Dipeptidyl peptidase 1 3.20 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150624 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150624&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937208 252824875 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500485 COC(=O)c1ccc2[nH]c(=O)c3cc(CC(NC(=O)[C@H]4N[C@@H]5CC[C@H]4C5)C#N)ccc3c2c1 150625 US10238633, Example 299::US8987249, 299::US9713606, 299 Dipeptidyl peptidase 1 3.20 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150625&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937209 252824876 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500486 Fc1ccc2c3ccc(CC(NC(=O)[C@H]4N[C@@H]5CC[C@H]4C5)C#N)cc3c(=O)[nH]c2c1F 150626 US10238633, Example 300::US8987249, 300::US9713606, 300 Dipeptidyl peptidase 1 3.80 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150626&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937210 252824877 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500487 FC(F)(F)c1ccc2c(c1)[nH]c(=O)c1cc(C[C@H](NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)ccc21 150627 US10238633, Example 301::US8987249, 301::US9713606, 301 Dipeptidyl peptidase 1 4.50 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150627 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150627&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937211 252824878 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500488 FC(F)(F)c1cc2[nH]c(=O)c3cc(CC(NC(=O)[C@H]4N[C@@H]5CC[C@H]4C5)C#N)ccc3c2cc1C#N 150628 US10238633, Example 302::US8987249, 302::US9713606, 302 Dipeptidyl peptidase 1 4.70 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150628 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150628&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937212 252824879 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500489 Cn1c2cc(ccc2c2ccc(CC(NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)cc2c1=O)C#N InChI=1S/C25H23N5O2/c1-30-22-10-15(12-26)3-7-20(22)19-6-2-14(9-21(19)25(30)32)8-18(13-27)29-24(31)23-16-4-5-17(11-16)28-23/h2-3,6-7,9-10,16-18,23,28H,4-5,8,11H2,1H3,(H,29,31)/t16-,17+,18?,23-/m0/s1 JRJZXYNCCWJCKO-XDGMMDTHSA-N 150629 US10238633, Example 303::US8987249, 303::US9713606, 303 Dipeptidyl peptidase 1 5.00 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150629 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150629&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430280 252824880 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500490 Clc1ccc2[nH]c(=O)c3cc(CC(NC(=O)[C@H]4N[C@@H]5CC[C@H]4C5)C#N)ccc3c2c1 150630 US10238633, Example 304::US8987249, 304::US9713606, 304 Dipeptidyl peptidase 1 6.00 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150630 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150630&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937213 252824881 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500491 Cn1c2cc(Cl)ccc2c2ccc(CC(NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)cc2c1=O InChI=1S/C24H23ClN4O2/c1-29-21-11-15(25)4-7-19(21)18-6-2-13(9-20(18)24(29)31)8-17(12-26)28-23(30)22-14-3-5-16(10-14)27-22/h2,4,6-7,9,11,14,16-17,22,27H,3,5,8,10H2,1H3,(H,28,30)/t14-,16+,17?,22-/m0/s1 SVARUVQPDCVUTH-UHDBIXDDSA-N 150631 US10238633, Example 305::US8987249, 305::US9713606, 305 Dipeptidyl peptidase 1 6.90 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150631 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150631&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90415298 252824882 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51013603 CCn1cnc2c(Nc3cc(F)cc(F)c3)nc(nc12)C#N InChI=1S/C14H10F2N6/c1-2-22-7-18-12-13(20-11(6-17)21-14(12)22)19-10-4-8(15)3-9(16)5-10/h3-5,7H,2H2,1H3,(H,19,20,21) SZYYBVWPURUFRR-UHFFFAOYSA-N 50303420 6-(3,5-Difluorophenylamino)-9-ethyl-9H-purine-2-carbonitrile::6-[(3,5-difluorophenyl)amino]-9-ethyl-9H-purine-2-carbonitrile::CHEMBL567341 Dipeptidyl peptidase 1 34.67 ChEMBL 10.1021/jm901069a 10.7270/Q2TX3FG5 19908842 Mott, BT; Ferreira, RS; Simeonov, A; Jadhav, A; Ang, KK; Leister, W; Shen, M; Silveira, JT; Doyle, PS; Arkin, MR; McKerrow, JH; Inglese, J; Austin, CP; Thomas, CJ; Shoichet, BK; Maloney, DJ National Human Genome Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303420 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303420&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search QL2 3I06 44143088 104157781 CHEMBL567341 ZINC36379291 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51013604 FC(F)Cn1cnc2c(Nc3cc(F)cc(F)c3)nc(nc12)C#N InChI=1S/C14H8F4N6/c15-7-1-8(16)3-9(2-7)21-13-12-14(23-11(4-19)22-13)24(6-20-12)5-10(17)18/h1-3,6,10H,5H2,(H,21,22,23) VMJFQUMKCMNFSX-UHFFFAOYSA-N 50303436 9-(2,2-difluoroethyl)-6-(3,5-difluorophenylamino)-9H-purine-2-carbonitrile::CHEMBL578159 Dipeptidyl peptidase 1 6918.31 ChEMBL 10.1021/jm901069a 10.7270/Q2TX3FG5 19908842 Mott, BT; Ferreira, RS; Simeonov, A; Jadhav, A; Ang, KK; Leister, W; Shen, M; Silveira, JT; Doyle, PS; Arkin, MR; McKerrow, JH; Inglese, J; Austin, CP; Thomas, CJ; Shoichet, BK; Maloney, DJ National Human Genome Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303436 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303436&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 44143089 104157797 CHEMBL578159 ZINC36380047 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51013605 CCNc1nc(nc2n(cnc12)-c1cc(F)cc(F)c1)C#N InChI=1S/C14H10F2N6/c1-2-18-13-12-14(21-11(6-17)20-13)22(7-19-12)10-4-8(15)3-9(16)5-10/h3-5,7H,2H2,1H3,(H,18,20,21) VLZYXSQGILGQAI-UHFFFAOYSA-N 50303441 9-(3,5-Difluorophenyl)-6-(ethylamino)-9H-purine-2-carbonitrile::CHEMBL567134 Dipeptidyl peptidase 1 588.84 ChEMBL 10.1021/jm901069a 10.7270/Q2TX3FG5 19908842 Mott, BT; Ferreira, RS; Simeonov, A; Jadhav, A; Ang, KK; Leister, W; Shen, M; Silveira, JT; Doyle, PS; Arkin, MR; McKerrow, JH; Inglese, J; Austin, CP; Thomas, CJ; Shoichet, BK; Maloney, DJ National Human Genome Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303441&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 44143091 104157802 CHEMBL567134 ZINC36380036 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500493 Fc1cc(cc2c3ccc(CC(NC(=O)[C@H]4N[C@@H]5CC[C@H]4C5)C#N)cc3c(=O)[nH]c12)C#N 150633 US10238633, Example 307::US8987249, 307::US9713606, 307 Dipeptidyl peptidase 1 7.20 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150633 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150633&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937215 252824884 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500494 Fc1cccc2c3ccc(CC(NC(=O)[C@H]4N[C@@H]5CC[C@H]4C5)C#N)cc3c(=O)[nH]c12 150634 US10238633, Example 308::US8987249, 308::US9713606, 308 Dipeptidyl peptidase 1 8.30 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150634 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150634&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937216 252824885 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500495 O=C(NC(Cc1ccc2c3ccc(cc3[nH]c(=O)c2c1)C#N)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 150635 US10238633, Example 309::US8987249, 309::US9713606, 309 Dipeptidyl peptidase 1 9.10 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150635 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150635&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937217 252824886 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50521424 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)[C@@H]1CNCCCO1 InChI=1S/C22H22N4O2/c23-13-17-4-8-19(9-5-17)18-6-2-16(3-7-18)12-20(14-24)26-22(27)21-15-25-10-1-11-28-21/h2-9,20-21,25H,1,10-12,15H2,(H,26,27)/t20-,21-/m0/s1 FCRODBUNBQJNPU-SFTDATJTSA-N 50195236 CHEMBL3927609::US10287258, Example 1::US10669245, Example 1::US11117874, Example 1::US11673871, Example 34::US11680049, Example 1 Dipeptidyl peptidase 1 32 ChEMBL 10.1021/acs.jmedchem.6b01127 10.7270/Q2Z321K4 27690432 Connolly, S; Lönn, H; Käck, H; Van de Poël, A; Dahl, G; Doyle, K; Gardiner, P; Root, J; Wikell, C; Johannesson, P; Stenvall, K; Swallow, S CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195236&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253857 375977091 CHEMBL3927609 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50521425 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)[C@@H]1CCCNC1 InChI=1S/C22H22N4O/c23-13-17-5-9-19(10-6-17)18-7-3-16(4-8-18)12-21(14-24)26-22(27)20-2-1-11-25-15-20/h3-10,20-21,25H,1-2,11-12,15H2,(H,26,27)/t20-,21+/m1/s1 GAYFBSKWCFGDPJ-RTWAWAEBSA-N 50195237 CHEMBL3938314 Dipeptidyl peptidase 1 <10000 ChEMBL 10.1021/acs.jmedchem.6b01127 10.7270/Q2Z321K4 27690432 Connolly, S; Lönn, H; Käck, H; Van de Poël, A; Dahl, G; Doyle, K; Gardiner, P; Root, J; Wikell, C; Johannesson, P; Stenvall, K; Swallow, S CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195237 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195237&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 134148630 375977092 CHEMBL3938314 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50521426 CN1C(=O)COc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H26N4O4/c1-28-20-12-18(7-8-21(20)32-15-23(28)29)17-5-3-16(4-6-17)11-19(13-25)27-24(30)22-14-26-9-2-10-31-22/h3-8,12,19,22,26H,2,9-11,14-15H2,1H3,(H,27,30)/t19-,22-/m0/s1 QKDQSHLZLZUQOA-UGKGYDQZSA-N 50195238 CHEMBL3962926::US10287258, Example 20::US10669245, Example 20::US11117874, Example 20::US11655221, Example 20::US11680049, Example 20 Dipeptidyl peptidase 1 13 ChEMBL 10.1021/acs.jmedchem.6b01127 10.7270/Q2Z321K4 27690432 Connolly, S; Lönn, H; Käck, H; Van de Poël, A; Dahl, G; Doyle, K; Gardiner, P; Root, J; Wikell, C; Johannesson, P; Stenvall, K; Swallow, S CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195238 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195238&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253870 375977093 CHEMBL3962926 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50521427 Cn1c2cc(ccc2sc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H24N4O3S/c1-27-19-12-17(7-8-21(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)20-14-25-9-2-10-30-20/h3-8,12,18,20,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,20-/m0/s1 DRQDONWWFWYTII-ICSRJNTNSA-N 50195239 CHEMBL3972563::US10287258, Example 29::US10669245, Example 29::US11117874, Example 29::US11655221, Example 29::US11680049, Example 29 Dipeptidyl peptidase 1 3.2 ChEMBL 10.1021/acs.jmedchem.6b01127 10.7270/Q2Z321K4 27690432 Connolly, S; Lönn, H; Käck, H; Van de Poël, A; Dahl, G; Doyle, K; Gardiner, P; Root, J; Wikell, C; Johannesson, P; Stenvall, K; Swallow, S CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195239&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91826235 375977094 CHEMBL3972563 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50521429 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)[C@H]1CNCCO1 InChI=1S/C21H20N4O2/c22-12-16-3-7-18(8-4-16)17-5-1-15(2-6-17)11-19(13-23)25-21(26)20-14-24-9-10-27-20/h1-8,19-20,24H,9-11,14H2,(H,25,26)/t19-,20+/m0/s1 RRHRRYYDUYYNPP-VQTJNVASSA-N 50195241 CHEMBL3947105 Dipeptidyl peptidase 1 <10000 ChEMBL 10.1021/acs.jmedchem.6b01127 10.7270/Q2Z321K4 27690432 Connolly, S; Lönn, H; Käck, H; Van de Poël, A; Dahl, G; Doyle, K; Gardiner, P; Root, J; Wikell, C; Johannesson, P; Stenvall, K; Swallow, S CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195241 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195241&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 134147640 375977096 CHEMBL3947105 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50521431 CN1C(=O)C(F)(F)c2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H24F2N4O3/c1-30-20-12-17(7-8-19(20)24(25,26)23(30)32)16-5-3-15(4-6-16)11-18(13-27)29-22(31)21-14-28-9-2-10-33-21/h3-8,12,18,21,28H,2,9-11,14H2,1H3,(H,29,31)/t18-,21-/m0/s1 SABYNPLHFAPZQF-RXVVDRJESA-N 50195242 CHEMBL3917575::US10287258, Example 14::US10669245, Example 14::US11117874, Example 14::US11655221, Example 14::US11680049, Example 14 Dipeptidyl peptidase 1 16 ChEMBL 10.1021/acs.jmedchem.6b01127 10.7270/Q2Z321K4 27690432 Connolly, S; Lönn, H; Käck, H; Van de Poël, A; Dahl, G; Doyle, K; Gardiner, P; Root, J; Wikell, C; Johannesson, P; Stenvall, K; Swallow, S CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195242&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253811 375977097 CHEMBL3917575 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50521434 Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H24N4O4/c1-27-19-12-17(7-8-20(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)21-14-25-9-2-10-30-21/h3-8,12,18,21,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,21-/m0/s1 AEXFXNFMSAAELR-RXVVDRJESA-N 50195235 CHEMBL3900409::US10287258, Example 2::US10669245, Example 2::US11117874, Example 2::US11655221, Example 2::US11680049, Example 2 Dipeptidyl peptidase 1 115 ChEMBL 10.1021/acs.jmedchem.6b01127 10.7270/Q2Z321K4 27690432 Connolly, S; Lönn, H; Käck, H; Van de Poël, A; Dahl, G; Doyle, K; Gardiner, P; Root, J; Wikell, C; Johannesson, P; Stenvall, K; Swallow, S CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195235&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253852 375977090 CHEMBL3900409 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50521439 Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H24N4O4/c1-27-19-12-17(7-8-20(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)21-14-25-9-2-10-30-21/h3-8,12,18,21,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,21-/m0/s1 AEXFXNFMSAAELR-RXVVDRJESA-N 50195235 CHEMBL3900409::US10287258, Example 2::US10669245, Example 2::US11117874, Example 2::US11655221, Example 2::US11680049, Example 2 Dipeptidyl peptidase 1 141 ChEMBL 10.1021/acs.jmedchem.6b01127 10.7270/Q2Z321K4 27690432 Connolly, S; Lönn, H; Käck, H; Van de Poël, A; Dahl, G; Doyle, K; Gardiner, P; Root, J; Wikell, C; Johannesson, P; Stenvall, K; Swallow, S CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195235&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253852 375977090 CHEMBL3900409 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50521440 Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H24N4O4/c1-27-19-12-17(7-8-20(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)21-14-25-9-2-10-30-21/h3-8,12,18,21,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,21-/m0/s1 AEXFXNFMSAAELR-RXVVDRJESA-N 50195235 CHEMBL3900409::US10287258, Example 2::US10669245, Example 2::US11117874, Example 2::US11655221, Example 2::US11680049, Example 2 Dipeptidyl peptidase 1 209 ChEMBL 10.1021/acs.jmedchem.6b01127 10.7270/Q2Z321K4 27690432 Connolly, S; Lönn, H; Käck, H; Van de Poël, A; Dahl, G; Doyle, K; Gardiner, P; Root, J; Wikell, C; Johannesson, P; Stenvall, K; Swallow, S CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195235&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253852 375977090 CHEMBL3900409 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50521441 FC(F)(F)c1cnc(nc1)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C20H20F3N5O2/c21-20(22,23)15-10-26-18(27-11-15)14-4-2-13(3-5-14)8-16(9-24)28-19(29)17-12-25-6-1-7-30-17/h2-5,10-11,16-17,25H,1,6-8,12H2,(H,28,29)/t16-,17-/m0/s1 PQGYESNKRDSLIY-IRXDYDNUSA-N 50195243 CHEMBL3908639 Dipeptidyl peptidase 1 200 ChEMBL 10.1021/acs.jmedchem.6b01127 10.7270/Q2Z321K4 27690432 Connolly, S; Lönn, H; Käck, H; Van de Poël, A; Dahl, G; Doyle, K; Gardiner, P; Root, J; Wikell, C; Johannesson, P; Stenvall, K; Swallow, S CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195243 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195243&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 134131850 375977098 CHEMBL3908639 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50521442 Cn1c2cc(ccc2ccc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C25H26N4O3/c1-29-22-14-20(8-7-19(22)9-10-24(29)30)18-5-3-17(4-6-18)13-21(15-26)28-25(31)23-16-27-11-2-12-32-23/h3-10,14,21,23,27H,2,11-13,16H2,1H3,(H,28,31)/t21-,23-/m0/s1 BQIZWZAQEICNDG-GMAHTHKFSA-N 50195244 CHEMBL3926554::US10287258, Example 24::US10669245, Example 24::US11117874, Example 24::US11655221, Example 24::US11680049, Example 24 Dipeptidyl peptidase 1 13 ChEMBL 10.1021/acs.jmedchem.6b01127 10.7270/Q2Z321K4 27690432 Connolly, S; Lönn, H; Käck, H; Van de Poël, A; Dahl, G; Doyle, K; Gardiner, P; Root, J; Wikell, C; Johannesson, P; Stenvall, K; Swallow, S CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195244&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253851 375977099 CHEMBL3926554 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50521443 Cc1noc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H24N4O3/c1-15-20-12-18(7-8-21(20)30-27-15)17-5-3-16(4-6-17)11-19(13-24)26-23(28)22-14-25-9-2-10-29-22/h3-8,12,19,22,25H,2,9-11,14H2,1H3,(H,26,28)/t19-,22-/m0/s1 QCTYSVBOKIUUFU-UGKGYDQZSA-N 50195245 CHEMBL3972158::US10287258, Example 5::US10669245, Example 5::US11117874, Example 5::US11655221, Example 5::US11680049, Example 5 Dipeptidyl peptidase 1 16 ChEMBL 10.1021/acs.jmedchem.6b01127 10.7270/Q2Z321K4 27690432 Connolly, S; Lönn, H; Käck, H; Van de Poël, A; Dahl, G; Doyle, K; Gardiner, P; Root, J; Wikell, C; Johannesson, P; Stenvall, K; Swallow, S CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195245 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195245&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253855 375977100 CHEMBL3972158 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50521444 Cn1c2cc(ccc2sc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H24N4O3S/c1-27-19-12-17(7-8-21(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)20-14-25-9-2-10-30-20/h3-8,12,18,20,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,20-/m0/s1 DRQDONWWFWYTII-ICSRJNTNSA-N 50195239 CHEMBL3972563::US10287258, Example 29::US10669245, Example 29::US11117874, Example 29::US11655221, Example 29::US11680049, Example 29 Dipeptidyl peptidase 1 2.5 ChEMBL 10.1021/acs.jmedchem.6b01127 10.7270/Q2Z321K4 27690432 Connolly, S; Lönn, H; Käck, H; Van de Poël, A; Dahl, G; Doyle, K; Gardiner, P; Root, J; Wikell, C; Johannesson, P; Stenvall, K; Swallow, S CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195239&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91826235 375977094 CHEMBL3972563 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50521445 CCn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H26N4O4/c1-2-28-20-13-18(8-9-21(20)32-24(28)30)17-6-4-16(5-7-17)12-19(14-25)27-23(29)22-15-26-10-3-11-31-22/h4-9,13,19,22,26H,2-3,10-12,15H2,1H3,(H,27,29)/t19-,22-/m0/s1 HZZYFVOLMKQYKP-UGKGYDQZSA-N 50195246 CHEMBL3980602::US10287258, Example 16::US10669245, Example 16::US11117874, Example 16::US11655221, Example 16 Dipeptidyl peptidase 1 5.0 ChEMBL 10.1021/acs.jmedchem.6b01127 10.7270/Q2Z321K4 27690432 Connolly, S; Lönn, H; Käck, H; Van de Poël, A; Dahl, G; Doyle, K; Gardiner, P; Root, J; Wikell, C; Johannesson, P; Stenvall, K; Swallow, S CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195246 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195246&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253883 375977101 CHEMBL3980602 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50521446 CN1C(=O)Cc2ccc(cc12)-c1ccc(C[C@H](NC(=O)C2(N)CCOCC2)C#N)cc1 InChI=1S/C24H26N4O3/c1-28-21-13-18(6-7-19(21)14-22(28)29)17-4-2-16(3-5-17)12-20(15-25)27-23(30)24(26)8-10-31-11-9-24/h2-7,13,20H,8-12,14,26H2,1H3,(H,27,30)/t20-/m0/s1 LXJCXKAFPLOBTM-FQEVSTJZSA-N 50195247 CHEMBL3936580 Dipeptidyl peptidase 1 1.6 ChEMBL 10.1021/acs.jmedchem.6b01127 10.7270/Q2Z321K4 27690432 Connolly, S; Lönn, H; Käck, H; Van de Poël, A; Dahl, G; Doyle, K; Gardiner, P; Root, J; Wikell, C; Johannesson, P; Stenvall, K; Swallow, S CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195247 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195247&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 49783830 375977102 CHEMBL3936580 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50521447 FC(F)(F)c1cnc(nc1)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C20H20F3N5O2/c21-20(22,23)15-10-26-18(27-11-15)14-4-2-13(3-5-14)8-16(9-24)28-19(29)17-12-25-6-1-7-30-17/h2-5,10-11,16-17,25H,1,6-8,12H2,(H,28,29)/t16-,17-/m0/s1 PQGYESNKRDSLIY-IRXDYDNUSA-N 50195243 CHEMBL3908639 Dipeptidyl peptidase 1 200 ChEMBL 10.1021/acs.jmedchem.6b01127 10.7270/Q2Z321K4 27690432 Connolly, S; Lönn, H; Käck, H; Van de Poël, A; Dahl, G; Doyle, K; Gardiner, P; Root, J; Wikell, C; Johannesson, P; Stenvall, K; Swallow, S CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195243 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195243&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 134131850 375977098 CHEMBL3908639 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50521448 Cn1c2cc(ccc2ccc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C25H26N4O3/c1-29-22-14-20(8-7-19(22)9-10-24(29)30)18-5-3-17(4-6-18)13-21(15-26)28-25(31)23-16-27-11-2-12-32-23/h3-10,14,21,23,27H,2,11-13,16H2,1H3,(H,28,31)/t21-,23-/m0/s1 BQIZWZAQEICNDG-GMAHTHKFSA-N 50195244 CHEMBL3926554::US10287258, Example 24::US10669245, Example 24::US11117874, Example 24::US11655221, Example 24::US11680049, Example 24 Dipeptidyl peptidase 1 13 ChEMBL 10.1021/acs.jmedchem.6b01127 10.7270/Q2Z321K4 27690432 Connolly, S; Lönn, H; Käck, H; Van de Poël, A; Dahl, G; Doyle, K; Gardiner, P; Root, J; Wikell, C; Johannesson, P; Stenvall, K; Swallow, S CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195244&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253851 375977099 CHEMBL3926554 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50521449 Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H24N4O4/c1-27-19-12-17(7-8-20(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)21-14-25-9-2-10-30-21/h3-8,12,18,21,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,21-/m0/s1 AEXFXNFMSAAELR-RXVVDRJESA-N 50195235 CHEMBL3900409::US10287258, Example 2::US10669245, Example 2::US11117874, Example 2::US11655221, Example 2::US11680049, Example 2 Dipeptidyl peptidase 1 4.0 ChEMBL 10.1021/acs.jmedchem.6b01127 10.7270/Q2Z321K4 27690432 Connolly, S; Lönn, H; Käck, H; Van de Poël, A; Dahl, G; Doyle, K; Gardiner, P; Root, J; Wikell, C; Johannesson, P; Stenvall, K; Swallow, S CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195235&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253852 375977090 CHEMBL3900409 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50521450 FC(F)Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H24F2N4O4/c25-22(26)14-30-19-11-17(6-7-20(19)34-24(30)32)16-4-2-15(3-5-16)10-18(12-27)29-23(31)21-13-28-8-1-9-33-21/h2-7,11,18,21-22,28H,1,8-10,13-14H2,(H,29,31)/t18-,21-/m0/s1 ANPJTTUBCRFBKA-RXVVDRJESA-N 50195248 CHEMBL3891374::US10287258, Example 27::US10669245, Example 27::US11117874, Example 27::US11655221, Example 27::US11680049, Example 27 Dipeptidyl peptidase 1 6.3 ChEMBL 10.1021/acs.jmedchem.6b01127 10.7270/Q2Z321K4 27690432 Connolly, S; Lönn, H; Käck, H; Van de Poël, A; Dahl, G; Doyle, K; Gardiner, P; Root, J; Wikell, C; Johannesson, P; Stenvall, K; Swallow, S CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195248 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195248&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253888 375977103 CHEMBL3891374 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50521451 N[C@H]1CCCCC[C@H]1C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N InChI=1S/C24H26N4O/c25-15-18-8-12-20(13-9-18)19-10-6-17(7-11-19)14-21(16-26)28-24(29)22-4-2-1-3-5-23(22)27/h6-13,21-23H,1-5,14,27H2,(H,28,29)/t21-,22+,23-/m0/s1 ODOOVCKVACGPMD-ZRBLBEILSA-N 50195249 CHEMBL3970692 Dipeptidyl peptidase 1 32 ChEMBL 10.1021/acs.jmedchem.6b01127 10.7270/Q2Z321K4 27690432 Connolly, S; Lönn, H; Käck, H; Van de Poël, A; Dahl, G; Doyle, K; Gardiner, P; Root, J; Wikell, C; Johannesson, P; Stenvall, K; Swallow, S CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195249 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195249&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 134154191 375977104 CHEMBL3970692 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50521452 N[C@H]1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N InChI=1S/C22H22N4O/c23-13-16-6-10-18(11-7-16)17-8-4-15(5-9-17)12-19(14-24)26-22(27)20-2-1-3-21(20)25/h4-11,19-21H,1-3,12,25H2,(H,26,27)/t19-,20+,21-/m0/s1 BYOFYTPXWXWPLL-HBMCJLEFSA-N 50195250 CHEMBL3906771 Dipeptidyl peptidase 1 1259 ChEMBL 10.1021/acs.jmedchem.6b01127 10.7270/Q2Z321K4 27690432 Connolly, S; Lönn, H; Käck, H; Van de Poël, A; Dahl, G; Doyle, K; Gardiner, P; Root, J; Wikell, C; Johannesson, P; Stenvall, K; Swallow, S CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195250 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195250&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 134134976 375977105 CHEMBL3906771 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50521453 N[C@H]1CCCC[C@H]1C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N InChI=1S/C23H24N4O/c24-14-17-7-11-19(12-8-17)18-9-5-16(6-10-18)13-20(15-25)27-23(28)21-3-1-2-4-22(21)26/h5-12,20-22H,1-4,13,26H2,(H,27,28)/t20-,21+,22-/m0/s1 QTAPOAIUZAWSEL-BDTNDASRSA-N 50195251 CHEMBL3927522 Dipeptidyl peptidase 1 40 ChEMBL 10.1021/acs.jmedchem.6b01127 10.7270/Q2Z321K4 27690432 Connolly, S; Lönn, H; Käck, H; Van de Poël, A; Dahl, G; Doyle, K; Gardiner, P; Root, J; Wikell, C; Johannesson, P; Stenvall, K; Swallow, S CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195251 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195251&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 134141023 375977106 CHEMBL3927522 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50521454 NC1(CCOCC1)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N InChI=1S/C22H22N4O2/c23-14-17-3-7-19(8-4-17)18-5-1-16(2-6-18)13-20(15-24)26-21(27)22(25)9-11-28-12-10-22/h1-8,20H,9-13,25H2,(H,26,27)/t20-/m0/s1 NNUFRZJZOXVZIT-FQEVSTJZSA-N 50011502 CHEMBL3261926 Dipeptidyl peptidase 1 7.9 ChEMBL 10.1021/acs.jmedchem.6b01127 10.7270/Q2Z321K4 27690432 Connolly, S; Lönn, H; Käck, H; Van de Poël, A; Dahl, G; Doyle, K; Gardiner, P; Root, J; Wikell, C; Johannesson, P; Stenvall, K; Swallow, S CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50011502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50011502&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 49783666 103924055 CHEMBL3261926 ZINC36271864 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50521455 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)[C@@H]1CNCCCO1 InChI=1S/C22H22N4O2/c23-13-17-4-8-19(9-5-17)18-6-2-16(3-7-18)12-20(14-24)26-22(27)21-15-25-10-1-11-28-21/h2-9,20-21,25H,1,10-12,15H2,(H,26,27)/t20-,21-/m0/s1 FCRODBUNBQJNPU-SFTDATJTSA-N 50195236 CHEMBL3927609::US10287258, Example 1::US10669245, Example 1::US11117874, Example 1::US11673871, Example 34::US11680049, Example 1 Dipeptidyl peptidase 1 40 ChEMBL 10.1021/acs.jmedchem.6b01127 10.7270/Q2Z321K4 27690432 Connolly, S; Lönn, H; Käck, H; Van de Poël, A; Dahl, G; Doyle, K; Gardiner, P; Root, J; Wikell, C; Johannesson, P; Stenvall, K; Swallow, S CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195236&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253857 375977091 CHEMBL3927609 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50521456 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)C1CCCCNC1 InChI=1S/C23H24N4O/c24-14-18-6-10-20(11-7-18)19-8-4-17(5-9-19)13-22(15-25)27-23(28)21-3-1-2-12-26-16-21/h4-11,21-22,26H,1-3,12-13,16H2,(H,27,28)/t21?,22-/m0/s1 ZSKRFSFJXYNREY-KEKNWZKVSA-N 50195252 CHEMBL3937199 Dipeptidyl peptidase 1 1259 ChEMBL 10.1021/acs.jmedchem.6b01127 10.7270/Q2Z321K4 27690432 Connolly, S; Lönn, H; Käck, H; Van de Poël, A; Dahl, G; Doyle, K; Gardiner, P; Root, J; Wikell, C; Johannesson, P; Stenvall, K; Swallow, S CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195252 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195252&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 134148503 375977107 CHEMBL3937199 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50521457 N[C@@H]1CCCC[C@H]1C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N InChI=1S/C23H24N4O/c24-14-17-7-11-19(12-8-17)18-9-5-16(6-10-18)13-20(15-25)27-23(28)21-3-1-2-4-22(21)26/h5-12,20-22H,1-4,13,26H2,(H,27,28)/t20-,21+,22+/m0/s1 QTAPOAIUZAWSEL-BHDDXSALSA-N 50195253 CHEMBL3929272 Dipeptidyl peptidase 1 316 ChEMBL 10.1021/acs.jmedchem.6b01127 10.7270/Q2Z321K4 27690432 Connolly, S; Lönn, H; Käck, H; Van de Poël, A; Dahl, G; Doyle, K; Gardiner, P; Root, J; Wikell, C; Johannesson, P; Stenvall, K; Swallow, S CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195253 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195253&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 134138927 375977108 CHEMBL3929272 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50521458 N[C@@H]1CCCC[C@@H]1C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N InChI=1S/C23H24N4O/c24-14-17-7-11-19(12-8-17)18-9-5-16(6-10-18)13-20(15-25)27-23(28)21-3-1-2-4-22(21)26/h5-12,20-22H,1-4,13,26H2,(H,27,28)/t20-,21-,22+/m0/s1 QTAPOAIUZAWSEL-FDFHNCONSA-N 50195254 CHEMBL3901320 Dipeptidyl peptidase 1 <10000 ChEMBL 10.1021/acs.jmedchem.6b01127 10.7270/Q2Z321K4 27690432 Connolly, S; Lönn, H; Käck, H; Van de Poël, A; Dahl, G; Doyle, K; Gardiner, P; Root, J; Wikell, C; Johannesson, P; Stenvall, K; Swallow, S CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195254 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195254&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 134134303 375977109 CHEMBL3901320 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50521459 N[C@H]1CCCC[C@H]1C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N InChI=1S/C23H24N4O/c24-14-17-7-11-19(12-8-17)18-9-5-16(6-10-18)13-20(15-25)27-23(28)21-3-1-2-4-22(21)26/h5-12,20-22H,1-4,13,26H2,(H,27,28)/t20-,21+,22-/m0/s1 QTAPOAIUZAWSEL-BDTNDASRSA-N 50195251 CHEMBL3927522 Dipeptidyl peptidase 1 40 ChEMBL 10.1021/acs.jmedchem.6b01127 10.7270/Q2Z321K4 27690432 Connolly, S; Lönn, H; Käck, H; Van de Poël, A; Dahl, G; Doyle, K; Gardiner, P; Root, J; Wikell, C; Johannesson, P; Stenvall, K; Swallow, S CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195251 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195251&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 134141023 375977106 CHEMBL3927522 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50521460 NC1(CCOCC1)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N InChI=1S/C22H22N4O2/c23-14-17-3-7-19(8-4-17)18-5-1-16(2-6-18)13-20(15-24)26-21(27)22(25)9-11-28-12-10-22/h1-8,20H,9-13,25H2,(H,26,27)/t20-/m0/s1 NNUFRZJZOXVZIT-FQEVSTJZSA-N 50011502 CHEMBL3261926 Dipeptidyl peptidase 1 0.794328 ChEMBL 10.1021/acs.jmedchem.6b01127 10.7270/Q2Z321K4 27690432 Connolly, S; Lönn, H; Käck, H; Van de Poël, A; Dahl, G; Doyle, K; Gardiner, P; Root, J; Wikell, C; Johannesson, P; Stenvall, K; Swallow, S CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50011502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50011502&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 49783666 103924055 CHEMBL3261926 ZINC36271864 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50521465 FC(F)(F)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C22H22F3N3O2/c23-22(24,25)18-8-6-17(7-9-18)16-4-2-15(3-5-16)12-19(13-26)28-21(29)20-14-27-10-1-11-30-20/h2-9,19-20,27H,1,10-12,14H2,(H,28,29)/t19-,20-/m0/s1 USBDHHJQNTYSNJ-PMACEKPBSA-N 50195255 CHEMBL3945475::US10287258, Example 6::US10669245, Example 6::US11117874, Example 6::US11655221, Example 6::US11680049, Example 6 Dipeptidyl peptidase 1 40 ChEMBL 10.1021/acs.jmedchem.6b01127 10.7270/Q2Z321K4 27690432 Connolly, S; Lönn, H; Käck, H; Van de Poël, A; Dahl, G; Doyle, K; Gardiner, P; Root, J; Wikell, C; Johannesson, P; Stenvall, K; Swallow, S CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195255 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195255&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253859 375977110 CHEMBL3945475 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50521466 CCn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H26N4O4/c1-2-28-20-13-18(8-9-21(20)32-24(28)30)17-6-4-16(5-7-17)12-19(14-25)27-23(29)22-15-26-10-3-11-31-22/h4-9,13,19,22,26H,2-3,10-12,15H2,1H3,(H,27,29)/t19-,22-/m0/s1 HZZYFVOLMKQYKP-UGKGYDQZSA-N 50195246 CHEMBL3980602::US10287258, Example 16::US10669245, Example 16::US11117874, Example 16::US11655221, Example 16 Dipeptidyl peptidase 1 5.0 ChEMBL 10.1021/acs.jmedchem.6b01127 10.7270/Q2Z321K4 27690432 Connolly, S; Lönn, H; Käck, H; Van de Poël, A; Dahl, G; Doyle, K; Gardiner, P; Root, J; Wikell, C; Johannesson, P; Stenvall, K; Swallow, S CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195246 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195246&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253883 375977101 CHEMBL3980602 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50521467 Cn1c2cc(ccc2ncc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H25N5O3/c1-29-21-12-18(7-8-20(21)27-15-23(29)30)17-5-3-16(4-6-17)11-19(13-25)28-24(31)22-14-26-9-2-10-32-22/h3-8,12,15,19,22,26H,2,9-11,14H2,1H3,(H,28,31)/t19-,22-/m0/s1 WSJNXHOQZXVRSW-UGKGYDQZSA-N 50195256 CHEMBL3954197 Dipeptidyl peptidase 1 25 ChEMBL 10.1021/acs.jmedchem.6b01127 10.7270/Q2Z321K4 27690432 Connolly, S; Lönn, H; Käck, H; Van de Poël, A; Dahl, G; Doyle, K; Gardiner, P; Root, J; Wikell, C; Johannesson, P; Stenvall, K; Swallow, S CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195256 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195256&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 134145021 375977111 CHEMBL3954197 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50521468 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)[C@@H]1CNCCO1 InChI=1S/C21H20N4O2/c22-12-16-3-7-18(8-4-16)17-5-1-15(2-6-17)11-19(13-23)25-21(26)20-14-24-9-10-27-20/h1-8,19-20,24H,9-11,14H2,(H,25,26)/t19-,20-/m0/s1 RRHRRYYDUYYNPP-PMACEKPBSA-N 50195257 CHEMBL3919313 Dipeptidyl peptidase 1 398 ChEMBL 10.1021/acs.jmedchem.6b01127 10.7270/Q2Z321K4 27690432 Connolly, S; Lönn, H; Käck, H; Van de Poël, A; Dahl, G; Doyle, K; Gardiner, P; Root, J; Wikell, C; Johannesson, P; Stenvall, K; Swallow, S CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195257 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195257&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 134140481 375977112 CHEMBL3919313 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50521469 N[C@H]1CCCC[C@@H]1C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N InChI=1S/C23H24N4O/c24-14-17-7-11-19(12-8-17)18-9-5-16(6-10-18)13-20(15-25)27-23(28)21-3-1-2-4-22(21)26/h5-12,20-22H,1-4,13,26H2,(H,27,28)/t20-,21-,22-/m0/s1 QTAPOAIUZAWSEL-FKBYEOEOSA-N 50195258 CHEMBL3899487 Dipeptidyl peptidase 1 398 ChEMBL 10.1021/acs.jmedchem.6b01127 10.7270/Q2Z321K4 27690432 Connolly, S; Lönn, H; Käck, H; Van de Poël, A; Dahl, G; Doyle, K; Gardiner, P; Root, J; Wikell, C; Johannesson, P; Stenvall, K; Swallow, S CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195258 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195258&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 134134180 375977113 CHEMBL3899487 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50521470 Cc1cc(cc2n(C)c(=O)oc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H26N4O4/c1-15-10-18(12-20-22(15)32-24(30)28(20)2)17-6-4-16(5-7-17)11-19(13-25)27-23(29)21-14-26-8-3-9-31-21/h4-7,10,12,19,21,26H,3,8-9,11,14H2,1-2H3,(H,27,29)/t19-,21-/m0/s1 WCWJGAFMGPMBQG-FPOVZHCZSA-N 50195240 CHEMBL3960432::US10287258, Example 3::US10669245, Example 3::US11117874, Example 3::US11655221, Example 3::US11680049, Example 3 Dipeptidyl peptidase 1 10.0 ChEMBL 10.1021/acs.jmedchem.6b01127 10.7270/Q2Z321K4 27690432 Connolly, S; Lönn, H; Käck, H; Van de Poël, A; Dahl, G; Doyle, K; Gardiner, P; Root, J; Wikell, C; Johannesson, P; Stenvall, K; Swallow, S CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195240&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253824 375977095 CHEMBL3960432 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50521475 Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H24N4O4/c1-27-19-12-17(7-8-20(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)21-14-25-9-2-10-30-21/h3-8,12,18,21,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,21-/m0/s1 AEXFXNFMSAAELR-RXVVDRJESA-N 50195235 CHEMBL3900409::US10287258, Example 2::US10669245, Example 2::US11117874, Example 2::US11655221, Example 2::US11680049, Example 2 Dipeptidyl peptidase 1 62 ChEMBL 10.1021/acs.jmedchem.6b01127 10.7270/Q2Z321K4 27690432 Connolly, S; Lönn, H; Käck, H; Van de Poël, A; Dahl, G; Doyle, K; Gardiner, P; Root, J; Wikell, C; Johannesson, P; Stenvall, K; Swallow, S CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195235&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253852 375977090 CHEMBL3900409 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50521476 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)[C@@H]1CNCCO1 InChI=1S/C21H20N4O2/c22-12-16-3-7-18(8-4-16)17-5-1-15(2-6-17)11-19(13-23)25-21(26)20-14-24-9-10-27-20/h1-8,19-20,24H,9-11,14H2,(H,25,26)/t19-,20-/m0/s1 RRHRRYYDUYYNPP-PMACEKPBSA-N 50195257 CHEMBL3919313 Dipeptidyl peptidase 1 501 ChEMBL 10.1021/acs.jmedchem.6b01127 10.7270/Q2Z321K4 27690432 Connolly, S; Lönn, H; Käck, H; Van de Poël, A; Dahl, G; Doyle, K; Gardiner, P; Root, J; Wikell, C; Johannesson, P; Stenvall, K; Swallow, S CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195257 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195257&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 134140481 375977112 CHEMBL3919313 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50521477 N[C@@H]1CCCC[C@H]1C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N InChI=1S/C23H24N4O/c24-14-17-7-11-19(12-8-17)18-9-5-16(6-10-18)13-20(15-25)27-23(28)21-3-1-2-4-22(21)26/h5-12,20-22H,1-4,13,26H2,(H,27,28)/t20-,21+,22+/m0/s1 QTAPOAIUZAWSEL-BHDDXSALSA-N 50195253 CHEMBL3929272 Dipeptidyl peptidase 1 158 ChEMBL 10.1021/acs.jmedchem.6b01127 10.7270/Q2Z321K4 27690432 Connolly, S; Lönn, H; Käck, H; Van de Poël, A; Dahl, G; Doyle, K; Gardiner, P; Root, J; Wikell, C; Johannesson, P; Stenvall, K; Swallow, S CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195253 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195253&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 134138927 375977108 CHEMBL3929272 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50521478 NC1CCCCC1C(=O)N[C@@H](Cc1ccc(cc1)-c1cccc(c1)C#N)C#N InChI=1S/C23H24N4O/c24-14-17-4-3-5-19(12-17)18-10-8-16(9-11-18)13-20(15-25)27-23(28)21-6-1-2-7-22(21)26/h3-5,8-12,20-22H,1-2,6-7,13,26H2,(H,27,28)/t20-,21?,22?/m0/s1 SXZPZXJTWPGYTE-HWELCPFYSA-N 50195259 CHEMBL3898680 Dipeptidyl peptidase 1 1000 ChEMBL 10.1021/acs.jmedchem.6b01127 10.7270/Q2Z321K4 27690432 Connolly, S; Lönn, H; Käck, H; Van de Poël, A; Dahl, G; Doyle, K; Gardiner, P; Root, J; Wikell, C; Johannesson, P; Stenvall, K; Swallow, S CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195259 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195259&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 134134473 375977114 CHEMBL3898680 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50521479 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)[C@H]1CCCNC1 InChI=1S/C22H22N4O/c23-13-17-5-9-19(10-6-17)18-7-3-16(4-8-18)12-21(14-24)26-22(27)20-2-1-11-25-15-20/h3-10,20-21,25H,1-2,11-12,15H2,(H,26,27)/t20-,21-/m0/s1 GAYFBSKWCFGDPJ-SFTDATJTSA-N 50195260 CHEMBL3910381 Dipeptidyl peptidase 1 <10000 ChEMBL 10.1021/acs.jmedchem.6b01127 10.7270/Q2Z321K4 27690432 Connolly, S; Lönn, H; Käck, H; Van de Poël, A; Dahl, G; Doyle, K; Gardiner, P; Root, J; Wikell, C; Johannesson, P; Stenvall, K; Swallow, S CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195260 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195260&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 134132070 375977115 CHEMBL3910381 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50521480 N[C@H]1CCCCC[C@H]1C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N InChI=1S/C24H26N4O/c25-15-18-8-12-20(13-9-18)19-10-6-17(7-11-19)14-21(16-26)28-24(29)22-4-2-1-3-5-23(22)27/h6-13,21-23H,1-5,14,27H2,(H,28,29)/t21-,22+,23-/m0/s1 ODOOVCKVACGPMD-ZRBLBEILSA-N 50195249 CHEMBL3970692 Dipeptidyl peptidase 1 40 ChEMBL 10.1021/acs.jmedchem.6b01127 10.7270/Q2Z321K4 27690432 Connolly, S; Lönn, H; Käck, H; Van de Poël, A; Dahl, G; Doyle, K; Gardiner, P; Root, J; Wikell, C; Johannesson, P; Stenvall, K; Swallow, S CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195249 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195249&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 134154191 375977104 CHEMBL3970692 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50521481 N[C@H]1CCCC[C@@H]1C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N InChI=1S/C23H24N4O/c24-14-17-7-11-19(12-8-17)18-9-5-16(6-10-18)13-20(15-25)27-23(28)21-3-1-2-4-22(21)26/h5-12,20-22H,1-4,13,26H2,(H,27,28)/t20-,21-,22-/m0/s1 QTAPOAIUZAWSEL-FKBYEOEOSA-N 50195258 CHEMBL3899487 Dipeptidyl peptidase 1 501 ChEMBL 10.1021/acs.jmedchem.6b01127 10.7270/Q2Z321K4 27690432 Connolly, S; Lönn, H; Käck, H; Van de Poël, A; Dahl, G; Doyle, K; Gardiner, P; Root, J; Wikell, C; Johannesson, P; Stenvall, K; Swallow, S CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195258 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195258&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 134134180 375977113 CHEMBL3899487 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50521482 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)C1CCCCNC1 InChI=1S/C23H24N4O/c24-14-18-6-10-20(11-7-18)19-8-4-17(5-9-19)13-22(15-25)27-23(28)21-3-1-2-12-26-16-21/h4-11,21-22,26H,1-3,12-13,16H2,(H,27,28)/t21?,22-/m0/s1 ZSKRFSFJXYNREY-KEKNWZKVSA-N 50195252 CHEMBL3937199 Dipeptidyl peptidase 1 501 ChEMBL 10.1021/acs.jmedchem.6b01127 10.7270/Q2Z321K4 27690432 Connolly, S; Lönn, H; Käck, H; Van de Poël, A; Dahl, G; Doyle, K; Gardiner, P; Root, J; Wikell, C; Johannesson, P; Stenvall, K; Swallow, S CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195252 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195252&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 134148503 375977107 CHEMBL3937199 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50521483 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)[C@H]1CNCCCO1 InChI=1S/C22H22N4O2/c23-13-17-4-8-19(9-5-17)18-6-2-16(3-7-18)12-20(14-24)26-22(27)21-15-25-10-1-11-28-21/h2-9,20-21,25H,1,10-12,15H2,(H,26,27)/t20-,21+/m0/s1 FCRODBUNBQJNPU-LEWJYISDSA-N 50195261 CHEMBL3899584 Dipeptidyl peptidase 1 6310 ChEMBL 10.1021/acs.jmedchem.6b01127 10.7270/Q2Z321K4 27690432 Connolly, S; Lönn, H; Käck, H; Van de Poël, A; Dahl, G; Doyle, K; Gardiner, P; Root, J; Wikell, C; Johannesson, P; Stenvall, K; Swallow, S CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195261 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195261&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253818 375977116 CHEMBL3899584 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50521484 N[C@H]1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N InChI=1S/C22H22N4O/c23-13-16-6-10-18(11-7-16)17-8-4-15(5-9-17)12-19(14-24)26-22(27)20-2-1-3-21(20)25/h4-11,19-21H,1-3,12,25H2,(H,26,27)/t19-,20+,21-/m0/s1 BYOFYTPXWXWPLL-HBMCJLEFSA-N 50195250 CHEMBL3906771 Dipeptidyl peptidase 1 1000 ChEMBL 10.1021/acs.jmedchem.6b01127 10.7270/Q2Z321K4 27690432 Connolly, S; Lönn, H; Käck, H; Van de Poël, A; Dahl, G; Doyle, K; Gardiner, P; Root, J; Wikell, C; Johannesson, P; Stenvall, K; Swallow, S CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195250 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195250&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 134134976 375977105 CHEMBL3906771 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50521486 CN1C(=O)C(F)(F)c2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H24F2N4O3/c1-30-20-12-17(7-8-19(20)24(25,26)23(30)32)16-5-3-15(4-6-16)11-18(13-27)29-22(31)21-14-28-9-2-10-33-21/h3-8,12,18,21,28H,2,9-11,14H2,1H3,(H,29,31)/t18-,21-/m0/s1 SABYNPLHFAPZQF-RXVVDRJESA-N 50195242 CHEMBL3917575::US10287258, Example 14::US10669245, Example 14::US11117874, Example 14::US11655221, Example 14::US11680049, Example 14 Dipeptidyl peptidase 1 16 ChEMBL 10.1021/acs.jmedchem.6b01127 10.7270/Q2Z321K4 27690432 Connolly, S; Lönn, H; Käck, H; Van de Poël, A; Dahl, G; Doyle, K; Gardiner, P; Root, J; Wikell, C; Johannesson, P; Stenvall, K; Swallow, S CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195242&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253811 375977097 CHEMBL3917575 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50521487 Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H24N4O4/c1-27-19-12-17(7-8-20(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)21-14-25-9-2-10-30-21/h3-8,12,18,21,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,21-/m0/s1 AEXFXNFMSAAELR-RXVVDRJESA-N 50195235 CHEMBL3900409::US10287258, Example 2::US10669245, Example 2::US11117874, Example 2::US11655221, Example 2::US11680049, Example 2 Dipeptidyl peptidase 1 4.0 ChEMBL 10.1021/acs.jmedchem.6b01127 10.7270/Q2Z321K4 27690432 Connolly, S; Lönn, H; Käck, H; Van de Poël, A; Dahl, G; Doyle, K; Gardiner, P; Root, J; Wikell, C; Johannesson, P; Stenvall, K; Swallow, S CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195235&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253852 375977090 CHEMBL3900409 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50521488 CN1C(=O)COc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H26N4O4/c1-28-20-12-18(7-8-21(20)32-15-23(28)29)17-5-3-16(4-6-17)11-19(13-25)27-24(30)22-14-26-9-2-10-31-22/h3-8,12,19,22,26H,2,9-11,14-15H2,1H3,(H,27,30)/t19-,22-/m0/s1 QKDQSHLZLZUQOA-UGKGYDQZSA-N 50195238 CHEMBL3962926::US10287258, Example 20::US10669245, Example 20::US11117874, Example 20::US11655221, Example 20::US11680049, Example 20 Dipeptidyl peptidase 1 13 ChEMBL 10.1021/acs.jmedchem.6b01127 10.7270/Q2Z321K4 27690432 Connolly, S; Lönn, H; Käck, H; Van de Poël, A; Dahl, G; Doyle, K; Gardiner, P; Root, J; Wikell, C; Johannesson, P; Stenvall, K; Swallow, S CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195238 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195238&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253870 375977093 CHEMBL3962926 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50521489 Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H24N4O4/c1-27-19-12-17(7-8-20(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)21-14-25-9-2-10-30-21/h3-8,12,18,21,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,21-/m0/s1 AEXFXNFMSAAELR-RXVVDRJESA-N 50195235 CHEMBL3900409::US10287258, Example 2::US10669245, Example 2::US11117874, Example 2::US11655221, Example 2::US11680049, Example 2 Dipeptidyl peptidase 1 2.5 ChEMBL 10.1021/acs.jmedchem.6b01127 10.7270/Q2Z321K4 27690432 Connolly, S; Lönn, H; Käck, H; Van de Poël, A; Dahl, G; Doyle, K; Gardiner, P; Root, J; Wikell, C; Johannesson, P; Stenvall, K; Swallow, S CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195235&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253852 375977090 CHEMBL3900409 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50521490 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)C1CNCCCO1 InChI=1S/C22H22N4O2/c23-13-17-4-8-19(9-5-17)18-6-2-16(3-7-18)12-20(14-24)26-22(27)21-15-25-10-1-11-28-21/h2-9,20-21,25H,1,10-12,15H2,(H,26,27)/t20-,21?/m0/s1 FCRODBUNBQJNPU-BGERDNNASA-N 50195262 CHEMBL3966946::US11655221, Example 34 Dipeptidyl peptidase 1 63 ChEMBL 10.1021/acs.jmedchem.6b01127 10.7270/Q2Z321K4 27690432 Connolly, S; Lönn, H; Käck, H; Van de Poël, A; Dahl, G; Doyle, K; Gardiner, P; Root, J; Wikell, C; Johannesson, P; Stenvall, K; Swallow, S CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195262 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195262&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118260121 375977117 CHEMBL3966946 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50521491 CN1C(=O)Cc2ccc(cc12)-c1ccc(C[C@H](NC(=O)C2(N)CCOCC2)C#N)cc1 InChI=1S/C24H26N4O3/c1-28-21-13-18(6-7-19(21)14-22(28)29)17-4-2-16(3-5-17)12-20(15-25)27-23(30)24(26)8-10-31-11-9-24/h2-7,13,20H,8-12,14,26H2,1H3,(H,27,30)/t20-/m0/s1 LXJCXKAFPLOBTM-FQEVSTJZSA-N 50195247 CHEMBL3936580 Dipeptidyl peptidase 1 0.251189 ChEMBL 10.1021/acs.jmedchem.6b01127 10.7270/Q2Z321K4 27690432 Connolly, S; Lönn, H; Käck, H; Van de Poël, A; Dahl, G; Doyle, K; Gardiner, P; Root, J; Wikell, C; Johannesson, P; Stenvall, K; Swallow, S CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195247 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195247&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 49783830 375977102 CHEMBL3936580 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50521494 Cc1noc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H24N4O3/c1-15-20-12-18(7-8-21(20)30-27-15)17-5-3-16(4-6-17)11-19(13-24)26-23(28)22-14-25-9-2-10-29-22/h3-8,12,19,22,25H,2,9-11,14H2,1H3,(H,26,28)/t19-,22-/m0/s1 QCTYSVBOKIUUFU-UGKGYDQZSA-N 50195245 CHEMBL3972158::US10287258, Example 5::US10669245, Example 5::US11117874, Example 5::US11655221, Example 5::US11680049, Example 5 Dipeptidyl peptidase 1 16 ChEMBL 10.1021/acs.jmedchem.6b01127 10.7270/Q2Z321K4 27690432 Connolly, S; Lönn, H; Käck, H; Van de Poël, A; Dahl, G; Doyle, K; Gardiner, P; Root, J; Wikell, C; Johannesson, P; Stenvall, K; Swallow, S CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195245 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195245&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253855 375977100 CHEMBL3972158 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50521495 Cc1cc(cc2n(C)c(=O)oc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H26N4O4/c1-15-10-18(12-20-22(15)32-24(30)28(20)2)17-6-4-16(5-7-17)11-19(13-25)27-23(29)21-14-26-8-3-9-31-21/h4-7,10,12,19,21,26H,3,8-9,11,14H2,1-2H3,(H,27,29)/t19-,21-/m0/s1 WCWJGAFMGPMBQG-FPOVZHCZSA-N 50195240 CHEMBL3960432::US10287258, Example 3::US10669245, Example 3::US11117874, Example 3::US11655221, Example 3::US11680049, Example 3 Dipeptidyl peptidase 1 7.9 ChEMBL 10.1021/acs.jmedchem.6b01127 10.7270/Q2Z321K4 27690432 Connolly, S; Lönn, H; Käck, H; Van de Poël, A; Dahl, G; Doyle, K; Gardiner, P; Root, J; Wikell, C; Johannesson, P; Stenvall, K; Swallow, S CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195240&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253824 375977095 CHEMBL3960432 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50521492 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2scnc2c1)C#N)[C@@H]1CNCCCO1 InChI=1S/C22H22N4O2S/c23-12-18(26-22(27)20-13-24-8-1-9-28-20)10-15-2-4-16(5-3-15)17-6-7-21-19(11-17)25-14-29-21/h2-7,11,14,18,20,24H,1,8-10,13H2,(H,26,27)/t18-,20-/m0/s1 MUTKXUKCDAFWLB-ICSRJNTNSA-N 50195263 CHEMBL3942969::US10287258, Example 33::US10669245, Example 33::US11117874, Example 33::US11673871, Example 33::US11680049, Example 33 Dipeptidyl peptidase 1 63 ChEMBL 10.1021/acs.jmedchem.6b01127 10.7270/Q2Z321K4 27690432 Connolly, S; Lönn, H; Käck, H; Van de Poël, A; Dahl, G; Doyle, K; Gardiner, P; Root, J; Wikell, C; Johannesson, P; Stenvall, K; Swallow, S CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195263&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253877 375977118 CHEMBL3942969 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 50521493 FC(F)Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H24F2N4O4/c25-22(26)14-30-19-11-17(6-7-20(19)34-24(30)32)16-4-2-15(3-5-16)10-18(12-27)29-23(31)21-13-28-8-1-9-33-21/h2-7,11,18,21-22,28H,1,8-10,13-14H2,(H,29,31)/t18-,21-/m0/s1 ANPJTTUBCRFBKA-RXVVDRJESA-N 50195248 CHEMBL3891374::US10287258, Example 27::US10669245, Example 27::US11117874, Example 27::US11655221, Example 27::US11680049, Example 27 Dipeptidyl peptidase 1 6.3 ChEMBL 10.1021/acs.jmedchem.6b01127 10.7270/Q2Z321K4 27690432 Connolly, S; Lönn, H; Käck, H; Van de Poël, A; Dahl, G; Doyle, K; Gardiner, P; Root, J; Wikell, C; Johannesson, P; Stenvall, K; Swallow, S CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195248 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195248&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253888 375977103 CHEMBL3891374 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51020586 N#CN1CCCC1 InChI=1S/C5H8N2/c6-5-7-3-1-2-4-7/h1-4H2 QJRYYOWARFCJQZ-UHFFFAOYSA-N 50095495 CHEMBL262697::Pyrrolidine-1-carbonitrile Dipeptidyl peptidase 1 >25118.86 ChEMBL 10.1021/ml100212k 10.7270/Q2RX9DBM 24900293 Lainé, D; Palovich, M; McCleland, B; Petitjean, E; Delhom, I; Xie, H; Deng, J; Lin, G; Davis, R; Jolit, A; Nevins, N; Zhao, B; Villa, J; Schneck, J; McDevitt, P; Midgett, R; Kmett, C; Umbrecht, S; Peck, B; Davis, AB; Bettoun, D TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50095495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50095495&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 73737 103993152 CHEMBL262697 ZINC01676633 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51020587 N#CN1CCCC(CCc2ccccc2)C1 InChI=1S/C14H18N2/c15-12-16-10-4-7-14(11-16)9-8-13-5-2-1-3-6-13/h1-3,5-6,14H,4,7-11H2 DGBNMHOKWPUFOV-UHFFFAOYSA-N 50417988 CHEMBL1672420 Dipeptidyl peptidase 1 >25118.86 ChEMBL 10.1021/ml100212k 10.7270/Q2RX9DBM 24900293 Lainé, D; Palovich, M; McCleland, B; Petitjean, E; Delhom, I; Xie, H; Deng, J; Lin, G; Davis, R; Jolit, A; Nevins, N; Zhao, B; Villa, J; Schneck, J; McDevitt, P; Midgett, R; Kmett, C; Umbrecht, S; Peck, B; Davis, AB; Bettoun, D TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50417988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50417988&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 53317529 163367012 CHEMBL1672420 ZINC66073721 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51020588 O=S(=O)(N[C@@H]1CCN(C1)C#N)c1ccccc1 InChI=1S/C11H13N3O2S/c12-9-14-7-6-10(8-14)13-17(15,16)11-4-2-1-3-5-11/h1-5,10,13H,6-8H2/t10-/m1/s1 FXILBKWGQQHVJE-SNVBAGLBSA-N 50417989 CHEMBL1672422::US11414402, Example 7 Dipeptidyl peptidase 1 316.23 ChEMBL 10.1021/ml100212k 10.7270/Q2RX9DBM 24900293 Lainé, D; Palovich, M; McCleland, B; Petitjean, E; Delhom, I; Xie, H; Deng, J; Lin, G; Davis, R; Jolit, A; Nevins, N; Zhao, B; Villa, J; Schneck, J; McDevitt, P; Midgett, R; Kmett, C; Umbrecht, S; Peck, B; Davis, AB; Bettoun, D TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50417989 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50417989&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 53324300 163367013 CHEMBL1672422 ZINC03994220 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51020589 O=C(N[C@@H]1CCN(C1)C#N)Nc1ccccc1 InChI=1S/C12H14N4O/c13-9-16-7-6-11(8-16)15-12(17)14-10-4-2-1-3-5-10/h1-5,11H,6-8H2,(H2,14,15,17)/t11-/m1/s1 ORYZNHBPJFZGJG-LLVKDONJSA-N 50417990 CHEMBL1672424 Dipeptidyl peptidase 1 1000 ChEMBL 10.1021/ml100212k 10.7270/Q2RX9DBM 24900293 Lainé, D; Palovich, M; McCleland, B; Petitjean, E; Delhom, I; Xie, H; Deng, J; Lin, G; Davis, R; Jolit, A; Nevins, N; Zhao, B; Villa, J; Schneck, J; McDevitt, P; Midgett, R; Kmett, C; Umbrecht, S; Peck, B; Davis, AB; Bettoun, D TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50417990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50417990&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 53317737 163367014 CHEMBL1672424 ZINC34613828 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51020590 Brc1cccc(c1)S(=O)(=O)N[C@@H]1CCN(C1)C#N InChI=1S/C11H12BrN3O2S/c12-9-2-1-3-11(6-9)18(16,17)14-10-4-5-15(7-10)8-13/h1-3,6,10,14H,4-5,7H2/t10-/m1/s1 XCTNQGKKNUPDFM-SNVBAGLBSA-N 50417991 CHEMBL1672425 Dipeptidyl peptidase 1 7.94 ChEMBL 10.1021/ml100212k 10.7270/Q2RX9DBM 24900293 Lainé, D; Palovich, M; McCleland, B; Petitjean, E; Delhom, I; Xie, H; Deng, J; Lin, G; Davis, R; Jolit, A; Nevins, N; Zhao, B; Villa, J; Schneck, J; McDevitt, P; Midgett, R; Kmett, C; Umbrecht, S; Peck, B; Davis, AB; Bettoun, D TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50417991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50417991&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 44465454 163367015 CHEMBL1672425 ZINC66099237 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51020591 Brc1cccc(c1)S(=O)(=O)N[C@@H]1CCN(C1)C=O InChI=1S/C11H13BrN2O3S/c12-9-2-1-3-11(6-9)18(16,17)13-10-4-5-14(7-10)8-15/h1-3,6,8,10,13H,4-5,7H2/t10-/m1/s1 ZWRWGKYOVIYWBQ-SNVBAGLBSA-N 50417992 CHEMBL1672428 Dipeptidyl peptidase 1 >25118.86 ChEMBL 10.1021/ml100212k 10.7270/Q2RX9DBM 24900293 Lainé, D; Palovich, M; McCleland, B; Petitjean, E; Delhom, I; Xie, H; Deng, J; Lin, G; Davis, R; Jolit, A; Nevins, N; Zhao, B; Villa, J; Schneck, J; McDevitt, P; Midgett, R; Kmett, C; Umbrecht, S; Peck, B; Davis, AB; Bettoun, D TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50417992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50417992&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 53317530 163367016 CHEMBL1672428 ZINC66099241 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51020592 C[C@@H]1C[C@H](CN1C#N)NS(=O)(=O)c1cccc(Br)c1 InChI=1S/C12H14BrN3O2S/c1-9-5-11(7-16(9)8-14)15-19(17,18)12-4-2-3-10(13)6-12/h2-4,6,9,11,15H,5,7H2,1H3/t9-,11-/m1/s1 ORFRHRXPOJVPSF-MWLCHTKSSA-N 50417993 CHEMBL1672430 Dipeptidyl peptidase 1 15848.93 ChEMBL 10.1021/ml100212k 10.7270/Q2RX9DBM 24900293 Lainé, D; Palovich, M; McCleland, B; Petitjean, E; Delhom, I; Xie, H; Deng, J; Lin, G; Davis, R; Jolit, A; Nevins, N; Zhao, B; Villa, J; Schneck, J; McDevitt, P; Midgett, R; Kmett, C; Umbrecht, S; Peck, B; Davis, AB; Bettoun, D TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50417993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50417993&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 53318817 163367017 CHEMBL1672430 ZINC66099244 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51020593 COc1ccc(OC)c(c1)S(=O)(=O)N[C@@H]1C[C@@H](C)N(C1)C#N InChI=1S/C14H19N3O4S/c1-10-6-11(8-17(10)9-15)16-22(18,19)14-7-12(20-2)4-5-13(14)21-3/h4-5,7,10-11,16H,6,8H2,1-3H3/t10-,11-/m1/s1 OBODFDBEYMKZMM-GHMZBOCLSA-N 50417994 CHEMBL1672431 Dipeptidyl peptidase 1 >25118.86 ChEMBL 10.1021/ml100212k 10.7270/Q2RX9DBM 24900293 Lainé, D; Palovich, M; McCleland, B; Petitjean, E; Delhom, I; Xie, H; Deng, J; Lin, G; Davis, R; Jolit, A; Nevins, N; Zhao, B; Villa, J; Schneck, J; McDevitt, P; Midgett, R; Kmett, C; Umbrecht, S; Peck, B; Davis, AB; Bettoun, D TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50417994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50417994&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 53325394 163367018 CHEMBL1672431 ZINC66099245 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51020594 COc1ccc(OC)c(c1)S(=O)(=O)N[C@@H]1C[C@H](C)N(C1)C#N InChI=1S/C14H19N3O4S/c1-10-6-11(8-17(10)9-15)16-22(18,19)14-7-12(20-2)4-5-13(14)21-3/h4-5,7,10-11,16H,6,8H2,1-3H3/t10-,11+/m0/s1 OBODFDBEYMKZMM-WDEREUQCSA-N 50417995 CHEMBL1672433 Dipeptidyl peptidase 1 125.89 ChEMBL 10.1021/ml100212k 10.7270/Q2RX9DBM 24900293 Lainé, D; Palovich, M; McCleland, B; Petitjean, E; Delhom, I; Xie, H; Deng, J; Lin, G; Davis, R; Jolit, A; Nevins, N; Zhao, B; Villa, J; Schneck, J; McDevitt, P; Midgett, R; Kmett, C; Umbrecht, S; Peck, B; Davis, AB; Bettoun, D TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50417995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50417995&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 53318818 163367019 CHEMBL1672433 ZINC66079913 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51020595 C[C@H]1C[C@H](CN1C#N)NS(=O)(=O)c1cc(Br)ccc1Br InChI=1S/C12H13Br2N3O2S/c1-8-4-10(6-17(8)7-15)16-20(18,19)12-5-9(13)2-3-11(12)14/h2-3,5,8,10,16H,4,6H2,1H3/t8-,10+/m0/s1 XOGLUHPWGGYHRM-WCBMZHEXSA-N 50417996 CHEMBL1672434 Dipeptidyl peptidase 1 2 ChEMBL 10.1021/ml100212k 10.7270/Q2RX9DBM 24900293 Lainé, D; Palovich, M; McCleland, B; Petitjean, E; Delhom, I; Xie, H; Deng, J; Lin, G; Davis, R; Jolit, A; Nevins, N; Zhao, B; Villa, J; Schneck, J; McDevitt, P; Midgett, R; Kmett, C; Umbrecht, S; Peck, B; Davis, AB; Bettoun, D TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50417996 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50417996&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 25174148 163367020 CHEMBL1672434 ZINC43202870 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500496 Fc1cc(F)c2[nH]c(=O)c3cc(CC(NC(=O)[C@H]4N[C@@H]5CC[C@H]4C5)C#N)ccc3c2c1 150636 US10238633, Example 310::US8987249, 310::US9713606, 310 Dipeptidyl peptidase 1 9.40 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150636 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150636&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937218 252824887 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500497 COC(=O)c1cccc2c1[nH]c(=O)c1cc(CC(NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)ccc21 150637 US10238633, Example 311::US8987249, 311::US9713606, 311 Dipeptidyl peptidase 1 9.90 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150637 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150637&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937219 252824888 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500498 COc1ccc2[nH]c(=O)c3cc(CC(NC(=O)[C@H]4N[C@@H]5CC[C@H]4C5)C#N)ccc3c2c1 150638 US10238633, Example 312::US8987249, 312::US9713606, 312 Dipeptidyl peptidase 1 11.0 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150638 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150638&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937220 252824889 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51020648 N#CN1CCC(CCc2ccccc2)C1 InChI=1S/C13H16N2/c14-11-15-9-8-13(10-15)7-6-12-4-2-1-3-5-12/h1-5,13H,6-10H2 OWHQGUFRPCWXJH-UHFFFAOYSA-N 50418003 CHEMBL1672419 Dipeptidyl peptidase 1 1995.26 ChEMBL 10.1021/ml100212k 10.7270/Q2RX9DBM 24900293 Lainé, D; Palovich, M; McCleland, B; Petitjean, E; Delhom, I; Xie, H; Deng, J; Lin, G; Davis, R; Jolit, A; Nevins, N; Zhao, B; Villa, J; Schneck, J; McDevitt, P; Midgett, R; Kmett, C; Umbrecht, S; Peck, B; Davis, AB; Bettoun, D TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50418003 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50418003&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 53317528 163367027 CHEMBL1672419 ZINC66074042 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51020649 O=S(=O)(N[C@H]1CCN(C1)C#N)c1ccccc1 InChI=1S/C11H13N3O2S/c12-9-14-7-6-10(8-14)13-17(15,16)11-4-2-1-3-5-11/h1-5,10,13H,6-8H2/t10-/m0/s1 FXILBKWGQQHVJE-JTQLQIEISA-N 50418001 CHEMBL1672421::US11414402, Example 6 Dipeptidyl peptidase 1 316.23 ChEMBL 10.1021/ml100212k 10.7270/Q2RX9DBM 24900293 Lainé, D; Palovich, M; McCleland, B; Petitjean, E; Delhom, I; Xie, H; Deng, J; Lin, G; Davis, R; Jolit, A; Nevins, N; Zhao, B; Villa, J; Schneck, J; McDevitt, P; Midgett, R; Kmett, C; Umbrecht, S; Peck, B; Davis, AB; Bettoun, D TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50418001 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50418001&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 53326656 163367025 CHEMBL1672421 ZINC00008873 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51020650 Fc1ccc(cc1)C(=O)N[C@@H]1CCN(C1)C#N InChI=1S/C12H12FN3O/c13-10-3-1-9(2-4-10)12(17)15-11-5-6-16(7-11)8-14/h1-4,11H,5-7H2,(H,15,17)/t11-/m1/s1 MWHXRJQRAIXADX-LLVKDONJSA-N 50417997 CHEMBL1672423 Dipeptidyl peptidase 1 2511.89 ChEMBL 10.1021/ml100212k 10.7270/Q2RX9DBM 24900293 Lainé, D; Palovich, M; McCleland, B; Petitjean, E; Delhom, I; Xie, H; Deng, J; Lin, G; Davis, R; Jolit, A; Nevins, N; Zhao, B; Villa, J; Schneck, J; McDevitt, P; Midgett, R; Kmett, C; Umbrecht, S; Peck, B; Davis, AB; Bettoun, D TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50417997 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50417997&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 53322753 163367021 CHEMBL1672423 ZINC66074742 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51020651 COc1ccc(OC)c(c1)S(=O)(=O)N[C@@H]1CCN(C1)C#N InChI=1S/C13H17N3O4S/c1-19-11-3-4-12(20-2)13(7-11)21(17,18)15-10-5-6-16(8-10)9-14/h3-4,7,10,15H,5-6,8H2,1-2H3/t10-/m1/s1 SRQKADSCZJGWOI-SNVBAGLBSA-N 50417998 CHEMBL1672426 Dipeptidyl peptidase 1 10 ChEMBL 10.1021/ml100212k 10.7270/Q2RX9DBM 24900293 Lainé, D; Palovich, M; McCleland, B; Petitjean, E; Delhom, I; Xie, H; Deng, J; Lin, G; Davis, R; Jolit, A; Nevins, N; Zhao, B; Villa, J; Schneck, J; McDevitt, P; Midgett, R; Kmett, C; Umbrecht, S; Peck, B; Davis, AB; Bettoun, D TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50417998 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50417998&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 44464926 163367022 CHEMBL1672426 ZINC66066027 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51020652 CC(C)(C)OC(=O)N1CC[C@H](C1)NS(=O)(=O)c1cccc(Br)c1 InChI=1S/C15H21BrN2O4S/c1-15(2,3)22-14(19)18-8-7-12(10-18)17-23(20,21)13-6-4-5-11(16)9-13/h4-6,9,12,17H,7-8,10H2,1-3H3/t12-/m1/s1 DCDJYOKHGSLWKA-GFCCVEGCSA-N 50417999 CHEMBL1672429 Dipeptidyl peptidase 1 >25118.86 ChEMBL 10.1021/ml100212k 10.7270/Q2RX9DBM 24900293 Lainé, D; Palovich, M; McCleland, B; Petitjean, E; Delhom, I; Xie, H; Deng, J; Lin, G; Davis, R; Jolit, A; Nevins, N; Zhao, B; Villa, J; Schneck, J; McDevitt, P; Midgett, R; Kmett, C; Umbrecht, S; Peck, B; Davis, AB; Bettoun, D TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50417999 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50417999&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 53318816 163367023 CHEMBL1672429 ZINC66099242 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51020653 C[C@H]1C[C@H](CN1C#N)NS(=O)(=O)c1cccc(Br)c1 InChI=1S/C12H14BrN3O2S/c1-9-5-11(7-16(9)8-14)15-19(17,18)12-4-2-3-10(13)6-12/h2-4,6,9,11,15H,5,7H2,1H3/t9-,11+/m0/s1 ORFRHRXPOJVPSF-GXSJLCMTSA-N 50418000 CHEMBL1672432 Dipeptidyl peptidase 1 158.49 ChEMBL 10.1021/ml100212k 10.7270/Q2RX9DBM 24900293 Lainé, D; Palovich, M; McCleland, B; Petitjean, E; Delhom, I; Xie, H; Deng, J; Lin, G; Davis, R; Jolit, A; Nevins, N; Zhao, B; Villa, J; Schneck, J; McDevitt, P; Midgett, R; Kmett, C; Umbrecht, S; Peck, B; Davis, AB; Bettoun, D TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50418000 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50418000&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 25195691 163367024 CHEMBL1672432 ZINC59047693 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500499 CS(=O)(=O)c1ccc2[nH]c(=O)c3cc(CC(NC(=O)[C@H]4N[C@@H]5CC[C@H]4C5)C#N)ccc3c2c1 150639 US10238633, Example 313::US8987249, 313::US9713606, 313 Dipeptidyl peptidase 1 13.6 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150639 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150639&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937221 252824890 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500500 Nc1ccc2[nH]c(=O)c3cc(CC(NC(=O)[C@H]4N[C@@H]5CC[C@H]4C5)C#N)ccc3c2c1 150640 US10238633, Example 314::US8987249, 314::US9713606, 314 Dipeptidyl peptidase 1 14.0 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150640 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150640&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937222 252824891 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500501 Fc1ccc2c(c1)ncc1cc(CC(NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)ccc21 InChI=1S/C23H21FN4O/c24-16-3-6-20-19-5-1-13(7-15(19)12-26-21(20)10-16)8-18(11-25)28-23(29)22-14-2-4-17(9-14)27-22/h1,3,5-7,10,12,14,17-18,22,27H,2,4,8-9H2,(H,28,29)/t14-,17+,18?,22-/m0/s1 QJNLKABXJHEPTA-IHQHAJGLSA-N 150641 US10238633, Example 315::US8987249, 315::US9713606, 315 Dipeptidyl peptidase 1 13.5 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150641 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150641&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90414194 252824892 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500502 O=C(NC(Cc1ccc2c(cnc3ccccc23)c1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C23H22N4O/c24-12-18(27-23(28)22-15-6-7-17(11-15)26-22)10-14-5-8-19-16(9-14)13-25-21-4-2-1-3-20(19)21/h1-5,8-9,13,15,17-18,22,26H,6-7,10-11H2,(H,27,28)/t15-,17+,18?,22-/m0/s1 PKYHSYLOBVYURX-JJOTWVSXSA-N 150642 US10238633, Example 316::US8987249, 316::US9713606, 316 Dipeptidyl peptidase 1 42.4 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150642 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150642&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430270 252824893 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500503 Oc1cccc(n1)-c1ccc(F)c(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c1 InChI=1S/C21H21FN4O2/c22-17-7-5-12(18-2-1-3-19(27)26-18)8-14(17)10-16(11-23)25-21(28)20-13-4-6-15(9-13)24-20/h1-3,5,7-8,13,15-16,20,24H,4,6,9-10H2,(H,25,28)(H,26,27)/t13-,15+,16-,20-/m0/s1 IDXWFRRWRADIAT-YEOLMYPVSA-N 150643 US8987249, 317::US9713606, 317 Dipeptidyl peptidase 1 52.0 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150643 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150643&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430275 252824894 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500504 CN1CCN(CC1)c1ccc(F)c(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c1 InChI=1S/C21H28FN5O/c1-26-6-8-27(9-7-26)18-4-5-19(22)15(12-18)11-17(13-23)25-21(28)20-14-2-3-16(10-14)24-20/h4-5,12,14,16-17,20,24H,2-3,6-11H2,1H3,(H,25,28)/t14-,16+,17-,20-/m0/s1 YHGGOZOSHZJPNN-FORWCCJISA-N 150644 US10238633, Example 318::US8987249, 318::US9713606, 318 Dipeptidyl peptidase 1 212 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150644 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150644&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430269 252824895 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500505 CN1CCC(CC1)Oc1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H29FN4O2/c1-27-8-6-18(7-9-27)29-19-5-3-14(20(23)12-19)10-17(13-24)26-22(28)21-15-2-4-16(11-15)25-21/h3,5,12,15-18,21,25H,2,4,6-11H2,1H3,(H,26,28)/t15-,16+,17-,21-/m0/s1 HYUGWMVHDPXQBJ-DLRJPAPCSA-N 150645 US10238633, Example 319::US8987249, 319::US9713606, 319 Dipeptidyl peptidase 1 17.5 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150645 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150645&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90413630 252824896 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500506 CCN1CCC(=CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H29FN4O/c1-2-28-9-7-15(8-10-28)16-3-4-17(21(24)13-16)11-20(14-25)27-23(29)22-18-5-6-19(12-18)26-22/h3-4,7,13,18-20,22,26H,2,5-6,8-12H2,1H3,(H,27,29)/t18-,19+,20-,22-/m0/s1 OZZNAKFBQUXBQF-IIZPIQPGSA-N 150646 US10238633, Example 320::US8987249, 320::US9713606, 320 Dipeptidyl peptidase 1 9.60 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150646 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150646&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430274 252824897 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500507 CN1CCC(C)(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H31FN4O/c1-23(7-9-28(2)10-8-23)17-5-3-15(20(24)13-17)11-19(14-25)27-22(29)21-16-4-6-18(12-16)26-21/h3,5,13,16,18-19,21,26H,4,6-12H2,1-2H3,(H,27,29)/t16-,18+,19-,21-/m0/s1 WMXMRYCYIHGDFQ-KRQVXIAISA-N 150647 US10238633, Example 321::US8987249, 321::US9713606, 321 Dipeptidyl peptidase 1 56.8 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150647 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150647&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430259 252824898 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500508 Fc1cc2c3ccccc3[nH]c(=O)c2cc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N 150648 US10238633, Example 322::US8987249, 322::US9713606, 322 Dipeptidyl peptidase 1 0.800 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150648 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150648&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937223 252824899 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500509 Fc1ccc2c(c1)[nH]c(=O)c1cc(C[C@H](NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)c(F)cc21 150649 US10238633, Example 323::US8987249, 323::US9713606, 323 Dipeptidyl peptidase 1 0.800 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150649 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150649&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937224 252824900 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500510 Fc1ccc2c3cc(F)c(C[C@H](NC(=O)[C@H]4N[C@@H]5CC[C@H]4C5)C#N)cc3c(=O)[nH]c2c1F 150650 US10238633, Example 324::US8987249, 324::US9713606, 324 Dipeptidyl peptidase 1 1.000 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150650 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150650&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937225 252824901 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500511 Fc1cc2c3cc(cc(F)c3[nH]c(=O)c2cc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)C#N 150651 US10238633, Example 325::US8987249, 325::US9713606, 325 Dipeptidyl peptidase 1 1.30 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150651 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150651&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937226 252824902 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500512 Cn1c2ccccc2c2cc(F)c(C[C@H](NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)cc2c1=O InChI=1S/C24H23FN4O2/c1-29-21-5-3-2-4-17(21)18-11-20(25)14(10-19(18)24(29)31)9-16(12-26)28-23(30)22-13-6-7-15(8-13)27-22/h2-5,10-11,13,15-16,22,27H,6-9H2,1H3,(H,28,30)/t13-,15+,16-,22-/m0/s1 WKTMNQATQFDGDF-IZGSKCEXSA-N 150652 US10238633, Example 326::US8987249, 326::US9713606, 326 Dipeptidyl peptidase 1 1.90 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150652 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150652&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430268 252824903 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500513 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CC2(CNC2)C1 InChI=1S/C21H26FN5O/c22-18-7-17(27-11-21(12-27)9-24-10-21)4-2-13(18)5-16(8-23)26-20(28)19-14-1-3-15(6-14)25-19/h2,4,7,14-16,19,24-25H,1,3,5-6,9-12H2,(H,26,28)/t14-,15+,16-,19-/m0/s1 YUZUVEKDYNDTLN-RCJHGTSTSA-N 150653 US10238633, Example 327::US8987249, 327::US9713606, 327 Dipeptidyl peptidase 1 3.40 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150653 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150653&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430656 252824904 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500514 CN1CC2CCC(C1)N2c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H30FN5O/c1-28-12-19-6-7-20(13-28)29(19)18-5-3-14(21(24)10-18)8-17(11-25)27-23(30)22-15-2-4-16(9-15)26-22/h3,5,10,15-17,19-20,22,26H,2,4,6-9,12-13H2,1H3,(H,27,30)/t15-,16+,17-,19?,20?,22-/m0/s1 HTGIRCXAILFFBK-DVFPXELVSA-N 150654 US10238633, Example 328::US8987249, 328::US9713606, 328 Dipeptidyl peptidase 1 4.20 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150654&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430746 252824905 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500515 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1C2CCC1CN(C2)C1CCOC1 InChI=1S/C26H34FN5O2/c27-24-11-20(32-21-5-6-22(32)14-31(13-21)23-7-8-34-15-23)4-2-16(24)9-19(12-28)30-26(33)25-17-1-3-18(10-17)29-25/h2,4,11,17-19,21-23,25,29H,1,3,5-10,13-15H2,(H,30,33)/t17-,18+,19-,21?,22?,23?,25-/m0/s1 CFVCLDGBQIROEH-FHVJXWHLSA-N 150655 US10238633, Example 329::US8987249, 329::US9713606, 329 Dipeptidyl peptidase 1 7.00 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150655&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430697 252824906 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500516 CN1CC2(C1)CN(C2)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H28FN5O/c1-27-10-22(11-27)12-28(13-22)18-5-3-14(19(23)8-18)6-17(9-24)26-21(29)20-15-2-4-16(7-15)25-20/h3,5,8,15-17,20,25H,2,4,6-7,10-13H2,1H3,(H,26,29)/t15-,16+,17-,20-/m0/s1 GZROAMVDJTZDHV-CLWJZODNSA-N 150656 US10238633, Example 330::US8987249, 330::US9713606, 330 Dipeptidyl peptidase 1 7.80 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150656 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150656&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430645 252824907 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500517 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCN(CC1)C1CCOC1 InChI=1S/C24H32FN5O2/c25-22-13-20(29-6-8-30(9-7-29)21-5-10-32-15-21)4-2-16(22)11-19(14-26)28-24(31)23-17-1-3-18(12-17)27-23/h2,4,13,17-19,21,23,27H,1,3,5-12,15H2,(H,28,31)/t17-,18+,19-,21?,23-/m0/s1 HQPKYHAECKWQKT-BRJVMOAUSA-N 150657 US10238633, Example 331::US8987249, 331::US9713606, 331 Dipeptidyl peptidase 1 9.30 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150657 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150657&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430646 252824908 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500518 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)C1=CCN(CC1)C1CCOC1 InChI=1S/C25H31FN4O2/c26-23-13-17(16-5-8-30(9-6-16)22-7-10-32-15-22)1-2-18(23)11-21(14-27)29-25(31)24-19-3-4-20(12-19)28-24/h1-2,5,13,19-22,24,28H,3-4,6-12,15H2,(H,29,31)/t19-,20+,21-,22?,24-/m0/s1 HPIWKFZLWFOWST-NMZQLUBISA-N 150658 US10238633, Example 332::US8987249, 332::US9713606, 332 Dipeptidyl peptidase 1 12.9 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150658 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150658&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430834 252824909 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500519 CN1C2CCC1CN(C2)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H30FN5O/c1-28-19-6-7-20(28)13-29(12-19)18-5-3-14(21(24)10-18)8-17(11-25)27-23(30)22-15-2-4-16(9-15)26-22/h3,5,10,15-17,19-20,22,26H,2,4,6-9,12-13H2,1H3,(H,27,30)/t15-,16+,17-,19?,20?,22-/m0/s1 AFPYZOMVCKOSFX-DVFPXELVSA-N 150659 US10238633, Example 333::US8987249, 333::US9713606, 333 Dipeptidyl peptidase 1 15.3 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150659 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150659&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430881 252824910 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500520 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2N(C3CCNCC3)C(=O)Cc2c1 InChI=1S/C29H32FN5O2/c30-25-14-18(17-4-6-26-21(11-17)15-27(36)35(26)24-7-9-32-10-8-24)1-2-19(25)12-23(16-31)34-29(37)28-20-3-5-22(13-20)33-28/h1-2,4,6,11,14,20,22-24,28,32-33H,3,5,7-10,12-13,15H2,(H,34,37)/t20-,22+,23-,28-/m0/s1 DXRXGECGVNYTMC-HQGMYGGFSA-N 150660 US10238633, Example 334::US8987249, 334::US9713606, 334 Dipeptidyl peptidase 1 22.0 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150660 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150660&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430819 252824911 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500521 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCNCC1 InChI=1S/C20H26FN5O/c21-18-11-17(26-7-5-23-6-8-26)4-2-13(18)9-16(12-22)25-20(27)19-14-1-3-15(10-14)24-19/h2,4,11,14-16,19,23-24H,1,3,5-10H2,(H,25,27)/t14-,15+,16-,19-/m0/s1 IMHSIFFWUGPDKM-RCJHGTSTSA-N 150530 BDBM150661::US10238633, Example 335::US8987249, 204::US9713606, 335 Dipeptidyl peptidase 1 24.5 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150530&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430619 252824781 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500522 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCN(CC1)C1CCOCC1 InChI=1S/C25H34FN5O2/c26-23-15-22(31-9-7-30(8-10-31)21-5-11-33-12-6-21)4-2-17(23)13-20(16-27)29-25(32)24-18-1-3-19(14-18)28-24/h2,4,15,18-21,24,28H,1,3,5-14H2,(H,29,32)/t18-,19+,20-,24-/m0/s1 PVGDBPFKTDEZEI-VKDGWMQASA-N 150662 US10238633, Example 336::US8987249, 336::US9713606, 336 Dipeptidyl peptidase 1 24.5 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150662 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150662&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430857 252824913 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500523 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)C1CCN(CC1)C1CCOC1 InChI=1S/C25H33FN4O2/c26-23-13-17(16-5-8-30(9-6-16)22-7-10-32-15-22)1-2-18(23)11-21(14-27)29-25(31)24-19-3-4-20(12-19)28-24/h1-2,13,16,19-22,24,28H,3-12,15H2,(H,29,31)/t19-,20+,21-,22?,24-/m0/s1 WHIXYJGAWIPTFA-NMZQLUBISA-N 150663 US10238633, Example 337::US8987249, 337::US9713606, 337 Dipeptidyl peptidase 1 28.2 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150663 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150663&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430651 252824914 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500524 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)C1CCCN(C1)C1CCOC1 InChI=1S/C25H33FN4O2/c26-23-12-16(19-2-1-8-30(14-19)22-7-9-32-15-22)3-4-17(23)10-21(13-27)29-25(31)24-18-5-6-20(11-18)28-24/h3-4,12,18-22,24,28H,1-2,5-11,14-15H2,(H,29,31)/t18-,19?,20+,21-,22?,24-/m0/s1 PLDLYKGVWLEKJA-DQRHXDIBSA-N 150664 US10238633, Example 338::US8987249, 338::US9713606, 338 Dipeptidyl peptidase 1 44.3 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150664 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150664&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430828 252824915 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500525 CN1CCN(CC1)S(=O)(=O)c1cc(ccc1F)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C27H31F2N5O3S/c1-33-8-10-34(11-9-33)38(36,37)25-15-18(5-7-23(25)28)17-2-3-19(24(29)14-17)12-22(16-30)32-27(35)26-20-4-6-21(13-20)31-26/h2-3,5,7,14-15,20-22,26,31H,4,6,8-13H2,1H3,(H,32,35)/t20-,21+,22-,26-/m0/s1 TYOXDYZNTFEUBD-MSZDEVHKSA-N 150665 US10238633, Example 339::US8987249, 339::US9713606, 339 Dipeptidyl peptidase 1 1.30 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150665&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430640 252824916 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500526 CN1CCCN(CC1)S(=O)(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)C2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C28H34FN5O3S/c1-33-11-2-12-34(14-13-33)38(36,37)25-9-6-19(7-10-25)20-3-4-21(26(29)17-20)15-24(18-30)32-28(35)27-22-5-8-23(16-22)31-27/h3-4,6-7,9-10,17,22-24,27,31H,2,5,8,11-16H2,1H3,(H,32,35)/t22-,23+,24-,27?/m0/s1 LFMQCYRRSBXTCL-CEIMTJAFSA-N 263947 US9713606, 340 Dipeptidyl peptidase 1 1.80 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263947 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263947&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118970734 377002833 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500527 O=C(NC(Cc1ccc2c3cccc(C(=O)NC4CC4)c3[nH]c(=O)c2c1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 150667 US10238633, Example 341::US8987249, 341::US9713606, 341 Dipeptidyl peptidase 1 7.60 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150667 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150667&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937227 252824918 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500528 CN(C)CCn1cc(ccc1=O)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C25H30FN5O2/c1-30(2)9-10-31-15-19(6-8-23(31)32)16-3-4-17(22(26)13-16)11-21(14-27)29-25(33)24-18-5-7-20(12-18)28-24/h3-4,6,8,13,15,18,20-21,24,28H,5,7,9-12H2,1-2H3,(H,29,33)/t18-,20+,21-,24-/m0/s1 JCPYMYYDSFBUAQ-UQWVPHONSA-N 150668 US10238633, Example 342::US8987249, 342::US9713606, 342 Dipeptidyl peptidase 1 1.30 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150668 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150668&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430321 252824919 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500529 FC(F)Cn1cc(ccc1=O)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H23F3N4O2/c24-19-9-13(16-4-6-21(31)30(11-16)12-20(25)26)1-2-14(19)7-18(10-27)29-23(32)22-15-3-5-17(8-15)28-22/h1-2,4,6,9,11,15,17-18,20,22,28H,3,5,7-8,12H2,(H,29,32)/t15-,17+,18-,22-/m0/s1 XLDYHFLLFRGMMH-PBWVOLNLSA-N 150669 US10238633, Example 343::US8987249, 343::US9713606, 343 Dipeptidyl peptidase 1 4.50 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150669 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150669&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430361 252824920 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500530 CN(C)C1CCCN(C1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H32FN5O/c1-28(2)20-4-3-9-29(14-20)19-8-6-15(21(24)12-19)10-18(13-25)27-23(30)22-16-5-7-17(11-16)26-22/h6,8,12,16-18,20,22,26H,3-5,7,9-11,14H2,1-2H3,(H,27,30)/t16-,17+,18-,20?,22-/m0/s1 GDNGGGSHVJGZPQ-AEJWZEPGSA-N 150670 US10238633, Example 344::US8987249, 344::US9713606, 344 Dipeptidyl peptidase 1 10.00 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150670 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150670&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90413980 252824921 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500531 CN(C)CC1CCCN(C1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H34FN5O/c1-29(2)14-16-4-3-9-30(15-16)21-8-6-17(22(25)12-21)10-20(13-26)28-24(31)23-18-5-7-19(11-18)27-23/h6,8,12,16,18-20,23,27H,3-5,7,9-11,14-15H2,1-2H3,(H,28,31)/t16?,18-,19+,20-,23-/m0/s1 HSYBJTSDYKJCLC-XPNKYNLISA-N 150671 US10238633, Example 345::US8987249, 345::US9713606, 345 Dipeptidyl peptidase 1 18.4 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150671&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430377 252824922 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500532 CN1CCC(CC1)N1C(=O)Cc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C30H34FN5O2/c1-35-10-8-25(9-11-35)36-27-15-19(3-5-21(27)16-28(36)37)18-2-4-20(26(31)14-18)12-24(17-32)34-30(38)29-22-6-7-23(13-22)33-29/h2-5,14-15,22-25,29,33H,6-13,16H2,1H3,(H,34,38)/t22-,23+,24-,29-/m0/s1 NQWFIIUUUKGYJY-MVPDCNEZSA-N 150672 US10238633, Example 346::US8987249, 346::US9713606, 346 Dipeptidyl peptidase 1 1.000 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150672&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430825 252824923 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500533 CNc1nc2cc(ccc2[nH]1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 150673 US10238633, Example 347::US8987249, 347::US9713606, 347 Dipeptidyl peptidase 1 8.50 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150673&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430669 252824924 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500534 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CC2CCN(C3CCOC3)C2C1 InChI=1S/C26H34FN5O2/c27-23-11-21(31-13-18-5-7-32(24(18)14-31)22-6-8-34-15-22)4-2-16(23)9-20(12-28)30-26(33)25-17-1-3-19(10-17)29-25/h2,4,11,17-20,22,24-25,29H,1,3,5-10,13-15H2,(H,30,33)/t17-,18?,19+,20-,22?,24?,25-/m0/s1 HNERTVWQTUOXEG-QOCJVYAVSA-N 150674 US10238633, Example 348::US8987249, 348::US9713606, 348 Dipeptidyl peptidase 1 17.6 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150674 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150674&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430684 252824925 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500535 CN1CCC2CN(CC12)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H30FN5O/c1-28-7-6-16-12-29(13-21(16)28)19-5-3-14(20(24)10-19)8-18(11-25)27-23(30)22-15-2-4-17(9-15)26-22/h3,5,10,15-18,21-22,26H,2,4,6-9,12-13H2,1H3,(H,27,30)/t15-,16?,17+,18-,21?,22-/m0/s1 IJCSTYFRTDTKAN-CHXWQNPLSA-N 150675 US10238633, Example 349::US8987249, 349::US9713606, 349 Dipeptidyl peptidase 1 20.6 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150675&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430670 252824926 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500536 COCCN1CCC(C1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H31FN4O2/c1-30-9-8-28-7-6-18(14-28)15-2-3-16(21(24)12-15)10-20(13-25)27-23(29)22-17-4-5-19(11-17)26-22/h2-3,12,17-20,22,26H,4-11,14H2,1H3,(H,27,29)/t17-,18?,19+,20-,22-/m0/s1 IQICHZGNSROSIQ-FPTDZDEXSA-N 150676 US10238633, Example 350::US8987249, 350::US9713606, 350 Dipeptidyl peptidase 1 38.6 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150676&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430831 252824927 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500537 Fc1c(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)ccc2CC(CCc12)N1CCOCC1 InChI=1S/C24H31FN4O2/c25-22-16(11-19(14-26)28-24(30)23-17-3-4-18(12-17)27-23)2-1-15-13-20(5-6-21(15)22)29-7-9-31-10-8-29/h1-2,17-20,23,27H,3-13H2,(H,28,30)/t17-,18+,19-,20?,23-/m0/s1 AOFGEIPQRRXJES-AJOPTGRPSA-N 150677 US10238633, Example 351::US8987249, 351::US9713606, 351 Dipeptidyl peptidase 1 82.8 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150677&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430878 252824928 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500538 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCC2COCC2C1 InChI=1S/C23H29FN4O2/c24-21-9-20(28-6-5-16-12-30-13-17(16)11-28)4-2-14(21)7-19(10-25)27-23(29)22-15-1-3-18(8-15)26-22/h2,4,9,15-19,22,26H,1,3,5-8,11-13H2,(H,27,29)/t15-,16?,17?,18+,19-,22-/m0/s1 FJQGLLQSIMRVNW-MBJMIVNXSA-N 150678 US10238633, Example 352::US8987249, 352::US9713606, 352 Dipeptidyl peptidase 1 17.3 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150678&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430832 252824929 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500539 CN1CC2CCN(C2C1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H30FN5O/c1-28-12-16-6-7-29(21(16)13-28)19-5-3-14(20(24)10-19)8-18(11-25)27-23(30)22-15-2-4-17(9-15)26-22/h3,5,10,15-18,21-22,26H,2,4,6-9,12-13H2,1H3,(H,27,30)/t15-,16?,17+,18-,21?,22-/m0/s1 HEZSCOPWBZQUPX-CHXWQNPLSA-N 150679 US10238633, Example 353::US8987249, 353::US9713606, 353 Dipeptidyl peptidase 1 6.50 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150679&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430880 252824930 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500540 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCC2CN(CC12)C1CCOC1 InChI=1S/C26H34FN5O2/c27-23-11-21(32-7-5-18-13-31(14-24(18)32)22-6-8-34-15-22)4-2-16(23)9-20(12-28)30-26(33)25-17-1-3-19(10-17)29-25/h2,4,11,17-20,22,24-25,29H,1,3,5-10,13-15H2,(H,30,33)/t17-,18?,19+,20-,22?,24?,25-/m0/s1 FUQCVQPIQCQUJA-QOCJVYAVSA-N 150680 US10238633, Example 354::US8987249, 354::US9713606, 354 Dipeptidyl peptidase 1 6.80 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150680&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430818 252824931 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500541 CN1CCO[C@@H]2CN(C[C@H]12)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H30FN5O2/c1-28-6-7-31-21-13-29(12-20(21)28)18-5-3-14(19(24)10-18)8-17(11-25)27-23(30)22-15-2-4-16(9-15)26-22/h3,5,10,15-17,20-22,26H,2,4,6-9,12-13H2,1H3,(H,27,30)/t15-,16+,17-,20-,21+,22-/m0/s1 CQSOXMZXLHYZJS-MNJVBOLNSA-N 150681 US10238633, Example 355::US8987249, 355::US9713606, 355 Dipeptidyl peptidase 1 22.4 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150681&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430475 252824932 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500542 CN1CCO[C@@H]2CCN(C[C@H]12)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H32FN5O2/c1-29-8-9-32-22-6-7-30(14-21(22)29)19-5-3-15(20(25)12-19)10-18(13-26)28-24(31)23-16-2-4-17(11-16)27-23/h3,5,12,16-18,21-23,27H,2,4,6-11,14H2,1H3,(H,28,31)/t16-,17+,18-,21-,22+,23-/m0/s1 KTZQFVFLNYISOX-YNGMKWAISA-N 150682 US10238633, Example 356::US8987249, 356::US9713606, 356 Dipeptidyl peptidase 1 20.0 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150682&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430477 252824933 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500543 CN1CCO[C@H]2CN(CC[C@H]12)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H32FN5O2/c1-29-8-9-32-22-14-30(7-6-21(22)29)19-5-3-15(20(25)12-19)10-18(13-26)28-24(31)23-16-2-4-17(11-16)27-23/h3,5,12,16-18,21-23,27H,2,4,6-11,14H2,1H3,(H,28,31)/t16-,17+,18-,21-,22-,23-/m0/s1 LULCUNUDANTJSG-FVOHPSJWSA-N 150683 US10238633, Example 357::US8987249, 357::US9713606, 357 Dipeptidyl peptidase 1 33.8 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150683&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430480 252824934 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500544 CN1CCC2(CC(C2)c2ccc(C[C@H](NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)c(F)c2)CC1 InChI=1S/C25H33FN4O/c1-30-8-6-25(7-9-30)13-19(14-25)16-2-3-17(22(26)12-16)10-21(15-27)29-24(31)23-18-4-5-20(11-18)28-23/h2-3,12,18-21,23,28H,4-11,13-14H2,1H3,(H,29,31)/t18-,20+,21-,23-/m0/s1 VYUWIIULBHZCOM-SQMWVJLWSA-N 150684 US10238633, Example 358::US8987249, 358::US9713606, 358 Dipeptidyl peptidase 1 22.0 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150684 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150684&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430208 252824935 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 500545 CN1CCC2(CC(=C2)c2ccc(C[C@H](NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)c(F)c2)CC1 InChI=1S/C25H31FN4O/c1-30-8-6-25(7-9-30)13-19(14-25)16-2-3-17(22(26)12-16)10-21(15-27)29-24(31)23-18-4-5-20(11-18)28-23/h2-3,12-13,18,20-21,23,28H,4-11,14H2,1H3,(H,29,31)/t18-,20+,21-,23-/m0/s1 CVDOMISMJVCMHM-SQMWVJLWSA-N 150685 US10238633, Example 359::US8987249, 359::US9713606, 359 Dipeptidyl peptidase 1 8.80 6 25.00 C US Patent 10.7270/Q21G0P8M aid1795251 US9713606 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150685 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150685&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430211 252824936 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 480818 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2NC(=O)C3(CCNCC3)c2c1 InChI=1S/C28H30FN5O2/c29-23-14-17(16-4-6-24-22(13-16)28(27(36)34-24)7-9-31-10-8-28)1-2-18(23)11-21(15-30)33-26(35)25-19-3-5-20(12-19)32-25/h1-2,4,6,13-14,19-21,25,31-32H,3,5,7-12H2,(H,33,35)(H,34,36)/t19-,20+,21-,25-/m0/s1 WZYGEAFXJAOMCC-PDFGSZSQSA-N 201014 US9540373, 3::US9879026, Example 3::USRE47636, Example 3 Dipeptidyl peptidase 1 0.300 25.00 C US Patent 10.7270/Q2NK3C6R aid1795079 US9540373 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201014 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201014&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184938 375976338 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 480819 CN1C(=O)C2(CCNCC2)c2cc(ccc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C29H32FN5O2/c1-35-25-7-5-17(14-23(25)29(28(35)37)8-10-32-11-9-29)18-2-3-19(24(30)15-18)12-22(16-31)34-27(36)26-20-4-6-21(13-20)33-26/h2-3,5,7,14-15,20-22,26,32-33H,4,6,8-13H2,1H3,(H,34,36)/t20-,21+,22-,26-/m0/s1 CXEHWKQDWKZLQY-MSZDEVHKSA-N 201015 US9540373, 4::US9879026, Example 4::USRE47636, Example 4 Dipeptidyl peptidase 1 0.400 25.00 C US Patent 10.7270/Q2NK3C6R aid1795079 US9540373 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201015 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201015&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184939 375976339 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 480820 CN1C(=O)C2(CCN(C)CC2)c2cc(ccc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C30H34FN5O2/c1-35-11-9-30(10-12-35)24-15-18(6-8-26(24)36(2)29(30)38)19-3-4-20(25(31)16-19)13-23(17-32)34-28(37)27-21-5-7-22(14-21)33-27/h3-4,6,8,15-16,21-23,27,33H,5,7,9-14H2,1-2H3,(H,34,37)/t21-,22+,23-,27-/m0/s1 NFSMBZKEGKVOOI-GIRPNKPCSA-N 201016 US9540373, 5::US9879026, Example 5::USRE47636, Example 5 Dipeptidyl peptidase 1 0.600 25.00 C US Patent 10.7270/Q2NK3C6R aid1795079 US9540373 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201016&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184904 375976340 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 480821 CN1CCC2(CC1)C(=O)Nc1ccc(cc21)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C29H32FN5O2/c1-35-10-8-29(9-11-35)23-14-17(5-7-25(23)34-28(29)37)18-2-3-19(24(30)15-18)12-22(16-31)33-27(36)26-20-4-6-21(13-20)32-26/h2-3,5,7,14-15,20-22,26,32H,4,6,8-13H2,1H3,(H,33,36)(H,34,37)/t20-,21+,22-,26-/m0/s1 GANYKEOVXMYLES-MSZDEVHKSA-N 201017 US9540373, 6::US9879026, Example 6::USRE47636, Example 6 Dipeptidyl peptidase 1 0.200 25.00 C US Patent 10.7270/Q2NK3C6R aid1795079 US9540373 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201017&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184954 375976341 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 480822 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2C(=O)OC3(CCNCC3)c2c1 InChI=1S/C28H29FN4O3/c29-24-14-17(16-4-6-22-23(13-16)28(36-27(22)35)7-9-31-10-8-28)1-2-18(24)11-21(15-30)33-26(34)25-19-3-5-20(12-19)32-25/h1-2,4,6,13-14,19-21,25,31-32H,3,5,7-12H2,(H,33,34)/t19-,20+,21-,25-/m0/s1 ANLWAHOMUCKFHK-PDFGSZSQSA-N 201018 US9540373, 7::US9879026, Example 7::USRE47636, Example 7 Dipeptidyl peptidase 1 0.500 25.00 C US Patent 10.7270/Q2NK3C6R aid1795079 US9540373 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201018&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184955 375976342 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 480823 CN1CCC2(CC1)OC(=O)c1ccc(cc21)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C29H31FN4O3/c1-34-10-8-29(9-11-34)24-14-17(5-7-23(24)28(36)37-29)18-2-3-19(25(30)15-18)12-22(16-31)33-27(35)26-20-4-6-21(13-20)32-26/h2-3,5,7,14-15,20-22,26,32H,4,6,8-13H2,1H3,(H,33,35)/t20-,21+,22-,26-/m0/s1 HDXINRXLBDJTBO-MSZDEVHKSA-N 201019 US9540373, 8::US9879026, Example 8::USRE47636, Example 8 Dipeptidyl peptidase 1 0.700 25.00 C US Patent 10.7270/Q2NK3C6R aid1795079 US9540373 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201019 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201019&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184918 375976343 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 480824 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2C(=O)OC3(CCNC3)c2c1 InChI=1S/C27H27FN4O3/c28-23-12-16(15-4-6-21-22(11-15)27(35-26(21)34)7-8-30-14-27)1-2-17(23)9-20(13-29)32-25(33)24-18-3-5-19(10-18)31-24/h1-2,4,6,11-12,18-20,24,30-31H,3,5,7-10,14H2,(H,32,33)/t18-,19+,20-,24-,27?/m0/s1 IHLOZXJKAUYWCS-YRMZYPIJSA-N 201020 US9540373, 9::US9879026, Example 9::USRE47636, Example 9 Dipeptidyl peptidase 1 0.500 25.00 C US Patent 10.7270/Q2NK3C6R aid1795079 US9540373 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201020 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201020&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184927 375976344 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 480825 CN1CCC2(C1)OC(=O)c1ccc(cc21)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C28H29FN4O3/c1-33-9-8-28(15-33)23-12-16(5-7-22(23)27(35)36-28)17-2-3-18(24(29)13-17)10-21(14-30)32-26(34)25-19-4-6-20(11-19)31-25/h2-3,5,7,12-13,19-21,25,31H,4,6,8-11,15H2,1H3,(H,32,34)/t19-,20+,21-,25-,28?/m0/s1 GZDIEAVBMSLAOW-WWOCRAFXSA-N 201021 US9540373, 10::US9879026, Example 10::USRE47636, Example 10 Dipeptidyl peptidase 1 0.600 25.00 C US Patent 10.7270/Q2NK3C6R aid1795079 US9540373 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201021 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201021&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184917 375976345 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 480826 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2C(=O)OC3(CNC3)c2c1 InChI=1S/C26H25FN4O3/c27-22-10-15(14-4-6-20-21(9-14)26(12-29-13-26)34-25(20)33)1-2-16(22)7-19(11-28)31-24(32)23-17-3-5-18(8-17)30-23/h1-2,4,6,9-10,17-19,23,29-30H,3,5,7-8,12-13H2,(H,31,32)/t17-,18+,19-,23-/m0/s1 RZHGTZMOHTZJBI-YWNPBTLJSA-N 201022 US9540373, 11::US9879026, Example 11::USRE47636, Example 11 Dipeptidyl peptidase 1 0.700 25.00 C US Patent 10.7270/Q2NK3C6R aid1795079 US9540373 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201022 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201022&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184947 375976346 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 480827 CN1CC2(C1)OC(=O)c1ccc(cc21)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C27H27FN4O3/c1-32-13-27(14-32)22-10-15(5-7-21(22)26(34)35-27)16-2-3-17(23(28)11-16)8-20(12-29)31-25(33)24-18-4-6-19(9-18)30-24/h2-3,5,7,10-11,18-20,24,30H,4,6,8-9,13-14H2,1H3,(H,31,33)/t18-,19+,20-,24-/m0/s1 GWAYSZALTIDBDU-VKDGWMQASA-N 201023 US9540373, 12::US9879026, Example 12::USRE47636, Example 12 Dipeptidyl peptidase 1 0.500 25.00 C US Patent 10.7270/Q2NK3C6R aid1795079 US9540373 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201023&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184916 375976347 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 480828 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2COC3(CCNCC3)c2c1 InChI=1S/C28H31FN4O2/c29-25-14-18(17-2-4-21-16-35-28(24(21)13-17)7-9-31-10-8-28)1-3-19(25)11-23(15-30)33-27(34)26-20-5-6-22(12-20)32-26/h1-4,13-14,20,22-23,26,31-32H,5-12,16H2,(H,33,34)/t20-,22+,23-,26-/m0/s1 NGCHHBUOUZQOFZ-VBZBYZBJSA-N 201024 US9540373, 13::US9879026, Example 13::USRE47636, Example 13 Dipeptidyl peptidase 1 0.600 25.00 C US Patent 10.7270/Q2NK3C6R aid1795079 US9540373 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201024 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201024&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184898 375976348 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 480829 CN1CCC2(CC1)OCc1ccc(cc21)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C29H33FN4O2/c1-34-10-8-29(9-11-34)25-14-18(3-5-22(25)17-36-29)19-2-4-20(26(30)15-19)12-24(16-31)33-28(35)27-21-6-7-23(13-21)32-27/h2-5,14-15,21,23-24,27,32H,6-13,17H2,1H3,(H,33,35)/t21-,23+,24-,27-/m0/s1 LINMSXGSIPWEDG-DQHZSEARSA-N 201025 US9540373, 14::US9879026, Example 14::USRE47636, Example 14 Dipeptidyl peptidase 1 1.000 25.00 C US Patent 10.7270/Q2NK3C6R aid1795079 US9540373 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201025&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184899 375976349 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 480830 CN1CCC2(CCc3ccc(cc23)-c2ccc(C[C@H](NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)c(F)c2)CC1 InChI=1S/C30H35FN4O/c1-35-12-10-30(11-13-35)9-8-19-2-3-20(16-26(19)30)21-4-5-22(27(31)17-21)14-25(18-32)34-29(36)28-23-6-7-24(15-23)33-28/h2-5,16-17,23-25,28,33H,6-15H2,1H3,(H,34,36)/t23-,24+,25-,28-/m0/s1 QPILZBCBUNFEJW-GIBNYFNHSA-N 201026 US9540373, 15::US9879026, Example 15::USRE47636, Example 15 Dipeptidyl peptidase 1 0.500 25.00 C US Patent 10.7270/Q2NK3C6R aid1795079 US9540373 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201026&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184929 375976350 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 480831 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2NC(=O)C3(CCNC3)c2c1 InChI=1S/C27H28FN5O2/c28-22-12-16(15-4-6-23-21(11-15)27(26(35)33-23)7-8-30-14-27)1-2-17(22)9-20(13-29)32-25(34)24-18-3-5-19(10-18)31-24/h1-2,4,6,11-12,18-20,24,30-31H,3,5,7-10,14H2,(H,32,34)(H,33,35)/t18-,19+,20-,24-,27?/m0/s1 PPKDQAGFRUNTKU-YRMZYPIJSA-N 201027 US9540373, 16::US9879026, Example 16::USRE47636, Example 16 Dipeptidyl peptidase 1 0.500 25.00 C US Patent 10.7270/Q2NK3C6R aid1795079 US9540373 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201027&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184903 375976351 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 480832 CN1C(=O)C2(CCCN(C)C2)c2cc(ccc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C30H34FN5O2/c1-35-11-3-10-30(17-35)24-14-18(7-9-26(24)36(2)29(30)38)19-4-5-20(25(31)15-19)12-23(16-32)34-28(37)27-21-6-8-22(13-21)33-27/h4-5,7,9,14-15,21-23,27,33H,3,6,8,10-13,17H2,1-2H3,(H,34,37)/t21-,22+,23-,27-,30?/m0/s1 AAOICSZNQCRTDO-UALQKFLNSA-N 201028 US9540373, 17::US9879026, Example 17::USRE47636, Example 17 Dipeptidyl peptidase 1 1.60 25.00 C US Patent 10.7270/Q2NK3C6R aid1795079 US9540373 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201028&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184914 375976352 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 480833 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cc2c(cn1)C(=O)OC21CCNCC1 InChI=1S/C27H28FN5O3/c28-22-11-16(23-12-21-20(14-31-23)26(35)36-27(21)5-7-30-8-6-27)2-1-15(22)9-19(13-29)33-25(34)24-17-3-4-18(10-17)32-24/h1-2,11-12,14,17-19,24,30,32H,3-10H2,(H,33,34)/t17-,18+,19-,24-/m0/s1 SXKJOBWBROQYHC-YDLHNXBPSA-N 201029 US9540373, 18::US9879026, Example 18::USRE47636, Example 18 Dipeptidyl peptidase 1 1.60 25.00 C US Patent 10.7270/Q2NK3C6R aid1795079 US9540373 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201029&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184930 375976353 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 480834 CN1CCC2(CC1)OC(=O)c1cnc(cc21)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C28H30FN5O3/c1-34-8-6-28(7-9-34)22-13-24(31-15-21(22)27(36)37-28)17-3-2-16(23(29)12-17)10-20(14-30)33-26(35)25-18-4-5-19(11-18)32-25/h2-3,12-13,15,18-20,25,32H,4-11H2,1H3,(H,33,35)/t18-,19+,20-,25-/m0/s1 CLQRHMRHSRFUBH-ZDQHKECQSA-N 201030 US9540373, 19::US9879026, Example 19::USRE47636, Example 19 Dipeptidyl peptidase 1 1.000 25.00 C US Patent 10.7270/Q2NK3C6R aid1795079 US9540373 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201030&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184900 375976354 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 480835 CN1CCC2(C1)OC(=O)c1cnc(cc21)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C27H28FN5O3/c1-33-7-6-27(14-33)21-11-23(30-13-20(21)26(35)36-27)16-3-2-15(22(28)10-16)8-19(12-29)32-25(34)24-17-4-5-18(9-17)31-24/h2-3,10-11,13,17-19,24,31H,4-9,14H2,1H3,(H,32,34)/t17-,18+,19-,24-,27?/m0/s1 YZPZXQUEXBVKKM-IKHSKEIOSA-N 201031 US9540373, 20::US9879026, Example 20::USRE47636, Example 20 Dipeptidyl peptidase 1 1.60 25.00 C US Patent 10.7270/Q2NK3C6R aid1795079 US9540373 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201031&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184901 375976355 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 480836 CN1CCC2(CC1)OC(=O)c1ncc(cc21)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C28H30FN5O3/c1-34-8-6-28(7-9-34)22-12-19(15-31-25(22)27(36)37-28)16-2-3-17(23(29)13-16)10-21(14-30)33-26(35)24-18-4-5-20(11-18)32-24/h2-3,12-13,15,18,20-21,24,32H,4-11H2,1H3,(H,33,35)/t18-,20+,21-,24-/m0/s1 LQCCOFQTUNRXCK-UQWVPHONSA-N 201032 US9540373, 21::US9879026, Example 21::USRE47636, Example 21 Dipeptidyl peptidase 1 1.40 25.00 C US Patent 10.7270/Q2NK3C6R aid1795079 US9540373 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201032&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184956 375976356 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 480837 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cc2c(cn1)C(=O)OC21CCN(CC1)C1COC1 InChI=1S/C30H32FN5O4/c31-25-11-18(2-1-17(25)9-21(13-32)35-28(37)27-19-3-4-20(10-19)34-27)26-12-24-23(14-33-26)29(38)40-30(24)5-7-36(8-6-30)22-15-39-16-22/h1-2,11-12,14,19-22,27,34H,3-10,15-16H2,(H,35,37)/t19-,20+,21-,27-/m0/s1 JMHULBQBHVSKRL-WFQVPWNOSA-N 201033 US9540373, 22::US9879026, Example 22::USRE47636, Example 22 Dipeptidyl peptidase 1 4.80 25.00 C US Patent 10.7270/Q2NK3C6R aid1795079 US9540373 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201033&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184902 375976357 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 480838 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cc2c(COC22CCN(CC2)C2COC2)cn1 InChI=1S/C30H34FN5O3/c31-26-11-19(2-1-18(26)9-23(13-32)35-29(37)28-20-3-4-22(10-20)34-28)27-12-25-21(14-33-27)15-39-30(25)5-7-36(8-6-30)24-16-38-17-24/h1-2,11-12,14,20,22-24,28,34H,3-10,15-17H2,(H,35,37)/t20-,22+,23-,28-/m0/s1 VIDWRXWIFCHQDH-HQGMYGGFSA-N 201034 US9540373, 23::US9879026, Example 23::USRE47636, Example 23 Dipeptidyl peptidase 1 5.00 25.00 C US Patent 10.7270/Q2NK3C6R aid1795079 US9540373 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201034&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118939920 375976358 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 480839 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2C(=O)OC3(CCN(CC3)C3COC3)c2n1 InChI=1S/C30H32FN5O4/c31-24-13-18(2-1-17(24)11-21(14-32)34-28(37)26-19-3-4-20(12-19)33-26)25-6-5-23-27(35-25)30(40-29(23)38)7-9-36(10-8-30)22-15-39-16-22/h1-2,5-6,13,19-22,26,33H,3-4,7-12,15-16H2,(H,34,37)/t19-,20+,21-,26-/m0/s1 QDEUYXRXWLXIES-LMMUWCHVSA-N 201036 US9540373, 24::US9879026, Example 24::USRE47636, Example 24 Dipeptidyl peptidase 1 2.70 25.00 C US Patent 10.7270/Q2NK3C6R aid1795079 US9540373 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201036&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184892 375976359 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 480840 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2COC3(CCN(CC3)C3COC3)c2n1 InChI=1S/C30H34FN5O3/c31-25-13-19(2-1-18(25)11-23(14-32)34-29(37)27-20-3-5-22(12-20)33-27)26-6-4-21-15-39-30(28(21)35-26)7-9-36(10-8-30)24-16-38-17-24/h1-2,4,6,13,20,22-24,27,33H,3,5,7-12,15-17H2,(H,34,37)/t20-,22+,23-,27-/m0/s1 DJEHFUIVWJPRCP-XUTUTRJZSA-N 201037 US9540373, 25::US9879026, Example 25::USRE47636, Example 25 Dipeptidyl peptidase 1 1.80 25.00 C US Patent 10.7270/Q2NK3C6R aid1795079 US9540373 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201037 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201037&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118939923 375976360 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 480841 CN1CCC2(CC1)OCc1cnc(cc21)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C28H32FN5O2/c1-34-8-6-28(7-9-34)23-13-25(31-15-20(23)16-36-28)18-3-2-17(24(29)12-18)10-22(14-30)33-27(35)26-19-4-5-21(11-19)32-26/h2-3,12-13,15,19,21-22,26,32H,4-11,16H2,1H3,(H,33,35)/t19-,21+,22-,26-/m0/s1 LPWVDJUWYBLVEL-IYCJUYGXSA-N 201549 US9540373, 26::US9879026, Example 26::USRE47636, Example 26 Dipeptidyl peptidase 1 2.00 25.00 C US Patent 10.7270/Q2NK3C6R aid1795079 US9540373 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201549 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201549&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118939916 375976361 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 480842 Fc1cc(ccc1C[C@H](NC(=O)C12CCC(CC1)CN2)C#N)-c1ccc2COC3(CCN(CC3)C3COC3)c2c1 InChI=1S/C32H37FN4O3/c33-29-15-23(1-3-24(29)13-26(16-34)36-30(38)31-7-5-21(6-8-31)17-35-31)22-2-4-25-18-40-32(28(25)14-22)9-11-37(12-10-32)27-19-39-20-27/h1-4,14-15,21,26-27,35H,5-13,17-20H2,(H,36,38)/t21?,26-,31?/m0/s1 VCBLPORJGXYQEJ-YVWBODOZSA-N 201550 US9540373, 27::US9879026, Example 27::USRE47636, Example 27 Dipeptidyl peptidase 1 2.90 25.00 C US Patent 10.7270/Q2NK3C6R aid1795079 US9540373 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201550 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201550&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118939927 375976362 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 480816 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2COC3(CCN(CC3)C3COC3)c2c1 InChI=1S/C31H35FN4O3/c32-28-14-20(1-3-21(28)11-25(15-33)35-30(37)29-22-5-6-24(12-22)34-29)19-2-4-23-16-39-31(27(23)13-19)7-9-36(10-8-31)26-17-38-18-26/h1-4,13-14,22,24-26,29,34H,5-12,16-18H2,(H,35,37)/t22-,24+,25-,29-/m0/s1 MIBKKDLVBYJWTB-AIKBEYBBSA-N 201012 US9540373, 1::US9879026, Example 1::USRE47636, Example 1 Dipeptidyl peptidase 1 1.10 25.00 C US Patent 10.7270/Q2NK3C6R aid1795079 US9540373 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201012&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118939917 375976336 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 480817 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2CCC3(CCNCC3)c2c1 InChI=1S/C29H33FN4O/c30-26-16-20(19-2-1-18-7-8-29(25(18)15-19)9-11-32-12-10-29)3-4-21(26)13-24(17-31)34-28(35)27-22-5-6-23(14-22)33-27/h1-4,15-16,22-24,27,32-33H,5-14H2,(H,34,35)/t22-,23+,24-,27-/m0/s1 DSRUXRRIDSZAIA-LAOBSVPGSA-N 201013 US9540373, 2::US9879026, Example 2::USRE47636, Example 2 Dipeptidyl peptidase 1 0.600 25.00 C US Patent 10.7270/Q2NK3C6R aid1795079 US9540373 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201013&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184937 375976337 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 523081 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2COC3(CCN(CC3)C3COC3)c2c1 InChI=1S/C31H35FN4O3/c32-28-14-20(1-3-21(28)11-25(15-33)35-30(37)29-22-5-6-24(12-22)34-29)19-2-4-23-16-39-31(27(23)13-19)7-9-36(10-8-31)26-17-38-18-26/h1-4,13-14,22,24-26,29,34H,5-12,16-18H2,(H,35,37)/t22-,24+,25-,29-/m0/s1 MIBKKDLVBYJWTB-AIKBEYBBSA-N 201012 US9540373, 1::US9879026, Example 1::USRE47636, Example 1 Dipeptidyl peptidase 1 1.10 25.00 C US Patent 10.7270/Q2K0768M aid1795496 US9879026 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201012&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118939917 375976336 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 523082 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2CCC3(CCNCC3)c2c1 InChI=1S/C29H33FN4O/c30-26-16-20(19-2-1-18-7-8-29(25(18)15-19)9-11-32-12-10-29)3-4-21(26)13-24(17-31)34-28(35)27-22-5-6-23(14-22)33-27/h1-4,15-16,22-24,27,32-33H,5-14H2,(H,34,35)/t22-,23+,24-,27-/m0/s1 DSRUXRRIDSZAIA-LAOBSVPGSA-N 201013 US9540373, 2::US9879026, Example 2::USRE47636, Example 2 Dipeptidyl peptidase 1 0.600 25.00 C US Patent 10.7270/Q2K0768M aid1795496 US9879026 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201013&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184937 375976337 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 523083 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2NC(=O)C3(CCNCC3)c2c1 InChI=1S/C28H30FN5O2/c29-23-14-17(16-4-6-24-22(13-16)28(27(36)34-24)7-9-31-10-8-28)1-2-18(23)11-21(15-30)33-26(35)25-19-3-5-20(12-19)32-25/h1-2,4,6,13-14,19-21,25,31-32H,3,5,7-12H2,(H,33,35)(H,34,36)/t19-,20+,21-,25-/m0/s1 WZYGEAFXJAOMCC-PDFGSZSQSA-N 201014 US9540373, 3::US9879026, Example 3::USRE47636, Example 3 Dipeptidyl peptidase 1 0.300 25.00 C US Patent 10.7270/Q2K0768M aid1795496 US9879026 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201014 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201014&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184938 375976338 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 523084 CN1C(=O)C2(CCNCC2)c2cc(ccc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C29H32FN5O2/c1-35-25-7-5-17(14-23(25)29(28(35)37)8-10-32-11-9-29)18-2-3-19(24(30)15-18)12-22(16-31)34-27(36)26-20-4-6-21(13-20)33-26/h2-3,5,7,14-15,20-22,26,32-33H,4,6,8-13H2,1H3,(H,34,36)/t20-,21+,22-,26-/m0/s1 CXEHWKQDWKZLQY-MSZDEVHKSA-N 201015 US9540373, 4::US9879026, Example 4::USRE47636, Example 4 Dipeptidyl peptidase 1 0.400 25.00 C US Patent 10.7270/Q2K0768M aid1795496 US9879026 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201015 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201015&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184939 375976339 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 523085 CN1C(=O)C2(CCN(C)CC2)c2cc(ccc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C30H34FN5O2/c1-35-11-9-30(10-12-35)24-15-18(6-8-26(24)36(2)29(30)38)19-3-4-20(25(31)16-19)13-23(17-32)34-28(37)27-21-5-7-22(14-21)33-27/h3-4,6,8,15-16,21-23,27,33H,5,7,9-14H2,1-2H3,(H,34,37)/t21-,22+,23-,27-/m0/s1 NFSMBZKEGKVOOI-GIRPNKPCSA-N 201016 US9540373, 5::US9879026, Example 5::USRE47636, Example 5 Dipeptidyl peptidase 1 0.600 25.00 C US Patent 10.7270/Q2K0768M aid1795496 US9879026 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201016&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184904 375976340 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 523086 CN1CCC2(CC1)C(=O)Nc1ccc(cc21)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C29H32FN5O2/c1-35-10-8-29(9-11-35)23-14-17(5-7-25(23)34-28(29)37)18-2-3-19(24(30)15-18)12-22(16-31)33-27(36)26-20-4-6-21(13-20)32-26/h2-3,5,7,14-15,20-22,26,32H,4,6,8-13H2,1H3,(H,33,36)(H,34,37)/t20-,21+,22-,26-/m0/s1 GANYKEOVXMYLES-MSZDEVHKSA-N 201017 US9540373, 6::US9879026, Example 6::USRE47636, Example 6 Dipeptidyl peptidase 1 0.200 25.00 C US Patent 10.7270/Q2K0768M aid1795496 US9879026 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201017&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184954 375976341 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 523087 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2C(=O)OC3(CCNCC3)c2c1 InChI=1S/C28H29FN4O3/c29-24-14-17(16-4-6-22-23(13-16)28(36-27(22)35)7-9-31-10-8-28)1-2-18(24)11-21(15-30)33-26(34)25-19-3-5-20(12-19)32-25/h1-2,4,6,13-14,19-21,25,31-32H,3,5,7-12H2,(H,33,34)/t19-,20+,21-,25-/m0/s1 ANLWAHOMUCKFHK-PDFGSZSQSA-N 201018 US9540373, 7::US9879026, Example 7::USRE47636, Example 7 Dipeptidyl peptidase 1 0.500 25.00 C US Patent 10.7270/Q2K0768M aid1795496 US9879026 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201018&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184955 375976342 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 523088 CN1CCC2(CC1)OC(=O)c1ccc(cc21)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C29H31FN4O3/c1-34-10-8-29(9-11-34)24-14-17(5-7-23(24)28(36)37-29)18-2-3-19(25(30)15-18)12-22(16-31)33-27(35)26-20-4-6-21(13-20)32-26/h2-3,5,7,14-15,20-22,26,32H,4,6,8-13H2,1H3,(H,33,35)/t20-,21+,22-,26-/m0/s1 HDXINRXLBDJTBO-MSZDEVHKSA-N 201019 US9540373, 8::US9879026, Example 8::USRE47636, Example 8 Dipeptidyl peptidase 1 0.700 25.00 C US Patent 10.7270/Q2K0768M aid1795496 US9879026 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201019 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201019&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184918 375976343 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 523089 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2C(=O)OC3(CCNC3)c2c1 InChI=1S/C27H27FN4O3/c28-23-12-16(15-4-6-21-22(11-15)27(35-26(21)34)7-8-30-14-27)1-2-17(23)9-20(13-29)32-25(33)24-18-3-5-19(10-18)31-24/h1-2,4,6,11-12,18-20,24,30-31H,3,5,7-10,14H2,(H,32,33)/t18-,19+,20-,24-,27?/m0/s1 IHLOZXJKAUYWCS-YRMZYPIJSA-N 201020 US9540373, 9::US9879026, Example 9::USRE47636, Example 9 Dipeptidyl peptidase 1 0.500 25.00 C US Patent 10.7270/Q2K0768M aid1795496 US9879026 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201020 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201020&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184927 375976344 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 523090 CN1CCC2(C1)OC(=O)c1ccc(cc21)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C28H29FN4O3/c1-33-9-8-28(15-33)23-12-16(5-7-22(23)27(35)36-28)17-2-3-18(24(29)13-17)10-21(14-30)32-26(34)25-19-4-6-20(11-19)31-25/h2-3,5,7,12-13,19-21,25,31H,4,6,8-11,15H2,1H3,(H,32,34)/t19-,20+,21-,25-,28?/m0/s1 GZDIEAVBMSLAOW-WWOCRAFXSA-N 201021 US9540373, 10::US9879026, Example 10::USRE47636, Example 10 Dipeptidyl peptidase 1 0.600 25.00 C US Patent 10.7270/Q2K0768M aid1795496 US9879026 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201021 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201021&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184917 375976345 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 523091 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2C(=O)OC3(CNC3)c2c1 InChI=1S/C26H25FN4O3/c27-22-10-15(14-4-6-20-21(9-14)26(12-29-13-26)34-25(20)33)1-2-16(22)7-19(11-28)31-24(32)23-17-3-5-18(8-17)30-23/h1-2,4,6,9-10,17-19,23,29-30H,3,5,7-8,12-13H2,(H,31,32)/t17-,18+,19-,23-/m0/s1 RZHGTZMOHTZJBI-YWNPBTLJSA-N 201022 US9540373, 11::US9879026, Example 11::USRE47636, Example 11 Dipeptidyl peptidase 1 0.700 25.00 C US Patent 10.7270/Q2K0768M aid1795496 US9879026 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201022 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201022&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184947 375976346 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 523092 CN1CC2(C1)OC(=O)c1ccc(cc21)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C27H27FN4O3/c1-32-13-27(14-32)22-10-15(5-7-21(22)26(34)35-27)16-2-3-17(23(28)11-16)8-20(12-29)31-25(33)24-18-4-6-19(9-18)30-24/h2-3,5,7,10-11,18-20,24,30H,4,6,8-9,13-14H2,1H3,(H,31,33)/t18-,19+,20-,24-/m0/s1 GWAYSZALTIDBDU-VKDGWMQASA-N 201023 US9540373, 12::US9879026, Example 12::USRE47636, Example 12 Dipeptidyl peptidase 1 0.500 25.00 C US Patent 10.7270/Q2K0768M aid1795496 US9879026 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201023&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184916 375976347 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 523093 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2COC3(CCNCC3)c2c1 InChI=1S/C28H31FN4O2/c29-25-14-18(17-2-4-21-16-35-28(24(21)13-17)7-9-31-10-8-28)1-3-19(25)11-23(15-30)33-27(34)26-20-5-6-22(12-20)32-26/h1-4,13-14,20,22-23,26,31-32H,5-12,16H2,(H,33,34)/t20-,22+,23-,26-/m0/s1 NGCHHBUOUZQOFZ-VBZBYZBJSA-N 201024 US9540373, 13::US9879026, Example 13::USRE47636, Example 13 Dipeptidyl peptidase 1 0.600 25.00 C US Patent 10.7270/Q2K0768M aid1795496 US9879026 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201024 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201024&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184898 375976348 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 523094 CN1CCC2(CC1)OCc1ccc(cc21)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C29H33FN4O2/c1-34-10-8-29(9-11-34)25-14-18(3-5-22(25)17-36-29)19-2-4-20(26(30)15-19)12-24(16-31)33-28(35)27-21-6-7-23(13-21)32-27/h2-5,14-15,21,23-24,27,32H,6-13,17H2,1H3,(H,33,35)/t21-,23+,24-,27-/m0/s1 LINMSXGSIPWEDG-DQHZSEARSA-N 201025 US9540373, 14::US9879026, Example 14::USRE47636, Example 14 Dipeptidyl peptidase 1 1.000 25.00 C US Patent 10.7270/Q2K0768M aid1795496 US9879026 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201025&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184899 375976349 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 523095 CN1CCC2(CCc3ccc(cc23)-c2ccc(C[C@H](NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)c(F)c2)CC1 InChI=1S/C30H35FN4O/c1-35-12-10-30(11-13-35)9-8-19-2-3-20(16-26(19)30)21-4-5-22(27(31)17-21)14-25(18-32)34-29(36)28-23-6-7-24(15-23)33-28/h2-5,16-17,23-25,28,33H,6-15H2,1H3,(H,34,36)/t23-,24+,25-,28-/m0/s1 QPILZBCBUNFEJW-GIBNYFNHSA-N 201026 US9540373, 15::US9879026, Example 15::USRE47636, Example 15 Dipeptidyl peptidase 1 0.500 25.00 C US Patent 10.7270/Q2K0768M aid1795496 US9879026 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201026&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184929 375976350 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 523096 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2NC(=O)C3(CCNC3)c2c1 InChI=1S/C27H28FN5O2/c28-22-12-16(15-4-6-23-21(11-15)27(26(35)33-23)7-8-30-14-27)1-2-17(22)9-20(13-29)32-25(34)24-18-3-5-19(10-18)31-24/h1-2,4,6,11-12,18-20,24,30-31H,3,5,7-10,14H2,(H,32,34)(H,33,35)/t18-,19+,20-,24-,27?/m0/s1 PPKDQAGFRUNTKU-YRMZYPIJSA-N 201027 US9540373, 16::US9879026, Example 16::USRE47636, Example 16 Dipeptidyl peptidase 1 0.500 25.00 C US Patent 10.7270/Q2K0768M aid1795496 US9879026 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201027&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184903 375976351 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 523097 CN1C(=O)C2(CCCN(C)C2)c2cc(ccc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C30H34FN5O2/c1-35-11-3-10-30(17-35)24-14-18(7-9-26(24)36(2)29(30)38)19-4-5-20(25(31)15-19)12-23(16-32)34-28(37)27-21-6-8-22(13-21)33-27/h4-5,7,9,14-15,21-23,27,33H,3,6,8,10-13,17H2,1-2H3,(H,34,37)/t21-,22+,23-,27-,30?/m0/s1 AAOICSZNQCRTDO-UALQKFLNSA-N 201028 US9540373, 17::US9879026, Example 17::USRE47636, Example 17 Dipeptidyl peptidase 1 1.60 25.00 C US Patent 10.7270/Q2K0768M aid1795496 US9879026 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201028&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184914 375976352 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 523098 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cc2c(cn1)C(=O)OC21CCNCC1 InChI=1S/C27H28FN5O3/c28-22-11-16(23-12-21-20(14-31-23)26(35)36-27(21)5-7-30-8-6-27)2-1-15(22)9-19(13-29)33-25(34)24-17-3-4-18(10-17)32-24/h1-2,11-12,14,17-19,24,30,32H,3-10H2,(H,33,34)/t17-,18+,19-,24-/m0/s1 SXKJOBWBROQYHC-YDLHNXBPSA-N 201029 US9540373, 18::US9879026, Example 18::USRE47636, Example 18 Dipeptidyl peptidase 1 1.60 25.00 C US Patent 10.7270/Q2K0768M aid1795496 US9879026 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201029&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184930 375976353 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 523099 CN1CCC2(CC1)OC(=O)c1cnc(cc21)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C28H30FN5O3/c1-34-8-6-28(7-9-34)22-13-24(31-15-21(22)27(36)37-28)17-3-2-16(23(29)12-17)10-20(14-30)33-26(35)25-18-4-5-19(11-18)32-25/h2-3,12-13,15,18-20,25,32H,4-11H2,1H3,(H,33,35)/t18-,19+,20-,25-/m0/s1 CLQRHMRHSRFUBH-ZDQHKECQSA-N 201030 US9540373, 19::US9879026, Example 19::USRE47636, Example 19 Dipeptidyl peptidase 1 1.000 25.00 C US Patent 10.7270/Q2K0768M aid1795496 US9879026 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201030&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184900 375976354 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 523100 CN1CCC2(C1)OC(=O)c1cnc(cc21)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C27H28FN5O3/c1-33-7-6-27(14-33)21-11-23(30-13-20(21)26(35)36-27)16-3-2-15(22(28)10-16)8-19(12-29)32-25(34)24-17-4-5-18(9-17)31-24/h2-3,10-11,13,17-19,24,31H,4-9,14H2,1H3,(H,32,34)/t17-,18+,19-,24-,27?/m0/s1 YZPZXQUEXBVKKM-IKHSKEIOSA-N 201031 US9540373, 20::US9879026, Example 20::USRE47636, Example 20 Dipeptidyl peptidase 1 1.60 25.00 C US Patent 10.7270/Q2K0768M aid1795496 US9879026 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201031&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184901 375976355 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 523101 CN1CCC2(CC1)OC(=O)c1ncc(cc21)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C28H30FN5O3/c1-34-8-6-28(7-9-34)22-12-19(15-31-25(22)27(36)37-28)16-2-3-17(23(29)13-16)10-21(14-30)33-26(35)24-18-4-5-20(11-18)32-24/h2-3,12-13,15,18,20-21,24,32H,4-11H2,1H3,(H,33,35)/t18-,20+,21-,24-/m0/s1 LQCCOFQTUNRXCK-UQWVPHONSA-N 201032 US9540373, 21::US9879026, Example 21::USRE47636, Example 21 Dipeptidyl peptidase 1 1.40 25.00 C US Patent 10.7270/Q2K0768M aid1795496 US9879026 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201032&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184956 375976356 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 523102 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cc2c(cn1)C(=O)OC21CCN(CC1)C1COC1 InChI=1S/C30H32FN5O4/c31-25-11-18(2-1-17(25)9-21(13-32)35-28(37)27-19-3-4-20(10-19)34-27)26-12-24-23(14-33-26)29(38)40-30(24)5-7-36(8-6-30)22-15-39-16-22/h1-2,11-12,14,19-22,27,34H,3-10,15-16H2,(H,35,37)/t19-,20+,21-,27-/m0/s1 JMHULBQBHVSKRL-WFQVPWNOSA-N 201033 US9540373, 22::US9879026, Example 22::USRE47636, Example 22 Dipeptidyl peptidase 1 4.80 25.00 C US Patent 10.7270/Q2K0768M aid1795496 US9879026 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201033&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184902 375976357 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 523103 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cc2c(COC22CCN(CC2)C2COC2)cn1 InChI=1S/C30H34FN5O3/c31-26-11-19(2-1-18(26)9-23(13-32)35-29(37)28-20-3-4-22(10-20)34-28)27-12-25-21(14-33-27)15-39-30(25)5-7-36(8-6-30)24-16-38-17-24/h1-2,11-12,14,20,22-24,28,34H,3-10,15-17H2,(H,35,37)/t20-,22+,23-,28-/m0/s1 VIDWRXWIFCHQDH-HQGMYGGFSA-N 201034 US9540373, 23::US9879026, Example 23::USRE47636, Example 23 Dipeptidyl peptidase 1 5.00 25.00 C US Patent 10.7270/Q2K0768M aid1795496 US9879026 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201034&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118939920 375976358 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 523104 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2C(=O)OC3(CCN(CC3)C3COC3)c2n1 InChI=1S/C30H32FN5O4/c31-24-13-18(2-1-17(24)11-21(14-32)34-28(37)26-19-3-4-20(12-19)33-26)25-6-5-23-27(35-25)30(40-29(23)38)7-9-36(10-8-30)22-15-39-16-22/h1-2,5-6,13,19-22,26,33H,3-4,7-12,15-16H2,(H,34,37)/t19-,20+,21-,26-/m0/s1 QDEUYXRXWLXIES-LMMUWCHVSA-N 201036 US9540373, 24::US9879026, Example 24::USRE47636, Example 24 Dipeptidyl peptidase 1 2.70 25.00 C US Patent 10.7270/Q2K0768M aid1795496 US9879026 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201036&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184892 375976359 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 523105 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2COC3(CCN(CC3)C3COC3)c2n1 InChI=1S/C30H34FN5O3/c31-25-13-19(2-1-18(25)11-23(14-32)34-29(37)27-20-3-5-22(12-20)33-27)26-6-4-21-15-39-30(28(21)35-26)7-9-36(10-8-30)24-16-38-17-24/h1-2,4,6,13,20,22-24,27,33H,3,5,7-12,15-17H2,(H,34,37)/t20-,22+,23-,27-/m0/s1 DJEHFUIVWJPRCP-XUTUTRJZSA-N 201037 US9540373, 25::US9879026, Example 25::USRE47636, Example 25 Dipeptidyl peptidase 1 1.80 25.00 C US Patent 10.7270/Q2K0768M aid1795496 US9879026 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201037 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201037&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118939923 375976360 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 523106 CN1CCC2(CC1)OCc1cnc(cc21)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C28H32FN5O2/c1-34-8-6-28(7-9-34)23-13-25(31-15-20(23)16-36-28)18-3-2-17(24(29)12-18)10-22(14-30)33-27(35)26-19-4-5-21(11-19)32-26/h2-3,12-13,15,19,21-22,26,32H,4-11,16H2,1H3,(H,33,35)/t19-,21+,22-,26-/m0/s1 LPWVDJUWYBLVEL-IYCJUYGXSA-N 201549 US9540373, 26::US9879026, Example 26::USRE47636, Example 26 Dipeptidyl peptidase 1 2.00 25.00 C US Patent 10.7270/Q2K0768M aid1795496 US9879026 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201549 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201549&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118939916 375976361 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 523107 Fc1cc(ccc1C[C@H](NC(=O)C12CCC(CC1)CN2)C#N)-c1ccc2COC3(CCN(CC3)C3COC3)c2c1 InChI=1S/C32H37FN4O3/c33-29-15-23(1-3-24(29)13-26(16-34)36-30(38)31-7-5-21(6-8-31)17-35-31)22-2-4-25-18-40-32(28(25)14-22)9-11-37(12-10-32)27-19-39-20-27/h1-4,14-15,21,26-27,35H,5-13,17-20H2,(H,36,38)/t21?,26-,31?/m0/s1 VCBLPORJGXYQEJ-YVWBODOZSA-N 201550 US9540373, 27::US9879026, Example 27::USRE47636, Example 27 Dipeptidyl peptidase 1 2.90 25.00 C US Patent 10.7270/Q2K0768M aid1795496 US9879026 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201550 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201550&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118939927 375976362 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 682559 OC(=O)C1CCN(CC1)C(=O)CN1CCC(CC1)Nc1ccc(Oc2ccc(cc2)-c2ncco2)cc1 InChI=1S/C28H32N4O5/c33-26(32-16-9-21(10-17-32)28(34)35)19-31-14-11-23(12-15-31)30-22-3-7-25(8-4-22)37-24-5-1-20(2-6-24)27-29-13-18-36-27/h1-8,13,18,21,23,30H,9-12,14-17,19H2,(H,34,35) RYOBYDLUILCXPC-UHFFFAOYSA-N 345818 US10202362, Compound T2.1 Dipeptidyl peptidase 1 7.10 US Patent 10.7270/Q2MC9241 aid1797290 US10202362 Roinestad, K; Guilford, W; Kirkland, T; Bhatt, L; Springman, E Celtaxsys, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345818 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345818&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 134587748 385451879 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 682561 OC(=O)c1ccc(CN2CCCC(CNc3ccc(Oc4ccc(Cl)cc4)cc3)C2)cc1 InChI=1S/C26H27ClN2O3/c27-22-7-11-24(12-8-22)32-25-13-9-23(10-14-25)28-16-20-2-1-15-29(18-20)17-19-3-5-21(6-4-19)26(30)31/h3-14,20,28H,1-2,15-18H2,(H,30,31) ZFTSPYMTXLAPOD-UHFFFAOYSA-N 345819 US10202362, Compound T2.2 Dipeptidyl peptidase 1 22.0 US Patent 10.7270/Q2MC9241 aid1797290 US10202362 Roinestad, K; Guilford, W; Kirkland, T; Bhatt, L; Springman, E Celtaxsys, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345819&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 134587745 385451880 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732407 CN1CCN(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H28FN5O/c1-26-6-8-27(9-7-26)18-5-3-14(19(22)12-18)10-17(13-23)25-21(28)20-15-2-4-16(11-15)24-20/h3,5,12,15-17,20,24H,2,4,6-11H2,1H3,(H,25,28)/t15-,16+,17-,20-/m0/s1 ZECDJSBLEVMTSQ-CLWJZODNSA-N 150332 US10238633, Example 6::US8987249, 6::US9713606, 6 Dipeptidyl peptidase 1 10.7 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150332 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150332&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90413749 252824583 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732408 CC(=O)n1nc(cc1C)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H24FN5O2/c1-12-7-20(27-28(12)13(2)29)15-4-3-14(19(23)10-15)8-18(11-24)26-22(30)21-16-5-6-17(9-16)25-21/h3-4,7,10,16-18,21,25H,5-6,8-9H2,1-2H3,(H,26,30)/t16-,17+,18?,21-/m0/s1 LZLTXNWOZBVHCY-APZTZJSISA-N 150333 US10238633, Example 7::US8987249, 7::US9713606, 7 Dipeptidyl peptidase 1 1.90 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150333 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150333&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90413606 252824584 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732409 O=C(NC(Cc1ccc2[nH]ncc2c1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 150334 US10238633, Example 8::US8987249, 8::US9713606, 8 Dipeptidyl peptidase 1 679 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150334&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90415654 252824585 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732410 O=C(NC(Cc1ccc2c3ccccc3[nH]c(=O)c2c1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 150335 US10238633, Example 9::US8987249, 9::US9713606, 9 Dipeptidyl peptidase 1 9.60 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150335 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150335&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937188 252824586 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732411 CN1C(=O)C(=O)c2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C25H23FN4O3/c1-30-21-11-14(5-7-19(21)23(31)25(30)33)13-2-3-15(20(26)10-13)8-18(12-27)29-24(32)22-16-4-6-17(9-16)28-22/h2-3,5,7,10-11,16-18,22,28H,4,6,8-9H2,1H3,(H,29,32)/t16-,17+,18-,22-/m0/s1 MQKJSVBPRAMRJU-SUWCGCSTSA-N 150336 US10238633, Example 10::US8987249, 10::US9713606, 10 Dipeptidyl peptidase 1 1.50 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150336&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443233 252824587 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732412 Fc1cc(ccc1CC(NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2C(=O)OCc2c1 InChI=1S/C24H22FN3O3/c25-21-10-14(13-4-6-20-17(7-13)12-31-24(20)30)1-2-15(21)8-19(11-26)28-23(29)22-16-3-5-18(9-16)27-22/h1-2,4,6-7,10,16,18-19,22,27H,3,5,8-9,12H2,(H,28,29)/t16-,18+,19?,22-/m0/s1 WTHQKFUPVXDWIU-AAEOLZRXSA-N 150337 US10238633, Example 11::US8987249, 11::US9713606, 11 Dipeptidyl peptidase 1 1.70 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150337 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150337&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430788 252824588 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732413 CS(=O)(=O)c1ccc(cc1F)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H23F2N3O3S/c1-32(30,31)21-7-5-14(11-20(21)25)13-2-3-15(19(24)10-13)8-18(12-26)28-23(29)22-16-4-6-17(9-16)27-22/h2-3,5,7,10-11,16-18,22,27H,4,6,8-9H2,1H3,(H,28,29)/t16-,17+,18-,22-/m0/s1 ZGJRMKDBJBZGHJ-SUWCGCSTSA-N 150338 US10238633, Example 12::US8987249, 12::US9713606, 12 Dipeptidyl peptidase 1 1.90 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150338 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150338&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430789 252824589 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732414 COC(=O)Cn1cc(cn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H24FN5O3/c1-31-20(29)12-28-11-16(10-25-28)13-2-3-14(19(23)8-13)6-18(9-24)27-22(30)21-15-4-5-17(7-15)26-21/h2-3,8,10-11,15,17-18,21,26H,4-7,12H2,1H3,(H,27,30)/t15-,17+,18-,21-/m0/s1 NHUZJCGXGLXXCK-DKXUYOFUSA-N 150339 US10238633, Example 13::US8987249, 13::US9713606, 13 Dipeptidyl peptidase 1 1.90 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150339 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150339&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430783 252824590 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732415 CS(=O)(=O)c1cc(ccc1C#N)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H23FN4O3S/c1-33(31,32)22-11-15(3-5-18(22)12-26)14-2-4-16(21(25)10-14)8-20(13-27)29-24(30)23-17-6-7-19(9-17)28-23/h2-5,10-11,17,19-20,23,28H,6-9H2,1H3,(H,29,30)/t17-,19+,20-,23-/m0/s1 AUHJWFLPELHPMB-USKVXJDGSA-N 150340 US10238633, Example 14::US8987249, 14::US9713606, 14 Dipeptidyl peptidase 1 2.00 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150340&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443035 252824591 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732416 CN1C(=O)Cc2ccc(cc12)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C25H25FN4O2/c1-30-22-11-15(3-5-17(22)12-23(30)31)14-2-4-16(21(26)10-14)8-20(13-27)29-25(32)24-18-6-7-19(9-18)28-24/h2-5,10-11,18-20,24,28H,6-9,12H2,1H3,(H,29,32)/t18-,19+,20?,24-/m0/s1 MNEOBAAFLAQMKF-BQTZMPSMSA-N 150341 US10238633, Example 15::US8987249, 15::US9713606, 15 Dipeptidyl peptidase 1 2.00 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150341 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150341&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430760 252824592 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732417 CS(=O)(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H24FN3O3S/c1-31(29,30)20-8-5-14(6-9-20)15-2-3-16(21(24)12-15)10-19(13-25)27-23(28)22-17-4-7-18(11-17)26-22/h2-3,5-6,8-9,12,17-19,22,26H,4,7,10-11H2,1H3,(H,27,28)/t17-,18+,19-,22-/m0/s1 KKCIOVAGWAIFAX-WEMPKCCASA-N 150342 US10238633, Example 16::US8987249, 16::US9713606, 16 Dipeptidyl peptidase 1 2.60 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150342 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150342&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430804 252824593 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732418 COC(=O)c1cc(cs1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H22FN3O3S/c1-29-22(28)19-9-15(11-30-19)12-2-3-13(18(23)8-12)6-17(10-24)26-21(27)20-14-4-5-16(7-14)25-20/h2-3,8-9,11,14,16-17,20,25H,4-7H2,1H3,(H,26,27)/t14-,16+,17-,20-/m0/s1 QSEMIFYIVMRBGQ-FORWCCJISA-N 150343 US10238633, Example 17::US8987249, 17::US9713606, 17 Dipeptidyl peptidase 1 2.60 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150343 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150343&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430761 252824594 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732419 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccsc1 InChI=1S/C20H20FN3OS/c21-18-9-12(15-5-6-26-11-15)1-2-13(18)7-17(10-22)24-20(25)19-14-3-4-16(8-14)23-19/h1-2,5-6,9,11,14,16-17,19,23H,3-4,7-8H2,(H,24,25)/t14-,16+,17-,19-/m0/s1 CUGBXLAZKQOEHU-RUENVJTFSA-N 150344 US10238633, Example 18::US8987249, 18::US9713606, 18 Dipeptidyl peptidase 1 2.70 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150344 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150344&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430762 252824595 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732420 CS(=O)(=O)c1cc(ccc1C#N)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H23FN4O3S/c1-33(31,32)22-11-15(3-5-18(22)12-26)14-2-4-16(21(25)10-14)8-20(13-27)29-24(30)23-17-6-7-19(9-17)28-23/h2-5,10-11,17,19-20,23,28H,6-9H2,1H3,(H,29,30)/t17-,19+,20?,23-/m0/s1 AUHJWFLPELHPMB-GKUGZCSRSA-N 150345 US10238633, Example 19::US8987249, 19::US9713606, 19 Dipeptidyl peptidase 1 2.80 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150345&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443252 252824596 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732421 CC(=O)n1cc(cn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H22FN5O2/c1-12(28)27-11-16(10-24-27)13-2-3-14(19(22)8-13)6-18(9-23)26-21(29)20-15-4-5-17(7-15)25-20/h2-3,8,10-11,15,17-18,20,25H,4-7H2,1H3,(H,26,29)/t15-,17+,18-,20-/m0/s1 YGHKDCMFTPEJME-NFBUACBFSA-N 150346 US10238633, Example 20::US8987249, 20::US9713606, 20 Dipeptidyl peptidase 1 3.10 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150346 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150346&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443158 252824597 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732422 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnn(CC2CCOC2)c1 InChI=1S/C24H28FN5O2/c25-22-9-16(19-11-27-30(13-19)12-15-5-6-32-14-15)1-2-17(22)7-21(10-26)29-24(31)23-18-3-4-20(8-18)28-23/h1-2,9,11,13,15,18,20-21,23,28H,3-8,12,14H2,(H,29,31)/t15?,18-,20+,21-,23-/m0/s1 CWXBPKJABGXNSH-ZDOHZWEYSA-N 150347 US10238633, Example 21::US8987249, 21::US9713606, 21 Dipeptidyl peptidase 1 3.10 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150347 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150347&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430561 252824598 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732423 Fc1cc(ccc1CC(NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2CC(=O)Nc2c1 InChI=1S/C24H23FN4O2/c25-20-9-13(14-2-4-16-11-22(30)29-21(16)10-14)1-3-15(20)7-19(12-26)28-24(31)23-17-5-6-18(8-17)27-23/h1-4,9-10,17-19,23,27H,5-8,11H2,(H,28,31)(H,29,30)/t17-,18+,19?,23-/m0/s1 GRTBTBDXCOSHDK-UNEJAWRNSA-N 150348 US10238633, Example 22::US8987249, 22::US9713606, 22 Dipeptidyl peptidase 1 3.30 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150348 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150348&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430555 252824599 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732424 CC(C)(C)n1cc(cn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H28FN5O/c1-23(2,3)29-13-17(12-26-29)14-4-5-15(20(24)10-14)8-19(11-25)28-22(30)21-16-6-7-18(9-16)27-21/h4-5,10,12-13,16,18-19,21,27H,6-9H2,1-3H3,(H,28,30)/t16-,18+,19-,21-/m0/s1 HVHUNYHQWGGPMT-KRQVXIAISA-N 150349 US10238633, Example 23::US8987249, 23::US9713606, 23 Dipeptidyl peptidase 1 3.70 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150349 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150349&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430551 252824600 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732425 CN1C(=O)Cc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1F InChI=1S/C25H24F2N4O2/c1-31-20-10-13(2-3-14(20)11-21(31)32)19-7-5-15(22(26)23(19)27)8-18(12-28)30-25(33)24-16-4-6-17(9-16)29-24/h2-3,5,7,10,16-18,24,29H,4,6,8-9,11H2,1H3,(H,30,33)/t16-,17+,18-,24-/m0/s1 LJUVJDUKKVZRFZ-AIDSWVIKSA-N 150350 US10238633, Example 24::US8987249, 24::US9713606, 24 Dipeptidyl peptidase 1 3.70 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150350 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150350&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430553 252824601 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732426 Cc1ncc(s1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C20H21FN4OS/c1-11-23-10-18(27-11)13-3-2-12(17(21)8-13)6-16(9-22)25-20(26)19-14-4-5-15(7-14)24-19/h2-3,8,10,14-16,19,24H,4-7H2,1H3,(H,25,26)/t14-,15+,16-,19-/m0/s1 SKTGXDCDCGNQOW-RCJHGTSTSA-N 150351 US10238633, Example 25::US8987249, 25::US9713606, 25 Dipeptidyl peptidase 1 3.90 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150351&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430587 252824602 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732427 CCn1cc(cn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H24FN5O/c1-2-27-12-16(11-24-27)13-3-4-14(19(22)9-13)7-18(10-23)26-21(28)20-15-5-6-17(8-15)25-20/h3-4,9,11-12,15,17-18,20,25H,2,5-8H2,1H3,(H,26,28)/t15-,17+,18-,20-/m0/s1 BOEDWXHZEWDSOJ-NFBUACBFSA-N 150352 US10238633, Example 26::US8987249, 26::US9713606, 26 Dipeptidyl peptidase 1 4.00 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150352 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150352&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430578 252824603 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732428 Cc1ccc(o1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H22FN3O2/c1-12-2-7-19(27-12)14-4-3-13(18(22)10-14)8-17(11-23)25-21(26)20-15-5-6-16(9-15)24-20/h2-4,7,10,15-17,20,24H,5-6,8-9H2,1H3,(H,25,26)/t15-,16+,17-,20-/m0/s1 WPUSIXGXCBPYHG-CLWJZODNSA-N 150353 US10238633, Example 27::US8987249, 27::US9713606, 27 Dipeptidyl peptidase 1 4.00 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150353 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150353&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430579 252824604 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732429 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnn(CC2CCCCO2)c1 InChI=1S/C25H30FN5O2/c26-23-11-16(19-13-28-31(14-19)15-22-3-1-2-8-33-22)4-5-17(23)9-21(12-27)30-25(32)24-18-6-7-20(10-18)29-24/h4-5,11,13-14,18,20-22,24,29H,1-3,6-10,15H2,(H,30,32)/t18-,20+,21-,22?,24-/m0/s1 SLLIUCDDDQLBAQ-MVUGTHIMSA-N 150354 US10238633, Example 28::US8987249, 28::US9713606, 28 Dipeptidyl peptidase 1 4.10 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150354 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150354&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430571 252824605 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732430 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2CC(=O)Nc2c1 InChI=1S/C24H23FN4O2/c25-20-9-13(14-2-4-16-11-22(30)29-21(16)10-14)1-3-15(20)7-19(12-26)28-24(31)23-17-5-6-18(8-17)27-23/h1-4,9-10,17-19,23,27H,5-8,11H2,(H,28,31)(H,29,30)/t17-,18+,19-,23-/m0/s1 GRTBTBDXCOSHDK-YWNPBTLJSA-N 150355 US10238633, Example 29::US8987249, 29::US9713606, 29 Dipeptidyl peptidase 1 4.20 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150355&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430677 252824606 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732431 CCCn1cc(cn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H26FN5O/c1-2-7-28-13-17(12-25-28)14-3-4-15(20(23)10-14)8-19(11-24)27-22(29)21-16-5-6-18(9-16)26-21/h3-4,10,12-13,16,18-19,21,26H,2,5-9H2,1H3,(H,27,29)/t16-,18+,19-,21-/m0/s1 LCAYDHNDEUNJEG-KRQVXIAISA-N 150356 US10238633, Example 30::US8987249, 30::US9713606, 30 Dipeptidyl peptidase 1 4.20 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150356 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150356&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430567 252824607 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732432 CN1C(=O)Cc2ccc(cc12)-c1cc(F)c(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1F InChI=1S/C25H24F2N4O2/c1-31-22-9-13(2-3-14(22)10-23(31)32)19-11-20(26)16(8-21(19)27)7-18(12-28)30-25(33)24-15-4-5-17(6-15)29-24/h2-3,8-9,11,15,17-18,24,29H,4-7,10H2,1H3,(H,30,33)/t15-,17+,18?,24-/m0/s1 JXOWBXXJEMLQAI-GUZYLCRVSA-N 150357 US10238633, Example 31::US8987249, 31 Dipeptidyl peptidase 1 4.30 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150357 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150357&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430305 252824608 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732433 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCN(CC1)c1ccccc1 InChI=1S/C26H30FN5O/c27-24-16-23(32-12-10-31(11-13-32)22-4-2-1-3-5-22)9-7-18(24)14-21(17-28)30-26(33)25-19-6-8-20(15-19)29-25/h1-5,7,9,16,19-21,25,29H,6,8,10-15H2,(H,30,33)/t19-,20+,21-,25-/m0/s1 FPIYYDMSEAXZFH-PDFGSZSQSA-N 150358 US10238633, Example 32::US8987249, 32::US9713606, 32 Dipeptidyl peptidase 1 4.50 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150358&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90415523 252824609 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732434 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc(s1)C(F)(F)F InChI=1S/C21H19F4N3OS/c22-16-9-12(17-5-6-18(30-17)21(23,24)25)2-1-11(16)7-15(10-26)28-20(29)19-13-3-4-14(8-13)27-19/h1-2,5-6,9,13-15,19,27H,3-4,7-8H2,(H,28,29)/t13-,14+,15-,19-/m0/s1 HRFVYBFWQMQWTD-YGTYGHESSA-N 150359 US10238633, Example 33::US8987249, 33::US9713606, 33 Dipeptidyl peptidase 1 4.50 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150359 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150359&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430300 252824610 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732435 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2COC(=O)c2c1 InChI=1S/C24H22FN3O3/c25-21-10-14(13-2-4-17-12-31-24(30)20(17)9-13)1-3-15(21)7-19(11-26)28-23(29)22-16-5-6-18(8-16)27-22/h1-4,9-10,16,18-19,22,27H,5-8,12H2,(H,28,29)/t16-,18+,19-,22-/m0/s1 IHMLKNVVWQAOBN-ZBPHCFQXSA-N 150360 US10238633, Example 34::US8987249, 34::US9713606, 34 Dipeptidyl peptidase 1 4.60 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150360 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150360&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430302 252824611 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732436 Fc1cc(ccc1CC(NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc(C#N)c(F)c1 InChI=1S/C23H20F2N4O/c24-20-9-13(14-2-4-17(11-26)21(25)10-14)1-3-15(20)7-19(12-27)29-23(30)22-16-5-6-18(8-16)28-22/h1-4,9-10,16,18-19,22,28H,5-8H2,(H,29,30)/t16-,18+,19?,22-/m0/s1 ZACSQEJERMQYBO-AAEOLZRXSA-N 150361 US10238633, Example 35::US8987249, 35::US9713606, 35 Dipeptidyl peptidase 1 4.60 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150361 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150361&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430303 252824612 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732437 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cccs1 InChI=1S/C20H20FN3OS/c21-17-10-13(18-2-1-7-26-18)4-3-12(17)8-16(11-22)24-20(25)19-14-5-6-15(9-14)23-19/h1-4,7,10,14-16,19,23H,5-6,8-9H2,(H,24,25)/t14-,15+,16-,19-/m0/s1 XFLYDHSZANAGSB-RCJHGTSTSA-N 150362 US10238633, Example 36::US8987249, 36::US9713606, 36 Dipeptidyl peptidase 1 4.70 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150362&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430301 252824613 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732438 NS(=O)(=O)c1cccc(c1)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H23FN4O3S/c23-20-11-14(13-2-1-3-19(10-13)31(25,29)30)4-5-15(20)8-18(12-24)27-22(28)21-16-6-7-17(9-16)26-21/h1-5,10-11,16-18,21,26H,6-9H2,(H,27,28)(H2,25,29,30)/t16-,17+,18?,21-/m0/s1 YOUYIXZXGRAFJC-APZTZJSISA-N 150363 US10238633, Example 37::US8987249, 37 Dipeptidyl peptidase 1 4.70 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150363 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150363&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430855 252824614 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732439 CC(=O)NCCn1cc(cn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H27FN6O2/c1-14(31)26-6-7-30-13-18(12-27-30)15-2-3-16(21(24)10-15)8-20(11-25)29-23(32)22-17-4-5-19(9-17)28-22/h2-3,10,12-13,17,19-20,22,28H,4-9H2,1H3,(H,26,31)(H,29,32)/t17-,19+,20-,22-/m0/s1 AZUWHWHOUQWSGG-UFGBVDADSA-N 150364 US10238633, Example 38::US8987249, 38::US9713606, 38 Dipeptidyl peptidase 1 4.80 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150364 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150364&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937189 252824615 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732440 Cc1c(cnn1C)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H24FN5O/c1-12-18(11-24-27(12)2)13-3-4-14(19(22)9-13)7-17(10-23)26-21(28)20-15-5-6-16(8-15)25-20/h3-4,9,11,15-17,20,25H,5-8H2,1-2H3,(H,26,28)/t15-,16+,17-,20-/m0/s1 BXMGRZWIJVZYAS-CLWJZODNSA-N 150365 US10238633, Example 39::US8987249, 39::US9713606, 65 Dipeptidyl peptidase 1 5.10 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150365 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150365&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430769 252824616 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732441 Fc1cc(ccc1C[C@@H](C#N)C(=O)[C@H]1N[C@H]2C[C@@H]1[C@@H]1C[C@H]21)-c1ccc(s1)C#N InChI=1S/C22H18FN3OS/c23-18-6-12(20-4-3-14(10-25)28-20)2-1-11(18)5-13(9-24)22(27)21-17-8-19(26-21)16-7-15(16)17/h1-4,6,13,15-17,19,21,26H,5,7-8H2/t13-,15+,16-,17+,19-,21-/m0/s1 WRRZKUPVQIFUHI-ARFSGQLGSA-N 370611 US10238633, Example 40 Dipeptidyl peptidase 1 5.10 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370611 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370611&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 130433651 402357593 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732442 Fc1cc(ccc1CC(NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2C(=O)NCc2c1 InChI=1S/C24H23FN4O2/c25-21-10-14(13-4-6-20-17(7-13)12-27-23(20)30)1-2-15(21)8-19(11-26)29-24(31)22-16-3-5-18(9-16)28-22/h1-2,4,6-7,10,16,18-19,22,28H,3,5,8-9,12H2,(H,27,30)(H,29,31)/t16-,18+,19?,22-/m0/s1 AUFRBRNWPXRXNC-AAEOLZRXSA-N 150367 US10238633, Example 41::US8987249, 41::US9713606, 41 Dipeptidyl peptidase 1 5.30 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150367 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150367&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430724 252824618 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732443 CN1CCc2cc(ccc2C1=O)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C26H27FN4O2/c1-31-9-8-17-10-15(5-7-22(17)26(31)33)16-2-3-18(23(27)13-16)11-21(14-28)30-25(32)24-19-4-6-20(12-19)29-24/h2-3,5,7,10,13,19-21,24,29H,4,6,8-9,11-12H2,1H3,(H,30,32)/t19-,20+,21-,24-/m0/s1 XZKCAVQABJPIBE-XARGGIHNSA-N 150368 US10238633, Example 42::US8987249, 42::US9713606, 42 Dipeptidyl peptidase 1 5.30 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150368 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150368&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430764 252824619 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732444 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCN2CCOCC2C1 InChI=1S/C23H30FN5O2/c24-21-11-19(29-6-5-28-7-8-31-14-20(28)13-29)4-2-15(21)9-18(12-25)27-23(30)22-16-1-3-17(10-16)26-22/h2,4,11,16-18,20,22,26H,1,3,5-10,13-14H2,(H,27,30)/t16-,17+,18-,20?,22-/m0/s1 SOLOVPGTCODBHF-AEJWZEPGSA-N 150369 US10238633, Example 43::US8987249, 43::US9713606, 43 Dipeptidyl peptidase 1 5.60 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150369 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150369&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430331 252824620 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732445 COCCn1cc(cn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H26FN5O2/c1-30-7-6-28-13-17(12-25-28)14-2-3-15(20(23)10-14)8-19(11-24)27-22(29)21-16-4-5-18(9-16)26-21/h2-3,10,12-13,16,18-19,21,26H,4-9H2,1H3,(H,27,29)/t16-,18+,19-,21-/m0/s1 IQMJMZXJSJWJBP-KRQVXIAISA-N 150370 US10238633, Example 44::US8987249, 44::US9713606, 44 Dipeptidyl peptidase 1 5.90 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150370 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150370&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443235 252824621 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732446 Fc1cc(ccc1C[C@@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2ncsc2c1 InChI=1S/C23H21FN4OS/c24-19-9-13(14-4-6-20-21(10-14)30-12-26-20)1-2-15(19)7-18(11-25)28-23(29)22-16-3-5-17(8-16)27-22/h1-2,4,6,9-10,12,16-18,22,27H,3,5,7-8H2,(H,28,29)/t16-,17+,18+,22-/m0/s1 MAGRORJEPPDWJZ-FBAVSBLXSA-N 150371 US10238633, Example 45::US8987249, 45::US9713606, 45 Dipeptidyl peptidase 1 6.30 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150371 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150371&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430332 252824622 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732447 CCc1ncc(s1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H23FN4OS/c1-2-19-24-11-18(28-19)13-4-3-12(17(22)9-13)7-16(10-23)26-21(27)20-14-5-6-15(8-14)25-20/h3-4,9,11,14-16,20,25H,2,5-8H2,1H3,(H,26,27)/t14-,15+,16-,20-/m0/s1 UQUJAZLXHZCONU-QOIOWGMHSA-N 150372 US10238633, Example 46::US8987249, 46 Dipeptidyl peptidase 1 6.90 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150372 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150372&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430379 252824623 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732448 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-n1cc(COc2ccccc2)nn1 InChI=1S/C25H25FN6O2/c26-23-12-21(32-14-20(30-31-32)15-34-22-4-2-1-3-5-22)9-7-16(23)10-19(13-27)29-25(33)24-17-6-8-18(11-17)28-24/h1-5,7,9,12,14,17-19,24,28H,6,8,10-11,15H2,(H,29,33)/t17-,18+,19-,24-/m0/s1 YQMDZGGJGGSBDR-YDLHNXBPSA-N 150373 US10238633, Example 47::US8987249, 47::US9713606, 47 Dipeptidyl peptidase 1 7.20 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150373 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150373&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90440137 252824624 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732449 CC(C)CC(=O)n1cc(cn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H28FN5O2/c1-14(2)7-22(31)30-13-18(12-27-30)15-3-4-16(21(25)10-15)8-20(11-26)29-24(32)23-17-5-6-19(9-17)28-23/h3-4,10,12-14,17,19-20,23,28H,5-9H2,1-2H3,(H,29,32)/t17-,19+,20-,23-/m0/s1 HRUNAKRSSYTYRA-USKVXJDGSA-N 150374 US10238633, Example 48::US8987249, 48::US9713606, 48 Dipeptidyl peptidase 1 7.20 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150374 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150374&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443268 252824625 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732450 Fc1cc(ccc1CC(NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2C(=O)NCCc2c1 InChI=1S/C25H25FN4O2/c26-22-12-15(14-4-6-21-16(9-14)7-8-28-24(21)31)1-2-17(22)10-20(13-27)30-25(32)23-18-3-5-19(11-18)29-23/h1-2,4,6,9,12,18-20,23,29H,3,5,7-8,10-11H2,(H,28,31)(H,30,32)/t18-,19+,20?,23-/m0/s1 GEDCUYAXKGCEAP-SRDOODBNSA-N 150375 US10238633, Example 49::US8987249, 49::US9713606, 49 Dipeptidyl peptidase 1 7.30 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150375 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150375&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430681 252824626 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732451 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnn(CC2CCCO2)c1 InChI=1S/C24H28FN5O2/c25-22-10-15(18-12-27-30(13-18)14-21-2-1-7-32-21)3-4-16(22)8-20(11-26)29-24(31)23-17-5-6-19(9-17)28-23/h3-4,10,12-13,17,19-21,23,28H,1-2,5-9,14H2,(H,29,31)/t17-,19+,20-,21?,23-/m0/s1 HMZMPMLDAMDPBI-XHISBUKVSA-N 150376 US10238633, Example 50::US8987249, 50::US9713606, 50 Dipeptidyl peptidase 1 7.40 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150376 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150376&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430682 252824627 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732452 CNS(=O)(=O)c1ccc(cc1)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H25FN4O3S/c1-26-32(30,31)20-8-5-14(6-9-20)15-2-3-16(21(24)12-15)10-19(13-25)28-23(29)22-17-4-7-18(11-17)27-22/h2-3,5-6,8-9,12,17-19,22,26-27H,4,7,10-11H2,1H3,(H,28,29)/t17-,18+,19?,22-/m0/s1 YCLHWAIRELKEQO-HJKBJPMPSA-N 150377 US10238633, Example 51::US8987249, 51::US9713606, 51 Dipeptidyl peptidase 1 7.50 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150377 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150377&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430653 252824628 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732453 CS(=O)(=O)c1cc(ccc1C#N)-c1cc(F)c(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H22F2N4O3S/c1-34(32,33)22-9-13(2-3-15(22)11-27)16-7-20(25)19(21(26)8-16)10-18(12-28)30-24(31)23-14-4-5-17(6-14)29-23/h2-3,7-9,14,17-18,23,29H,4-6,10H2,1H3,(H,30,31)/t14-,17+,18?,23-/m0/s1 APWWFYPMQQAZJM-JRRJEJKYSA-N 150378 US10238633, Example 52::US8987249, 52::US9713606, 52 Dipeptidyl peptidase 1 7.60 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150378 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150378&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430599 252824629 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732454 NC(=O)c1cccc(c1)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H23FN4O2/c24-20-11-14(13-2-1-3-17(8-13)22(26)29)4-5-15(20)9-19(12-25)28-23(30)21-16-6-7-18(10-16)27-21/h1-5,8,11,16,18-19,21,27H,6-7,9-10H2,(H2,26,29)(H,28,30)/t16-,18+,19?,21-/m0/s1 URKPBBPYGGQLCL-PLPRGGQXSA-N 150379 US10238633, Example 53::US8987249, 53::US9713606, 53 Dipeptidyl peptidase 1 7.90 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150379 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150379&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430609 252824630 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732455 CS(=O)(=O)c1ccc(cc1)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H24FN3O3S/c1-31(29,30)20-8-5-14(6-9-20)15-2-3-16(21(24)12-15)10-19(13-25)27-23(28)22-17-4-7-18(11-17)26-22/h2-3,5-6,8-9,12,17-19,22,26H,4,7,10-11H2,1H3,(H,27,28)/t17-,18+,19?,22-/m0/s1 KKCIOVAGWAIFAX-HJKBJPMPSA-N 150380 US10238633, Example 54::US8987249, 54::US9713606, 54 Dipeptidyl peptidase 1 8.20 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150380 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150380&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430765 252824631 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732456 CC(=O)N1CCC(Cn2cc(cn2)-c2ccc(C[C@H](NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)c(F)c2)CC1 InChI=1S/C27H33FN6O2/c1-17(35)33-8-6-18(7-9-33)15-34-16-22(14-30-34)19-2-3-20(25(28)12-19)10-24(13-29)32-27(36)26-21-4-5-23(11-21)31-26/h2-3,12,14,16,18,21,23-24,26,31H,4-11,15H2,1H3,(H,32,36)/t21-,23+,24-,26-/m0/s1 BIHZNSYCANDRTI-YUZJIJRXSA-N 150381 US10238633, Example 55::US8987249, 55::US9713606, 55 Dipeptidyl peptidase 1 8.20 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150381 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150381&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430715 252824632 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732457 NS(=O)(=O)c1ccc(cc1)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H23FN4O3S/c23-20-11-14(13-4-7-19(8-5-13)31(25,29)30)1-2-15(20)9-18(12-24)27-22(28)21-16-3-6-17(10-16)26-21/h1-2,4-5,7-8,11,16-18,21,26H,3,6,9-10H2,(H,27,28)(H2,25,29,30)/t16-,17+,18?,21-/m0/s1 JPKDSNDSOPINLH-APZTZJSISA-N 150382 US10238633, Example 56::US8987249, 56::US9713606, 56 Dipeptidyl peptidase 1 8.30 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150382 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150382&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430748 252824633 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732458 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnn(CC2CCOCC2)c1 InChI=1S/C25H30FN5O2/c26-23-11-17(20-13-28-31(15-20)14-16-5-7-33-8-6-16)1-2-18(23)9-22(12-27)30-25(32)24-19-3-4-21(10-19)29-24/h1-2,11,13,15-16,19,21-22,24,29H,3-10,14H2,(H,30,32)/t19-,21+,22-,24-/m0/s1 DONGIUVRNSCBKX-OHCHIEETSA-N 150383 US10238633, Example 57::US8987249, 57::US9713606, 57 Dipeptidyl peptidase 1 8.30 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150383 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150383&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430727 252824634 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732459 Cc1cc(n[nH]1)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 150384 US10238633, Example 58::US8987249, 58::US9713606, 58 Dipeptidyl peptidase 1 8.40 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150384 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150384&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430774 252824635 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732460 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnc(s1)N1CCOCC1 InChI=1S/C23H26FN5O2S/c24-19-11-15(20-13-26-23(32-20)29-5-7-31-8-6-29)2-1-14(19)9-18(12-25)28-22(30)21-16-3-4-17(10-16)27-21/h1-2,11,13,16-18,21,27H,3-10H2,(H,28,30)/t16-,17+,18-,21-/m0/s1 VBXNUQLHVDGVOH-NYUBLWNDSA-N 150385 US10238633, Example 59::US8987249, 59::US9713606, 59 Dipeptidyl peptidase 1 8.50 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150385 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150385&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430869 252824636 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732461 Cn1nc2ccccc2c1-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H24FN5O/c1-30-23(19-4-2-3-5-21(19)29-30)16-7-6-14(20(25)12-16)10-18(13-26)28-24(31)22-15-8-9-17(11-15)27-22/h2-7,12,15,17-18,22,27H,8-11H2,1H3,(H,28,31)/t15-,17+,18-,22-/m0/s1 JXCFAQSIBMJFEG-PBWVOLNLSA-N 150386 US10238633, Example 60::US8987249, 60::US9713606, 60 Dipeptidyl peptidase 1 8.70 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150386 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150386&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430799 252824637 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732462 CN1C(=O)Cc2ccc(cc12)-c1cc(F)c(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C25H24F2N4O2/c1-31-22-9-13(2-3-14(22)10-23(31)32)16-7-20(26)19(21(27)8-16)11-18(12-28)30-25(33)24-15-4-5-17(6-15)29-24/h2-3,7-9,15,17-18,24,29H,4-6,10-11H2,1H3,(H,30,33)/t15-,17+,18?,24-/m0/s1 YIKYGCSOAIKXDX-GUZYLCRVSA-N 150387 US10238633, Example 61::US8987249, 61::US9713606, 61 Dipeptidyl peptidase 1 8.70 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150387 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150387&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430800 252824638 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732463 CS(=O)(=O)Nc1ccc(cc1)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H25FN4O3S/c1-32(30,31)28-18-7-4-14(5-8-18)15-2-3-16(21(24)12-15)10-20(13-25)27-23(29)22-17-6-9-19(11-17)26-22/h2-5,7-8,12,17,19-20,22,26,28H,6,9-11H2,1H3,(H,27,29)/t17-,19+,20?,22-/m0/s1 VTAUSOLFMBFCJS-FGODIZBMSA-N 150388 US10238633, Example 62::US8987249, 62::US9713606, 62 Dipeptidyl peptidase 1 9.10 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150388 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150388&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430768 252824639 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732464 Cc1cc(-c2ccc(C[C@H](NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)c(F)c2)n(C)n1 InChI=1S/C21H24FN5O/c1-12-7-19(27(2)26-12)14-4-3-13(18(22)10-14)8-17(11-23)25-21(28)20-15-5-6-16(9-15)24-20/h3-4,7,10,15-17,20,24H,5-6,8-9H2,1-2H3,(H,25,28)/t15-,16+,17-,20-/m0/s1 HXPAVZPKUOICMH-CLWJZODNSA-N 150389 US10238633, Example 63::US8987249, 63 Dipeptidyl peptidase 1 9.30 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150389 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150389&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430840 252824640 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732465 CC(C)Cn1cc(cn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H28FN5O/c1-14(2)12-29-13-18(11-26-29)15-3-4-16(21(24)9-15)7-20(10-25)28-23(30)22-17-5-6-19(8-17)27-22/h3-4,9,11,13-14,17,19-20,22,27H,5-8,12H2,1-2H3,(H,28,30)/t17-,19+,20-,22-/m0/s1 QNSCLBGDVKDDPO-UFGBVDADSA-N 150390 US10238633, Example 64::US8987249, 64::US9713606, 64 Dipeptidyl peptidase 1 9.30 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150390&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430841 252824641 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732466 Cc1c(cnn1C)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H24FN5O/c1-12-18(11-24-27(12)2)13-3-4-14(19(22)9-13)7-17(10-23)26-21(28)20-15-5-6-16(8-15)25-20/h3-4,9,11,15-17,20,25H,5-8H2,1-2H3,(H,26,28)/t15-,16+,17?,20-/m0/s1 BXMGRZWIJVZYAS-YLPFRIKTSA-N 150391 US10238633, Example 65::US8987249, 65 Dipeptidyl peptidase 1 9.40 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150391&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430797 252824642 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732467 COc1ncc(cn1)-c1cn(nn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H23FN8O2/c1-34-23-26-10-15(11-27-23)20-12-32(31-30-20)18-5-3-13(19(24)8-18)6-17(9-25)29-22(33)21-14-2-4-16(7-14)28-21/h3,5,8,10-12,14,16-17,21,28H,2,4,6-7H2,1H3,(H,29,33)/t14-,16+,17-,21-/m0/s1 VYKOEQWAFLBCMG-CCFTVXDOSA-N 150392 US10238633, Example 66::US8987249, 66::US9713606, 66 Dipeptidyl peptidase 1 9.40 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150392 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150392&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937190 252824643 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732468 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-n1cc(nn1)C1CC1 InChI=1S/C21H23FN6O/c22-18-9-17(28-11-19(26-27-28)12-1-2-12)6-4-13(18)7-16(10-23)25-21(29)20-14-3-5-15(8-14)24-20/h4,6,9,11-12,14-16,20,24H,1-3,5,7-8H2,(H,25,29)/t14-,15+,16-,20-/m0/s1 XTPKWAUGRBRSMG-QOIOWGMHSA-N 150393 US10238633, Example 67::US8987249, 67::US9713606, 67 Dipeptidyl peptidase 1 9.60 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150393&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430347 252824644 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732469 CC(C)n1cc(cn1)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H26FN5O/c1-13(2)28-12-17(11-25-28)14-3-4-15(20(23)9-14)7-19(10-24)27-22(29)21-16-5-6-18(8-16)26-21/h3-4,9,11-13,16,18-19,21,26H,5-8H2,1-2H3,(H,27,29)/t16-,18+,19?,21-/m0/s1 KPULTUVWNZBBGM-PLPRGGQXSA-N 150394 US10238633, Example 68::US8987249, 68::US9713606, 68 Dipeptidyl peptidase 1 9.70 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150394&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430348 252824645 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732470 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cn[nH]c1 150395 US10238633, Example 69::US8987249, 69::US9713606, 69 Dipeptidyl peptidase 1 9.90 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150395 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150395&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430323 252824646 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732471 Cn1ncc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C25H24FN5O/c1-31-23-8-14(3-5-16(23)12-28-31)13-2-4-15(21(26)7-13)6-17(11-27)29-25(32)24-20-10-22(30-24)19-9-18(19)20/h2-5,7-8,12,17-20,22,24,30H,6,9-10H2,1H3,(H,29,32)/t17-,18+,19-,20+,22-,24-/m0/s1 QMOYISFVVPPPHT-BMSLZKTOSA-N 150396 US10238633, Example 70::US8987249, 70::US9713606, 70 Dipeptidyl peptidase 1 10.2 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150396 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150396&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430339 252824647 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732472 CCS(=O)(=O)c1ccc(cc1)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H26FN3O3S/c1-2-32(30,31)21-9-6-15(7-10-21)16-3-4-17(22(25)13-16)11-20(14-26)28-24(29)23-18-5-8-19(12-18)27-23/h3-4,6-7,9-10,13,18-20,23,27H,2,5,8,11-12H2,1H3,(H,28,29)/t18-,19+,20?,23-/m0/s1 AERARGOGTDRUGZ-SRDOODBNSA-N 150397 US10238633, Example 71::US8987249, 71::US9713606, 71 Dipeptidyl peptidase 1 10.8 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150397 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150397&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430349 252824648 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732473 CC(=O)c1ccc(s1)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H22FN3O2S/c1-12(27)19-6-7-20(29-19)14-3-2-13(18(23)10-14)8-17(11-24)26-22(28)21-15-4-5-16(9-15)25-21/h2-3,6-7,10,15-17,21,25H,4-5,8-9H2,1H3,(H,26,28)/t15-,16+,17?,21-/m0/s1 RBPTYWDZURRUTK-KWRFEPJMSA-N 150398 US10238633, Example 72::US8987249, 72::US9713606, 72 Dipeptidyl peptidase 1 10.8 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150398&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430316 252824649 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732474 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccco1 InChI=1S/C20H20FN3O2/c21-17-10-13(18-2-1-7-26-18)4-3-12(17)8-16(11-22)24-20(25)19-14-5-6-15(9-14)23-19/h1-4,7,10,14-16,19,23H,5-6,8-9H2,(H,24,25)/t14-,15+,16-,19-/m0/s1 XSWSPBCODWKSAB-RCJHGTSTSA-N 150399 US10238633, Example 73::US8987249, 73::US9713606, 73 Dipeptidyl peptidase 1 11.2 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150399 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150399&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430737 252824650 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732475 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnn(c1)C(=O)C1CCOCC1 InChI=1S/C25H28FN5O3/c26-22-11-16(19-13-28-31(14-19)25(33)15-5-7-34-8-6-15)1-2-17(22)9-21(12-27)30-24(32)23-18-3-4-20(10-18)29-23/h1-2,11,13-15,18,20-21,23,29H,3-10H2,(H,30,32)/t18-,20+,21-,23-/m0/s1 UAHSBFZVBPGAMM-SQMWVJLWSA-N 150400 US10238633, Example 74::US8987249, 74::US9713606, 74 Dipeptidyl peptidase 1 11.4 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150400 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150400&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443238 252824651 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732476 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccccc1 InChI=1S/C22H22FN3O/c23-20-12-15(14-4-2-1-3-5-14)6-7-16(20)10-19(13-24)26-22(27)21-17-8-9-18(11-17)25-21/h1-7,12,17-19,21,25H,8-11H2,(H,26,27)/t17-,18+,19-,21-/m0/s1 OIOPQZQMGBPXIP-JTJHWIPRSA-N 150401 US10238633, Example 75::US8987249, 75::US9713606, 75 Dipeptidyl peptidase 1 11.4 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150401 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150401&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430771 252824652 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732477 CN1Cc2cc(ccc2C1=O)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C25H25FN4O2/c1-30-13-18-8-14(5-7-21(18)25(30)32)15-2-3-16(22(26)11-15)9-20(12-27)29-24(31)23-17-4-6-19(10-17)28-23/h2-3,5,7-8,11,17,19-20,23,28H,4,6,9-10,13H2,1H3,(H,29,31)/t17-,19+,20?,23-/m0/s1 DYVYDWKPJKXISA-GKUGZCSRSA-N 150402 US10238633, Example 76::US8987249, 76::US9713606, 76 Dipeptidyl peptidase 1 11.7 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150402 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150402&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430726 252824653 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732478 COc1ccc(cc1OC)-c1cn(nn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C26H27FN6O3/c1-35-23-8-5-16(11-24(23)36-2)22-14-33(32-31-22)20-7-4-15(21(27)12-20)9-19(13-28)30-26(34)25-17-3-6-18(10-17)29-25/h4-5,7-8,11-12,14,17-19,25,29H,3,6,9-10H2,1-2H3,(H,30,34)/t17-,18+,19-,25-/m0/s1 OSHOVYZSVKRYIM-XMNZWCOLSA-N 150403 US10238633, Example 77::US8987249, 77::US9713606, 77 Dipeptidyl peptidase 1 11.9 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150403 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150403&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90440138 252824654 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732479 Fc1cc(ccc1CC(NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnn(c1)-c1ccccc1 InChI=1S/C25H24FN5O/c26-23-12-16(19-14-28-31(15-19)22-4-2-1-3-5-22)6-7-17(23)10-21(13-27)30-25(32)24-18-8-9-20(11-18)29-24/h1-7,12,14-15,18,20-21,24,29H,8-11H2,(H,30,32)/t18-,20+,21?,24-/m0/s1 DMZSQOLHWTVSKK-VVJUMWPSSA-N 150404 US10238633, Example 78::US8987249, 78::US9713606, 78 Dipeptidyl peptidase 1 12.0 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150404 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150404&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430773 252824655 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732480 Fc1cc(ccc1CC(NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2NC(=O)Cc2c1 InChI=1S/C24H23FN4O2/c25-20-10-14(13-4-6-21-17(7-13)11-22(30)29-21)1-2-15(20)8-19(12-26)28-24(31)23-16-3-5-18(9-16)27-23/h1-2,4,6-7,10,16,18-19,23,27H,3,5,8-9,11H2,(H,28,31)(H,29,30)/t16-,18+,19?,23-/m0/s1 CWSSERJVIIYICB-KLGBNGAQSA-N 150405 US10238633, Example 79::US8987249, 79::US9713606, 79 Dipeptidyl peptidase 1 12.0 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150405 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150405&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430606 252824656 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732481 Cc1nc(C)c(s1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H23FN4OS/c1-11-20(28-12(2)24-11)15-4-3-13(18(22)9-15)7-17(10-23)26-21(27)19-14-5-6-16(8-14)25-19/h3-4,9,14,16-17,19,25H,5-8H2,1-2H3,(H,26,27)/t14-,16+,17-,19-/m0/s1 BHLVXHBFLZCTGC-RUENVJTFSA-N 150406 US10238633, Example 80::US8987249, 80::US9713606, 80 Dipeptidyl peptidase 1 12.4 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150406 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150406&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430622 252824657 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732482 CN1C(=O)Cc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(Cl)c1 InChI=1S/C25H25ClN4O2/c1-30-22-11-15(3-5-17(22)12-23(30)31)14-2-4-16(21(26)10-14)8-20(13-27)29-25(32)24-18-6-7-19(9-18)28-24/h2-5,10-11,18-20,24,28H,6-9,12H2,1H3,(H,29,32)/t18-,19+,20-,24-/m0/s1 GNKBVILCETUBCX-VKDGWMQASA-N 370652 US10238633, Example 81 Dipeptidyl peptidase 1 13.1 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370652 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370652&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 130439771 402357632 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732483 CCC(C)(O)Cc1cn(nn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H29FN6O2/c1-3-23(2,32)11-18-13-30(29-28-18)19-7-5-14(20(24)10-19)8-17(12-25)27-22(31)21-15-4-6-16(9-15)26-21/h5,7,10,13,15-17,21,26,32H,3-4,6,8-9,11H2,1-2H3,(H,27,31)/t15-,16+,17-,21-,23?/m0/s1 VWKCUYRNWHGYTG-GHBDIUCWSA-N 150408 US10238633, Example 82::US8987249, 82::US9713606, 82 Dipeptidyl peptidase 1 13.1 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150408 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150408&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430623 252824659 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732484 NC(=O)c1ccc(cc1)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H23FN4O2/c24-20-11-15(13-1-3-14(4-2-13)22(26)29)5-6-16(20)9-19(12-25)28-23(30)21-17-7-8-18(10-17)27-21/h1-6,11,17-19,21,27H,7-10H2,(H2,26,29)(H,28,30)/t17-,18+,19?,21-/m0/s1 NQZMPJPNGZQKNA-VHRCFOOQSA-N 150409 US10238633, Example 83::US8987249, 83::US9713606, 83 Dipeptidyl peptidase 1 13.3 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150409 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150409&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430624 252824660 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732485 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-n1cc(nn1)-c1ccc2occc2c1 InChI=1S/C26H23FN6O2/c27-22-12-21(33-14-23(31-32-33)16-3-6-24-17(9-16)7-8-35-24)5-2-15(22)10-20(13-28)30-26(34)25-18-1-4-19(11-18)29-25/h2-3,5-9,12,14,18-20,25,29H,1,4,10-11H2,(H,30,34)/t18-,19+,20-,25-/m0/s1 RGXUCUBHDNKLOH-ZDQHKECQSA-N 150410 US10238633, Example 84::US8987249, 84::US9713606, 84 Dipeptidyl peptidase 1 13.7 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150410 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150410&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430617 252824661 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732486 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccsc1C#N InChI=1S/C21H19FN4OS/c22-18-9-12(17-5-6-28-19(17)11-24)1-2-13(18)7-16(10-23)26-21(27)20-14-3-4-15(8-14)25-20/h1-2,5-6,9,14-16,20,25H,3-4,7-8H2,(H,26,27)/t14-,15+,16-,20-/m0/s1 JBFGXPGASYJVIZ-QOIOWGMHSA-N 150411 US10238633, Example 85::US8987249, 85::US9713606, 85 Dipeptidyl peptidase 1 14.0 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150411 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150411&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430798 252824662 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732487 CS(=O)(=O)c1ccc(c(F)c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H23F2N3O3S/c1-32(30,31)18-6-7-19(21(25)11-18)13-2-3-14(20(24)10-13)8-17(12-26)28-23(29)22-15-4-5-16(9-15)27-22/h2-3,6-7,10-11,15-17,22,27H,4-5,8-9H2,1H3,(H,28,29)/t15-,16+,17-,22-/m0/s1 OPAJMLXYCWWNLW-GEYWLOKFSA-N 150412 US10238633, Example 86::US8987249, 86::US9713606, 86 Dipeptidyl peptidase 1 14.1 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150412 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150412&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430868 252824663 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732488 COCC(=O)n1cc(cn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H24FN5O3/c1-31-12-20(29)28-11-16(10-25-28)13-2-3-14(19(23)8-13)6-18(9-24)27-22(30)21-15-4-5-17(7-15)26-21/h2-3,8,10-11,15,17-18,21,26H,4-7,12H2,1H3,(H,27,30)/t15-,17+,18-,21-/m0/s1 SCGDLXUAKULUFJ-DKXUYOFUSA-N 150413 US10238633, Example 87::US8987249, 87::US9713606, 87 Dipeptidyl peptidase 1 14.2 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150413 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150413&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443239 252824664 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732489 CS(=O)(=O)c1cccc(c1)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H24FN3O3S/c1-31(29,30)20-4-2-3-14(11-20)15-5-6-16(21(24)12-15)9-19(13-25)27-23(28)22-17-7-8-18(10-17)26-22/h2-6,11-12,17-19,22,26H,7-10H2,1H3,(H,27,28)/t17-,18+,19?,22-/m0/s1 SLANNUBDKTXJNP-HJKBJPMPSA-N 150414 US10238633, Example 88::US8987249, 88::US9713606, 88 Dipeptidyl peptidase 1 15.2 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150414 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150414&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430806 252824665 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732490 CCC(O)Cc1cn(nn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H27FN6O2/c1-2-19(30)9-17-12-29(28-27-17)18-6-4-13(20(23)10-18)7-16(11-24)26-22(31)21-14-3-5-15(8-14)25-21/h4,6,10,12,14-16,19,21,25,30H,2-3,5,7-9H2,1H3,(H,26,31)/t14-,15+,16-,19?,21-/m0/s1 QBYQWVRYHRNFFO-NUDGSJNLSA-N 150415 US10238633, Example 89::US8987249, 89::US9713606, 89 Dipeptidyl peptidase 1 15.6 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150415&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430796 252824666 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732491 CC(=O)c1cn(nn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C20H21FN6O2/c1-11(28)18-10-27(26-25-18)16-5-3-12(17(21)8-16)6-15(9-22)24-20(29)19-13-2-4-14(7-13)23-19/h3,5,8,10,13-15,19,23H,2,4,6-7H2,1H3,(H,24,29)/t13-,14+,15-,19-/m0/s1 JCEDMPSWCYIJPG-YGTYGHESSA-N 150416 US10238633, Example 90::US8987249, 90::US9713606, 90 Dipeptidyl peptidase 1 16.0 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150416 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150416&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430807 252824667 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732492 CS(=O)(=O)N1CCN(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H28FN5O3S/c1-31(29,30)27-8-6-26(7-9-27)18-5-3-14(19(22)12-18)10-17(13-23)25-21(28)20-15-2-4-16(11-15)24-20/h3,5,12,15-17,20,24H,2,4,6-11H2,1H3,(H,25,28)/t15-,16+,17-,20-/m0/s1 YKWPCSVFBUCYCD-CLWJZODNSA-N 150417 US10238633, Example 91::US8987249, 91::US9713606, 91 Dipeptidyl peptidase 1 17.0 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150417 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150417&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430749 252824668 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732493 Cc1occc1-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H22FN3O2/c1-12-18(6-7-27-12)13-2-3-14(19(22)10-13)8-17(11-23)25-21(26)20-15-4-5-16(9-15)24-20/h2-3,6-7,10,15-17,20,24H,4-5,8-9H2,1H3,(H,25,26)/t15-,16+,17?,20-/m0/s1 SJILLKINMISQMS-YLPFRIKTSA-N 150418 US10238633, Example 92::US8987249, 92 Dipeptidyl peptidase 1 17.7 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150418&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430791 252824669 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732494 Cc1ncc(s1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C21H21FN4OS/c1-10-24-9-19(28-10)12-3-2-11(17(22)5-12)4-13(8-23)25-21(27)20-16-7-18(26-20)15-6-14(15)16/h2-3,5,9,13-16,18,20,26H,4,6-7H2,1H3,(H,25,27)/t13-,14+,15-,16+,18-,20-/m0/s1 XTPZCJCPIUDBMC-SHIIKYBRSA-N 150419 US10238633, Example 93::US8987249, 93::US9713606, 93 Dipeptidyl peptidase 1 18.3 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150419 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150419&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430767 252824670 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732495 COc1cccc(c1)-c1cn(nn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C25H25FN6O2/c1-34-21-4-2-3-16(11-21)23-14-32(31-30-23)20-8-6-15(22(26)12-20)9-19(13-27)29-25(33)24-17-5-7-18(10-17)28-24/h2-4,6,8,11-12,14,17-19,24,28H,5,7,9-10H2,1H3,(H,29,33)/t17-,18+,19-,24-/m0/s1 BVKSOIQSAWREHK-YDLHNXBPSA-N 150420 US10238633, Example 94::US8987249, 94::US9713606, 94 Dipeptidyl peptidase 1 18.7 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150420 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150420&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430792 252824671 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732496 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2CNC(=O)c2c1 InChI=1S/C24H23FN4O2/c25-21-10-14(13-2-4-17-12-27-23(30)20(17)9-13)1-3-15(21)7-19(11-26)29-24(31)22-16-5-6-18(8-16)28-22/h1-4,9-10,16,18-19,22,28H,5-8,12H2,(H,27,30)(H,29,31)/t16-,18+,19-,22-/m0/s1 YVPAYTOMTQVUAC-ZBPHCFQXSA-N 150421 US10238633, Example 95::US8987249, 95::US9713606, 95 Dipeptidyl peptidase 1 19.2 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150421 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150421&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430778 252824672 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732497 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cc(no1)-c1ccccc1 InChI=1S/C25H23FN4O2/c26-21-12-17(23-13-22(30-32-23)15-4-2-1-3-5-15)7-6-16(21)10-20(14-27)29-25(31)24-18-8-9-19(11-18)28-24/h1-7,12-13,18-20,24,28H,8-11H2,(H,29,31)/t18-,19+,20-,24-/m0/s1 QESWGIWAZDKMDD-VKDGWMQASA-N 150422 US10238633, Example 96::US8987249, 96::US9713606, 96 Dipeptidyl peptidase 1 19.8 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150422 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150422&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430750 252824673 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732498 COCCn1cc(cn1)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H26FN5O2/c1-30-7-6-28-13-17(12-25-28)14-2-3-15(20(23)10-14)8-19(11-24)27-22(29)21-16-4-5-18(9-16)26-21/h2-3,10,12-13,16,18-19,21,26H,4-9H2,1H3,(H,27,29)/t16-,18+,19?,21-/m0/s1 IQMJMZXJSJWJBP-PLPRGGQXSA-N 150423 US10238633, Example 97::US8987249, 97::US9713606, 97 Dipeptidyl peptidase 1 19.9 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150423 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150423&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430842 252824674 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732499 Fc1cc(ccc1CC(NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ncc(Cl)cn1 InChI=1S/C20H19ClFN5O/c21-14-9-24-19(25-10-14)13-2-1-11(17(22)7-13)5-16(8-23)27-20(28)18-12-3-4-15(6-12)26-18/h1-2,7,9-10,12,15-16,18,26H,3-6H2,(H,27,28)/t12-,15+,16?,18-/m0/s1 AKPGVXYITPFJOW-UDOSGHBDSA-N 150424 US10238633, Example 98::US8987249, 98::US9713606, 98 Dipeptidyl peptidase 1 20.3 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150424 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150424&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430870 252824675 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732500 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-n1cc(CCN2CCOCC2)nn1 InChI=1S/C24H30FN7O2/c25-22-13-21(32-15-19(29-30-32)5-6-31-7-9-34-10-8-31)4-2-16(22)11-20(14-26)28-24(33)23-17-1-3-18(12-17)27-23/h2,4,13,15,17-18,20,23,27H,1,3,5-12H2,(H,28,33)/t17-,18+,20-,23-/m0/s1 MYILWBBNYUAXDA-KQZHTCIUSA-N 150425 US10238633, Example 99::US8987249, 99::US9713606, 99 Dipeptidyl peptidase 1 21.1 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150425 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150425&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937191 252824676 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732501 Cn1nc(cc1-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1)C(F)(F)F InChI=1S/C21H21F4N5O/c1-30-17(9-18(29-30)21(23,24)25)12-3-2-11(16(22)8-12)6-15(10-26)28-20(31)19-13-4-5-14(7-13)27-19/h2-3,8-9,13-15,19,27H,4-7H2,1H3,(H,28,31)/t13-,14+,15-,19-/m0/s1 MYYLJSMDWKTSJL-YGTYGHESSA-N 150426 US10238633, Example 100::US8987249, 100::US9713606, 100 Dipeptidyl peptidase 1 22.3 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150426 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150426&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430809 252824677 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732502 CC(O)Cc1cn(nn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H25FN6O2/c1-12(29)6-17-11-28(27-26-17)18-5-3-13(19(22)9-18)7-16(10-23)25-21(30)20-14-2-4-15(8-14)24-20/h3,5,9,11-12,14-16,20,24,29H,2,4,6-8H2,1H3,(H,25,30)/t12?,14-,15+,16-,20-/m0/s1 CMGDKMRQSURTJI-VPRMXFSVSA-N 150427 US10238633, Example 101::US8987249, 101::US9713606, 101 Dipeptidyl peptidase 1 23.9 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150427 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150427&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430871 252824678 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732503 Fc1cc(ccc1CC(NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnc(Cl)cn1 InChI=1S/C20H19ClFN5O/c21-18-10-24-17(9-25-18)12-2-1-11(16(22)7-12)5-15(8-23)27-20(28)19-13-3-4-14(6-13)26-19/h1-2,7,9-10,13-15,19,26H,3-6H2,(H,27,28)/t13-,14+,15?,19-/m0/s1 JGOVHYJPZVPVCA-FKGKKHCZSA-N 150428 US10238633, Example 102::US8987249, 102::US9713606, 102 Dipeptidyl peptidase 1 24.8 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150428 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150428&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430843 252824679 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732504 Fc1cc(ccc1CC(NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccoc1 InChI=1S/C20H20FN3O2/c21-18-9-12(15-5-6-26-11-15)1-2-13(18)7-17(10-22)24-20(25)19-14-3-4-16(8-14)23-19/h1-2,5-6,9,11,14,16-17,19,23H,3-4,7-8H2,(H,24,25)/t14-,16+,17?,19-/m0/s1 BNIARBLPIAJFIM-QSBFGILCSA-N 150429 US10238633, Example 103::US8987249, 103::US9713606, 103 Dipeptidyl peptidase 1 24.9 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150429 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150429&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430384 252824680 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732505 Cc1n[nH]cc1-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 150430 US10238633, Example 104::US8987249, 104::US9713606, 104 Dipeptidyl peptidase 1 24.9 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150430 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150430&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430365 252824681 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732506 CCOCc1cn(nn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H25FN6O2/c1-2-30-12-17-11-28(27-26-17)18-6-4-13(19(22)9-18)7-16(10-23)25-21(29)20-14-3-5-15(8-14)24-20/h4,6,9,11,14-16,20,24H,2-3,5,7-8,12H2,1H3,(H,25,29)/t14-,15+,16-,20-/m0/s1 ABSBTIIBDKCMEG-QOIOWGMHSA-N 150431 US10238633, Example 105::US8987249, 105::US9713606, 105 Dipeptidyl peptidase 1 25.0 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150431 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150431&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430366 252824682 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732507 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-n1cc(COC(=O)N2CCCC2)nn1 InChI=1S/C24H28FN7O3/c25-21-11-20(32-13-19(29-30-32)14-35-24(34)31-7-1-2-8-31)6-4-15(21)9-18(12-26)28-23(33)22-16-3-5-17(10-16)27-22/h4,6,11,13,16-18,22,27H,1-3,5,7-10,14H2,(H,28,33)/t16-,17+,18-,22-/m0/s1 SCQBGLUSDQKNSV-SUWCGCSTSA-N 150432 US10238633, Example 106::US8987249, 106::US9713606, 106 Dipeptidyl peptidase 1 25.9 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150432&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430334 252824683 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732508 Cn1c2ccc(cc2oc1=O)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H23FN4O3/c1-29-20-7-5-14(11-21(20)32-24(29)31)13-2-3-15(19(25)10-13)8-18(12-26)28-23(30)22-16-4-6-17(9-16)27-22/h2-3,5,7,10-11,16-18,22,27H,4,6,8-9H2,1H3,(H,28,30)/t16-,17+,18?,22-/m0/s1 HSOUISMKPAKWDA-QOPFVKLFSA-N 150433 US10238633, Example 107::US8987249, 107::US9713606, 107 Dipeptidyl peptidase 1 25.9 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150433 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150433&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430367 252824684 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732509 Fc1cc(ccc1CC(NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc(Cl)nn1 InChI=1S/C20H19ClFN5O/c21-18-6-5-17(26-27-18)12-2-1-11(16(22)9-12)7-15(10-23)25-20(28)19-13-3-4-14(8-13)24-19/h1-2,5-6,9,13-15,19,24H,3-4,7-8H2,(H,25,28)/t13-,14+,15?,19-/m0/s1 HEBPAARTHZGYLM-FKGKKHCZSA-N 150434 US10238633, Example 108::US8987249, 108::US9713606, 108 Dipeptidyl peptidase 1 26.4 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150434 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150434&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430436 252824685 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732510 CC(C)C(O)Cc1cn(nn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H29FN6O2/c1-13(2)21(31)9-18-12-30(29-28-18)19-6-4-14(20(24)10-19)7-17(11-25)27-23(32)22-15-3-5-16(8-15)26-22/h4,6,10,12-13,15-17,21-22,26,31H,3,5,7-9H2,1-2H3,(H,27,32)/t15-,16+,17-,21?,22-/m0/s1 WYCZQJCBELHBNC-UBQHZJADSA-N 150435 US10238633, Example 109::US8987249, 109::US9713606, 109 Dipeptidyl peptidase 1 26.9 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150435 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150435&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430391 252824686 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732511 CCn1nccc1-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H24FN5O/c1-2-27-19(7-8-24-27)14-4-3-13(18(22)11-14)9-17(12-23)26-21(28)20-15-5-6-16(10-15)25-20/h3-4,7-8,11,15-17,20,25H,2,5-6,9-10H2,1H3,(H,26,28)/t15-,16+,17-,20-/m0/s1 IHPAWNTVVZQHFV-CLWJZODNSA-N 150436 US10238633, Example 110::US8987249, 110::US9713606, 110 Dipeptidyl peptidase 1 28.6 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150436 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150436&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430785 252824687 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732512 COCc1cn(nn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C20H23FN6O2/c1-29-11-16-10-27(26-25-16)17-5-3-12(18(21)8-17)6-15(9-22)24-20(28)19-13-2-4-14(7-13)23-19/h3,5,8,10,13-15,19,23H,2,4,6-7,11H2,1H3,(H,24,28)/t13-,14+,15-,19-/m0/s1 YUYZMIRSJWARNU-YGTYGHESSA-N 150437 US10238633, Example 111::US8987249, 111::US9713606, 111 Dipeptidyl peptidase 1 31.8 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150437 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150437&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430786 252824688 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732513 COCCOCc1cn(nn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H27FN6O3/c1-31-6-7-32-13-18-12-29(28-27-18)19-5-3-14(20(23)10-19)8-17(11-24)26-22(30)21-15-2-4-16(9-15)25-21/h3,5,10,12,15-17,21,25H,2,4,6-9,13H2,1H3,(H,26,30)/t15-,16+,17-,21-/m0/s1 ZUVPKRLLJRNURX-DLRJPAPCSA-N 150438 US10238633, Example 112::US8987249, 112::US9713606, 112 Dipeptidyl peptidase 1 33.3 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150438 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150438&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90440140 252824689 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732514 CCc1ncc(s1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C22H23FN4OS/c1-2-20-25-10-19(29-20)12-4-3-11(17(23)6-12)5-13(9-24)26-22(28)21-16-8-18(27-21)15-7-14(15)16/h3-4,6,10,13-16,18,21,27H,2,5,7-8H2,1H3,(H,26,28)/t13-,14+,15-,16+,18-,21-/m0/s1 MBNDRKVILGAANK-OAXXGVFQSA-N 150439 US10238633, Example 113::US8987249, 113::US9713606, 113 Dipeptidyl peptidase 1 36.4 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150439 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150439&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430779 252824690 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732515 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cc[nH]n1 150440 US10238633, Example 114::US8987249, 114::US9713606, 114 Dipeptidyl peptidase 1 36.7 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150440 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150440&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430751 252824691 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732516 OC(=O)c1ccc(s1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H20FN3O3S/c22-16-9-12(17-5-6-18(29-17)21(27)28)2-1-11(16)7-15(10-23)25-20(26)19-13-3-4-14(8-13)24-19/h1-2,5-6,9,13-15,19,24H,3-4,7-8H2,(H,25,26)(H,27,28)/t13-,14+,15-,19-/m0/s1 UKXCOIVMRZGJFO-YGTYGHESSA-N 150441 US10238633, Example 115::US8987249, 115::US9713606, 115 Dipeptidyl peptidase 1 37.8 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150441&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430738 252824692 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732517 Fc1cc(ccc1CC(NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnn(c1)C1CCOCC1 InChI=1S/C24H28FN5O2/c25-22-11-15(18-13-27-30(14-18)21-5-7-32-8-6-21)1-2-16(22)9-20(12-26)29-24(31)23-17-3-4-19(10-17)28-23/h1-2,11,13-14,17,19-21,23,28H,3-10H2,(H,29,31)/t17-,19+,20?,23-/m0/s1 BPAHCPXZVBMFNE-GKUGZCSRSA-N 150442 US10238633, Example 116::US8987249, 116::US9713606, 116 Dipeptidyl peptidase 1 39.1 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150442 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150442&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430739 252824693 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732518 CN1CCC(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H29FN4O/c1-27-8-6-14(7-9-27)15-2-3-16(20(23)12-15)10-19(13-24)26-22(28)21-17-4-5-18(11-17)25-21/h2-3,12,14,17-19,21,25H,4-11H2,1H3,(H,26,28)/t17-,18+,19-,21-/m0/s1 HNBAKPJBZUSZLD-JTJHWIPRSA-N 150443 US10238633, Example 117::US8987249, 117::US9713606, 117 Dipeptidyl peptidase 1 39.6 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150443&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430745 252824694 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732519 Cn1cc(c(n1)C(F)(F)F)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H21F4N5O/c1-30-10-16(19(29-30)21(23,24)25)11-2-3-12(17(22)8-11)6-15(9-26)28-20(31)18-13-4-5-14(7-13)27-18/h2-3,8,10,13-15,18,27H,4-7H2,1H3,(H,28,31)/t13-,14+,15-,18-/m0/s1 ZEAZPEMJKLJBFP-KRXQYRFLSA-N 150444 US10238633, Example 118::US8987249, 118::US9713606, 118 Dipeptidyl peptidase 1 44.3 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150444 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150444&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430604 252824695 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732520 COc1ccccc1-c1cn(nn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C25H25FN6O2/c1-34-23-5-3-2-4-20(23)22-14-32(31-30-22)19-9-7-15(21(26)12-19)10-18(13-27)29-25(33)24-16-6-8-17(11-16)28-24/h2-5,7,9,12,14,16-18,24,28H,6,8,10-11H2,1H3,(H,29,33)/t16-,17+,18-,24-/m0/s1 FMWUNAUOLVVZHN-AIDSWVIKSA-N 150445 US10238633, Example 119::US8987249, 119::US9713606, 119 Dipeptidyl peptidase 1 51.2 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150445&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90440141 252824696 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732521 CN1C(=O)Cc2ccc(cc12)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(O)c1 InChI=1S/C25H26N4O3/c1-29-21-10-14(2-4-16(21)12-23(29)31)15-3-5-17(22(30)11-15)8-20(13-26)28-25(32)24-18-6-7-19(9-18)27-24/h2-5,10-11,18-20,24,27,30H,6-9,12H2,1H3,(H,28,32)/t18-,19+,20?,24-/m0/s1 YXZHSQPRBJFDQC-BQTZMPSMSA-N 150446 US10238633, Example 120::US8987249, 120::US9713606, 120 Dipeptidyl peptidase 1 55.6 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150446&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430568 252824697 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732522 Cc1noc(C)c1-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H23FN4O2/c1-11-19(12(2)28-26-11)14-4-3-13(18(22)9-14)7-17(10-23)25-21(27)20-15-5-6-16(8-15)24-20/h3-4,9,15-17,20,24H,5-8H2,1-2H3,(H,25,27)/t15-,16+,17-,20-/m0/s1 PHUAZJBZKNQTIM-CLWJZODNSA-N 150447 US10238633, Example 121::US8987249, 121::US9713606, 121 Dipeptidyl peptidase 1 156 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150447&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430644 252824698 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732523 CN1C(=O)Cc2ccc(cc12)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(OCc2ccccc2)c1 InChI=1S/C32H32N4O3/c1-36-28-15-21(7-9-23(28)17-30(36)37)22-8-10-24(29(16-22)39-19-20-5-3-2-4-6-20)13-27(18-33)35-32(38)31-25-11-12-26(14-25)34-31/h2-10,15-16,25-27,31,34H,11-14,17,19H2,1H3,(H,35,38)/t25-,26+,27?,31-/m0/s1 VGNUUKUQMUQSQR-NKFYVHBOSA-N 150448 US10238633, Example 122::US8987249, 122::US9713606, 122 Dipeptidyl peptidase 1 182 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150448&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430655 252824699 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732524 O=C(NC(Cc1ccc2c(c1)[nH]c(=O)c1ccccc21)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 150449 US10238633, Example 123::US8987249, 123::US9713606, 123 Dipeptidyl peptidase 1 187 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150449 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150449&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937192 252824700 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732525 CC(C)OCc1cn(nn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H27FN6O2/c1-13(2)31-12-18-11-29(28-27-18)19-6-4-14(20(23)9-19)7-17(10-24)26-22(30)21-15-3-5-16(8-15)25-21/h4,6,9,11,13,15-17,21,25H,3,5,7-8,12H2,1-2H3,(H,26,30)/t15-,16+,17-,21-/m0/s1 QPKNBTUQMSLXJI-DLRJPAPCSA-N 150450 US10238633, Example 124::US8987249, 124::US9713606, 124 Dipeptidyl peptidase 1 187 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150450 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150450&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430741 252824701 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732526 CN1CCN(C(=O)C1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H26FN5O2/c1-26-6-7-27(19(28)12-26)17-5-3-13(18(22)10-17)8-16(11-23)25-21(29)20-14-2-4-15(9-14)24-20/h3,5,10,14-16,20,24H,2,4,6-9,12H2,1H3,(H,25,29)/t14-,15+,16-,20-/m0/s1 HXBNPWRCCJXQEN-QOIOWGMHSA-N 150451 US10238633, Example 125::US8987249, 125::US9713606, 125 Dipeptidyl peptidase 1 206 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150451 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150451&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430608 252824702 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732527 Cc1cnn(C)c1-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H24FN5O/c1-12-11-24-27(2)20(12)15-4-3-13(18(22)9-15)7-17(10-23)26-21(28)19-14-5-6-16(8-14)25-19/h3-4,9,11,14,16-17,19,25H,5-8H2,1-2H3,(H,26,28)/t14-,16+,17-,19-/m0/s1 FIDRPXYSWGIXNB-RUENVJTFSA-N 150452 US10238633, Example 126::US8987249, 126::US9713606, 126 Dipeptidyl peptidase 1 275 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150452 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150452&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430625 252824703 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732528 O=C(NC(Cc1ccc2cn[nH]c2c1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 150453 US10238633, Example 127::US8987249, 127::US9713606, 127 Dipeptidyl peptidase 1 860 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150453 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150453&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430742 252824704 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732529 O=C(NC(Cc1cccc2[nH]c(=O)c3ccccc3c12)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 150454 US10238633, Example 128::US8987249, 128::US9713606, 128 Dipeptidyl peptidase 1 2393 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150454 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150454&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937193 252824705 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732530 Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C25H23FN4O3/c1-30-21-8-13(4-5-22(21)33-25(30)32)12-2-3-14(19(26)7-12)6-15(11-27)28-24(31)23-18-10-20(29-23)17-9-16(17)18/h2-5,7-8,15-18,20,23,29H,6,9-10H2,1H3,(H,28,31)/t15-,16+,17-,18+,20-,23-/m0/s1 FUXYTNBGQFZKOD-MPYHZQTKSA-N 150455 US10238633, Example 129::US8987249, 129::US9713606, 129 Dipeptidyl peptidase 1 82.7 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150455 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150455&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90440142 252824706 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732531 NC(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C24H23FN4O2/c25-20-8-14(12-1-3-13(4-2-12)23(27)30)5-6-15(20)7-16(11-26)28-24(31)22-19-10-21(29-22)18-9-17(18)19/h1-6,8,16-19,21-22,29H,7,9-10H2,(H2,27,30)(H,28,31)/t16-,17+,18-,19+,21-,22-/m0/s1 XBPOSPXPHLIHFW-RVEDGADZSA-N 150456 US10238633, Example 130::US8987249, 130::US9713606, 130 Dipeptidyl peptidase 1 43.5 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150456 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150456&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430390 252824707 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732532 CC(=O)Nc1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C25H25FN4O2/c1-13(31)28-17-6-4-14(5-7-17)15-2-3-16(22(26)9-15)8-18(12-27)29-25(32)24-21-11-23(30-24)20-10-19(20)21/h2-7,9,18-21,23-24,30H,8,10-11H2,1H3,(H,28,31)(H,29,32)/t18-,19+,20-,21+,23-,24-/m0/s1 SJDNSJYCAUFUFP-KXNGWZAWSA-N 150457 US10238633, Example 131::US8987249, 131::US9713606, 131 Dipeptidyl peptidase 1 139 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150457 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150457&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430333 252824708 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732533 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@H]2C[C@@H]1[C@@H]1C[C@H]21)C#N)-c1ccc(C#N)c(F)c1 InChI=1S/C24H20F2N4O/c25-20-6-12(13-2-4-15(10-27)21(26)7-13)1-3-14(20)5-16(11-28)29-24(31)23-19-9-22(30-23)18-8-17(18)19/h1-4,6-7,16-19,22-23,30H,5,8-9H2,(H,29,31)/t16-,17+,18-,19+,22-,23-/m0/s1 VUMXUAUWTBHETB-SFJJLGKISA-N 150458 US10238633, Example 132::US8987249, 132::US9713606, 132 Dipeptidyl peptidase 1 18.9 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150458&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430755 252824709 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732534 COC(=O)c1cc(cs1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C23H22FN3O3S/c1-30-23(29)20-6-13(10-31-20)11-2-3-12(18(24)5-11)4-14(9-25)26-22(28)21-17-8-19(27-21)16-7-15(16)17/h2-3,5-6,10,14-17,19,21,27H,4,7-8H2,1H3,(H,26,28)/t14-,15+,16-,17+,19-,21-/m0/s1 YCGQHGQZFQYOAZ-TXQSJXHQSA-N 150459 US10238633, Example 133::US8987249, 133::US9713606, 133 Dipeptidyl peptidase 1 16.1 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150459&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90440143 252824710 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732535 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@H]2C[C@@H]1[C@@H]1C[C@H]21)C#N)-c1ccc2NC(=O)Cc2c1 InChI=1S/C25H23FN4O2/c26-20-7-13(12-3-4-21-15(5-12)8-23(31)29-21)1-2-14(20)6-16(11-27)28-25(32)24-19-10-22(30-24)18-9-17(18)19/h1-5,7,16-19,22,24,30H,6,8-10H2,(H,28,32)(H,29,31)/t16-,17+,18-,19+,22-,24-/m0/s1 BPBLBLWVDZTDMM-LADXIUKTSA-N 150460 US10238633, Example 134::US8987249, 134::US9713606, 134 Dipeptidyl peptidase 1 17.8 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150460 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150460&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430759 252824711 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732536 Cn1cc2ccc(cc2n1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C25H24FN5O/c1-31-12-16-5-3-14(8-22(16)30-31)13-2-4-15(21(26)7-13)6-17(11-27)28-25(32)24-20-10-23(29-24)19-9-18(19)20/h2-5,7-8,12,17-20,23-24,29H,6,9-10H2,1H3,(H,28,32)/t17-,18+,19-,20+,23-,24-/m0/s1 OIWYRYIPQPDPIM-XJMWNJKVSA-N 150461 US10238633, Example 135::US8987249, 135::US9713606, 135 Dipeptidyl peptidase 1 286 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150461 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150461&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430782 252824712 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732537 NS(=O)(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C23H23FN4O3S/c24-20-8-13(12-3-5-16(6-4-12)32(26,30)31)1-2-14(20)7-15(11-25)27-23(29)22-19-10-21(28-22)18-9-17(18)19/h1-6,8,15,17-19,21-22,28H,7,9-10H2,(H,27,29)(H2,26,30,31)/t15-,17+,18-,19+,21-,22-/m0/s1 KQPFXAKCEUMOIW-LNHKNWPKSA-N 150462 US10238633, Example 136::US8987249, 136::US9713606, 136 Dipeptidyl peptidase 1 10.2 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150462 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150462&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937194 252824713 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732538 Cn1ncc2cc(ccc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C25H24FN5O/c1-31-23-5-4-13(6-16(23)12-28-31)14-2-3-15(21(26)8-14)7-17(11-27)29-25(32)24-20-10-22(30-24)19-9-18(19)20/h2-6,8,12,17-20,22,24,30H,7,9-10H2,1H3,(H,29,32)/t17-,18+,19-,20+,22-,24-/m0/s1 CHXQHZPGIICLSV-BMSLZKTOSA-N 150463 US10238633, Example 137::US8987249, 137::US9713606, 137 Dipeptidyl peptidase 1 59.7 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150463 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150463&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430204 252824714 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732539 CCn1cc(cn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C22H24FN5O/c1-2-28-11-14(10-25-28)12-3-4-13(19(23)6-12)5-15(9-24)26-22(29)21-18-8-20(27-21)17-7-16(17)18/h3-4,6,10-11,15-18,20-21,27H,2,5,7-8H2,1H3,(H,26,29)/t15-,16+,17-,18+,20-,21-/m0/s1 AOKRMUHLKCKEIK-FJEWGBTGSA-N 150464 US10238633, Example 138::US8987249, 138::US9713606, 138 Dipeptidyl peptidase 1 14.5 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150464 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150464&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430254 252824715 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732540 CS(=O)(=O)Nc1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C24H25FN4O3S/c1-33(31,32)29-16-4-2-3-13(7-16)14-5-6-15(21(25)9-14)8-17(12-26)27-24(30)23-20-11-22(28-23)19-10-18(19)20/h2-7,9,17-20,22-23,28-29H,8,10-11H2,1H3,(H,27,30)/t17-,18+,19-,20+,22-,23-/m0/s1 XHJXZNFMYRTAPM-IYDLXWBISA-N 150465 US10238633, Example 139::US8987249, 139::US9713606, 139 Dipeptidyl peptidase 1 11.7 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150465 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150465&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937195 252824716 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732541 CS(=O)(=O)Nc1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C24H25FN4O3S/c1-33(31,32)29-16-6-4-13(5-7-16)14-2-3-15(21(25)9-14)8-17(12-26)27-24(30)23-20-11-22(28-23)19-10-18(19)20/h2-7,9,17-20,22-23,28-29H,8,10-11H2,1H3,(H,27,30)/t17-,18+,19-,20+,22-,23-/m0/s1 BCAZJKORVAFQTP-IYDLXWBISA-N 150466 US10238633, Example 140::US8987249, 140::US9713606, 140 Dipeptidyl peptidase 1 21.5 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150466 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150466&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430222 252824717 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732542 CS(=O)(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C24H24FN3O3S/c1-32(30,31)17-6-4-13(5-7-17)14-2-3-15(21(25)9-14)8-16(12-26)27-24(29)23-20-11-22(28-23)19-10-18(19)20/h2-7,9,16,18-20,22-23,28H,8,10-11H2,1H3,(H,27,29)/t16-,18+,19-,20+,22-,23-/m0/s1 UYWCFMFTAPJUIH-VUPWWPOFSA-N 150467 US10238633, Example 141::US8987249, 141::US9713606, 141 Dipeptidyl peptidase 1 36.6 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150467 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150467&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90440144 252824718 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732543 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@H]2C[C@@H]1[C@@H]1C[C@H]21)C#N)-c1ccc(nc1)C#N InChI=1S/C23H20FN5O/c24-20-6-12(14-3-4-15(9-25)27-11-14)1-2-13(20)5-16(10-26)28-23(30)22-19-8-21(29-22)18-7-17(18)19/h1-4,6,11,16-19,21-22,29H,5,7-8H2,(H,28,30)/t16-,17+,18-,19+,21-,22-/m0/s1 XEYBRPMUORQYDN-RVEDGADZSA-N 150468 US10238633, Example 142::US8987249, 142::US9713606, 142 Dipeptidyl peptidase 1 63.1 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150468 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150468&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430618 252824719 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732544 NS(=O)(=O)c1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C23H23FN4O3S/c24-20-8-13(12-2-1-3-16(7-12)32(26,30)31)4-5-14(20)6-15(11-25)27-23(29)22-19-10-21(28-22)18-9-17(18)19/h1-5,7-8,15,17-19,21-22,28H,6,9-10H2,(H,27,29)(H2,26,30,31)/t15-,17+,18-,19+,21-,22-/m0/s1 FWBVDUGYEFVZSF-LNHKNWPKSA-N 150469 US10238633, Example 143::US8987249, 143::US9713606, 143 Dipeptidyl peptidase 1 6.70 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150469 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150469&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430485 252824720 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732545 CS(=O)(=O)c1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C24H24FN3O3S/c1-32(30,31)17-4-2-3-13(8-17)14-5-6-15(21(25)9-14)7-16(12-26)27-24(29)23-20-11-22(28-23)19-10-18(19)20/h2-6,8-9,16,18-20,22-23,28H,7,10-11H2,1H3,(H,27,29)/t16-,18+,19-,20+,22-,23-/m0/s1 YEGLUNIHKAHCKL-VUPWWPOFSA-N 150470 US10238633, Example 144::US8987249, 144::US9713606, 144 Dipeptidyl peptidase 1 26.3 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150470 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150470&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430627 252824721 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732546 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@H]2C[C@@H]1[C@@H]1C[C@H]21)C#N)-c1ccc(Cl)nc1 InChI=1S/C22H20ClFN4O/c23-20-4-3-13(10-26-20)11-1-2-12(18(24)6-11)5-14(9-25)27-22(29)21-17-8-19(28-21)16-7-15(16)17/h1-4,6,10,14-17,19,21,28H,5,7-8H2,(H,27,29)/t14-,15+,16-,17+,19-,21-/m0/s1 ZGRYOFAIQXJOSA-TXQSJXHQSA-N 150471 US10238633, Example 145::US8987249, 145::US9713606, 145 Dipeptidyl peptidase 1 53.8 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150471 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150471&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430628 252824722 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732547 NC(=O)c1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C24H23FN4O2/c25-20-8-13(12-2-1-3-15(6-12)23(27)30)4-5-14(20)7-16(11-26)28-24(31)22-19-10-21(29-22)18-9-17(18)19/h1-6,8,16-19,21-22,29H,7,9-10H2,(H2,27,30)(H,28,31)/t16-,17+,18-,19+,21-,22-/m0/s1 MVZGYAKRZLZBEL-RVEDGADZSA-N 150472 US10238633, Example 146::US8987249, 146::US9713606, 146 Dipeptidyl peptidase 1 30.5 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150472 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150472&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430629 252824723 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732548 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@H]2C[C@@H]1[C@@H]1C[C@H]21)C#N)-c1ccc2C(=O)NCc2c1 InChI=1S/C25H23FN4O2/c26-21-7-13(12-3-4-17-15(5-12)11-28-24(17)31)1-2-14(21)6-16(10-27)29-25(32)23-20-9-22(30-23)19-8-18(19)20/h1-5,7,16,18-20,22-23,30H,6,8-9,11H2,(H,28,31)(H,29,32)/t16-,18+,19-,20+,22-,23-/m0/s1 XGTPTZPXCXMRBF-VUPWWPOFSA-N 150473 US10238633, Example 147::US8987249, 147::US9713606, 147 Dipeptidyl peptidase 1 6.20 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150473 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150473&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430679 252824724 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732549 Fc1cc(ccc1CC(NC(=O)[C@H]1N[C@H]2C[C@@H]1[C@@H]1C[C@H]21)C#N)-c1ccc2C(=O)NCCc2c1 InChI=1S/C26H25FN4O2/c27-22-9-14(13-3-4-18-15(7-13)5-6-29-25(18)32)1-2-16(22)8-17(12-28)30-26(33)24-21-11-23(31-24)20-10-19(20)21/h1-4,7,9,17,19-21,23-24,31H,5-6,8,10-11H2,(H,29,32)(H,30,33)/t17?,19-,20+,21-,23+,24+/m1/s1 KLLOKUHZQAWUNF-IFZHGGHTSA-N 150474 US10238633, Example 148::US8987249, 148::US9713606, 148 Dipeptidyl peptidase 1 30.4 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150474&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430572 252824725 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732550 CN1Cc2cc(ccc2C1=O)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C26H25FN4O2/c1-31-12-16-6-13(4-5-18(16)26(31)33)14-2-3-15(22(27)8-14)7-17(11-28)29-25(32)24-21-10-23(30-24)20-9-19(20)21/h2-6,8,17,19-21,23-24,30H,7,9-10,12H2,1H3,(H,29,32)/t17-,19+,20-,21+,23-,24-/m0/s1 YVWVOYUBGOKFMC-VRTCABIXSA-N 150475 US10238633, Example 149::US8987249, 149::US9713606, 149 Dipeptidyl peptidase 1 38.7 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150475 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150475&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430573 252824726 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732551 CNS(=O)(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C24H25FN4O3S/c1-27-33(31,32)17-6-4-13(5-7-17)14-2-3-15(21(25)9-14)8-16(12-26)28-24(30)23-20-11-22(29-23)19-10-18(19)20/h2-7,9,16,18-20,22-23,27,29H,8,10-11H2,1H3,(H,28,30)/t16-,18+,19-,20+,22-,23-/m0/s1 UZSYZFPBBVJDMU-VUPWWPOFSA-N 150476 US10238633, Example 150::US8987249, 150::US9713606, 150 Dipeptidyl peptidase 1 38.6 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150476 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150476&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90440146 252824727 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732552 CCS(=O)(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3C[C@@H]2[C@@H]2C[C@H]32)C#N)c(F)c1 InChI=1S/C25H26FN3O3S/c1-2-33(31,32)18-7-5-14(6-8-18)15-3-4-16(22(26)10-15)9-17(13-27)28-25(30)24-21-12-23(29-24)20-11-19(20)21/h3-8,10,17,19-21,23-24,29H,2,9,11-12H2,1H3,(H,28,30)/t17-,19+,20-,21+,23-,24-/m0/s1 XTVUWKAUOSAVCH-VRTCABIXSA-N 150477 US10238633, Example 151::US8987249, 151::US9713606, 151 Dipeptidyl peptidase 1 36.9 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150477&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90440145 252824728 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732553 CS(=O)(=O)c1cc(ccc1F)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H23F2N3O3S/c1-32(30,31)21-11-14(5-7-19(21)24)13-2-3-15(20(25)10-13)8-18(12-26)28-23(29)22-16-4-6-17(9-16)27-22/h2-3,5,7,10-11,16-18,22,27H,4,6,8-9H2,1H3,(H,28,29)/t16-,17+,18-,22-/m0/s1 MQUCJSMVHXVYQA-SUWCGCSTSA-N 150478 US10238633, Example 152::US8987249, 152::US9713606, 152 Dipeptidyl peptidase 1 2.10 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150478 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150478&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430590 252824729 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732554 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cccc(c1)S(=O)(=O)C1CC1 InChI=1S/C25H26FN3O3S/c26-23-13-16(15-2-1-3-22(12-15)33(31,32)21-8-9-21)4-5-17(23)10-20(14-27)29-25(30)24-18-6-7-19(11-18)28-24/h1-5,12-13,18-21,24,28H,6-11H2,(H,29,30)/t18-,19+,20-,24-/m0/s1 OOGGADCCZJKURU-VKDGWMQASA-N 150479 US10238633, Example 153::US8987249, 153::US9713606, 153 Dipeptidyl peptidase 1 3.80 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150479&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430710 252824730 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732555 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCN(CC2CCCO2)CC1 InChI=1S/C25H34FN5O2/c26-23-14-21(31-9-7-30(8-10-31)16-22-2-1-11-33-22)6-4-17(23)12-20(15-27)29-25(32)24-18-3-5-19(13-18)28-24/h4,6,14,18-20,22,24,28H,1-3,5,7-13,16H2,(H,29,32)/t18-,19+,20-,22?,24-/m0/s1 NOJDRJVHLUWQDY-GTVKUMRUSA-N 150480 US10238633, Example 154::US8987249, 154 Dipeptidyl peptidase 1 13.5 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150480 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150480&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430763 252824731 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732556 CN1CCN(CC1)S(=O)(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C27H32FN5O3S/c1-32-10-12-33(13-11-32)37(35,36)24-8-5-18(6-9-24)19-2-3-20(25(28)16-19)14-23(17-29)31-27(34)26-21-4-7-22(15-21)30-26/h2-3,5-6,8-9,16,21-23,26,30H,4,7,10-15H2,1H3,(H,31,34)/t21-,22+,23-,26-/m0/s1 JTEJDGCXJPQUEE-LNEBKTTKSA-N 150481 US10238633, Example 155::US8987249, 155::US9713606, 155 Dipeptidyl peptidase 1 0.800 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150481 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150481&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430713 252824732 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732557 CC1(C)OC(=O)c2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C26H26FN3O3/c1-26(2)21-11-14(6-8-20(21)25(32)33-26)15-3-4-16(22(27)12-15)9-19(13-28)30-24(31)23-17-5-7-18(10-17)29-23/h3-4,6,8,11-12,17-19,23,29H,5,7,9-10H2,1-2H3,(H,30,31)/t17-,18+,19-,23-/m0/s1 JLXZFFFCLDPPDS-YWNPBTLJSA-N 150482 US10238633, Example 156::US8987249, 156::US9713606, 156 Dipeptidyl peptidase 1 0.600 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150482 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150482&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430711 252824733 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732558 NC(=O)c1cc(cs1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H21FN4O2S/c22-17-7-11(14-8-18(20(24)27)29-10-14)1-2-12(17)5-16(9-23)26-21(28)19-13-3-4-15(6-13)25-19/h1-2,7-8,10,13,15-16,19,25H,3-6H2,(H2,24,27)(H,26,28)/t13-,15+,16-,19-/m0/s1 PPGCNUWVAWUDDJ-YBKUAAOGSA-N 150483 US10238633, Example 157::US8987249, 157::US9713606, 157 Dipeptidyl peptidase 1 0.900 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150483&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430439 252824734 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732559 COCCN1C(=O)Cc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C27H29FN4O3/c1-35-9-8-32-24-13-17(3-5-19(24)14-25(32)33)16-2-4-18(23(28)12-16)10-22(15-29)31-27(34)26-20-6-7-21(11-20)30-26/h2-5,12-13,20-22,26,30H,6-11,14H2,1H3,(H,31,34)/t20-,21+,22-,26-/m0/s1 UCFPAQYLFQEDGE-MSZDEVHKSA-N 150484 US10238633, Example 158::US8987249, 158::US9713606, 158 Dipeptidyl peptidase 1 1.50 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150484&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430356 252824735 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732560 CS(=O)(=O)c1ccc(cc1C#N)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H23FN4O3S/c1-33(31,32)22-7-5-14(8-18(22)12-26)15-2-3-16(21(25)11-15)9-20(13-27)29-24(30)23-17-4-6-19(10-17)28-23/h2-3,5,7-8,11,17,19-20,23,28H,4,6,9-10H2,1H3,(H,29,30)/t17-,19+,20-,23-/m0/s1 ITRTUPJLHWDSML-USKVXJDGSA-N 150485 US10238633, Example 159::US8987249, 159::US9713606, 159 Dipeptidyl peptidase 1 1.60 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150485 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150485&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430392 252824736 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732561 Cc1nn(C)cc1-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H24FN5O/c1-12-18(11-27(2)26-12)13-3-4-14(19(22)9-13)7-17(10-23)25-21(28)20-15-5-6-16(8-15)24-20/h3-4,9,11,15-17,20,24H,5-8H2,1-2H3,(H,25,28)/t15-,16+,17-,20-/m0/s1 PJLDKVMJPLPBAC-CLWJZODNSA-N 150486 US10238633, Example 160::US8987249, 160::US9713606, 160 Dipeptidyl peptidase 1 1.70 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150486 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150486&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430385 252824737 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732562 CNC(=O)c1cc(cs1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H23FN4O2S/c1-25-21(28)19-9-15(11-30-19)12-2-3-13(18(23)8-12)6-17(10-24)27-22(29)20-14-4-5-16(7-14)26-20/h2-3,8-9,11,14,16-17,20,26H,4-7H2,1H3,(H,25,28)(H,27,29)/t14-,16+,17-,20-/m0/s1 XLNGTIPWUNYKLV-FORWCCJISA-N 150487 US10238633, Example 161::US8987249, 161::US9713606, 161 Dipeptidyl peptidase 1 1.90 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150487 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150487&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430393 252824738 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732563 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc(o1)C#N InChI=1S/C21H19FN4O2/c22-18-9-13(19-6-5-17(11-24)28-19)2-1-12(18)7-16(10-23)26-21(27)20-14-3-4-15(8-14)25-20/h1-2,5-6,9,14-16,20,25H,3-4,7-8H2,(H,26,27)/t14-,15+,16-,20-/m0/s1 MKOXMDMJBGUVAL-QOIOWGMHSA-N 150488 US10238633, Example 162::US8987249, 162::US9713606, 162 Dipeptidyl peptidase 1 2.00 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150488 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150488&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430754 252824739 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732564 Cn1cc(cn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C20H22FN5O/c1-26-11-15(10-23-26)12-2-3-13(18(21)8-12)6-17(9-22)25-20(27)19-14-4-5-16(7-14)24-19/h2-3,8,10-11,14,16-17,19,24H,4-7H2,1H3,(H,25,27)/t14-,16+,17-,19-/m0/s1 KPMQKTGWDITMBY-RUENVJTFSA-N 150489 US10238633, Example 163::US8987249, 163::US9713606, 163 Dipeptidyl peptidase 1 2.10 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150489 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150489&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430794 252824740 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732565 CCCNC(=O)c1cc(cs1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H27FN4O2S/c1-2-7-27-23(30)21-11-17(13-32-21)14-3-4-15(20(25)10-14)8-19(12-26)29-24(31)22-16-5-6-18(9-16)28-22/h3-4,10-11,13,16,18-19,22,28H,2,5-9H2,1H3,(H,27,30)(H,29,31)/t16-,18+,19-,22-/m0/s1 YDADTGZYWBWBFN-ZBPHCFQXSA-N 150490 US10238633, Example 164::US8987249, 164::US9713606, 164 Dipeptidyl peptidase 1 2.30 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150490 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150490&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430864 252824741 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732566 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1csc(c1)C(=O)N1CCCC1 InChI=1S/C25H27FN4O2S/c26-21-11-15(18-12-22(33-14-18)25(32)30-7-1-2-8-30)3-4-16(21)9-20(13-27)29-24(31)23-17-5-6-19(10-17)28-23/h3-4,11-12,14,17,19-20,23,28H,1-2,5-10H2,(H,29,31)/t17-,19+,20-,23-/m0/s1 LDCGUTCTCPBDJA-USKVXJDGSA-N 150491 US10238633, Example 165::US8987249, 165::US9713606, 165 Dipeptidyl peptidase 1 2.70 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150491 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150491&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430758 252824742 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732567 CC1(C)OC(=O)c2cc(ccc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C26H26FN3O3/c1-26(2)21-8-6-14(11-20(21)25(32)33-26)15-3-4-16(22(27)12-15)9-19(13-28)30-24(31)23-17-5-7-18(10-17)29-23/h3-4,6,8,11-12,17-19,23,29H,5,7,9-10H2,1-2H3,(H,30,31)/t17-,18+,19-,23-/m0/s1 OAJPZRYTQVCUSS-YWNPBTLJSA-N 150492 US10238633, Example 166::US8987249, 166::US9713606, 166 Dipeptidyl peptidase 1 3.30 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150492 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150492&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430865 252824743 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732568 NC(=O)c1ccc(o1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H21FN4O3/c22-16-9-12(17-5-6-18(29-17)20(24)27)2-1-11(16)7-15(10-23)26-21(28)19-13-3-4-14(8-13)25-19/h1-2,5-6,9,13-15,19,25H,3-4,7-8H2,(H2,24,27)(H,26,28)/t13-,14+,15-,19-/m0/s1 QWPJDKJCATZPMT-YGTYGHESSA-N 150493 US10238633, Example 167::US8987249, 167::US9713606, 167 Dipeptidyl peptidase 1 3.40 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150493 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150493&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430248 252824744 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732569 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnn2cccnc12 InChI=1S/C22H21FN6O/c23-19-10-13(18-12-26-29-7-1-6-25-21(18)29)2-3-14(19)8-17(11-24)28-22(30)20-15-4-5-16(9-15)27-20/h1-3,6-7,10,12,15-17,20,27H,4-5,8-9H2,(H,28,30)/t15-,16+,17-,20-/m0/s1 UAJICJMQOYRRAS-CLWJZODNSA-N 150494 US10238633, Example 168::US8987249, 168::US9713606, 168 Dipeptidyl peptidase 1 3.70 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150494 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150494&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430249 252824745 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732570 CN1Cc2cc(ccc2S1(=O)=O)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H25FN4O3S/c1-29-13-18-8-14(5-7-22(18)33(29,31)32)15-2-3-16(21(25)11-15)9-20(12-26)28-24(30)23-17-4-6-19(10-17)27-23/h2-3,5,7-8,11,17,19-20,23,27H,4,6,9-10,13H2,1H3,(H,28,30)/t17-,19+,20-,23-/m0/s1 LHDHATUHLZCALX-USKVXJDGSA-N 150495 US10238633, Example 169::US8987249, 169::US9713606, 169 Dipeptidyl peptidase 1 4.10 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150495&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430258 252824746 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732571 CN(C)C(=O)c1cc(cs1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H25FN4O2S/c1-28(2)23(30)20-10-16(12-31-20)13-3-4-14(19(24)9-13)7-18(11-25)27-22(29)21-15-5-6-17(8-15)26-21/h3-4,9-10,12,15,17-18,21,26H,5-8H2,1-2H3,(H,27,29)/t15-,17+,18-,21-/m0/s1 BMZNBIDFQPNVPA-DKXUYOFUSA-N 150496 US10238633, Example 170::US8987249, 170::US9713606, 170 Dipeptidyl peptidase 1 4.20 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150496&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430265 252824747 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732572 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnn(c1)-c1ccccc1 InChI=1S/C25H24FN5O/c26-23-12-16(19-14-28-31(15-19)22-4-2-1-3-5-22)6-7-17(23)10-21(13-27)30-25(32)24-18-8-9-20(11-18)29-24/h1-7,12,14-15,18,20-21,24,29H,8-11H2,(H,30,32)/t18-,20+,21-,24-/m0/s1 DMZSQOLHWTVSKK-UQWVPHONSA-N 150497 US10238633, Example 171::US8987249, 171::US9713606, 171 Dipeptidyl peptidase 1 5.00 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150497&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430257 252824748 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732573 CCOc1nc(cs1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H23FN4O2S/c1-2-28-21-26-18(11-29-21)13-4-3-12(17(22)9-13)7-16(10-23)25-20(27)19-14-5-6-15(8-14)24-19/h3-4,9,11,14-16,19,24H,2,5-8H2,1H3,(H,25,27)/t14-,15+,16-,19-/m0/s1 IWTOEPXDCLKGJZ-RCJHGTSTSA-N 150498 US10238633, Example 172::US8987249, 172::US9713606, 172 Dipeptidyl peptidase 1 5.20 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150498 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150498&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937196 252824749 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732574 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnc(s1)C1CC1 InChI=1S/C22H23FN4OS/c23-18-9-14(19-11-25-22(29-19)12-1-2-12)4-3-13(18)7-17(10-24)27-21(28)20-15-5-6-16(8-15)26-20/h3-4,9,11-12,15-17,20,26H,1-2,5-8H2,(H,27,28)/t15-,16+,17-,20-/m0/s1 UHFZBONSCYKOGY-CLWJZODNSA-N 150499 US10238633, Example 173::US8987249, 173::US9713606, 173 Dipeptidyl peptidase 1 5.50 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150499&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430637 252824750 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732575 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnc2cccnn12 InChI=1S/C22H21FN6O/c23-18-10-14(19-12-25-20-2-1-7-26-29(19)20)4-3-13(18)8-17(11-24)28-22(30)21-15-5-6-16(9-15)27-21/h1-4,7,10,12,15-17,21,27H,5-6,8-9H2,(H,28,30)/t15-,16+,17-,21-/m0/s1 CCYSIWWCGWSLDL-DLRJPAPCSA-N 150500 US10238633, Example 174::US8987249, 174::US9713606, 174 Dipeptidyl peptidase 1 5.60 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150500&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430822 252824751 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732576 COC(=O)c1ccc(o1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H22FN3O4/c1-29-22(28)19-7-6-18(30-19)13-3-2-12(17(23)10-13)8-16(11-24)26-21(27)20-14-4-5-15(9-14)25-20/h2-3,6-7,10,14-16,20,25H,4-5,8-9H2,1H3,(H,26,27)/t14-,15+,16-,20-/m0/s1 DOSFIFURJGVDGZ-QOIOWGMHSA-N 150501 US10238633, Example 175::US8987249, 175::US9713606, 175 Dipeptidyl peptidase 1 6.30 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150501&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937197 252824752 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732577 CS(=O)(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1F InChI=1S/C23H23F2N3O3S/c1-32(30,31)18-7-3-13(4-8-18)19-9-5-14(20(24)21(19)25)10-17(12-26)28-23(29)22-15-2-6-16(11-15)27-22/h3-5,7-9,15-17,22,27H,2,6,10-11H2,1H3,(H,28,29)/t15-,16+,17-,22-/m0/s1 HFCMZDPZCZIGCP-GEYWLOKFSA-N 150502 US10238633, Example 176::US8987249, 176::US9713606, 176 Dipeptidyl peptidase 1 6.60 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150502&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430823 252824753 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732578 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc(cc1)S(=O)(=O)N1CCCCC1 InChI=1S/C27H31FN4O3S/c28-25-16-19(18-7-10-24(11-8-18)36(34,35)32-12-2-1-3-13-32)4-5-20(25)14-23(17-29)31-27(33)26-21-6-9-22(15-21)30-26/h4-5,7-8,10-11,16,21-23,26,30H,1-3,6,9,12-15H2,(H,31,33)/t21-,22+,23-,26-/m0/s1 QDYXJVMXCAOXIV-LNEBKTTKSA-N 150503 US10238633, Example 177::US8987249, 177::US9713606, 177 Dipeptidyl peptidase 1 7.40 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150503 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150503&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430824 252824754 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732579 COCCN1CCN(CC1C)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H34FN5O2/c1-16-15-30(8-7-29(16)9-10-32-2)21-6-4-17(22(25)13-21)11-20(14-26)28-24(31)23-18-3-5-19(12-18)27-23/h4,6,13,16,18-20,23,27H,3,5,7-12,15H2,1-2H3,(H,28,31)/t16?,18-,19+,20-,23-/m0/s1 OEWFJFIVDPBLOL-XPNKYNLISA-N 150504 US10238633, Example 178::US8987249, 178::US9713606, 178 Dipeptidyl peptidase 1 7.40 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150504&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443245 252824755 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732580 CCOC(=O)c1ccc(s1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H24FN3O3S/c1-2-30-23(29)20-8-7-19(31-20)14-4-3-13(18(24)11-14)9-17(12-25)27-22(28)21-15-5-6-16(10-15)26-21/h3-4,7-8,11,15-17,21,26H,2,5-6,9-10H2,1H3,(H,27,28)/t15-,16+,17-,21-/m0/s1 UYZWDKFSNQPGHZ-DLRJPAPCSA-N 150505 US10238633, Example 179::US8987249, 179::US9713606, 179 Dipeptidyl peptidase 1 7.50 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150505 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150505&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90440149 252824756 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732581 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-n1cccn1 InChI=1S/C19H20FN5O/c20-17-10-16(25-7-1-6-22-25)5-3-12(17)8-15(11-21)24-19(26)18-13-2-4-14(9-13)23-18/h1,3,5-7,10,13-15,18,23H,2,4,8-9H2,(H,24,26)/t13-,14+,15-,18-/m0/s1 YFJMUZCPWDVHKP-KRXQYRFLSA-N 150506 US10238633, Example 180::US8987249, 180::US9713606, 180 Dipeptidyl peptidase 1 7.70 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150506 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150506&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430716 252824757 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732582 Fc1c(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)ccc(c1F)-c1ccc2CC(=O)Nc2c1 InChI=1S/C24H22F2N4O2/c25-21-14(7-17(11-27)29-24(32)23-15-3-5-16(8-15)28-23)4-6-18(22(21)26)12-1-2-13-10-20(31)30-19(13)9-12/h1-2,4,6,9,15-17,23,28H,3,5,7-8,10H2,(H,29,32)(H,30,31)/t15-,16+,17-,23-/m0/s1 GZBOPPMZTWXCEG-IPPNXFFKSA-N 150507 US10238633, Example 181::US8987249, 181::US9713606, 181 Dipeptidyl peptidase 1 8.60 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150507 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150507&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443264 252824758 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732583 COCCN1CCN(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H32FN5O2/c1-31-11-10-28-6-8-29(9-7-28)20-5-3-16(21(24)14-20)12-19(15-25)27-23(30)22-17-2-4-18(13-17)26-22/h3,5,14,17-19,22,26H,2,4,6-13H2,1H3,(H,27,30)/t17-,18+,19-,22-/m0/s1 SACZOVLAILIBSM-WEMPKCCASA-N 150508 US10238633, Example 182::US8987249, 182::US9713606, 182 Dipeptidyl peptidase 1 8.80 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150508 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150508&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443246 252824759 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732584 CS(=O)(=O)c1cc(ccc1C#N)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1F InChI=1S/C24H22F2N4O3S/c1-34(32,33)20-10-13(2-3-16(20)11-27)19-7-5-14(21(25)22(19)26)8-18(12-28)30-24(31)23-15-4-6-17(9-15)29-23/h2-3,5,7,10,15,17-18,23,29H,4,6,8-9H2,1H3,(H,30,31)/t15-,17+,18-,23-/m0/s1 BHOUHJMWXTTXMV-XITLKHQFSA-N 150509 US10238633, Example 183::US8987249, 183::US9713606, 183 Dipeptidyl peptidase 1 8.80 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150509 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150509&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430803 252824760 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732585 CCNC(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C25H27FN4O2/c1-2-28-24(31)16-5-3-15(4-6-16)17-7-8-18(22(26)13-17)11-21(14-27)30-25(32)23-19-9-10-20(12-19)29-23/h3-8,13,19-21,23,29H,2,9-12H2,1H3,(H,28,31)(H,30,32)/t19-,20+,21-,23-/m0/s1 QONINOVIALYSKY-KGSLCBSSSA-N 150510 US10238633, Example 184::US8987249, 184::US9713606, 184 Dipeptidyl peptidase 1 8.80 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150510 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150510&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430780 252824761 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732586 CN1CCN(CC1)C(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C28H32FN5O2/c1-33-10-12-34(13-11-33)28(36)19-4-2-18(3-5-19)20-6-7-21(25(29)16-20)14-24(17-30)32-27(35)26-22-8-9-23(15-22)31-26/h2-7,16,22-24,26,31H,8-15H2,1H3,(H,32,35)/t22-,23+,24-,26-/m0/s1 BCTCYNYSBOFOGS-UHCVVMIDSA-N 150511 US10238633, Example 185::US8987249, 185::US9713606, 185 Dipeptidyl peptidase 1 9.00 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150511 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150511&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443251 252824762 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732587 CNC(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H25FN4O2/c1-27-23(30)15-4-2-14(3-5-15)16-6-7-17(21(25)12-16)10-20(13-26)29-24(31)22-18-8-9-19(11-18)28-22/h2-7,12,18-20,22,28H,8-11H2,1H3,(H,27,30)(H,29,31)/t18-,19+,20-,22-/m0/s1 LNYQNVOBORIQSU-IIZPIQPGSA-N 150512 US10238633, Example 186::US8987249, 186::US9713606, 186 Dipeptidyl peptidase 1 9.60 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150512 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150512&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443253 252824763 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732588 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCN(CC1)C1CC1 InChI=1S/C23H30FN5O/c24-21-13-20(29-9-7-28(8-10-29)19-5-6-19)4-2-15(21)11-18(14-25)27-23(30)22-16-1-3-17(12-16)26-22/h2,4,13,16-19,22,26H,1,3,5-12H2,(H,27,30)/t16-,17+,18-,22-/m0/s1 KRGWGKDDVUPCTC-SUWCGCSTSA-N 150513 US10238633, Example 187::US8987249, 187::US9713606, 187 Dipeptidyl peptidase 1 9.80 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150513 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150513&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430775 252824764 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732589 C[C@H]1CN(C)CCN1c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H30FN5O/c1-14-13-27(2)7-8-28(14)19-6-4-15(20(23)11-19)9-18(12-24)26-22(29)21-16-3-5-17(10-16)25-21/h4,6,11,14,16-18,21,25H,3,5,7-10,13H2,1-2H3,(H,26,29)/t14-,16-,17+,18-,21-/m0/s1 PITCSQNCAUTIHO-ODKKXURNSA-N 150514 US10238633, Example 188::US8987249, 188::US9713606, 188 Dipeptidyl peptidase 1 9.80 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150514&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430776 252824765 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732590 Fc1cc(OCCN2CCNCC2)ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N InChI=1S/C22H30FN5O2/c23-20-13-19(30-10-9-28-7-5-25-6-8-28)4-2-15(20)11-18(14-24)27-22(29)21-16-1-3-17(12-16)26-21/h2,4,13,16-18,21,25-26H,1,3,5-12H2,(H,27,29)/t16-,17+,18-,21-/m0/s1 DYZTZKMZXIOJOY-NYUBLWNDSA-N 150515 US10238633, Example 189::US8987249, 189::US9713606, 189 Dipeptidyl peptidase 1 10.4 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150515&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430777 252824766 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732591 OCCN1CCN(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H30FN5O2/c23-20-13-19(28-7-5-27(6-8-28)9-10-29)4-2-15(20)11-18(14-24)26-22(30)21-16-1-3-17(12-16)25-21/h2,4,13,16-18,21,25,29H,1,3,5-12H2,(H,26,30)/t16-,17+,18-,21-/m0/s1 JYCKJIYGTBLGHE-NYUBLWNDSA-N 150516 US10238633, Example 190::US8987249, 190::US9713606, 190 Dipeptidyl peptidase 1 10.9 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150516 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150516&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430846 252824767 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732592 COCCN1C(C)CN(CC1C)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C25H36FN5O2/c1-16-14-30(15-17(2)31(16)8-9-33-3)22-7-5-18(23(26)12-22)10-21(13-27)29-25(32)24-19-4-6-20(11-19)28-24/h5,7,12,16-17,19-21,24,28H,4,6,8-11,14-15H2,1-3H3,(H,29,32)/t16?,17?,19-,20+,21-,24-/m0/s1 KNULSPGFBWAFEV-QAGFWZOLSA-N 150517 US10238633, Example 191::US8987249, 191::US9713606, 191 Dipeptidyl peptidase 1 11.2 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150517 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150517&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430872 252824768 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732593 CC1CN(C)CCN1c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H30FN5O/c1-14-13-27(2)7-8-28(14)19-6-4-15(20(23)11-19)9-18(12-24)26-22(29)21-16-3-5-17(10-16)25-21/h4,6,11,14,16-18,21,25H,3,5,7-10,13H2,1-2H3,(H,26,29)/t14?,16-,17+,18-,21-/m0/s1 PITCSQNCAUTIHO-PGKCESFNSA-N 150518 US10238633, Example 192::US8987249, 192::US9713606, 192 Dipeptidyl peptidase 1 11.3 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150518 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150518&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430873 252824769 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732594 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCC(CC1)N1CCOCC1 InChI=1S/C25H34FN5O2/c26-23-15-22(30-7-5-21(6-8-30)31-9-11-33-12-10-31)4-2-17(23)13-20(16-27)29-25(32)24-18-1-3-19(14-18)28-24/h2,4,15,18-21,24,28H,1,3,5-14H2,(H,29,32)/t18-,19+,20-,24-/m0/s1 JABMZGKUYITGQO-VKDGWMQASA-N 150519 US10238633, Example 193::US8987249, 193::US9713606, 193 Dipeptidyl peptidase 1 12.3 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150519 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150519&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430847 252824770 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732595 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnc2cnccn12 InChI=1S/C22H21FN6O/c23-18-9-14(19-11-26-20-12-25-5-6-29(19)20)2-1-13(18)7-17(10-24)28-22(30)21-15-3-4-16(8-15)27-21/h1-2,5-6,9,11-12,15-17,21,27H,3-4,7-8H2,(H,28,30)/t15-,16+,17-,21-/m0/s1 DLTNLHDASBIQQA-DLRJPAPCSA-N 150520 US10238633, Example 194::US8987249, 194::US9713606, 194 Dipeptidyl peptidase 1 13.3 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150520 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150520&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430813 252824771 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732596 CC1(C)CCN(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H31FN4O/c1-23(2)7-9-28(10-8-23)19-6-4-15(20(24)13-19)11-18(14-25)27-22(29)21-16-3-5-17(12-16)26-21/h4,6,13,16-18,21,26H,3,5,7-12H2,1-2H3,(H,27,29)/t16-,17+,18-,21-/m0/s1 BXFGDWVBWBYTHB-NYUBLWNDSA-N 150521 US10238633, Example 195::US8987249, 195::US9713606, 195 Dipeptidyl peptidase 1 14.7 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150521&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443244 252824772 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732597 CC1CN(C(C)CN1C)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H32FN5O/c1-14-13-29(15(2)12-28(14)3)20-7-5-16(21(24)10-20)8-19(11-25)27-23(30)22-17-4-6-18(9-17)26-22/h5,7,10,14-15,17-19,22,26H,4,6,8-9,12-13H2,1-3H3,(H,27,30)/t14?,15?,17-,18+,19-,22-/m0/s1 HJMOTVPNQZUZFS-MHRVTNIKSA-N 150522 US10238633, Example 196::US8987249, 196::US9713606, 196 Dipeptidyl peptidase 1 15.1 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150522 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150522&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443160 252824773 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732598 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCCCC1 InChI=1S/C21H27FN4O/c22-19-12-18(26-8-2-1-3-9-26)7-5-14(19)10-17(13-23)25-21(27)20-15-4-6-16(11-15)24-20/h5,7,12,15-17,20,24H,1-4,6,8-11H2,(H,25,27)/t15-,16+,17-,20-/m0/s1 NAECJPAQRDJHFX-CLWJZODNSA-N 150523 US10238633, Example 197::US8987249, 197::US9713606, 197 Dipeptidyl peptidase 1 15.6 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150523 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150523&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430381 252824774 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732599 COC(=O)c1cc(C)c(s1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H24FN3O3S/c1-12-7-19(23(29)30-2)31-21(12)15-4-3-13(18(24)10-15)8-17(11-25)27-22(28)20-14-5-6-16(9-14)26-20/h3-4,7,10,14,16-17,20,26H,5-6,8-9H2,1-2H3,(H,27,28)/t14-,16+,17-,20-/m0/s1 TWRCTBLMEJQQQC-FORWCCJISA-N 150524 US10238633, Example 198::US8987249, 198::US9713606, 198 Dipeptidyl peptidase 1 15.8 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150524 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150524&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430382 252824775 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732600 CN1C(=O)C(C)(C)c2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C27H29FN4O2/c1-27(2)21-9-7-16(13-23(21)32(3)26(27)34)15-4-5-17(22(28)12-15)10-20(14-29)31-25(33)24-18-6-8-19(11-18)30-24/h4-5,7,9,12-13,18-20,24,30H,6,8,10-11H2,1-3H3,(H,31,33)/t18-,19+,20-,24-/m0/s1 BDKPRFCKGSLJAZ-VKDGWMQASA-N 150525 US10238633, Example 199::US8987249, 199::US9713606, 199 Dipeptidyl peptidase 1 16.0 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150525 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150525&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443273 252824776 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732601 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc(cc1)C(=O)NC1CCOCC1 InChI=1S/C28H31FN4O3/c29-25-15-19(17-1-3-18(4-2-17)27(34)32-22-9-11-36-12-10-22)5-6-20(25)13-24(16-30)33-28(35)26-21-7-8-23(14-21)31-26/h1-6,15,21-24,26,31H,7-14H2,(H,32,34)(H,33,35)/t21-,23+,24-,26-/m0/s1 YVIQKIOIKPSZTK-YUZJIJRXSA-N 150526 US10238633, Example 200::US8987249, 200::US9713606, 200 Dipeptidyl peptidase 1 16.5 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150526&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430342 252824777 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732602 CCN1CCC(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H31FN4O/c1-2-28-9-7-15(8-10-28)16-3-4-17(21(24)13-16)11-20(14-25)27-23(29)22-18-5-6-19(12-18)26-22/h3-4,13,15,18-20,22,26H,2,5-12H2,1H3,(H,27,29)/t18-,19+,20-,22-/m0/s1 KZEDFSYJDOOQDK-IIZPIQPGSA-N 150527 US10238633, Example 201::US8987249, 201::US9713606, 201 Dipeptidyl peptidase 1 20.1 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150527 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150527&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430343 252824778 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732603 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc(cc1)C(=O)N1CCOCC1 InChI=1S/C27H29FN4O3/c28-24-15-19(17-1-3-18(4-2-17)27(34)32-9-11-35-12-10-32)5-6-20(24)13-23(16-29)31-26(33)25-21-7-8-22(14-21)30-25/h1-6,15,21-23,25,30H,7-14H2,(H,31,33)/t21-,22+,23-,25-/m0/s1 KFKUTDHWQWJWKQ-AANQFLQQSA-N 150528 US10238633, Example 202::US8987249, 202::US9713606, 202 Dipeptidyl peptidase 1 22.9 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150528&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430344 252824779 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732604 O=C(NC(Cc1ccc2c(c1)[nH]c1ccccc21)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 150529 US10238633, Example 203::US8987249, 203::US9713606, 203 Dipeptidyl peptidase 1 23.3 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150529 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150529&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430597 252824780 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732605 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCNCC1 InChI=1S/C20H26FN5O/c21-18-11-17(26-7-5-23-6-8-26)4-2-13(18)9-16(12-22)25-20(27)19-14-1-3-15(10-14)24-19/h2,4,11,14-16,19,23-24H,1,3,5-10H2,(H,25,27)/t14-,15+,16-,19-/m0/s1 IMHSIFFWUGPDKM-RCJHGTSTSA-N 150530 BDBM150661::US10238633, Example 335::US8987249, 204::US9713606, 335 Dipeptidyl peptidase 1 24.5 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150530&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430619 252824781 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732606 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCOCC1 InChI=1S/C20H25FN4O2/c21-18-11-17(25-5-7-27-8-6-25)4-2-13(18)9-16(12-22)24-20(26)19-14-1-3-15(10-14)23-19/h2,4,11,14-16,19,23H,1,3,5-10H2,(H,24,26)/t14-,15+,16-,19-/m0/s1 ZYYSFTGHYITWSH-RCJHGTSTSA-N 150531 US10238633, Example 205::US8987249, 205::US9713606, 205 Dipeptidyl peptidase 1 25.9 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150531&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430744 252824782 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732607 Cn1c2ccccc2c2ccc(CC(NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)cc2c1=O InChI=1S/C24H24N4O2/c1-28-21-5-3-2-4-19(21)18-9-6-14(11-20(18)24(28)30)10-17(13-25)27-23(29)22-15-7-8-16(12-15)26-22/h2-6,9,11,15-17,22,26H,7-8,10,12H2,1H3,(H,27,29)/t15-,16+,17?,22-/m0/s1 WCVYQAOROBFJTQ-GDLIHOIBSA-N 150532 US10238633, Example 206::US8987249, 206::US9713606, 206 Dipeptidyl peptidase 1 26.3 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150532&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430402 252824783 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732608 Fc1ccc2c3ccc(CC(NC(=O)[C@H]4N[C@@H]5CC[C@H]4C5)C#N)cc3[nH]c(=O)c2c1 150533 US10238633, Example 207::US8987249, 207::US9713606, 207 Dipeptidyl peptidase 1 29.1 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150533&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937198 252824784 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732609 Cc1cn(C)c(n1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H24FN5O/c1-12-11-27(2)20(24-12)15-4-3-13(18(22)9-15)7-17(10-23)26-21(28)19-14-5-6-16(8-14)25-19/h3-4,9,11,14,16-17,19,25H,5-8H2,1-2H3,(H,26,28)/t14-,16+,17-,19-/m0/s1 GJGNZYPJMSRJNR-RUENVJTFSA-N 150534 US10238633, Example 208::US8987249, 208::US9713606, 208 Dipeptidyl peptidase 1 29.8 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150534&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430591 252824785 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732610 O=C(NC(Cc1ccc-2c(CCc3ccccc-23)c1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C24H25N3O/c25-14-20(27-24(28)23-18-8-9-19(13-18)26-23)12-15-5-10-22-17(11-15)7-6-16-3-1-2-4-21(16)22/h1-5,10-11,18-20,23,26H,6-9,12-13H2,(H,27,28)/t18-,19+,20?,23-/m0/s1 LBTNQDABYUUSSI-SRDOODBNSA-N 150535 US10238633, Example 209::US8987249, 209::US9713606, 209 Dipeptidyl peptidase 1 45.8 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150535&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430574 252824786 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732611 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc(cc1)C(=O)N1CCCCC1 InChI=1S/C28H31FN4O2/c29-25-16-20(18-4-6-19(7-5-18)28(35)33-12-2-1-3-13-33)8-9-21(25)14-24(17-30)32-27(34)26-22-10-11-23(15-22)31-26/h4-9,16,22-24,26,31H,1-3,10-15H2,(H,32,34)/t22-,23+,24-,26-/m0/s1 ZBKBAEOLQSSJOG-UHCVVMIDSA-N 150536 US10238633, Example 210::US8987249, 210::US9713606, 210 Dipeptidyl peptidase 1 49.4 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150536 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150536&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443249 252824787 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732612 CN(C)C(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C25H27FN4O2/c1-30(2)25(32)16-5-3-15(4-6-16)17-7-8-18(22(26)13-17)11-21(14-27)29-24(31)23-19-9-10-20(12-19)28-23/h3-8,13,19-21,23,28H,9-12H2,1-2H3,(H,29,31)/t19-,20+,21-,23-/m0/s1 KMGXMFJKQCFWPN-KGSLCBSSSA-N 150537 US10238633, Example 211::US8987249, 211::US9713606, 211 Dipeptidyl peptidase 1 61.1 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150537 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150537&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430595 252824788 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732613 O=C(NC(Cc1ccc2oc3ccccc3c2c1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C22H21N3O2/c23-12-16(25-22(26)21-14-6-7-15(11-14)24-21)9-13-5-8-20-18(10-13)17-3-1-2-4-19(17)27-20/h1-5,8,10,14-16,21,24H,6-7,9,11H2,(H,25,26)/t14-,15+,16?,21-/m0/s1 AMDWUZAQDYEPGE-DAGLJCOKSA-N 150538 US10238633, Example 212::US8987249, 212::US9713606, 212 Dipeptidyl peptidase 1 296 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150538 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150538&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430552 252824789 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732614 O=C(NC(Cc1ccc2[nH]c3ccccc3c2c1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 150539 US10238633, Example 213::US8987249, 213::US9713606, 213 Dipeptidyl peptidase 1 619 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150539 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150539&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430560 252824790 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732615 CS(=O)(=O)c1cc(ccc1C#N)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3CC[C@@H]2C3)C#N)c(F)c1 InChI=1S/C24H23FN4O3S/c1-33(31,32)22-11-15(3-5-18(22)12-26)14-2-4-16(21(25)10-14)8-20(13-27)29-24(30)23-17-6-7-19(9-17)28-23/h2-5,10-11,17,19-20,23,28H,6-9H2,1H3,(H,29,30)/t17-,19+,20+,23+/m1/s1 AUHJWFLPELHPMB-UYOCQKMUSA-N 150540 US10238633, Example 214::US8987249, 214::US9713606, 214 Dipeptidyl peptidase 1 815 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150540 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150540&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430534 252824791 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732616 Fc1ccc2c(c1)c(=O)[nH]c1cccc(CC(NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)c21 150541 US10238633, Example 215::US8987249, 215::US9713606, 215 Dipeptidyl peptidase 1 882 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150541 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150541&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937199 252824792 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732617 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc(cc1)S(=O)(=O)N1CCOCC1 InChI=1S/C26H29FN4O4S/c27-24-15-18(17-4-7-23(8-5-17)36(33,34)31-9-11-35-12-10-31)1-2-19(24)13-22(16-28)30-26(32)25-20-3-6-21(14-20)29-25/h1-2,4-5,7-8,15,20-22,25,29H,3,6,9-14H2,(H,30,32)/t20-,21+,22-,25-/m0/s1 JKOMQLYGPOVMIW-MTQWNXOMSA-N 150543 BDBM263789::US10238633, Example 217::US8987249, 217 Dipeptidyl peptidase 1 3.70 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150543 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150543&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443250 252824794 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732618 Fc1c(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)ccc(-c2cnn(CC3CCOCC3)c2)c1F InChI=1S/C25H29F2N5O2/c26-22-16(9-20(11-28)31-25(33)24-17-1-3-19(10-17)30-24)2-4-21(23(22)27)18-12-29-32(14-18)13-15-5-7-34-8-6-15/h2,4,12,14-15,17,19-20,24,30H,1,3,5-10,13H2,(H,31,33)/t17-,19+,20-,24-/m0/s1 YMORABQOPNMDEV-GHCZAOPSSA-N 150544 US10238633, Example 218::US8987249, 218::US9713606, 218 Dipeptidyl peptidase 1 18.9 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150544 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150544&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430698 252824795 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732619 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)C1CCN(Cc2ccccc2)CC1 InChI=1S/C28H33FN4O/c29-26-16-21(20-10-12-33(13-11-20)18-19-4-2-1-3-5-19)6-7-22(26)14-25(17-30)32-28(34)27-23-8-9-24(15-23)31-27/h1-7,16,20,23-25,27,31H,8-15,18H2,(H,32,34)/t23-,24+,25-,27-/m0/s1 SQFBEZWDNANXIK-SFIUMABJSA-N 150545 US10238633, Example 219::US8987249, 219::US9713606, 219 Dipeptidyl peptidase 1 37.4 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150545 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150545&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443270 252824796 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732620 O=C(N[C@@H](Cc1ccc2ccccc2c1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C20H21N3O/c21-12-18(23-20(24)19-16-7-8-17(11-16)22-19)10-13-5-6-14-3-1-2-4-15(14)9-13/h1-6,9,16-19,22H,7-8,10-11H2,(H,23,24)/t16-,17+,18-,19-/m0/s1 FNUIDHMDMWFOTD-RDGPPVDQSA-N 150546 US10238633, Example 220::US8987249, 220::US9713606, 220 Dipeptidyl peptidase 1 253 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150546 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150546&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430616 252824797 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732621 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnc2CCCn12 InChI=1S/C22H24FN5O/c23-18-10-14(19-12-25-20-2-1-7-28(19)20)4-3-13(18)8-17(11-24)27-22(29)21-15-5-6-16(9-15)26-21/h3-4,10,12,15-17,21,26H,1-2,5-9H2,(H,27,29)/t15-,16+,17-,21-/m0/s1 IJYAQVSCUDSUGF-DLRJPAPCSA-N 150547 US10238633, Example 221::US8987249, 221::US9713606, 221 Dipeptidyl peptidase 1 3.70 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150547 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150547&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430621 252824798 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732622 CS(=O)(=NC#N)c1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H24FN5O2S/c1-33(32,28-14-27)21-4-2-3-15(11-21)16-5-6-17(22(25)12-16)9-20(13-26)30-24(31)23-18-7-8-19(10-18)29-23/h2-6,11-12,18-20,23,29H,7-10H2,1H3,(H,30,31)/t18-,19+,20-,23-,33?/m0/s1 LPAPVHRQNZAJHB-PVEGDPQMSA-N 150548 US10238633, Example 222::US8987249, 222::US9713606, 222 Dipeptidyl peptidase 1 2.20 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150548 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150548&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443276 252824799 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732623 CN1CCC(=CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H27FN4O/c1-27-8-6-14(7-9-27)15-2-3-16(20(23)12-15)10-19(13-24)26-22(28)21-17-4-5-18(11-17)25-21/h2-3,6,12,17-19,21,25H,4-5,7-11H2,1H3,(H,26,28)/t17-,18+,19-,21-/m0/s1 YQARVKLTMMGHQQ-JTJHWIPRSA-N 150549 US10238633, Example 223::US8987249, 223::US9713606, 223 Dipeptidyl peptidase 1 5.90 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150549 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150549&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430440 252824800 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732624 CN1CCN(CC1)S(=O)(=O)c1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C27H32FN5O3S/c1-32-9-11-33(12-10-32)37(35,36)24-4-2-3-18(15-24)19-5-6-20(25(28)16-19)13-23(17-29)31-27(34)26-21-7-8-22(14-21)30-26/h2-6,15-16,21-23,26,30H,7-14H2,1H3,(H,31,34)/t21-,22+,23-,26-/m0/s1 BCGCLCVNTALUEW-LNEBKTTKSA-N 150550 US10238633, Example 224::US8987249, 224::US9713606, 224 Dipeptidyl peptidase 1 1.20 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150550 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150550&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430441 252824801 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732625 CN1CCN(CC1)C(=O)c1cc(cs1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C26H30FN5O2S/c1-31-6-8-32(9-7-31)26(34)23-13-19(15-35-23)16-2-3-17(22(27)12-16)10-21(14-28)30-25(33)24-18-4-5-20(11-18)29-24/h2-3,12-13,15,18,20-21,24,29H,4-11H2,1H3,(H,30,33)/t18-,20+,21-,24-/m0/s1 NGMZWVPZCPOOFW-UQWVPHONSA-N 150551 US10238633, Example 225::US8987249, 225::US9713606, 225 Dipeptidyl peptidase 1 0.800 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150551 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150551&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443275 252824802 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732626 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1csc(c1)C(=O)N1CCn2nccc2C1 InChI=1S/C27H27FN6O2S/c28-23-11-16(19-12-24(37-15-19)27(36)33-7-8-34-22(14-33)5-6-30-34)1-2-17(23)9-21(13-29)32-26(35)25-18-3-4-20(10-18)31-25/h1-2,5-6,11-12,15,18,20-21,25,31H,3-4,7-10,14H2,(H,32,35)/t18-,20+,21-,25-/m0/s1 YQNUZNHUSHDGSJ-HOSCZWGSSA-N 150552 US10238633, Example 226::US8987249, 226::US9713606, 226 Dipeptidyl peptidase 1 0.900 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150552&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443271 252824803 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732627 CC(C)N1CCN(CC1)C(=O)c1cc(cs1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C28H34FN5O2S/c1-17(2)33-7-9-34(10-8-33)28(36)25-14-21(16-37-25)18-3-4-19(24(29)13-18)11-23(15-30)32-27(35)26-20-5-6-22(12-20)31-26/h3-4,13-14,16-17,20,22-23,26,31H,5-12H2,1-2H3,(H,32,35)/t20-,22+,23-,26-/m0/s1 AAGFQGZDVAUKDA-VBZBYZBJSA-N 150553 US10238633, Example 227::US8987249, 227::US9713606, 227 Dipeptidyl peptidase 1 1.000 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150553 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150553&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443243 252824804 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732628 COCCN1CCN(CC1)C(=O)c1cc(cs1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C28H34FN5O3S/c1-37-11-10-33-6-8-34(9-7-33)28(36)25-15-21(17-38-25)18-2-3-19(24(29)14-18)12-23(16-30)32-27(35)26-20-4-5-22(13-20)31-26/h2-3,14-15,17,20,22-23,26,31H,4-13H2,1H3,(H,32,35)/t20-,22+,23-,26-/m0/s1 NMBMMMBGRONBTI-VBZBYZBJSA-N 150554 US10238633, Example 228::US8987249, 228::US9713606, 228 Dipeptidyl peptidase 1 1.60 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150554 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150554&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430442 252824805 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732629 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1csc(c1)C(=O)N1CCN(CC1)C1CC1 InChI=1S/C28H32FN5O2S/c29-24-13-17(20-14-25(37-16-20)28(36)34-9-7-33(8-10-34)23-5-6-23)1-2-18(24)11-22(15-30)32-27(35)26-19-3-4-21(12-19)31-26/h1-2,13-14,16,19,21-23,26,31H,3-12H2,(H,32,35)/t19-,21+,22-,26-/m0/s1 AJZSFQXBXRWQNH-IYCJUYGXSA-N 150555 US10238633, Example 229::US8987249, 229::US9713606, 229 Dipeptidyl peptidase 1 1.70 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150555&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443161 252824806 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732630 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1csc(c1)C(=O)N1CCOCC1 InChI=1S/C25H27FN4O3S/c26-21-11-15(18-12-22(34-14-18)25(32)30-5-7-33-8-6-30)1-2-16(21)9-20(13-27)29-24(31)23-17-3-4-19(10-17)28-23/h1-2,11-12,14,17,19-20,23,28H,3-10H2,(H,29,31)/t17-,19+,20-,23-/m0/s1 GNRZSULABSHVGF-USKVXJDGSA-N 150556 US10238633, Example 230::US8987249, 230::US9713606, 230 Dipeptidyl peptidase 1 1.80 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150556 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150556&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430671 252824807 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732631 CC(=O)N1CCN(CC1)C(=O)c1cc(cs1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C27H30FN5O3S/c1-16(34)32-6-8-33(9-7-32)27(36)24-13-20(15-37-24)17-2-3-18(23(28)12-17)10-22(14-29)31-26(35)25-19-4-5-21(11-19)30-25/h2-3,12-13,15,19,21-22,25,30H,4-11H2,1H3,(H,31,35)/t19-,21+,22-,25-/m0/s1 LJOIAAPUDIPGIQ-RBODFLQRSA-N 150557 US10238633, Example 231::US8987249, 231::US9713606, 231 Dipeptidyl peptidase 1 2.20 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150557 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150557&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443159 252824808 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732632 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1csc(c1)C(=O)N1CCN(CC(F)(F)F)CC1 InChI=1S/C27H29F4N5O2S/c28-22-11-16(1-2-17(22)9-21(13-32)34-25(37)24-18-3-4-20(10-18)33-24)19-12-23(39-14-19)26(38)36-7-5-35(6-8-36)15-27(29,30)31/h1-2,11-12,14,18,20-21,24,33H,3-10,15H2,(H,34,37)/t18-,20+,21-,24-/m0/s1 ZKDHZVVYLAZZBU-UQWVPHONSA-N 150558 US10238633, Example 232::US8987249, 232::US9713606, 232 Dipeptidyl peptidase 1 2.20 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150558&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443163 252824809 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732633 CN1CCN(CC1=O)C(=O)c1cc(cs1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C26H28FN5O3S/c1-31-6-7-32(13-23(31)33)26(35)22-11-18(14-36-22)15-2-3-16(21(27)10-15)8-20(12-28)30-25(34)24-17-4-5-19(9-17)29-24/h2-3,10-11,14,17,19-20,24,29H,4-9,13H2,1H3,(H,30,34)/t17-,19+,20-,24-/m0/s1 GZYHERLOGHRBJT-GHCZAOPSSA-N 150559 US10238633, Example 233::US8987249, 233::US9713606, 233 Dipeptidyl peptidase 1 2.20 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150559 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150559&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430672 252824810 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732634 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1csc(c1)C(=O)N1CCN2CCOCC2C1 InChI=1S/C28H32FN5O3S/c29-24-11-17(1-2-18(24)9-22(13-30)32-27(35)26-19-3-4-21(10-19)31-26)20-12-25(38-16-20)28(36)34-6-5-33-7-8-37-15-23(33)14-34/h1-2,11-12,16,19,21-23,26,31H,3-10,14-15H2,(H,32,35)/t19-,21+,22-,23?,26-/m0/s1 LZNDHEGNLIOHKM-RMDYTIRNSA-N 150560 US10238633, Example 234::US8987249, 234::US9713606, 234 Dipeptidyl peptidase 1 3.80 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150560&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443274 252824811 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732635 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1csc(c1)C(=O)NC1CCOCC1 InChI=1S/C26H29FN4O3S/c27-22-11-15(18-12-23(35-14-18)25(32)30-19-5-7-34-8-6-19)1-2-16(22)9-21(13-28)31-26(33)24-17-3-4-20(10-17)29-24/h1-2,11-12,14,17,19-21,24,29H,3-10H2,(H,30,32)(H,31,33)/t17-,20+,21-,24-/m0/s1 UPLHVYVHWWQDBR-QELHCHSZSA-N 150561 US10238633, Example 235::US8987249, 235::US9713606, 235 Dipeptidyl peptidase 1 4.70 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150561 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150561&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430386 252824812 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732636 NC(=O)c1ccc(s1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H21FN4O2S/c22-16-9-12(17-5-6-18(29-17)20(24)27)2-1-11(16)7-15(10-23)26-21(28)19-13-3-4-14(8-13)25-19/h1-2,5-6,9,13-15,19,25H,3-4,7-8H2,(H2,24,27)(H,26,28)/t13-,14+,15-,19-/m0/s1 DNXDSWIEQRGCDX-YGTYGHESSA-N 150562 US10238633, Example 236::US8987249, 236::US9713606, 236 Dipeptidyl peptidase 1 1.60 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150562 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150562&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430394 252824813 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732637 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc(s1)C(=O)N1CCn2nccc2C1 InChI=1S/C27H27FN6O2S/c28-22-13-17(23-5-6-24(37-23)27(36)33-9-10-34-21(15-33)7-8-30-34)2-1-16(22)11-20(14-29)32-26(35)25-18-3-4-19(12-18)31-25/h1-2,5-8,13,18-20,25,31H,3-4,9-12,15H2,(H,32,35)/t18-,19+,20-,25-/m0/s1 DRMBHMUJYOWYMG-ZDQHKECQSA-N 150563 US10238633, Example 237::US8987249, 237::US9713606, 237 Dipeptidyl peptidase 1 4.60 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150563 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150563&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430395 252824814 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732638 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc(o1)C(=O)N1CCN2CCOCC2C1 InChI=1S/C28H32FN5O4/c29-23-13-18(2-1-17(23)11-21(14-30)32-27(35)26-19-3-4-20(12-19)31-26)24-5-6-25(38-24)28(36)34-8-7-33-9-10-37-16-22(33)15-34/h1-2,5-6,13,19-22,26,31H,3-4,7-12,15-16H2,(H,32,35)/t19-,20+,21-,22?,26-/m0/s1 JEOANMFZMPFLAU-QJCBJTJFSA-N 150564 US10238633, Example 238::US8987249, 238::US9713606, 238 Dipeptidyl peptidase 1 14.3 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150564&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443164 252824815 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732639 NC(=O)c1coc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C21H21FN4O3/c22-17-7-12(18-8-14(10-29-18)20(24)27)2-1-11(17)5-16(9-23)26-21(28)19-13-3-4-15(6-13)25-19/h1-2,7-8,10,13,15-16,19,25H,3-6H2,(H2,24,27)(H,26,28)/t13-,15+,16-,19-/m0/s1 AIYPJVNZGWXDOA-YBKUAAOGSA-N 150565 US10238633, Example 239::US8987249, 239::US9713606, 239 Dipeptidyl peptidase 1 3.40 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150565 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150565&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430357 252824816 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732640 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cc(co1)C(=O)N1CCC2N=CC=C2C1 InChI=1S/C28H28FN5O3/c29-23-11-17(25-12-20(15-37-25)28(36)34-8-6-24-19(14-34)5-7-31-24)2-1-16(23)9-22(13-30)33-27(35)26-18-3-4-21(10-18)32-26/h1-2,5,7,11-12,15,18,21-22,24,26,32H,3-4,6,8-10,14H2,(H,33,35)/t18-,21+,22-,24?,26-/m0/s1 IBKXVVFDLAEVPN-SYKNNJIRSA-N 370810 US10238633, Example 240 Dipeptidyl peptidase 1 6.10 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370810 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370810&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 130439801 402357789 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732641 CN1CCN(CC1)C(=O)c1coc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C26H30FN5O3/c1-31-6-8-32(9-7-31)26(34)19-13-23(35-15-19)17-3-2-16(22(27)12-17)10-21(14-28)30-25(33)24-18-4-5-20(11-18)29-24/h2-3,12-13,15,18,20-21,24,29H,4-11H2,1H3,(H,30,33)/t18-,20+,21-,24-/m0/s1 LDLHLKGXKXFHRZ-UQWVPHONSA-N 150567 US10238633, Example 241::US8987249, 241::US9713606, 241 Dipeptidyl peptidase 1 6.80 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150567 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150567&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430227 252824818 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732642 CCNC(=O)c1coc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H25FN4O3/c1-2-26-22(29)16-10-20(31-12-16)14-4-3-13(19(24)9-14)7-18(11-25)28-23(30)21-15-5-6-17(8-15)27-21/h3-4,9-10,12,15,17-18,21,27H,2,5-8H2,1H3,(H,26,29)(H,28,30)/t15-,17+,18-,21-/m0/s1 VMZSCTQFZQDFOI-DKXUYOFUSA-N 150568 US10238633, Example 242::US8987249, 242::US9713606, 242 Dipeptidyl peptidase 1 10.9 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150568&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430247 252824819 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732643 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnn(c1)S(=O)(=O)c1ccccc1 InChI=1S/C25H24FN5O3S/c26-23-12-16(19-14-28-31(15-19)35(33,34)22-4-2-1-3-5-22)6-7-17(23)10-21(13-27)30-25(32)24-18-8-9-20(11-18)29-24/h1-7,12,14-15,18,20-21,24,29H,8-11H2,(H,30,32)/t18-,20+,21-,24-/m0/s1 QABZRGUXQDPQLL-UQWVPHONSA-N 150569 US10238633, Example 243::US8987249, 243::US9713606, 243 Dipeptidyl peptidase 1 4.80 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150569 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150569&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430207 252824820 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732644 NC(=O)c1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H23FN4O2/c24-20-11-14(13-2-1-3-17(8-13)22(26)29)4-5-15(20)9-19(12-25)28-23(30)21-16-6-7-18(10-16)27-21/h1-5,8,11,16,18-19,21,27H,6-7,9-10H2,(H2,26,29)(H,28,30)/t16-,18+,19-,21-/m0/s1 URKPBBPYGGQLCL-KRQVXIAISA-N 150570 US10238633, Example 244::US8987249, 244::US9713606, 244 Dipeptidyl peptidase 1 3.70 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150570 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150570&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430260 252824821 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732645 CN1CCN(CC1)C(=O)c1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C28H32FN5O2/c1-33-9-11-34(12-10-33)28(36)22-4-2-3-18(13-22)19-5-6-20(25(29)16-19)14-24(17-30)32-27(35)26-21-7-8-23(15-21)31-26/h2-6,13,16,21,23-24,26,31H,7-12,14-15H2,1H3,(H,32,35)/t21-,23+,24-,26-/m0/s1 VFHWVMMVSYURFG-YUZJIJRXSA-N 150571 US10238633, Example 245::US8987249, 245::US9713606, 245 Dipeptidyl peptidase 1 5.90 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150571 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150571&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443260 252824822 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732646 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc(cc1)S(=O)(=O)N1CCC(F)(F)CC1 InChI=1S/C27H29F3N4O3S/c28-24-15-18(17-4-7-23(8-5-17)38(36,37)34-11-9-27(29,30)10-12-34)1-2-19(24)13-22(16-31)33-26(35)25-20-3-6-21(14-20)32-25/h1-2,4-5,7-8,15,20-22,25,32H,3,6,9-14H2,(H,33,35)/t20-,21+,22-,25-/m0/s1 DMXKZSZRABVDLH-MTQWNXOMSA-N 150572 BDBM263819::US10238633, Example 246::US8987249, 246 Dipeptidyl peptidase 1 5.90 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150572 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150572&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430686 252824823 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732647 CN1CCCN(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H30FN5O/c1-27-7-2-8-28(10-9-27)19-6-4-15(20(23)13-19)11-18(14-24)26-22(29)21-16-3-5-17(12-16)25-21/h4,6,13,16-18,21,25H,2-3,5,7-12H2,1H3,(H,26,29)/t16-,17+,18-,21-/m0/s1 JUIRQFMPMAKJMC-NYUBLWNDSA-N 150573 US10238633, Example 247::US8987249, 247::US9713606, 247 Dipeptidyl peptidase 1 8.40 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150573 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150573&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430673 252824824 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732648 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCC2C(CCNC2=O)C1 InChI=1S/C24H30FN5O2/c25-21-11-19(30-8-6-20-16(13-30)5-7-27-23(20)31)4-2-14(21)9-18(12-26)29-24(32)22-15-1-3-17(10-15)28-22/h2,4,11,15-18,20,22,28H,1,3,5-10,13H2,(H,27,31)(H,29,32)/t15-,16?,17+,18-,20?,22-/m0/s1 PMZMGDBQXVWCAC-GAGFYFTPSA-N 150574 US10238633, Example 248::US8987249, 248::US9713606, 248 Dipeptidyl peptidase 1 18.0 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150574 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150574&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430639 252824825 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732649 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCN2CCOC[C@@H]2C1 InChI=1S/C23H30FN5O2/c24-21-11-19(29-6-5-28-7-8-31-14-20(28)13-29)4-2-15(21)9-18(12-25)27-23(30)22-16-1-3-17(10-16)26-22/h2,4,11,16-18,20,22,26H,1,3,5-10,13-14H2,(H,27,30)/t16-,17+,18-,20-,22-/m0/s1 SOLOVPGTCODBHF-FFUNNMLOSA-N 150575 US10238633, Example 249::US8987249, 249::US9713606, 249 Dipeptidyl peptidase 1 6.30 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150575&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430827 252824826 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732650 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCN2CCOC[C@H]2C1 InChI=1S/C23H30FN5O2/c24-21-11-19(29-6-5-28-7-8-31-14-20(28)13-29)4-2-15(21)9-18(12-25)27-23(30)22-16-1-3-17(10-16)26-22/h2,4,11,16-18,20,22,26H,1,3,5-10,13-14H2,(H,27,30)/t16-,17+,18-,20+,22-/m0/s1 SOLOVPGTCODBHF-JAZLEBMFSA-N 150576 US10238633, Example 250::US8987249, 250::US9713606, 250 Dipeptidyl peptidase 1 4.20 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150576 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150576&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430699 252824827 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732651 CC(C)c1cc(ccc1S(C)=O)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C26H30FN3O2S/c1-15(2)22-12-16(7-9-24(22)33(3)32)17-4-5-18(23(27)13-17)10-21(14-28)30-26(31)25-19-6-8-20(11-19)29-25/h4-5,7,9,12-13,15,19-21,25,29H,6,8,10-11H2,1-3H3,(H,30,31)/t19-,20+,21-,25-,33?/m0/s1 ZPKAAZKAWPZZBG-QGBJVGRCSA-N 263824 US10238633, Example 251::US9713606, 251 Dipeptidyl peptidase 1 11.5 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263824&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430239 377002726 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732652 CS(=O)(=O)c1ccc(cc1OCC(F)F)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C25H26F3N3O4S/c1-36(33,34)22-7-5-15(11-21(22)35-13-23(27)28)14-2-3-16(20(26)10-14)8-19(12-29)31-25(32)24-17-4-6-18(9-17)30-24/h2-3,5,7,10-11,17-19,23-24,30H,4,6,8-9,13H2,1H3,(H,31,32)/t17-,18+,19-,24-/m0/s1 FJAZHJZGIXPLOY-YDLHNXBPSA-N 150578 US10238633, Example 252::US8987249, 252::US9713606, 252 Dipeptidyl peptidase 1 3.80 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150578&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430228 252824829 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732653 CNc1nc2cc(ccc2n1C)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C25H27FN6O/c1-28-25-31-21-12-15(6-8-22(21)32(25)2)14-3-4-16(20(26)11-14)9-19(13-27)30-24(33)23-17-5-7-18(10-17)29-23/h3-4,6,8,11-12,17-19,23,29H,5,7,9-10H2,1-2H3,(H,28,31)(H,30,33)/t17-,18+,19-,23-/m0/s1 VPLUWXLMJBCMPZ-YWNPBTLJSA-N 150579 US10238633, Example 253::US8987249, 253::US9713606, 253 Dipeptidyl peptidase 1 11.0 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150579&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443262 252824830 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732654 Cn1cc(ccc1=O)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H23FN4O2/c1-27-12-16(5-7-20(27)28)13-2-3-14(19(23)10-13)8-18(11-24)26-22(29)21-15-4-6-17(9-15)25-21/h2-3,5,7,10,12,15,17-18,21,25H,4,6,8-9H2,1H3,(H,26,29)/t15-,17+,18-,21-/m0/s1 DVAYQWABFZKMAR-DKXUYOFUSA-N 150580 US10238633, Example 254::US8987249, 254::US9713606, 254 Dipeptidyl peptidase 1 2.00 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150580 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150580&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430261 252824831 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732655 Cn1ccc(cc1=O)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H23FN4O2/c1-27-7-6-14(11-20(27)28)13-2-3-15(19(23)10-13)8-18(12-24)26-22(29)21-16-4-5-17(9-16)25-21/h2-3,6-7,10-11,16-18,21,25H,4-5,8-9H2,1H3,(H,26,29)/t16-,17+,18-,21-/m0/s1 ACSGJNZSMAZGRN-NYUBLWNDSA-N 150581 US10238633, Example 255::US8987249, 255::US9713606, 255 Dipeptidyl peptidase 1 10.9 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150581 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150581&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430262 252824832 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732656 CN(C)CCn1ccc(cc1=O)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C25H30FN5O2/c1-30(2)9-10-31-8-7-17(14-23(31)32)16-3-4-18(22(26)13-16)11-21(15-27)29-25(33)24-19-5-6-20(12-19)28-24/h3-4,7-8,13-14,19-21,24,28H,5-6,9-12H2,1-2H3,(H,29,33)/t19-,20+,21-,24-/m0/s1 YVLKOTSUWUCUKO-XARGGIHNSA-N 150582 US10238633, Example 256::US8987249, 256::US9713606, 256 Dipeptidyl peptidase 1 26.3 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150582 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150582&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430844 252824833 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732657 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cc[nH]c(=O)c1 150583 US10238633, Example 257::US8987249, 257::US9713606, 257 Dipeptidyl peptidase 1 39.9 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150583 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150583&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937200 252824834 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732658 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc(=O)[nH]c1 150584 US10238633, Example 258::US8987249, 258::US9713606, 258 Dipeptidyl peptidase 1 7.90 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150584 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150584&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 127053696 252824835 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732659 CS(C)(=O)=Nc1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H27FN4O2S/c1-32(2,31)29-20-5-3-4-15(10-20)16-6-7-17(22(25)13-16)11-21(14-26)28-24(30)23-18-8-9-19(12-18)27-23/h3-7,10,13,18-19,21,23,27H,8-9,11-12H2,1-2H3,(H,28,30)/t18-,19+,21-,23-/m0/s1 IUJZTLDIIDKLJO-QRICJDHISA-N 150585 US10238633, Example 259::US8987249, 259::US9713606, 259 Dipeptidyl peptidase 1 6.00 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150585 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150585&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430810 252824836 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732660 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnn(C[C@H]2CCCO2)c1 InChI=1S/C24H28FN5O2/c25-22-10-15(18-12-27-30(13-18)14-21-2-1-7-32-21)3-4-16(22)8-20(11-26)29-24(31)23-17-5-6-19(9-17)28-23/h3-4,10,12-13,17,19-21,23,28H,1-2,5-9,14H2,(H,29,31)/t17-,19+,20-,21+,23-/m0/s1 HMZMPMLDAMDPBI-YMBXHIRXSA-N 150586 US10238633, Example 260::US8987249, 260::US9713606, 260 Dipeptidyl peptidase 1 3.50 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150586 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150586&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430801 252824837 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732661 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnn(C[C@@H]2CCCO2)c1 InChI=1S/C24H28FN5O2/c25-22-10-15(18-12-27-30(13-18)14-21-2-1-7-32-21)3-4-16(22)8-20(11-26)29-24(31)23-17-5-6-19(9-17)28-23/h3-4,10,12-13,17,19-21,23,28H,1-2,5-9,14H2,(H,29,31)/t17-,19+,20-,21-,23-/m0/s1 HMZMPMLDAMDPBI-NROJZILJSA-N 150587 US10238633, Example 261::US8987249, 261::US9713606, 261 Dipeptidyl peptidase 1 4.20 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150587 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150587&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430756 252824838 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732662 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnn(C[C@@H]2CCOC2)c1 InChI=1S/C24H28FN5O2/c25-22-9-16(19-11-27-30(13-19)12-15-5-6-32-14-15)1-2-17(22)7-21(10-26)29-24(31)23-18-3-4-20(8-18)28-23/h1-2,9,11,13,15,18,20-21,23,28H,3-8,12,14H2,(H,29,31)/t15-,18-,20+,21-,23-/m0/s1 CWXBPKJABGXNSH-WNZZMIDNSA-N 150588 US10238633, Example 262::US8987249, 262::US9713606, 262 Dipeptidyl peptidase 1 6.40 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150588 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150588&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430757 252824839 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732663 CS(=O)(=NC#N)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H24FN5O2S/c1-33(32,28-14-27)21-8-5-15(6-9-21)16-2-3-17(22(25)12-16)10-20(13-26)30-24(31)23-18-4-7-19(11-18)29-23/h2-3,5-6,8-9,12,18-20,23,29H,4,7,10-11H2,1H3,(H,30,31)/t18-,19+,20-,23-,33?/m0/s1 JMXAQAKZQYJMRJ-PVEGDPQMSA-N 150589 US10238633, Example 263::US8987249, 263::US9713606, 263 Dipeptidyl peptidase 1 11.8 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150589&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430784 252824840 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732664 CS(=O)(=Nc1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1)C1CCOCC1 InChI=1S/C28H33FN4O3S/c1-37(35,25-9-11-36-12-10-25)33-23-4-2-3-18(13-23)19-5-6-20(26(29)16-19)14-24(17-30)32-28(34)27-21-7-8-22(15-21)31-27/h2-6,13,16,21-22,24-25,27,31H,7-12,14-15H2,1H3,(H,32,34)/t21-,22+,24-,27-,37?/m0/s1 OJKBVCYANOMNAF-JOPHUIKPSA-N 150590 US10238633, Example 264::US8987249, 264::US9713606, 264 Dipeptidyl peptidase 1 17.0 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150590 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150590&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430866 252824841 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732665 CS(=O)c1cc(=O)n(cc1F)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H22F2N4O3S/c1-32(31)19-9-20(29)28(11-18(19)24)16-5-3-12(17(23)8-16)6-15(10-25)27-22(30)21-13-2-4-14(7-13)26-21/h3,5,8-9,11,13-15,21,26H,2,4,6-7H2,1H3,(H,27,30)/t13-,14+,15-,21-,32?/m0/s1 CVPOOVIOJPARFP-LDEKDMLCSA-N 150591 US10238633, Example 265::US8987249, 265::US9713606, 265 Dipeptidyl peptidase 1 62.7 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150591 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150591&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430867 252824842 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732666 CS(=O)(=O)c1ccn(-c2ccc(C[C@H](NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)c(F)c2)c(=O)c1 InChI=1S/C22H23FN4O4S/c1-32(30,31)18-6-7-27(20(28)11-18)17-5-3-13(19(23)10-17)8-16(12-24)26-22(29)21-14-2-4-15(9-14)25-21/h3,5-7,10-11,14-16,21,25H,2,4,8-9H2,1H3,(H,26,29)/t14-,15+,16-,21-/m0/s1 KKPLONFOCYWZDO-YJXLLHPSSA-N 150592 US10238633, Example 266::US8987249, 266::US9713606, 266 Dipeptidyl peptidase 1 43.7 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150592 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150592&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430406 252824843 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732667 CC(C)N1CCCN(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H34FN5O/c1-16(2)29-8-3-9-30(11-10-29)21-7-5-17(22(25)14-21)12-20(15-26)28-24(31)23-18-4-6-19(13-18)27-23/h5,7,14,16,18-20,23,27H,3-4,6,8-13H2,1-2H3,(H,28,31)/t18-,19+,20-,23-/m0/s1 WFHYTCOTCREJLJ-SRYPRDQNSA-N 150593 US10238633, Example 267::US8987249, 267::US9713606, 267 Dipeptidyl peptidase 1 10.5 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150593 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150593&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430443 252824844 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732668 CC(C)(C)N1CCN(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H34FN5O/c1-24(2,3)30-10-8-29(9-11-30)20-7-5-16(21(25)14-20)12-19(15-26)28-23(31)22-17-4-6-18(13-17)27-22/h5,7,14,17-19,22,27H,4,6,8-13H2,1-3H3,(H,28,31)/t17-,18+,19-,22-/m0/s1 GZNWGNOSEGSJHK-WEMPKCCASA-N 150594 US10238633, Example 268::US8987249, 268::US9713606, 268 Dipeptidyl peptidase 1 11.1 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150594 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150594&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430444 252824845 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732669 CO[C@@H]1C[C@@H]2CN(CCN2C1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H32FN5O2/c1-32-21-10-20-13-29(6-7-30(20)14-21)19-5-3-15(22(25)11-19)8-18(12-26)28-24(31)23-16-2-4-17(9-16)27-23/h3,5,11,16-18,20-21,23,27H,2,4,6-10,13-14H2,1H3,(H,28,31)/t16-,17+,18-,20+,21+,23-/m0/s1 VIAZGHFEVYETOO-RWYQBMLRSA-N 150595 US10238633, Example 269::US8987249, 269::US9713606, 269 Dipeptidyl peptidase 1 9.40 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150595 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150595&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430423 252824846 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732670 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCN2CCC[C@H]2C1 InChI=1S/C23H30FN5O/c24-21-12-19(29-9-8-28-7-1-2-20(28)14-29)6-4-15(21)10-18(13-25)27-23(30)22-16-3-5-17(11-16)26-22/h4,6,12,16-18,20,22,26H,1-3,5,7-11,14H2,(H,27,30)/t16-,17+,18-,20-,22-/m0/s1 HLJGWEHAZHBPGN-FFUNNMLOSA-N 150596 US10238633, Example 270::US8987249, 270::US9713606, 270 Dipeptidyl peptidase 1 6.30 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150596 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150596&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430398 252824847 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732671 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCCN2CCCC2C1 InChI=1S/C24H32FN5O/c25-22-13-20(30-10-2-9-29-8-1-3-21(29)15-30)7-5-16(22)11-19(14-26)28-24(31)23-17-4-6-18(12-17)27-23/h5,7,13,17-19,21,23,27H,1-4,6,8-12,15H2,(H,28,31)/t17-,18+,19-,21?,23-/m0/s1 LEQJDFRTVFEHSE-BRJVMOAUSA-N 150597 US10238633, Example 271::US8987249, 271::US9713606, 271 Dipeptidyl peptidase 1 5.90 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150597&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430445 252824848 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732672 CCN1CCN(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H30FN5O/c1-2-27-7-9-28(10-8-27)19-6-4-15(20(23)13-19)11-18(14-24)26-22(29)21-16-3-5-17(12-16)25-21/h4,6,13,16-18,21,25H,2-3,5,7-12H2,1H3,(H,26,29)/t16-,17+,18-,21-/m0/s1 OQJKHSTWNPGKCN-NYUBLWNDSA-N 150598 US10238633, Example 272::US8987249, 272::US9713606, 272 Dipeptidyl peptidase 1 6.80 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150598&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430648 252824849 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732673 CCc1cc(nn1CC(C)C)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C25H32FN5O/c1-4-21-12-23(30-31(21)14-15(2)3)17-6-5-16(22(26)11-17)9-20(13-27)29-25(32)24-18-7-8-19(10-18)28-24/h5-6,11-12,15,18-20,24,28H,4,7-10,14H2,1-3H3,(H,29,32)/t18-,19+,20-,24-/m0/s1 QKCJEPXSJFAOTH-VKDGWMQASA-N 150599 US10238633, Example 273::US8987249, 273::US9713606, 273 Dipeptidyl peptidase 1 28.9 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150599 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150599&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430659 252824850 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732674 CS(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H24FN3O2S/c1-30(29)20-8-5-14(6-9-20)15-2-3-16(21(24)12-15)10-19(13-25)27-23(28)22-17-4-7-18(11-17)26-22/h2-3,5-6,8-9,12,17-19,22,26H,4,7,10-11H2,1H3,(H,27,28)/t17-,18+,19-,22-,30?/m0/s1 SDOAKBZNSFVUJC-NVFJITABSA-N 150600 US10238633, Example 274::US8987249, 274::US9713606, 274 Dipeptidyl peptidase 1 6.50 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150600 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150600&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430661 252824851 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732675 CCOc1cc(cc(c1)S(C)(=O)=O)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C25H28FN3O4S/c1-3-33-21-10-18(11-22(13-21)34(2,31)32)15-4-5-16(23(26)12-15)8-20(14-27)29-25(30)24-17-6-7-19(9-17)28-24/h4-5,10-13,17,19-20,24,28H,3,6-9H2,1-2H3,(H,29,30)/t17-,19+,20-,24-/m0/s1 YXBZSIUIDAWIIE-GHCZAOPSSA-N 150601 US10238633, Example 275::US8987249, 275::US9713606, 275 Dipeptidyl peptidase 1 33.0 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150601 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150601&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430649 252824852 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732676 CS(=O)(=O)c1cc(OCC(F)(F)F)cc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C25H25F4N3O4S/c1-37(34,35)21-9-17(8-20(11-21)36-13-25(27,28)29)14-2-3-15(22(26)10-14)6-19(12-30)32-24(33)23-16-4-5-18(7-16)31-23/h2-3,8-11,16,18-19,23,31H,4-7,13H2,1H3,(H,32,33)/t16-,18+,19-,23-/m0/s1 NOGUIGWOYFVCHA-FAODYONGSA-N 150602 US10238633, Example 276::US8987249, 276::US9713606, 276 Dipeptidyl peptidase 1 14.1 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150602&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430821 252824853 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732677 CN(C)CCCN1C(=O)Cc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C29H34FN5O2/c1-34(2)10-3-11-35-26-15-19(5-7-21(26)16-27(35)36)18-4-6-20(25(30)14-18)12-24(17-31)33-29(37)28-22-8-9-23(13-22)32-28/h4-7,14-15,22-24,28,32H,3,8-13,16H2,1-2H3,(H,33,37)/t22-,23+,24-,28-/m0/s1 XVWGIESADAKPIF-IMBSWCNGSA-N 150603 US10238633, Example 277::US8987249, 277::US9713606, 277 Dipeptidyl peptidase 1 3.00 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150603 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150603&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443263 252824854 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732678 CN(C)CCN1C(=O)Cc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C28H32FN5O2/c1-33(2)9-10-34-25-14-18(4-6-20(25)15-26(34)35)17-3-5-19(24(29)13-17)11-23(16-30)32-28(36)27-21-7-8-22(12-21)31-27/h3-6,13-14,21-23,27,31H,7-12,15H2,1-2H3,(H,32,36)/t21-,22+,23-,27-/m0/s1 AWNMFDZAZNAOSJ-GIRPNKPCSA-N 150604 US10238633, Example 278::US8987249, 278::US9713606, 278 Dipeptidyl peptidase 1 1.000 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150604 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150604&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430474 252824855 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732679 CN(C)CCN1C(=O)Cc2cc(ccc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C28H32FN5O2/c1-33(2)9-10-34-25-8-6-17(11-21(25)15-26(34)35)18-3-4-19(24(29)14-18)12-23(16-30)32-28(36)27-20-5-7-22(13-20)31-27/h3-4,6,8,11,14,20,22-23,27,31H,5,7,9-10,12-13,15H2,1-2H3,(H,32,36)/t20-,22+,23-,27-/m0/s1 NPDKQIXUJNALPW-XUTUTRJZSA-N 150605 US10238633, Example 279::US8987249, 279::US9713606, 279 Dipeptidyl peptidase 1 5.50 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150605 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150605&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430478 252824856 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732680 CC(C)N1CCC(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H33FN4O/c1-15(2)29-9-7-16(8-10-29)17-3-4-18(22(25)13-17)11-21(14-26)28-24(30)23-19-5-6-20(12-19)27-23/h3-4,13,15-16,19-21,23,27H,5-12H2,1-2H3,(H,28,30)/t19-,20+,21-,23-/m0/s1 VJGDLRYVNAZRGF-KGSLCBSSSA-N 150606 US10238633, Example 280::US8987249, 280::US9713606, 280 Dipeptidyl peptidase 1 21.2 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150606 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150606&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430473 252824857 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732681 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)C1=CCN2CCOCC2C1 InChI=1S/C24H29FN4O2/c25-22-12-15(16-5-6-29-7-8-31-14-21(29)11-16)1-2-17(22)9-20(13-26)28-24(30)23-18-3-4-19(10-18)27-23/h1-2,5,12,18-21,23,27H,3-4,6-11,14H2,(H,28,30)/t18-,19+,20-,21?,23-/m0/s1 CMFKDMUAZSMZET-SIKKGAFYSA-N 150607 US10238633, Example 281::US8987249, 281::US9713606, 281 Dipeptidyl peptidase 1 3.30 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150607 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150607&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430479 252824858 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732682 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)C1=CC2COCCN2CC1 InChI=1S/C24H29FN4O2/c25-22-12-15(16-5-6-29-7-8-31-14-21(29)11-16)1-2-17(22)9-20(13-26)28-24(30)23-18-3-4-19(10-18)27-23/h1-2,11-12,18-21,23,27H,3-10,14H2,(H,28,30)/t18-,19+,20-,21?,23-/m0/s1 KYHQETISGYHVCF-SIKKGAFYSA-N 150608 US10238633, Example 282::US8987249, 282::US9713606, 282 Dipeptidyl peptidase 1 3.70 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150608&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430481 252824859 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732683 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)[C@@H]1CCN2CCOC[C@H]2C1 InChI=1S/C24H31FN4O2/c25-22-12-15(16-5-6-29-7-8-31-14-21(29)11-16)1-2-17(22)9-20(13-26)28-24(30)23-18-3-4-19(10-18)27-23/h1-2,12,16,18-21,23,27H,3-11,14H2,(H,28,30)/t16-,18+,19-,20+,21-,23+/m1/s1 UVMGBTLVJPDNFH-IXRJDROYSA-N 150609 US10238633, Example 283::US8987249, 283::US9713606, 283 Dipeptidyl peptidase 1 9.70 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150609 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150609&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430740 252824860 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732684 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)[C@H]1CCN2CCOC[C@H]2C1 InChI=1S/C24H31FN4O2/c25-22-12-15(16-5-6-29-7-8-31-14-21(29)11-16)1-2-17(22)9-20(13-26)28-24(30)23-18-3-4-19(10-18)27-23/h1-2,12,16,18-21,23,27H,3-11,14H2,(H,28,30)/t16-,18-,19+,20-,21+,23-/m0/s1 UVMGBTLVJPDNFH-LYAMXQPKSA-N 150610 US10238633, Example 284::US8987249, 284::US9713606, 284 Dipeptidyl peptidase 1 13.8 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150610 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150610&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430753 252824861 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732685 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-n1cc(cn1)C(F)(F)F InChI=1S/C20H19F4N5O/c21-17-7-16(29-10-13(9-26-29)20(22,23)24)4-2-11(17)5-15(8-25)28-19(30)18-12-1-3-14(6-12)27-18/h2,4,7,9-10,12,14-15,18,27H,1,3,5-6H2,(H,28,30)/t12-,14+,15-,18-/m0/s1 KLUIZDATHDMRJM-OGIUKLMXSA-N 150611 US10238633, Example 285::US8987249, 285::US9713606, 285 Dipeptidyl peptidase 1 9.30 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150611 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150611&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430861 252824862 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732686 CN(C)C(=O)c1cnn(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H25FN6O2/c1-28(2)22(31)15-11-25-29(12-15)18-6-4-13(19(23)9-18)7-17(10-24)27-21(30)20-14-3-5-16(8-14)26-20/h4,6,9,11-12,14,16-17,20,26H,3,5,7-8H2,1-2H3,(H,27,30)/t14-,16+,17-,20-/m0/s1 ADLODPBTXCWQIJ-FORWCCJISA-N 150612 US10238633, Example 286::US8987249, 286::US9713606, 286 Dipeptidyl peptidase 1 38.9 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150612 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150612&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430862 252824863 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732687 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-n1cc(cn1)C(=O)N1CCOCC1 InChI=1S/C24H27FN6O3/c25-21-11-20(31-14-17(13-27-31)24(33)30-5-7-34-8-6-30)4-2-15(21)9-19(12-26)29-23(32)22-16-1-3-18(10-16)28-22/h2,4,11,13-14,16,18-19,22,28H,1,3,5-10H2,(H,29,32)/t16-,18+,19-,22-/m0/s1 PUDLCFJOVIUEHT-ZBPHCFQXSA-N 150613 US10238633, Example 287::US8987249, 287::US9713606, 287 Dipeptidyl peptidase 1 39.7 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150613 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150613&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430863 252824864 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732688 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc(o1)C(=O)N1CCOCC1 InChI=1S/C25H27FN4O4/c26-20-13-16(21-5-6-22(34-21)25(32)30-7-9-33-10-8-30)2-1-15(20)11-19(14-27)29-24(31)23-17-3-4-18(12-17)28-23/h1-2,5-6,13,17-19,23,28H,3-4,7-12H2,(H,29,31)/t17-,18+,19-,23-/m0/s1 QLIQIELZFMSNMZ-YWNPBTLJSA-N 150614 US10238633, Example 288::US8987249, 288::US9713606, 288 Dipeptidyl peptidase 1 2.30 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150614 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150614&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430829 252824865 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732689 CN1CCN(CC1)C(=O)c1ccc(o1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C26H30FN5O3/c1-31-8-10-32(11-9-31)26(34)23-7-6-22(35-23)17-3-2-16(21(27)14-17)12-20(15-28)30-25(33)24-18-4-5-19(13-18)29-24/h2-3,6-7,14,18-20,24,29H,4-5,8-13H2,1H3,(H,30,33)/t18-,19+,20-,24-/m0/s1 WONAWGLRVBZQLT-VKDGWMQASA-N 150615 US10238633, Example 289::US8987249, 289::US9713606, 289 Dipeptidyl peptidase 1 2.50 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150615 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150615&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90443284 252824866 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732690 Fc1cc(OCc2ccccc2)ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N InChI=1S/C23H24FN3O2/c24-21-12-20(29-14-15-4-2-1-3-5-15)9-7-16(21)10-19(13-25)27-23(28)22-17-6-8-18(11-17)26-22/h1-5,7,9,12,17-19,22,26H,6,8,10-11,14H2,(H,27,28)/t17-,18+,19-,22-/m0/s1 ODYJNVQNAFLEJI-WEMPKCCASA-N 150616 US10238633, Example 290::US8987249, 290::US9713606, 290 Dipeptidyl peptidase 1 20.6 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150616 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150616&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430850 252824867 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732691 NC(=O)c1cc(F)c2[nH]c(=O)c3cc(CC(NC(=O)[C@H]4N[C@@H]5CC[C@H]4C5)C#N)ccc3c2c1 150617 US10238633, Example 291::US8987249, 291::US9713606, 291 Dipeptidyl peptidase 1 5.90 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150617&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937201 252824868 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732692 Fc1cc2c3ccc(cc3[nH]c(=O)c2cc1CC(NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)C#N 150618 US10238633, Example 292::US8987249, 292::US9713606, 292 Dipeptidyl peptidase 1 0.900 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150618 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150618&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937202 252824869 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732693 Fc1ccc2c(c1)[nH]c(=O)c1cc(CC(NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)c(F)cc21 150619 US10238633, Example 293::US8987249, 293::US9713606, 293 Dipeptidyl peptidase 1 1.30 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150619 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150619&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937203 252824870 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732694 Fc1cc2c3ccccc3[nH]c(=O)c2cc1CC(NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N 150620 US10238633, Example 294::US8987249, 294::US9713606, 294 Dipeptidyl peptidase 1 1.60 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150620&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937204 252824871 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732695 Fc1ccc2[nH]c(=O)c3cc(CC(NC(=O)[C@H]4N[C@@H]5CC[C@H]4C5)C#N)c(F)cc3c2c1 150621 US10238633, Example 295::US8987249, 295::US9713606, 295 Dipeptidyl peptidase 1 2.10 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150621&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937205 252824872 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732696 Fc1cc2c3ccc(CC(NC(=O)[C@H]4N[C@@H]5CC[C@H]4C5)C#N)cc3c(=O)[nH]c2c(F)c1F 150622 US10238633, Example 296::US8987249, 296::US9713606, 296 Dipeptidyl peptidase 1 2.90 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150622&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937206 252824873 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732697 Clc1ccc2c(c1)[nH]c(=O)c1cc(CC(NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)ccc21 150623 US10238633, Example 297::US8987249, 297::US9713606, 297 Dipeptidyl peptidase 1 3.20 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150623&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937207 252824874 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732698 O=C(NC(Cc1ccc2c3cc(ccc3[nH]c(=O)c2c1)C#N)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 150624 US10238633, Example 298::US8987249, 298::US9713606, 298 Dipeptidyl peptidase 1 3.20 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150624 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150624&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937208 252824875 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732699 COC(=O)c1ccc2[nH]c(=O)c3cc(CC(NC(=O)[C@H]4N[C@@H]5CC[C@H]4C5)C#N)ccc3c2c1 150625 US10238633, Example 299::US8987249, 299::US9713606, 299 Dipeptidyl peptidase 1 3.20 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150625&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937209 252824876 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732700 Fc1ccc2c3ccc(CC(NC(=O)[C@H]4N[C@@H]5CC[C@H]4C5)C#N)cc3c(=O)[nH]c2c1F 150626 US10238633, Example 300::US8987249, 300::US9713606, 300 Dipeptidyl peptidase 1 3.80 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150626&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937210 252824877 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732701 FC(F)(F)c1ccc2c(c1)[nH]c(=O)c1cc(C[C@H](NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)ccc21 150627 US10238633, Example 301::US8987249, 301::US9713606, 301 Dipeptidyl peptidase 1 4.50 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150627 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150627&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937211 252824878 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732702 FC(F)(F)c1cc2[nH]c(=O)c3cc(CC(NC(=O)[C@H]4N[C@@H]5CC[C@H]4C5)C#N)ccc3c2cc1C#N 150628 US10238633, Example 302::US8987249, 302::US9713606, 302 Dipeptidyl peptidase 1 4.70 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150628 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150628&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937212 252824879 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732703 Cn1c2cc(ccc2c2ccc(CC(NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)cc2c1=O)C#N InChI=1S/C25H23N5O2/c1-30-22-10-15(12-26)3-7-20(22)19-6-2-14(9-21(19)25(30)32)8-18(13-27)29-24(31)23-16-4-5-17(11-16)28-23/h2-3,6-7,9-10,16-18,23,28H,4-5,8,11H2,1H3,(H,29,31)/t16-,17+,18?,23-/m0/s1 JRJZXYNCCWJCKO-XDGMMDTHSA-N 150629 US10238633, Example 303::US8987249, 303::US9713606, 303 Dipeptidyl peptidase 1 5.00 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150629 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150629&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430280 252824880 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732704 Clc1ccc2[nH]c(=O)c3cc(CC(NC(=O)[C@H]4N[C@@H]5CC[C@H]4C5)C#N)ccc3c2c1 150630 US10238633, Example 304::US8987249, 304::US9713606, 304 Dipeptidyl peptidase 1 6.00 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150630 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150630&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937213 252824881 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732705 Cn1c2cc(Cl)ccc2c2ccc(CC(NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)cc2c1=O InChI=1S/C24H23ClN4O2/c1-29-21-11-15(25)4-7-19(21)18-6-2-13(9-20(18)24(29)31)8-17(12-26)28-23(30)22-14-3-5-16(10-14)27-22/h2,4,6-7,9,11,14,16-17,22,27H,3,5,8,10H2,1H3,(H,28,30)/t14-,16+,17?,22-/m0/s1 SVARUVQPDCVUTH-UHDBIXDDSA-N 150631 US10238633, Example 305::US8987249, 305::US9713606, 305 Dipeptidyl peptidase 1 6.90 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150631 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150631&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90415298 252824882 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732706 CNC(=O)Cc1ccc2[nH]c(=O)c3cc(CC(NC(=O)[C@H]4N[C@@H]5CC[C@H]4C5)C#N)ccc3c2c1 150632 US10238633, Example 306::US8987249, 306::US9713606, 306 Dipeptidyl peptidase 1 7.00 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150632 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150632&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937214 252824883 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732707 Fc1cc(cc2c3ccc(CC(NC(=O)[C@H]4N[C@@H]5CC[C@H]4C5)C#N)cc3c(=O)[nH]c12)C#N 150633 US10238633, Example 307::US8987249, 307::US9713606, 307 Dipeptidyl peptidase 1 7.20 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150633 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150633&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937215 252824884 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732708 Fc1cccc2c3ccc(CC(NC(=O)[C@H]4N[C@@H]5CC[C@H]4C5)C#N)cc3c(=O)[nH]c12 150634 US10238633, Example 308::US8987249, 308::US9713606, 308 Dipeptidyl peptidase 1 8.30 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150634 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150634&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937216 252824885 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732709 O=C(NC(Cc1ccc2c3ccc(cc3[nH]c(=O)c2c1)C#N)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 150635 US10238633, Example 309::US8987249, 309::US9713606, 309 Dipeptidyl peptidase 1 9.10 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150635 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150635&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937217 252824886 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732710 Fc1cc(F)c2[nH]c(=O)c3cc(CC(NC(=O)[C@H]4N[C@@H]5CC[C@H]4C5)C#N)ccc3c2c1 150636 US10238633, Example 310::US8987249, 310::US9713606, 310 Dipeptidyl peptidase 1 9.40 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150636 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150636&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937218 252824887 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732711 COC(=O)c1cccc2c1[nH]c(=O)c1cc(CC(NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)ccc21 150637 US10238633, Example 311::US8987249, 311::US9713606, 311 Dipeptidyl peptidase 1 9.90 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150637 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150637&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937219 252824888 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732712 COc1ccc2[nH]c(=O)c3cc(CC(NC(=O)[C@H]4N[C@@H]5CC[C@H]4C5)C#N)ccc3c2c1 150638 US10238633, Example 312::US8987249, 312::US9713606, 312 Dipeptidyl peptidase 1 11.0 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150638 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150638&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937220 252824889 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732713 CS(=O)(=O)c1ccc2[nH]c(=O)c3cc(CC(NC(=O)[C@H]4N[C@@H]5CC[C@H]4C5)C#N)ccc3c2c1 150639 US10238633, Example 313::US8987249, 313::US9713606, 313 Dipeptidyl peptidase 1 13.6 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150639 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150639&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937221 252824890 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732714 Nc1ccc2[nH]c(=O)c3cc(CC(NC(=O)[C@H]4N[C@@H]5CC[C@H]4C5)C#N)ccc3c2c1 150640 US10238633, Example 314::US8987249, 314::US9713606, 314 Dipeptidyl peptidase 1 14.0 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150640 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150640&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937222 252824891 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732715 Fc1ccc2c(c1)ncc1cc(CC(NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)ccc21 InChI=1S/C23H21FN4O/c24-16-3-6-20-19-5-1-13(7-15(19)12-26-21(20)10-16)8-18(11-25)28-23(29)22-14-2-4-17(9-14)27-22/h1,3,5-7,10,12,14,17-18,22,27H,2,4,8-9H2,(H,28,29)/t14-,17+,18?,22-/m0/s1 QJNLKABXJHEPTA-IHQHAJGLSA-N 150641 US10238633, Example 315::US8987249, 315::US9713606, 315 Dipeptidyl peptidase 1 13.5 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150641 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150641&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90414194 252824892 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732716 O=C(NC(Cc1ccc2c(cnc3ccccc23)c1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 InChI=1S/C23H22N4O/c24-12-18(27-23(28)22-15-6-7-17(11-15)26-22)10-14-5-8-19-16(9-14)13-25-21-4-2-1-3-20(19)21/h1-5,8-9,13,15,17-18,22,26H,6-7,10-11H2,(H,27,28)/t15-,17+,18?,22-/m0/s1 PKYHSYLOBVYURX-JJOTWVSXSA-N 150642 US10238633, Example 316::US8987249, 316::US9713606, 316 Dipeptidyl peptidase 1 42.4 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150642 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150642&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430270 252824893 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732717 Oc1cccc(n1)-c1ccc(F)c(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c1 InChI=1S/C21H21FN4O2/c22-17-7-5-12(18-2-1-3-19(27)26-18)8-14(17)10-16(11-23)25-21(28)20-13-4-6-15(9-13)24-20/h1-3,5,7-8,13,15-16,20,24H,4,6,9-10H2,(H,25,28)(H,26,27)/t13-,15+,16?,20-/m0/s1 IDXWFRRWRADIAT-UMUSXLSISA-N 370887 US10238633, Example 317 Dipeptidyl peptidase 1 52.0 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370887&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 130439748 402357866 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732718 CN1CCN(CC1)c1ccc(F)c(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c1 InChI=1S/C21H28FN5O/c1-26-6-8-27(9-7-26)18-4-5-19(22)15(12-18)11-17(13-23)25-21(28)20-14-2-3-16(10-14)24-20/h4-5,12,14,16-17,20,24H,2-3,6-11H2,1H3,(H,25,28)/t14-,16+,17-,20-/m0/s1 YHGGOZOSHZJPNN-FORWCCJISA-N 150644 US10238633, Example 318::US8987249, 318::US9713606, 318 Dipeptidyl peptidase 1 212 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150644 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150644&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430269 252824895 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732719 CN1CCC(CC1)Oc1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H29FN4O2/c1-27-8-6-18(7-9-27)29-19-5-3-14(20(23)12-19)10-17(13-24)26-22(28)21-15-2-4-16(11-15)25-21/h3,5,12,15-18,21,25H,2,4,6-11H2,1H3,(H,26,28)/t15-,16+,17-,21-/m0/s1 HYUGWMVHDPXQBJ-DLRJPAPCSA-N 150645 US10238633, Example 319::US8987249, 319::US9713606, 319 Dipeptidyl peptidase 1 17.5 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150645 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150645&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90413630 252824896 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732720 CCN1CCC(=CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H29FN4O/c1-2-28-9-7-15(8-10-28)16-3-4-17(21(24)13-16)11-20(14-25)27-23(29)22-18-5-6-19(12-18)26-22/h3-4,7,13,18-20,22,26H,2,5-6,8-12H2,1H3,(H,27,29)/t18-,19+,20-,22-/m0/s1 OZZNAKFBQUXBQF-IIZPIQPGSA-N 150646 US10238633, Example 320::US8987249, 320::US9713606, 320 Dipeptidyl peptidase 1 9.60 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150646 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150646&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430274 252824897 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732721 CN1CCC(C)(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H31FN4O/c1-23(7-9-28(2)10-8-23)17-5-3-15(20(24)13-17)11-19(14-25)27-22(29)21-16-4-6-18(12-16)26-21/h3,5,13,16,18-19,21,26H,4,6-12H2,1-2H3,(H,27,29)/t16-,18+,19-,21-/m0/s1 WMXMRYCYIHGDFQ-KRQVXIAISA-N 150647 US10238633, Example 321::US8987249, 321::US9713606, 321 Dipeptidyl peptidase 1 56.8 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150647 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150647&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430259 252824898 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732722 Fc1cc2c3ccccc3[nH]c(=O)c2cc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N 150648 US10238633, Example 322::US8987249, 322::US9713606, 322 Dipeptidyl peptidase 1 0.800 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150648 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150648&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937223 252824899 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732723 Fc1ccc2c(c1)[nH]c(=O)c1cc(C[C@H](NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)c(F)cc21 150649 US10238633, Example 323::US8987249, 323::US9713606, 323 Dipeptidyl peptidase 1 0.800 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150649 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150649&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937224 252824900 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732724 Fc1ccc2c3cc(F)c(C[C@H](NC(=O)[C@H]4N[C@@H]5CC[C@H]4C5)C#N)cc3c(=O)[nH]c2c1F 150650 US10238633, Example 324::US8987249, 324::US9713606, 324 Dipeptidyl peptidase 1 1.000 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150650 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150650&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937225 252824901 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732725 Fc1cc2c3cc(cc(F)c3[nH]c(=O)c2cc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)C#N 150651 US10238633, Example 325::US8987249, 325::US9713606, 325 Dipeptidyl peptidase 1 1.30 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150651 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150651&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937226 252824902 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732726 Cn1c2ccccc2c2cc(F)c(C[C@H](NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)cc2c1=O InChI=1S/C24H23FN4O2/c1-29-21-5-3-2-4-17(21)18-11-20(25)14(10-19(18)24(29)31)9-16(12-26)28-23(30)22-13-6-7-15(8-13)27-22/h2-5,10-11,13,15-16,22,27H,6-9H2,1H3,(H,28,30)/t13-,15+,16-,22-/m0/s1 WKTMNQATQFDGDF-IZGSKCEXSA-N 150652 US10238633, Example 326::US8987249, 326::US9713606, 326 Dipeptidyl peptidase 1 1.90 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150652 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150652&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430268 252824903 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732727 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CC2(CNC2)C1 InChI=1S/C21H26FN5O/c22-18-7-17(27-11-21(12-27)9-24-10-21)4-2-13(18)5-16(8-23)26-20(28)19-14-1-3-15(6-14)25-19/h2,4,7,14-16,19,24-25H,1,3,5-6,9-12H2,(H,26,28)/t14-,15+,16-,19-/m0/s1 YUZUVEKDYNDTLN-RCJHGTSTSA-N 150653 US10238633, Example 327::US8987249, 327::US9713606, 327 Dipeptidyl peptidase 1 3.40 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150653 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150653&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430656 252824904 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732728 CN1CC2CCC(C1)N2c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H30FN5O/c1-28-12-19-6-7-20(13-28)29(19)18-5-3-14(21(24)10-18)8-17(11-25)27-23(30)22-15-2-4-16(9-15)26-22/h3,5,10,15-17,19-20,22,26H,2,4,6-9,12-13H2,1H3,(H,27,30)/t15-,16+,17-,19?,20?,22-/m0/s1 HTGIRCXAILFFBK-DVFPXELVSA-N 150654 US10238633, Example 328::US8987249, 328::US9713606, 328 Dipeptidyl peptidase 1 4.20 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150654&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430746 252824905 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732729 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1C2CCC1CN(C2)C1CCOC1 InChI=1S/C26H34FN5O2/c27-24-11-20(32-21-5-6-22(32)14-31(13-21)23-7-8-34-15-23)4-2-16(24)9-19(12-28)30-26(33)25-17-1-3-18(10-17)29-25/h2,4,11,17-19,21-23,25,29H,1,3,5-10,13-15H2,(H,30,33)/t17-,18+,19-,21?,22?,23?,25-/m0/s1 CFVCLDGBQIROEH-FHVJXWHLSA-N 150655 US10238633, Example 329::US8987249, 329::US9713606, 329 Dipeptidyl peptidase 1 7.00 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150655&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430697 252824906 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732730 CN1CC2(C1)CN(C2)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C22H28FN5O/c1-27-10-22(11-27)12-28(13-22)18-5-3-14(19(23)8-18)6-17(9-24)26-21(29)20-15-2-4-16(7-15)25-20/h3,5,8,15-17,20,25H,2,4,6-7,10-13H2,1H3,(H,26,29)/t15-,16+,17-,20-/m0/s1 GZROAMVDJTZDHV-CLWJZODNSA-N 150656 US10238633, Example 330::US8987249, 330::US9713606, 330 Dipeptidyl peptidase 1 7.80 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150656 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150656&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430645 252824907 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732731 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCN(CC1)C1CCOC1 InChI=1S/C24H32FN5O2/c25-22-13-20(29-6-8-30(9-7-29)21-5-10-32-15-21)4-2-16(22)11-19(14-26)28-24(31)23-17-1-3-18(12-17)27-23/h2,4,13,17-19,21,23,27H,1,3,5-12,15H2,(H,28,31)/t17-,18+,19-,21?,23-/m0/s1 HQPKYHAECKWQKT-BRJVMOAUSA-N 150657 US10238633, Example 331::US8987249, 331::US9713606, 331 Dipeptidyl peptidase 1 9.30 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150657 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150657&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430646 252824908 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732732 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)C1=CCN(CC1)C1CCOC1 InChI=1S/C25H31FN4O2/c26-23-13-17(16-5-8-30(9-6-16)22-7-10-32-15-22)1-2-18(23)11-21(14-27)29-25(31)24-19-3-4-20(12-19)28-24/h1-2,5,13,19-22,24,28H,3-4,6-12,15H2,(H,29,31)/t19-,20+,21-,22?,24-/m0/s1 HPIWKFZLWFOWST-NMZQLUBISA-N 150658 US10238633, Example 332::US8987249, 332::US9713606, 332 Dipeptidyl peptidase 1 12.9 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150658 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150658&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430834 252824909 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732733 CN1C2CCC1CN(C2)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H30FN5O/c1-28-19-6-7-20(28)13-29(12-19)18-5-3-14(21(24)10-18)8-17(11-25)27-23(30)22-15-2-4-16(9-15)26-22/h3,5,10,15-17,19-20,22,26H,2,4,6-9,12-13H2,1H3,(H,27,30)/t15-,16+,17-,19?,20?,22-/m0/s1 AFPYZOMVCKOSFX-DVFPXELVSA-N 150659 US10238633, Example 333::US8987249, 333::US9713606, 333 Dipeptidyl peptidase 1 15.3 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150659 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150659&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430881 252824910 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732734 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2N(C3CCNCC3)C(=O)Cc2c1 InChI=1S/C29H32FN5O2/c30-25-14-18(17-4-6-26-21(11-17)15-27(36)35(26)24-7-9-32-10-8-24)1-2-19(25)12-23(16-31)34-29(37)28-20-3-5-22(13-20)33-28/h1-2,4,6,11,14,20,22-24,28,32-33H,3,5,7-10,12-13,15H2,(H,34,37)/t20-,22+,23-,28-/m0/s1 DXRXGECGVNYTMC-HQGMYGGFSA-N 150660 US10238633, Example 334::US8987249, 334::US9713606, 334 Dipeptidyl peptidase 1 22.0 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150660 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150660&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430819 252824911 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732735 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCNCC1 InChI=1S/C20H26FN5O/c21-18-11-17(26-7-5-23-6-8-26)4-2-13(18)9-16(12-22)25-20(27)19-14-1-3-15(10-14)24-19/h2,4,11,14-16,19,23-24H,1,3,5-10H2,(H,25,27)/t14-,15+,16-,19-/m0/s1 IMHSIFFWUGPDKM-RCJHGTSTSA-N 150530 BDBM150661::US10238633, Example 335::US8987249, 204::US9713606, 335 Dipeptidyl peptidase 1 24.5 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150530&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430619 252824781 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732736 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCN(CC1)C1CCOCC1 InChI=1S/C25H34FN5O2/c26-23-15-22(31-9-7-30(8-10-31)21-5-11-33-12-6-21)4-2-17(23)13-20(16-27)29-25(32)24-18-1-3-19(14-18)28-24/h2,4,15,18-21,24,28H,1,3,5-14H2,(H,29,32)/t18-,19+,20-,24-/m0/s1 PVGDBPFKTDEZEI-VKDGWMQASA-N 150662 US10238633, Example 336::US8987249, 336::US9713606, 336 Dipeptidyl peptidase 1 24.5 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150662 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150662&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430857 252824913 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732737 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)C1CCN(CC1)C1CCOC1 InChI=1S/C25H33FN4O2/c26-23-13-17(16-5-8-30(9-6-16)22-7-10-32-15-22)1-2-18(23)11-21(14-27)29-25(31)24-19-3-4-20(12-19)28-24/h1-2,13,16,19-22,24,28H,3-12,15H2,(H,29,31)/t19-,20+,21-,22?,24-/m0/s1 WHIXYJGAWIPTFA-NMZQLUBISA-N 150663 US10238633, Example 337::US8987249, 337::US9713606, 337 Dipeptidyl peptidase 1 28.2 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150663 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150663&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430651 252824914 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732738 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)C1CCCN(C1)C1CCOC1 InChI=1S/C25H33FN4O2/c26-23-12-16(19-2-1-8-30(14-19)22-7-9-32-15-22)3-4-17(23)10-21(13-27)29-25(31)24-18-5-6-20(11-18)28-24/h3-4,12,18-22,24,28H,1-2,5-11,14-15H2,(H,29,31)/t18-,19?,20+,21-,22?,24-/m0/s1 PLDLYKGVWLEKJA-DQRHXDIBSA-N 150664 US10238633, Example 338::US8987249, 338::US9713606, 338 Dipeptidyl peptidase 1 44.3 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150664 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150664&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430828 252824915 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732739 CN1CCN(CC1)S(=O)(=O)c1cc(ccc1F)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C27H31F2N5O3S/c1-33-8-10-34(11-9-33)38(36,37)25-15-18(5-7-23(25)28)17-2-3-19(24(29)14-17)12-22(16-30)32-27(35)26-20-4-6-21(13-20)31-26/h2-3,5,7,14-15,20-22,26,31H,4,6,8-13H2,1H3,(H,32,35)/t20-,21+,22-,26-/m0/s1 TYOXDYZNTFEUBD-MSZDEVHKSA-N 150665 US10238633, Example 339::US8987249, 339::US9713606, 339 Dipeptidyl peptidase 1 1.30 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150665&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430640 252824916 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732740 CN1CCCN(CC1)S(=O)(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C28H34FN5O3S/c1-33-11-2-12-34(14-13-33)38(36,37)25-9-6-19(7-10-25)20-3-4-21(26(29)17-20)15-24(18-30)32-28(35)27-22-5-8-23(16-22)31-27/h3-4,6-7,9-10,17,22-24,27,31H,2,5,8,11-16H2,1H3,(H,32,35)/t22-,23+,24-,27-/m0/s1 LFMQCYRRSBXTCL-LAOBSVPGSA-N 150666 US10238633, Example 340::US8987249, 340 Dipeptidyl peptidase 1 1.80 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150666 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150666&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430700 252824917 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732741 O=C(NC(Cc1ccc2c3cccc(C(=O)NC4CC4)c3[nH]c(=O)c2c1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2 150667 US10238633, Example 341::US8987249, 341::US9713606, 341 Dipeptidyl peptidase 1 7.60 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150667 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150667&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91937227 252824918 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732742 CN(C)CCn1cc(ccc1=O)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C25H30FN5O2/c1-30(2)9-10-31-15-19(6-8-23(31)32)16-3-4-17(22(26)13-16)11-21(14-27)29-25(33)24-18-5-7-20(12-18)28-24/h3-4,6,8,13,15,18,20-21,24,28H,5,7,9-12H2,1-2H3,(H,29,33)/t18-,20+,21-,24-/m0/s1 JCPYMYYDSFBUAQ-UQWVPHONSA-N 150668 US10238633, Example 342::US8987249, 342::US9713606, 342 Dipeptidyl peptidase 1 1.30 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150668 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150668&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430321 252824919 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732743 FC(F)Cn1cc(ccc1=O)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H23F3N4O2/c24-19-9-13(16-4-6-21(31)30(11-16)12-20(25)26)1-2-14(19)7-18(10-27)29-23(32)22-15-3-5-17(8-15)28-22/h1-2,4,6,9,11,15,17-18,20,22,28H,3,5,7-8,12H2,(H,29,32)/t15-,17+,18-,22-/m0/s1 XLDYHFLLFRGMMH-PBWVOLNLSA-N 150669 US10238633, Example 343::US8987249, 343::US9713606, 343 Dipeptidyl peptidase 1 4.50 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150669 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150669&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430361 252824920 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732744 CN(C)C1CCCN(C1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H32FN5O/c1-28(2)20-4-3-9-29(14-20)19-8-6-15(21(24)12-19)10-18(13-25)27-23(30)22-16-5-7-17(11-16)26-22/h6,8,12,16-18,20,22,26H,3-5,7,9-11,14H2,1-2H3,(H,27,30)/t16-,17+,18-,20?,22-/m0/s1 GDNGGGSHVJGZPQ-AEJWZEPGSA-N 150670 US10238633, Example 344::US8987249, 344::US9713606, 344 Dipeptidyl peptidase 1 10.00 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150670 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150670&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90413980 252824921 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732745 CN(C)CC1CCCN(C1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H34FN5O/c1-29(2)14-16-4-3-9-30(15-16)21-8-6-17(22(25)12-21)10-20(13-26)28-24(31)23-18-5-7-19(11-18)27-23/h6,8,12,16,18-20,23,27H,3-5,7,9-11,14-15H2,1-2H3,(H,28,31)/t16?,18-,19+,20-,23-/m0/s1 HSYBJTSDYKJCLC-XPNKYNLISA-N 150671 US10238633, Example 345::US8987249, 345::US9713606, 345 Dipeptidyl peptidase 1 18.4 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150671&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430377 252824922 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732746 CN1CCC(CC1)N1C(=O)Cc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C30H34FN5O2/c1-35-10-8-25(9-11-35)36-27-15-19(3-5-21(27)16-28(36)37)18-2-4-20(26(31)14-18)12-24(17-32)34-30(38)29-22-6-7-23(13-22)33-29/h2-5,14-15,22-25,29,33H,6-13,16H2,1H3,(H,34,38)/t22-,23+,24-,29-/m0/s1 NQWFIIUUUKGYJY-MVPDCNEZSA-N 150672 US10238633, Example 346::US8987249, 346::US9713606, 346 Dipeptidyl peptidase 1 1.000 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150672&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430825 252824923 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732747 CNc1nc2cc(ccc2[nH]1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 150673 US10238633, Example 347::US8987249, 347::US9713606, 347 Dipeptidyl peptidase 1 8.50 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150673&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430669 252824924 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732748 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CC2CCN(C3CCOC3)C2C1 InChI=1S/C26H34FN5O2/c27-23-11-21(31-13-18-5-7-32(24(18)14-31)22-6-8-34-15-22)4-2-16(23)9-20(12-28)30-26(33)25-17-1-3-19(10-17)29-25/h2,4,11,17-20,22,24-25,29H,1,3,5-10,13-15H2,(H,30,33)/t17-,18?,19+,20-,22?,24?,25-/m0/s1 HNERTVWQTUOXEG-QOCJVYAVSA-N 150674 US10238633, Example 348::US8987249, 348::US9713606, 348 Dipeptidyl peptidase 1 17.6 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150674 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150674&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430684 252824925 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732749 CN1CCC2CN(CC12)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H30FN5O/c1-28-7-6-16-12-29(13-21(16)28)19-5-3-14(20(24)10-19)8-18(11-25)27-23(30)22-15-2-4-17(9-15)26-22/h3,5,10,15-18,21-22,26H,2,4,6-9,12-13H2,1H3,(H,27,30)/t15-,16?,17+,18-,21?,22-/m0/s1 IJCSTYFRTDTKAN-CHXWQNPLSA-N 150675 US10238633, Example 349::US8987249, 349::US9713606, 349 Dipeptidyl peptidase 1 20.6 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150675&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430670 252824926 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732750 COCCN1CCC(C1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H31FN4O2/c1-30-9-8-28-7-6-18(14-28)15-2-3-16(21(24)12-15)10-20(13-25)27-23(29)22-17-4-5-19(11-17)26-22/h2-3,12,17-20,22,26H,4-11,14H2,1H3,(H,27,29)/t17-,18?,19+,20-,22-/m0/s1 IQICHZGNSROSIQ-FPTDZDEXSA-N 150676 US10238633, Example 350::US8987249, 350::US9713606, 350 Dipeptidyl peptidase 1 38.6 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150676&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430831 252824927 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732751 Fc1c(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)ccc2CC(CCc12)N1CCOCC1 InChI=1S/C24H31FN4O2/c25-22-16(11-19(14-26)28-24(30)23-17-3-4-18(12-17)27-23)2-1-15-13-20(5-6-21(15)22)29-7-9-31-10-8-29/h1-2,17-20,23,27H,3-13H2,(H,28,30)/t17-,18+,19-,20?,23-/m0/s1 AOFGEIPQRRXJES-AJOPTGRPSA-N 150677 US10238633, Example 351::US8987249, 351::US9713606, 351 Dipeptidyl peptidase 1 82.8 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150677&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430878 252824928 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732752 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCC2COCC2C1 InChI=1S/C23H29FN4O2/c24-21-9-20(28-6-5-16-12-30-13-17(16)11-28)4-2-14(21)7-19(10-25)27-23(29)22-15-1-3-18(8-15)26-22/h2,4,9,15-19,22,26H,1,3,5-8,11-13H2,(H,27,29)/t15-,16?,17?,18+,19-,22-/m0/s1 FJQGLLQSIMRVNW-MBJMIVNXSA-N 150678 US10238633, Example 352::US8987249, 352::US9713606, 352 Dipeptidyl peptidase 1 17.3 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150678&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430832 252824929 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732753 CN1CC2CCN(C2C1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H30FN5O/c1-28-12-16-6-7-29(21(16)13-28)19-5-3-14(20(24)10-19)8-18(11-25)27-23(30)22-15-2-4-17(9-15)26-22/h3,5,10,15-18,21-22,26H,2,4,6-9,12-13H2,1H3,(H,27,30)/t15-,16?,17+,18-,21?,22-/m0/s1 HEZSCOPWBZQUPX-CHXWQNPLSA-N 150679 US10238633, Example 353::US8987249, 353::US9713606, 353 Dipeptidyl peptidase 1 6.50 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150679&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430880 252824930 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732754 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCC2CN(CC12)C1CCOC1 InChI=1S/C26H34FN5O2/c27-23-11-21(32-7-5-18-13-31(14-24(18)32)22-6-8-34-15-22)4-2-16(23)9-20(12-28)30-26(33)25-17-1-3-19(10-17)29-25/h2,4,11,17-20,22,24-25,29H,1,3,5-10,13-15H2,(H,30,33)/t17-,18?,19+,20-,22?,24?,25-/m0/s1 FUQCVQPIQCQUJA-QOCJVYAVSA-N 150680 US10238633, Example 354::US8987249, 354::US9713606, 354 Dipeptidyl peptidase 1 6.80 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150680&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430818 252824931 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732755 CN1CCO[C@@H]2CN(C[C@H]12)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H30FN5O2/c1-28-6-7-31-21-13-29(12-20(21)28)18-5-3-14(19(24)10-18)8-17(11-25)27-23(30)22-15-2-4-16(9-15)26-22/h3,5,10,15-17,20-22,26H,2,4,6-9,12-13H2,1H3,(H,27,30)/t15-,16+,17-,20-,21+,22-/m0/s1 CQSOXMZXLHYZJS-MNJVBOLNSA-N 150681 US10238633, Example 355::US8987249, 355::US9713606, 355 Dipeptidyl peptidase 1 22.4 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150681&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430475 252824932 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732756 CN1CCO[C@@H]2CCN(C[C@H]12)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H32FN5O2/c1-29-8-9-32-22-6-7-30(14-21(22)29)19-5-3-15(20(25)12-19)10-18(13-26)28-24(31)23-16-2-4-17(11-16)27-23/h3,5,12,16-18,21-23,27H,2,4,6-11,14H2,1H3,(H,28,31)/t16-,17+,18-,21-,22+,23-/m0/s1 KTZQFVFLNYISOX-YNGMKWAISA-N 150682 US10238633, Example 356::US8987249, 356::US9713606, 356 Dipeptidyl peptidase 1 20.0 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150682&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430477 252824933 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732757 CN1CCO[C@H]2CN(CC[C@H]12)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C24H32FN5O2/c1-29-8-9-32-22-14-30(7-6-21(22)29)19-5-3-15(20(25)12-19)10-18(13-26)28-24(31)23-16-2-4-17(11-16)27-23/h3,5,12,16-18,21-23,27H,2,4,6-11,14H2,1H3,(H,28,31)/t16-,17+,18-,21-,22-,23-/m0/s1 LULCUNUDANTJSG-FVOHPSJWSA-N 150683 US10238633, Example 357::US8987249, 357::US9713606, 357 Dipeptidyl peptidase 1 33.8 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150683&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430480 252824934 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732758 CN1CCC2(CC(C2)c2ccc(C[C@H](NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)c(F)c2)CC1 InChI=1S/C25H33FN4O/c1-30-8-6-25(7-9-30)13-19(14-25)16-2-3-17(22(26)12-16)10-21(15-27)29-24(31)23-18-4-5-20(11-18)28-23/h2-3,12,18-21,23,28H,4-11,13-14H2,1H3,(H,29,31)/t18-,20+,21-,23-/m0/s1 VYUWIIULBHZCOM-SQMWVJLWSA-N 150684 US10238633, Example 358::US8987249, 358::US9713606, 358 Dipeptidyl peptidase 1 22.0 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150684 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150684&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430208 252824935 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732759 CN1CCC2(CC(=C2)c2ccc(C[C@H](NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)c(F)c2)CC1 InChI=1S/C25H31FN4O/c1-30-8-6-25(7-9-30)13-19(14-25)16-2-3-17(22(26)12-16)10-21(15-27)29-24(31)23-18-4-5-20(11-18)28-23/h2-3,12-13,18,20-21,23,28H,4-11,14H2,1H3,(H,29,31)/t18-,20+,21-,23-/m0/s1 CVDOMISMJVCMHM-SQMWVJLWSA-N 150685 US10238633, Example 359::US8987249, 359::US9713606, 359 Dipeptidyl peptidase 1 8.80 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150685 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150685&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90430211 252824936 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732402 CN1Cc2ccc(cc2C1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C25H27FN4O/c1-30-13-19-5-3-15(8-20(19)14-30)16-2-4-17(23(26)11-16)9-22(12-27)29-25(31)24-18-6-7-21(10-18)28-24/h2-5,8,11,18,21-22,24,28H,6-7,9-10,13-14H2,1H3,(H,29,31)/t18-,21+,22-,24-/m0/s1 GQBRPHSHOCUJAG-ASLXYRGWSA-N 150327 US10238633, Example 1::US8987249, 1::US9713606, 1 Dipeptidyl peptidase 1 8.60 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150327 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150327&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90414082 252824578 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732403 CN1C(=O)Cc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C25H25FN4O2/c1-30-22-11-15(3-5-17(22)12-23(30)31)14-2-4-16(21(26)10-14)8-20(13-27)29-25(32)24-18-6-7-19(9-18)28-24/h2-5,10-11,18-20,24,28H,6-9,12H2,1H3,(H,29,32)/t18-,19+,20-,24-/m0/s1 MNEOBAAFLAQMKF-VKDGWMQASA-N 150328 US10238633, Example 2::US8987249, 2::US9713606, 2 Dipeptidyl peptidase 1 2.00 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150328 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150328&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90414333 252824579 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732404 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2C(=O)OCc2c1 InChI=1S/C24H22FN3O3/c25-21-10-14(13-4-6-20-17(7-13)12-31-24(20)30)1-2-15(21)8-19(11-26)28-23(29)22-16-3-5-18(9-16)27-22/h1-2,4,6-7,10,16,18-19,22,27H,3,5,8-9,12H2,(H,28,29)/t16-,18+,19-,22-/m0/s1 WTHQKFUPVXDWIU-ZBPHCFQXSA-N 150329 US10238633, Example 3::US8987249, 3::US9713606, 3 Dipeptidyl peptidase 1 0.700 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150329 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150329&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90413943 252824580 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732405 CS(=O)(=O)c1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C23H24FN3O3S/c1-31(29,30)20-4-2-3-14(11-20)15-5-6-16(21(24)12-15)9-19(13-25)27-23(28)22-17-7-8-18(10-17)26-22/h2-6,11-12,17-19,22,26H,7-10H2,1H3,(H,27,28)/t17-,18+,19-,22-/m0/s1 SLANNUBDKTXJNP-WEMPKCCASA-N 150330 US10238633, Example 4::US8987249, 4::US9713606, 4 Dipeptidyl peptidase 1 1.40 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=150330 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=150330&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90415865 252824581 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 732406 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-n1cc(nn1)-c1ccc2[nH]ccc2c1 263576 US10238633, Example 5::US9713606, 5 Dipeptidyl peptidase 1 4.00 US Patent 10.7270/Q22R3TZF aid1798121 US10238633 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263576 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263576&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 90413568 377002480 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 768552 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)[C@@H]1CNCCCO1 InChI=1S/C22H22N4O2/c23-13-17-4-8-19(9-5-17)18-6-2-16(3-7-18)12-20(14-24)26-22(27)21-15-25-10-1-11-28-21/h2-9,20-21,25H,1,10-12,15H2,(H,26,27)/t20-,21-/m0/s1 FCRODBUNBQJNPU-SFTDATJTSA-N 50195236 CHEMBL3927609::US10287258, Example 1::US10669245, Example 1::US11117874, Example 1::US11673871, Example 34::US11680049, Example 1 Dipeptidyl peptidase 1 35.5 US Patent 10.7270/Q2RJ4MTP aid1798621 US10287258 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195236&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253857 375977091 CHEMBL3927609 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 768553 Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H24N4O4/c1-27-19-12-17(7-8-20(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)21-14-25-9-2-10-30-21/h3-8,12,18,21,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,21-/m0/s1 AEXFXNFMSAAELR-RXVVDRJESA-N 50195235 CHEMBL3900409::US10287258, Example 2::US10669245, Example 2::US11117874, Example 2::US11655221, Example 2::US11680049, Example 2 Dipeptidyl peptidase 1 4.47 US Patent 10.7270/Q2RJ4MTP aid1798621 US10287258 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195235&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253852 375977090 CHEMBL3900409 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 768554 Cc1cc(cc2n(C)c(=O)oc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H26N4O4/c1-15-10-18(12-20-22(15)32-24(30)28(20)2)17-6-4-16(5-7-17)11-19(13-25)27-23(29)21-14-26-8-3-9-31-21/h4-7,10,12,19,21,26H,3,8-9,11,14H2,1-2H3,(H,27,29)/t19-,21-/m0/s1 WCWJGAFMGPMBQG-FPOVZHCZSA-N 50195240 CHEMBL3960432::US10287258, Example 3::US10669245, Example 3::US11117874, Example 3::US11655221, Example 3::US11680049, Example 3 Dipeptidyl peptidase 1 10.2 US Patent 10.7270/Q2RJ4MTP aid1798621 US10287258 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195240&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253824 375977095 CHEMBL3960432 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 768555 CS(=O)(=O)Oc1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C22H25N3O5S/c1-31(27,28)30-20-5-2-4-18(13-20)17-8-6-16(7-9-17)12-19(14-23)25-22(26)21-15-24-10-3-11-29-21/h2,4-9,13,19,21,24H,3,10-12,15H2,1H3,(H,25,26)/t19-,21-/m0/s1 IRYUDRJLDSHZAO-FPOVZHCZSA-N 385044 4′-[(2S)-2-Cyano-2-{[(2S)-1,4-oxazepan-2-ylcarbonyl]amino}ethyl]biphenyl-3-yl methanesulfonate::US10287258, Example 4::US10669245, Example 4::US11117874, Example 4::US11667615, Example 4::US11680049, Example 4 Dipeptidyl peptidase 1 79.4 US Patent 10.7270/Q2RJ4MTP aid1798621 US10287258 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385044&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253891 404854267 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 768556 Cc1noc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H24N4O3/c1-15-20-12-18(7-8-21(20)30-27-15)17-5-3-16(4-6-17)11-19(13-24)26-23(28)22-14-25-9-2-10-29-22/h3-8,12,19,22,25H,2,9-11,14H2,1H3,(H,26,28)/t19-,22-/m0/s1 QCTYSVBOKIUUFU-UGKGYDQZSA-N 50195245 CHEMBL3972158::US10287258, Example 5::US10669245, Example 5::US11117874, Example 5::US11655221, Example 5::US11680049, Example 5 Dipeptidyl peptidase 1 16.2 US Patent 10.7270/Q2RJ4MTP aid1798621 US10287258 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195245 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195245&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253855 375977100 CHEMBL3972158 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 768557 FC(F)(F)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C22H22F3N3O2/c23-22(24,25)18-8-6-17(7-9-18)16-4-2-15(3-5-16)12-19(13-26)28-21(29)20-14-27-10-1-11-30-20/h2-9,19-20,27H,1,10-12,14H2,(H,28,29)/t19-,20-/m0/s1 USBDHHJQNTYSNJ-PMACEKPBSA-N 50195255 CHEMBL3945475::US10287258, Example 6::US10669245, Example 6::US11117874, Example 6::US11655221, Example 6::US11680049, Example 6 Dipeptidyl peptidase 1 36.3 US Patent 10.7270/Q2RJ4MTP aid1798621 US10287258 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195255 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195255&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253859 375977110 CHEMBL3945475 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 768558 Fc1ccc(cc1F)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C21H21F2N3O2/c22-18-7-6-16(11-19(18)23)15-4-2-14(3-5-15)10-17(12-24)26-21(27)20-13-25-8-1-9-28-20/h2-7,11,17,20,25H,1,8-10,13H2,(H,26,27)/t17-,20-/m0/s1 HSWVIXGRFREZJG-PXNSSMCTSA-N 385047 (2S)-N-[(1S)-1-Cyano-2-(3',4'-difluorobiphenyl-4-yl)ethyl]-1,4-oxazepane-2- carboxamide::US10287258, Example 7::US10669245, Example 7::US11117874, Example 7::US11655221, Example 7::US11667615, Example 7::US11680049, Example 7 Dipeptidyl peptidase 1 69.2 US Patent 10.7270/Q2RJ4MTP aid1798621 US10287258 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385047&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253829 404854270 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 768559 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(nc1)C#N)C#N)[C@@H]1CNCCCO1 InChI=1S/C21H21N5O2/c22-11-18-7-6-17(13-25-18)16-4-2-15(3-5-16)10-19(12-23)26-21(27)20-14-24-8-1-9-28-20/h2-7,13,19-20,24H,1,8-10,14H2,(H,26,27)/t19-,20-/m0/s1 UZXVZQQAOVNOKG-PMACEKPBSA-N 385048 (2S)-N-{(1S)-1-Cyano-2-[4-(6-cyanopyridin-3-yl)phenyl]ethyl}-1,4-oxazepane-2- carboxamide::US10287258, Example 8::US10669245, Example 8::US11117874, Example 8::US11655221, Example 8::US11667615, Example 8::US11680049, Example 8 Dipeptidyl peptidase 1 87.1 US Patent 10.7270/Q2RJ4MTP aid1798621 US10287258 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385048&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253853 404854271 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 768560 CN1C(=O)CSc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H26N4O3S/c1-28-20-12-18(7-8-22(20)32-15-23(28)29)17-5-3-16(4-6-17)11-19(13-25)27-24(30)21-14-26-9-2-10-31-21/h3-8,12,19,21,26H,2,9-11,14-15H2,1H3,(H,27,30)/t19-,21-/m0/s1 NSLGCWMFHWURGT-FPOVZHCZSA-N 385049 (2S)-N-{(1S)-1-Cyano-2-[4-(4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzothiazin-6- yl)phenyl]ethyl}-1,4-oxazepane-2-carboxamide::US10287258, Example 9::US10669245, Example 9::US11117874, Example 9::US11655221, Example 9::US11667615, Example 9::US11680049, Example 9 Dipeptidyl peptidase 1 12.9 US Patent 10.7270/Q2RJ4MTP aid1798621 US10287258 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385049&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253849 404854272 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 768561 CCn1c2cc(cc(C)c2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C25H28N4O4/c1-3-29-21-13-19(11-16(2)23(21)33-25(29)31)18-7-5-17(6-8-18)12-20(14-26)28-24(30)22-15-27-9-4-10-32-22/h5-8,11,13,20,22,27H,3-4,9-10,12,15H2,1-2H3,(H,28,30)/t20-,22-/m0/s1 ORHUZDNZRYZSJO-UNMCSNQZSA-N 385050 (2S)-N-{(1S)-1-Cyano-2-[4-(3-ethyl-7-methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-5- yl)phenyl]ethyl}-1,4-oxazepane-2-carboxamide::US10287258, Example 10::US10669245, Example 10::US11117874, Example 10::US11655221, Example 10::US11680049, Example 10 Dipeptidyl peptidase 1 21.4 US Patent 10.7270/Q2RJ4MTP aid1798621 US10287258 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385050&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253835 404854273 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 768562 CC(C)(O)Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C26H30N4O5/c1-26(2,33)16-30-21-13-19(8-9-22(21)35-25(30)32)18-6-4-17(5-7-18)12-20(14-27)29-24(31)23-15-28-10-3-11-34-23/h4-9,13,20,23,28,33H,3,10-12,15-16H2,1-2H3,(H,29,31)/t20-,23-/m0/s1 LRDOUIXCGZNESR-REWPJTCUSA-N 385051 (2S)-N-[(1S)-1-Cyano-2-{4-[3-(2-hydroxy-2-methylpropyl)-2-oxo-2,3-dihydro-1,3- benzoxazol-5-yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 11::US10669245, Example 11::US11117874, Example 11::US11655221, Example 11::US11667615, Example 11::US11680049, Example 11 Dipeptidyl peptidase 1 89.1 US Patent 10.7270/Q2RJ4MTP aid1798621 US10287258 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385051&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253819 404854274 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 768563 FC(F)Cn1c2cc(cc(F)c2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H23F3N4O4/c25-18-9-16(10-19-22(18)35-24(33)31(19)13-21(26)27)15-4-2-14(3-5-15)8-17(11-28)30-23(32)20-12-29-6-1-7-34-20/h2-5,9-10,17,20-21,29H,1,6-8,12-13H2,(H,30,32)/t17-,20-/m0/s1 PVRGXPYTNXSTMU-PXNSSMCTSA-N 385052 (2S)-N-[(1S)-1-Cyano-2-{4-[3-(2,2-difluoroethyl)-7-fluoro-2-oxo-2,3-dihydro-1,3- benzoxazol-5-yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 12::US10669245, Example 12::US11117874, Example 12::US11655221, Example 12::US11667615, Example 12::US11680049, Example 12 Dipeptidyl peptidase 1 10.0 US Patent 10.7270/Q2RJ4MTP aid1798621 US10287258 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385052&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253812 404854275 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 768564 CN(C)CCn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C26H31N5O4/c1-30(2)11-12-31-22-15-20(8-9-23(22)35-26(31)33)19-6-4-18(5-7-19)14-21(16-27)29-25(32)24-17-28-10-3-13-34-24/h4-9,15,21,24,28H,3,10-14,17H2,1-2H3,(H,29,32)/t21-,24-/m0/s1 BVHRFMZXVRJZAF-URXFXBBRSA-N 385053 (2S)-N-[(1S)-1-Cyano-2-(4-{3-[2-(dimethylamino)ethyl]-2-oxo-2,3-dihydro-1,3- benzoxazol-5-yl}pheny)ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 13::US10669245, Example 13::US11117874, Example 13::US11655221, Example 13::US11667615, Example 13::US11680049, Example 13 Dipeptidyl peptidase 1 7.24 US Patent 10.7270/Q2RJ4MTP aid1798621 US10287258 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385053&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253865 404854276 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 768565 CN1C(=O)C(F)(F)c2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H24F2N4O3/c1-30-20-12-17(7-8-19(20)24(25,26)23(30)32)16-5-3-15(4-6-16)11-18(13-27)29-22(31)21-14-28-9-2-10-33-21/h3-8,12,18,21,28H,2,9-11,14H2,1H3,(H,29,31)/t18-,21-/m0/s1 SABYNPLHFAPZQF-RXVVDRJESA-N 50195242 CHEMBL3917575::US10287258, Example 14::US10669245, Example 14::US11117874, Example 14::US11655221, Example 14::US11680049, Example 14 Dipeptidyl peptidase 1 16.6 US Patent 10.7270/Q2RJ4MTP aid1798621 US10287258 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195242&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253811 375977097 CHEMBL3917575 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 768566 Cn1c2cc(cc(F)c2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H23FN4O4/c1-28-19-11-16(10-18(24)21(19)32-23(28)30)15-5-3-14(4-6-15)9-17(12-25)27-22(29)20-13-26-7-2-8-31-20/h3-6,10-11,17,20,26H,2,7-9,13H2,1H3,(H,27,29)/t17-,20-/m0/s1 IVHOZTBKWBUDMJ-PXNSSMCTSA-N 385055 (2S)-N-{(1S)-1-Cyano-2-[4-(7-fluoro-3-methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-5- yl)phenyl]ethyl}-1,4-oxazepane-2-carboxamide::US10287258, Example 15::US10669245, Example 15::US11117874, Example 15::US11655221, Example 15::US11667615, Example 15::US11680049, Example 15 Dipeptidyl peptidase 1 5.13 US Patent 10.7270/Q2RJ4MTP aid1798621 US10287258 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385055&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253861 404854278 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 768567 CCn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H26N4O4/c1-2-28-20-13-18(8-9-21(20)32-24(28)30)17-6-4-16(5-7-17)12-19(14-25)27-23(29)22-15-26-10-3-11-31-22/h4-9,13,19,22,26H,2-3,10-12,15H2,1H3,(H,27,29)/t19-,22-/m0/s1 HZZYFVOLMKQYKP-UGKGYDQZSA-N 50195246 CHEMBL3980602::US10287258, Example 16::US10669245, Example 16::US11117874, Example 16::US11655221, Example 16 Dipeptidyl peptidase 1 5.75 US Patent 10.7270/Q2RJ4MTP aid1798621 US10287258 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195246 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195246&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253883 375977101 CHEMBL3980602 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 768568 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2oc(=O)n(CC3CC3)c2c1)C#N)[C@@H]1CNCCCO1 InChI=1S/C26H28N4O4/c27-14-21(29-25(31)24-15-28-10-1-11-33-24)12-17-4-6-19(7-5-17)20-8-9-23-22(13-20)30(26(32)34-23)16-18-2-3-18/h4-9,13,18,21,24,28H,1-3,10-12,15-16H2,(H,29,31)/t21-,24-/m0/s1 WJXGZWWSCFPECN-URXFXBBRSA-N 385057 (2S)-N-[(1S)-1-Cyano-2-{4-[3-(cyclopropylmethyl)-2-oxo-2,3-dihydro-1,3-benzoxazol- 5-yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 17::US10669245, Example 17::US11117874, Example 17::US11655221, Example 17::US11667615, Example 17::US11680049, Example 17 Dipeptidyl peptidase 1 6.31 US Patent 10.7270/Q2RJ4MTP aid1798621 US10287258 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385057&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253827 404854280 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 768569 COCCn1c2cc(ccc2sc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C25H28N4O4S/c1-32-12-10-29-21-14-19(7-8-23(21)34-25(29)31)18-5-3-17(4-6-18)13-20(15-26)28-24(30)22-16-27-9-2-11-33-22/h3-8,14,20,22,27H,2,9-13,16H2,1H3,(H,28,30)/t20-,22-/m0/s1 GRJJVLYWMJAVMA-UNMCSNQZSA-N 385058 (2S)-N-[(1S)-1-Cyano-2-{4-[3-(2-methoxyethyl)-2-oxo-2,3-dihydro-1,3-benzothiazol- 5-yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 18::US10669245, Example 18::US11117874, Example 18::US11655221, Example 18::US11667615, Example 18::US11680049, Example 18 Dipeptidyl peptidase 1 3.16 US Patent 10.7270/Q2RJ4MTP aid1798621 US10287258 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385058&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253842 404854281 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 768570 CC(C)n1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C25H28N4O4/c1-16(2)29-21-13-19(8-9-22(21)33-25(29)31)18-6-4-17(5-7-18)12-20(14-26)28-24(30)23-15-27-10-3-11-32-23/h4-9,13,16,20,23,27H,3,10-12,15H2,1-2H3,(H,28,30)/t20-,23-/m0/s1 WOBKXJRTDASPHQ-REWPJTCUSA-N 385059 (2S)-N- [(1S)-1-Cyano-2-{4-[2-oxo-3-(propan-2-yl)-2,3-dihydro-1,3-benzoxazol-5- yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 19::US10669245, Example 19::US11117874, Example 19::US11655221, Example 19::US11667615, Example 19::US11680049, Example 19 Dipeptidyl peptidase 1 14.5 US Patent 10.7270/Q2RJ4MTP aid1798621 US10287258 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385059&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253878 404854282 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 768571 CN1C(=O)COc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H26N4O4/c1-28-20-12-18(7-8-21(20)32-15-23(28)29)17-5-3-16(4-6-17)11-19(13-25)27-24(30)22-14-26-9-2-10-31-22/h3-8,12,19,22,26H,2,9-11,14-15H2,1H3,(H,27,30)/t19-,22-/m0/s1 QKDQSHLZLZUQOA-UGKGYDQZSA-N 50195238 CHEMBL3962926::US10287258, Example 20::US10669245, Example 20::US11117874, Example 20::US11655221, Example 20::US11680049, Example 20 Dipeptidyl peptidase 1 12.6 US Patent 10.7270/Q2RJ4MTP aid1798621 US10287258 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195238 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195238&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253870 375977093 CHEMBL3962926 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 768572 COCCn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C25H28N4O5/c1-32-12-10-29-21-14-19(7-8-22(21)34-25(29)31)18-5-3-17(4-6-18)13-20(15-26)28-24(30)23-16-27-9-2-11-33-23/h3-8,14,20,23,27H,2,9-13,16H2,1H3,(H,28,30)/t20-,23-/m0/s1 JUXOTDAODWSCQS-REWPJTCUSA-N 385061 (2S)-N-[(1S)-1-Cyano-2-{4-[3-(2-methoxyethyl)-2-oxo-2,3-dihydro-1,3-benzoxazol-5- yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 21::US10669245, Example 21::US11117874, Example 21::US11655221, Example 21::US11667615, Example 21::US11680049, Example 21 Dipeptidyl peptidase 1 8.13 US Patent 10.7270/Q2RJ4MTP aid1798621 US10287258 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385061&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253879 404854284 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 768573 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(s1)C#N)C#N)[C@@H]1CNCCCO1 InChI=1S/C20H20N4O2S/c21-11-16(24-20(25)18-13-23-8-1-9-26-18)10-14-2-4-15(5-3-14)19-7-6-17(12-22)27-19/h2-7,16,18,23H,1,8-10,13H2,(H,24,25)/t16-,18-/m0/s1 AYKAKRZDQIFHMD-WMZOPIPTSA-N 385062 (2S)-N-{(1S)-1-Cyano-2-[4-(5-cyanothiophen-2-yl)phenyl]ethyl}-1,4-oxazepane-2- carboxamide::US10287258, Example 22::US10669245, Example 22::US11117874, Example 22::US11655221, Example 22::US11667615, Example 22::US11680049, Example 22 Dipeptidyl peptidase 1 19.5 US Patent 10.7270/Q2RJ4MTP aid1798621 US10287258 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385062&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253837 404854285 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 768574 NC(=O)c1ccc(cc1F)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C22H23FN4O3/c23-19-11-16(6-7-18(19)21(25)28)15-4-2-14(3-5-15)10-17(12-24)27-22(29)20-13-26-8-1-9-30-20/h2-7,11,17,20,26H,1,8-10,13H2,(H2,25,28)(H,27,29)/t17-,20-/m0/s1 GCGGEFOSHQPZEX-PXNSSMCTSA-N 385063 (2S)-N-[(1S)-2-(4'-Carbamoy1-3'-fluorobiphenyl-4-yl)-1-cyanoethyl]-1,4-oxazepane-2- carboxamide::US10287258, Example 23::US10669245, Example 23::US11117874, Example 23::US11655221, Example 23::US11667615, Example 23::US11680049, Example 23 Dipeptidyl peptidase 1 67.6 US Patent 10.7270/Q2RJ4MTP aid1798621 US10287258 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385063&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253894 404854286 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 768575 Cn1c2cc(ccc2ccc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C25H26N4O3/c1-29-22-14-20(8-7-19(22)9-10-24(29)30)18-5-3-17(4-6-18)13-21(15-26)28-25(31)23-16-27-11-2-12-32-23/h3-10,14,21,23,27H,2,11-13,16H2,1H3,(H,28,31)/t21-,23-/m0/s1 BQIZWZAQEICNDG-GMAHTHKFSA-N 50195244 CHEMBL3926554::US10287258, Example 24::US10669245, Example 24::US11117874, Example 24::US11655221, Example 24::US11680049, Example 24 Dipeptidyl peptidase 1 13.8 US Patent 10.7270/Q2RJ4MTP aid1798621 US10287258 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195244&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253851 375977099 CHEMBL3926554 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 768576 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2oc(=O)n(CC3CCOCC3)c2c1)C#N)[C@@H]1CNCCCO1 InChI=1S/C28H32N4O5/c29-16-23(31-27(33)26-17-30-10-1-11-36-26)14-19-2-4-21(5-3-19)22-6-7-25-24(15-22)32(28(34)37-25)18-20-8-12-35-13-9-20/h2-7,15,20,23,26,30H,1,8-14,17-18H2,(H,31,33)/t23-,26-/m0/s1 KFOHIWSKADTAQW-OZXSUGGESA-N 385065 (2S)-N-[(1S)-1-Cyano-2-{4-[2-oxo-3-(tetrahydro-2H-pyran-4-ylmethyl)-2,3-dihydro- 1,3-benzoxazol-5-yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 25::US10669245, Example 25::US11117874, Example 25::US11655221, Example 25::US11667615, Example 25::US11680049, Example 25 Dipeptidyl peptidase 1 10.7 US Patent 10.7270/Q2RJ4MTP aid1798621 US10287258 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385065&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253876 404854288 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 768577 Cn1c2cc(cc(Cl)c2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H23ClN4O4/c1-28-19-11-16(10-18(24)21(19)32-23(28)30)15-5-3-14(4-6-15)9-17(12-25)27-22(29)20-13-26-7-2-8-31-20/h3-6,10-11,17,20,26H,2,7-9,13H2,1H3,(H,27,29)/t17-,20-/m0/s1 KTGYWWMCWUTXTI-PXNSSMCTSA-N 385066 (2S)-N-{(1S)-2-[4-(7-Chloro-3-methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)phenyl]- 1-cyanoethyl}-1,4-oxazepane-2-carboxamide::US10287258, Example 26::US10669245, Example 26::US11117874, Example 26::US11655221, Example 26::US11667615, Example 26::US11680049, Example 26 Dipeptidyl peptidase 1 13.5 US Patent 10.7270/Q2RJ4MTP aid1798621 US10287258 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385066&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253874 404854289 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 768578 FC(F)Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H24F2N4O4/c25-22(26)14-30-19-11-17(6-7-20(19)34-24(30)32)16-4-2-15(3-5-16)10-18(12-27)29-23(31)21-13-28-8-1-9-33-21/h2-7,11,18,21-22,28H,1,8-10,13-14H2,(H,29,31)/t18-,21-/m0/s1 ANPJTTUBCRFBKA-RXVVDRJESA-N 50195248 CHEMBL3891374::US10287258, Example 27::US10669245, Example 27::US11117874, Example 27::US11655221, Example 27::US11680049, Example 27 Dipeptidyl peptidase 1 6.61 US Patent 10.7270/Q2RJ4MTP aid1798621 US10287258 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195248 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195248&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253888 375977103 CHEMBL3891374 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 768579 FC(F)(F)Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H23F3N4O4/c25-24(26,27)14-31-19-11-17(6-7-20(19)35-23(31)33)16-4-2-15(3-5-16)10-18(12-28)30-22(32)21-13-29-8-1-9-34-21/h2-7,11,18,21,29H,1,8-10,13-14H2,(H,30,32)/t18-,21-/m0/s1 KAGSLWGZQVTFPB-RXVVDRJESA-N 385068 (2S)-N-[(1S)-1-Cyano-2-{4-[2-oxo-3-(2,2,2-trifluoroethyl)-2,3-dihydro-1,3- benzoxazol-5-yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 28::US10669245, Example 28::US11117874, Example 28::US11655221, Example 28::US11667615, Example 28::US11680049, Example 28 Dipeptidyl peptidase 1 8.13 US Patent 10.7270/Q2RJ4MTP aid1798621 US10287258 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385068&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253867 404854291 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 768580 Cn1c2cc(ccc2sc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H24N4O3S/c1-27-19-12-17(7-8-21(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)20-14-25-9-2-10-30-20/h3-8,12,18,20,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,20-/m0/s1 DRQDONWWFWYTII-ICSRJNTNSA-N 50195239 CHEMBL3972563::US10287258, Example 29::US10669245, Example 29::US11117874, Example 29::US11655221, Example 29::US11680049, Example 29 Dipeptidyl peptidase 1 2.40 US Patent 10.7270/Q2RJ4MTP aid1798621 US10287258 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195239&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91826235 375977094 CHEMBL3972563 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 768581 CS(=O)(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C22H25N3O4S/c1-30(27,28)20-9-7-18(8-10-20)17-5-3-16(4-6-17)13-19(14-23)25-22(26)21-15-24-11-2-12-29-21/h3-10,19,21,24H,2,11-13,15H2,1H3,(H,25,26)/t19-,21-/m0/s1 UBRDXNDHEGQOTI-FPOVZHCZSA-N 385070 (2S)-N-{(1S)-1-Cyano-2-[4'-(methylsulfonyl)bipheny1-4-yl]ethyl}-1,4-oxazepane-2- carboxamide::US10287258, Example 30::US10669245, Example 30::US11117874, Example 30::US11655221, Example 30::US11667615, Example 30::US11680049, Example 30 Dipeptidyl peptidase 1 37.2 US Patent 10.7270/Q2RJ4MTP aid1798621 US10287258 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385070&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253895 404854293 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 768582 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N1CCC1)C#N)[C@@H]1CNCCCO1 InChI=1S/C24H28N4O4S/c25-16-21(27-24(29)23-17-26-11-1-14-32-23)15-18-3-5-19(6-4-18)20-7-9-22(10-8-20)33(30,31)28-12-2-13-28/h3-10,21,23,26H,1-2,11-15,17H2,(H,27,29)/t21-,23-/m0/s1 CBWWXOUBSQCMHB-GMAHTHKFSA-N 385071 (2S)-N-{(1S)-2-[4'-(Azetidin-1-ylsulfonyl)biphenyl-4-yl]-1-cyanoethyl}-1,4-oxazepane- 2-carboxamide::US10287258, Example 31::US10669245, Example 31::US11117874, Example 31::US11655221, Example 31::US11667615, Example 31::US11680049, Example 31 Dipeptidyl peptidase 1 21.4 US Patent 10.7270/Q2RJ4MTP aid1798621 US10287258 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385071&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253890 404854294 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 768583 Fc1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C21H22FN3O2/c22-18-8-6-17(7-9-18)16-4-2-15(3-5-16)12-19(13-23)25-21(26)20-14-24-10-1-11-27-20/h2-9,19-20,24H,1,10-12,14H2,(H,25,26)/t19-,20-/m0/s1 PYXGGJVWIVBQRO-PMACEKPBSA-N 385072 (2S)-N-[(1S)-1-Cyano-2-(4'-fluorobiphenyl-4-yl)ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 32::US10669245, Example 32::US11117874, Example 32::US11655221, Example 32::US11667615, Example 32::US11680049, Example 32 Dipeptidyl peptidase 1 42.7 US Patent 10.7270/Q2RJ4MTP aid1798621 US10287258 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385072&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253858 404854295 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 768584 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2scnc2c1)C#N)[C@@H]1CNCCCO1 InChI=1S/C22H22N4O2S/c23-12-18(26-22(27)20-13-24-8-1-9-28-20)10-15-2-4-16(5-3-15)17-6-7-21-19(11-17)25-14-29-21/h2-7,11,14,18,20,24H,1,8-10,13H2,(H,26,27)/t18-,20-/m0/s1 MUTKXUKCDAFWLB-ICSRJNTNSA-N 50195263 CHEMBL3942969::US10287258, Example 33::US10669245, Example 33::US11117874, Example 33::US11673871, Example 33::US11680049, Example 33 Dipeptidyl peptidase 1 61.7 US Patent 10.7270/Q2RJ4MTP aid1798621 US10287258 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195263&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253877 375977118 CHEMBL3942969 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 768585 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)C1CNCCCO1 InChI=1S/C22H22N4O2/c23-13-17-4-8-19(9-5-17)18-6-2-16(3-7-18)12-20(14-24)26-22(27)21-15-25-10-1-11-28-21/h2-9,20-21,25H,1,10-12,15H2,(H,26,27)/t20-,21?/m0/s1 FCRODBUNBQJNPU-BGERDNNASA-N 385074 US10287258, Example 34::US10669245, Example 34::US11117874, Example 34::US11667615, Example 34::US11680049, Example 34 Dipeptidyl peptidase 1 60.3 US Patent 10.7270/Q2RJ4MTP aid1798621 US10287258 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385074&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118260121 404854297 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 768586 CN1C(=O)CNc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H27N5O3/c1-29-21-12-18(7-8-20(21)27-15-23(29)30)17-5-3-16(4-6-17)11-19(13-25)28-24(31)22-14-26-9-2-10-32-22/h3-8,12,19,22,26-27H,2,9-11,14-15H2,1H3,(H,28,31)/t19-,22-/m0/s1 CPBDCTBYFQTDMV-UGKGYDQZSA-N 385075 US10287258, Example 35::US10669245, Example 35::US11117874, Example 35::US11673871, Example 35::US11680049, Example 35 Dipeptidyl peptidase 1 24.5 US Patent 10.7270/Q2RJ4MTP aid1798621 US10287258 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385075&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253822 404854298 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 768587 CC[C@H](NC(=O)[C@@H]1CNCCCO1)\C=C\C(=O)N1CCc2ccccc12 InChI=1S/C20H27N3O3/c1-2-16(22-20(25)18-14-21-11-5-13-26-18)8-9-19(24)23-12-10-15-6-3-4-7-17(15)23/h3-4,6-9,16,18,21H,2,5,10-14H2,1H3,(H,22,25)/b9-8+/t16-,18-/m0/s1 OHNHQTNQBQMALV-LFGVRAQPSA-N 385076 BDBM445984::US10287258, Example 36::US11667615, Example 36::US11680049, Example 36 Dipeptidyl peptidase 1 5.01 US Patent 10.7270/Q2RJ4MTP aid1798622 US10287258 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385076&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 144891673 404854299 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 768588 CC(C)C[C@H](NC(=O)[C@@H]1CNCCCO1)\C=C\C(=O)N1CCc2ccccc12 InChI=1S/C22H31N3O3/c1-16(2)14-18(24-22(27)20-15-23-11-5-13-28-20)8-9-21(26)25-12-10-17-6-3-4-7-19(17)25/h3-4,6-9,16,18,20,23H,5,10-15H2,1-2H3,(H,24,27)/b9-8+/t18-,20+/m1/s1 PXFMGAFAIVURSO-ZZHWGSSASA-N 385077 BDBM445985::US10287258, Example 37::US11667615, Example 37::US11680049, Example 37 Dipeptidyl peptidase 1 5.25 US Patent 10.7270/Q2RJ4MTP aid1798622 US10287258 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385077&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 144891689 404854300 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 828403 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2COC3(CCN(CC3)C3COC3)c2c1 InChI=1S/C31H35FN4O3/c32-28-14-20(1-3-21(28)11-25(15-33)35-30(37)29-22-5-6-24(12-22)34-29)19-2-4-23-16-39-31(27(23)13-19)7-9-36(10-8-31)26-17-38-18-26/h1-4,13-14,22,24-26,29,34H,5-12,16-18H2,(H,35,37)/t22-,24+,25-,29-/m0/s1 MIBKKDLVBYJWTB-AIKBEYBBSA-N 201012 US9540373, 1::US9879026, Example 1::USRE47636, Example 1 Dipeptidyl peptidase 1 1.10 US Patent 10.7270/Q27D2XG4 aid1803866 USRE47636 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201012&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118939917 375976336 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 828404 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2CCC3(CCNCC3)c2c1 InChI=1S/C29H33FN4O/c30-26-16-20(19-2-1-18-7-8-29(25(18)15-19)9-11-32-12-10-29)3-4-21(26)13-24(17-31)34-28(35)27-22-5-6-23(14-22)33-27/h1-4,15-16,22-24,27,32-33H,5-14H2,(H,34,35)/t22-,23+,24-,27-/m0/s1 DSRUXRRIDSZAIA-LAOBSVPGSA-N 201013 US9540373, 2::US9879026, Example 2::USRE47636, Example 2 Dipeptidyl peptidase 1 0.600 US Patent 10.7270/Q27D2XG4 aid1803866 USRE47636 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201013&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184937 375976337 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 828405 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2NC(=O)C3(CCNCC3)c2c1 InChI=1S/C28H30FN5O2/c29-23-14-17(16-4-6-24-22(13-16)28(27(36)34-24)7-9-31-10-8-28)1-2-18(23)11-21(15-30)33-26(35)25-19-3-5-20(12-19)32-25/h1-2,4,6,13-14,19-21,25,31-32H,3,5,7-12H2,(H,33,35)(H,34,36)/t19-,20+,21-,25-/m0/s1 WZYGEAFXJAOMCC-PDFGSZSQSA-N 201014 US9540373, 3::US9879026, Example 3::USRE47636, Example 3 Dipeptidyl peptidase 1 0.300 US Patent 10.7270/Q27D2XG4 aid1803866 USRE47636 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201014 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201014&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184938 375976338 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 828406 CN1C(=O)C2(CCNCC2)c2cc(ccc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C29H32FN5O2/c1-35-25-7-5-17(14-23(25)29(28(35)37)8-10-32-11-9-29)18-2-3-19(24(30)15-18)12-22(16-31)34-27(36)26-20-4-6-21(13-20)33-26/h2-3,5,7,14-15,20-22,26,32-33H,4,6,8-13H2,1H3,(H,34,36)/t20-,21+,22-,26-/m0/s1 CXEHWKQDWKZLQY-MSZDEVHKSA-N 201015 US9540373, 4::US9879026, Example 4::USRE47636, Example 4 Dipeptidyl peptidase 1 0.400 US Patent 10.7270/Q27D2XG4 aid1803866 USRE47636 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201015 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201015&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184939 375976339 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 828407 CN1C(=O)C2(CCN(C)CC2)c2cc(ccc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C30H34FN5O2/c1-35-11-9-30(10-12-35)24-15-18(6-8-26(24)36(2)29(30)38)19-3-4-20(25(31)16-19)13-23(17-32)34-28(37)27-21-5-7-22(14-21)33-27/h3-4,6,8,15-16,21-23,27,33H,5,7,9-14H2,1-2H3,(H,34,37)/t21-,22+,23-,27-/m0/s1 NFSMBZKEGKVOOI-GIRPNKPCSA-N 201016 US9540373, 5::US9879026, Example 5::USRE47636, Example 5 Dipeptidyl peptidase 1 0.600 US Patent 10.7270/Q27D2XG4 aid1803866 USRE47636 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201016&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184904 375976340 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 828408 CN1CCC2(CC1)C(=O)Nc1ccc(cc21)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C29H32FN5O2/c1-35-10-8-29(9-11-35)23-14-17(5-7-25(23)34-28(29)37)18-2-3-19(24(30)15-18)12-22(16-31)33-27(36)26-20-4-6-21(13-20)32-26/h2-3,5,7,14-15,20-22,26,32H,4,6,8-13H2,1H3,(H,33,36)(H,34,37)/t20-,21+,22-,26-/m0/s1 GANYKEOVXMYLES-MSZDEVHKSA-N 201017 US9540373, 6::US9879026, Example 6::USRE47636, Example 6 Dipeptidyl peptidase 1 0.200 US Patent 10.7270/Q27D2XG4 aid1803866 USRE47636 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201017&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184954 375976341 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 828409 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2C(=O)OC3(CCNCC3)c2c1 InChI=1S/C28H29FN4O3/c29-24-14-17(16-4-6-22-23(13-16)28(36-27(22)35)7-9-31-10-8-28)1-2-18(24)11-21(15-30)33-26(34)25-19-3-5-20(12-19)32-25/h1-2,4,6,13-14,19-21,25,31-32H,3,5,7-12H2,(H,33,34)/t19-,20+,21-,25-/m0/s1 ANLWAHOMUCKFHK-PDFGSZSQSA-N 201018 US9540373, 7::US9879026, Example 7::USRE47636, Example 7 Dipeptidyl peptidase 1 0.500 US Patent 10.7270/Q27D2XG4 aid1803866 USRE47636 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201018&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184955 375976342 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 828410 CN1CCC2(CC1)OC(=O)c1ccc(cc21)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C29H31FN4O3/c1-34-10-8-29(9-11-34)24-14-17(5-7-23(24)28(36)37-29)18-2-3-19(25(30)15-18)12-22(16-31)33-27(35)26-20-4-6-21(13-20)32-26/h2-3,5,7,14-15,20-22,26,32H,4,6,8-13H2,1H3,(H,33,35)/t20-,21+,22-,26-/m0/s1 HDXINRXLBDJTBO-MSZDEVHKSA-N 201019 US9540373, 8::US9879026, Example 8::USRE47636, Example 8 Dipeptidyl peptidase 1 0.700 US Patent 10.7270/Q27D2XG4 aid1803866 USRE47636 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201019 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201019&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184918 375976343 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 828411 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2C(=O)OC3(CCNC3)c2c1 InChI=1S/C27H27FN4O3/c28-23-12-16(15-4-6-21-22(11-15)27(35-26(21)34)7-8-30-14-27)1-2-17(23)9-20(13-29)32-25(33)24-18-3-5-19(10-18)31-24/h1-2,4,6,11-12,18-20,24,30-31H,3,5,7-10,14H2,(H,32,33)/t18-,19+,20-,24-,27?/m0/s1 IHLOZXJKAUYWCS-YRMZYPIJSA-N 201020 US9540373, 9::US9879026, Example 9::USRE47636, Example 9 Dipeptidyl peptidase 1 0.500 US Patent 10.7270/Q27D2XG4 aid1803866 USRE47636 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201020 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201020&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184927 375976344 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 828412 CN1CCC2(C1)OC(=O)c1ccc(cc21)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C28H29FN4O3/c1-33-9-8-28(15-33)23-12-16(5-7-22(23)27(35)36-28)17-2-3-18(24(29)13-17)10-21(14-30)32-26(34)25-19-4-6-20(11-19)31-25/h2-3,5,7,12-13,19-21,25,31H,4,6,8-11,15H2,1H3,(H,32,34)/t19-,20+,21-,25-,28?/m0/s1 GZDIEAVBMSLAOW-WWOCRAFXSA-N 201021 US9540373, 10::US9879026, Example 10::USRE47636, Example 10 Dipeptidyl peptidase 1 0.600 US Patent 10.7270/Q27D2XG4 aid1803866 USRE47636 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201021 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201021&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184917 375976345 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 828413 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2C(=O)OC3(CNC3)c2c1 InChI=1S/C26H25FN4O3/c27-22-10-15(14-4-6-20-21(9-14)26(12-29-13-26)34-25(20)33)1-2-16(22)7-19(11-28)31-24(32)23-17-3-5-18(8-17)30-23/h1-2,4,6,9-10,17-19,23,29-30H,3,5,7-8,12-13H2,(H,31,32)/t17-,18+,19-,23-/m0/s1 RZHGTZMOHTZJBI-YWNPBTLJSA-N 201022 US9540373, 11::US9879026, Example 11::USRE47636, Example 11 Dipeptidyl peptidase 1 0.700 US Patent 10.7270/Q27D2XG4 aid1803866 USRE47636 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201022 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201022&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184947 375976346 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 828414 CN1CC2(C1)OC(=O)c1ccc(cc21)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C27H27FN4O3/c1-32-13-27(14-32)22-10-15(5-7-21(22)26(34)35-27)16-2-3-17(23(28)11-16)8-20(12-29)31-25(33)24-18-4-6-19(9-18)30-24/h2-3,5,7,10-11,18-20,24,30H,4,6,8-9,13-14H2,1H3,(H,31,33)/t18-,19+,20-,24-/m0/s1 GWAYSZALTIDBDU-VKDGWMQASA-N 201023 US9540373, 12::US9879026, Example 12::USRE47636, Example 12 Dipeptidyl peptidase 1 0.500 US Patent 10.7270/Q27D2XG4 aid1803866 USRE47636 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201023&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184916 375976347 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 828415 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2COC3(CCNCC3)c2c1 InChI=1S/C28H31FN4O2/c29-25-14-18(17-2-4-21-16-35-28(24(21)13-17)7-9-31-10-8-28)1-3-19(25)11-23(15-30)33-27(34)26-20-5-6-22(12-20)32-26/h1-4,13-14,20,22-23,26,31-32H,5-12,16H2,(H,33,34)/t20-,22+,23-,26-/m0/s1 NGCHHBUOUZQOFZ-VBZBYZBJSA-N 201024 US9540373, 13::US9879026, Example 13::USRE47636, Example 13 Dipeptidyl peptidase 1 0.600 US Patent 10.7270/Q27D2XG4 aid1803866 USRE47636 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201024 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201024&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184898 375976348 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 828416 CN1CCC2(CC1)OCc1ccc(cc21)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C29H33FN4O2/c1-34-10-8-29(9-11-34)25-14-18(3-5-22(25)17-36-29)19-2-4-20(26(30)15-19)12-24(16-31)33-28(35)27-21-6-7-23(13-21)32-27/h2-5,14-15,21,23-24,27,32H,6-13,17H2,1H3,(H,33,35)/t21-,23+,24-,27-/m0/s1 LINMSXGSIPWEDG-DQHZSEARSA-N 201025 US9540373, 14::US9879026, Example 14::USRE47636, Example 14 Dipeptidyl peptidase 1 1.000 US Patent 10.7270/Q27D2XG4 aid1803866 USRE47636 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201025&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184899 375976349 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 828417 CN1CCC2(CCc3ccc(cc23)-c2ccc(C[C@H](NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)c(F)c2)CC1 InChI=1S/C30H35FN4O/c1-35-12-10-30(11-13-35)9-8-19-2-3-20(16-26(19)30)21-4-5-22(27(31)17-21)14-25(18-32)34-29(36)28-23-6-7-24(15-23)33-28/h2-5,16-17,23-25,28,33H,6-15H2,1H3,(H,34,36)/t23-,24+,25-,28-/m0/s1 QPILZBCBUNFEJW-GIBNYFNHSA-N 201026 US9540373, 15::US9879026, Example 15::USRE47636, Example 15 Dipeptidyl peptidase 1 0.500 US Patent 10.7270/Q27D2XG4 aid1803866 USRE47636 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201026&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184929 375976350 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 828418 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2NC(=O)C3(CCNC3)c2c1 InChI=1S/C27H28FN5O2/c28-22-12-16(15-4-6-23-21(11-15)27(26(35)33-23)7-8-30-14-27)1-2-17(22)9-20(13-29)32-25(34)24-18-3-5-19(10-18)31-24/h1-2,4,6,11-12,18-20,24,30-31H,3,5,7-10,14H2,(H,32,34)(H,33,35)/t18-,19+,20-,24-,27?/m0/s1 PPKDQAGFRUNTKU-YRMZYPIJSA-N 201027 US9540373, 16::US9879026, Example 16::USRE47636, Example 16 Dipeptidyl peptidase 1 0.500 US Patent 10.7270/Q27D2XG4 aid1803866 USRE47636 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201027&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184903 375976351 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 828419 CN1C(=O)C2(CCCN(C)C2)c2cc(ccc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C30H34FN5O2/c1-35-11-3-10-30(17-35)24-14-18(7-9-26(24)36(2)29(30)38)19-4-5-20(25(31)15-19)12-23(16-32)34-28(37)27-21-6-8-22(13-21)33-27/h4-5,7,9,14-15,21-23,27,33H,3,6,8,10-13,17H2,1-2H3,(H,34,37)/t21-,22+,23-,27-,30?/m0/s1 AAOICSZNQCRTDO-UALQKFLNSA-N 201028 US9540373, 17::US9879026, Example 17::USRE47636, Example 17 Dipeptidyl peptidase 1 1.60 US Patent 10.7270/Q27D2XG4 aid1803866 USRE47636 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201028&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184914 375976352 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 828420 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cc2c(cn1)C(=O)OC21CCNCC1 InChI=1S/C27H28FN5O3/c28-22-11-16(23-12-21-20(14-31-23)26(35)36-27(21)5-7-30-8-6-27)2-1-15(22)9-19(13-29)33-25(34)24-17-3-4-18(10-17)32-24/h1-2,11-12,14,17-19,24,30,32H,3-10H2,(H,33,34)/t17-,18+,19-,24-/m0/s1 SXKJOBWBROQYHC-YDLHNXBPSA-N 201029 US9540373, 18::US9879026, Example 18::USRE47636, Example 18 Dipeptidyl peptidase 1 1.60 US Patent 10.7270/Q27D2XG4 aid1803866 USRE47636 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201029&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184930 375976353 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 828421 CN1CCC2(CC1)OC(=O)c1cnc(cc21)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C28H30FN5O3/c1-34-8-6-28(7-9-34)22-13-24(31-15-21(22)27(36)37-28)17-3-2-16(23(29)12-17)10-20(14-30)33-26(35)25-18-4-5-19(11-18)32-25/h2-3,12-13,15,18-20,25,32H,4-11H2,1H3,(H,33,35)/t18-,19+,20-,25-/m0/s1 CLQRHMRHSRFUBH-ZDQHKECQSA-N 201030 US9540373, 19::US9879026, Example 19::USRE47636, Example 19 Dipeptidyl peptidase 1 1.000 US Patent 10.7270/Q27D2XG4 aid1803866 USRE47636 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201030&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184900 375976354 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 828422 CN1CCC2(C1)OC(=O)c1cnc(cc21)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C27H28FN5O3/c1-33-7-6-27(14-33)21-11-23(30-13-20(21)26(35)36-27)16-3-2-15(22(28)10-16)8-19(12-29)32-25(34)24-17-4-5-18(9-17)31-24/h2-3,10-11,13,17-19,24,31H,4-9,14H2,1H3,(H,32,34)/t17-,18+,19-,24-,27?/m0/s1 YZPZXQUEXBVKKM-IKHSKEIOSA-N 201031 US9540373, 20::US9879026, Example 20::USRE47636, Example 20 Dipeptidyl peptidase 1 1.60 US Patent 10.7270/Q27D2XG4 aid1803866 USRE47636 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201031&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184901 375976355 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 828423 CN1CCC2(CC1)OC(=O)c1ncc(cc21)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C28H30FN5O3/c1-34-8-6-28(7-9-34)22-12-19(15-31-25(22)27(36)37-28)16-2-3-17(23(29)13-16)10-21(14-30)33-26(35)24-18-4-5-20(11-18)32-24/h2-3,12-13,15,18,20-21,24,32H,4-11H2,1H3,(H,33,35)/t18-,20+,21-,24-/m0/s1 LQCCOFQTUNRXCK-UQWVPHONSA-N 201032 US9540373, 21::US9879026, Example 21::USRE47636, Example 21 Dipeptidyl peptidase 1 1.40 US Patent 10.7270/Q27D2XG4 aid1803866 USRE47636 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201032&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184956 375976356 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 828424 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cc2c(cn1)C(=O)OC21CCN(CC1)C1COC1 InChI=1S/C30H32FN5O4/c31-25-11-18(2-1-17(25)9-21(13-32)35-28(37)27-19-3-4-20(10-19)34-27)26-12-24-23(14-33-26)29(38)40-30(24)5-7-36(8-6-30)22-15-39-16-22/h1-2,11-12,14,19-22,27,34H,3-10,15-16H2,(H,35,37)/t19-,20+,21-,27-/m0/s1 JMHULBQBHVSKRL-WFQVPWNOSA-N 201033 US9540373, 22::US9879026, Example 22::USRE47636, Example 22 Dipeptidyl peptidase 1 4.80 US Patent 10.7270/Q27D2XG4 aid1803866 USRE47636 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201033&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184902 375976357 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 828425 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cc2c(COC22CCN(CC2)C2COC2)cn1 InChI=1S/C30H34FN5O3/c31-26-11-19(2-1-18(26)9-23(13-32)35-29(37)28-20-3-4-22(10-20)34-28)27-12-25-21(14-33-27)15-39-30(25)5-7-36(8-6-30)24-16-38-17-24/h1-2,11-12,14,20,22-24,28,34H,3-10,15-17H2,(H,35,37)/t20-,22+,23-,28-/m0/s1 VIDWRXWIFCHQDH-HQGMYGGFSA-N 201034 US9540373, 23::US9879026, Example 23::USRE47636, Example 23 Dipeptidyl peptidase 1 5.00 US Patent 10.7270/Q27D2XG4 aid1803866 USRE47636 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201034&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118939920 375976358 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 828426 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2C(=O)OC3(CCN(CC3)C3COC3)c2n1 InChI=1S/C30H32FN5O4/c31-24-13-18(2-1-17(24)11-21(14-32)34-28(37)26-19-3-4-20(12-19)33-26)25-6-5-23-27(35-25)30(40-29(23)38)7-9-36(10-8-30)22-15-39-16-22/h1-2,5-6,13,19-22,26,33H,3-4,7-12,15-16H2,(H,34,37)/t19-,20+,21-,26-/m0/s1 QDEUYXRXWLXIES-LMMUWCHVSA-N 201036 US9540373, 24::US9879026, Example 24::USRE47636, Example 24 Dipeptidyl peptidase 1 2.70 US Patent 10.7270/Q27D2XG4 aid1803866 USRE47636 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201036&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 124184892 375976359 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 828427 Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2COC3(CCN(CC3)C3COC3)c2n1 InChI=1S/C30H34FN5O3/c31-25-13-19(2-1-18(25)11-23(14-32)34-29(37)27-20-3-5-22(12-20)33-27)26-6-4-21-15-39-30(28(21)35-26)7-9-36(10-8-30)24-16-38-17-24/h1-2,4,6,13,20,22-24,27,33H,3,5,7-12,15-17H2,(H,34,37)/t20-,22+,23-,27-/m0/s1 DJEHFUIVWJPRCP-XUTUTRJZSA-N 201037 US9540373, 25::US9879026, Example 25::USRE47636, Example 25 Dipeptidyl peptidase 1 1.80 US Patent 10.7270/Q27D2XG4 aid1803866 USRE47636 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201037 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201037&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118939923 375976360 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 828428 CN1CCC2(CC1)OCc1cnc(cc21)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 InChI=1S/C28H32FN5O2/c1-34-8-6-28(7-9-34)23-13-25(31-15-20(23)16-36-28)18-3-2-17(24(29)12-18)10-22(14-30)33-27(35)26-19-4-5-21(11-19)32-26/h2-3,12-13,15,19,21-22,26,32H,4-11,16H2,1H3,(H,33,35)/t19-,21+,22-,26-/m0/s1 LPWVDJUWYBLVEL-IYCJUYGXSA-N 201549 US9540373, 26::US9879026, Example 26::USRE47636, Example 26 Dipeptidyl peptidase 1 2.00 US Patent 10.7270/Q27D2XG4 aid1803866 USRE47636 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201549 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201549&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118939916 375976361 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 828429 Fc1cc(ccc1C[C@H](NC(=O)C12CCC(CC1)CN2)C#N)-c1ccc2COC3(CCN(CC3)C3COC3)c2c1 InChI=1S/C32H37FN4O3/c33-29-15-23(1-3-24(29)13-26(16-34)36-30(38)31-7-5-21(6-8-31)17-35-31)22-2-4-25-18-40-32(28(25)14-22)9-11-37(12-10-32)27-19-39-20-27/h1-4,14-15,21,26-27,35H,5-13,17-20H2,(H,36,38)/t21?,26-,31?/m0/s1 VCBLPORJGXYQEJ-YVWBODOZSA-N 201550 US9540373, 27::US9879026, Example 27::USRE47636, Example 27 Dipeptidyl peptidase 1 2.90 US Patent 10.7270/Q27D2XG4 aid1803866 USRE47636 Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=201550 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=201550&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118939927 375976362 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1285084 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)[C@@H]1CNCCCO1 InChI=1S/C22H22N4O2/c23-13-17-4-8-19(9-5-17)18-6-2-16(3-7-18)12-20(14-24)26-22(27)21-15-25-10-1-11-28-21/h2-9,20-21,25H,1,10-12,15H2,(H,26,27)/t20-,21-/m0/s1 FCRODBUNBQJNPU-SFTDATJTSA-N 50195236 CHEMBL3927609::US10287258, Example 1::US10669245, Example 1::US11117874, Example 1::US11673871, Example 34::US11680049, Example 1 Dipeptidyl peptidase 1 35.5 US Patent 10.7270/Q2FB56W4 US11673871 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195236&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253857 375977091 CHEMBL3927609 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1285085 Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H24N4O4/c1-27-19-12-17(7-8-20(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)21-14-25-9-2-10-30-21/h3-8,12,18,21,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,21-/m0/s1 AEXFXNFMSAAELR-RXVVDRJESA-N 50195235 CHEMBL3900409::US10287258, Example 2::US10669245, Example 2::US11117874, Example 2::US11655221, Example 2::US11680049, Example 2 Dipeptidyl peptidase 1 4.47 US Patent 10.7270/Q2FB56W4 US11673871 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195235&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253852 375977090 CHEMBL3900409 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1285086 Cc1cc(cc2n(C)c(=O)oc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H26N4O4/c1-15-10-18(12-20-22(15)32-24(30)28(20)2)17-6-4-16(5-7-17)11-19(13-25)27-23(29)21-14-26-8-3-9-31-21/h4-7,10,12,19,21,26H,3,8-9,11,14H2,1-2H3,(H,27,29)/t19-,21-/m0/s1 WCWJGAFMGPMBQG-FPOVZHCZSA-N 50195240 CHEMBL3960432::US10287258, Example 3::US10669245, Example 3::US11117874, Example 3::US11655221, Example 3::US11680049, Example 3 Dipeptidyl peptidase 1 10.2 US Patent 10.7270/Q2FB56W4 US11673871 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195240&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253824 375977095 CHEMBL3960432 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1285087 CS(=O)(=O)Oc1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C22H25N3O5S/c1-31(27,28)30-20-5-2-4-18(13-20)17-8-6-16(7-9-17)12-19(14-23)25-22(26)21-15-24-10-3-11-29-21/h2,4-9,13,19,21,24H,3,10-12,15H2,1H3,(H,25,26)/t19-,21-/m0/s1 IRYUDRJLDSHZAO-FPOVZHCZSA-N 385044 4′-[(2S)-2-Cyano-2-{[(2S)-1,4-oxazepan-2-ylcarbonyl]amino}ethyl]biphenyl-3-yl methanesulfonate::US10287258, Example 4::US10669245, Example 4::US11117874, Example 4::US11667615, Example 4::US11680049, Example 4 Dipeptidyl peptidase 1 79.4 US Patent 10.7270/Q2FB56W4 US11673871 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385044&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253891 404854267 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1285088 Cc1noc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H24N4O3/c1-15-20-12-18(7-8-21(20)30-27-15)17-5-3-16(4-6-17)11-19(13-24)26-23(28)22-14-25-9-2-10-29-22/h3-8,12,19,22,25H,2,9-11,14H2,1H3,(H,26,28)/t19-,22-/m0/s1 QCTYSVBOKIUUFU-UGKGYDQZSA-N 50195245 CHEMBL3972158::US10287258, Example 5::US10669245, Example 5::US11117874, Example 5::US11655221, Example 5::US11680049, Example 5 Dipeptidyl peptidase 1 16.2 US Patent 10.7270/Q2FB56W4 US11673871 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195245 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195245&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253855 375977100 CHEMBL3972158 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1285089 FC(F)(F)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C22H22F3N3O2/c23-22(24,25)18-8-6-17(7-9-18)16-4-2-15(3-5-16)12-19(13-26)28-21(29)20-14-27-10-1-11-30-20/h2-9,19-20,27H,1,10-12,14H2,(H,28,29)/t19-,20-/m0/s1 USBDHHJQNTYSNJ-PMACEKPBSA-N 50195255 CHEMBL3945475::US10287258, Example 6::US10669245, Example 6::US11117874, Example 6::US11655221, Example 6::US11680049, Example 6 Dipeptidyl peptidase 1 36.3 US Patent 10.7270/Q2FB56W4 US11673871 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195255 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195255&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253859 375977110 CHEMBL3945475 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1285090 Fc1ccc(cc1F)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C21H21F2N3O2/c22-18-7-6-16(11-19(18)23)15-4-2-14(3-5-15)10-17(12-24)26-21(27)20-13-25-8-1-9-28-20/h2-7,11,17,20,25H,1,8-10,13H2,(H,26,27)/t17-,20-/m0/s1 HSWVIXGRFREZJG-PXNSSMCTSA-N 385047 (2S)-N-[(1S)-1-Cyano-2-(3',4'-difluorobiphenyl-4-yl)ethyl]-1,4-oxazepane-2- carboxamide::US10287258, Example 7::US10669245, Example 7::US11117874, Example 7::US11655221, Example 7::US11667615, Example 7::US11680049, Example 7 Dipeptidyl peptidase 1 69.2 US Patent 10.7270/Q2FB56W4 US11673871 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385047&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253829 404854270 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1285091 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(nc1)C#N)C#N)[C@@H]1CNCCCO1 InChI=1S/C21H21N5O2/c22-11-18-7-6-17(13-25-18)16-4-2-15(3-5-16)10-19(12-23)26-21(27)20-14-24-8-1-9-28-20/h2-7,13,19-20,24H,1,8-10,14H2,(H,26,27)/t19-,20-/m0/s1 UZXVZQQAOVNOKG-PMACEKPBSA-N 385048 (2S)-N-{(1S)-1-Cyano-2-[4-(6-cyanopyridin-3-yl)phenyl]ethyl}-1,4-oxazepane-2- carboxamide::US10287258, Example 8::US10669245, Example 8::US11117874, Example 8::US11655221, Example 8::US11667615, Example 8::US11680049, Example 8 Dipeptidyl peptidase 1 87.1 US Patent 10.7270/Q2FB56W4 US11673871 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385048&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253853 404854271 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1285092 CN1C(=O)CSc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H26N4O3S/c1-28-20-12-18(7-8-22(20)32-15-23(28)29)17-5-3-16(4-6-17)11-19(13-25)27-24(30)21-14-26-9-2-10-31-21/h3-8,12,19,21,26H,2,9-11,14-15H2,1H3,(H,27,30)/t19-,21-/m0/s1 NSLGCWMFHWURGT-FPOVZHCZSA-N 385049 (2S)-N-{(1S)-1-Cyano-2-[4-(4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzothiazin-6- yl)phenyl]ethyl}-1,4-oxazepane-2-carboxamide::US10287258, Example 9::US10669245, Example 9::US11117874, Example 9::US11655221, Example 9::US11667615, Example 9::US11680049, Example 9 Dipeptidyl peptidase 1 12.9 US Patent 10.7270/Q2FB56W4 US11673871 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385049&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253849 404854272 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1285093 CCn1c2cc(cc(C)c2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C25H28N4O4/c1-3-29-21-13-19(11-16(2)23(21)33-25(29)31)18-7-5-17(6-8-18)12-20(14-26)28-24(30)22-15-27-9-4-10-32-22/h5-8,11,13,20,22,27H,3-4,9-10,12,15H2,1-2H3,(H,28,30)/t20-,22-/m0/s1 ORHUZDNZRYZSJO-UNMCSNQZSA-N 385050 (2S)-N-{(1S)-1-Cyano-2-[4-(3-ethyl-7-methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-5- yl)phenyl]ethyl}-1,4-oxazepane-2-carboxamide::US10287258, Example 10::US10669245, Example 10::US11117874, Example 10::US11655221, Example 10::US11680049, Example 10 Dipeptidyl peptidase 1 21.4 US Patent 10.7270/Q2FB56W4 US11673871 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385050&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253835 404854273 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1285094 CC(C)(C)Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C27H32N4O4/c1-27(2,3)17-31-22-14-20(9-10-23(22)35-26(31)33)19-7-5-18(6-8-19)13-21(15-28)30-25(32)24-16-29-11-4-12-34-24/h5-10,14,21,24,29H,4,11-13,16-17H2,1-3H3,(H,30,32)/t21-,24-/m0/s1 WSQINOCTRRFSLG-URXFXBBRSA-N 605446 (2S)-N-[(1S)-1-Cyano-2-{4-[3-(2-hydroxy-2-methylpropyl)-2-oxo-2,3-dihydro-1,3- benzoxazol-5-yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US11673871, Example 11 Dipeptidyl peptidase 1 89.1 US Patent 10.7270/Q2FB56W4 US11673871 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=605446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=605446&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168430488 482598104 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1285095 FC(F)Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H24F2N4O4/c25-22(26)14-30-19-11-17(6-7-20(19)34-24(30)32)16-4-2-15(3-5-16)10-18(12-27)29-23(31)21-13-28-8-1-9-33-21/h2-7,11,18,21-22,28H,1,8-10,13-14H2,(H,29,31)/t18-,21-/m0/s1 ANPJTTUBCRFBKA-RXVVDRJESA-N 50195248 CHEMBL3891374::US10287258, Example 27::US10669245, Example 27::US11117874, Example 27::US11655221, Example 27::US11680049, Example 27 Dipeptidyl peptidase 1 10.0 US Patent 10.7270/Q2FB56W4 US11673871 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195248 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195248&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253888 375977103 CHEMBL3891374 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1285096 CN(C)CCn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C26H31N5O4/c1-30(2)11-12-31-22-15-20(8-9-23(22)35-26(31)33)19-6-4-18(5-7-19)14-21(16-27)29-25(32)24-17-28-10-3-13-34-24/h4-9,15,21,24,28H,3,10-14,17H2,1-2H3,(H,29,32)/t21-,24-/m0/s1 BVHRFMZXVRJZAF-URXFXBBRSA-N 385053 (2S)-N-[(1S)-1-Cyano-2-(4-{3-[2-(dimethylamino)ethyl]-2-oxo-2,3-dihydro-1,3- benzoxazol-5-yl}pheny)ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 13::US10669245, Example 13::US11117874, Example 13::US11655221, Example 13::US11667615, Example 13::US11680049, Example 13 Dipeptidyl peptidase 1 7.24 US Patent 10.7270/Q2FB56W4 US11673871 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385053&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253865 404854276 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1285097 CN1C(=O)C(F)(F)c2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H24F2N4O3/c1-30-20-12-17(7-8-19(20)24(25,26)23(30)32)16-5-3-15(4-6-16)11-18(13-27)29-22(31)21-14-28-9-2-10-33-21/h3-8,12,18,21,28H,2,9-11,14H2,1H3,(H,29,31)/t18-,21-/m0/s1 SABYNPLHFAPZQF-RXVVDRJESA-N 50195242 CHEMBL3917575::US10287258, Example 14::US10669245, Example 14::US11117874, Example 14::US11655221, Example 14::US11680049, Example 14 Dipeptidyl peptidase 1 16.6 US Patent 10.7270/Q2FB56W4 US11673871 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195242&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253811 375977097 CHEMBL3917575 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1285099 CCn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H26N4O4/c1-2-28-20-13-18(8-9-21(20)32-24(28)30)17-6-4-16(5-7-17)12-19(14-25)27-23(29)22-15-26-10-3-11-31-22/h4-9,13,19,22,26H,2-3,10-12,15H2,1H3,(H,27,29)/t19-,22-/m0/s1 HZZYFVOLMKQYKP-UGKGYDQZSA-N 50195246 CHEMBL3980602::US10287258, Example 16::US10669245, Example 16::US11117874, Example 16::US11655221, Example 16 Dipeptidyl peptidase 1 5.75 US Patent 10.7270/Q2FB56W4 US11673871 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195246 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195246&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253883 375977101 CHEMBL3980602 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1285100 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2oc(=O)n(CC3CC3)c2c1)C#N)[C@@H]1CNCCCO1 InChI=1S/C26H28N4O4/c27-14-21(29-25(31)24-15-28-10-1-11-33-24)12-17-4-6-19(7-5-17)20-8-9-23-22(13-20)30(26(32)34-23)16-18-2-3-18/h4-9,13,18,21,24,28H,1-3,10-12,15-16H2,(H,29,31)/t21-,24-/m0/s1 WJXGZWWSCFPECN-URXFXBBRSA-N 385057 (2S)-N-[(1S)-1-Cyano-2-{4-[3-(cyclopropylmethyl)-2-oxo-2,3-dihydro-1,3-benzoxazol- 5-yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 17::US10669245, Example 17::US11117874, Example 17::US11655221, Example 17::US11667615, Example 17::US11680049, Example 17 Dipeptidyl peptidase 1 6.31 US Patent 10.7270/Q2FB56W4 US11673871 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385057&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253827 404854280 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1285101 COCCn1c2cc(ccc2sc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C25H28N4O4S/c1-32-12-10-29-21-14-19(7-8-23(21)34-25(29)31)18-5-3-17(4-6-18)13-20(15-26)28-24(30)22-16-27-9-2-11-33-22/h3-8,14,20,22,27H,2,9-13,16H2,1H3,(H,28,30)/t20-,22-/m0/s1 GRJJVLYWMJAVMA-UNMCSNQZSA-N 385058 (2S)-N-[(1S)-1-Cyano-2-{4-[3-(2-methoxyethyl)-2-oxo-2,3-dihydro-1,3-benzothiazol- 5-yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 18::US10669245, Example 18::US11117874, Example 18::US11655221, Example 18::US11667615, Example 18::US11680049, Example 18 Dipeptidyl peptidase 1 3.16 US Patent 10.7270/Q2FB56W4 US11673871 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385058&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253842 404854281 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1285102 CC(C)n1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C25H28N4O4/c1-16(2)29-21-13-19(8-9-22(21)33-25(29)31)18-6-4-17(5-7-18)12-20(14-26)28-24(30)23-15-27-10-3-11-32-23/h4-9,13,16,20,23,27H,3,10-12,15H2,1-2H3,(H,28,30)/t20-,23-/m0/s1 WOBKXJRTDASPHQ-REWPJTCUSA-N 385059 (2S)-N- [(1S)-1-Cyano-2-{4-[2-oxo-3-(propan-2-yl)-2,3-dihydro-1,3-benzoxazol-5- yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 19::US10669245, Example 19::US11117874, Example 19::US11655221, Example 19::US11667615, Example 19::US11680049, Example 19 Dipeptidyl peptidase 1 14.5 US Patent 10.7270/Q2FB56W4 US11673871 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385059&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253878 404854282 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1285103 CN1C(=O)COc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H26N4O4/c1-28-20-12-18(7-8-21(20)32-15-23(28)29)17-5-3-16(4-6-17)11-19(13-25)27-24(30)22-14-26-9-2-10-31-22/h3-8,12,19,22,26H,2,9-11,14-15H2,1H3,(H,27,30)/t19-,22-/m0/s1 QKDQSHLZLZUQOA-UGKGYDQZSA-N 50195238 CHEMBL3962926::US10287258, Example 20::US10669245, Example 20::US11117874, Example 20::US11655221, Example 20::US11680049, Example 20 Dipeptidyl peptidase 1 12.6 US Patent 10.7270/Q2FB56W4 US11673871 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195238 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195238&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253870 375977093 CHEMBL3962926 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1285104 COCCn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C25H28N4O5/c1-32-12-10-29-21-14-19(7-8-22(21)34-25(29)31)18-5-3-17(4-6-18)13-20(15-26)28-24(30)23-16-27-9-2-11-33-23/h3-8,14,20,23,27H,2,9-13,16H2,1H3,(H,28,30)/t20-,23-/m0/s1 JUXOTDAODWSCQS-REWPJTCUSA-N 385061 (2S)-N-[(1S)-1-Cyano-2-{4-[3-(2-methoxyethyl)-2-oxo-2,3-dihydro-1,3-benzoxazol-5- yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 21::US10669245, Example 21::US11117874, Example 21::US11655221, Example 21::US11667615, Example 21::US11680049, Example 21 Dipeptidyl peptidase 1 8.13 US Patent 10.7270/Q2FB56W4 US11673871 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385061&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253879 404854284 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1285105 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(s1)C#N)C#N)[C@@H]1CNCCCO1 InChI=1S/C20H20N4O2S/c21-11-16(24-20(25)18-13-23-8-1-9-26-18)10-14-2-4-15(5-3-14)19-7-6-17(12-22)27-19/h2-7,16,18,23H,1,8-10,13H2,(H,24,25)/t16-,18-/m0/s1 AYKAKRZDQIFHMD-WMZOPIPTSA-N 385062 (2S)-N-{(1S)-1-Cyano-2-[4-(5-cyanothiophen-2-yl)phenyl]ethyl}-1,4-oxazepane-2- carboxamide::US10287258, Example 22::US10669245, Example 22::US11117874, Example 22::US11655221, Example 22::US11667615, Example 22::US11680049, Example 22 Dipeptidyl peptidase 1 19.5 US Patent 10.7270/Q2FB56W4 US11673871 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385062&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253837 404854285 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1285106 NC(=O)c1ccc(cc1F)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C22H23FN4O3/c23-19-11-16(6-7-18(19)21(25)28)15-4-2-14(3-5-15)10-17(12-24)27-22(29)20-13-26-8-1-9-30-20/h2-7,11,17,20,26H,1,8-10,13H2,(H2,25,28)(H,27,29)/t17-,20-/m0/s1 GCGGEFOSHQPZEX-PXNSSMCTSA-N 385063 (2S)-N-[(1S)-2-(4'-Carbamoy1-3'-fluorobiphenyl-4-yl)-1-cyanoethyl]-1,4-oxazepane-2- carboxamide::US10287258, Example 23::US10669245, Example 23::US11117874, Example 23::US11655221, Example 23::US11667615, Example 23::US11680049, Example 23 Dipeptidyl peptidase 1 67.6 US Patent 10.7270/Q2FB56W4 US11673871 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385063&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253894 404854286 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1285107 Cn1c2cc(ccc2ccc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C25H26N4O3/c1-29-22-14-20(8-7-19(22)9-10-24(29)30)18-5-3-17(4-6-18)13-21(15-26)28-25(31)23-16-27-11-2-12-32-23/h3-10,14,21,23,27H,2,11-13,16H2,1H3,(H,28,31)/t21-,23-/m0/s1 BQIZWZAQEICNDG-GMAHTHKFSA-N 50195244 CHEMBL3926554::US10287258, Example 24::US10669245, Example 24::US11117874, Example 24::US11655221, Example 24::US11680049, Example 24 Dipeptidyl peptidase 1 13.8 US Patent 10.7270/Q2FB56W4 US11673871 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195244&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253851 375977099 CHEMBL3926554 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1285108 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2oc(=O)n(CC3CCOCC3)c2c1)C#N)[C@@H]1CNCCCO1 InChI=1S/C28H32N4O5/c29-16-23(31-27(33)26-17-30-10-1-11-36-26)14-19-2-4-21(5-3-19)22-6-7-25-24(15-22)32(28(34)37-25)18-20-8-12-35-13-9-20/h2-7,15,20,23,26,30H,1,8-14,17-18H2,(H,31,33)/t23-,26-/m0/s1 KFOHIWSKADTAQW-OZXSUGGESA-N 385065 (2S)-N-[(1S)-1-Cyano-2-{4-[2-oxo-3-(tetrahydro-2H-pyran-4-ylmethyl)-2,3-dihydro- 1,3-benzoxazol-5-yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 25::US10669245, Example 25::US11117874, Example 25::US11655221, Example 25::US11667615, Example 25::US11680049, Example 25 Dipeptidyl peptidase 1 10.7 US Patent 10.7270/Q2FB56W4 US11673871 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385065&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253876 404854288 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1285109 Cn1c2cc(cc(Cl)c2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H23ClN4O4/c1-28-19-11-16(10-18(24)21(19)32-23(28)30)15-5-3-14(4-6-15)9-17(12-25)27-22(29)20-13-26-7-2-8-31-20/h3-6,10-11,17,20,26H,2,7-9,13H2,1H3,(H,27,29)/t17-,20-/m0/s1 KTGYWWMCWUTXTI-PXNSSMCTSA-N 385066 (2S)-N-{(1S)-2-[4-(7-Chloro-3-methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)phenyl]- 1-cyanoethyl}-1,4-oxazepane-2-carboxamide::US10287258, Example 26::US10669245, Example 26::US11117874, Example 26::US11655221, Example 26::US11667615, Example 26::US11680049, Example 26 Dipeptidyl peptidase 1 13.5 US Patent 10.7270/Q2FB56W4 US11673871 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385066&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253874 404854289 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1285110 FC(F)Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H24F2N4O4/c25-22(26)14-30-19-11-17(6-7-20(19)34-24(30)32)16-4-2-15(3-5-16)10-18(12-27)29-23(31)21-13-28-8-1-9-33-21/h2-7,11,18,21-22,28H,1,8-10,13-14H2,(H,29,31)/t18-,21-/m0/s1 ANPJTTUBCRFBKA-RXVVDRJESA-N 50195248 CHEMBL3891374::US10287258, Example 27::US10669245, Example 27::US11117874, Example 27::US11655221, Example 27::US11680049, Example 27 Dipeptidyl peptidase 1 6.61 US Patent 10.7270/Q2FB56W4 US11673871 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195248 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195248&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253888 375977103 CHEMBL3891374 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1285111 FC(F)(F)Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H23F3N4O4/c25-24(26,27)14-31-19-11-17(6-7-20(19)35-23(31)33)16-4-2-15(3-5-16)10-18(12-28)30-22(32)21-13-29-8-1-9-34-21/h2-7,11,18,21,29H,1,8-10,13-14H2,(H,30,32)/t18-,21-/m0/s1 KAGSLWGZQVTFPB-RXVVDRJESA-N 385068 (2S)-N-[(1S)-1-Cyano-2-{4-[2-oxo-3-(2,2,2-trifluoroethyl)-2,3-dihydro-1,3- benzoxazol-5-yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 28::US10669245, Example 28::US11117874, Example 28::US11655221, Example 28::US11667615, Example 28::US11680049, Example 28 Dipeptidyl peptidase 1 8.13 US Patent 10.7270/Q2FB56W4 US11673871 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385068&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253867 404854291 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1285112 Cn1c2cc(ccc2sc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H24N4O3S/c1-27-19-12-17(7-8-21(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)20-14-25-9-2-10-30-20/h3-8,12,18,20,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,20-/m0/s1 DRQDONWWFWYTII-ICSRJNTNSA-N 50195239 CHEMBL3972563::US10287258, Example 29::US10669245, Example 29::US11117874, Example 29::US11655221, Example 29::US11680049, Example 29 Dipeptidyl peptidase 1 2.40 US Patent 10.7270/Q2FB56W4 US11673871 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195239&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91826235 375977094 CHEMBL3972563 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1285113 CS(=O)(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C22H25N3O4S/c1-30(27,28)20-9-7-18(8-10-20)17-5-3-16(4-6-17)13-19(14-23)25-22(26)21-15-24-11-2-12-29-21/h3-10,19,21,24H,2,11-13,15H2,1H3,(H,25,26)/t19-,21-/m0/s1 UBRDXNDHEGQOTI-FPOVZHCZSA-N 385070 (2S)-N-{(1S)-1-Cyano-2-[4'-(methylsulfonyl)bipheny1-4-yl]ethyl}-1,4-oxazepane-2- carboxamide::US10287258, Example 30::US10669245, Example 30::US11117874, Example 30::US11655221, Example 30::US11667615, Example 30::US11680049, Example 30 Dipeptidyl peptidase 1 37.2 US Patent 10.7270/Q2FB56W4 US11673871 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385070&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253895 404854293 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1285114 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N1CCC1)C#N)[C@@H]1CNCCCO1 InChI=1S/C24H28N4O4S/c25-16-21(27-24(29)23-17-26-11-1-14-32-23)15-18-3-5-19(6-4-18)20-7-9-22(10-8-20)33(30,31)28-12-2-13-28/h3-10,21,23,26H,1-2,11-15,17H2,(H,27,29)/t21-,23-/m0/s1 CBWWXOUBSQCMHB-GMAHTHKFSA-N 385071 (2S)-N-{(1S)-2-[4'-(Azetidin-1-ylsulfonyl)biphenyl-4-yl]-1-cyanoethyl}-1,4-oxazepane- 2-carboxamide::US10287258, Example 31::US10669245, Example 31::US11117874, Example 31::US11655221, Example 31::US11667615, Example 31::US11680049, Example 31 Dipeptidyl peptidase 1 21.4 US Patent 10.7270/Q2FB56W4 US11673871 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385071&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253890 404854294 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1285098 Cn1c2cc(cc(F)c2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H23FN4O4/c1-28-19-11-16(10-18(24)21(19)32-23(28)30)15-5-3-14(4-6-15)9-17(12-25)27-22(29)20-13-26-7-2-8-31-20/h3-6,10-11,17,20,26H,2,7-9,13H2,1H3,(H,27,29)/t17-,20-/m0/s1 IVHOZTBKWBUDMJ-PXNSSMCTSA-N 385055 (2S)-N-{(1S)-1-Cyano-2-[4-(7-fluoro-3-methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-5- yl)phenyl]ethyl}-1,4-oxazepane-2-carboxamide::US10287258, Example 15::US10669245, Example 15::US11117874, Example 15::US11655221, Example 15::US11667615, Example 15::US11680049, Example 15 Dipeptidyl peptidase 1 5.13 US Patent 10.7270/Q2FB56W4 US11673871 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385055&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253861 404854278 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 912554 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)[C@@H]1CNCCCO1 InChI=1S/C22H22N4O2/c23-13-17-4-8-19(9-5-17)18-6-2-16(3-7-18)12-20(14-24)26-22(27)21-15-25-10-1-11-28-21/h2-9,20-21,25H,1,10-12,15H2,(H,26,27)/t20-,21-/m0/s1 FCRODBUNBQJNPU-SFTDATJTSA-N 50195236 CHEMBL3927609::US10287258, Example 1::US10669245, Example 1::US11117874, Example 1::US11673871, Example 34::US11680049, Example 1 Dipeptidyl peptidase 1 35.5 US Patent 10.7270/Q2862KG7 aid1804472 US10669245 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195236&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253857 375977091 CHEMBL3927609 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 912555 Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H24N4O4/c1-27-19-12-17(7-8-20(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)21-14-25-9-2-10-30-21/h3-8,12,18,21,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,21-/m0/s1 AEXFXNFMSAAELR-RXVVDRJESA-N 50195235 CHEMBL3900409::US10287258, Example 2::US10669245, Example 2::US11117874, Example 2::US11655221, Example 2::US11680049, Example 2 Dipeptidyl peptidase 1 4.47 US Patent 10.7270/Q2862KG7 aid1804472 US10669245 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195235&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253852 375977090 CHEMBL3900409 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 912556 Cc1cc(cc2n(C)c(=O)oc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H26N4O4/c1-15-10-18(12-20-22(15)32-24(30)28(20)2)17-6-4-16(5-7-17)11-19(13-25)27-23(29)21-14-26-8-3-9-31-21/h4-7,10,12,19,21,26H,3,8-9,11,14H2,1-2H3,(H,27,29)/t19-,21-/m0/s1 WCWJGAFMGPMBQG-FPOVZHCZSA-N 50195240 CHEMBL3960432::US10287258, Example 3::US10669245, Example 3::US11117874, Example 3::US11655221, Example 3::US11680049, Example 3 Dipeptidyl peptidase 1 10.2 US Patent 10.7270/Q2862KG7 aid1804472 US10669245 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195240&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253824 375977095 CHEMBL3960432 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 912557 CS(=O)(=O)Oc1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C22H25N3O5S/c1-31(27,28)30-20-5-2-4-18(13-20)17-8-6-16(7-9-17)12-19(14-23)25-22(26)21-15-24-10-3-11-29-21/h2,4-9,13,19,21,24H,3,10-12,15H2,1H3,(H,25,26)/t19-,21-/m0/s1 IRYUDRJLDSHZAO-FPOVZHCZSA-N 385044 4′-[(2S)-2-Cyano-2-{[(2S)-1,4-oxazepan-2-ylcarbonyl]amino}ethyl]biphenyl-3-yl methanesulfonate::US10287258, Example 4::US10669245, Example 4::US11117874, Example 4::US11667615, Example 4::US11680049, Example 4 Dipeptidyl peptidase 1 79.4 US Patent 10.7270/Q2862KG7 aid1804472 US10669245 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385044&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253891 404854267 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 912558 Cc1noc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H24N4O3/c1-15-20-12-18(7-8-21(20)30-27-15)17-5-3-16(4-6-17)11-19(13-24)26-23(28)22-14-25-9-2-10-29-22/h3-8,12,19,22,25H,2,9-11,14H2,1H3,(H,26,28)/t19-,22-/m0/s1 QCTYSVBOKIUUFU-UGKGYDQZSA-N 50195245 CHEMBL3972158::US10287258, Example 5::US10669245, Example 5::US11117874, Example 5::US11655221, Example 5::US11680049, Example 5 Dipeptidyl peptidase 1 16.2 US Patent 10.7270/Q2862KG7 aid1804472 US10669245 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195245 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195245&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253855 375977100 CHEMBL3972158 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 912559 FC(F)(F)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C22H22F3N3O2/c23-22(24,25)18-8-6-17(7-9-18)16-4-2-15(3-5-16)12-19(13-26)28-21(29)20-14-27-10-1-11-30-20/h2-9,19-20,27H,1,10-12,14H2,(H,28,29)/t19-,20-/m0/s1 USBDHHJQNTYSNJ-PMACEKPBSA-N 50195255 CHEMBL3945475::US10287258, Example 6::US10669245, Example 6::US11117874, Example 6::US11655221, Example 6::US11680049, Example 6 Dipeptidyl peptidase 1 36.3 US Patent 10.7270/Q2862KG7 aid1804472 US10669245 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195255 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195255&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253859 375977110 CHEMBL3945475 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 912560 Fc1ccc(cc1F)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C21H21F2N3O2/c22-18-7-6-16(11-19(18)23)15-4-2-14(3-5-15)10-17(12-24)26-21(27)20-13-25-8-1-9-28-20/h2-7,11,17,20,25H,1,8-10,13H2,(H,26,27)/t17-,20-/m0/s1 HSWVIXGRFREZJG-PXNSSMCTSA-N 385047 (2S)-N-[(1S)-1-Cyano-2-(3',4'-difluorobiphenyl-4-yl)ethyl]-1,4-oxazepane-2- carboxamide::US10287258, Example 7::US10669245, Example 7::US11117874, Example 7::US11655221, Example 7::US11667615, Example 7::US11680049, Example 7 Dipeptidyl peptidase 1 69.2 US Patent 10.7270/Q2862KG7 aid1804472 US10669245 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385047&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253829 404854270 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 912561 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(nc1)C#N)C#N)[C@@H]1CNCCCO1 InChI=1S/C21H21N5O2/c22-11-18-7-6-17(13-25-18)16-4-2-15(3-5-16)10-19(12-23)26-21(27)20-14-24-8-1-9-28-20/h2-7,13,19-20,24H,1,8-10,14H2,(H,26,27)/t19-,20-/m0/s1 UZXVZQQAOVNOKG-PMACEKPBSA-N 385048 (2S)-N-{(1S)-1-Cyano-2-[4-(6-cyanopyridin-3-yl)phenyl]ethyl}-1,4-oxazepane-2- carboxamide::US10287258, Example 8::US10669245, Example 8::US11117874, Example 8::US11655221, Example 8::US11667615, Example 8::US11680049, Example 8 Dipeptidyl peptidase 1 87.1 US Patent 10.7270/Q2862KG7 aid1804472 US10669245 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385048&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253853 404854271 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 912562 CN1C(=O)CSc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H26N4O3S/c1-28-20-12-18(7-8-22(20)32-15-23(28)29)17-5-3-16(4-6-17)11-19(13-25)27-24(30)21-14-26-9-2-10-31-21/h3-8,12,19,21,26H,2,9-11,14-15H2,1H3,(H,27,30)/t19-,21-/m0/s1 NSLGCWMFHWURGT-FPOVZHCZSA-N 385049 (2S)-N-{(1S)-1-Cyano-2-[4-(4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzothiazin-6- yl)phenyl]ethyl}-1,4-oxazepane-2-carboxamide::US10287258, Example 9::US10669245, Example 9::US11117874, Example 9::US11655221, Example 9::US11667615, Example 9::US11680049, Example 9 Dipeptidyl peptidase 1 12.9 US Patent 10.7270/Q2862KG7 aid1804472 US10669245 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385049&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253849 404854272 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 912563 CCn1c2cc(cc(C)c2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C25H28N4O4/c1-3-29-21-13-19(11-16(2)23(21)33-25(29)31)18-7-5-17(6-8-18)12-20(14-26)28-24(30)22-15-27-9-4-10-32-22/h5-8,11,13,20,22,27H,3-4,9-10,12,15H2,1-2H3,(H,28,30)/t20-,22-/m0/s1 ORHUZDNZRYZSJO-UNMCSNQZSA-N 385050 (2S)-N-{(1S)-1-Cyano-2-[4-(3-ethyl-7-methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-5- yl)phenyl]ethyl}-1,4-oxazepane-2-carboxamide::US10287258, Example 10::US10669245, Example 10::US11117874, Example 10::US11655221, Example 10::US11680049, Example 10 Dipeptidyl peptidase 1 21.4 US Patent 10.7270/Q2862KG7 aid1804472 US10669245 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385050&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253835 404854273 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 912564 CC(C)(O)Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C26H30N4O5/c1-26(2,33)16-30-21-13-19(8-9-22(21)35-25(30)32)18-6-4-17(5-7-18)12-20(14-27)29-24(31)23-15-28-10-3-11-34-23/h4-9,13,20,23,28,33H,3,10-12,15-16H2,1-2H3,(H,29,31)/t20-,23-/m0/s1 LRDOUIXCGZNESR-REWPJTCUSA-N 385051 (2S)-N-[(1S)-1-Cyano-2-{4-[3-(2-hydroxy-2-methylpropyl)-2-oxo-2,3-dihydro-1,3- benzoxazol-5-yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 11::US10669245, Example 11::US11117874, Example 11::US11655221, Example 11::US11667615, Example 11::US11680049, Example 11 Dipeptidyl peptidase 1 89.1 US Patent 10.7270/Q2862KG7 aid1804472 US10669245 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385051&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253819 404854274 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 912565 FC(F)Cn1c2cc(cc(F)c2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H23F3N4O4/c25-18-9-16(10-19-22(18)35-24(33)31(19)13-21(26)27)15-4-2-14(3-5-15)8-17(11-28)30-23(32)20-12-29-6-1-7-34-20/h2-5,9-10,17,20-21,29H,1,6-8,12-13H2,(H,30,32)/t17-,20-/m0/s1 PVRGXPYTNXSTMU-PXNSSMCTSA-N 385052 (2S)-N-[(1S)-1-Cyano-2-{4-[3-(2,2-difluoroethyl)-7-fluoro-2-oxo-2,3-dihydro-1,3- benzoxazol-5-yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 12::US10669245, Example 12::US11117874, Example 12::US11655221, Example 12::US11667615, Example 12::US11680049, Example 12 Dipeptidyl peptidase 1 10.0 US Patent 10.7270/Q2862KG7 aid1804472 US10669245 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385052&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253812 404854275 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 912566 CN(C)CCn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C26H31N5O4/c1-30(2)11-12-31-22-15-20(8-9-23(22)35-26(31)33)19-6-4-18(5-7-19)14-21(16-27)29-25(32)24-17-28-10-3-13-34-24/h4-9,15,21,24,28H,3,10-14,17H2,1-2H3,(H,29,32)/t21-,24-/m0/s1 BVHRFMZXVRJZAF-URXFXBBRSA-N 385053 (2S)-N-[(1S)-1-Cyano-2-(4-{3-[2-(dimethylamino)ethyl]-2-oxo-2,3-dihydro-1,3- benzoxazol-5-yl}pheny)ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 13::US10669245, Example 13::US11117874, Example 13::US11655221, Example 13::US11667615, Example 13::US11680049, Example 13 Dipeptidyl peptidase 1 7.24 US Patent 10.7270/Q2862KG7 aid1804472 US10669245 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385053&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253865 404854276 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 912567 CN1C(=O)C(F)(F)c2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H24F2N4O3/c1-30-20-12-17(7-8-19(20)24(25,26)23(30)32)16-5-3-15(4-6-16)11-18(13-27)29-22(31)21-14-28-9-2-10-33-21/h3-8,12,18,21,28H,2,9-11,14H2,1H3,(H,29,31)/t18-,21-/m0/s1 SABYNPLHFAPZQF-RXVVDRJESA-N 50195242 CHEMBL3917575::US10287258, Example 14::US10669245, Example 14::US11117874, Example 14::US11655221, Example 14::US11680049, Example 14 Dipeptidyl peptidase 1 16.6 US Patent 10.7270/Q2862KG7 aid1804472 US10669245 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195242&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253811 375977097 CHEMBL3917575 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 912568 Cn1c2cc(cc(F)c2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H23FN4O4/c1-28-19-11-16(10-18(24)21(19)32-23(28)30)15-5-3-14(4-6-15)9-17(12-25)27-22(29)20-13-26-7-2-8-31-20/h3-6,10-11,17,20,26H,2,7-9,13H2,1H3,(H,27,29)/t17-,20-/m0/s1 IVHOZTBKWBUDMJ-PXNSSMCTSA-N 385055 (2S)-N-{(1S)-1-Cyano-2-[4-(7-fluoro-3-methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-5- yl)phenyl]ethyl}-1,4-oxazepane-2-carboxamide::US10287258, Example 15::US10669245, Example 15::US11117874, Example 15::US11655221, Example 15::US11667615, Example 15::US11680049, Example 15 Dipeptidyl peptidase 1 5.13 US Patent 10.7270/Q2862KG7 aid1804472 US10669245 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385055&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253861 404854278 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 912569 CCn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H26N4O4/c1-2-28-20-13-18(8-9-21(20)32-24(28)30)17-6-4-16(5-7-17)12-19(14-25)27-23(29)22-15-26-10-3-11-31-22/h4-9,13,19,22,26H,2-3,10-12,15H2,1H3,(H,27,29)/t19-,22-/m0/s1 HZZYFVOLMKQYKP-UGKGYDQZSA-N 50195246 CHEMBL3980602::US10287258, Example 16::US10669245, Example 16::US11117874, Example 16::US11655221, Example 16 Dipeptidyl peptidase 1 5.75 US Patent 10.7270/Q2862KG7 aid1804472 US10669245 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195246 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195246&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253883 375977101 CHEMBL3980602 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 912570 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2oc(=O)n(CC3CC3)c2c1)C#N)[C@@H]1CNCCCO1 InChI=1S/C26H28N4O4/c27-14-21(29-25(31)24-15-28-10-1-11-33-24)12-17-4-6-19(7-5-17)20-8-9-23-22(13-20)30(26(32)34-23)16-18-2-3-18/h4-9,13,18,21,24,28H,1-3,10-12,15-16H2,(H,29,31)/t21-,24-/m0/s1 WJXGZWWSCFPECN-URXFXBBRSA-N 385057 (2S)-N-[(1S)-1-Cyano-2-{4-[3-(cyclopropylmethyl)-2-oxo-2,3-dihydro-1,3-benzoxazol- 5-yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 17::US10669245, Example 17::US11117874, Example 17::US11655221, Example 17::US11667615, Example 17::US11680049, Example 17 Dipeptidyl peptidase 1 6.31 US Patent 10.7270/Q2862KG7 aid1804472 US10669245 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385057&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253827 404854280 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 912571 COCCn1c2cc(ccc2sc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C25H28N4O4S/c1-32-12-10-29-21-14-19(7-8-23(21)34-25(29)31)18-5-3-17(4-6-18)13-20(15-26)28-24(30)22-16-27-9-2-11-33-22/h3-8,14,20,22,27H,2,9-13,16H2,1H3,(H,28,30)/t20-,22-/m0/s1 GRJJVLYWMJAVMA-UNMCSNQZSA-N 385058 (2S)-N-[(1S)-1-Cyano-2-{4-[3-(2-methoxyethyl)-2-oxo-2,3-dihydro-1,3-benzothiazol- 5-yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 18::US10669245, Example 18::US11117874, Example 18::US11655221, Example 18::US11667615, Example 18::US11680049, Example 18 Dipeptidyl peptidase 1 3.16 US Patent 10.7270/Q2862KG7 aid1804472 US10669245 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385058&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253842 404854281 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 912572 CC(C)n1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C25H28N4O4/c1-16(2)29-21-13-19(8-9-22(21)33-25(29)31)18-6-4-17(5-7-18)12-20(14-26)28-24(30)23-15-27-10-3-11-32-23/h4-9,13,16,20,23,27H,3,10-12,15H2,1-2H3,(H,28,30)/t20-,23-/m0/s1 WOBKXJRTDASPHQ-REWPJTCUSA-N 385059 (2S)-N- [(1S)-1-Cyano-2-{4-[2-oxo-3-(propan-2-yl)-2,3-dihydro-1,3-benzoxazol-5- yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 19::US10669245, Example 19::US11117874, Example 19::US11655221, Example 19::US11667615, Example 19::US11680049, Example 19 Dipeptidyl peptidase 1 14.5 US Patent 10.7270/Q2862KG7 aid1804472 US10669245 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385059&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253878 404854282 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 912573 CN1C(=O)COc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H26N4O4/c1-28-20-12-18(7-8-21(20)32-15-23(28)29)17-5-3-16(4-6-17)11-19(13-25)27-24(30)22-14-26-9-2-10-31-22/h3-8,12,19,22,26H,2,9-11,14-15H2,1H3,(H,27,30)/t19-,22-/m0/s1 QKDQSHLZLZUQOA-UGKGYDQZSA-N 50195238 CHEMBL3962926::US10287258, Example 20::US10669245, Example 20::US11117874, Example 20::US11655221, Example 20::US11680049, Example 20 Dipeptidyl peptidase 1 12.6 US Patent 10.7270/Q2862KG7 aid1804472 US10669245 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195238 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195238&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253870 375977093 CHEMBL3962926 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 912574 COCCn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C25H28N4O5/c1-32-12-10-29-21-14-19(7-8-22(21)34-25(29)31)18-5-3-17(4-6-18)13-20(15-26)28-24(30)23-16-27-9-2-11-33-23/h3-8,14,20,23,27H,2,9-13,16H2,1H3,(H,28,30)/t20-,23-/m0/s1 JUXOTDAODWSCQS-REWPJTCUSA-N 385061 (2S)-N-[(1S)-1-Cyano-2-{4-[3-(2-methoxyethyl)-2-oxo-2,3-dihydro-1,3-benzoxazol-5- yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 21::US10669245, Example 21::US11117874, Example 21::US11655221, Example 21::US11667615, Example 21::US11680049, Example 21 Dipeptidyl peptidase 1 8.13 US Patent 10.7270/Q2862KG7 aid1804472 US10669245 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385061&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253879 404854284 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 912575 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(s1)C#N)C#N)[C@@H]1CNCCCO1 InChI=1S/C20H20N4O2S/c21-11-16(24-20(25)18-13-23-8-1-9-26-18)10-14-2-4-15(5-3-14)19-7-6-17(12-22)27-19/h2-7,16,18,23H,1,8-10,13H2,(H,24,25)/t16-,18-/m0/s1 AYKAKRZDQIFHMD-WMZOPIPTSA-N 385062 (2S)-N-{(1S)-1-Cyano-2-[4-(5-cyanothiophen-2-yl)phenyl]ethyl}-1,4-oxazepane-2- carboxamide::US10287258, Example 22::US10669245, Example 22::US11117874, Example 22::US11655221, Example 22::US11667615, Example 22::US11680049, Example 22 Dipeptidyl peptidase 1 19.5 US Patent 10.7270/Q2862KG7 aid1804472 US10669245 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385062&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253837 404854285 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 912576 NC(=O)c1ccc(cc1F)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C22H23FN4O3/c23-19-11-16(6-7-18(19)21(25)28)15-4-2-14(3-5-15)10-17(12-24)27-22(29)20-13-26-8-1-9-30-20/h2-7,11,17,20,26H,1,8-10,13H2,(H2,25,28)(H,27,29)/t17-,20-/m0/s1 GCGGEFOSHQPZEX-PXNSSMCTSA-N 385063 (2S)-N-[(1S)-2-(4'-Carbamoy1-3'-fluorobiphenyl-4-yl)-1-cyanoethyl]-1,4-oxazepane-2- carboxamide::US10287258, Example 23::US10669245, Example 23::US11117874, Example 23::US11655221, Example 23::US11667615, Example 23::US11680049, Example 23 Dipeptidyl peptidase 1 67.6 US Patent 10.7270/Q2862KG7 aid1804472 US10669245 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385063&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253894 404854286 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 912577 Cn1c2cc(ccc2ccc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C25H26N4O3/c1-29-22-14-20(8-7-19(22)9-10-24(29)30)18-5-3-17(4-6-18)13-21(15-26)28-25(31)23-16-27-11-2-12-32-23/h3-10,14,21,23,27H,2,11-13,16H2,1H3,(H,28,31)/t21-,23-/m0/s1 BQIZWZAQEICNDG-GMAHTHKFSA-N 50195244 CHEMBL3926554::US10287258, Example 24::US10669245, Example 24::US11117874, Example 24::US11655221, Example 24::US11680049, Example 24 Dipeptidyl peptidase 1 13.8 US Patent 10.7270/Q2862KG7 aid1804472 US10669245 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195244&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253851 375977099 CHEMBL3926554 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 912578 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2oc(=O)n(CC3CCOCC3)c2c1)C#N)[C@@H]1CNCCCO1 InChI=1S/C28H32N4O5/c29-16-23(31-27(33)26-17-30-10-1-11-36-26)14-19-2-4-21(5-3-19)22-6-7-25-24(15-22)32(28(34)37-25)18-20-8-12-35-13-9-20/h2-7,15,20,23,26,30H,1,8-14,17-18H2,(H,31,33)/t23-,26-/m0/s1 KFOHIWSKADTAQW-OZXSUGGESA-N 385065 (2S)-N-[(1S)-1-Cyano-2-{4-[2-oxo-3-(tetrahydro-2H-pyran-4-ylmethyl)-2,3-dihydro- 1,3-benzoxazol-5-yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 25::US10669245, Example 25::US11117874, Example 25::US11655221, Example 25::US11667615, Example 25::US11680049, Example 25 Dipeptidyl peptidase 1 10.7 US Patent 10.7270/Q2862KG7 aid1804472 US10669245 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385065&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253876 404854288 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 912579 Cn1c2cc(cc(Cl)c2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H23ClN4O4/c1-28-19-11-16(10-18(24)21(19)32-23(28)30)15-5-3-14(4-6-15)9-17(12-25)27-22(29)20-13-26-7-2-8-31-20/h3-6,10-11,17,20,26H,2,7-9,13H2,1H3,(H,27,29)/t17-,20-/m0/s1 KTGYWWMCWUTXTI-PXNSSMCTSA-N 385066 (2S)-N-{(1S)-2-[4-(7-Chloro-3-methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)phenyl]- 1-cyanoethyl}-1,4-oxazepane-2-carboxamide::US10287258, Example 26::US10669245, Example 26::US11117874, Example 26::US11655221, Example 26::US11667615, Example 26::US11680049, Example 26 Dipeptidyl peptidase 1 13.5 US Patent 10.7270/Q2862KG7 aid1804472 US10669245 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385066&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253874 404854289 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 912580 FC(F)Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H24F2N4O4/c25-22(26)14-30-19-11-17(6-7-20(19)34-24(30)32)16-4-2-15(3-5-16)10-18(12-27)29-23(31)21-13-28-8-1-9-33-21/h2-7,11,18,21-22,28H,1,8-10,13-14H2,(H,29,31)/t18-,21-/m0/s1 ANPJTTUBCRFBKA-RXVVDRJESA-N 50195248 CHEMBL3891374::US10287258, Example 27::US10669245, Example 27::US11117874, Example 27::US11655221, Example 27::US11680049, Example 27 Dipeptidyl peptidase 1 6.61 US Patent 10.7270/Q2862KG7 aid1804472 US10669245 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195248 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195248&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253888 375977103 CHEMBL3891374 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 912581 FC(F)(F)Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H23F3N4O4/c25-24(26,27)14-31-19-11-17(6-7-20(19)35-23(31)33)16-4-2-15(3-5-16)10-18(12-28)30-22(32)21-13-29-8-1-9-34-21/h2-7,11,18,21,29H,1,8-10,13-14H2,(H,30,32)/t18-,21-/m0/s1 KAGSLWGZQVTFPB-RXVVDRJESA-N 385068 (2S)-N-[(1S)-1-Cyano-2-{4-[2-oxo-3-(2,2,2-trifluoroethyl)-2,3-dihydro-1,3- benzoxazol-5-yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 28::US10669245, Example 28::US11117874, Example 28::US11655221, Example 28::US11667615, Example 28::US11680049, Example 28 Dipeptidyl peptidase 1 8.13 US Patent 10.7270/Q2862KG7 aid1804472 US10669245 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385068&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253867 404854291 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 912582 Cn1c2cc(ccc2sc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H24N4O3S/c1-27-19-12-17(7-8-21(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)20-14-25-9-2-10-30-20/h3-8,12,18,20,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,20-/m0/s1 DRQDONWWFWYTII-ICSRJNTNSA-N 50195239 CHEMBL3972563::US10287258, Example 29::US10669245, Example 29::US11117874, Example 29::US11655221, Example 29::US11680049, Example 29 Dipeptidyl peptidase 1 2.40 US Patent 10.7270/Q2862KG7 aid1804472 US10669245 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195239&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91826235 375977094 CHEMBL3972563 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 912583 CS(=O)(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C22H25N3O4S/c1-30(27,28)20-9-7-18(8-10-20)17-5-3-16(4-6-17)13-19(14-23)25-22(26)21-15-24-11-2-12-29-21/h3-10,19,21,24H,2,11-13,15H2,1H3,(H,25,26)/t19-,21-/m0/s1 UBRDXNDHEGQOTI-FPOVZHCZSA-N 385070 (2S)-N-{(1S)-1-Cyano-2-[4'-(methylsulfonyl)bipheny1-4-yl]ethyl}-1,4-oxazepane-2- carboxamide::US10287258, Example 30::US10669245, Example 30::US11117874, Example 30::US11655221, Example 30::US11667615, Example 30::US11680049, Example 30 Dipeptidyl peptidase 1 37.2 US Patent 10.7270/Q2862KG7 aid1804472 US10669245 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385070&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253895 404854293 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 912584 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N1CCC1)C#N)[C@@H]1CNCCCO1 InChI=1S/C24H28N4O4S/c25-16-21(27-24(29)23-17-26-11-1-14-32-23)15-18-3-5-19(6-4-18)20-7-9-22(10-8-20)33(30,31)28-12-2-13-28/h3-10,21,23,26H,1-2,11-15,17H2,(H,27,29)/t21-,23-/m0/s1 CBWWXOUBSQCMHB-GMAHTHKFSA-N 385071 (2S)-N-{(1S)-2-[4'-(Azetidin-1-ylsulfonyl)biphenyl-4-yl]-1-cyanoethyl}-1,4-oxazepane- 2-carboxamide::US10287258, Example 31::US10669245, Example 31::US11117874, Example 31::US11655221, Example 31::US11667615, Example 31::US11680049, Example 31 Dipeptidyl peptidase 1 21.4 US Patent 10.7270/Q2862KG7 aid1804472 US10669245 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385071&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253890 404854294 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 912585 Fc1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C21H22FN3O2/c22-18-8-6-17(7-9-18)16-4-2-15(3-5-16)12-19(13-23)25-21(26)20-14-24-10-1-11-27-20/h2-9,19-20,24H,1,10-12,14H2,(H,25,26)/t19-,20-/m0/s1 PYXGGJVWIVBQRO-PMACEKPBSA-N 385072 (2S)-N-[(1S)-1-Cyano-2-(4'-fluorobiphenyl-4-yl)ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 32::US10669245, Example 32::US11117874, Example 32::US11655221, Example 32::US11667615, Example 32::US11680049, Example 32 Dipeptidyl peptidase 1 42.7 US Patent 10.7270/Q2862KG7 aid1804472 US10669245 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385072&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253858 404854295 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 912586 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2scnc2c1)C#N)[C@@H]1CNCCCO1 InChI=1S/C22H22N4O2S/c23-12-18(26-22(27)20-13-24-8-1-9-28-20)10-15-2-4-16(5-3-15)17-6-7-21-19(11-17)25-14-29-21/h2-7,11,14,18,20,24H,1,8-10,13H2,(H,26,27)/t18-,20-/m0/s1 MUTKXUKCDAFWLB-ICSRJNTNSA-N 50195263 CHEMBL3942969::US10287258, Example 33::US10669245, Example 33::US11117874, Example 33::US11673871, Example 33::US11680049, Example 33 Dipeptidyl peptidase 1 61.7 US Patent 10.7270/Q2862KG7 aid1804472 US10669245 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195263&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253877 375977118 CHEMBL3942969 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 912587 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)C1CNCCCO1 InChI=1S/C22H22N4O2/c23-13-17-4-8-19(9-5-17)18-6-2-16(3-7-18)12-20(14-24)26-22(27)21-15-25-10-1-11-28-21/h2-9,20-21,25H,1,10-12,15H2,(H,26,27)/t20-,21?/m0/s1 FCRODBUNBQJNPU-BGERDNNASA-N 385074 US10287258, Example 34::US10669245, Example 34::US11117874, Example 34::US11667615, Example 34::US11680049, Example 34 Dipeptidyl peptidase 1 60.3 US Patent 10.7270/Q2862KG7 aid1804472 US10669245 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385074&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118260121 404854297 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 912588 CN1C(=O)CNc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H27N5O3/c1-29-21-12-18(7-8-20(21)27-15-23(29)30)17-5-3-16(4-6-17)11-19(13-25)28-24(31)22-14-26-9-2-10-32-22/h3-8,12,19,22,26-27H,2,9-11,14-15H2,1H3,(H,28,31)/t19-,22-/m0/s1 CPBDCTBYFQTDMV-UGKGYDQZSA-N 385075 US10287258, Example 35::US10669245, Example 35::US11117874, Example 35::US11673871, Example 35::US11680049, Example 35 Dipeptidyl peptidase 1 24.5 US Patent 10.7270/Q2862KG7 aid1804472 US10669245 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385075&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253822 404854298 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 912589 CC[C@H](NC(=O)[C@@H]1CNCCCO1)\C=C\C(=O)N1CCc2ccccc12 InChI=1S/C20H27N3O3/c1-2-16(22-20(25)18-14-21-11-5-13-26-18)8-9-19(24)23-12-10-15-6-3-4-7-17(15)23/h3-4,6-9,16,18,21H,2,5,10-14H2,1H3,(H,22,25)/b9-8+/t16-,18-/m0/s1 OHNHQTNQBQMALV-LFGVRAQPSA-N 385076 BDBM445984::US10287258, Example 36::US11667615, Example 36::US11680049, Example 36 Dipeptidyl peptidase 1 5.01 US Patent 10.7270/Q2862KG7 aid1804472 US10669245 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385076&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 144891673 404854299 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 912590 CC(C)C[C@H](NC(=O)[C@@H]1CNCCCO1)\C=C\C(=O)N1CCc2ccccc12 InChI=1S/C22H31N3O3/c1-16(2)14-18(24-22(27)20-15-23-11-5-13-28-20)8-9-21(26)25-12-10-17-6-3-4-7-19(17)25/h3-4,6-9,16,18,20,23H,5,10-15H2,1-2H3,(H,24,27)/b9-8+/t18-,20+/m1/s1 PXFMGAFAIVURSO-ZZHWGSSASA-N 385077 BDBM445985::US10287258, Example 37::US11667615, Example 37::US11680049, Example 37 Dipeptidyl peptidase 1 5.25 US Patent 10.7270/Q2862KG7 aid1804472 US10669245 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385077&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 144891689 404854300 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51223181 O[C@H]1CN[C@@H](C1)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N InChI=1S/C21H20N4O2/c22-11-15-3-7-17(8-4-15)16-5-1-14(2-6-16)9-18(12-23)25-21(27)20-10-19(26)13-24-20/h1-8,18-20,24,26H,9-10,13H2,(H,25,27)/t18-,19+,20-/m0/s1 KWPRPAMWUBNTIJ-ZCNNSNEGSA-N 50502616 CHEMBL4564319 Dipeptidyl peptidase 1 50 ChEMBL 10.1021/acsmedchemlett.9b00261 10.7270/Q2WM1HPF 31413809 Käck, H; Doyle, K; Hughes, SJ; Bodnarchuk, MS; Lönn, H; Van De Poël, A; Palmer, N AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50502616 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50502616&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 155559747 440711201 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51223182 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)[C@@H]1CCCN1 InChI=1S/C21H20N4O/c22-13-16-5-9-18(10-6-16)17-7-3-15(4-8-17)12-19(14-23)25-21(26)20-2-1-11-24-20/h3-10,19-20,24H,1-2,11-12H2,(H,25,26)/t19-,20-/m0/s1 DCGIOYVBHXSQMR-PMACEKPBSA-N 50502617 CHEMBL4570759 Dipeptidyl peptidase 1 50 ChEMBL 10.1021/acsmedchemlett.9b00261 10.7270/Q2WM1HPF 31413809 Käck, H; Doyle, K; Hughes, SJ; Bodnarchuk, MS; Lönn, H; Van De Poël, A; Palmer, N AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50502617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50502617&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 155561515 440711202 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51223183 F[C@H]1CN[C@@H](C1)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N InChI=1S/C21H19FN4O/c22-18-10-20(25-13-18)21(27)26-19(12-24)9-14-1-5-16(6-2-14)17-7-3-15(11-23)4-8-17/h1-8,18-20,25H,9-10,13H2,(H,26,27)/t18-,19+,20+/m1/s1 KFJLAGJTTKZVPA-AABGKKOBSA-N 50502618 CHEMBL4461966 Dipeptidyl peptidase 1 631 ChEMBL 10.1021/acsmedchemlett.9b00261 10.7270/Q2WM1HPF 31413809 Käck, H; Doyle, K; Hughes, SJ; Bodnarchuk, MS; Lönn, H; Van De Poël, A; Palmer, N AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50502618 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50502618&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 155528739 440711203 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51223184 CS[C@@H]1CN[C@@H](C1)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N InChI=1S/C22H22N4OS/c1-28-20-11-21(25-14-20)22(27)26-19(13-24)10-15-2-6-17(7-3-15)18-8-4-16(12-23)5-9-18/h2-9,19-21,25H,10-11,14H2,1H3,(H,26,27)/t19-,20-,21-/m0/s1 QZOKEGHUJKJWFT-ACRUOGEOSA-N 50502619 CHEMBL4561264 Dipeptidyl peptidase 1 0.398107 ChEMBL 10.1021/acsmedchemlett.9b00261 10.7270/Q2WM1HPF 31413809 Käck, H; Doyle, K; Hughes, SJ; Bodnarchuk, MS; Lönn, H; Van De Poël, A; Palmer, N AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50502619 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50502619&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 155543410 440711204 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51223185 FC1(F)CN[C@@H](C1)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N InChI=1S/C21H18F2N4O/c22-21(23)10-19(26-13-21)20(28)27-18(12-25)9-14-1-5-16(6-2-14)17-7-3-15(11-24)4-8-17/h1-8,18-19,26H,9-10,13H2,(H,27,28)/t18-,19-/m0/s1 BOKLUKKTSGRCJO-OALUTQOASA-N 50502620 CHEMBL4451898 Dipeptidyl peptidase 1 79 ChEMBL 10.1021/acsmedchemlett.9b00261 10.7270/Q2WM1HPF 31413809 Käck, H; Doyle, K; Hughes, SJ; Bodnarchuk, MS; Lönn, H; Van De Poël, A; Palmer, N AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50502620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50502620&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 155522247 440711205 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51223186 O[C@@H]1CN[C@@H](C1)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N InChI=1S/C21H20N4O2/c22-11-15-3-7-17(8-4-15)16-5-1-14(2-6-16)9-18(12-23)25-21(27)20-10-19(26)13-24-20/h1-8,18-20,24,26H,9-10,13H2,(H,25,27)/t18-,19-,20-/m0/s1 KWPRPAMWUBNTIJ-UFYCRDLUSA-N 50502621 CHEMBL4513306 Dipeptidyl peptidase 1 6.3 ChEMBL 10.1021/acsmedchemlett.9b00261 10.7270/Q2WM1HPF 31413809 Käck, H; Doyle, K; Hughes, SJ; Bodnarchuk, MS; Lönn, H; Van De Poël, A; Palmer, N AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50502621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50502621&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 155538869 440711206 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51223187 F[C@@H]1CN[C@@H](C1)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N InChI=1S/C21H19FN4O/c22-18-10-20(25-13-18)21(27)26-19(12-24)9-14-1-5-16(6-2-14)17-7-3-15(11-23)4-8-17/h1-8,18-20,25H,9-10,13H2,(H,26,27)/t18-,19-,20-/m0/s1 KFJLAGJTTKZVPA-UFYCRDLUSA-N 50502622 CHEMBL4579467 Dipeptidyl peptidase 1 1.6 ChEMBL 10.1021/acsmedchemlett.9b00261 10.7270/Q2WM1HPF 31413809 Käck, H; Doyle, K; Hughes, SJ; Bodnarchuk, MS; Lönn, H; Van De Poël, A; Palmer, N AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50502622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50502622&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 155565392 440711207 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51223188 O[C@H]1CN[C@@H](C1)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccccc1)C#N InChI=1S/C20H21N3O2/c21-12-17(23-20(25)19-11-18(24)13-22-19)10-14-6-8-16(9-7-14)15-4-2-1-3-5-15/h1-9,17-19,22,24H,10-11,13H2,(H,23,25)/t17-,18+,19-/m0/s1 MGFTXCGHJLDIQL-OTWHNJEPSA-N 50502623 CHEMBL4538307 Dipeptidyl peptidase 1 158 ChEMBL 10.1021/acsmedchemlett.9b00261 10.7270/Q2WM1HPF 31413809 Käck, H; Doyle, K; Hughes, SJ; Bodnarchuk, MS; Lönn, H; Van De Poël, A; Palmer, N AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50502623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50502623&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 42641779 440711208 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288591 Fc1ccc(Nc2ncnc3cc(OCCCN4CCOCC4)c(NC(=O)C=C)cc23)cc1Cl InChI=1S/C24H25ClFN5O3/c1-2-23(32)30-21-13-17-20(14-22(21)34-9-3-6-31-7-10-33-11-8-31)27-15-28-24(17)29-16-4-5-19(26)18(25)12-16/h2,4-5,12-15H,1,3,6-11H2,(H,30,32)(H,27,28,29) OMZCMEYTWSXEPZ-UHFFFAOYSA-N 4779 CHEMBL31965::CHEMBL545315::CI-1033::Canertinib::N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(morpholin-4-yl)propoxy]quinazolin-6-yl}prop-2-enamide::PD0183805::US10507209, Compound CI-1033::US9730934, CI-1033::cid_156414 Dipeptidyl peptidase 1 2700 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4779&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156414 8034429 61399 CHEMBL31965CHEMBL545315 DB05424 5675 ZINC27439698 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288592 COc1cc(ccc1Nc1ccc(N2CCCCC2)c(Oc2ccc(c(NC(=O)C=C)c2)C(F)(F)F)n1)N1CCN(C)CC1 InChI=1S/C32H37F3N6O3/c1-4-30(42)37-26-21-23(9-10-24(26)32(33,34)35)44-31-27(41-14-6-5-7-15-41)12-13-29(38-31)36-25-11-8-22(20-28(25)43-3)40-18-16-39(2)17-19-40/h4,8-13,20-21H,1,5-7,14-19H2,2-3H3,(H,36,38)(H,37,42) SUGZGJPNARHPMK-UHFFFAOYSA-N 50525273 CHEMBL4465060 Dipeptidyl peptidase 1 1.8 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525273 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525273&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 152823047 440733855 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288595 CN(C)C1CCN(CC1)c1ccc(Nc2ccc(N3CCCCC3)c(Oc3ccc(C)c(NC(=O)C=C)c3)n2)nc1 InChI=1S/C32H41N7O2/c1-5-31(40)34-27-21-26(11-9-23(27)2)41-32-28(39-17-7-6-8-18-39)12-14-30(36-32)35-29-13-10-25(22-33-29)38-19-15-24(16-20-38)37(3)4/h5,9-14,21-22,24H,1,6-8,15-20H2,2-4H3,(H,34,40)(H,33,35,36) BUXDVRKYYXZOPJ-UHFFFAOYSA-N 50525276 CHEMBL4466182 Dipeptidyl peptidase 1 307 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525276 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525276&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 149839762 440733858 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288596 COc1cc(ccc1Nc1ccc(N2CCCC2)c(Oc2ccc(C)c(NC(=O)C=C)c2)n1)N1CCN(C)CC1 InChI=1S/C31H38N6O3/c1-5-30(38)33-26-21-24(10-8-22(26)2)40-31-27(37-14-6-7-15-37)12-13-29(34-31)32-25-11-9-23(20-28(25)39-4)36-18-16-35(3)17-19-36/h5,8-13,20-21H,1,6-7,14-19H2,2-4H3,(H,32,34)(H,33,38) JAHBFOVLZZJYDG-UHFFFAOYSA-N 50525274 CHEMBL4465111 Dipeptidyl peptidase 1 41 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525274 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525274&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 148018738 440733856 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288597 COc1cc(ccc1Nc1ccc(N2CCCCC2)c(Oc2ccc(C)c(NC(=O)C=C)c2)n1)N1CCC(CC1)N(C)C InChI=1S/C34H44N6O3/c1-6-33(41)36-29-23-27(12-10-24(29)2)43-34-30(40-18-8-7-9-19-40)14-15-32(37-34)35-28-13-11-26(22-31(28)42-5)39-20-16-25(17-21-39)38(3)4/h6,10-15,22-23,25H,1,7-9,16-21H2,2-5H3,(H,35,37)(H,36,41) UAVSAGIAKWMDMK-UHFFFAOYSA-N 50525277 CHEMBL4525977 Dipeptidyl peptidase 1 2.2 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525277 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525277&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 151971947 440733859 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288598 COc1cc(ccc1Nc1ccc(c(Oc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCN(C)CC1 InChI=1S/C27H28F3N5O3/c1-4-25(36)31-18-6-5-7-20(16-18)38-26-21(27(28,29)30)9-11-24(33-26)32-22-10-8-19(17-23(22)37-3)35-14-12-34(2)13-15-35/h4-11,16-17H,1,12-15H2,2-3H3,(H,31,36)(H,32,33) NZLARQLGUAXRDT-UHFFFAOYSA-N 50525278 CHEMBL4514494 Dipeptidyl peptidase 1 1605 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525278 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525278&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 151286177 440733860 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288599 COc1ccc(Oc2nc(Nc3ccc(cc3OC)N3CCN(C)CC3)ccc2N2CCCC2)cc1NC(=O)C=C InChI=1S/C31H38N6O4/c1-5-30(38)33-25-21-23(9-12-27(25)39-3)41-31-26(37-14-6-7-15-37)11-13-29(34-31)32-24-10-8-22(20-28(24)40-4)36-18-16-35(2)17-19-36/h5,8-13,20-21H,1,6-7,14-19H2,2-4H3,(H,32,34)(H,33,38) WDPRWBSLRSAWMZ-UHFFFAOYSA-N 50525279 CHEMBL4560030 Dipeptidyl peptidase 1 140 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525279&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 152242423 440733861 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288600 COc1cc(ccc1Nc1ccc(N2CCCC(O)C2)c(Oc2ccc(C)c(NC(=O)C=C)c2)n1)N1CCN(C)CC1 InChI=1S/C32H40N6O4/c1-5-31(40)34-27-20-25(10-8-22(27)2)42-32-28(38-14-6-7-24(39)21-38)12-13-30(35-32)33-26-11-9-23(19-29(26)41-4)37-17-15-36(3)16-18-37/h5,8-13,19-20,24,39H,1,6-7,14-18,21H2,2-4H3,(H,33,35)(H,34,40) NVVMUQZCIADBFK-UHFFFAOYSA-N 50525280 CHEMBL4578535 Dipeptidyl peptidase 1 4.9 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525280 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525280&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 151268438 440733862 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288601 COc1cc(ccc1Nc1ccc(N2CCC(O)C2)c(Oc2ccc(C)c(NC(=O)C=C)c2)n1)N1CCN(C)CC1 InChI=1S/C31H38N6O4/c1-5-30(39)33-26-19-24(8-6-21(26)2)41-31-27(37-13-12-23(38)20-37)10-11-29(34-31)32-25-9-7-22(18-28(25)40-4)36-16-14-35(3)15-17-36/h5-11,18-19,23,38H,1,12-17,20H2,2-4H3,(H,32,34)(H,33,39) PONPXMDPXUKJAO-UHFFFAOYSA-N 50525281 CHEMBL4456214 Dipeptidyl peptidase 1 28 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525281&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 146685679 440733863 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288602 COc1cc(ccc1Nc1ccc(N2CCOCC2)c(Oc2ccc(C)c(NC(=O)C=C)c2)n1)N1CCN(C)CC1 InChI=1S/C31H38N6O4/c1-5-30(38)33-26-21-24(8-6-22(26)2)41-31-27(37-16-18-40-19-17-37)10-11-29(34-31)32-25-9-7-23(20-28(25)39-4)36-14-12-35(3)13-15-36/h5-11,20-21H,1,12-19H2,2-4H3,(H,32,34)(H,33,38) ZFFQUKVWTLUZRB-UHFFFAOYSA-N 50525282 CHEMBL4464752 Dipeptidyl peptidase 1 3.9 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525282 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525282&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 149491764 440733864 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288603 CN1CCN(CC1)c1ccc(Nc2ccc(N3CCCCC3)c(Oc3ccc(C)c(NC(=O)C=C)c3)n2)cc1 InChI=1S/C31H38N6O2/c1-4-30(38)33-27-22-26(13-8-23(27)2)39-31-28(37-16-6-5-7-17-37)14-15-29(34-31)32-24-9-11-25(12-10-24)36-20-18-35(3)19-21-36/h4,8-15,22H,1,5-7,16-21H2,2-3H3,(H,32,34)(H,33,38) LTZMKTRBHXYEOB-UHFFFAOYSA-N 50525283 CHEMBL4458557 Dipeptidyl peptidase 1 2.7 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525283&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 148412521 440733865 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288604 COc1nc(ccc1Nc1ccc(N2CCCCC2)c(Oc2ccc(C)c(NC(=O)C=C)c2)n1)N1CCN(C)CC1 InChI=1S/C31H39N7O3/c1-5-29(39)33-25-21-23(10-9-22(25)2)41-31-26(37-15-7-6-8-16-37)12-13-27(34-31)32-24-11-14-28(35-30(24)40-4)38-19-17-36(3)18-20-38/h5,9-14,21H,1,6-8,15-20H2,2-4H3,(H,32,34)(H,33,39) PTEDRHAOUDENOU-UHFFFAOYSA-N 50525284 CHEMBL4463389 Dipeptidyl peptidase 1 6.5 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525284&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 148967294 440733866 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288605 COc1cc(ccc1Nc1ccc(N2CCCCC2)c(Oc2ccc(C)c(NC(=O)C=C)c2)n1)N1CCC(CC1)N(C)C InChI=1S/C34H44N6O3/c1-6-33(41)36-29-23-27(12-10-24(29)2)43-34-30(40-18-8-7-9-19-40)14-15-32(37-34)35-28-13-11-26(22-31(28)42-5)39-20-16-25(17-21-39)38(3)4/h6,10-15,22-23,25H,1,7-9,16-21H2,2-5H3,(H,35,37)(H,36,41) UAVSAGIAKWMDMK-UHFFFAOYSA-N 50525277 CHEMBL4525977 Dipeptidyl peptidase 1 1.000000 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525277 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525277&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 151971947 440733859 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288617 COc1nn(C)cc1Nc1nc(nc2n(C)cnc12)C1C[C@@H](F)[C@@H](C1)NC(=O)C=C InChI=1S/C19H23FN8O2/c1-5-14(29)22-12-7-10(6-11(12)20)16-24-17(15-18(25-16)27(2)9-21-15)23-13-8-28(3)26-19(13)30-4/h5,8-12H,1,6-7H2,2-4H3,(H,22,29)(H,23,24,25)/t10?,11-,12-/m1/s1 YQTDEGYGQASMEP-PQDIPPBSSA-N 50525285 CHEMBL4451100 Dipeptidyl peptidase 1 >10000 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525285&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 155521718 440733867 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288618 CN(C)C\C=C\C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1 InChI=1S/C24H25ClFN5O3/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29)/b4-3+/t16-/m0/s1 ULXXDDBFHOBEHA-CWDCEQMOSA-N 50322823 (S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide::AFATINIB::CHEMBL1173655::US10085983, Compound BIBW2992::US10196365, Afatinib::US10435400, Compound BIBW2992::US9388170, Afatinib::US9890168, Compound BIBW2992::WO2022090481, Example afatinib Dipeptidyl peptidase 1 >10000 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50322823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50322823&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 0WM 4G5J 10184653 104144352 61390 CHEMBL1173655 DB08916 5667 ZINC03976838 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288619 CN1CCN(CC1)c1ccc(Nc2ccc(Cl)c(Oc3cccc(NC(=O)C=C)c3)n2)cc1 InChI=1S/C25H26ClN5O2/c1-3-24(32)28-19-5-4-6-21(17-19)33-25-22(26)11-12-23(29-25)27-18-7-9-20(10-8-18)31-15-13-30(2)14-16-31/h3-12,17H,1,13-16H2,2H3,(H,27,29)(H,28,32) XMUNQTPMDZGWFQ-UHFFFAOYSA-N 50525286 CHEMBL4447167 Dipeptidyl peptidase 1 483 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525286&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 155518852 440733868 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288620 Clc1ccc(Nc2ccc(cc2)N2CCNCC2)nc1Oc1cccc(NC(=O)C=C)c1 InChI=1S/C24H24ClN5O2/c1-2-23(31)28-18-4-3-5-20(16-18)32-24-21(25)10-11-22(29-24)27-17-6-8-19(9-7-17)30-14-12-26-13-15-30/h2-11,16,26H,1,12-15H2,(H,27,29)(H,28,31) MRTOVCAXMUXNBO-UHFFFAOYSA-N 50525287 CHEMBL4469443 Dipeptidyl peptidase 1 499 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525287&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 151118910 440733869 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288621 Clc1ccc(Nc2ccc(cc2)N2CCOCC2)nc1Oc1cccc(NC(=O)C=C)c1 InChI=1S/C24H23ClN4O3/c1-2-23(30)27-18-4-3-5-20(16-18)32-24-21(25)10-11-22(28-24)26-17-6-8-19(9-7-17)29-12-14-31-15-13-29/h2-11,16H,1,12-15H2,(H,26,28)(H,27,30) KGPIUEMTCZJTDW-UHFFFAOYSA-N 50525288 CHEMBL4452125 Dipeptidyl peptidase 1 >10000 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525288 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525288&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 148192765 440733870 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288622 NCCc1ccc(Nc2ccc(Cl)c(Oc3cccc(NC(=O)C=C)c3)n2)cc1 InChI=1S/C22H21ClN4O2/c1-2-21(28)26-17-4-3-5-18(14-17)29-22-19(23)10-11-20(27-22)25-16-8-6-15(7-9-16)12-13-24/h2-11,14H,1,12-13,24H2,(H,25,27)(H,26,28) OPPORAPDJMQHCS-UHFFFAOYSA-N 50525289 CHEMBL4567326 Dipeptidyl peptidase 1 2051 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525289&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 148809433 440733871 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288623 Clc1ccc(Nc2ccc(cc2)N2CCN(CC3CC3)CC2)nc1Oc1cccc(NC(=O)C=C)c1 InChI=1S/C28H30ClN5O2/c1-2-27(35)31-22-4-3-5-24(18-22)36-28-25(29)12-13-26(32-28)30-21-8-10-23(11-9-21)34-16-14-33(15-17-34)19-20-6-7-20/h2-5,8-13,18,20H,1,6-7,14-17,19H2,(H,30,32)(H,31,35) GWETZOBRIHQHJM-UHFFFAOYSA-N 50525290 CHEMBL4547039 Dipeptidyl peptidase 1 783 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525290 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525290&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 150363449 440733872 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288624 COc1cc(ccc1Nc1ccc(C#N)c(Oc2cccc(NC(=O)C=C)c2)n1)N1CCN(C)CC1 InChI=1S/C27H28N6O3/c1-4-26(34)29-20-6-5-7-22(16-20)36-27-19(18-28)8-11-25(31-27)30-23-10-9-21(17-24(23)35-3)33-14-12-32(2)13-15-33/h4-11,16-17H,1,12-15H2,2-3H3,(H,29,34)(H,30,31) WWKMFIGDHGSHGC-UHFFFAOYSA-N 50525291 CHEMBL4587551 Dipeptidyl peptidase 1 835 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525291 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525291&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 152335936 440733873 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288625 COc1cc(ccc1Nc1ccc(N(C)C)c(Oc2cccc(NC(=O)C=C)c2)n1)N1CCN(C)CC1 InChI=1S/C28H34N6O3/c1-6-27(35)29-20-8-7-9-22(18-20)37-28-24(32(2)3)12-13-26(31-28)30-23-11-10-21(19-25(23)36-5)34-16-14-33(4)15-17-34/h6-13,18-19H,1,14-17H2,2-5H3,(H,29,35)(H,30,31) HCUGVXANZBUVFP-UHFFFAOYSA-N 50525292 CHEMBL4586963 Dipeptidyl peptidase 1 1520 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525292 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525292&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 150396261 440733874 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288626 COc1cc(ccc1Nc1ccc(N2CCCC2)c(Oc2cccc(NC(=O)C=C)c2C)n1)N1CCN(C)CC1 InChI=1S/C31H38N6O3/c1-5-30(38)33-24-9-8-10-27(22(24)2)40-31-26(37-15-6-7-16-37)13-14-29(34-31)32-25-12-11-23(21-28(25)39-4)36-19-17-35(3)18-20-36/h5,8-14,21H,1,6-7,15-20H2,2-4H3,(H,32,34)(H,33,38) CDQCAMSPSKFQJW-UHFFFAOYSA-N 50525293 CHEMBL4534931 Dipeptidyl peptidase 1 >10000 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525293 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525293&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 147202641 440733875 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288627 COc1cc(ccc1Nc1ccc(N2CCCC2)c(Oc2cc(NC(=O)C=C)ccc2C)n1)N1CCN(C)CC1 InChI=1S/C31H38N6O3/c1-5-30(38)32-23-9-8-22(2)27(20-23)40-31-26(37-14-6-7-15-37)12-13-29(34-31)33-25-11-10-24(21-28(25)39-4)36-18-16-35(3)17-19-36/h5,8-13,20-21H,1,6-7,14-19H2,2-4H3,(H,32,38)(H,33,34) ZXQNXASBAXVTJG-UHFFFAOYSA-N 50525294 CHEMBL4575481 Dipeptidyl peptidase 1 505 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525294&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 149589615 440733876 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288628 COc1cc(ccc1Nc1ccc(N2CCCC2)c(Oc2ccc(C)c(NC(=O)C=C)c2)n1)N1CCN(C)CC1 InChI=1S/C31H38N6O3/c1-5-30(38)33-26-21-24(10-8-22(26)2)40-31-27(37-14-6-7-15-37)12-13-29(34-31)32-25-11-9-23(20-28(25)39-4)36-18-16-35(3)17-19-36/h5,8-13,20-21H,1,6-7,14-19H2,2-4H3,(H,32,34)(H,33,38) JAHBFOVLZZJYDG-UHFFFAOYSA-N 50525274 CHEMBL4465111 Dipeptidyl peptidase 1 44 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525274 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525274&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 148018738 440733856 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288629 COc1cc(ccc1Nc1ccc(N2CCOCC2)c(Oc2ccc(C)c(NC(=O)C=C)c2)n1)N1CCN(C)CC1 InChI=1S/C31H38N6O4/c1-5-30(38)33-26-21-24(8-6-22(26)2)41-31-27(37-16-18-40-19-17-37)10-11-29(34-31)32-25-9-7-23(20-28(25)39-4)36-14-12-35(3)13-15-36/h5-11,20-21H,1,12-19H2,2-4H3,(H,32,34)(H,33,38) ZFFQUKVWTLUZRB-UHFFFAOYSA-N 50525282 CHEMBL4464752 Dipeptidyl peptidase 1 59 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525282 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525282&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 149491764 440733864 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288630 COc1cc(ccc1Nc1ccc(N2CCN(C)CC2)c(Oc2ccc(C)c(NC(=O)C=C)c2)n1)N1CCN(C)CC1 InChI=1S/C32H41N7O3/c1-6-31(40)34-27-22-25(9-7-23(27)2)42-32-28(39-19-15-37(4)16-20-39)11-12-30(35-32)33-26-10-8-24(21-29(26)41-5)38-17-13-36(3)14-18-38/h6-12,21-22H,1,13-20H2,2-5H3,(H,33,35)(H,34,40) NLNKYGYNCGYYSC-UHFFFAOYSA-N 50525295 CHEMBL4541754 Dipeptidyl peptidase 1 47 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525295 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525295&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 151217326 440733877 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288631 CN1CCN(CC1)c1ccc(Nc2ccc(N3CCCCC3)c(Oc3ccc(C)c(NC(=O)C=C)c3)n2)cc1 InChI=1S/C31H38N6O2/c1-4-30(38)33-27-22-26(13-8-23(27)2)39-31-28(37-16-6-5-7-17-37)14-15-29(34-31)32-24-9-11-25(12-10-24)36-20-18-35(3)19-21-36/h4,8-15,22H,1,5-7,16-21H2,2-3H3,(H,32,34)(H,33,38) LTZMKTRBHXYEOB-UHFFFAOYSA-N 50525283 CHEMBL4458557 Dipeptidyl peptidase 1 18 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525283&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 148412521 440733865 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288632 COc1nc(ccc1Nc1ccc(N2CCCCC2)c(Oc2ccc(C)c(NC(=O)C=C)c2)n1)N1CCN(C)CC1 InChI=1S/C31H39N7O3/c1-5-29(39)33-25-21-23(10-9-22(25)2)41-31-26(37-15-7-6-8-16-37)12-13-27(34-31)32-24-11-14-28(35-30(24)40-4)38-19-17-36(3)18-20-38/h5,9-14,21H,1,6-8,15-20H2,2-4H3,(H,32,34)(H,33,39) PTEDRHAOUDENOU-UHFFFAOYSA-N 50525284 CHEMBL4463389 Dipeptidyl peptidase 1 29 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525284&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 148967294 440733866 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288633 COc1cc(ccc1Nc1ccc(N2CCCCC2)c(Oc2ccc(C)c(NC(=O)C=C)c2)n1)N1CCN(CC1)C(C)=O InChI=1S/C33H40N6O4/c1-5-32(41)35-28-22-26(11-9-23(28)2)43-33-29(39-15-7-6-8-16-39)13-14-31(36-33)34-27-12-10-25(21-30(27)42-4)38-19-17-37(18-20-38)24(3)40/h5,9-14,21-22H,1,6-8,15-20H2,2-4H3,(H,34,36)(H,35,41) WAEPBKNAOMKRAT-UHFFFAOYSA-N 50525296 CHEMBL4575149 Dipeptidyl peptidase 1 135 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525296 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525296&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 152225461 440733878 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288634 COc1cc(ccc1Nc1ccc(N2CCCCC2)c(Oc2ccc(c(NC(=O)C=C)c2)C(F)(F)F)n1)N1CCN(C)CC1 InChI=1S/C32H37F3N6O3/c1-4-30(42)37-26-21-23(9-10-24(26)32(33,34)35)44-31-27(41-14-6-5-7-15-41)12-13-29(38-31)36-25-11-8-22(20-28(25)43-3)40-18-16-39(2)17-19-40/h4,8-13,20-21H,1,5-7,14-19H2,2-3H3,(H,36,38)(H,37,42) SUGZGJPNARHPMK-UHFFFAOYSA-N 50525273 CHEMBL4465060 Dipeptidyl peptidase 1 2.3 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525273 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525273&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 152823047 440733855 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288635 COc1cc(ccc1Nc1ncc(Cl)c(Oc2cccc(NC(=O)C=C)c2)n1)N1CCN(C)CC1 InChI=1S/C25H27ClN6O3/c1-4-23(33)28-17-6-5-7-19(14-17)35-24-20(26)16-27-25(30-24)29-21-9-8-18(15-22(21)34-3)32-12-10-31(2)11-13-32/h4-9,14-16H,1,10-13H2,2-3H3,(H,28,33)(H,27,29,30) ITTRLTNMFYIYPA-UHFFFAOYSA-N 50383274 CHEMBL1229592::US10167264, WZ4002::US9670213, WZ4002 Dipeptidyl peptidase 1 2100 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50383274 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50383274&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 0UN 7ZYN,5X2K,3IKA 44607530 160862357 61400 CHEMBL1229592 ZINC52509385 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288636 COc1ccc(Oc2nc(Nc3ccc(cc3OC)N3CCN(C)CC3)ccc2N2CCCC2)cc1NC(=O)C=C InChI=1S/C31H38N6O4/c1-5-30(38)33-25-21-23(9-12-27(25)39-3)41-31-26(37-14-6-7-15-37)11-13-29(34-31)32-24-10-8-22(20-28(24)40-4)36-18-16-35(2)17-19-36/h5,8-13,20-21H,1,6-7,14-19H2,2-4H3,(H,32,34)(H,33,38) WDPRWBSLRSAWMZ-UHFFFAOYSA-N 50525279 CHEMBL4560030 Dipeptidyl peptidase 1 70 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525279&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 152242423 440733861 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288637 COc1cc(ccc1Nc1ccc(N2CCCCC2)c(Oc2ccc(C)c(NC(=O)C=C)c2)n1)N1CCN(C)CC1 InChI=1S/C32H40N6O3/c1-5-31(39)34-27-22-25(11-9-23(27)2)41-32-28(38-15-7-6-8-16-38)13-14-30(35-32)33-26-12-10-24(21-29(26)40-4)37-19-17-36(3)18-20-37/h5,9-14,21-22H,1,6-8,15-20H2,2-4H3,(H,33,35)(H,34,39) ZFRMQNBHXVYHCH-UHFFFAOYSA-N 50525275 CHEMBL4540948 Dipeptidyl peptidase 1 3.4 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525275 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525275&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 149494192 440733857 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288638 COc1cc(ccc1Nc1ccc(N2CCCC(O)C2)c(Oc2ccc(C)c(NC(=O)C=C)c2)n1)N1CCN(C)CC1 InChI=1S/C32H40N6O4/c1-5-31(40)34-27-20-25(10-8-22(27)2)42-32-28(38-14-6-7-24(39)21-38)12-13-30(35-32)33-26-11-9-23(19-29(26)41-4)37-17-15-36(3)16-18-37/h5,8-13,19-20,24,39H,1,6-7,14-18,21H2,2-4H3,(H,33,35)(H,34,40) NVVMUQZCIADBFK-UHFFFAOYSA-N 50525280 CHEMBL4578535 Dipeptidyl peptidase 1 7.4 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525280 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525280&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 151268438 440733862 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288639 COc1cc(ccc1Nc1ccc(N2CCN(C)CC2)c(Oc2ccc(C)c(NC(=O)C=C)c2)n1)N1CCN(C)CC1 InChI=1S/C32H41N7O3/c1-6-31(40)34-27-22-25(9-7-23(27)2)42-32-28(39-19-15-37(4)16-20-39)11-12-30(35-32)33-26-10-8-24(21-29(26)41-5)38-17-13-36(3)14-18-38/h6-12,21-22H,1,13-20H2,2-5H3,(H,33,35)(H,34,40) NLNKYGYNCGYYSC-UHFFFAOYSA-N 50525295 CHEMBL4541754 Dipeptidyl peptidase 1 4.7 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525295 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525295&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 151217326 440733877 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288640 CN1CCN(CC1)c1ccc(Nc2ccc(N3CCCCC3)c(Oc3ccc(C)c(NC(=O)C=C)c3)n2)cc1 InChI=1S/C31H38N6O2/c1-4-30(38)33-27-22-26(13-8-23(27)2)39-31-28(37-16-6-5-7-17-37)14-15-29(34-31)32-24-9-11-25(12-10-24)36-20-18-35(3)19-21-36/h4,8-15,22H,1,5-7,16-21H2,2-3H3,(H,32,34)(H,33,38) LTZMKTRBHXYEOB-UHFFFAOYSA-N 50525283 CHEMBL4458557 Dipeptidyl peptidase 1 5.8 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525283&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 148412521 440733865 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288641 COc1cc(ccc1Nc1ccc(N2CCCC2)c(Oc2ccc(c(NC(=O)C=C)c2)C(F)(F)F)n1)N1CCN(C)CC1 InChI=1S/C31H35F3N6O3/c1-4-29(41)36-25-20-22(8-9-23(25)31(32,33)34)43-30-26(40-13-5-6-14-40)11-12-28(37-30)35-24-10-7-21(19-27(24)42-3)39-17-15-38(2)16-18-39/h4,7-12,19-20H,1,5-6,13-18H2,2-3H3,(H,35,37)(H,36,41) DAFUUYWXBRQLNF-UHFFFAOYSA-N 50525297 CHEMBL4567974 Dipeptidyl peptidase 1 12 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525297&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 147323358 440733879 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288642 COc1cc(ccc1Nc1ccc(Cl)c(Oc2cccc(NC(=O)C=C)c2)n1)N1CCN(C)CC1 InChI=1S/C26H28ClN5O3/c1-4-25(33)28-18-6-5-7-20(16-18)35-26-21(27)9-11-24(30-26)29-22-10-8-19(17-23(22)34-3)32-14-12-31(2)13-15-32/h4-11,16-17H,1,12-15H2,2-3H3,(H,28,33)(H,29,30) VMMYPYDOTNDREB-UHFFFAOYSA-N 50525298 CHEMBL4515293 Dipeptidyl peptidase 1 810 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525298&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 152157601 440733880 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288643 NCc1cccc(Nc2ccc(Cl)c(Oc3cccc(NC(=O)C=C)c3)n2)c1 InChI=1S/C21H19ClN4O2/c1-2-20(27)25-16-7-4-8-17(12-16)28-21-18(22)9-10-19(26-21)24-15-6-3-5-14(11-15)13-23/h2-12H,1,13,23H2,(H,24,26)(H,25,27) CLEOVONGQOWYOP-UHFFFAOYSA-N 50525299 CHEMBL4470893 Dipeptidyl peptidase 1 2150 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525299 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525299&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 147243243 440733881 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288644 COc1cc(ccc1Nc1ccc(C#C)c(Oc2cccc(NC(=O)C=C)c2)n1)N1CCN(C)CC1 InChI=1S/C28H29N5O3/c1-5-20-10-13-26(31-28(20)36-23-9-7-8-21(18-23)29-27(34)6-2)30-24-12-11-22(19-25(24)35-4)33-16-14-32(3)15-17-33/h1,6-13,18-19H,2,14-17H2,3-4H3,(H,29,34)(H,30,31) XUSBCYKPDREHOP-UHFFFAOYSA-N 50525300 CHEMBL4447034 Dipeptidyl peptidase 1 392 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525300&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 152457310 440733882 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288645 COc1cc(ccc1Nc1ccc(N2CCCCC2)c(Oc2cccc(NC(=O)C=C)c2)n1)N1CCN(C)CC1 InChI=1S/C31H38N6O3/c1-4-30(38)32-23-9-8-10-25(21-23)40-31-27(37-15-6-5-7-16-37)13-14-29(34-31)33-26-12-11-24(22-28(26)39-3)36-19-17-35(2)18-20-36/h4,8-14,21-22H,1,5-7,15-20H2,2-3H3,(H,32,38)(H,33,34) LNKCHNIZIPLRTG-UHFFFAOYSA-N 50525301 CHEMBL4449155 Dipeptidyl peptidase 1 221 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525301 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525301&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 150967523 440733883 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288646 COc1cc(ccc1Nc1ccc(N2CCC(O)C2)c(Oc2ccc(C)c(NC(=O)C=C)c2)n1)N1CCN(C)CC1 InChI=1S/C31H38N6O4/c1-5-30(39)33-26-19-24(8-6-21(26)2)41-31-27(37-13-12-23(38)20-37)10-11-29(34-31)32-25-9-7-22(18-28(25)40-4)36-16-14-35(3)15-17-36/h5-11,18-19,23,38H,1,12-17,20H2,2-4H3,(H,32,34)(H,33,39) PONPXMDPXUKJAO-UHFFFAOYSA-N 50525281 CHEMBL4456214 Dipeptidyl peptidase 1 32 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525281&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 146685679 440733863 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288647 COc1cc(ccc1Nc1ccc(c(Oc2ccc(C)c(NC(=O)C=C)c2)n1)-c1ccccc1)N1CCN(C)CC1 InChI=1S/C33H35N5O3/c1-5-32(39)35-29-22-26(13-11-23(29)2)41-33-27(24-9-7-6-8-10-24)14-16-31(36-33)34-28-15-12-25(21-30(28)40-4)38-19-17-37(3)18-20-38/h5-16,21-22H,1,17-20H2,2-4H3,(H,34,36)(H,35,39) DSQZWPCNUFATOQ-UHFFFAOYSA-N 50525302 CHEMBL4450731 Dipeptidyl peptidase 1 154 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525302 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525302&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 150088178 440733884 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288648 COc1cc(ccc1Nc1ccc(N2CCCC2)c(Oc2ccc(c(NC(=O)C=C)c2)C(F)(F)F)n1)N1CCN(C)CC1 InChI=1S/C31H35F3N6O3/c1-4-29(41)36-25-20-22(8-9-23(25)31(32,33)34)43-30-26(40-13-5-6-14-40)11-12-28(37-30)35-24-10-7-21(19-27(24)42-3)39-17-15-38(2)16-18-39/h4,7-12,19-20H,1,5-6,13-18H2,2-3H3,(H,35,37)(H,36,41) DAFUUYWXBRQLNF-UHFFFAOYSA-N 50525297 CHEMBL4567974 Dipeptidyl peptidase 1 4.0 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525297&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 147323358 440733879 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288650 COc1cc(ccc1Nc1ccc(N2CCOCC2)c(Oc2ccc(C)c(NC(=O)C=C)c2)n1)N1CCN(C)CC1 InChI=1S/C31H38N6O4/c1-5-30(38)33-26-21-24(8-6-22(26)2)41-31-27(37-16-18-40-19-17-37)10-11-29(34-31)32-25-9-7-23(20-28(25)39-4)36-14-12-35(3)13-15-36/h5-11,20-21H,1,12-19H2,2-4H3,(H,32,34)(H,33,38) ZFFQUKVWTLUZRB-UHFFFAOYSA-N 50525282 CHEMBL4464752 Dipeptidyl peptidase 1 5.9 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525282 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525282&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 149491764 440733864 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288651 COc1cc(ccc1Nc1ccc(N2CCCCC2)c(Oc2ccc(c(NC(=O)C=C)c2)C(F)(F)F)n1)N1CCN(C)CC1 InChI=1S/C32H37F3N6O3/c1-4-30(42)37-26-21-23(9-10-24(26)32(33,34)35)44-31-27(41-14-6-5-7-15-41)12-13-29(38-31)36-25-11-8-22(20-28(25)43-3)40-18-16-39(2)17-19-40/h4,8-13,20-21H,1,5-7,14-19H2,2-3H3,(H,36,38)(H,37,42) SUGZGJPNARHPMK-UHFFFAOYSA-N 50525273 CHEMBL4465060 Dipeptidyl peptidase 1 2.4 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525273 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525273&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 152823047 440733855 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288652 COc1cc(ccc1Nc1ccc(N2CCCC2)c(Oc2ccc(C)c(NC(=O)C=C)c2)n1)N1CCN(C)CC1 InChI=1S/C31H38N6O3/c1-5-30(38)33-26-21-24(10-8-22(26)2)40-31-27(37-14-6-7-15-37)12-13-29(34-31)32-25-11-9-23(20-28(25)39-4)36-18-16-35(3)17-19-36/h5,8-13,20-21H,1,6-7,14-19H2,2-4H3,(H,32,34)(H,33,38) JAHBFOVLZZJYDG-UHFFFAOYSA-N 50525274 CHEMBL4465111 Dipeptidyl peptidase 1 12 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525274 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525274&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 148018738 440733856 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288653 COc1cc(ccc1Nc1ccc(N2CCN(C)CC2)c(Oc2ccc(C)c(NC(=O)C=C)c2)n1)N1CCN(C)CC1 InChI=1S/C32H41N7O3/c1-6-31(40)34-27-22-25(9-7-23(27)2)42-32-28(39-19-15-37(4)16-20-39)11-12-30(35-32)33-26-10-8-24(21-29(26)41-5)38-17-13-36(3)14-18-38/h6-12,21-22H,1,13-20H2,2-5H3,(H,33,35)(H,34,40) NLNKYGYNCGYYSC-UHFFFAOYSA-N 50525295 CHEMBL4541754 Dipeptidyl peptidase 1 2.8 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525295 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525295&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 151217326 440733877 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288654 COc1cc(ccc1Nc1ccc(N2CCCC2)c(Oc2ccc(c(NC(=O)C=C)c2)C(F)(F)F)n1)N1CCN(C)CC1 InChI=1S/C31H35F3N6O3/c1-4-29(41)36-25-20-22(8-9-23(25)31(32,33)34)43-30-26(40-13-5-6-14-40)11-12-28(37-30)35-24-10-7-21(19-27(24)42-3)39-17-15-38(2)16-18-39/h4,7-12,19-20H,1,5-6,13-18H2,2-3H3,(H,35,37)(H,36,41) DAFUUYWXBRQLNF-UHFFFAOYSA-N 50525297 CHEMBL4567974 Dipeptidyl peptidase 1 6.7 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525297&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 147323358 440733879 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288659 COc1cc(ccc1Nc1ncc(Cl)c(Oc2cccc(NC(=O)C=C)c2)n1)N1CCN(C)CC1 InChI=1S/C25H27ClN6O3/c1-4-23(33)28-17-6-5-7-19(14-17)35-24-20(26)16-27-25(30-24)29-21-9-8-18(15-22(21)34-3)32-12-10-31(2)11-13-32/h4-9,14-16H,1,10-13H2,2-3H3,(H,28,33)(H,27,29,30) ITTRLTNMFYIYPA-UHFFFAOYSA-N 50383274 CHEMBL1229592::US10167264, WZ4002::US9670213, WZ4002 Dipeptidyl peptidase 1 2100 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50383274 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50383274&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 0UN 7ZYN,5X2K,3IKA 44607530 160862357 61400 CHEMBL1229592 ZINC52509385 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288660 NC1(CCOCC1)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N InChI=1S/C22H22N4O2/c23-14-17-3-7-19(8-4-17)18-5-1-16(2-6-18)13-20(15-24)26-21(27)22(25)9-11-28-12-10-22/h1-8,20H,9-13,25H2,(H,26,27)/t20-/m0/s1 NNUFRZJZOXVZIT-FQEVSTJZSA-N 50011502 CHEMBL3261926 Dipeptidyl peptidase 1 2.9 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50011502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50011502&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 49783666 103924055 CHEMBL3261926 ZINC36271864 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288662 COc1ccc(Oc2nc(Nc3ccc(cc3OC)N3CCN(C)CC3)ccc2N2CCCC2)cc1NC(=O)C=C InChI=1S/C31H38N6O4/c1-5-30(38)33-25-21-23(9-12-27(25)39-3)41-31-26(37-14-6-7-15-37)11-13-29(34-31)32-24-10-8-22(20-28(24)40-4)36-18-16-35(2)17-19-36/h5,8-13,20-21H,1,6-7,14-19H2,2-4H3,(H,32,34)(H,33,38) WDPRWBSLRSAWMZ-UHFFFAOYSA-N 50525279 CHEMBL4560030 Dipeptidyl peptidase 1 21 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525279&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 152242423 440733861 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288665 COc1cc(ccc1Nc1ccc(N2CCCC2)c(Oc2cccc(NC(=O)C=C)c2)n1)N1CCN(C)CC1 InChI=1S/C30H36N6O3/c1-4-29(37)31-22-8-7-9-24(20-22)39-30-26(36-14-5-6-15-36)12-13-28(33-30)32-25-11-10-23(21-27(25)38-3)35-18-16-34(2)17-19-35/h4,7-13,20-21H,1,5-6,14-19H2,2-3H3,(H,31,37)(H,32,33) WOMLNSKRAQZIPG-UHFFFAOYSA-N 50525303 CHEMBL4546923 Dipeptidyl peptidase 1 175 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525303 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525303&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 152296790 440733885 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288667 COc1cc(ccc1Nc1ccc(N2CCCCC2)c(Oc2ccc(C)c(NC(=O)C=C)c2)n1)N1CCN(C)CC1 InChI=1S/C32H40N6O3/c1-5-31(39)34-27-22-25(11-9-23(27)2)41-32-28(38-15-7-6-8-16-38)13-14-30(35-32)33-26-12-10-24(21-29(26)40-4)37-19-17-36(3)18-20-37/h5,9-14,21-22H,1,6-8,15-20H2,2-4H3,(H,33,35)(H,34,39) ZFRMQNBHXVYHCH-UHFFFAOYSA-N 50525275 CHEMBL4540948 Dipeptidyl peptidase 1 1.9 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525275 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525275&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 149494192 440733857 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288670 COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1cn(C)c2ccccc12 InChI=1S/C28H33N7O2/c1-7-27(36)30-22-16-23(26(37-6)17-25(22)34(4)15-14-33(2)3)32-28-29-13-12-21(31-28)20-18-35(5)24-11-9-8-10-19(20)24/h7-13,16-18H,1,14-15H2,2-6H3,(H,30,36)(H,29,31,32) DUYJMQONPNNFPI-UHFFFAOYSA-N 50029668 AZD-9291::Osimertinib::US10085983, Compound AZD-9291::US10227342, Example 24::US11111233, Example AZD9291::US9890168, Compound AZD-9291::WO2022090481, Example osimertinib Dipeptidyl peptidase 1 32900 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50029668 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50029668&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search YY3 7JXM,7K1H,6JWL,4ZAU,7JXP,7JXW,6JXT,6JX4,6JX0,6LUD 71496458 313065691 DB09330 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288671 COc1cc(ccc1Nc1ccc(N2CCCCCC2)c(Oc2cccc(NC(=O)C=C)c2)n1)N1CCN(C)CC1 InChI=1S/C32H40N6O3/c1-4-31(39)33-24-10-9-11-26(22-24)41-32-28(38-16-7-5-6-8-17-38)14-15-30(35-32)34-27-13-12-25(23-29(27)40-3)37-20-18-36(2)19-21-37/h4,9-15,22-23H,1,5-8,16-21H2,2-3H3,(H,33,39)(H,34,35) IXZBVAOGQKMSCW-UHFFFAOYSA-N 50525304 CHEMBL4436999 Dipeptidyl peptidase 1 271 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525304 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525304&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 150631495 440733886 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288672 COc1cc(ccc1Nc1ccc(N2CCCC(O)C2)c(Oc2ccc(C)c(NC(=O)C=C)c2)n1)N1CCN(C)CC1 InChI=1S/C32H40N6O4/c1-5-31(40)34-27-20-25(10-8-22(27)2)42-32-28(38-14-6-7-24(39)21-38)12-13-30(35-32)33-26-11-9-23(19-29(26)41-4)37-17-15-36(3)16-18-37/h5,8-13,19-20,24,39H,1,6-7,14-18,21H2,2-4H3,(H,33,35)(H,34,40) NVVMUQZCIADBFK-UHFFFAOYSA-N 50525280 CHEMBL4578535 Dipeptidyl peptidase 1 34 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525280 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525280&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 151268438 440733862 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288673 COc1cc(ccc1Nc1ccc(N2CCCCC2)c(Oc2ccc(C)c(NC(=O)C=C)c2)n1)N1CCC(CC1)N(C)C InChI=1S/C34H44N6O3/c1-6-33(41)36-29-23-27(12-10-24(29)2)43-34-30(40-18-8-7-9-19-40)14-15-32(37-34)35-28-13-11-26(22-31(28)42-5)39-20-16-25(17-21-39)38(3)4/h6,10-15,22-23,25H,1,7-9,16-21H2,2-5H3,(H,35,37)(H,36,41) UAVSAGIAKWMDMK-UHFFFAOYSA-N 50525277 CHEMBL4525977 Dipeptidyl peptidase 1 16 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525277 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525277&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 151971947 440733859 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288674 COc1nc(ccc1Nc1ccc(N2CCCCC2)c(Oc2ccc(C)c(NC(=O)C=C)c2)n1)N1CCN(C)CC1 InChI=1S/C31H39N7O3/c1-5-29(39)33-25-21-23(10-9-22(25)2)41-31-26(37-15-7-6-8-16-37)12-13-27(34-31)32-24-11-14-28(35-30(24)40-4)38-19-17-36(3)18-20-38/h5,9-14,21H,1,6-8,15-20H2,2-4H3,(H,32,34)(H,33,39) PTEDRHAOUDENOU-UHFFFAOYSA-N 50525284 CHEMBL4463389 Dipeptidyl peptidase 1 10.0 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525284&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 148967294 440733866 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288675 COc1cc(ccc1Nc1ccc(N2CCCCC2)c(Oc2ccc(C)c(NC(=O)C=C)c2)n1)N1CCN(C)CC1 InChI=1S/C32H40N6O3/c1-5-31(39)34-27-22-25(11-9-23(27)2)41-32-28(38-15-7-6-8-16-38)13-14-30(35-32)33-26-12-10-24(21-29(26)40-4)37-19-17-36(3)18-20-37/h5,9-14,21-22H,1,6-8,15-20H2,2-4H3,(H,33,35)(H,34,39) ZFRMQNBHXVYHCH-UHFFFAOYSA-N 50525275 CHEMBL4540948 Dipeptidyl peptidase 1 17 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525275 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525275&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 149494192 440733857 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288676 COc1cc(ccc1Nc1ccc(N2CCC(O)C2)c(Oc2ccc(C)c(NC(=O)C=C)c2)n1)N1CCN(C)CC1 InChI=1S/C31H38N6O4/c1-5-30(39)33-26-19-24(8-6-21(26)2)41-31-27(37-13-12-23(38)20-37)10-11-29(34-31)32-25-9-7-22(18-28(25)40-4)36-16-14-35(3)15-17-36/h5-11,18-19,23,38H,1,12-17,20H2,2-4H3,(H,32,34)(H,33,39) PONPXMDPXUKJAO-UHFFFAOYSA-N 50525281 CHEMBL4456214 Dipeptidyl peptidase 1 49 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525281&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 146685679 440733863 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288678 Clc1ccc(Nc2ccc(cc2)N2CCN(CC3CCCC3)CC2)nc1Oc1cccc(NC(=O)C=C)c1 InChI=1S/C30H34ClN5O2/c1-2-29(37)33-24-8-5-9-26(20-24)38-30-27(31)14-15-28(34-30)32-23-10-12-25(13-11-23)36-18-16-35(17-19-36)21-22-6-3-4-7-22/h2,5,8-15,20,22H,1,3-4,6-7,16-19,21H2,(H,32,34)(H,33,37) CNQAXEIADQCRSJ-UHFFFAOYSA-N 50525305 CHEMBL4574636 Dipeptidyl peptidase 1 >10000 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525305 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525305&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 149933110 440733887 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288680 COc1cc(ccc1Nc1cccc(Oc2cccc(NC(=O)C=C)c2)n1)N1CCN(C)CC1 InChI=1S/C26H29N5O3/c1-4-25(32)27-19-7-5-8-21(17-19)34-26-10-6-9-24(29-26)28-22-12-11-20(18-23(22)33-3)31-15-13-30(2)14-16-31/h4-12,17-18H,1,13-16H2,2-3H3,(H,27,32)(H,28,29) SCUMUQJWOMCQLE-UHFFFAOYSA-N 50525306 CHEMBL4574925 Dipeptidyl peptidase 1 785 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525306 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525306&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 151821865 440733888 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51288681 COc1cc(ccc1Nc1ccc(Cl)c(Oc2cccc(NC(=O)C=C)c2)n1)N1CCN(C)CC1 InChI=1S/C26H28ClN5O3/c1-4-25(33)28-18-6-5-7-20(16-18)35-26-21(27)9-11-24(30-26)29-22-10-8-19(17-23(22)34-3)32-14-12-31(2)13-15-32/h4-11,16-17H,1,12-15H2,2-3H3,(H,28,33)(H,29,30) VMMYPYDOTNDREB-UHFFFAOYSA-N 50525298 CHEMBL4515293 Dipeptidyl peptidase 1 537 ChEMBL 10.1021/acs.jmedchem.9b00631 10.7270/Q2MG7SX9 31145622 Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z National Institute of Biological Sciences (NIBS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525298&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 152157601 440733880 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1096513 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)[C@@H]1CNCCCO1 InChI=1S/C22H22N4O2/c23-13-17-4-8-19(9-5-17)18-6-2-16(3-7-18)12-20(14-24)26-22(27)21-15-25-10-1-11-28-21/h2-9,20-21,25H,1,10-12,15H2,(H,26,27)/t20-,21-/m0/s1 FCRODBUNBQJNPU-SFTDATJTSA-N 50195236 CHEMBL3927609::US10287258, Example 1::US10669245, Example 1::US11117874, Example 1::US11673871, Example 34::US11680049, Example 1 Dipeptidyl peptidase 1 35.5 US Patent 10.7270/Q2Q243DZ aid1805946 US11117874 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195236&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253857 375977091 CHEMBL3927609 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1096514 Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H24N4O4/c1-27-19-12-17(7-8-20(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)21-14-25-9-2-10-30-21/h3-8,12,18,21,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,21-/m0/s1 AEXFXNFMSAAELR-RXVVDRJESA-N 50195235 CHEMBL3900409::US10287258, Example 2::US10669245, Example 2::US11117874, Example 2::US11655221, Example 2::US11680049, Example 2 Dipeptidyl peptidase 1 4.47 US Patent 10.7270/Q2Q243DZ aid1805946 US11117874 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195235&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253852 375977090 CHEMBL3900409 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1096515 Cc1cc(cc2n(C)c(=O)oc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H26N4O4/c1-15-10-18(12-20-22(15)32-24(30)28(20)2)17-6-4-16(5-7-17)11-19(13-25)27-23(29)21-14-26-8-3-9-31-21/h4-7,10,12,19,21,26H,3,8-9,11,14H2,1-2H3,(H,27,29)/t19-,21-/m0/s1 WCWJGAFMGPMBQG-FPOVZHCZSA-N 50195240 CHEMBL3960432::US10287258, Example 3::US10669245, Example 3::US11117874, Example 3::US11655221, Example 3::US11680049, Example 3 Dipeptidyl peptidase 1 10.2 US Patent 10.7270/Q2Q243DZ aid1805946 US11117874 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195240&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253824 375977095 CHEMBL3960432 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1096516 CS(=O)(=O)Oc1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C22H25N3O5S/c1-31(27,28)30-20-5-2-4-18(13-20)17-8-6-16(7-9-17)12-19(14-23)25-22(26)21-15-24-10-3-11-29-21/h2,4-9,13,19,21,24H,3,10-12,15H2,1H3,(H,25,26)/t19-,21-/m0/s1 IRYUDRJLDSHZAO-FPOVZHCZSA-N 385044 4′-[(2S)-2-Cyano-2-{[(2S)-1,4-oxazepan-2-ylcarbonyl]amino}ethyl]biphenyl-3-yl methanesulfonate::US10287258, Example 4::US10669245, Example 4::US11117874, Example 4::US11667615, Example 4::US11680049, Example 4 Dipeptidyl peptidase 1 79.4 US Patent 10.7270/Q2Q243DZ aid1805946 US11117874 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385044&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253891 404854267 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1096517 Cc1noc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H24N4O3/c1-15-20-12-18(7-8-21(20)30-27-15)17-5-3-16(4-6-17)11-19(13-24)26-23(28)22-14-25-9-2-10-29-22/h3-8,12,19,22,25H,2,9-11,14H2,1H3,(H,26,28)/t19-,22-/m0/s1 QCTYSVBOKIUUFU-UGKGYDQZSA-N 50195245 CHEMBL3972158::US10287258, Example 5::US10669245, Example 5::US11117874, Example 5::US11655221, Example 5::US11680049, Example 5 Dipeptidyl peptidase 1 16.2 US Patent 10.7270/Q2Q243DZ aid1805946 US11117874 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195245 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195245&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253855 375977100 CHEMBL3972158 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1096518 FC(F)(F)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C22H22F3N3O2/c23-22(24,25)18-8-6-17(7-9-18)16-4-2-15(3-5-16)12-19(13-26)28-21(29)20-14-27-10-1-11-30-20/h2-9,19-20,27H,1,10-12,14H2,(H,28,29)/t19-,20-/m0/s1 USBDHHJQNTYSNJ-PMACEKPBSA-N 50195255 CHEMBL3945475::US10287258, Example 6::US10669245, Example 6::US11117874, Example 6::US11655221, Example 6::US11680049, Example 6 Dipeptidyl peptidase 1 36.3 US Patent 10.7270/Q2Q243DZ aid1805946 US11117874 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195255 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195255&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253859 375977110 CHEMBL3945475 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1096519 Fc1ccc(cc1F)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C21H21F2N3O2/c22-18-7-6-16(11-19(18)23)15-4-2-14(3-5-15)10-17(12-24)26-21(27)20-13-25-8-1-9-28-20/h2-7,11,17,20,25H,1,8-10,13H2,(H,26,27)/t17-,20-/m0/s1 HSWVIXGRFREZJG-PXNSSMCTSA-N 385047 (2S)-N-[(1S)-1-Cyano-2-(3',4'-difluorobiphenyl-4-yl)ethyl]-1,4-oxazepane-2- carboxamide::US10287258, Example 7::US10669245, Example 7::US11117874, Example 7::US11655221, Example 7::US11667615, Example 7::US11680049, Example 7 Dipeptidyl peptidase 1 69.2 US Patent 10.7270/Q2Q243DZ aid1805946 US11117874 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385047&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253829 404854270 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1096520 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(nc1)C#N)C#N)[C@@H]1CNCCCO1 InChI=1S/C21H21N5O2/c22-11-18-7-6-17(13-25-18)16-4-2-15(3-5-16)10-19(12-23)26-21(27)20-14-24-8-1-9-28-20/h2-7,13,19-20,24H,1,8-10,14H2,(H,26,27)/t19-,20-/m0/s1 UZXVZQQAOVNOKG-PMACEKPBSA-N 385048 (2S)-N-{(1S)-1-Cyano-2-[4-(6-cyanopyridin-3-yl)phenyl]ethyl}-1,4-oxazepane-2- carboxamide::US10287258, Example 8::US10669245, Example 8::US11117874, Example 8::US11655221, Example 8::US11667615, Example 8::US11680049, Example 8 Dipeptidyl peptidase 1 87.1 US Patent 10.7270/Q2Q243DZ aid1805946 US11117874 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385048&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253853 404854271 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1096521 CN1C(=O)CSc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H26N4O3S/c1-28-20-12-18(7-8-22(20)32-15-23(28)29)17-5-3-16(4-6-17)11-19(13-25)27-24(30)21-14-26-9-2-10-31-21/h3-8,12,19,21,26H,2,9-11,14-15H2,1H3,(H,27,30)/t19-,21-/m0/s1 NSLGCWMFHWURGT-FPOVZHCZSA-N 385049 (2S)-N-{(1S)-1-Cyano-2-[4-(4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzothiazin-6- yl)phenyl]ethyl}-1,4-oxazepane-2-carboxamide::US10287258, Example 9::US10669245, Example 9::US11117874, Example 9::US11655221, Example 9::US11667615, Example 9::US11680049, Example 9 Dipeptidyl peptidase 1 12.9 US Patent 10.7270/Q2Q243DZ aid1805946 US11117874 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385049&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253849 404854272 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1096522 CCn1c2cc(cc(C)c2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C25H28N4O4/c1-3-29-21-13-19(11-16(2)23(21)33-25(29)31)18-7-5-17(6-8-18)12-20(14-26)28-24(30)22-15-27-9-4-10-32-22/h5-8,11,13,20,22,27H,3-4,9-10,12,15H2,1-2H3,(H,28,30)/t20-,22-/m0/s1 ORHUZDNZRYZSJO-UNMCSNQZSA-N 385050 (2S)-N-{(1S)-1-Cyano-2-[4-(3-ethyl-7-methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-5- yl)phenyl]ethyl}-1,4-oxazepane-2-carboxamide::US10287258, Example 10::US10669245, Example 10::US11117874, Example 10::US11655221, Example 10::US11680049, Example 10 Dipeptidyl peptidase 1 21.4 US Patent 10.7270/Q2Q243DZ aid1805946 US11117874 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385050&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253835 404854273 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1096523 CC(C)(O)Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C26H30N4O5/c1-26(2,33)16-30-21-13-19(8-9-22(21)35-25(30)32)18-6-4-17(5-7-18)12-20(14-27)29-24(31)23-15-28-10-3-11-34-23/h4-9,13,20,23,28,33H,3,10-12,15-16H2,1-2H3,(H,29,31)/t20-,23-/m0/s1 LRDOUIXCGZNESR-REWPJTCUSA-N 385051 (2S)-N-[(1S)-1-Cyano-2-{4-[3-(2-hydroxy-2-methylpropyl)-2-oxo-2,3-dihydro-1,3- benzoxazol-5-yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 11::US10669245, Example 11::US11117874, Example 11::US11655221, Example 11::US11667615, Example 11::US11680049, Example 11 Dipeptidyl peptidase 1 89.1 US Patent 10.7270/Q2Q243DZ aid1805946 US11117874 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385051&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253819 404854274 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1096524 FC(F)Cn1c2cc(cc(F)c2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H23F3N4O4/c25-18-9-16(10-19-22(18)35-24(33)31(19)13-21(26)27)15-4-2-14(3-5-15)8-17(11-28)30-23(32)20-12-29-6-1-7-34-20/h2-5,9-10,17,20-21,29H,1,6-8,12-13H2,(H,30,32)/t17-,20-/m0/s1 PVRGXPYTNXSTMU-PXNSSMCTSA-N 385052 (2S)-N-[(1S)-1-Cyano-2-{4-[3-(2,2-difluoroethyl)-7-fluoro-2-oxo-2,3-dihydro-1,3- benzoxazol-5-yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 12::US10669245, Example 12::US11117874, Example 12::US11655221, Example 12::US11667615, Example 12::US11680049, Example 12 Dipeptidyl peptidase 1 10.0 US Patent 10.7270/Q2Q243DZ aid1805946 US11117874 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385052&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253812 404854275 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1096525 CN(C)CCn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C26H31N5O4/c1-30(2)11-12-31-22-15-20(8-9-23(22)35-26(31)33)19-6-4-18(5-7-19)14-21(16-27)29-25(32)24-17-28-10-3-13-34-24/h4-9,15,21,24,28H,3,10-14,17H2,1-2H3,(H,29,32)/t21-,24-/m0/s1 BVHRFMZXVRJZAF-URXFXBBRSA-N 385053 (2S)-N-[(1S)-1-Cyano-2-(4-{3-[2-(dimethylamino)ethyl]-2-oxo-2,3-dihydro-1,3- benzoxazol-5-yl}pheny)ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 13::US10669245, Example 13::US11117874, Example 13::US11655221, Example 13::US11667615, Example 13::US11680049, Example 13 Dipeptidyl peptidase 1 7.24 US Patent 10.7270/Q2Q243DZ aid1805946 US11117874 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385053&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253865 404854276 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1096526 CN1C(=O)C(F)(F)c2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H24F2N4O3/c1-30-20-12-17(7-8-19(20)24(25,26)23(30)32)16-5-3-15(4-6-16)11-18(13-27)29-22(31)21-14-28-9-2-10-33-21/h3-8,12,18,21,28H,2,9-11,14H2,1H3,(H,29,31)/t18-,21-/m0/s1 SABYNPLHFAPZQF-RXVVDRJESA-N 50195242 CHEMBL3917575::US10287258, Example 14::US10669245, Example 14::US11117874, Example 14::US11655221, Example 14::US11680049, Example 14 Dipeptidyl peptidase 1 16.6 US Patent 10.7270/Q2Q243DZ aid1805946 US11117874 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195242&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253811 375977097 CHEMBL3917575 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1096527 Cn1c2cc(cc(F)c2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H23FN4O4/c1-28-19-11-16(10-18(24)21(19)32-23(28)30)15-5-3-14(4-6-15)9-17(12-25)27-22(29)20-13-26-7-2-8-31-20/h3-6,10-11,17,20,26H,2,7-9,13H2,1H3,(H,27,29)/t17-,20-/m0/s1 IVHOZTBKWBUDMJ-PXNSSMCTSA-N 385055 (2S)-N-{(1S)-1-Cyano-2-[4-(7-fluoro-3-methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-5- yl)phenyl]ethyl}-1,4-oxazepane-2-carboxamide::US10287258, Example 15::US10669245, Example 15::US11117874, Example 15::US11655221, Example 15::US11667615, Example 15::US11680049, Example 15 Dipeptidyl peptidase 1 5.13 US Patent 10.7270/Q2Q243DZ aid1805946 US11117874 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385055&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253861 404854278 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1096528 CCn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H26N4O4/c1-2-28-20-13-18(8-9-21(20)32-24(28)30)17-6-4-16(5-7-17)12-19(14-25)27-23(29)22-15-26-10-3-11-31-22/h4-9,13,19,22,26H,2-3,10-12,15H2,1H3,(H,27,29)/t19-,22-/m0/s1 HZZYFVOLMKQYKP-UGKGYDQZSA-N 50195246 CHEMBL3980602::US10287258, Example 16::US10669245, Example 16::US11117874, Example 16::US11655221, Example 16 Dipeptidyl peptidase 1 5.75 US Patent 10.7270/Q2Q243DZ aid1805946 US11117874 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195246 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195246&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253883 375977101 CHEMBL3980602 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1096529 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2oc(=O)n(CC3CC3)c2c1)C#N)[C@@H]1CNCCCO1 InChI=1S/C26H28N4O4/c27-14-21(29-25(31)24-15-28-10-1-11-33-24)12-17-4-6-19(7-5-17)20-8-9-23-22(13-20)30(26(32)34-23)16-18-2-3-18/h4-9,13,18,21,24,28H,1-3,10-12,15-16H2,(H,29,31)/t21-,24-/m0/s1 WJXGZWWSCFPECN-URXFXBBRSA-N 385057 (2S)-N-[(1S)-1-Cyano-2-{4-[3-(cyclopropylmethyl)-2-oxo-2,3-dihydro-1,3-benzoxazol- 5-yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 17::US10669245, Example 17::US11117874, Example 17::US11655221, Example 17::US11667615, Example 17::US11680049, Example 17 Dipeptidyl peptidase 1 6.31 US Patent 10.7270/Q2Q243DZ aid1805946 US11117874 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385057&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253827 404854280 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1096530 COCCn1c2cc(ccc2sc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C25H28N4O4S/c1-32-12-10-29-21-14-19(7-8-23(21)34-25(29)31)18-5-3-17(4-6-18)13-20(15-26)28-24(30)22-16-27-9-2-11-33-22/h3-8,14,20,22,27H,2,9-13,16H2,1H3,(H,28,30)/t20-,22-/m0/s1 GRJJVLYWMJAVMA-UNMCSNQZSA-N 385058 (2S)-N-[(1S)-1-Cyano-2-{4-[3-(2-methoxyethyl)-2-oxo-2,3-dihydro-1,3-benzothiazol- 5-yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 18::US10669245, Example 18::US11117874, Example 18::US11655221, Example 18::US11667615, Example 18::US11680049, Example 18 Dipeptidyl peptidase 1 3.16 US Patent 10.7270/Q2Q243DZ aid1805946 US11117874 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385058&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253842 404854281 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1096531 CC(C)n1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C25H28N4O4/c1-16(2)29-21-13-19(8-9-22(21)33-25(29)31)18-6-4-17(5-7-18)12-20(14-26)28-24(30)23-15-27-10-3-11-32-23/h4-9,13,16,20,23,27H,3,10-12,15H2,1-2H3,(H,28,30)/t20-,23-/m0/s1 WOBKXJRTDASPHQ-REWPJTCUSA-N 385059 (2S)-N- [(1S)-1-Cyano-2-{4-[2-oxo-3-(propan-2-yl)-2,3-dihydro-1,3-benzoxazol-5- yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 19::US10669245, Example 19::US11117874, Example 19::US11655221, Example 19::US11667615, Example 19::US11680049, Example 19 Dipeptidyl peptidase 1 14.5 US Patent 10.7270/Q2Q243DZ aid1805946 US11117874 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385059&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253878 404854282 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1096532 CN1C(=O)COc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H26N4O4/c1-28-20-12-18(7-8-21(20)32-15-23(28)29)17-5-3-16(4-6-17)11-19(13-25)27-24(30)22-14-26-9-2-10-31-22/h3-8,12,19,22,26H,2,9-11,14-15H2,1H3,(H,27,30)/t19-,22-/m0/s1 QKDQSHLZLZUQOA-UGKGYDQZSA-N 50195238 CHEMBL3962926::US10287258, Example 20::US10669245, Example 20::US11117874, Example 20::US11655221, Example 20::US11680049, Example 20 Dipeptidyl peptidase 1 12.6 US Patent 10.7270/Q2Q243DZ aid1805946 US11117874 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195238 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195238&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253870 375977093 CHEMBL3962926 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1096533 COCCn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C25H28N4O5/c1-32-12-10-29-21-14-19(7-8-22(21)34-25(29)31)18-5-3-17(4-6-18)13-20(15-26)28-24(30)23-16-27-9-2-11-33-23/h3-8,14,20,23,27H,2,9-13,16H2,1H3,(H,28,30)/t20-,23-/m0/s1 JUXOTDAODWSCQS-REWPJTCUSA-N 385061 (2S)-N-[(1S)-1-Cyano-2-{4-[3-(2-methoxyethyl)-2-oxo-2,3-dihydro-1,3-benzoxazol-5- yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 21::US10669245, Example 21::US11117874, Example 21::US11655221, Example 21::US11667615, Example 21::US11680049, Example 21 Dipeptidyl peptidase 1 8.13 US Patent 10.7270/Q2Q243DZ aid1805946 US11117874 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385061&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253879 404854284 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1096534 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(s1)C#N)C#N)[C@@H]1CNCCCO1 InChI=1S/C20H20N4O2S/c21-11-16(24-20(25)18-13-23-8-1-9-26-18)10-14-2-4-15(5-3-14)19-7-6-17(12-22)27-19/h2-7,16,18,23H,1,8-10,13H2,(H,24,25)/t16-,18-/m0/s1 AYKAKRZDQIFHMD-WMZOPIPTSA-N 385062 (2S)-N-{(1S)-1-Cyano-2-[4-(5-cyanothiophen-2-yl)phenyl]ethyl}-1,4-oxazepane-2- carboxamide::US10287258, Example 22::US10669245, Example 22::US11117874, Example 22::US11655221, Example 22::US11667615, Example 22::US11680049, Example 22 Dipeptidyl peptidase 1 19.5 US Patent 10.7270/Q2Q243DZ aid1805946 US11117874 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385062&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253837 404854285 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1096535 NC(=O)c1ccc(cc1F)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C22H23FN4O3/c23-19-11-16(6-7-18(19)21(25)28)15-4-2-14(3-5-15)10-17(12-24)27-22(29)20-13-26-8-1-9-30-20/h2-7,11,17,20,26H,1,8-10,13H2,(H2,25,28)(H,27,29)/t17-,20-/m0/s1 GCGGEFOSHQPZEX-PXNSSMCTSA-N 385063 (2S)-N-[(1S)-2-(4'-Carbamoy1-3'-fluorobiphenyl-4-yl)-1-cyanoethyl]-1,4-oxazepane-2- carboxamide::US10287258, Example 23::US10669245, Example 23::US11117874, Example 23::US11655221, Example 23::US11667615, Example 23::US11680049, Example 23 Dipeptidyl peptidase 1 67.6 US Patent 10.7270/Q2Q243DZ aid1805946 US11117874 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385063&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253894 404854286 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1096536 Cn1c2cc(ccc2ccc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C25H26N4O3/c1-29-22-14-20(8-7-19(22)9-10-24(29)30)18-5-3-17(4-6-18)13-21(15-26)28-25(31)23-16-27-11-2-12-32-23/h3-10,14,21,23,27H,2,11-13,16H2,1H3,(H,28,31)/t21-,23-/m0/s1 BQIZWZAQEICNDG-GMAHTHKFSA-N 50195244 CHEMBL3926554::US10287258, Example 24::US10669245, Example 24::US11117874, Example 24::US11655221, Example 24::US11680049, Example 24 Dipeptidyl peptidase 1 13.8 US Patent 10.7270/Q2Q243DZ aid1805946 US11117874 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195244&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253851 375977099 CHEMBL3926554 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1096537 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2oc(=O)n(CC3CCOCC3)c2c1)C#N)[C@@H]1CNCCCO1 InChI=1S/C28H32N4O5/c29-16-23(31-27(33)26-17-30-10-1-11-36-26)14-19-2-4-21(5-3-19)22-6-7-25-24(15-22)32(28(34)37-25)18-20-8-12-35-13-9-20/h2-7,15,20,23,26,30H,1,8-14,17-18H2,(H,31,33)/t23-,26-/m0/s1 KFOHIWSKADTAQW-OZXSUGGESA-N 385065 (2S)-N-[(1S)-1-Cyano-2-{4-[2-oxo-3-(tetrahydro-2H-pyran-4-ylmethyl)-2,3-dihydro- 1,3-benzoxazol-5-yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 25::US10669245, Example 25::US11117874, Example 25::US11655221, Example 25::US11667615, Example 25::US11680049, Example 25 Dipeptidyl peptidase 1 10.7 US Patent 10.7270/Q2Q243DZ aid1805946 US11117874 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385065&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253876 404854288 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1096538 Cn1c2cc(cc(Cl)c2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H23ClN4O4/c1-28-19-11-16(10-18(24)21(19)32-23(28)30)15-5-3-14(4-6-15)9-17(12-25)27-22(29)20-13-26-7-2-8-31-20/h3-6,10-11,17,20,26H,2,7-9,13H2,1H3,(H,27,29)/t17-,20-/m0/s1 KTGYWWMCWUTXTI-PXNSSMCTSA-N 385066 (2S)-N-{(1S)-2-[4-(7-Chloro-3-methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)phenyl]- 1-cyanoethyl}-1,4-oxazepane-2-carboxamide::US10287258, Example 26::US10669245, Example 26::US11117874, Example 26::US11655221, Example 26::US11667615, Example 26::US11680049, Example 26 Dipeptidyl peptidase 1 13.5 US Patent 10.7270/Q2Q243DZ aid1805946 US11117874 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385066&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253874 404854289 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1096539 FC(F)Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H24F2N4O4/c25-22(26)14-30-19-11-17(6-7-20(19)34-24(30)32)16-4-2-15(3-5-16)10-18(12-27)29-23(31)21-13-28-8-1-9-33-21/h2-7,11,18,21-22,28H,1,8-10,13-14H2,(H,29,31)/t18-,21-/m0/s1 ANPJTTUBCRFBKA-RXVVDRJESA-N 50195248 CHEMBL3891374::US10287258, Example 27::US10669245, Example 27::US11117874, Example 27::US11655221, Example 27::US11680049, Example 27 Dipeptidyl peptidase 1 6.61 US Patent 10.7270/Q2Q243DZ aid1805946 US11117874 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195248 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195248&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253888 375977103 CHEMBL3891374 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1096540 FC(F)(F)Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H23F3N4O4/c25-24(26,27)14-31-19-11-17(6-7-20(19)35-23(31)33)16-4-2-15(3-5-16)10-18(12-28)30-22(32)21-13-29-8-1-9-34-21/h2-7,11,18,21,29H,1,8-10,13-14H2,(H,30,32)/t18-,21-/m0/s1 KAGSLWGZQVTFPB-RXVVDRJESA-N 385068 (2S)-N-[(1S)-1-Cyano-2-{4-[2-oxo-3-(2,2,2-trifluoroethyl)-2,3-dihydro-1,3- benzoxazol-5-yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 28::US10669245, Example 28::US11117874, Example 28::US11655221, Example 28::US11667615, Example 28::US11680049, Example 28 Dipeptidyl peptidase 1 8.13 US Patent 10.7270/Q2Q243DZ aid1805946 US11117874 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385068&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253867 404854291 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1096541 Cn1c2cc(ccc2sc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H24N4O3S/c1-27-19-12-17(7-8-21(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)20-14-25-9-2-10-30-20/h3-8,12,18,20,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,20-/m0/s1 DRQDONWWFWYTII-ICSRJNTNSA-N 50195239 CHEMBL3972563::US10287258, Example 29::US10669245, Example 29::US11117874, Example 29::US11655221, Example 29::US11680049, Example 29 Dipeptidyl peptidase 1 2.40 US Patent 10.7270/Q2Q243DZ aid1805946 US11117874 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195239&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91826235 375977094 CHEMBL3972563 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1096542 CS(=O)(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C22H25N3O4S/c1-30(27,28)20-9-7-18(8-10-20)17-5-3-16(4-6-17)13-19(14-23)25-22(26)21-15-24-11-2-12-29-21/h3-10,19,21,24H,2,11-13,15H2,1H3,(H,25,26)/t19-,21-/m0/s1 UBRDXNDHEGQOTI-FPOVZHCZSA-N 385070 (2S)-N-{(1S)-1-Cyano-2-[4'-(methylsulfonyl)bipheny1-4-yl]ethyl}-1,4-oxazepane-2- carboxamide::US10287258, Example 30::US10669245, Example 30::US11117874, Example 30::US11655221, Example 30::US11667615, Example 30::US11680049, Example 30 Dipeptidyl peptidase 1 37.2 US Patent 10.7270/Q2Q243DZ aid1805946 US11117874 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385070&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253895 404854293 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1096543 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N1CCC1)C#N)[C@@H]1CNCCCO1 InChI=1S/C24H28N4O4S/c25-16-21(27-24(29)23-17-26-11-1-14-32-23)15-18-3-5-19(6-4-18)20-7-9-22(10-8-20)33(30,31)28-12-2-13-28/h3-10,21,23,26H,1-2,11-15,17H2,(H,27,29)/t21-,23-/m0/s1 CBWWXOUBSQCMHB-GMAHTHKFSA-N 385071 (2S)-N-{(1S)-2-[4'-(Azetidin-1-ylsulfonyl)biphenyl-4-yl]-1-cyanoethyl}-1,4-oxazepane- 2-carboxamide::US10287258, Example 31::US10669245, Example 31::US11117874, Example 31::US11655221, Example 31::US11667615, Example 31::US11680049, Example 31 Dipeptidyl peptidase 1 21.4 US Patent 10.7270/Q2Q243DZ aid1805946 US11117874 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385071&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253890 404854294 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1096544 Fc1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C21H22FN3O2/c22-18-8-6-17(7-9-18)16-4-2-15(3-5-16)12-19(13-23)25-21(26)20-14-24-10-1-11-27-20/h2-9,19-20,24H,1,10-12,14H2,(H,25,26)/t19-,20-/m0/s1 PYXGGJVWIVBQRO-PMACEKPBSA-N 385072 (2S)-N-[(1S)-1-Cyano-2-(4'-fluorobiphenyl-4-yl)ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 32::US10669245, Example 32::US11117874, Example 32::US11655221, Example 32::US11667615, Example 32::US11680049, Example 32 Dipeptidyl peptidase 1 42.7 US Patent 10.7270/Q2Q243DZ aid1805946 US11117874 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385072&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253858 404854295 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1096545 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2scnc2c1)C#N)[C@@H]1CNCCCO1 InChI=1S/C22H22N4O2S/c23-12-18(26-22(27)20-13-24-8-1-9-28-20)10-15-2-4-16(5-3-15)17-6-7-21-19(11-17)25-14-29-21/h2-7,11,14,18,20,24H,1,8-10,13H2,(H,26,27)/t18-,20-/m0/s1 MUTKXUKCDAFWLB-ICSRJNTNSA-N 50195263 CHEMBL3942969::US10287258, Example 33::US10669245, Example 33::US11117874, Example 33::US11673871, Example 33::US11680049, Example 33 Dipeptidyl peptidase 1 61.7 US Patent 10.7270/Q2Q243DZ aid1805946 US11117874 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195263&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253877 375977118 CHEMBL3942969 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1096546 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)C1CNCCCO1 InChI=1S/C22H22N4O2/c23-13-17-4-8-19(9-5-17)18-6-2-16(3-7-18)12-20(14-24)26-22(27)21-15-25-10-1-11-28-21/h2-9,20-21,25H,1,10-12,15H2,(H,26,27)/t20-,21?/m0/s1 FCRODBUNBQJNPU-BGERDNNASA-N 385074 US10287258, Example 34::US10669245, Example 34::US11117874, Example 34::US11667615, Example 34::US11680049, Example 34 Dipeptidyl peptidase 1 60.3 US Patent 10.7270/Q2Q243DZ aid1805946 US11117874 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385074&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118260121 404854297 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1096547 CN1C(=O)CNc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H27N5O3/c1-29-21-12-18(7-8-20(21)27-15-23(29)30)17-5-3-16(4-6-17)11-19(13-25)28-24(31)22-14-26-9-2-10-32-22/h3-8,12,19,22,26-27H,2,9-11,14-15H2,1H3,(H,28,31)/t19-,22-/m0/s1 CPBDCTBYFQTDMV-UGKGYDQZSA-N 385075 US10287258, Example 35::US10669245, Example 35::US11117874, Example 35::US11673871, Example 35::US11680049, Example 35 Dipeptidyl peptidase 1 24.5 US Patent 10.7270/Q2Q243DZ aid1805946 US11117874 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385075&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253822 404854298 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1096548 CC[C@H](NC(=O)[C@@H]1CNCCCO1)\C=C\C(=O)N1CCc2ccccc12 InChI=1S/C20H27N3O3/c1-2-16(22-20(25)18-14-21-11-5-13-26-18)8-9-19(24)23-12-10-15-6-3-4-7-17(15)23/h3-4,6-9,16,18,21H,2,5,10-14H2,1H3,(H,22,25)/b9-8+/t16-,18-/m0/s1 OHNHQTNQBQMALV-LFGVRAQPSA-N 385076 BDBM445984::US10287258, Example 36::US11667615, Example 36::US11680049, Example 36 Dipeptidyl peptidase 1 5.01 US Patent 10.7270/Q2Q243DZ aid1805947 US11117874 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385076&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 144891673 404854299 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1096549 CC(C)C[C@H](NC(=O)[C@@H]1CNCCCO1)\C=C\C(=O)N1CCc2ccccc12 InChI=1S/C22H31N3O3/c1-16(2)14-18(24-22(27)20-15-23-11-5-13-28-20)8-9-21(26)25-12-10-17-6-3-4-7-19(17)25/h3-4,6-9,16,18,20,23H,5,10-15H2,1-2H3,(H,24,27)/b9-8+/t18-,20+/m1/s1 PXFMGAFAIVURSO-ZZHWGSSASA-N 385077 BDBM445985::US10287258, Example 37::US11667615, Example 37::US11680049, Example 37 Dipeptidyl peptidase 1 5.25 US Patent 10.7270/Q2Q243DZ aid1805947 US11117874 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ ASTRAZENECA AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385077&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 144891689 404854300 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51350745 CC[C@H](N)C(=O)N[C@@]1(C[C@@H]1c1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N1CCN(C)CC1)C#N InChI=1S/C25H31N5O3S/c1-3-23(27)24(31)28-25(17-26)16-22(25)20-6-4-18(5-7-20)19-8-10-21(11-9-19)34(32,33)30-14-12-29(2)13-15-30/h4-11,22-23H,3,12-16,27H2,1-2H3,(H,28,31)/t22-,23+,25+/m1/s1 LJIOTBMDLVHTBO-CUYJMHBOSA-N 50546373 CHEMBL4764657 Dipeptidyl peptidase 1 15 ChEMBL 10.1021/acs.jmedchem.0c00776 10.7270/Q2SX6HT9 32692176 Korkmaz, B; Lesner, A; Marchand-Adam, S; Moss, C; Jenne, DE Centre d'Etude des Pathologies Respiratoires and Universit£ de Tours http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50546373 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50546373&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 66550979 461690136 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51372405 CO[C@@H](C)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12 InChI=1S/C17H15Cl2N9O2/c1-9(30-2)15-12(8-20-14-6-13(19)26-27(14)15)25-17(29)24-10-5-11(18)16(21-7-10)28-22-3-4-23-28/h3-9H,1-2H3,(H2,24,25,29)/t9-/m0/s1 GBIASRXDYFFUED-VIFPVBQESA-N 355886 (S)-1-(5-chloro-6- (2H-1,2,3-triazol-2- yl)pyridin-3-yl)-3-(2- chloro-7-(1- methoxyethyl)pyrazo- lo[1,5-a]pyrimidin-6- yl)urea::US10442808, Example 10::US9815842, Example 10 Dipeptidyl peptidase 1 >100000 ChEMBL 10.1021/acs.jmedchem.0c01246 10.7270/Q2DZ0CZ3 33216547 Quancard, J; Simic, O; Pissot Soldermann, C; Aichholz, R; Blatter, M; Renatus, M; Erbel, P; Melkko, S; Endres, R; Sorge, M; Kieffer, L; Wagner, T; Beltz, K; Mcsheehy, P; Wartmann, M; Régnier, CH; Calzascia, T; Radimerski, T; Bigaud, M; Weiss, A; Bornancin, F; Schlapbach, A Novartis Pharma AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=355886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=355886&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 129072335 386395486 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1312853 FC(F)Cn1c2cc(cc(F)c2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H23F3N4O4/c25-18-9-16(10-19-22(18)35-24(33)31(19)13-21(26)27)15-4-2-14(3-5-15)8-17(11-28)30-23(32)20-12-29-6-1-7-34-20/h2-5,9-10,17,20-21,29H,1,6-8,12-13H2,(H,30,32)/t17-,20-/m0/s1 PVRGXPYTNXSTMU-PXNSSMCTSA-N 385052 (2S)-N-[(1S)-1-Cyano-2-{4-[3-(2,2-difluoroethyl)-7-fluoro-2-oxo-2,3-dihydro-1,3- benzoxazol-5-yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 12::US10669245, Example 12::US11117874, Example 12::US11655221, Example 12::US11667615, Example 12::US11680049, Example 12::US20230278969, Example 12 Dipeptidyl peptidase 1 10.0 US Patent 10.7270/Q24X5CXQ US20230278969 LONN, HR; CONNOLLY, S; SWALLOW, S; KARLSSON, SP; AURELL, C; PONTÉN, JF; DOYLE, KJ; VAN DE POËL, AJ; JONES, GP; WATSON, DW; MACRITCHIE, JA; PALMER, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385052&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253812 404854275 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1312854 CN(C)CCn1c2cc(cc(F)c2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C26H30FN5O4/c1-31(2)9-10-32-22-14-19(13-21(27)24(22)36-26(32)34)18-6-4-17(5-7-18)12-20(15-28)30-25(33)23-16-29-8-3-11-35-23/h4-7,13-14,20,23,29H,3,8-12,16H2,1-2H3,(H,30,33)/t20-,23-/m0/s1 MXLUPQFOOQNBIW-REWPJTCUSA-N 616202 (2S)-N-[(1S)-1-Cyano-2-(4-13-[2-(dimethylamino)ethyl]-2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl}phenyl)ethyl]-1,4-oxazepane-2-carboxamide::US20230278969, Example 13 Dipeptidyl peptidase 1 7.24 US Patent 10.7270/Q24X5CXQ US20230278969 LONN, HR; CONNOLLY, S; SWALLOW, S; KARLSSON, SP; AURELL, C; PONTÉN, JF; DOYLE, KJ; VAN DE POËL, AJ; JONES, GP; WATSON, DW; MACRITCHIE, JA; PALMER, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=616202 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=616202&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1312855 CN1C(=O)C(F)(F)c2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H24F2N4O3/c1-30-20-12-17(7-8-19(20)24(25,26)23(30)32)16-5-3-15(4-6-16)11-18(13-27)29-22(31)21-14-28-9-2-10-33-21/h3-8,12,18,21,28H,2,9-11,14H2,1H3,(H,29,31)/t18-,21-/m0/s1 SABYNPLHFAPZQF-RXVVDRJESA-N 50195242 CHEMBL3917575::US10287258, Example 14::US10669245, Example 14::US11117874, Example 14::US11655221, Example 14::US11680049, Example 14::US20230278969, Example 14 Dipeptidyl peptidase 1 16.6 US Patent 10.7270/Q24X5CXQ US20230278969 LONN, HR; CONNOLLY, S; SWALLOW, S; KARLSSON, SP; AURELL, C; PONTÉN, JF; DOYLE, KJ; VAN DE POËL, AJ; JONES, GP; WATSON, DW; MACRITCHIE, JA; PALMER, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195242&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253811 375977097 CHEMBL3917575 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1312856 Cn1c2cc(cc(F)c2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H23FN4O4/c1-28-19-11-16(10-18(24)21(19)32-23(28)30)15-5-3-14(4-6-15)9-17(12-25)27-22(29)20-13-26-7-2-8-31-20/h3-6,10-11,17,20,26H,2,7-9,13H2,1H3,(H,27,29)/t17-,20-/m0/s1 IVHOZTBKWBUDMJ-PXNSSMCTSA-N 385055 (2S)-N-{(1S)-1-Cyano-2-[4-(7-fluoro-3-methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-5- yl)phenyl]ethyl}-1,4-oxazepane-2-carboxamide::US10287258, Example 15::US10669245, Example 15::US11117874, Example 15::US11655221, Example 15::US11667615, Example 15::US11680049, Example 15::US20230278969, Example 15 Dipeptidyl peptidase 1 5.13 US Patent 10.7270/Q24X5CXQ US20230278969 LONN, HR; CONNOLLY, S; SWALLOW, S; KARLSSON, SP; AURELL, C; PONTÉN, JF; DOYLE, KJ; VAN DE POËL, AJ; JONES, GP; WATSON, DW; MACRITCHIE, JA; PALMER, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385055&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253861 404854278 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1312857 CCn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H26N4O4/c1-2-28-20-13-18(8-9-21(20)32-24(28)30)17-6-4-16(5-7-17)12-19(14-25)27-23(29)22-15-26-10-3-11-31-22/h4-9,13,19,22,26H,2-3,10-12,15H2,1H3,(H,27,29)/t19-,22-/m0/s1 HZZYFVOLMKQYKP-UGKGYDQZSA-N 604854 (2S)-N-{(1S)-1-Cyano-2-[4-(3-ethyl-7-methyl-2-oxo-2,3-dihydro-1,3-benzoxazo1-5-yl)phenyl]ethyl}-1,4-oxazepane-2-carboxamide::US11667615, Example 10::US11667615, Example 16::US11680049, Example 16::US20230278969, Example 16 Dipeptidyl peptidase 1 5.75 US Patent 10.7270/Q24X5CXQ US20230278969 LONN, HR; CONNOLLY, S; SWALLOW, S; KARLSSON, SP; AURELL, C; PONTÉN, JF; DOYLE, KJ; VAN DE POËL, AJ; JONES, GP; WATSON, DW; MACRITCHIE, JA; PALMER, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=604854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=604854&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253883 482597541 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1312858 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2oc(=O)n(CC3CC3)c2c1)C#N)[C@@H]1CNCCCO1 InChI=1S/C26H28N4O4/c27-14-21(29-25(31)24-15-28-10-1-11-33-24)12-17-4-6-19(7-5-17)20-8-9-23-22(13-20)30(26(32)34-23)16-18-2-3-18/h4-9,13,18,21,24,28H,1-3,10-12,15-16H2,(H,29,31)/t21-,24-/m0/s1 WJXGZWWSCFPECN-URXFXBBRSA-N 385057 (2S)-N-[(1S)-1-Cyano-2-{4-[3-(cyclopropylmethyl)-2-oxo-2,3-dihydro-1,3-benzoxazol- 5-yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 17::US10669245, Example 17::US11117874, Example 17::US11655221, Example 17::US11667615, Example 17::US11680049, Example 17::US20230278969, Example 17 Dipeptidyl peptidase 1 6.31 US Patent 10.7270/Q24X5CXQ US20230278969 LONN, HR; CONNOLLY, S; SWALLOW, S; KARLSSON, SP; AURELL, C; PONTÉN, JF; DOYLE, KJ; VAN DE POËL, AJ; JONES, GP; WATSON, DW; MACRITCHIE, JA; PALMER, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385057&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253827 404854280 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1312859 COCCn1c2cc(ccc2sc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C25H28N4O4S/c1-32-12-10-29-21-14-19(7-8-23(21)34-25(29)31)18-5-3-17(4-6-18)13-20(15-26)28-24(30)22-16-27-9-2-11-33-22/h3-8,14,20,22,27H,2,9-13,16H2,1H3,(H,28,30)/t20-,22-/m0/s1 GRJJVLYWMJAVMA-UNMCSNQZSA-N 385058 (2S)-N-[(1S)-1-Cyano-2-{4-[3-(2-methoxyethyl)-2-oxo-2,3-dihydro-1,3-benzothiazol- 5-yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 18::US10669245, Example 18::US11117874, Example 18::US11655221, Example 18::US11667615, Example 18::US11680049, Example 18::US20230278969, Example 18 Dipeptidyl peptidase 1 3.16 US Patent 10.7270/Q24X5CXQ US20230278969 LONN, HR; CONNOLLY, S; SWALLOW, S; KARLSSON, SP; AURELL, C; PONTÉN, JF; DOYLE, KJ; VAN DE POËL, AJ; JONES, GP; WATSON, DW; MACRITCHIE, JA; PALMER, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385058&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253842 404854281 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1312860 CC(C)n1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C25H28N4O4/c1-16(2)29-21-13-19(8-9-22(21)33-25(29)31)18-6-4-17(5-7-18)12-20(14-26)28-24(30)23-15-27-10-3-11-32-23/h4-9,13,16,20,23,27H,3,10-12,15H2,1-2H3,(H,28,30)/t20-,23-/m0/s1 WOBKXJRTDASPHQ-REWPJTCUSA-N 385059 (2S)-N- [(1S)-1-Cyano-2-{4-[2-oxo-3-(propan-2-yl)-2,3-dihydro-1,3-benzoxazol-5- yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 19::US10669245, Example 19::US11117874, Example 19::US11655221, Example 19::US11667615, Example 19::US11680049, Example 19::US20230278969, Example 19 Dipeptidyl peptidase 1 14.5 US Patent 10.7270/Q24X5CXQ US20230278969 LONN, HR; CONNOLLY, S; SWALLOW, S; KARLSSON, SP; AURELL, C; PONTÉN, JF; DOYLE, KJ; VAN DE POËL, AJ; JONES, GP; WATSON, DW; MACRITCHIE, JA; PALMER, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385059&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253878 404854282 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1312861 CN1C(=O)COc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H26N4O4/c1-28-20-12-18(7-8-21(20)32-15-23(28)29)17-5-3-16(4-6-17)11-19(13-25)27-24(30)22-14-26-9-2-10-31-22/h3-8,12,19,22,26H,2,9-11,14-15H2,1H3,(H,27,30)/t19-,22-/m0/s1 QKDQSHLZLZUQOA-UGKGYDQZSA-N 50195238 CHEMBL3962926::US10287258, Example 20::US10669245, Example 20::US11117874, Example 20::US11655221, Example 20::US11680049, Example 20::US20230278969, Example 20 Dipeptidyl peptidase 1 12.6 US Patent 10.7270/Q24X5CXQ US20230278969 LONN, HR; CONNOLLY, S; SWALLOW, S; KARLSSON, SP; AURELL, C; PONTÉN, JF; DOYLE, KJ; VAN DE POËL, AJ; JONES, GP; WATSON, DW; MACRITCHIE, JA; PALMER, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195238 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195238&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253870 375977093 CHEMBL3962926 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1312862 COCCn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C25H28N4O5/c1-32-12-10-29-21-14-19(7-8-22(21)34-25(29)31)18-5-3-17(4-6-18)13-20(15-26)28-24(30)23-16-27-9-2-11-33-23/h3-8,14,20,23,27H,2,9-13,16H2,1H3,(H,28,30)/t20-,23-/m0/s1 JUXOTDAODWSCQS-REWPJTCUSA-N 385061 (2S)-N-[(1S)-1-Cyano-2-{4-[3-(2-methoxyethyl)-2-oxo-2,3-dihydro-1,3-benzoxazol-5- yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 21::US10669245, Example 21::US11117874, Example 21::US11655221, Example 21::US11667615, Example 21::US11680049, Example 21::US20230278969, Example 21 Dipeptidyl peptidase 1 8.13 US Patent 10.7270/Q24X5CXQ US20230278969 LONN, HR; CONNOLLY, S; SWALLOW, S; KARLSSON, SP; AURELL, C; PONTÉN, JF; DOYLE, KJ; VAN DE POËL, AJ; JONES, GP; WATSON, DW; MACRITCHIE, JA; PALMER, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385061&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253879 404854284 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1312863 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(s1)C#N)C#N)[C@@H]1CNCCCO1 InChI=1S/C20H20N4O2S/c21-11-16(24-20(25)18-13-23-8-1-9-26-18)10-14-2-4-15(5-3-14)19-7-6-17(12-22)27-19/h2-7,16,18,23H,1,8-10,13H2,(H,24,25)/t16-,18-/m0/s1 AYKAKRZDQIFHMD-WMZOPIPTSA-N 385062 (2S)-N-{(1S)-1-Cyano-2-[4-(5-cyanothiophen-2-yl)phenyl]ethyl}-1,4-oxazepane-2- carboxamide::US10287258, Example 22::US10669245, Example 22::US11117874, Example 22::US11655221, Example 22::US11667615, Example 22::US11680049, Example 22::US20230278969, Example 22 Dipeptidyl peptidase 1 19.5 US Patent 10.7270/Q24X5CXQ US20230278969 LONN, HR; CONNOLLY, S; SWALLOW, S; KARLSSON, SP; AURELL, C; PONTÉN, JF; DOYLE, KJ; VAN DE POËL, AJ; JONES, GP; WATSON, DW; MACRITCHIE, JA; PALMER, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385062&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253837 404854285 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1312864 NC(=O)c1ccc(cc1F)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C22H23FN4O3/c23-19-11-16(6-7-18(19)21(25)28)15-4-2-14(3-5-15)10-17(12-24)27-22(29)20-13-26-8-1-9-30-20/h2-7,11,17,20,26H,1,8-10,13H2,(H2,25,28)(H,27,29)/t17-,20-/m0/s1 GCGGEFOSHQPZEX-PXNSSMCTSA-N 385063 (2S)-N-[(1S)-2-(4'-Carbamoy1-3'-fluorobiphenyl-4-yl)-1-cyanoethyl]-1,4-oxazepane-2- carboxamide::US10287258, Example 23::US10669245, Example 23::US11117874, Example 23::US11655221, Example 23::US11667615, Example 23::US11680049, Example 23::US20230278969, Example 23 Dipeptidyl peptidase 1 67.6 US Patent 10.7270/Q24X5CXQ US20230278969 LONN, HR; CONNOLLY, S; SWALLOW, S; KARLSSON, SP; AURELL, C; PONTÉN, JF; DOYLE, KJ; VAN DE POËL, AJ; JONES, GP; WATSON, DW; MACRITCHIE, JA; PALMER, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385063&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253894 404854286 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1312865 Cn1c2cc(ccc2ccc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C25H26N4O3/c1-29-22-14-20(8-7-19(22)9-10-24(29)30)18-5-3-17(4-6-18)13-21(15-26)28-25(31)23-16-27-11-2-12-32-23/h3-10,14,21,23,27H,2,11-13,16H2,1H3,(H,28,31)/t21-,23-/m0/s1 BQIZWZAQEICNDG-GMAHTHKFSA-N 50195244 CHEMBL3926554::US10287258, Example 24::US10669245, Example 24::US11117874, Example 24::US11655221, Example 24::US11680049, Example 24::US20230278969, Example 24 Dipeptidyl peptidase 1 13.8 US Patent 10.7270/Q24X5CXQ US20230278969 LONN, HR; CONNOLLY, S; SWALLOW, S; KARLSSON, SP; AURELL, C; PONTÉN, JF; DOYLE, KJ; VAN DE POËL, AJ; JONES, GP; WATSON, DW; MACRITCHIE, JA; PALMER, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195244&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253851 375977099 CHEMBL3926554 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1312866 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2oc(=O)n(CC3CCOCC3)c2c1)C#N)[C@@H]1CNCCCO1 InChI=1S/C28H32N4O5/c29-16-23(31-27(33)26-17-30-10-1-11-36-26)14-19-2-4-21(5-3-19)22-6-7-25-24(15-22)32(28(34)37-25)18-20-8-12-35-13-9-20/h2-7,15,20,23,26,30H,1,8-14,17-18H2,(H,31,33)/t23-,26-/m0/s1 KFOHIWSKADTAQW-OZXSUGGESA-N 385065 (2S)-N-[(1S)-1-Cyano-2-{4-[2-oxo-3-(tetrahydro-2H-pyran-4-ylmethyl)-2,3-dihydro- 1,3-benzoxazol-5-yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 25::US10669245, Example 25::US11117874, Example 25::US11655221, Example 25::US11667615, Example 25::US11680049, Example 25::US20230278969, Example 25 Dipeptidyl peptidase 1 10.7 US Patent 10.7270/Q24X5CXQ US20230278969 LONN, HR; CONNOLLY, S; SWALLOW, S; KARLSSON, SP; AURELL, C; PONTÉN, JF; DOYLE, KJ; VAN DE POËL, AJ; JONES, GP; WATSON, DW; MACRITCHIE, JA; PALMER, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385065&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253876 404854288 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1312867 Cn1c2cc(cc(Cl)c2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H23ClN4O4/c1-28-19-11-16(10-18(24)21(19)32-23(28)30)15-5-3-14(4-6-15)9-17(12-25)27-22(29)20-13-26-7-2-8-31-20/h3-6,10-11,17,20,26H,2,7-9,13H2,1H3,(H,27,29)/t17-,20-/m0/s1 KTGYWWMCWUTXTI-PXNSSMCTSA-N 385066 (2S)-N-{(1S)-2-[4-(7-Chloro-3-methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)phenyl]- 1-cyanoethyl}-1,4-oxazepane-2-carboxamide::US10287258, Example 26::US10669245, Example 26::US11117874, Example 26::US11655221, Example 26::US11667615, Example 26::US11680049, Example 26::US20230278969, Example 26 Dipeptidyl peptidase 1 13.5 US Patent 10.7270/Q24X5CXQ US20230278969 LONN, HR; CONNOLLY, S; SWALLOW, S; KARLSSON, SP; AURELL, C; PONTÉN, JF; DOYLE, KJ; VAN DE POËL, AJ; JONES, GP; WATSON, DW; MACRITCHIE, JA; PALMER, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385066&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253874 404854289 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1312868 FC(F)Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H24F2N4O4/c25-22(26)14-30-19-11-17(6-7-20(19)34-24(30)32)16-4-2-15(3-5-16)10-18(12-27)29-23(31)21-13-28-8-1-9-33-21/h2-7,11,18,21-22,28H,1,8-10,13-14H2,(H,29,31)/t18-,21-/m0/s1 ANPJTTUBCRFBKA-RXVVDRJESA-N 50195248 CHEMBL3891374::US10287258, Example 27::US10669245, Example 27::US11117874, Example 27::US11655221, Example 27::US11680049, Example 27::US20230278969, Example 27 Dipeptidyl peptidase 1 6.61 US Patent 10.7270/Q24X5CXQ US20230278969 LONN, HR; CONNOLLY, S; SWALLOW, S; KARLSSON, SP; AURELL, C; PONTÉN, JF; DOYLE, KJ; VAN DE POËL, AJ; JONES, GP; WATSON, DW; MACRITCHIE, JA; PALMER, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195248 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195248&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253888 375977103 CHEMBL3891374 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1312869 FC(F)(F)Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H23F3N4O4/c25-24(26,27)14-31-19-11-17(6-7-20(19)35-23(31)33)16-4-2-15(3-5-16)10-18(12-28)30-22(32)21-13-29-8-1-9-34-21/h2-7,11,18,21,29H,1,8-10,13-14H2,(H,30,32)/t18-,21-/m0/s1 KAGSLWGZQVTFPB-RXVVDRJESA-N 385068 (2S)-N-[(1S)-1-Cyano-2-{4-[2-oxo-3-(2,2,2-trifluoroethyl)-2,3-dihydro-1,3- benzoxazol-5-yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 28::US10669245, Example 28::US11117874, Example 28::US11655221, Example 28::US11667615, Example 28::US11680049, Example 28::US20230278969, Example 28 Dipeptidyl peptidase 1 8.13 US Patent 10.7270/Q24X5CXQ US20230278969 LONN, HR; CONNOLLY, S; SWALLOW, S; KARLSSON, SP; AURELL, C; PONTÉN, JF; DOYLE, KJ; VAN DE POËL, AJ; JONES, GP; WATSON, DW; MACRITCHIE, JA; PALMER, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385068&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253867 404854291 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1312870 Cn1c2cc(ccc2sc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H24N4O3S/c1-27-19-12-17(7-8-21(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)20-14-25-9-2-10-30-20/h3-8,12,18,20,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,20-/m0/s1 DRQDONWWFWYTII-ICSRJNTNSA-N 50195239 CHEMBL3972563::US10287258, Example 29::US10669245, Example 29::US11117874, Example 29::US11655221, Example 29::US11680049, Example 29::US20230278969, Example 29 Dipeptidyl peptidase 1 2.40 US Patent 10.7270/Q24X5CXQ US20230278969 LONN, HR; CONNOLLY, S; SWALLOW, S; KARLSSON, SP; AURELL, C; PONTÉN, JF; DOYLE, KJ; VAN DE POËL, AJ; JONES, GP; WATSON, DW; MACRITCHIE, JA; PALMER, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195239&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91826235 375977094 CHEMBL3972563 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1312871 CS(=O)(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C22H25N3O4S/c1-30(27,28)20-9-7-18(8-10-20)17-5-3-16(4-6-17)13-19(14-23)25-22(26)21-15-24-11-2-12-29-21/h3-10,19,21,24H,2,11-13,15H2,1H3,(H,25,26)/t19-,21-/m0/s1 UBRDXNDHEGQOTI-FPOVZHCZSA-N 385070 (2S)-N-{(1S)-1-Cyano-2-[4'-(methylsulfonyl)bipheny1-4-yl]ethyl}-1,4-oxazepane-2- carboxamide::US10287258, Example 30::US10669245, Example 30::US11117874, Example 30::US11655221, Example 30::US11667615, Example 30::US11680049, Example 30::US20230278969, Example 30 Dipeptidyl peptidase 1 37.2 US Patent 10.7270/Q24X5CXQ US20230278969 LONN, HR; CONNOLLY, S; SWALLOW, S; KARLSSON, SP; AURELL, C; PONTÉN, JF; DOYLE, KJ; VAN DE POËL, AJ; JONES, GP; WATSON, DW; MACRITCHIE, JA; PALMER, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385070&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253895 404854293 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1312872 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N1CCC1)C#N)[C@@H]1CNCCCO1 InChI=1S/C24H28N4O4S/c25-16-21(27-24(29)23-17-26-11-1-14-32-23)15-18-3-5-19(6-4-18)20-7-9-22(10-8-20)33(30,31)28-12-2-13-28/h3-10,21,23,26H,1-2,11-15,17H2,(H,27,29)/t21-,23-/m0/s1 CBWWXOUBSQCMHB-GMAHTHKFSA-N 385071 (2S)-N-{(1S)-2-[4'-(Azetidin-1-ylsulfonyl)biphenyl-4-yl]-1-cyanoethyl}-1,4-oxazepane- 2-carboxamide::US10287258, Example 31::US10669245, Example 31::US11117874, Example 31::US11655221, Example 31::US11667615, Example 31::US11680049, Example 31::US20230278969, Example 31 Dipeptidyl peptidase 1 21.4 US Patent 10.7270/Q24X5CXQ US20230278969 LONN, HR; CONNOLLY, S; SWALLOW, S; KARLSSON, SP; AURELL, C; PONTÉN, JF; DOYLE, KJ; VAN DE POËL, AJ; JONES, GP; WATSON, DW; MACRITCHIE, JA; PALMER, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385071&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253890 404854294 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1312873 Fc1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C21H22FN3O2/c22-18-8-6-17(7-9-18)16-4-2-15(3-5-16)12-19(13-23)25-21(26)20-14-24-10-1-11-27-20/h2-9,19-20,24H,1,10-12,14H2,(H,25,26)/t19-,20-/m0/s1 PYXGGJVWIVBQRO-PMACEKPBSA-N 385072 (2S)-N-[(1S)-1-Cyano-2-(4'-fluorobiphenyl-4-yl)ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 32::US10669245, Example 32::US11117874, Example 32::US11655221, Example 32::US11667615, Example 32::US11680049, Example 32::US20230278969, Example 32 Dipeptidyl peptidase 1 42.7 US Patent 10.7270/Q24X5CXQ US20230278969 LONN, HR; CONNOLLY, S; SWALLOW, S; KARLSSON, SP; AURELL, C; PONTÉN, JF; DOYLE, KJ; VAN DE POËL, AJ; JONES, GP; WATSON, DW; MACRITCHIE, JA; PALMER, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385072&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253858 404854295 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1312874 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2scnc2c1)C#N)[C@@H]1CNCCCO1 InChI=1S/C22H22N4O2S/c23-12-18(26-22(27)20-13-24-8-1-9-28-20)10-15-2-4-16(5-3-15)17-6-7-21-19(11-17)25-14-29-21/h2-7,11,14,18,20,24H,1,8-10,13H2,(H,26,27)/t18-,20-/m0/s1 MUTKXUKCDAFWLB-ICSRJNTNSA-N 50195263 CHEMBL3942969::US10287258, Example 33::US10669245, Example 33::US11117874, Example 33::US11673871, Example 33::US11680049, Example 33::US20230278969, Example 33 Dipeptidyl peptidase 1 61.7 US Patent 10.7270/Q24X5CXQ US20230278969 LONN, HR; CONNOLLY, S; SWALLOW, S; KARLSSON, SP; AURELL, C; PONTÉN, JF; DOYLE, KJ; VAN DE POËL, AJ; JONES, GP; WATSON, DW; MACRITCHIE, JA; PALMER, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195263&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253877 375977118 CHEMBL3942969 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1312875 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)C1CNCCCO1 InChI=1S/C22H22N4O2/c23-13-17-4-8-19(9-5-17)18-6-2-16(3-7-18)12-20(14-24)26-22(27)21-15-25-10-1-11-28-21/h2-9,20-21,25H,1,10-12,15H2,(H,26,27)/t20-,21?/m0/s1 FCRODBUNBQJNPU-BGERDNNASA-N 50195262 CHEMBL3966946::US11655221, Example 34::US20230278969, Example 34 Dipeptidyl peptidase 1 60.3 US Patent 10.7270/Q24X5CXQ US20230278969 LONN, HR; CONNOLLY, S; SWALLOW, S; KARLSSON, SP; AURELL, C; PONTÉN, JF; DOYLE, KJ; VAN DE POËL, AJ; JONES, GP; WATSON, DW; MACRITCHIE, JA; PALMER, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195262 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195262&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118260121 375977117 CHEMBL3966946 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1312876 CN1C(=O)CNc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H27N5O3/c1-29-21-12-18(7-8-20(21)27-15-23(29)30)17-5-3-16(4-6-17)11-19(13-25)28-24(31)22-14-26-9-2-10-32-22/h3-8,12,19,22,26-27H,2,9-11,14-15H2,1H3,(H,28,31)/t19-,22-/m0/s1 CPBDCTBYFQTDMV-UGKGYDQZSA-N 385075 US10287258, Example 35::US10669245, Example 35::US11117874, Example 35::US11673871, Example 35::US11680049, Example 35::US20230278969, Example 35 Dipeptidyl peptidase 1 24.5 US Patent 10.7270/Q24X5CXQ US20230278969 LONN, HR; CONNOLLY, S; SWALLOW, S; KARLSSON, SP; AURELL, C; PONTÉN, JF; DOYLE, KJ; VAN DE POËL, AJ; JONES, GP; WATSON, DW; MACRITCHIE, JA; PALMER, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385075&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253822 404854298 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1312877 CC[C@H](NC(=O)[C@@H]1CNCCCO1)\C=C\C(=O)N1CCc2ccccc12 InChI=1S/C20H27N3O3/c1-2-16(22-20(25)18-14-21-11-5-13-26-18)8-9-19(24)23-12-10-15-6-3-4-7-17(15)23/h3-4,6-9,16,18,21H,2,5,10-14H2,1H3,(H,22,25)/b9-8+/t16-,18-/m0/s1 OHNHQTNQBQMALV-LFGVRAQPSA-N 385076 BDBM445984::US10287258, Example 36::US11667615, Example 36::US11680049, Example 36::US20230278969, Example 36 Dipeptidyl peptidase 1 5.01 US Patent 10.7270/Q24X5CXQ US20230278969 LONN, HR; CONNOLLY, S; SWALLOW, S; KARLSSON, SP; AURELL, C; PONTÉN, JF; DOYLE, KJ; VAN DE POËL, AJ; JONES, GP; WATSON, DW; MACRITCHIE, JA; PALMER, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385076&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 144891673 404854299 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1312878 CC(C)C[C@H](NC(=O)[C@@H]1CNCCCO1)\C=C\C(=O)N1CCc2ccccc12 InChI=1S/C22H31N3O3/c1-16(2)14-18(24-22(27)20-15-23-11-5-13-28-20)8-9-21(26)25-12-10-17-6-3-4-7-19(17)25/h3-4,6-9,16,18,20,23H,5,10-15H2,1-2H3,(H,24,27)/b9-8+/t18-,20+/m1/s1 PXFMGAFAIVURSO-ZZHWGSSASA-N 385077 BDBM445985::US10287258, Example 37::US11667615, Example 37::US11680049, Example 37::US20230278969, Example 37 Dipeptidyl peptidase 1 5.25 US Patent 10.7270/Q24X5CXQ US20230278969 LONN, HR; CONNOLLY, S; SWALLOW, S; KARLSSON, SP; AURELL, C; PONTÉN, JF; DOYLE, KJ; VAN DE POËL, AJ; JONES, GP; WATSON, DW; MACRITCHIE, JA; PALMER, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385077&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 144891689 404854300 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1312844 Cc1cc(cc2n(C)c(=O)oc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H26N4O4/c1-15-10-18(12-20-22(15)32-24(30)28(20)2)17-6-4-16(5-7-17)11-19(13-25)27-23(29)21-14-26-8-3-9-31-21/h4-7,10,12,19,21,26H,3,8-9,11,14H2,1-2H3,(H,27,29)/t19-,21-/m0/s1 WCWJGAFMGPMBQG-FPOVZHCZSA-N 50195240 CHEMBL3960432::US10287258, Example 3::US10669245, Example 3::US11117874, Example 3::US11655221, Example 3::US11680049, Example 3::US20230278969, Example 3 Dipeptidyl peptidase 1 10.2 US Patent 10.7270/Q24X5CXQ US20230278969 LONN, HR; CONNOLLY, S; SWALLOW, S; KARLSSON, SP; AURELL, C; PONTÉN, JF; DOYLE, KJ; VAN DE POËL, AJ; JONES, GP; WATSON, DW; MACRITCHIE, JA; PALMER, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195240&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253824 375977095 CHEMBL3960432 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1312842 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)[C@@H]1CNCCCO1 InChI=1S/C22H22N4O2/c23-13-17-4-8-19(9-5-17)18-6-2-16(3-7-18)12-20(14-24)26-22(27)21-15-25-10-1-11-28-21/h2-9,20-21,25H,1,10-12,15H2,(H,26,27)/t20-,21-/m0/s1 FCRODBUNBQJNPU-SFTDATJTSA-N 50195236 CHEMBL3927609::US10287258, Example 1::US10669245, Example 1::US11117874, Example 1::US11673871, Example 34::US11680049, Example 1::US20230278969, Example 1 Dipeptidyl peptidase 1 35.5 US Patent 10.7270/Q24X5CXQ US20230278969 LONN, HR; CONNOLLY, S; SWALLOW, S; KARLSSON, SP; AURELL, C; PONTÉN, JF; DOYLE, KJ; VAN DE POËL, AJ; JONES, GP; WATSON, DW; MACRITCHIE, JA; PALMER, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195236&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253857 375977091 CHEMBL3927609 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1312843 Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H24N4O4/c1-27-19-12-17(7-8-20(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)21-14-25-9-2-10-30-21/h3-8,12,18,21,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,21-/m0/s1 AEXFXNFMSAAELR-RXVVDRJESA-N 50195235 CHEMBL3900409::US10287258, Example 2::US10669245, Example 2::US11117874, Example 2::US11655221, Example 2::US11680049, Example 2::US20230278969, Example 2 Dipeptidyl peptidase 1 4.47 US Patent 10.7270/Q24X5CXQ US20230278969 LONN, HR; CONNOLLY, S; SWALLOW, S; KARLSSON, SP; AURELL, C; PONTÉN, JF; DOYLE, KJ; VAN DE POËL, AJ; JONES, GP; WATSON, DW; MACRITCHIE, JA; PALMER, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195235&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253852 375977090 CHEMBL3900409 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1312845 CS(=O)(=O)Oc1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C22H25N3O5S/c1-31(27,28)30-20-5-2-4-18(13-20)17-8-6-16(7-9-17)12-19(14-23)25-22(26)21-15-24-10-3-11-29-21/h2,4-9,13,19,21,24H,3,10-12,15H2,1H3,(H,25,26)/t19-,21-/m0/s1 IRYUDRJLDSHZAO-FPOVZHCZSA-N 385044 4′-[(2S)-2-Cyano-2-{[(2S)-1,4-oxazepan-2-ylcarbonyl]amino}ethyl]biphenyl-3-yl methanesulfonate::US10287258, Example 4::US10669245, Example 4::US11117874, Example 4::US11667615, Example 4::US11680049, Example 4::US20230278969, Example 4 Dipeptidyl peptidase 1 79.4 US Patent 10.7270/Q24X5CXQ US20230278969 LONN, HR; CONNOLLY, S; SWALLOW, S; KARLSSON, SP; AURELL, C; PONTÉN, JF; DOYLE, KJ; VAN DE POËL, AJ; JONES, GP; WATSON, DW; MACRITCHIE, JA; PALMER, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385044&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253891 404854267 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1312846 Cc1noc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H24N4O3/c1-15-20-12-18(7-8-21(20)30-27-15)17-5-3-16(4-6-17)11-19(13-24)26-23(28)22-14-25-9-2-10-29-22/h3-8,12,19,22,25H,2,9-11,14H2,1H3,(H,26,28)/t19-,22-/m0/s1 QCTYSVBOKIUUFU-UGKGYDQZSA-N 50195245 CHEMBL3972158::US10287258, Example 5::US10669245, Example 5::US11117874, Example 5::US11655221, Example 5::US11680049, Example 5::US20230278969, Example 5 Dipeptidyl peptidase 1 16.2 US Patent 10.7270/Q24X5CXQ US20230278969 LONN, HR; CONNOLLY, S; SWALLOW, S; KARLSSON, SP; AURELL, C; PONTÉN, JF; DOYLE, KJ; VAN DE POËL, AJ; JONES, GP; WATSON, DW; MACRITCHIE, JA; PALMER, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195245 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195245&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253855 375977100 CHEMBL3972158 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1312847 FC(F)(F)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C22H22F3N3O2/c23-22(24,25)18-8-6-17(7-9-18)16-4-2-15(3-5-16)12-19(13-26)28-21(29)20-14-27-10-1-11-30-20/h2-9,19-20,27H,1,10-12,14H2,(H,28,29)/t19-,20-/m0/s1 USBDHHJQNTYSNJ-PMACEKPBSA-N 50195255 CHEMBL3945475::US10287258, Example 6::US10669245, Example 6::US11117874, Example 6::US11655221, Example 6::US11680049, Example 6::US20230278969, Example 6 Dipeptidyl peptidase 1 36.3 US Patent 10.7270/Q24X5CXQ US20230278969 LONN, HR; CONNOLLY, S; SWALLOW, S; KARLSSON, SP; AURELL, C; PONTÉN, JF; DOYLE, KJ; VAN DE POËL, AJ; JONES, GP; WATSON, DW; MACRITCHIE, JA; PALMER, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195255 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195255&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253859 375977110 CHEMBL3945475 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1312848 Fc1ccc(cc1F)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C21H21F2N3O2/c22-18-7-6-16(11-19(18)23)15-4-2-14(3-5-15)10-17(12-24)26-21(27)20-13-25-8-1-9-28-20/h2-7,11,17,20,25H,1,8-10,13H2,(H,26,27)/t17-,20-/m0/s1 HSWVIXGRFREZJG-PXNSSMCTSA-N 385047 (2S)-N-[(1S)-1-Cyano-2-(3',4'-difluorobiphenyl-4-yl)ethyl]-1,4-oxazepane-2- carboxamide::US10287258, Example 7::US10669245, Example 7::US11117874, Example 7::US11655221, Example 7::US11667615, Example 7::US11680049, Example 7::US20230278969, Example 7 Dipeptidyl peptidase 1 69.2 US Patent 10.7270/Q24X5CXQ US20230278969 LONN, HR; CONNOLLY, S; SWALLOW, S; KARLSSON, SP; AURELL, C; PONTÉN, JF; DOYLE, KJ; VAN DE POËL, AJ; JONES, GP; WATSON, DW; MACRITCHIE, JA; PALMER, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385047&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253829 404854270 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1312849 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(nc1)C#N)C#N)[C@@H]1CNCCCO1 InChI=1S/C21H21N5O2/c22-11-18-7-6-17(13-25-18)16-4-2-15(3-5-16)10-19(12-23)26-21(27)20-14-24-8-1-9-28-20/h2-7,13,19-20,24H,1,8-10,14H2,(H,26,27)/t19-,20-/m0/s1 UZXVZQQAOVNOKG-PMACEKPBSA-N 385048 (2S)-N-{(1S)-1-Cyano-2-[4-(6-cyanopyridin-3-yl)phenyl]ethyl}-1,4-oxazepane-2- carboxamide::US10287258, Example 8::US10669245, Example 8::US11117874, Example 8::US11655221, Example 8::US11667615, Example 8::US11680049, Example 8::US20230278969, Example 8 Dipeptidyl peptidase 1 87.1 US Patent 10.7270/Q24X5CXQ US20230278969 LONN, HR; CONNOLLY, S; SWALLOW, S; KARLSSON, SP; AURELL, C; PONTÉN, JF; DOYLE, KJ; VAN DE POËL, AJ; JONES, GP; WATSON, DW; MACRITCHIE, JA; PALMER, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385048&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253853 404854271 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1312850 CN1C(=O)CSc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H26N4O3S/c1-28-20-12-18(7-8-22(20)32-15-23(28)29)17-5-3-16(4-6-17)11-19(13-25)27-24(30)21-14-26-9-2-10-31-21/h3-8,12,19,21,26H,2,9-11,14-15H2,1H3,(H,27,30)/t19-,21-/m0/s1 NSLGCWMFHWURGT-FPOVZHCZSA-N 385049 (2S)-N-{(1S)-1-Cyano-2-[4-(4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzothiazin-6- yl)phenyl]ethyl}-1,4-oxazepane-2-carboxamide::US10287258, Example 9::US10669245, Example 9::US11117874, Example 9::US11655221, Example 9::US11667615, Example 9::US11680049, Example 9::US20230278969, Example 9 Dipeptidyl peptidase 1 12.9 US Patent 10.7270/Q24X5CXQ US20230278969 LONN, HR; CONNOLLY, S; SWALLOW, S; KARLSSON, SP; AURELL, C; PONTÉN, JF; DOYLE, KJ; VAN DE POËL, AJ; JONES, GP; WATSON, DW; MACRITCHIE, JA; PALMER, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385049&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253849 404854272 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1312851 CCn1c2cc(cc(C)c2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C25H28N4O4/c1-3-29-21-13-19(11-16(2)23(21)33-25(29)31)18-7-5-17(6-8-18)12-20(14-26)28-24(30)22-15-27-9-4-10-32-22/h5-8,11,13,20,22,27H,3-4,9-10,12,15H2,1-2H3,(H,28,30)/t20-,22-/m0/s1 ORHUZDNZRYZSJO-UNMCSNQZSA-N 385050 (2S)-N-{(1S)-1-Cyano-2-[4-(3-ethyl-7-methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-5- yl)phenyl]ethyl}-1,4-oxazepane-2-carboxamide::US10287258, Example 10::US10669245, Example 10::US11117874, Example 10::US11655221, Example 10::US11680049, Example 10::US20230278969, Example 10 Dipeptidyl peptidase 1 21.4 US Patent 10.7270/Q24X5CXQ US20230278969 LONN, HR; CONNOLLY, S; SWALLOW, S; KARLSSON, SP; AURELL, C; PONTÉN, JF; DOYLE, KJ; VAN DE POËL, AJ; JONES, GP; WATSON, DW; MACRITCHIE, JA; PALMER, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385050&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253835 404854273 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1312852 CC(C)(O)Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C26H30N4O5/c1-26(2,33)16-30-21-13-19(8-9-22(21)35-25(30)32)18-6-4-17(5-7-18)12-20(14-27)29-24(31)23-15-28-10-3-11-34-23/h4-9,13,20,23,28,33H,3,10-12,15-16H2,1-2H3,(H,29,31)/t20-,23-/m0/s1 LRDOUIXCGZNESR-REWPJTCUSA-N 385051 (2S)-N-[(1S)-1-Cyano-2-{4-[3-(2-hydroxy-2-methylpropyl)-2-oxo-2,3-dihydro-1,3- benzoxazol-5-yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 11::US10669245, Example 11::US11117874, Example 11::US11655221, Example 11::US11667615, Example 11::US11680049, Example 11::US20230278969, Example 11 Dipeptidyl peptidase 1 89.1 US Patent 10.7270/Q24X5CXQ US20230278969 LONN, HR; CONNOLLY, S; SWALLOW, S; KARLSSON, SP; AURELL, C; PONTÉN, JF; DOYLE, KJ; VAN DE POËL, AJ; JONES, GP; WATSON, DW; MACRITCHIE, JA; PALMER, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385051&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253819 404854274 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51406521 NC1(CCOCC1)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N InChI=1S/C22H22N4O2/c23-14-17-3-7-19(8-4-17)18-5-1-16(2-6-18)13-20(15-24)26-21(27)22(25)9-11-28-12-10-22/h1-8,20H,9-13,25H2,(H,26,27)/t20-/m0/s1 NNUFRZJZOXVZIT-FQEVSTJZSA-N 50011502 CHEMBL3261926 Dipeptidyl peptidase 1 1.000000 ChEMBL 10.1016/j.bmcl.2021.128202 10.7270/Q2PR80R9 34139325 Banerjee, A; Velagaleti, R; Patil, S; Pawar, M; Yadav, P; Kadam, P; Qadri, MM; Chakraborti, S; Saini, JS; Behera, DB; Karanjai, K; Iyer, PS; Gharat, LA; Das, S Glenmark Research Centre http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50011502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50011502&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 49783666 103924055 CHEMBL3261926 ZINC36271864 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51406522 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)[C@@H]1COCCN1 InChI=1S/C21H20N4O2/c22-12-16-3-7-18(8-4-16)17-5-1-15(2-6-17)11-19(13-23)25-21(26)20-14-27-10-9-24-20/h1-8,19-20,24H,9-11,14H2,(H,25,26)/t19-,20-/m0/s1 CGYMVFKSSDCCLP-PMACEKPBSA-N 50568306 CHEMBL4846681 Dipeptidyl peptidase 1 308 ChEMBL 10.1016/j.bmcl.2021.128202 10.7270/Q2PR80R9 34139325 Banerjee, A; Velagaleti, R; Patil, S; Pawar, M; Yadav, P; Kadam, P; Qadri, MM; Chakraborti, S; Saini, JS; Behera, DB; Karanjai, K; Iyer, PS; Gharat, LA; Das, S Glenmark Research Centre http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568306 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568306&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 164608929 471058451 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51406523 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)[C@H]1CN2CCC[C@H]2CN1 InChI=1S/C24H25N5O/c25-13-18-5-9-20(10-6-18)19-7-3-17(4-8-19)12-21(14-26)28-24(30)23-16-29-11-1-2-22(29)15-27-23/h3-10,21-23,27H,1-2,11-12,15-16H2,(H,28,30)/t21-,22-,23+/m0/s1 BQWJEMPWVHELPK-RJGXRXQPSA-N 50568307 CHEMBL4847757 Dipeptidyl peptidase 1 394 ChEMBL 10.1016/j.bmcl.2021.128202 10.7270/Q2PR80R9 34139325 Banerjee, A; Velagaleti, R; Patil, S; Pawar, M; Yadav, P; Kadam, P; Qadri, MM; Chakraborti, S; Saini, JS; Behera, DB; Karanjai, K; Iyer, PS; Gharat, LA; Das, S Glenmark Research Centre http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568307 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568307&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 164614875 471058452 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51406524 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)[C@@H]1CCCN1 InChI=1S/C21H20N4O/c22-13-16-5-9-18(10-6-16)17-7-3-15(4-8-17)12-19(14-23)25-21(26)20-2-1-11-24-20/h3-10,19-20,24H,1-2,11-12H2,(H,25,26)/t19-,20-/m0/s1 DCGIOYVBHXSQMR-PMACEKPBSA-N 50502617 CHEMBL4570759 Dipeptidyl peptidase 1 92 ChEMBL 10.1016/j.bmcl.2021.128202 10.7270/Q2PR80R9 34139325 Banerjee, A; Velagaleti, R; Patil, S; Pawar, M; Yadav, P; Kadam, P; Qadri, MM; Chakraborti, S; Saini, JS; Behera, DB; Karanjai, K; Iyer, PS; Gharat, LA; Das, S Glenmark Research Centre http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50502617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50502617&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 155561515 440711202 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51406525 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)[C@@H]1CC2(CC2)CN1 InChI=1S/C23H22N4O/c24-13-17-3-7-19(8-4-17)18-5-1-16(2-6-18)11-20(14-25)27-22(28)21-12-23(9-10-23)15-26-21/h1-8,20-21,26H,9-12,15H2,(H,27,28)/t20-,21-/m0/s1 FHGSPHVULTWIAL-SFTDATJTSA-N 50568308 CHEMBL4851884 Dipeptidyl peptidase 1 78 ChEMBL 10.1016/j.bmcl.2021.128202 10.7270/Q2PR80R9 34139325 Banerjee, A; Velagaleti, R; Patil, S; Pawar, M; Yadav, P; Kadam, P; Qadri, MM; Chakraborti, S; Saini, JS; Behera, DB; Karanjai, K; Iyer, PS; Gharat, LA; Das, S Glenmark Research Centre http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568308 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568308&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 164617870 471058453 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51406526 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)[C@@H]1CC2(CCC2)CN1 InChI=1S/C24H24N4O/c25-14-18-4-8-20(9-5-18)19-6-2-17(3-7-19)12-21(15-26)28-23(29)22-13-24(16-27-22)10-1-11-24/h2-9,21-22,27H,1,10-13,16H2,(H,28,29)/t21-,22-/m0/s1 ZLCLFCKFQSXRSX-VXKWHMMOSA-N 50568309 CHEMBL4864151 Dipeptidyl peptidase 1 28 ChEMBL 10.1016/j.bmcl.2021.128202 10.7270/Q2PR80R9 34139325 Banerjee, A; Velagaleti, R; Patil, S; Pawar, M; Yadav, P; Kadam, P; Qadri, MM; Chakraborti, S; Saini, JS; Behera, DB; Karanjai, K; Iyer, PS; Gharat, LA; Das, S Glenmark Research Centre http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568309&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 164624505 471058454 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51406527 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)[C@@H]1CC2(CCCC2)CN1 InChI=1S/C25H26N4O/c26-15-19-5-9-21(10-6-19)20-7-3-18(4-8-20)13-22(16-27)29-24(30)23-14-25(17-28-23)11-1-2-12-25/h3-10,22-23,28H,1-2,11-14,17H2,(H,29,30)/t22-,23-/m0/s1 OVGNUQWZCUMSOX-GOTSBHOMSA-N 50568310 CHEMBL4875554 Dipeptidyl peptidase 1 10 ChEMBL 10.1016/j.bmcl.2021.128202 10.7270/Q2PR80R9 34139325 Banerjee, A; Velagaleti, R; Patil, S; Pawar, M; Yadav, P; Kadam, P; Qadri, MM; Chakraborti, S; Saini, JS; Behera, DB; Karanjai, K; Iyer, PS; Gharat, LA; Das, S Glenmark Research Centre http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568310 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568310&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 164629084 471058455 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51406528 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)[C@@H]1CC2(CN1)CCCCC2 InChI=1S/C26H28N4O/c27-16-20-6-10-22(11-7-20)21-8-4-19(5-9-21)14-23(17-28)30-25(31)24-15-26(18-29-24)12-2-1-3-13-26/h4-11,23-24,29H,1-3,12-15,18H2,(H,30,31)/t23-,24-/m0/s1 JHTORZALYOXAIJ-ZEQRLZLVSA-N 50568311 CHEMBL4849657 Dipeptidyl peptidase 1 228 ChEMBL 10.1016/j.bmcl.2021.128202 10.7270/Q2PR80R9 34139325 Banerjee, A; Velagaleti, R; Patil, S; Pawar, M; Yadav, P; Kadam, P; Qadri, MM; Chakraborti, S; Saini, JS; Behera, DB; Karanjai, K; Iyer, PS; Gharat, LA; Das, S Glenmark Research Centre http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568311 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568311&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 164610547 471058456 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51406529 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)[C@@H]1C[C@@H]2C[C@@H]2N1 InChI=1S/C22H20N4O/c23-12-15-3-7-17(8-4-15)16-5-1-14(2-6-16)9-19(13-24)25-22(27)21-11-18-10-20(18)26-21/h1-8,18-21,26H,9-11H2,(H,25,27)/t18-,19-,20-,21-/m0/s1 YGNXAEODOHMWOX-TUFLPTIASA-N 50568312 CHEMBL4848266 Dipeptidyl peptidase 1 223 ChEMBL 10.1016/j.bmcl.2021.128202 10.7270/Q2PR80R9 34139325 Banerjee, A; Velagaleti, R; Patil, S; Pawar, M; Yadav, P; Kadam, P; Qadri, MM; Chakraborti, S; Saini, JS; Behera, DB; Karanjai, K; Iyer, PS; Gharat, LA; Das, S Glenmark Research Centre http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568312 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568312&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 164617728 471058457 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51406530 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)[C@@H]1C[C@H]2CCC[C@H]2N1 InChI=1S/C24H24N4O/c25-14-17-6-10-19(11-7-17)18-8-4-16(5-9-18)12-21(15-26)27-24(29)23-13-20-2-1-3-22(20)28-23/h4-11,20-23,28H,1-3,12-13H2,(H,27,29)/t20-,21+,22-,23+/m1/s1 IXUTYJAXGFAXCL-ACESQOTJSA-N 50568313 CHEMBL4854705 Dipeptidyl peptidase 1 78 ChEMBL 10.1016/j.bmcl.2021.128202 10.7270/Q2PR80R9 34139325 Banerjee, A; Velagaleti, R; Patil, S; Pawar, M; Yadav, P; Kadam, P; Qadri, MM; Chakraborti, S; Saini, JS; Behera, DB; Karanjai, K; Iyer, PS; Gharat, LA; Das, S Glenmark Research Centre http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568313 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568313&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 164611822 471058458 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51406531 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)[C@@H]1C[C@@H]2CCC[C@@H]2N1 InChI=1S/C24H24N4O/c25-14-17-6-10-19(11-7-17)18-8-4-16(5-9-18)12-21(15-26)27-24(29)23-13-20-2-1-3-22(20)28-23/h4-11,20-23,28H,1-3,12-13H2,(H,27,29)/t20-,21-,22-,23-/m0/s1 IXUTYJAXGFAXCL-MLCQCVOFSA-N 50568314 CHEMBL4856217 Dipeptidyl peptidase 1 9.3 ChEMBL 10.1016/j.bmcl.2021.128202 10.7270/Q2PR80R9 34139325 Banerjee, A; Velagaleti, R; Patil, S; Pawar, M; Yadav, P; Kadam, P; Qadri, MM; Chakraborti, S; Saini, JS; Behera, DB; Karanjai, K; Iyer, PS; Gharat, LA; Das, S Glenmark Research Centre http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568314 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568314&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 164610837 471058459 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51406532 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)[C@@H]1C[C@@H]2CCCC[C@@H]2N1 InChI=1S/C25H26N4O/c26-15-18-7-11-20(12-8-18)19-9-5-17(6-10-19)13-22(16-27)28-25(30)24-14-21-3-1-2-4-23(21)29-24/h5-12,21-24,29H,1-4,13-14H2,(H,28,30)/t21-,22-,23-,24-/m0/s1 YWDTXSLPEZCSQO-ZJZGAYNASA-N 50568315 CHEMBL4876996 Dipeptidyl peptidase 1 154 ChEMBL 10.1016/j.bmcl.2021.128202 10.7270/Q2PR80R9 34139325 Banerjee, A; Velagaleti, R; Patil, S; Pawar, M; Yadav, P; Kadam, P; Qadri, MM; Chakraborti, S; Saini, JS; Behera, DB; Karanjai, K; Iyer, PS; Gharat, LA; Das, S Glenmark Research Centre http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568315 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568315&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 164627050 471058460 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51406533 CS(=O)(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@@H]2C[C@@H]3CCCC[C@@H]3N2)C#N)cc1 InChI=1S/C25H29N3O3S/c1-32(30,31)22-12-10-19(11-13-22)18-8-6-17(7-9-18)14-21(16-26)27-25(29)24-15-20-4-2-3-5-23(20)28-24/h6-13,20-21,23-24,28H,2-5,14-15H2,1H3,(H,27,29)/t20-,21-,23-,24-/m0/s1 VEGDZMXJLMWSQS-WMIMKTLMSA-N 50568316 CHEMBL4869840 Dipeptidyl peptidase 1 44 ChEMBL 10.1016/j.bmcl.2021.128202 10.7270/Q2PR80R9 34139325 Banerjee, A; Velagaleti, R; Patil, S; Pawar, M; Yadav, P; Kadam, P; Qadri, MM; Chakraborti, S; Saini, JS; Behera, DB; Karanjai, K; Iyer, PS; Gharat, LA; Das, S Glenmark Research Centre http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568316 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568316&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 164625193 471058461 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51406534 CS(=O)(=O)c1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@@H]2C[C@@H]3CCCC[C@@H]3N2)C#N)cc1 InChI=1S/C25H29N3O3S/c1-32(30,31)22-7-4-6-19(14-22)18-11-9-17(10-12-18)13-21(16-26)27-25(29)24-15-20-5-2-3-8-23(20)28-24/h4,6-7,9-12,14,20-21,23-24,28H,2-3,5,8,13,15H2,1H3,(H,27,29)/t20-,21-,23-,24-/m0/s1 YSAQZLTXJUINGY-WMIMKTLMSA-N 50568317 CHEMBL4865824 Dipeptidyl peptidase 1 4.6 ChEMBL 10.1016/j.bmcl.2021.128202 10.7270/Q2PR80R9 34139325 Banerjee, A; Velagaleti, R; Patil, S; Pawar, M; Yadav, P; Kadam, P; Qadri, MM; Chakraborti, S; Saini, JS; Behera, DB; Karanjai, K; Iyer, PS; Gharat, LA; Das, S Glenmark Research Centre http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568317 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568317&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 164625571 471058462 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51406535 CS(=O)(=O)c1cc(ccc1C#N)-c1ccc(C[C@H](NC(=O)[C@@H]2C[C@@H]3CCCC[C@@H]3N2)C#N)cc1 InChI=1S/C26H28N4O3S/c1-34(32,33)25-14-19(10-11-21(25)15-27)18-8-6-17(7-9-18)12-22(16-28)29-26(31)24-13-20-4-2-3-5-23(20)30-24/h6-11,14,20,22-24,30H,2-5,12-13H2,1H3,(H,29,31)/t20-,22-,23-,24-/m0/s1 XWBGCRSWFMZQTD-BIHRQFPBSA-N 50568318 CHEMBL4850769 Dipeptidyl peptidase 1 15 ChEMBL 10.1016/j.bmcl.2021.128202 10.7270/Q2PR80R9 34139325 Banerjee, A; Velagaleti, R; Patil, S; Pawar, M; Yadav, P; Kadam, P; Qadri, MM; Chakraborti, S; Saini, JS; Behera, DB; Karanjai, K; Iyer, PS; Gharat, LA; Das, S Glenmark Research Centre http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568318 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568318&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 164612183 471058463 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51406536 CS(=O)(=O)c1ccc(cc1C#N)-c1ccc(C[C@H](NC(=O)[C@@H]2C[C@@H]3CCCC[C@@H]3N2)C#N)cc1 InChI=1S/C26H28N4O3S/c1-34(32,33)25-11-10-19(13-21(25)15-27)18-8-6-17(7-9-18)12-22(16-28)29-26(31)24-14-20-4-2-3-5-23(20)30-24/h6-11,13,20,22-24,30H,2-5,12,14H2,1H3,(H,29,31)/t20-,22-,23-,24-/m0/s1 JEVLWAWEIDQJSG-BIHRQFPBSA-N 50568319 CHEMBL4869673 Dipeptidyl peptidase 1 6.5 ChEMBL 10.1016/j.bmcl.2021.128202 10.7270/Q2PR80R9 34139325 Banerjee, A; Velagaleti, R; Patil, S; Pawar, M; Yadav, P; Kadam, P; Qadri, MM; Chakraborti, S; Saini, JS; Behera, DB; Karanjai, K; Iyer, PS; Gharat, LA; Das, S Glenmark Research Centre http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568319 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568319&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 164625189 471058464 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51406537 Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2C[C@@H]3CCCC[C@@H]3N2)C#N)cc1 InChI=1S/C26H28N4O3/c1-30-23-14-18(10-11-24(23)33-26(30)32)17-8-6-16(7-9-17)12-20(15-27)28-25(31)22-13-19-4-2-3-5-21(19)29-22/h6-11,14,19-22,29H,2-5,12-13H2,1H3,(H,28,31)/t19-,20-,21-,22-/m0/s1 DLVKZTSJPKNQKL-CMOCDZPBSA-N 50568320 CHEMBL4860749 Dipeptidyl peptidase 1 1248 ChEMBL 10.1016/j.bmcl.2021.128202 10.7270/Q2PR80R9 34139325 Banerjee, A; Velagaleti, R; Patil, S; Pawar, M; Yadav, P; Kadam, P; Qadri, MM; Chakraborti, S; Saini, JS; Behera, DB; Karanjai, K; Iyer, PS; Gharat, LA; Das, S Glenmark Research Centre http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568320 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568320&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 164614348 471058465 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51406538 NC1(CCOCC1)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N InChI=1S/C22H22N4O2/c23-14-17-3-7-19(8-4-17)18-5-1-16(2-6-18)13-20(15-24)26-21(27)22(25)9-11-28-12-10-22/h1-8,20H,9-13,25H2,(H,26,27)/t20-/m0/s1 NNUFRZJZOXVZIT-FQEVSTJZSA-N 50011502 CHEMBL3261926 Dipeptidyl peptidase 1 5.0 ChEMBL 10.1016/j.bmcl.2021.128202 10.7270/Q2PR80R9 34139325 Banerjee, A; Velagaleti, R; Patil, S; Pawar, M; Yadav, P; Kadam, P; Qadri, MM; Chakraborti, S; Saini, JS; Behera, DB; Karanjai, K; Iyer, PS; Gharat, LA; Das, S Glenmark Research Centre http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50011502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50011502&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 49783666 103924055 CHEMBL3261926 ZINC36271864 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51406539 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)[C@@H]1COCCN1 InChI=1S/C21H20N4O2/c22-12-16-3-7-18(8-4-16)17-5-1-15(2-6-17)11-19(13-23)25-21(26)20-14-27-10-9-24-20/h1-8,19-20,24H,9-11,14H2,(H,25,26)/t19-,20-/m0/s1 CGYMVFKSSDCCLP-PMACEKPBSA-N 50568306 CHEMBL4846681 Dipeptidyl peptidase 1 9724 ChEMBL 10.1016/j.bmcl.2021.128202 10.7270/Q2PR80R9 34139325 Banerjee, A; Velagaleti, R; Patil, S; Pawar, M; Yadav, P; Kadam, P; Qadri, MM; Chakraborti, S; Saini, JS; Behera, DB; Karanjai, K; Iyer, PS; Gharat, LA; Das, S Glenmark Research Centre http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568306 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568306&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 164608929 471058451 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51406540 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)[C@@H]1CC2(CCC2)CN1 InChI=1S/C24H24N4O/c25-14-18-4-8-20(9-5-18)19-6-2-17(3-7-19)12-21(15-26)28-23(29)22-13-24(16-27-22)10-1-11-24/h2-9,21-22,27H,1,10-13,16H2,(H,28,29)/t21-,22-/m0/s1 ZLCLFCKFQSXRSX-VXKWHMMOSA-N 50568309 CHEMBL4864151 Dipeptidyl peptidase 1 150 ChEMBL 10.1016/j.bmcl.2021.128202 10.7270/Q2PR80R9 34139325 Banerjee, A; Velagaleti, R; Patil, S; Pawar, M; Yadav, P; Kadam, P; Qadri, MM; Chakraborti, S; Saini, JS; Behera, DB; Karanjai, K; Iyer, PS; Gharat, LA; Das, S Glenmark Research Centre http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568309&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 164624505 471058454 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51406541 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)[C@@H]1CC2(CCCC2)CN1 InChI=1S/C25H26N4O/c26-15-19-5-9-21(10-6-19)20-7-3-18(4-8-20)13-22(16-27)29-24(30)23-14-25(17-28-23)11-1-2-12-25/h3-10,22-23,28H,1-2,11-14,17H2,(H,29,30)/t22-,23-/m0/s1 OVGNUQWZCUMSOX-GOTSBHOMSA-N 50568310 CHEMBL4875554 Dipeptidyl peptidase 1 69 ChEMBL 10.1016/j.bmcl.2021.128202 10.7270/Q2PR80R9 34139325 Banerjee, A; Velagaleti, R; Patil, S; Pawar, M; Yadav, P; Kadam, P; Qadri, MM; Chakraborti, S; Saini, JS; Behera, DB; Karanjai, K; Iyer, PS; Gharat, LA; Das, S Glenmark Research Centre http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568310 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568310&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 164629084 471058455 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51406542 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)[C@@H]1C[C@H]2CCC[C@H]2N1 InChI=1S/C24H24N4O/c25-14-17-6-10-19(11-7-17)18-8-4-16(5-9-18)12-21(15-26)27-24(29)23-13-20-2-1-3-22(20)28-23/h4-11,20-23,28H,1-3,12-13H2,(H,27,29)/t20-,21+,22-,23+/m1/s1 IXUTYJAXGFAXCL-ACESQOTJSA-N 50568313 CHEMBL4854705 Dipeptidyl peptidase 1 79 ChEMBL 10.1016/j.bmcl.2021.128202 10.7270/Q2PR80R9 34139325 Banerjee, A; Velagaleti, R; Patil, S; Pawar, M; Yadav, P; Kadam, P; Qadri, MM; Chakraborti, S; Saini, JS; Behera, DB; Karanjai, K; Iyer, PS; Gharat, LA; Das, S Glenmark Research Centre http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568313 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568313&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 164611822 471058458 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51406543 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)[C@@H]1C[C@@H]2CCC[C@@H]2N1 InChI=1S/C24H24N4O/c25-14-17-6-10-19(11-7-17)18-8-4-16(5-9-18)12-21(15-26)27-24(29)23-13-20-2-1-3-22(20)28-23/h4-11,20-23,28H,1-3,12-13H2,(H,27,29)/t20-,21-,22-,23-/m0/s1 IXUTYJAXGFAXCL-MLCQCVOFSA-N 50568314 CHEMBL4856217 Dipeptidyl peptidase 1 699 ChEMBL 10.1016/j.bmcl.2021.128202 10.7270/Q2PR80R9 34139325 Banerjee, A; Velagaleti, R; Patil, S; Pawar, M; Yadav, P; Kadam, P; Qadri, MM; Chakraborti, S; Saini, JS; Behera, DB; Karanjai, K; Iyer, PS; Gharat, LA; Das, S Glenmark Research Centre http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568314 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568314&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 164610837 471058459 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51406544 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)[C@@H]1C[C@@H]2CCCC[C@@H]2N1 InChI=1S/C25H26N4O/c26-15-18-7-11-20(12-8-18)19-9-5-17(6-10-19)13-22(16-27)28-25(30)24-14-21-3-1-2-4-23(21)29-24/h5-12,21-24,29H,1-4,13-14H2,(H,28,30)/t21-,22-,23-,24-/m0/s1 YWDTXSLPEZCSQO-ZJZGAYNASA-N 50568315 CHEMBL4876996 Dipeptidyl peptidase 1 1716 ChEMBL 10.1016/j.bmcl.2021.128202 10.7270/Q2PR80R9 34139325 Banerjee, A; Velagaleti, R; Patil, S; Pawar, M; Yadav, P; Kadam, P; Qadri, MM; Chakraborti, S; Saini, JS; Behera, DB; Karanjai, K; Iyer, PS; Gharat, LA; Das, S Glenmark Research Centre http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50568315 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50568315&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 164627050 471058460 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420464 FC(F)(F)Oc1cccc(Nc2nc(Nc3ccccc3)ncc2Cl)c1 InChI=1S/C17H12ClF3N4O/c18-14-10-22-16(24-11-5-2-1-3-6-11)25-15(14)23-12-7-4-8-13(9-12)26-17(19,20)21/h1-10H,(H2,22,23,24,25) AJHZEYSQHXGBRL-UHFFFAOYSA-N 50573762 CHEMBL4847625 Dipeptidyl peptidase 1 985 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573762 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573762&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768833 471063907 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420465 Clc1cnc(Nc2ccccc2)nc1Nc1ccccc1 InChI=1S/C16H13ClN4/c17-14-11-18-16(20-13-9-5-2-6-10-13)21-15(14)19-12-7-3-1-4-8-12/h1-11H,(H2,18,19,20,21) ZCCLEHKHPBKZTM-UHFFFAOYSA-N 379199 5-chloro-N2,N4-diphenylpyrimidine-2,4-diamine::US10266549, Example 114::US10774092, Example 114 Dipeptidyl peptidase 1 >5000 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=379199 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=379199&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 89906611 404339182 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420466 Cc1cccc(Nc2nc(Nc3ccccc3)ncc2Cl)c1 InChI=1S/C17H15ClN4/c1-12-6-5-9-14(10-12)20-16-15(18)11-19-17(22-16)21-13-7-3-2-4-8-13/h2-11H,1H3,(H2,19,20,21,22) MKWWAMHXYMNMNC-UHFFFAOYSA-N 50573763 CHEMBL4878722 Dipeptidyl peptidase 1 >5000 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573763 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573763&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768866 471063908 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420467 COc1cccc(Nc2nc(Nc3ccccc3)ncc2Cl)c1 InChI=1S/C17H15ClN4O/c1-23-14-9-5-8-13(10-14)20-16-15(18)11-19-17(22-16)21-12-6-3-2-4-7-12/h2-11H,1H3,(H2,19,20,21,22) SNNAVAVCYVKNTI-UHFFFAOYSA-N 50573764 CHEMBL4850343 Dipeptidyl peptidase 1 >5000 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573764 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573764&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768830 471063909 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420468 CCc1cccc(Nc2nc(Nc3ccccc3)ncc2Cl)c1 InChI=1S/C18H17ClN4/c1-2-13-7-6-10-15(11-13)21-17-16(19)12-20-18(23-17)22-14-8-4-3-5-9-14/h3-12H,2H2,1H3,(H2,20,21,22,23) NCFCOASMBVDFOB-UHFFFAOYSA-N 50573765 CHEMBL4853241 Dipeptidyl peptidase 1 >5000 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573765&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768849 471063910 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420469 CC(C)c1cccc(Nc2nc(Nc3ccccc3)ncc2Cl)c1 InChI=1S/C19H19ClN4/c1-13(2)14-7-6-10-16(11-14)22-18-17(20)12-21-19(24-18)23-15-8-4-3-5-9-15/h3-13H,1-2H3,(H2,21,22,23,24) GQEQGXDUSFHPJO-UHFFFAOYSA-N 50573766 CHEMBL4858039 Dipeptidyl peptidase 1 >5000 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573766 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573766&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768843 471063911 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420470 CC(=O)Nc1cccc(Nc2nc(Nc3ccccc3)ncc2Cl)c1 InChI=1S/C18H16ClN5O/c1-12(25)21-14-8-5-9-15(10-14)22-17-16(19)11-20-18(24-17)23-13-6-3-2-4-7-13/h2-11H,1H3,(H,21,25)(H2,20,22,23,24) YURBRIGTAFPRRS-UHFFFAOYSA-N 50573767 CHEMBL4868238 Dipeptidyl peptidase 1 >5000 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573767 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573767&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768872 471063912 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420471 Fc1cccc(Nc2nc(Nc3ccccc3)ncc2Cl)c1 InChI=1S/C16H12ClFN4/c17-14-10-19-16(21-12-6-2-1-3-7-12)22-15(14)20-13-8-4-5-11(18)9-13/h1-10H,(H2,19,20,21,22) ACEFVIQXQQCZCR-UHFFFAOYSA-N 50573768 CHEMBL4853307 Dipeptidyl peptidase 1 >5000 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573768 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573768&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768853 471063913 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420472 FC(F)(F)c1cccc(Nc2nc(Nc3ccccc3)ncc2Cl)c1 InChI=1S/C17H12ClF3N4/c18-14-10-22-16(24-12-6-2-1-3-7-12)25-15(14)23-13-8-4-5-11(9-13)17(19,20)21/h1-10H,(H2,22,23,24,25) NFXIWZBRMBJQQA-UHFFFAOYSA-N 50573769 CHEMBL4863126 Dipeptidyl peptidase 1 678 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573769 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573769&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768858 471063914 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420473 Fc1ccc(Nc2nc(Nc3ccccc3)ncc2Cl)cc1 InChI=1S/C16H12ClFN4/c17-14-10-19-16(21-12-4-2-1-3-5-12)22-15(14)20-13-8-6-11(18)7-9-13/h1-10H,(H2,19,20,21,22) SYLYJIXJWLDFEW-UHFFFAOYSA-N 50573770 CHEMBL4864687 Dipeptidyl peptidase 1 >5000 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573770 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573770&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768852 471063915 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420474 FC(F)(F)c1ccc(Nc2nc(Nc3ccccc3)ncc2Cl)cc1 InChI=1S/C17H12ClF3N4/c18-14-10-22-16(24-12-4-2-1-3-5-12)25-15(14)23-13-8-6-11(7-9-13)17(19,20)21/h1-10H,(H2,22,23,24,25) IQNXVKFNNOMFIM-UHFFFAOYSA-N 50573771 CHEMBL4848953 Dipeptidyl peptidase 1 >5000 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573771&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768869 471063916 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420475 FC(F)(F)Oc1ccc(Nc2nc(Nc3ccccc3)ncc2Cl)cc1 InChI=1S/C17H12ClF3N4O/c18-14-10-22-16(24-11-4-2-1-3-5-11)25-15(14)23-12-6-8-13(9-7-12)26-17(19,20)21/h1-10H,(H2,22,23,24,25) ATVUPPHKIBIGDN-UHFFFAOYSA-N 50573772 CHEMBL4858957 Dipeptidyl peptidase 1 2082 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573772&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768871 471063917 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420476 Fc1ccc(Nc2nc(Nc3ccccc3)ncc2Cl)cc1C(F)(F)F InChI=1S/C17H11ClF4N4/c18-13-9-23-16(25-10-4-2-1-3-5-10)26-15(13)24-11-6-7-14(19)12(8-11)17(20,21)22/h1-9H,(H2,23,24,25,26) IWBJSTHJGJGCJM-UHFFFAOYSA-N 50573773 CHEMBL4868722 Dipeptidyl peptidase 1 >5000 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573773&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768854 471063918 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420477 FC(F)(F)c1cccc(Nc2nc(NC3CC3)ncc2Cl)c1 InChI=1S/C14H12ClF3N4/c15-11-7-19-13(21-9-4-5-9)22-12(11)20-10-3-1-2-8(6-10)14(16,17)18/h1-3,6-7,9H,4-5H2,(H2,19,20,21,22) WNCUWMZRUICUHZ-UHFFFAOYSA-N 50573774 CHEMBL4846262 Dipeptidyl peptidase 1 >5000 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573774 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573774&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768860 471063919 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420478 FC(F)(F)c1cccc(Nc2nc(NC3CCCC3)ncc2Cl)c1 InChI=1S/C16H16ClF3N4/c17-13-9-21-15(23-11-5-1-2-6-11)24-14(13)22-12-7-3-4-10(8-12)16(18,19)20/h3-4,7-9,11H,1-2,5-6H2,(H2,21,22,23,24) ULAGPFBZUSMUJH-UHFFFAOYSA-N 50573775 CHEMBL4870931 Dipeptidyl peptidase 1 >5000 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573775 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573775&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768855 471063920 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420479 FC(F)(F)c1cccc(Nc2nc(NC3CCCCC3)ncc2Cl)c1 InChI=1S/C17H18ClF3N4/c18-14-10-22-16(24-12-6-2-1-3-7-12)25-15(14)23-13-8-4-5-11(9-13)17(19,20)21/h4-5,8-10,12H,1-3,6-7H2,(H2,22,23,24,25) DLNHNOUISPOGPK-UHFFFAOYSA-N 50573776 CHEMBL4845784 Dipeptidyl peptidase 1 2625 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573776 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573776&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768810 471063921 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420480 FC(F)(F)c1cccc(Nc2nc(NCCc3ccccc3)ncc2Cl)c1 InChI=1S/C19H16ClF3N4/c20-16-12-25-18(24-10-9-13-5-2-1-3-6-13)27-17(16)26-15-8-4-7-14(11-15)19(21,22)23/h1-8,11-12H,9-10H2,(H2,24,25,26,27) HIEHSHUIEFQXBZ-UHFFFAOYSA-N 50573777 CHEMBL4858011 Dipeptidyl peptidase 1 >5000 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573777 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573777&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768825 471063922 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420481 FC(F)(F)c1cccc(Nc2nc(NCCCc3ccccc3)ncc2Cl)c1 InChI=1S/C20H18ClF3N4/c21-17-13-26-19(25-11-5-8-14-6-2-1-3-7-14)28-18(17)27-16-10-4-9-15(12-16)20(22,23)24/h1-4,6-7,9-10,12-13H,5,8,11H2,(H2,25,26,27,28) BDJBQDWXWDLZTM-UHFFFAOYSA-N 50573778 CHEMBL4872742 Dipeptidyl peptidase 1 2022 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573778 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573778&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 164621600 471063923 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420482 Cc1ccc(Nc2ncc(Cl)c(Nc3cccc(c3)C(F)(F)F)n2)cc1 InChI=1S/C18H14ClF3N4/c1-11-5-7-13(8-6-11)25-17-23-10-15(19)16(26-17)24-14-4-2-3-12(9-14)18(20,21)22/h2-10H,1H3,(H2,23,24,25,26) WWXQIPDLIYOUOO-UHFFFAOYSA-N 50573779 CHEMBL4851862 Dipeptidyl peptidase 1 >5000 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573779&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768832 471063924 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420483 COc1ccc(Nc2ncc(Cl)c(Nc3cccc(c3)C(F)(F)F)n2)cc1 InChI=1S/C18H14ClF3N4O/c1-27-14-7-5-12(6-8-14)25-17-23-10-15(19)16(26-17)24-13-4-2-3-11(9-13)18(20,21)22/h2-10H,1H3,(H2,23,24,25,26) ORQWGZYFYCYUSC-UHFFFAOYSA-N 50573780 CHEMBL4849743 Dipeptidyl peptidase 1 >5000 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573780 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573780&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768837 471063925 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420484 CCc1ccc(Nc2ncc(Cl)c(Nc3cccc(c3)C(F)(F)F)n2)cc1 InChI=1S/C19H16ClF3N4/c1-2-12-6-8-14(9-7-12)26-18-24-11-16(20)17(27-18)25-15-5-3-4-13(10-15)19(21,22)23/h3-11H,2H2,1H3,(H2,24,25,26,27) FHWJQSYTFOBESE-UHFFFAOYSA-N 50573781 CHEMBL4864694 Dipeptidyl peptidase 1 >5000 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573781 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573781&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768835 471063926 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420485 CC(C)c1ccc(Nc2ncc(Cl)c(Nc3cccc(c3)C(F)(F)F)n2)cc1 InChI=1S/C20H18ClF3N4/c1-12(2)13-6-8-15(9-7-13)27-19-25-11-17(21)18(28-19)26-16-5-3-4-14(10-16)20(22,23)24/h3-12H,1-2H3,(H2,25,26,27,28) CYMPMXLMYWLEFV-UHFFFAOYSA-N 50573782 CHEMBL4876855 Dipeptidyl peptidase 1 >5000 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573782 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573782&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768816 471063927 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420486 CC(C)(C)c1ccc(Nc2ncc(Cl)c(Nc3cccc(c3)C(F)(F)F)n2)cc1 InChI=1S/C21H20ClF3N4/c1-20(2,3)13-7-9-15(10-8-13)28-19-26-12-17(22)18(29-19)27-16-6-4-5-14(11-16)21(23,24)25/h4-12H,1-3H3,(H2,26,27,28,29) QEMREYNXFSAYQQ-UHFFFAOYSA-N 50573783 CHEMBL4878148 Dipeptidyl peptidase 1 >5000 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573783 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573783&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768820 471063928 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420487 Fc1ccc(Nc2ncc(Cl)c(Nc3cccc(c3)C(F)(F)F)n2)cc1 InChI=1S/C17H11ClF4N4/c18-14-9-23-16(25-12-6-4-11(19)5-7-12)26-15(14)24-13-3-1-2-10(8-13)17(20,21)22/h1-9H,(H2,23,24,25,26) UGBDWDUEHMHBDO-UHFFFAOYSA-N 50573784 CHEMBL4849283 Dipeptidyl peptidase 1 785 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573784 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573784&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768813 471063929 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420488 FC(F)(F)Oc1ccc(Nc2ncc(Cl)c(Nc3cccc(c3)C(F)(F)F)n2)cc1 InChI=1S/C18H11ClF6N4O/c19-14-9-26-16(28-11-4-6-13(7-5-11)30-18(23,24)25)29-15(14)27-12-3-1-2-10(8-12)17(20,21)22/h1-9H,(H2,26,27,28,29) GTMQIKCQGDSJKP-UHFFFAOYSA-N 50573785 CHEMBL4878972 Dipeptidyl peptidase 1 >5000 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573785 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573785&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768859 471063930 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420489 CC(=O)Nc1ccc(Nc2ncc(Cl)c(Nc3cccc(c3)C(F)(F)F)n2)cc1 InChI=1S/C19H15ClF3N5O/c1-11(29)25-13-5-7-14(8-6-13)27-18-24-10-16(20)17(28-18)26-15-4-2-3-12(9-15)19(21,22)23/h2-10H,1H3,(H,25,29)(H2,24,26,27,28) TZOZVGDATPYOJO-UHFFFAOYSA-N 50573786 CHEMBL4873859 Dipeptidyl peptidase 1 >5000 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573786&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 164619885 471063931 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420490 NC(=O)c1ccc(Nc2ncc(Cl)c(Nc3cccc(c3)C(F)(F)F)n2)cc1 InChI=1S/C18H13ClF3N5O/c19-14-9-24-17(26-12-6-4-10(5-7-12)15(23)28)27-16(14)25-13-3-1-2-11(8-13)18(20,21)22/h1-9H,(H2,23,28)(H2,24,25,26,27) BSFXZTXKQLFEES-UHFFFAOYSA-N 50573787 CHEMBL4849359 Dipeptidyl peptidase 1 >5000 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573787&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768851 471063932 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420491 CS(=O)(=O)c1ccc(Nc2ncc(Cl)c(Nc3cccc(c3)C(F)(F)F)n2)cc1 InChI=1S/C18H14ClF3N4O2S/c1-29(27,28)14-7-5-12(6-8-14)25-17-23-10-15(19)16(26-17)24-13-4-2-3-11(9-13)18(20,21)22/h2-10H,1H3,(H2,23,24,25,26) LWSQFAIGIKDIAE-UHFFFAOYSA-N 50573788 CHEMBL4849764 Dipeptidyl peptidase 1 >5000 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573788&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768818 471063933 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420492 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(cc3)C#N)ncc2Cl)c1 InChI=1S/C18H11ClF3N5/c19-15-10-24-17(26-13-6-4-11(9-23)5-7-13)27-16(15)25-14-3-1-2-12(8-14)18(20,21)22/h1-8,10H,(H2,24,25,26,27) QFUJJJQNBFLSED-UHFFFAOYSA-N 50573789 CHEMBL4849942 Dipeptidyl peptidase 1 >5000 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573789&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768841 471063934 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420493 FC(F)(F)c1cccc(Nc2nc(NCCc3ccccn3)ncc2Cl)c1 InChI=1S/C18H15ClF3N5/c19-15-11-25-17(24-9-7-13-5-1-2-8-23-13)27-16(15)26-14-6-3-4-12(10-14)18(20,21)22/h1-6,8,10-11H,7,9H2,(H2,24,25,26,27) ITYPMNZQMKTPKB-UHFFFAOYSA-N 50573790 CHEMBL4850290 Dipeptidyl peptidase 1 >5000 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573790&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768822 471063935 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420494 FC(F)(F)c1cccc(Nc2nc(NCCc3cccnc3)ncc2Cl)c1 InChI=1S/C18H15ClF3N5/c19-15-11-25-17(24-8-6-12-3-2-7-23-10-12)27-16(15)26-14-5-1-4-13(9-14)18(20,21)22/h1-5,7,9-11H,6,8H2,(H2,24,25,26,27) HUVYYKYXIABJOQ-UHFFFAOYSA-N 50573791 CHEMBL4850020 Dipeptidyl peptidase 1 >5000 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573791&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768817 471063936 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420495 FC(F)(F)c1cccc(Nc2nc(NCCc3ccncc3)ncc2Cl)c1 InChI=1S/C18H15ClF3N5/c19-15-11-25-17(24-9-6-12-4-7-23-8-5-12)27-16(15)26-14-3-1-2-13(10-14)18(20,21)22/h1-5,7-8,10-11H,6,9H2,(H2,24,25,26,27) IARMHUDFYIGNJA-UHFFFAOYSA-N 50573792 CHEMBL4849004 Dipeptidyl peptidase 1 >5000 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573792&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 164614922 471063937 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420496 FC(F)(F)c1cccc(Nc2nc(NCCCc3ccccn3)ncc2Cl)c1 InChI=1S/C19H17ClF3N5/c20-16-12-26-18(25-10-4-8-14-6-1-2-9-24-14)28-17(16)27-15-7-3-5-13(11-15)19(21,22)23/h1-3,5-7,9,11-12H,4,8,10H2,(H2,25,26,27,28) GBOGQWVPHDQWBO-UHFFFAOYSA-N 50573793 CHEMBL4847414 Dipeptidyl peptidase 1 >5000 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573793&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 164613231 471063938 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420497 FC(F)(F)c1cccc(Nc2nc(NCCCc3cccnc3)ncc2Cl)c1 InChI=1S/C19H17ClF3N5/c20-16-12-26-18(25-9-3-5-13-4-2-8-24-11-13)28-17(16)27-15-7-1-6-14(10-15)19(21,22)23/h1-2,4,6-8,10-12H,3,5,9H2,(H2,25,26,27,28) BUIGKUXRWHAEEI-UHFFFAOYSA-N 50573794 CHEMBL4852044 Dipeptidyl peptidase 1 >5000 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573794&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 164613952 471063939 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420498 FC(F)(F)c1cccc(Nc2nc(Nc3ccccn3)ncc2Cl)c1 InChI=1S/C16H11ClF3N5/c17-12-9-22-15(24-13-6-1-2-7-21-13)25-14(12)23-11-5-3-4-10(8-11)16(18,19)20/h1-9H,(H2,21,22,23,24,25) UYKZDUHNCAAXGK-UHFFFAOYSA-N 50573795 CHEMBL4864926 Dipeptidyl peptidase 1 296 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573795&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768819 471063940 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420499 FC(F)(F)c1cccc(Nc2nc(Nc3cccnc3)ncc2Cl)c1 InChI=1S/C16H11ClF3N5/c17-13-9-22-15(24-12-5-2-6-21-8-12)25-14(13)23-11-4-1-3-10(7-11)16(18,19)20/h1-9H,(H2,22,23,24,25) GESFFVXKERNGNK-UHFFFAOYSA-N 50573796 CHEMBL4876934 Dipeptidyl peptidase 1 417 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573796&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768836 471063941 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420500 FC(F)(F)c1cccc(Nc2nc(Nc3ccncc3)ncc2Cl)c1 InChI=1S/C16H11ClF3N5/c17-13-9-22-15(24-11-4-6-21-7-5-11)25-14(13)23-12-3-1-2-10(8-12)16(18,19)20/h1-9H,(H2,21,22,23,24,25) BSNSWGWISOBVIP-UHFFFAOYSA-N 50573797 CHEMBL4846716 Dipeptidyl peptidase 1 2989 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573797&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768867 471063942 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420501 FC(F)(F)c1cccc(Nc2nc(Nc3cncnc3)ncc2Cl)c1 InChI=1S/C15H10ClF3N6/c16-12-7-22-14(24-11-5-20-8-21-6-11)25-13(12)23-10-3-1-2-9(4-10)15(17,18)19/h1-8H,(H2,22,23,24,25) FHUDSNATRGHUNK-UHFFFAOYSA-N 50573798 CHEMBL4876235 Dipeptidyl peptidase 1 1990 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573798&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768827 471063943 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420502 FC(F)(F)c1cccc(Nc2nc(Nc3cccnn3)ncc2Cl)c1 InChI=1S/C15H10ClF3N6/c16-11-8-20-14(23-12-5-2-6-21-25-12)24-13(11)22-10-4-1-3-9(7-10)15(17,18)19/h1-8H,(H2,20,22,23,24,25) XBUASUBEROZIQU-UHFFFAOYSA-N 50573799 CHEMBL4875918 Dipeptidyl peptidase 1 1561 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573799&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768823 471063944 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420503 CN1CCN(CC1)c1ccc(Nc2ncc(Cl)c(Nc3cccc(c3)C(F)(F)F)n2)cc1 InChI=1S/C22H22ClF3N6/c1-31-9-11-32(12-10-31)18-7-5-16(6-8-18)29-21-27-14-19(23)20(30-21)28-17-4-2-3-15(13-17)22(24,25)26/h2-8,13-14H,9-12H2,1H3,(H2,27,28,29,30) CJGXYTXDCLOCPM-UHFFFAOYSA-N 50573800 CHEMBL4862932 Dipeptidyl peptidase 1 142 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573800&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768811 471063945 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420504 CN1CCN(CC1)c1ccc(Nc2ncc(Cl)c(Nc3cccc(c3)C(F)(F)F)n2)nc1 InChI=1S/C21H21ClF3N7/c1-31-7-9-32(10-8-31)16-5-6-18(26-12-16)29-20-27-13-17(22)19(30-20)28-15-4-2-3-14(11-15)21(23,24)25/h2-6,11-13H,7-10H2,1H3,(H2,26,27,28,29,30) JNAOGJWOQFVLOM-UHFFFAOYSA-N 50573801 CHEMBL4859234 Dipeptidyl peptidase 1 57 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573801&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768862 471063946 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420505 CN1CCN(CC1)c1ccc(Nc2ncc(Cl)c(Nc3cccc(c3)C(F)(F)F)n2)cn1 InChI=1S/C21H21ClF3N7/c1-31-7-9-32(10-8-31)18-6-5-16(12-26-18)29-20-27-13-17(22)19(30-20)28-15-4-2-3-14(11-15)21(23,24)25/h2-6,11-13H,7-10H2,1H3,(H2,27,28,29,30) YNGWEWBJFQRFCH-UHFFFAOYSA-N 50573802 CHEMBL4875913 Dipeptidyl peptidase 1 136 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573802 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573802&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768844 471063947 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420506 CN1CCN(CC1)c1ncc(Nc2ncc(Cl)c(Nc3cccc(c3)C(F)(F)F)n2)cn1 InChI=1S/C20H20ClF3N8/c1-31-5-7-32(8-6-31)19-26-10-15(11-27-19)29-18-25-12-16(21)17(30-18)28-14-4-2-3-13(9-14)20(22,23)24/h2-4,9-12H,5-8H2,1H3,(H2,25,28,29,30) HETZJTKUZBUOBT-UHFFFAOYSA-N 50573803 CHEMBL4862809 Dipeptidyl peptidase 1 207 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573803 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573803&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768814 471063948 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420507 CN1CCN(CC1)c1ccc(Nc2ncc(Cl)c(Nc3cccc(c3)C(F)(F)F)n2)nn1 InChI=1S/C20H20ClF3N8/c1-31-7-9-32(10-8-31)17-6-5-16(29-30-17)27-19-25-12-15(21)18(28-19)26-14-4-2-3-13(11-14)20(22,23)24/h2-6,11-12H,7-10H2,1H3,(H2,25,26,27,28,29) XYXQHAUYFPXZQW-UHFFFAOYSA-N 50573804 CHEMBL4850792 Dipeptidyl peptidase 1 115 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573804 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573804&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768850 471063949 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420508 CCN1CCN(CC1)c1ccc(Nc2ncc(Cl)c(Nc3cccc(c3)C(F)(F)F)n2)nc1 InChI=1S/C22H23ClF3N7/c1-2-32-8-10-33(11-9-32)17-6-7-19(27-13-17)30-21-28-14-18(23)20(31-21)29-16-5-3-4-15(12-16)22(24,25)26/h3-7,12-14H,2,8-11H2,1H3,(H2,27,28,29,30,31) ZIGDOWJPKOPVRE-UHFFFAOYSA-N 50573805 CHEMBL4852320 Dipeptidyl peptidase 1 58 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573805 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573805&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768848 471063950 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420509 CCCN1CCN(CC1)c1ccc(Nc2ncc(Cl)c(Nc3cccc(c3)C(F)(F)F)n2)nc1 InChI=1S/C23H25ClF3N7/c1-2-8-33-9-11-34(12-10-33)18-6-7-20(28-14-18)31-22-29-15-19(24)21(32-22)30-17-5-3-4-16(13-17)23(25,26)27/h3-7,13-15H,2,8-12H2,1H3,(H2,28,29,30,31,32) IGQCCPXSHBTJOW-UHFFFAOYSA-N 50573806 CHEMBL4853612 Dipeptidyl peptidase 1 92 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573806 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573806&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768870 471063951 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420510 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(cn3)N3CCN(CC3)C3CC3)ncc2Cl)c1 InChI=1S/C23H23ClF3N7/c24-19-14-29-22(32-21(19)30-16-3-1-2-15(12-16)23(25,26)27)31-20-7-6-18(13-28-20)34-10-8-33(9-11-34)17-4-5-17/h1-3,6-7,12-14,17H,4-5,8-11H2,(H2,28,29,30,31,32) FQBJTPXARACKIP-UHFFFAOYSA-N 50573807 CHEMBL4848848 Dipeptidyl peptidase 1 982 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573807&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 164618324 471063952 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420511 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(cn3)N3CCN4CCCCC4C3)ncc2Cl)c1 InChI=1S/C24H25ClF3N7/c25-20-14-30-23(33-22(20)31-17-5-3-4-16(12-17)24(26,27)28)32-21-8-7-18(13-29-21)35-11-10-34-9-2-1-6-19(34)15-35/h3-5,7-8,12-14,19H,1-2,6,9-11,15H2,(H2,29,30,31,32,33) QKDRVNVJLPIYKX-UHFFFAOYSA-N 50573808 CHEMBL4854078 Dipeptidyl peptidase 1 202 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573808 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573808&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 164615111 471063953 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420512 CC(=O)N1CCN(CC1)c1ccc(Nc2ncc(Cl)c(Nc3cccc(c3)C(F)(F)F)n2)nc1 InChI=1S/C22H21ClF3N7O/c1-14(34)32-7-9-33(10-8-32)17-5-6-19(27-12-17)30-21-28-13-18(23)20(31-21)29-16-4-2-3-15(11-16)22(24,25)26/h2-6,11-13H,7-10H2,1H3,(H2,27,28,29,30,31) YLTAJZAGZXAKKF-UHFFFAOYSA-N 50573809 CHEMBL4859374 Dipeptidyl peptidase 1 308 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573809&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 164616459 471063954 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420513 CCC(=O)N1CCN(CC1)c1ccc(Nc2ncc(Cl)c(Nc3cccc(c3)C(F)(F)F)n2)nc1 InChI=1S/C23H23ClF3N7O/c1-2-20(35)34-10-8-33(9-11-34)17-6-7-19(28-13-17)31-22-29-14-18(24)21(32-22)30-16-5-3-4-15(12-16)23(25,26)27/h3-7,12-14H,2,8-11H2,1H3,(H2,28,29,30,31,32) YFAQNAYNPSNHOI-UHFFFAOYSA-N 50573810 CHEMBL4869038 Dipeptidyl peptidase 1 >5000 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573810 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573810&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 164621483 471063955 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420514 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(cn3)N3CCNCC3)ncc2Cl)c1 InChI=1S/C20H19ClF3N7/c21-16-12-27-19(29-17-5-4-15(11-26-17)31-8-6-25-7-9-31)30-18(16)28-14-3-1-2-13(10-14)20(22,23)24/h1-5,10-12,25H,6-9H2,(H2,26,27,28,29,30) XRNBLQBDZUJCOL-UHFFFAOYSA-N 50573811 CHEMBL4873553 Dipeptidyl peptidase 1 79 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573811&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 164622083 471063956 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420515 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(cn3)N3CCCCC3)ncc2Cl)c1 InChI=1S/C21H20ClF3N6/c22-17-13-27-20(29-18-8-7-16(12-26-18)31-9-2-1-3-10-31)30-19(17)28-15-6-4-5-14(11-15)21(23,24)25/h4-8,11-13H,1-3,9-10H2,(H2,26,27,28,29,30) UITIIOFWPMZWEO-UHFFFAOYSA-N 50573812 CHEMBL4850658 Dipeptidyl peptidase 1 >5000 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573812 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573812&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768875 471063957 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420516 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(cn3)N3CCOCC3)ncc2Cl)c1 InChI=1S/C20H18ClF3N6O/c21-16-12-26-19(28-17-5-4-15(11-25-17)30-6-8-31-9-7-30)29-18(16)27-14-3-1-2-13(10-14)20(22,23)24/h1-5,10-12H,6-9H2,(H2,25,26,27,28,29) RDHOWKSYWVOAEK-UHFFFAOYSA-N 50573813 CHEMBL4848142 Dipeptidyl peptidase 1 >5000 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573813 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573813&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 164613244 471063958 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420517 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(cn3)N3CCSCC3)ncc2Cl)c1 InChI=1S/C20H18ClF3N6S/c21-16-12-26-19(28-17-5-4-15(11-25-17)30-6-8-31-9-7-30)29-18(16)27-14-3-1-2-13(10-14)20(22,23)24/h1-5,10-12H,6-9H2,(H2,25,26,27,28,29) LZJJKANATVKZKL-UHFFFAOYSA-N 50573814 CHEMBL4850341 Dipeptidyl peptidase 1 408 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573814&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768842 471063959 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420518 NC1CCN(CC1)c1ccc(Nc2ncc(Cl)c(Nc3cccc(c3)C(F)(F)F)n2)nc1 InChI=1S/C21H21ClF3N7/c22-17-12-28-20(31-19(17)29-15-3-1-2-13(10-15)21(23,24)25)30-18-5-4-16(11-27-18)32-8-6-14(26)7-9-32/h1-5,10-12,14H,6-9,26H2,(H2,27,28,29,30,31) BWFNOCLZALFPLG-UHFFFAOYSA-N 50573815 CHEMBL4875426 Dipeptidyl peptidase 1 87 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573815 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573815&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768873 471063960 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420519 CN(C)C1CCN(CC1)c1ccc(Nc2ncc(Cl)c(Nc3cccc(c3)C(F)(F)F)n2)nc1 InChI=1S/C23H25ClF3N7/c1-33(2)17-8-10-34(11-9-17)18-6-7-20(28-13-18)31-22-29-14-19(24)21(32-22)30-16-5-3-4-15(12-16)23(25,26)27/h3-7,12-14,17H,8-11H2,1-2H3,(H2,28,29,30,31,32) PBJMGYJAKOSSSQ-UHFFFAOYSA-N 50573816 CHEMBL4869755 Dipeptidyl peptidase 1 33 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573816 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573816&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768828 471063961 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420520 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(cn3)N3CCC(CC3)C#N)ncc2Cl)c1 InChI=1S/C22H19ClF3N7/c23-18-13-29-21(32-20(18)30-16-3-1-2-15(10-16)22(24,25)26)31-19-5-4-17(12-28-19)33-8-6-14(11-27)7-9-33/h1-5,10,12-14H,6-9H2,(H2,28,29,30,31,32) SKDZSRRQCPNGCB-UHFFFAOYSA-N 50573817 CHEMBL4852920 Dipeptidyl peptidase 1 >5000 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573817&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768824 471063962 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420521 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(cn3)-c3ccccc3)ncc2Cl)c1 InChI=1S/C22H15ClF3N5/c23-18-13-28-21(30-19-10-9-15(12-27-19)14-5-2-1-3-6-14)31-20(18)29-17-8-4-7-16(11-17)22(24,25)26/h1-13H,(H2,27,28,29,30,31) ICOKEPHBAONPHG-UHFFFAOYSA-N 50573818 CHEMBL4853461 Dipeptidyl peptidase 1 214 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573818 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573818&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768874 471063963 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420522 Nc1ccc(cc1)-c1ccc(Nc2ncc(Cl)c(Nc3cccc(c3)C(F)(F)F)n2)nc1 InChI=1S/C22H16ClF3N6/c23-18-12-29-21(32-20(18)30-17-3-1-2-15(10-17)22(24,25)26)31-19-9-6-14(11-28-19)13-4-7-16(27)8-5-13/h1-12H,27H2,(H2,28,29,30,31,32) ACTYGNXJGLFMRG-UHFFFAOYSA-N 50573819 CHEMBL4879107 Dipeptidyl peptidase 1 158 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573819&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768815 471063964 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420523 CN(C)c1ccc(cc1)-c1ccc(Nc2ncc(Cl)c(Nc3cccc(c3)C(F)(F)F)n2)nc1 InChI=1S/C24H20ClF3N6/c1-34(2)19-9-6-15(7-10-19)16-8-11-21(29-13-16)32-23-30-14-20(25)22(33-23)31-18-5-3-4-17(12-18)24(26,27)28/h3-14H,1-2H3,(H2,29,30,31,32,33) XXOZKOQBZDSJCB-UHFFFAOYSA-N 50573820 CHEMBL4867247 Dipeptidyl peptidase 1 62 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573820&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768826 471063965 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420524 Cn1cc(cn1)-c1ccc(Nc2ncc(Cl)c(Nc3cccc(c3)C(F)(F)F)n2)nc1 InChI=1S/C20H15ClF3N7/c1-31-11-13(9-27-31)12-5-6-17(25-8-12)29-19-26-10-16(21)18(30-19)28-15-4-2-3-14(7-15)20(22,23)24/h2-11H,1H3,(H2,25,26,28,29,30) YTXYIJYKTPPNAA-UHFFFAOYSA-N 50573821 CHEMBL4875086 Dipeptidyl peptidase 1 305 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573821&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 164628181 471063966 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420525 Cc1noc(C)c1-c1ccc(Nc2ncc(Cl)c(Nc3cccc(c3)C(F)(F)F)n2)nc1 InChI=1S/C21H16ClF3N6O/c1-11-18(12(2)32-31-11)13-6-7-17(26-9-13)29-20-27-10-16(22)19(30-20)28-15-5-3-4-14(8-15)21(23,24)25/h3-10H,1-2H3,(H2,26,27,28,29,30) UHQMOPPHCWDJBV-UHFFFAOYSA-N 50573822 CHEMBL4861328 Dipeptidyl peptidase 1 >5000 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573822&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768868 471063967 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420526 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(cn3)-c3ccoc3)ncc2Cl)c1 InChI=1S/C20H13ClF3N5O/c21-16-10-26-19(28-17-5-4-12(9-25-17)13-6-7-30-11-13)29-18(16)27-15-3-1-2-14(8-15)20(22,23)24/h1-11H,(H2,25,26,27,28,29) YUDMMRRZXOZNCH-UHFFFAOYSA-N 50573823 CHEMBL4855016 Dipeptidyl peptidase 1 >5000 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573823&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768863 471063968 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420527 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2Cl)c1 InChI=1S/C20H13ClF3N5S/c21-16-10-26-19(28-17-5-4-12(9-25-17)13-6-7-30-11-13)29-18(16)27-15-3-1-2-14(8-15)20(22,23)24/h1-11H,(H2,25,26,27,28,29) WRTIVQWHCXIVQC-UHFFFAOYSA-N 50573824 CHEMBL4847055 Dipeptidyl peptidase 1 57 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573824&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768840 471063969 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420528 CN1CCN(CC1)c1ccc(Nc2ncc(F)c(Nc3cccc(c3)C(F)(F)F)n2)nc1 InChI=1S/C21H21F4N7/c1-31-7-9-32(10-8-31)16-5-6-18(26-12-16)29-20-27-13-17(22)19(30-20)28-15-4-2-3-14(11-15)21(23,24)25/h2-6,11-13H,7-10H2,1H3,(H2,26,27,28,29,30) VECHFXRWBBRITA-UHFFFAOYSA-N 50573825 CHEMBL4861702 Dipeptidyl peptidase 1 57 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573825&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768846 471063970 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420529 CN1CCN(CC1)c1ccc(Nc2ncc(C)c(Nc3cccc(c3)C(F)(F)F)n2)nc1 InChI=1S/C22H24F3N7/c1-15-13-27-21(30-20(15)28-17-5-3-4-16(12-17)22(23,24)25)29-19-7-6-18(14-26-19)32-10-8-31(2)9-11-32/h3-7,12-14H,8-11H2,1-2H3,(H2,26,27,28,29,30) RBBYYHZBGMYZJC-UHFFFAOYSA-N 50573826 CHEMBL4865601 Dipeptidyl peptidase 1 210 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573826&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768856 471063971 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420530 COc1cnc(Nc2ccc(cn2)N2CCN(C)CC2)nc1Nc1cccc(c1)C(F)(F)F InChI=1S/C22H24F3N7O/c1-31-8-10-32(11-9-31)17-6-7-19(26-13-17)29-21-27-14-18(33-2)20(30-21)28-16-5-3-4-15(12-16)22(23,24)25/h3-7,12-14H,8-11H2,1-2H3,(H2,26,27,28,29,30) CJLNZTBMZGIQQO-UHFFFAOYSA-N 50573827 CHEMBL4846401 Dipeptidyl peptidase 1 179 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573827&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 164609596 471063972 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420531 FC(F)(F)c1cccc(Nc2ccnc(Nc3ccc(cn3)-c3ccsc3)n2)c1 InChI=1S/C20H14F3N5S/c21-20(22,23)15-2-1-3-16(10-15)26-18-6-8-24-19(28-18)27-17-5-4-13(11-25-17)14-7-9-29-12-14/h1-12H,(H2,24,25,26,27,28) PKDJMOPRADKMKS-UHFFFAOYSA-N 50573828 CHEMBL4859540 Dipeptidyl peptidase 1 53 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573828&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768812 471063973 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420532 Fc1cnc(Nc2ccc(cn2)-c2ccsc2)nc1Nc1cccc(c1)C(F)(F)F InChI=1S/C20H13F4N5S/c21-16-10-26-19(28-17-5-4-12(9-25-17)13-6-7-30-11-13)29-18(16)27-15-3-1-2-14(8-15)20(22,23)24/h1-11H,(H2,25,26,27,28,29) KRNIWFJLEHEGRG-UHFFFAOYSA-N 50573829 CHEMBL4875307 Dipeptidyl peptidase 1 66 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573829&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768829 471063974 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420533 Cc1cnc(Nc2ccc(cn2)-c2ccsc2)nc1Nc1cccc(c1)C(F)(F)F InChI=1S/C21H16F3N5S/c1-13-10-26-20(28-18-6-5-14(11-25-18)15-7-8-30-12-15)29-19(13)27-17-4-2-3-16(9-17)21(22,23)24/h2-12H,1H3,(H2,25,26,27,28,29) OFOHMVCGHGFMDH-UHFFFAOYSA-N 50573830 CHEMBL4868834 Dipeptidyl peptidase 1 109 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573830&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768834 471063975 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420534 COc1cnc(Nc2ccc(cn2)-c2ccsc2)nc1Nc1cccc(c1)C(F)(F)F InChI=1S/C21H16F3N5OS/c1-30-17-11-26-20(28-18-6-5-13(10-25-18)14-7-8-31-12-14)29-19(17)27-16-4-2-3-15(9-16)21(22,23)24/h2-12H,1H3,(H2,25,26,27,28,29) BZPCXHXAPWYWEV-UHFFFAOYSA-N 50573831 CHEMBL4848242 Dipeptidyl peptidase 1 133 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573831&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768861 471063976 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420535 CN1CCN(CC1)c1ccc(Nc2ncc(Cl)c(Oc3cccc(c3)C(F)(F)F)n2)nc1 InChI=1S/C21H20ClF3N6O/c1-30-7-9-31(10-8-30)15-5-6-18(26-12-15)28-20-27-13-17(22)19(29-20)32-16-4-2-3-14(11-16)21(23,24)25/h2-6,11-13H,7-10H2,1H3,(H,26,27,28,29) MONPBWNFYUPTME-UHFFFAOYSA-N 50573832 CHEMBL4869853 Dipeptidyl peptidase 1 94 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573832 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573832&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 164625201 471063977 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420536 CN1CCN(CC1)c1ccc(Nc2ncc(Cl)c(Oc3cccc(c3)C(F)(F)F)n2)cc1 InChI=1S/C22H21ClF3N5O/c1-30-9-11-31(12-10-30)17-7-5-16(6-8-17)28-21-27-14-19(23)20(29-21)32-18-4-2-3-15(13-18)22(24,25)26/h2-8,13-14H,9-12H2,1H3,(H,27,28,29) ROMPEXMBODHHSH-UHFFFAOYSA-N 50573833 CHEMBL4858382 Dipeptidyl peptidase 1 82 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573833 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573833&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 164610943 471063978 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420537 Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H24N4O4/c1-27-19-12-17(7-8-20(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)21-14-25-9-2-10-30-21/h3-8,12,18,21,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,21-/m0/s1 AEXFXNFMSAAELR-RXVVDRJESA-N 50195235 CHEMBL3900409::US10287258, Example 2::US10669245, Example 2::US11117874, Example 2::US11655221, Example 2::US11680049, Example 2 Dipeptidyl peptidase 1 19 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195235&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253852 375977090 CHEMBL3900409 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420538 FC(F)(F)Oc1cccc(Nc2nc(Nc3ccccc3)ncc2Cl)c1 InChI=1S/C17H12ClF3N4O/c18-14-10-22-16(24-11-5-2-1-3-6-11)25-15(14)23-12-7-4-8-13(9-12)26-17(19,20)21/h1-10H,(H2,22,23,24,25) AJHZEYSQHXGBRL-UHFFFAOYSA-N 50573762 CHEMBL4847625 Dipeptidyl peptidase 1 1050 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573762 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573762&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768833 471063907 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420539 FC(F)(F)c1cccc(Nc2nc(Nc3ccccc3)ncc2Cl)c1 InChI=1S/C17H12ClF3N4/c18-14-10-22-16(24-12-6-2-1-3-7-12)25-15(14)23-13-8-4-5-11(9-13)17(19,20)21/h1-10H,(H2,22,23,24,25) NFXIWZBRMBJQQA-UHFFFAOYSA-N 50573769 CHEMBL4863126 Dipeptidyl peptidase 1 678 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573769 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573769&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768858 471063914 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420540 FC(F)(F)c1cccc(Nc2nc(NC3CCCCC3)ncc2Cl)c1 InChI=1S/C17H18ClF3N4/c18-14-10-22-16(24-12-6-2-1-3-7-12)25-15(14)23-13-8-4-5-11(9-13)17(19,20)21/h4-5,8-10,12H,1-3,6-7H2,(H2,22,23,24,25) DLNHNOUISPOGPK-UHFFFAOYSA-N 50573776 CHEMBL4845784 Dipeptidyl peptidase 1 >3000 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573776 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573776&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768810 471063921 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420541 FC(F)(F)c1cccc(Nc2nc(NCCCc3ccccc3)ncc2Cl)c1 InChI=1S/C20H18ClF3N4/c21-17-13-26-19(25-11-5-8-14-6-2-1-3-7-14)28-18(17)27-16-10-4-9-15(12-16)20(22,23)24/h1-4,6-7,9-10,12-13H,5,8,11H2,(H2,25,26,27,28) BDJBQDWXWDLZTM-UHFFFAOYSA-N 50573778 CHEMBL4872742 Dipeptidyl peptidase 1 >3000 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573778 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573778&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 164621600 471063923 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420542 Fc1ccc(Nc2ncc(Cl)c(Nc3cccc(c3)C(F)(F)F)n2)cc1 InChI=1S/C17H11ClF4N4/c18-14-9-23-16(25-12-6-4-11(19)5-7-12)26-15(14)24-13-3-1-2-10(8-13)17(20,21)22/h1-9H,(H2,23,24,25,26) UGBDWDUEHMHBDO-UHFFFAOYSA-N 50573784 CHEMBL4849283 Dipeptidyl peptidase 1 992 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573784 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573784&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768813 471063929 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420543 FC(F)(F)c1cccc(Nc2nc(Nc3ccccn3)ncc2Cl)c1 InChI=1S/C16H11ClF3N5/c17-12-9-22-15(24-13-6-1-2-7-21-13)25-14(12)23-11-5-3-4-10(8-11)16(18,19)20/h1-9H,(H2,21,22,23,24,25) UYKZDUHNCAAXGK-UHFFFAOYSA-N 50573795 CHEMBL4864926 Dipeptidyl peptidase 1 207 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573795&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768819 471063940 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420544 FC(F)(F)c1cccc(Nc2nc(Nc3cccnc3)ncc2Cl)c1 InChI=1S/C16H11ClF3N5/c17-13-9-22-15(24-12-5-2-6-21-8-12)25-14(13)23-11-4-1-3-10(7-11)16(18,19)20/h1-9H,(H2,22,23,24,25) GESFFVXKERNGNK-UHFFFAOYSA-N 50573796 CHEMBL4876934 Dipeptidyl peptidase 1 294 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573796&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768836 471063941 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420545 FC(F)(F)c1cccc(Nc2nc(Nc3ccncc3)ncc2Cl)c1 InChI=1S/C16H11ClF3N5/c17-13-9-22-15(24-11-4-6-21-7-5-11)25-14(13)23-12-3-1-2-10(8-12)16(18,19)20/h1-9H,(H2,21,22,23,24,25) BSNSWGWISOBVIP-UHFFFAOYSA-N 50573797 CHEMBL4846716 Dipeptidyl peptidase 1 >3000 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573797&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768867 471063942 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420546 FC(F)(F)c1cccc(Nc2nc(Nc3cncnc3)ncc2Cl)c1 InChI=1S/C15H10ClF3N6/c16-12-7-22-14(24-11-5-20-8-21-6-11)25-13(12)23-10-3-1-2-9(4-10)15(17,18)19/h1-8H,(H2,22,23,24,25) FHUDSNATRGHUNK-UHFFFAOYSA-N 50573798 CHEMBL4876235 Dipeptidyl peptidase 1 >3000 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573798&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768827 471063943 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420547 FC(F)(F)c1cccc(Nc2nc(Nc3cccnn3)ncc2Cl)c1 InChI=1S/C15H10ClF3N6/c16-11-8-20-14(23-12-5-2-6-21-25-12)24-13(11)22-10-4-1-3-9(7-10)15(17,18)19/h1-8H,(H2,20,22,23,24,25) XBUASUBEROZIQU-UHFFFAOYSA-N 50573799 CHEMBL4875918 Dipeptidyl peptidase 1 >3000 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573799&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768823 471063944 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420548 CN1CCN(CC1)c1ccc(Nc2ncc(Cl)c(Nc3cccc(c3)C(F)(F)F)n2)cc1 InChI=1S/C22H22ClF3N6/c1-31-9-11-32(12-10-31)18-7-5-16(6-8-18)29-21-27-14-19(23)20(30-21)28-17-4-2-3-15(13-17)22(24,25)26/h2-8,13-14H,9-12H2,1H3,(H2,27,28,29,30) CJGXYTXDCLOCPM-UHFFFAOYSA-N 50573800 CHEMBL4862932 Dipeptidyl peptidase 1 1005 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573800&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768811 471063945 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420549 CN1CCN(CC1)c1ccc(Nc2ncc(Cl)c(Nc3cccc(c3)C(F)(F)F)n2)nc1 InChI=1S/C21H21ClF3N7/c1-31-7-9-32(10-8-31)16-5-6-18(26-12-16)29-20-27-13-17(22)19(30-20)28-15-4-2-3-14(11-15)21(23,24)25/h2-6,11-13H,7-10H2,1H3,(H2,26,27,28,29,30) JNAOGJWOQFVLOM-UHFFFAOYSA-N 50573801 CHEMBL4859234 Dipeptidyl peptidase 1 24 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573801&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768862 471063946 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420550 CN1CCN(CC1)c1ccc(Nc2ncc(Cl)c(Nc3cccc(c3)C(F)(F)F)n2)cn1 InChI=1S/C21H21ClF3N7/c1-31-7-9-32(10-8-31)18-6-5-16(12-26-18)29-20-27-13-17(22)19(30-20)28-15-4-2-3-14(11-15)21(23,24)25/h2-6,11-13H,7-10H2,1H3,(H2,27,28,29,30) YNGWEWBJFQRFCH-UHFFFAOYSA-N 50573802 CHEMBL4875913 Dipeptidyl peptidase 1 82 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573802 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573802&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768844 471063947 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420551 CN1CCN(CC1)c1ncc(Nc2ncc(Cl)c(Nc3cccc(c3)C(F)(F)F)n2)cn1 InChI=1S/C20H20ClF3N8/c1-31-5-7-32(8-6-31)19-26-10-15(11-27-19)29-18-25-12-16(21)17(30-18)28-14-4-2-3-13(9-14)20(22,23)24/h2-4,9-12H,5-8H2,1H3,(H2,25,28,29,30) HETZJTKUZBUOBT-UHFFFAOYSA-N 50573803 CHEMBL4862809 Dipeptidyl peptidase 1 144 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573803 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573803&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768814 471063948 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420552 CN1CCN(CC1)c1ccc(Nc2ncc(Cl)c(Nc3cccc(c3)C(F)(F)F)n2)nn1 InChI=1S/C20H20ClF3N8/c1-31-7-9-32(10-8-31)17-6-5-16(29-30-17)27-19-25-12-15(21)18(28-19)26-14-4-2-3-13(11-14)20(22,23)24/h2-6,11-12H,7-10H2,1H3,(H2,25,26,27,28,29) XYXQHAUYFPXZQW-UHFFFAOYSA-N 50573804 CHEMBL4850792 Dipeptidyl peptidase 1 120 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573804 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573804&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768850 471063949 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420553 CCN1CCN(CC1)c1ccc(Nc2ncc(Cl)c(Nc3cccc(c3)C(F)(F)F)n2)nc1 InChI=1S/C22H23ClF3N7/c1-2-32-8-10-33(11-9-32)17-6-7-19(27-13-17)30-21-28-14-18(23)20(31-21)29-16-5-3-4-15(12-16)22(24,25)26/h3-7,12-14H,2,8-11H2,1H3,(H2,27,28,29,30,31) ZIGDOWJPKOPVRE-UHFFFAOYSA-N 50573805 CHEMBL4852320 Dipeptidyl peptidase 1 33 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573805 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573805&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768848 471063950 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420554 CCCN1CCN(CC1)c1ccc(Nc2ncc(Cl)c(Nc3cccc(c3)C(F)(F)F)n2)nc1 InChI=1S/C23H25ClF3N7/c1-2-8-33-9-11-34(12-10-33)18-6-7-20(28-14-18)31-22-29-15-19(24)21(32-22)30-17-5-3-4-16(13-17)23(25,26)27/h3-7,13-15H,2,8-12H2,1H3,(H2,28,29,30,31,32) IGQCCPXSHBTJOW-UHFFFAOYSA-N 50573806 CHEMBL4853612 Dipeptidyl peptidase 1 76 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573806 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573806&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768870 471063951 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420555 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(cn3)N3CCN(CC3)C3CC3)ncc2Cl)c1 InChI=1S/C23H23ClF3N7/c24-19-14-29-22(32-21(19)30-16-3-1-2-15(12-16)23(25,26)27)31-20-7-6-18(13-28-20)34-10-8-33(9-11-34)17-4-5-17/h1-3,6-7,12-14,17H,4-5,8-11H2,(H2,28,29,30,31,32) FQBJTPXARACKIP-UHFFFAOYSA-N 50573807 CHEMBL4848848 Dipeptidyl peptidase 1 712 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573807&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 164618324 471063952 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420556 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(cn3)N3CCN4CCCCC4C3)ncc2Cl)c1 InChI=1S/C24H25ClF3N7/c25-20-14-30-23(33-22(20)31-17-5-3-4-16(12-17)24(26,27)28)32-21-8-7-18(13-29-21)35-11-10-34-9-2-1-6-19(34)15-35/h3-5,7-8,12-14,19H,1-2,6,9-11,15H2,(H2,29,30,31,32,33) QKDRVNVJLPIYKX-UHFFFAOYSA-N 50573808 CHEMBL4854078 Dipeptidyl peptidase 1 247 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573808 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573808&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 164615111 471063953 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420557 CC(=O)N1CCN(CC1)c1ccc(Nc2ncc(Cl)c(Nc3cccc(c3)C(F)(F)F)n2)nc1 InChI=1S/C22H21ClF3N7O/c1-14(34)32-7-9-33(10-8-32)17-5-6-19(27-12-17)30-21-28-13-18(23)20(31-21)29-16-4-2-3-15(11-16)22(24,25)26/h2-6,11-13H,7-10H2,1H3,(H2,27,28,29,30,31) YLTAJZAGZXAKKF-UHFFFAOYSA-N 50573809 CHEMBL4859374 Dipeptidyl peptidase 1 660 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573809&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 164616459 471063954 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420558 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(cn3)N3CCNCC3)ncc2Cl)c1 InChI=1S/C20H19ClF3N7/c21-16-12-27-19(29-17-5-4-15(11-26-17)31-8-6-25-7-9-31)30-18(16)28-14-3-1-2-13(10-14)20(22,23)24/h1-5,10-12,25H,6-9H2,(H2,26,27,28,29,30) XRNBLQBDZUJCOL-UHFFFAOYSA-N 50573811 CHEMBL4873553 Dipeptidyl peptidase 1 55 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573811&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 164622083 471063956 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420559 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(cn3)N3CCSCC3)ncc2Cl)c1 InChI=1S/C20H18ClF3N6S/c21-16-12-26-19(28-17-5-4-15(11-25-17)30-6-8-31-9-7-30)29-18(16)27-14-3-1-2-13(10-14)20(22,23)24/h1-5,10-12H,6-9H2,(H2,25,26,27,28,29) LZJJKANATVKZKL-UHFFFAOYSA-N 50573814 CHEMBL4850341 Dipeptidyl peptidase 1 >3000 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573814&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768842 471063959 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420560 NC1CCN(CC1)c1ccc(Nc2ncc(Cl)c(Nc3cccc(c3)C(F)(F)F)n2)nc1 InChI=1S/C21H21ClF3N7/c22-17-12-28-20(31-19(17)29-15-3-1-2-13(10-15)21(23,24)25)30-18-5-4-16(11-27-18)32-8-6-14(26)7-9-32/h1-5,10-12,14H,6-9,26H2,(H2,27,28,29,30,31) BWFNOCLZALFPLG-UHFFFAOYSA-N 50573815 CHEMBL4875426 Dipeptidyl peptidase 1 186 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573815 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573815&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768873 471063960 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420561 CN(C)C1CCN(CC1)c1ccc(Nc2ncc(Cl)c(Nc3cccc(c3)C(F)(F)F)n2)nc1 InChI=1S/C23H25ClF3N7/c1-33(2)17-8-10-34(11-9-17)18-6-7-20(28-13-18)31-22-29-14-19(24)21(32-22)30-16-5-3-4-15(12-16)23(25,26)27/h3-7,12-14,17H,8-11H2,1-2H3,(H2,28,29,30,31,32) PBJMGYJAKOSSSQ-UHFFFAOYSA-N 50573816 CHEMBL4869755 Dipeptidyl peptidase 1 44 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573816 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573816&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768828 471063961 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420562 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(cn3)-c3ccccc3)ncc2Cl)c1 InChI=1S/C22H15ClF3N5/c23-18-13-28-21(30-19-10-9-15(12-27-19)14-5-2-1-3-6-14)31-20(18)29-17-8-4-7-16(11-17)22(24,25)26/h1-13H,(H2,27,28,29,30,31) ICOKEPHBAONPHG-UHFFFAOYSA-N 50573818 CHEMBL4853461 Dipeptidyl peptidase 1 286 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573818 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573818&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768874 471063963 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420563 Nc1ccc(cc1)-c1ccc(Nc2ncc(Cl)c(Nc3cccc(c3)C(F)(F)F)n2)nc1 InChI=1S/C22H16ClF3N6/c23-18-12-29-21(32-20(18)30-17-3-1-2-15(10-17)22(24,25)26)31-19-9-6-14(11-28-19)13-4-7-16(27)8-5-13/h1-12H,27H2,(H2,28,29,30,31,32) ACTYGNXJGLFMRG-UHFFFAOYSA-N 50573819 CHEMBL4879107 Dipeptidyl peptidase 1 281 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573819&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768815 471063964 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420564 CN(C)c1ccc(cc1)-c1ccc(Nc2ncc(Cl)c(Nc3cccc(c3)C(F)(F)F)n2)nc1 InChI=1S/C24H20ClF3N6/c1-34(2)19-9-6-15(7-10-19)16-8-11-21(29-13-16)32-23-30-14-20(25)22(33-23)31-18-5-3-4-17(12-18)24(26,27)28/h3-14H,1-2H3,(H2,29,30,31,32,33) XXOZKOQBZDSJCB-UHFFFAOYSA-N 50573820 CHEMBL4867247 Dipeptidyl peptidase 1 114 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573820&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768826 471063965 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420565 Cn1cc(cn1)-c1ccc(Nc2ncc(Cl)c(Nc3cccc(c3)C(F)(F)F)n2)nc1 InChI=1S/C20H15ClF3N7/c1-31-11-13(9-27-31)12-5-6-17(25-8-12)29-19-26-10-16(21)18(30-19)28-15-4-2-3-14(7-15)20(22,23)24/h2-11H,1H3,(H2,25,26,28,29,30) YTXYIJYKTPPNAA-UHFFFAOYSA-N 50573821 CHEMBL4875086 Dipeptidyl peptidase 1 286 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573821&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 164628181 471063966 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420566 Cc1noc(C)c1-c1ccc(Nc2ncc(Cl)c(Nc3cccc(c3)C(F)(F)F)n2)nc1 InChI=1S/C21H16ClF3N6O/c1-11-18(12(2)32-31-11)13-6-7-17(26-9-13)29-20-27-10-16(22)19(30-20)28-15-5-3-4-14(8-15)21(23,24)25/h3-10H,1-2H3,(H2,26,27,28,29,30) UHQMOPPHCWDJBV-UHFFFAOYSA-N 50573822 CHEMBL4861328 Dipeptidyl peptidase 1 >3000 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573822&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768868 471063967 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420567 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2Cl)c1 InChI=1S/C20H13ClF3N5S/c21-16-10-26-19(28-17-5-4-12(9-25-17)13-6-7-30-11-13)29-18(16)27-15-3-1-2-14(8-15)20(22,23)24/h1-11H,(H2,25,26,27,28,29) WRTIVQWHCXIVQC-UHFFFAOYSA-N 50573824 CHEMBL4847055 Dipeptidyl peptidase 1 48 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573824&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768840 471063969 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420568 CN1CCN(CC1)c1ccc(Nc2ncc(F)c(Nc3cccc(c3)C(F)(F)F)n2)nc1 InChI=1S/C21H21F4N7/c1-31-7-9-32(10-8-31)16-5-6-18(26-12-16)29-20-27-13-17(22)19(30-20)28-15-4-2-3-14(11-15)21(23,24)25/h2-6,11-13H,7-10H2,1H3,(H2,26,27,28,29,30) VECHFXRWBBRITA-UHFFFAOYSA-N 50573825 CHEMBL4861702 Dipeptidyl peptidase 1 67 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573825&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768846 471063970 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420569 CN1CCN(CC1)c1ccc(Nc2ncc(C)c(Nc3cccc(c3)C(F)(F)F)n2)nc1 InChI=1S/C22H24F3N7/c1-15-13-27-21(30-20(15)28-17-5-3-4-16(12-17)22(23,24)25)29-19-7-6-18(14-26-19)32-10-8-31(2)9-11-32/h3-7,12-14H,8-11H2,1-2H3,(H2,26,27,28,29,30) RBBYYHZBGMYZJC-UHFFFAOYSA-N 50573826 CHEMBL4865601 Dipeptidyl peptidase 1 210 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573826&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768856 471063971 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420570 COc1cnc(Nc2ccc(cn2)N2CCN(C)CC2)nc1Nc1cccc(c1)C(F)(F)F InChI=1S/C22H24F3N7O/c1-31-8-10-32(11-9-31)17-6-7-19(26-13-17)29-21-27-14-18(33-2)20(30-21)28-16-5-3-4-15(12-16)22(23,24)25/h3-7,12-14H,8-11H2,1-2H3,(H2,26,27,28,29,30) CJLNZTBMZGIQQO-UHFFFAOYSA-N 50573827 CHEMBL4846401 Dipeptidyl peptidase 1 153 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573827&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 164609596 471063972 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420571 FC(F)(F)c1cccc(Nc2ccnc(Nc3ccc(cn3)-c3ccsc3)n2)c1 InChI=1S/C20H14F3N5S/c21-20(22,23)15-2-1-3-16(10-15)26-18-6-8-24-19(28-18)27-17-5-4-13(11-25-17)14-7-9-29-12-14/h1-12H,(H2,24,25,26,27,28) PKDJMOPRADKMKS-UHFFFAOYSA-N 50573828 CHEMBL4859540 Dipeptidyl peptidase 1 92 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573828&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768812 471063973 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420572 Fc1cnc(Nc2ccc(cn2)-c2ccsc2)nc1Nc1cccc(c1)C(F)(F)F InChI=1S/C20H13F4N5S/c21-16-10-26-19(28-17-5-4-12(9-25-17)13-6-7-30-11-13)29-18(16)27-15-3-1-2-14(8-15)20(22,23)24/h1-11H,(H2,25,26,27,28,29) KRNIWFJLEHEGRG-UHFFFAOYSA-N 50573829 CHEMBL4875307 Dipeptidyl peptidase 1 90 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573829&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768829 471063974 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420573 Cc1cnc(Nc2ccc(cn2)-c2ccsc2)nc1Nc1cccc(c1)C(F)(F)F InChI=1S/C21H16F3N5S/c1-13-10-26-20(28-18-6-5-14(11-25-18)15-7-8-30-12-15)29-19(13)27-17-4-2-3-16(9-17)21(22,23)24/h2-12H,1H3,(H2,25,26,27,28,29) OFOHMVCGHGFMDH-UHFFFAOYSA-N 50573830 CHEMBL4868834 Dipeptidyl peptidase 1 90 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573830&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768834 471063975 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420574 COc1cnc(Nc2ccc(cn2)-c2ccsc2)nc1Nc1cccc(c1)C(F)(F)F InChI=1S/C21H16F3N5OS/c1-30-17-11-26-20(28-18-6-5-13(10-25-18)14-7-8-31-12-14)29-19(17)27-16-4-2-3-15(9-16)21(22,23)24/h2-12H,1H3,(H2,25,26,27,28,29) BZPCXHXAPWYWEV-UHFFFAOYSA-N 50573831 CHEMBL4848242 Dipeptidyl peptidase 1 100 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573831&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768861 471063976 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420575 CN1CCN(CC1)c1ccc(Nc2ncc(Cl)c(Oc3cccc(c3)C(F)(F)F)n2)nc1 InChI=1S/C21H20ClF3N6O/c1-30-7-9-31(10-8-30)15-5-6-18(26-12-15)28-20-27-13-17(22)19(29-20)32-16-4-2-3-14(11-16)21(23,24)25/h2-6,11-13H,7-10H2,1H3,(H,26,27,28,29) MONPBWNFYUPTME-UHFFFAOYSA-N 50573832 CHEMBL4869853 Dipeptidyl peptidase 1 141 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573832 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573832&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 164625201 471063977 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420576 CN1CCN(CC1)c1ccc(Nc2ncc(Cl)c(Oc3cccc(c3)C(F)(F)F)n2)cc1 InChI=1S/C22H21ClF3N5O/c1-30-9-11-31(12-10-30)17-7-5-16(6-8-17)28-21-27-14-19(23)20(29-21)32-18-4-2-3-15(13-18)22(24,25)26/h2-8,13-14H,9-12H2,1H3,(H,27,28,29) ROMPEXMBODHHSH-UHFFFAOYSA-N 50573833 CHEMBL4858382 Dipeptidyl peptidase 1 77 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573833 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573833&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 164610943 471063978 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420577 Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H24N4O4/c1-27-19-12-17(7-8-20(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)21-14-25-9-2-10-30-21/h3-8,12,18,21,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,21-/m0/s1 AEXFXNFMSAAELR-RXVVDRJESA-N 50195235 CHEMBL3900409::US10287258, Example 2::US10669245, Example 2::US11117874, Example 2::US11655221, Example 2::US11680049, Example 2 Dipeptidyl peptidase 1 10 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195235&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253852 375977090 CHEMBL3900409 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420578 FC(F)(F)Oc1cccc(Nc2nc(Nc3ccccc3)ncc2Cl)c1 InChI=1S/C17H12ClF3N4O/c18-14-10-22-16(24-11-5-2-1-3-6-11)25-15(14)23-12-7-4-8-13(9-12)26-17(19,20)21/h1-10H,(H2,22,23,24,25) AJHZEYSQHXGBRL-UHFFFAOYSA-N 50573762 CHEMBL4847625 Dipeptidyl peptidase 1 1660 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573762 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573762&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768833 471063907 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420579 FC(F)(F)c1cccc(Nc2nc(Nc3ccccc3)ncc2Cl)c1 InChI=1S/C17H12ClF3N4/c18-14-10-22-16(24-12-6-2-1-3-7-12)25-15(14)23-13-8-4-5-11(9-13)17(19,20)21/h1-10H,(H2,22,23,24,25) NFXIWZBRMBJQQA-UHFFFAOYSA-N 50573769 CHEMBL4863126 Dipeptidyl peptidase 1 992 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573769 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573769&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768858 471063914 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420580 FC(F)(F)c1cccc(Nc2nc(NC3CCCCC3)ncc2Cl)c1 InChI=1S/C17H18ClF3N4/c18-14-10-22-16(24-12-6-2-1-3-7-12)25-15(14)23-13-8-4-5-11(9-13)17(19,20)21/h4-5,8-10,12H,1-3,6-7H2,(H2,22,23,24,25) DLNHNOUISPOGPK-UHFFFAOYSA-N 50573776 CHEMBL4845784 Dipeptidyl peptidase 1 >3000 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573776 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573776&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768810 471063921 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420581 FC(F)(F)c1cccc(Nc2nc(NCCCc3ccccc3)ncc2Cl)c1 InChI=1S/C20H18ClF3N4/c21-17-13-26-19(25-11-5-8-14-6-2-1-3-7-14)28-18(17)27-16-10-4-9-15(12-16)20(22,23)24/h1-4,6-7,9-10,12-13H,5,8,11H2,(H2,25,26,27,28) BDJBQDWXWDLZTM-UHFFFAOYSA-N 50573778 CHEMBL4872742 Dipeptidyl peptidase 1 >3000 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573778 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573778&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 164621600 471063923 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420582 Fc1ccc(Nc2ncc(Cl)c(Nc3cccc(c3)C(F)(F)F)n2)cc1 InChI=1S/C17H11ClF4N4/c18-14-9-23-16(25-12-6-4-11(19)5-7-12)26-15(14)24-13-3-1-2-10(8-13)17(20,21)22/h1-9H,(H2,23,24,25,26) UGBDWDUEHMHBDO-UHFFFAOYSA-N 50573784 CHEMBL4849283 Dipeptidyl peptidase 1 1225 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573784 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573784&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768813 471063929 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420583 FC(F)(F)c1cccc(Nc2nc(Nc3ccccn3)ncc2Cl)c1 InChI=1S/C16H11ClF3N5/c17-12-9-22-15(24-13-6-1-2-7-21-13)25-14(12)23-11-5-3-4-10(8-11)16(18,19)20/h1-9H,(H2,21,22,23,24,25) UYKZDUHNCAAXGK-UHFFFAOYSA-N 50573795 CHEMBL4864926 Dipeptidyl peptidase 1 244 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573795&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768819 471063940 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420584 FC(F)(F)c1cccc(Nc2nc(Nc3cccnc3)ncc2Cl)c1 InChI=1S/C16H11ClF3N5/c17-13-9-22-15(24-12-5-2-6-21-8-12)25-14(13)23-11-4-1-3-10(7-11)16(18,19)20/h1-9H,(H2,22,23,24,25) GESFFVXKERNGNK-UHFFFAOYSA-N 50573796 CHEMBL4876934 Dipeptidyl peptidase 1 515 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573796&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768836 471063941 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420585 FC(F)(F)c1cccc(Nc2nc(Nc3ccncc3)ncc2Cl)c1 InChI=1S/C16H11ClF3N5/c17-13-9-22-15(24-11-4-6-21-7-5-11)25-14(13)23-12-3-1-2-10(8-12)16(18,19)20/h1-9H,(H2,21,22,23,24,25) BSNSWGWISOBVIP-UHFFFAOYSA-N 50573797 CHEMBL4846716 Dipeptidyl peptidase 1 >3000 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573797&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768867 471063942 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420586 FC(F)(F)c1cccc(Nc2nc(Nc3cncnc3)ncc2Cl)c1 InChI=1S/C15H10ClF3N6/c16-12-7-22-14(24-11-5-20-8-21-6-11)25-13(12)23-10-3-1-2-9(4-10)15(17,18)19/h1-8H,(H2,22,23,24,25) FHUDSNATRGHUNK-UHFFFAOYSA-N 50573798 CHEMBL4876235 Dipeptidyl peptidase 1 >3000 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573798&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768827 471063943 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420587 FC(F)(F)c1cccc(Nc2nc(Nc3cccnn3)ncc2Cl)c1 InChI=1S/C15H10ClF3N6/c16-11-8-20-14(23-12-5-2-6-21-25-12)24-13(11)22-10-4-1-3-9(7-10)15(17,18)19/h1-8H,(H2,20,22,23,24,25) XBUASUBEROZIQU-UHFFFAOYSA-N 50573799 CHEMBL4875918 Dipeptidyl peptidase 1 2064 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573799&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768823 471063944 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420588 CN1CCN(CC1)c1ccc(Nc2ncc(Cl)c(Nc3cccc(c3)C(F)(F)F)n2)cc1 InChI=1S/C22H22ClF3N6/c1-31-9-11-32(12-10-31)18-7-5-16(6-8-18)29-21-27-14-19(23)20(30-21)28-17-4-2-3-15(13-17)22(24,25)26/h2-8,13-14H,9-12H2,1H3,(H2,27,28,29,30) CJGXYTXDCLOCPM-UHFFFAOYSA-N 50573800 CHEMBL4862932 Dipeptidyl peptidase 1 144 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573800&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768811 471063945 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420589 CN1CCN(CC1)c1ccc(Nc2ncc(Cl)c(Nc3cccc(c3)C(F)(F)F)n2)nc1 InChI=1S/C21H21ClF3N7/c1-31-7-9-32(10-8-31)16-5-6-18(26-12-16)29-20-27-13-17(22)19(30-20)28-15-4-2-3-14(11-15)21(23,24)25/h2-6,11-13H,7-10H2,1H3,(H2,26,27,28,29,30) JNAOGJWOQFVLOM-UHFFFAOYSA-N 50573801 CHEMBL4859234 Dipeptidyl peptidase 1 21 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573801&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768862 471063946 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420590 CN1CCN(CC1)c1ccc(Nc2ncc(Cl)c(Nc3cccc(c3)C(F)(F)F)n2)cn1 InChI=1S/C21H21ClF3N7/c1-31-7-9-32(10-8-31)18-6-5-16(12-26-18)29-20-27-13-17(22)19(30-20)28-15-4-2-3-14(11-15)21(23,24)25/h2-6,11-13H,7-10H2,1H3,(H2,27,28,29,30) YNGWEWBJFQRFCH-UHFFFAOYSA-N 50573802 CHEMBL4875913 Dipeptidyl peptidase 1 96 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573802 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573802&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768844 471063947 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420591 CN1CCN(CC1)c1ncc(Nc2ncc(Cl)c(Nc3cccc(c3)C(F)(F)F)n2)cn1 InChI=1S/C20H20ClF3N8/c1-31-5-7-32(8-6-31)19-26-10-15(11-27-19)29-18-25-12-16(21)17(30-18)28-14-4-2-3-13(9-14)20(22,23)24/h2-4,9-12H,5-8H2,1H3,(H2,25,28,29,30) HETZJTKUZBUOBT-UHFFFAOYSA-N 50573803 CHEMBL4862809 Dipeptidyl peptidase 1 329 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573803 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573803&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768814 471063948 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420592 CN1CCN(CC1)c1ccc(Nc2ncc(Cl)c(Nc3cccc(c3)C(F)(F)F)n2)nn1 InChI=1S/C20H20ClF3N8/c1-31-7-9-32(10-8-31)17-6-5-16(29-30-17)27-19-25-12-15(21)18(28-19)26-14-4-2-3-13(11-14)20(22,23)24/h2-6,11-12H,7-10H2,1H3,(H2,25,26,27,28,29) XYXQHAUYFPXZQW-UHFFFAOYSA-N 50573804 CHEMBL4850792 Dipeptidyl peptidase 1 173 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573804 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573804&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768850 471063949 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420593 CCN1CCN(CC1)c1ccc(Nc2ncc(Cl)c(Nc3cccc(c3)C(F)(F)F)n2)nc1 InChI=1S/C22H23ClF3N7/c1-2-32-8-10-33(11-9-32)17-6-7-19(27-13-17)30-21-28-14-18(23)20(31-21)29-16-5-3-4-15(12-16)22(24,25)26/h3-7,12-14H,2,8-11H2,1H3,(H2,27,28,29,30,31) ZIGDOWJPKOPVRE-UHFFFAOYSA-N 50573805 CHEMBL4852320 Dipeptidyl peptidase 1 41 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573805 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573805&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768848 471063950 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420594 CCCN1CCN(CC1)c1ccc(Nc2ncc(Cl)c(Nc3cccc(c3)C(F)(F)F)n2)nc1 InChI=1S/C23H25ClF3N7/c1-2-8-33-9-11-34(12-10-33)18-6-7-20(28-14-18)31-22-29-15-19(24)21(32-22)30-17-5-3-4-16(13-17)23(25,26)27/h3-7,13-15H,2,8-12H2,1H3,(H2,28,29,30,31,32) IGQCCPXSHBTJOW-UHFFFAOYSA-N 50573806 CHEMBL4853612 Dipeptidyl peptidase 1 112 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573806 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573806&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768870 471063951 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420595 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(cn3)N3CCN(CC3)C3CC3)ncc2Cl)c1 InChI=1S/C23H23ClF3N7/c24-19-14-29-22(32-21(19)30-16-3-1-2-15(12-16)23(25,26)27)31-20-7-6-18(13-28-20)34-10-8-33(9-11-34)17-4-5-17/h1-3,6-7,12-14,17H,4-5,8-11H2,(H2,28,29,30,31,32) FQBJTPXARACKIP-UHFFFAOYSA-N 50573807 CHEMBL4848848 Dipeptidyl peptidase 1 1120 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573807&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 164618324 471063952 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420596 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(cn3)N3CCN4CCCCC4C3)ncc2Cl)c1 InChI=1S/C24H25ClF3N7/c25-20-14-30-23(33-22(20)31-17-5-3-4-16(12-17)24(26,27)28)32-21-8-7-18(13-29-21)35-11-10-34-9-2-1-6-19(34)15-35/h3-5,7-8,12-14,19H,1-2,6,9-11,15H2,(H2,29,30,31,32,33) QKDRVNVJLPIYKX-UHFFFAOYSA-N 50573808 CHEMBL4854078 Dipeptidyl peptidase 1 195 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573808 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573808&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 164615111 471063953 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420597 CC(=O)N1CCN(CC1)c1ccc(Nc2ncc(Cl)c(Nc3cccc(c3)C(F)(F)F)n2)nc1 InChI=1S/C22H21ClF3N7O/c1-14(34)32-7-9-33(10-8-32)17-5-6-19(27-12-17)30-21-28-13-18(23)20(31-21)29-16-4-2-3-15(11-16)22(24,25)26/h2-6,11-13H,7-10H2,1H3,(H2,27,28,29,30,31) YLTAJZAGZXAKKF-UHFFFAOYSA-N 50573809 CHEMBL4859374 Dipeptidyl peptidase 1 520 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573809&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 164616459 471063954 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420598 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(cn3)N3CCNCC3)ncc2Cl)c1 InChI=1S/C20H19ClF3N7/c21-16-12-27-19(29-17-5-4-15(11-26-17)31-8-6-25-7-9-31)30-18(16)28-14-3-1-2-13(10-14)20(22,23)24/h1-5,10-12,25H,6-9H2,(H2,26,27,28,29,30) XRNBLQBDZUJCOL-UHFFFAOYSA-N 50573811 CHEMBL4873553 Dipeptidyl peptidase 1 88 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573811&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 164622083 471063956 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420599 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(cn3)N3CCSCC3)ncc2Cl)c1 InChI=1S/C20H18ClF3N6S/c21-16-12-26-19(28-17-5-4-15(11-25-17)30-6-8-31-9-7-30)29-18(16)27-14-3-1-2-13(10-14)20(22,23)24/h1-5,10-12H,6-9H2,(H2,25,26,27,28,29) LZJJKANATVKZKL-UHFFFAOYSA-N 50573814 CHEMBL4850341 Dipeptidyl peptidase 1 1482 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573814&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768842 471063959 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420600 NC1CCN(CC1)c1ccc(Nc2ncc(Cl)c(Nc3cccc(c3)C(F)(F)F)n2)nc1 InChI=1S/C21H21ClF3N7/c22-17-12-28-20(31-19(17)29-15-3-1-2-13(10-15)21(23,24)25)30-18-5-4-16(11-27-18)32-8-6-14(26)7-9-32/h1-5,10-12,14H,6-9,26H2,(H2,27,28,29,30,31) BWFNOCLZALFPLG-UHFFFAOYSA-N 50573815 CHEMBL4875426 Dipeptidyl peptidase 1 351 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573815 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573815&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768873 471063960 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420601 CN(C)C1CCN(CC1)c1ccc(Nc2ncc(Cl)c(Nc3cccc(c3)C(F)(F)F)n2)nc1 InChI=1S/C23H25ClF3N7/c1-33(2)17-8-10-34(11-9-17)18-6-7-20(28-13-18)31-22-29-14-19(24)21(32-22)30-16-5-3-4-15(12-16)23(25,26)27/h3-7,12-14,17H,8-11H2,1-2H3,(H2,28,29,30,31,32) PBJMGYJAKOSSSQ-UHFFFAOYSA-N 50573816 CHEMBL4869755 Dipeptidyl peptidase 1 28 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573816 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573816&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768828 471063961 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420602 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(cn3)-c3ccccc3)ncc2Cl)c1 InChI=1S/C22H15ClF3N5/c23-18-13-28-21(30-19-10-9-15(12-27-19)14-5-2-1-3-6-14)31-20(18)29-17-8-4-7-16(11-17)22(24,25)26/h1-13H,(H2,27,28,29,30,31) ICOKEPHBAONPHG-UHFFFAOYSA-N 50573818 CHEMBL4853461 Dipeptidyl peptidase 1 309 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573818 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573818&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768874 471063963 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420603 Nc1ccc(cc1)-c1ccc(Nc2ncc(Cl)c(Nc3cccc(c3)C(F)(F)F)n2)nc1 InChI=1S/C22H16ClF3N6/c23-18-12-29-21(32-20(18)30-17-3-1-2-15(10-17)22(24,25)26)31-19-9-6-14(11-28-19)13-4-7-16(27)8-5-13/h1-12H,27H2,(H2,28,29,30,31,32) ACTYGNXJGLFMRG-UHFFFAOYSA-N 50573819 CHEMBL4879107 Dipeptidyl peptidase 1 251 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573819&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768815 471063964 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420604 CN(C)c1ccc(cc1)-c1ccc(Nc2ncc(Cl)c(Nc3cccc(c3)C(F)(F)F)n2)nc1 InChI=1S/C24H20ClF3N6/c1-34(2)19-9-6-15(7-10-19)16-8-11-21(29-13-16)32-23-30-14-20(25)22(33-23)31-18-5-3-4-17(12-18)24(26,27)28/h3-14H,1-2H3,(H2,29,30,31,32,33) XXOZKOQBZDSJCB-UHFFFAOYSA-N 50573820 CHEMBL4867247 Dipeptidyl peptidase 1 142 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573820&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768826 471063965 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420605 Cn1cc(cn1)-c1ccc(Nc2ncc(Cl)c(Nc3cccc(c3)C(F)(F)F)n2)nc1 InChI=1S/C20H15ClF3N7/c1-31-11-13(9-27-31)12-5-6-17(25-8-12)29-19-26-10-16(21)18(30-19)28-15-4-2-3-14(7-15)20(22,23)24/h2-11H,1H3,(H2,25,26,28,29,30) YTXYIJYKTPPNAA-UHFFFAOYSA-N 50573821 CHEMBL4875086 Dipeptidyl peptidase 1 392 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573821&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 164628181 471063966 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420606 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2Cl)c1 InChI=1S/C20H13ClF3N5S/c21-16-10-26-19(28-17-5-4-12(9-25-17)13-6-7-30-11-13)29-18(16)27-15-3-1-2-14(8-15)20(22,23)24/h1-11H,(H2,25,26,27,28,29) WRTIVQWHCXIVQC-UHFFFAOYSA-N 50573824 CHEMBL4847055 Dipeptidyl peptidase 1 73 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573824&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768840 471063969 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420607 CN1CCN(CC1)c1ccc(Nc2ncc(F)c(Nc3cccc(c3)C(F)(F)F)n2)nc1 InChI=1S/C21H21F4N7/c1-31-7-9-32(10-8-31)16-5-6-18(26-12-16)29-20-27-13-17(22)19(30-20)28-15-4-2-3-14(11-15)21(23,24)25/h2-6,11-13H,7-10H2,1H3,(H2,26,27,28,29,30) VECHFXRWBBRITA-UHFFFAOYSA-N 50573825 CHEMBL4861702 Dipeptidyl peptidase 1 81 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573825&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768846 471063970 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420608 CN1CCN(CC1)c1ccc(Nc2ncc(C)c(Nc3cccc(c3)C(F)(F)F)n2)nc1 InChI=1S/C22H24F3N7/c1-15-13-27-21(30-20(15)28-17-5-3-4-16(12-17)22(23,24)25)29-19-7-6-18(14-26-19)32-10-8-31(2)9-11-32/h3-7,12-14H,8-11H2,1-2H3,(H2,26,27,28,29,30) RBBYYHZBGMYZJC-UHFFFAOYSA-N 50573826 CHEMBL4865601 Dipeptidyl peptidase 1 193 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573826&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768856 471063971 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420609 COc1cnc(Nc2ccc(cn2)N2CCN(C)CC2)nc1Nc1cccc(c1)C(F)(F)F InChI=1S/C22H24F3N7O/c1-31-8-10-32(11-9-31)17-6-7-19(26-13-17)29-21-27-14-18(33-2)20(30-21)28-16-5-3-4-15(12-16)22(23,24)25/h3-7,12-14H,8-11H2,1-2H3,(H2,26,27,28,29,30) CJLNZTBMZGIQQO-UHFFFAOYSA-N 50573827 CHEMBL4846401 Dipeptidyl peptidase 1 156 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573827&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 164609596 471063972 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420610 FC(F)(F)c1cccc(Nc2ccnc(Nc3ccc(cn3)-c3ccsc3)n2)c1 InChI=1S/C20H14F3N5S/c21-20(22,23)15-2-1-3-16(10-15)26-18-6-8-24-19(28-18)27-17-5-4-13(11-25-17)14-7-9-29-12-14/h1-12H,(H2,24,25,26,27,28) PKDJMOPRADKMKS-UHFFFAOYSA-N 50573828 CHEMBL4859540 Dipeptidyl peptidase 1 62 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573828&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768812 471063973 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420611 Fc1cnc(Nc2ccc(cn2)-c2ccsc2)nc1Nc1cccc(c1)C(F)(F)F InChI=1S/C20H13F4N5S/c21-16-10-26-19(28-17-5-4-12(9-25-17)13-6-7-30-11-13)29-18(16)27-15-3-1-2-14(8-15)20(22,23)24/h1-11H,(H2,25,26,27,28,29) KRNIWFJLEHEGRG-UHFFFAOYSA-N 50573829 CHEMBL4875307 Dipeptidyl peptidase 1 74 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573829&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768829 471063974 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420612 Cc1cnc(Nc2ccc(cn2)-c2ccsc2)nc1Nc1cccc(c1)C(F)(F)F InChI=1S/C21H16F3N5S/c1-13-10-26-20(28-18-6-5-14(11-25-18)15-7-8-30-12-15)29-19(13)27-17-4-2-3-16(9-17)21(22,23)24/h2-12H,1H3,(H2,25,26,27,28,29) OFOHMVCGHGFMDH-UHFFFAOYSA-N 50573830 CHEMBL4868834 Dipeptidyl peptidase 1 130 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573830&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768834 471063975 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420613 COc1cnc(Nc2ccc(cn2)-c2ccsc2)nc1Nc1cccc(c1)C(F)(F)F InChI=1S/C21H16F3N5OS/c1-30-17-11-26-20(28-18-6-5-13(10-25-18)14-7-8-31-12-14)29-19(17)27-16-4-2-3-15(9-16)21(22,23)24/h2-12H,1H3,(H2,25,26,27,28,29) BZPCXHXAPWYWEV-UHFFFAOYSA-N 50573831 CHEMBL4848242 Dipeptidyl peptidase 1 134 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573831&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768861 471063976 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420614 CN1CCN(CC1)c1ccc(Nc2ncc(Cl)c(Oc3cccc(c3)C(F)(F)F)n2)nc1 InChI=1S/C21H20ClF3N6O/c1-30-7-9-31(10-8-30)15-5-6-18(26-12-15)28-20-27-13-17(22)19(29-20)32-16-4-2-3-14(11-16)21(23,24)25/h2-6,11-13H,7-10H2,1H3,(H,26,27,28,29) MONPBWNFYUPTME-UHFFFAOYSA-N 50573832 CHEMBL4869853 Dipeptidyl peptidase 1 71 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573832 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573832&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 164625201 471063977 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420615 CN1CCN(CC1)c1ccc(Nc2ncc(Cl)c(Oc3cccc(c3)C(F)(F)F)n2)cc1 InChI=1S/C22H21ClF3N5O/c1-30-9-11-31(12-10-30)17-7-5-16(6-8-17)28-21-27-14-19(23)20(29-21)32-18-4-2-3-15(13-18)22(24,25)26/h2-8,13-14H,9-12H2,1H3,(H,27,28,29) ROMPEXMBODHHSH-UHFFFAOYSA-N 50573833 CHEMBL4858382 Dipeptidyl peptidase 1 128 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573833 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573833&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 164610943 471063978 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51420616 Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H24N4O4/c1-27-19-12-17(7-8-20(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)21-14-25-9-2-10-30-21/h3-8,12,18,21,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,21-/m0/s1 AEXFXNFMSAAELR-RXVVDRJESA-N 50195235 CHEMBL3900409::US10287258, Example 2::US10669245, Example 2::US11117874, Example 2::US11655221, Example 2::US11680049, Example 2 Dipeptidyl peptidase 1 15 ChEMBL 10.1021/acs.jmedchem.1c00104 10.7270/Q2QZ2FS7 34374541 Chen, X; Yan, Y; Zhang, Z; Zhang, F; Liu, M; Du, L; Zhang, H; Shen, X; Zhao, D; Shi, JB; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195235&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253852 375977090 CHEMBL3900409 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1285115 Fc1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C21H22FN3O2/c22-18-8-6-17(7-9-18)16-4-2-15(3-5-16)12-19(13-23)25-21(26)20-14-24-10-1-11-27-20/h2-9,19-20,24H,1,10-12,14H2,(H,25,26)/t19-,20-/m0/s1 PYXGGJVWIVBQRO-PMACEKPBSA-N 385072 (2S)-N-[(1S)-1-Cyano-2-(4'-fluorobiphenyl-4-yl)ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 32::US10669245, Example 32::US11117874, Example 32::US11655221, Example 32::US11667615, Example 32::US11680049, Example 32 Dipeptidyl peptidase 1 42.7 US Patent 10.7270/Q2FB56W4 US11673871 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385072&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253858 404854295 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1282403 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)[C@@H]1CNCCCO1 InChI=1S/C22H22N4O2/c23-13-17-4-8-19(9-5-17)18-6-2-16(3-7-18)12-20(14-24)26-22(27)21-15-25-10-1-11-28-21/h2-9,20-21,25H,1,10-12,15H2,(H,26,27)/t20-,21-/m0/s1 FCRODBUNBQJNPU-SFTDATJTSA-N 50195236 CHEMBL3927609::US10287258, Example 1::US10669245, Example 1::US11117874, Example 1::US11673871, Example 34::US11680049, Example 1 Dipeptidyl peptidase 1 35.5 US Patent 10.7270/Q2H99949 US11667615 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195236&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253857 375977091 CHEMBL3927609 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1282404 Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H24N4O4/c1-27-19-12-17(7-8-20(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)21-14-25-9-2-10-30-21/h3-8,12,18,21,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,21-/m0/s1 AEXFXNFMSAAELR-RXVVDRJESA-N 50195235 CHEMBL3900409::US10287258, Example 2::US10669245, Example 2::US11117874, Example 2::US11655221, Example 2::US11680049, Example 2 Dipeptidyl peptidase 1 4.47 US Patent 10.7270/Q2H99949 US11667615 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195235&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253852 375977090 CHEMBL3900409 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1282405 Cc1cc(cc2n(C)c(=O)oc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H26N4O4/c1-15-10-18(12-20-22(15)32-24(30)28(20)2)17-6-4-16(5-7-17)11-19(13-25)27-23(29)21-14-26-8-3-9-31-21/h4-7,10,12,19,21,26H,3,8-9,11,14H2,1-2H3,(H,27,29)/t19-,21-/m0/s1 WCWJGAFMGPMBQG-FPOVZHCZSA-N 50195240 CHEMBL3960432::US10287258, Example 3::US10669245, Example 3::US11117874, Example 3::US11655221, Example 3::US11680049, Example 3 Dipeptidyl peptidase 1 10.2 US Patent 10.7270/Q2H99949 US11667615 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195240&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253824 375977095 CHEMBL3960432 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1282406 CS(=O)(=O)Oc1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C22H25N3O5S/c1-31(27,28)30-20-5-2-4-18(13-20)17-8-6-16(7-9-17)12-19(14-23)25-22(26)21-15-24-10-3-11-29-21/h2,4-9,13,19,21,24H,3,10-12,15H2,1H3,(H,25,26)/t19-,21-/m0/s1 IRYUDRJLDSHZAO-FPOVZHCZSA-N 385044 4′-[(2S)-2-Cyano-2-{[(2S)-1,4-oxazepan-2-ylcarbonyl]amino}ethyl]biphenyl-3-yl methanesulfonate::US10287258, Example 4::US10669245, Example 4::US11117874, Example 4::US11667615, Example 4::US11680049, Example 4 Dipeptidyl peptidase 1 79.4 US Patent 10.7270/Q2H99949 US11667615 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385044&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253891 404854267 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1282407 Cc1noc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H24N4O3/c1-15-20-12-18(7-8-21(20)30-27-15)17-5-3-16(4-6-17)11-19(13-24)26-23(28)22-14-25-9-2-10-29-22/h3-8,12,19,22,25H,2,9-11,14H2,1H3,(H,26,28)/t19-,22-/m0/s1 QCTYSVBOKIUUFU-UGKGYDQZSA-N 604849 (2S)-N-{(1S)-1-Cyano-2-[4-(3-methyl-1,2-benzoxazol-5-yl)phenyl]ethyl}-1,4-oxazepane-2-carboxamide::US11667615, Example 5 Dipeptidyl peptidase 1 16.2 US Patent 10.7270/Q2H99949 US11667615 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=604849 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=604849&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253855 482597539 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1282408 FC(F)(F)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C22H22F3N3O2/c23-22(24,25)18-8-6-17(7-9-18)16-4-2-15(3-5-16)12-19(13-26)28-21(29)20-14-27-10-1-11-30-20/h2-9,19-20,27H,1,10-12,14H2,(H,28,29)/t19-,20-/m0/s1 USBDHHJQNTYSNJ-PMACEKPBSA-N 604850 (2S)-N-{(1S)-1-Cyano-2-[4′-(trifluoromethyl)biphenyl-4-yl]ethyl}-1,4-oxazepane-2-carboxamide::US11667615, Example 6 Dipeptidyl peptidase 1 36.3 US Patent 10.7270/Q2H99949 US11667615 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=604850 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=604850&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253859 482597540 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1282409 Fc1ccc(cc1F)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C21H21F2N3O2/c22-18-7-6-16(11-19(18)23)15-4-2-14(3-5-15)10-17(12-24)26-21(27)20-13-25-8-1-9-28-20/h2-7,11,17,20,25H,1,8-10,13H2,(H,26,27)/t17-,20-/m0/s1 HSWVIXGRFREZJG-PXNSSMCTSA-N 385047 (2S)-N-[(1S)-1-Cyano-2-(3',4'-difluorobiphenyl-4-yl)ethyl]-1,4-oxazepane-2- carboxamide::US10287258, Example 7::US10669245, Example 7::US11117874, Example 7::US11655221, Example 7::US11667615, Example 7::US11680049, Example 7 Dipeptidyl peptidase 1 69.2 US Patent 10.7270/Q2H99949 US11667615 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385047&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253829 404854270 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1282410 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(nc1)C#N)C#N)[C@@H]1CNCCCO1 InChI=1S/C21H21N5O2/c22-11-18-7-6-17(13-25-18)16-4-2-15(3-5-16)10-19(12-23)26-21(27)20-14-24-8-1-9-28-20/h2-7,13,19-20,24H,1,8-10,14H2,(H,26,27)/t19-,20-/m0/s1 UZXVZQQAOVNOKG-PMACEKPBSA-N 385048 (2S)-N-{(1S)-1-Cyano-2-[4-(6-cyanopyridin-3-yl)phenyl]ethyl}-1,4-oxazepane-2- carboxamide::US10287258, Example 8::US10669245, Example 8::US11117874, Example 8::US11655221, Example 8::US11667615, Example 8::US11680049, Example 8 Dipeptidyl peptidase 1 87.1 US Patent 10.7270/Q2H99949 US11667615 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385048&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253853 404854271 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1282411 CN1C(=O)CSc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H26N4O3S/c1-28-20-12-18(7-8-22(20)32-15-23(28)29)17-5-3-16(4-6-17)11-19(13-25)27-24(30)21-14-26-9-2-10-31-21/h3-8,12,19,21,26H,2,9-11,14-15H2,1H3,(H,27,30)/t19-,21-/m0/s1 NSLGCWMFHWURGT-FPOVZHCZSA-N 385049 (2S)-N-{(1S)-1-Cyano-2-[4-(4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzothiazin-6- yl)phenyl]ethyl}-1,4-oxazepane-2-carboxamide::US10287258, Example 9::US10669245, Example 9::US11117874, Example 9::US11655221, Example 9::US11667615, Example 9::US11680049, Example 9 Dipeptidyl peptidase 1 12.9 US Patent 10.7270/Q2H99949 US11667615 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385049&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253849 404854272 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1282412 CCn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H26N4O4/c1-2-28-20-13-18(8-9-21(20)32-24(28)30)17-6-4-16(5-7-17)12-19(14-25)27-23(29)22-15-26-10-3-11-31-22/h4-9,13,19,22,26H,2-3,10-12,15H2,1H3,(H,27,29)/t19-,22-/m0/s1 HZZYFVOLMKQYKP-UGKGYDQZSA-N 604854 (2S)-N-{(1S)-1-Cyano-2-[4-(3-ethyl-7-methyl-2-oxo-2,3-dihydro-1,3-benzoxazo1-5-yl)phenyl]ethyl}-1,4-oxazepane-2-carboxamide::US11667615, Example 10::US11667615, Example 16::US11680049, Example 16 Dipeptidyl peptidase 1 21.4 US Patent 10.7270/Q2H99949 US11667615 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=604854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=604854&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253883 482597541 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1282413 CC(C)(O)Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C26H30N4O5/c1-26(2,33)16-30-21-13-19(8-9-22(21)35-25(30)32)18-6-4-17(5-7-18)12-20(14-27)29-24(31)23-15-28-10-3-11-34-23/h4-9,13,20,23,28,33H,3,10-12,15-16H2,1-2H3,(H,29,31)/t20-,23-/m0/s1 LRDOUIXCGZNESR-REWPJTCUSA-N 385051 (2S)-N-[(1S)-1-Cyano-2-{4-[3-(2-hydroxy-2-methylpropyl)-2-oxo-2,3-dihydro-1,3- benzoxazol-5-yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 11::US10669245, Example 11::US11117874, Example 11::US11655221, Example 11::US11667615, Example 11::US11680049, Example 11 Dipeptidyl peptidase 1 89.1 US Patent 10.7270/Q2H99949 US11667615 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385051&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253819 404854274 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1282414 FC(F)Cn1c2cc(cc(F)c2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H23F3N4O4/c25-18-9-16(10-19-22(18)35-24(33)31(19)13-21(26)27)15-4-2-14(3-5-15)8-17(11-28)30-23(32)20-12-29-6-1-7-34-20/h2-5,9-10,17,20-21,29H,1,6-8,12-13H2,(H,30,32)/t17-,20-/m0/s1 PVRGXPYTNXSTMU-PXNSSMCTSA-N 385052 (2S)-N-[(1S)-1-Cyano-2-{4-[3-(2,2-difluoroethyl)-7-fluoro-2-oxo-2,3-dihydro-1,3- benzoxazol-5-yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 12::US10669245, Example 12::US11117874, Example 12::US11655221, Example 12::US11667615, Example 12::US11680049, Example 12 Dipeptidyl peptidase 1 10.0 US Patent 10.7270/Q2H99949 US11667615 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385052&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253812 404854275 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1282415 CN(C)CCn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C26H31N5O4/c1-30(2)11-12-31-22-15-20(8-9-23(22)35-26(31)33)19-6-4-18(5-7-19)14-21(16-27)29-25(32)24-17-28-10-3-13-34-24/h4-9,15,21,24,28H,3,10-14,17H2,1-2H3,(H,29,32)/t21-,24-/m0/s1 BVHRFMZXVRJZAF-URXFXBBRSA-N 385053 (2S)-N-[(1S)-1-Cyano-2-(4-{3-[2-(dimethylamino)ethyl]-2-oxo-2,3-dihydro-1,3- benzoxazol-5-yl}pheny)ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 13::US10669245, Example 13::US11117874, Example 13::US11655221, Example 13::US11667615, Example 13::US11680049, Example 13 Dipeptidyl peptidase 1 7.24 US Patent 10.7270/Q2H99949 US11667615 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385053&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253865 404854276 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1282416 CN1C(=O)C(F)(F)c2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H24F2N4O3/c1-30-20-12-17(7-8-19(20)24(25,26)23(30)32)16-5-3-15(4-6-16)11-18(13-27)29-22(31)21-14-28-9-2-10-33-21/h3-8,12,18,21,28H,2,9-11,14H2,1H3,(H,29,31)/t18-,21-/m0/s1 SABYNPLHFAPZQF-RXVVDRJESA-N 604858 (2S)-N-{(1S)-1-Cyano-2-[4-(3,3-difluoro-1-methyl-2-oxo-2,3-dihydro-1H-indol-6-yl)phenyl]ethyl}-1,4-oxazepane-2-carboxamide::US11667615, Example 14 Dipeptidyl peptidase 1 16.6 US Patent 10.7270/Q2H99949 US11667615 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=604858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=604858&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253811 482597542 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1282417 Cn1c2cc(cc(F)c2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H23FN4O4/c1-28-19-11-16(10-18(24)21(19)32-23(28)30)15-5-3-14(4-6-15)9-17(12-25)27-22(29)20-13-26-7-2-8-31-20/h3-6,10-11,17,20,26H,2,7-9,13H2,1H3,(H,27,29)/t17-,20-/m0/s1 IVHOZTBKWBUDMJ-PXNSSMCTSA-N 385055 (2S)-N-{(1S)-1-Cyano-2-[4-(7-fluoro-3-methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-5- yl)phenyl]ethyl}-1,4-oxazepane-2-carboxamide::US10287258, Example 15::US10669245, Example 15::US11117874, Example 15::US11655221, Example 15::US11667615, Example 15::US11680049, Example 15 Dipeptidyl peptidase 1 5.13 US Patent 10.7270/Q2H99949 US11667615 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385055&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253861 404854278 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1282418 CCn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H26N4O4/c1-2-28-20-13-18(8-9-21(20)32-24(28)30)17-6-4-16(5-7-17)12-19(14-25)27-23(29)22-15-26-10-3-11-31-22/h4-9,13,19,22,26H,2-3,10-12,15H2,1H3,(H,27,29)/t19-,22-/m0/s1 HZZYFVOLMKQYKP-UGKGYDQZSA-N 604854 (2S)-N-{(1S)-1-Cyano-2-[4-(3-ethyl-7-methyl-2-oxo-2,3-dihydro-1,3-benzoxazo1-5-yl)phenyl]ethyl}-1,4-oxazepane-2-carboxamide::US11667615, Example 10::US11667615, Example 16::US11680049, Example 16 Dipeptidyl peptidase 1 5.75 US Patent 10.7270/Q2H99949 US11667615 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=604854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=604854&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253883 482597541 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1282419 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2oc(=O)n(CC3CC3)c2c1)C#N)[C@@H]1CNCCCO1 InChI=1S/C26H28N4O4/c27-14-21(29-25(31)24-15-28-10-1-11-33-24)12-17-4-6-19(7-5-17)20-8-9-23-22(13-20)30(26(32)34-23)16-18-2-3-18/h4-9,13,18,21,24,28H,1-3,10-12,15-16H2,(H,29,31)/t21-,24-/m0/s1 WJXGZWWSCFPECN-URXFXBBRSA-N 385057 (2S)-N-[(1S)-1-Cyano-2-{4-[3-(cyclopropylmethyl)-2-oxo-2,3-dihydro-1,3-benzoxazol- 5-yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 17::US10669245, Example 17::US11117874, Example 17::US11655221, Example 17::US11667615, Example 17::US11680049, Example 17 Dipeptidyl peptidase 1 6.31 US Patent 10.7270/Q2H99949 US11667615 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385057&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253827 404854280 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1282420 COCCn1c2cc(ccc2sc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C25H28N4O4S/c1-32-12-10-29-21-14-19(7-8-23(21)34-25(29)31)18-5-3-17(4-6-18)13-20(15-26)28-24(30)22-16-27-9-2-11-33-22/h3-8,14,20,22,27H,2,9-13,16H2,1H3,(H,28,30)/t20-,22-/m0/s1 GRJJVLYWMJAVMA-UNMCSNQZSA-N 385058 (2S)-N-[(1S)-1-Cyano-2-{4-[3-(2-methoxyethyl)-2-oxo-2,3-dihydro-1,3-benzothiazol- 5-yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 18::US10669245, Example 18::US11117874, Example 18::US11655221, Example 18::US11667615, Example 18::US11680049, Example 18 Dipeptidyl peptidase 1 3.16 US Patent 10.7270/Q2H99949 US11667615 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385058&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253842 404854281 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1282421 CC(C)n1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C25H28N4O4/c1-16(2)29-21-13-19(8-9-22(21)33-25(29)31)18-6-4-17(5-7-18)12-20(14-26)28-24(30)23-15-27-10-3-11-32-23/h4-9,13,16,20,23,27H,3,10-12,15H2,1-2H3,(H,28,30)/t20-,23-/m0/s1 WOBKXJRTDASPHQ-REWPJTCUSA-N 385059 (2S)-N- [(1S)-1-Cyano-2-{4-[2-oxo-3-(propan-2-yl)-2,3-dihydro-1,3-benzoxazol-5- yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 19::US10669245, Example 19::US11117874, Example 19::US11655221, Example 19::US11667615, Example 19::US11680049, Example 19 Dipeptidyl peptidase 1 14.5 US Patent 10.7270/Q2H99949 US11667615 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385059&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253878 404854282 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1282422 CN1C(=O)COc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H26N4O4/c1-28-20-12-18(7-8-21(20)32-15-23(28)29)17-5-3-16(4-6-17)11-19(13-25)27-24(30)22-14-26-9-2-10-31-22/h3-8,12,19,22,26H,2,9-11,14-15H2,1H3,(H,27,30)/t19-,22-/m0/s1 QKDQSHLZLZUQOA-UGKGYDQZSA-N 604864 (2S)-N-[(1S)-1-Cyano-2-[4-(4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)phenyl]ethyl}-1,4-oxazepane-2-carboxamide::US11667615, Example 20 Dipeptidyl peptidase 1 12.6 US Patent 10.7270/Q2H99949 US11667615 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=604864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=604864&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253870 482597543 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1282423 COCCn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C25H28N4O5/c1-32-12-10-29-21-14-19(7-8-22(21)34-25(29)31)18-5-3-17(4-6-18)13-20(15-26)28-24(30)23-16-27-9-2-11-33-23/h3-8,14,20,23,27H,2,9-13,16H2,1H3,(H,28,30)/t20-,23-/m0/s1 JUXOTDAODWSCQS-REWPJTCUSA-N 385061 (2S)-N-[(1S)-1-Cyano-2-{4-[3-(2-methoxyethyl)-2-oxo-2,3-dihydro-1,3-benzoxazol-5- yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 21::US10669245, Example 21::US11117874, Example 21::US11655221, Example 21::US11667615, Example 21::US11680049, Example 21 Dipeptidyl peptidase 1 8.13 US Patent 10.7270/Q2H99949 US11667615 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385061&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253879 404854284 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1282424 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(s1)C#N)C#N)[C@@H]1CNCCCO1 InChI=1S/C20H20N4O2S/c21-11-16(24-20(25)18-13-23-8-1-9-26-18)10-14-2-4-15(5-3-14)19-7-6-17(12-22)27-19/h2-7,16,18,23H,1,8-10,13H2,(H,24,25)/t16-,18-/m0/s1 AYKAKRZDQIFHMD-WMZOPIPTSA-N 385062 (2S)-N-{(1S)-1-Cyano-2-[4-(5-cyanothiophen-2-yl)phenyl]ethyl}-1,4-oxazepane-2- carboxamide::US10287258, Example 22::US10669245, Example 22::US11117874, Example 22::US11655221, Example 22::US11667615, Example 22::US11680049, Example 22 Dipeptidyl peptidase 1 19.5 US Patent 10.7270/Q2H99949 US11667615 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385062&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253837 404854285 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1282425 NC(=O)c1ccc(cc1F)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C22H23FN4O3/c23-19-11-16(6-7-18(19)21(25)28)15-4-2-14(3-5-15)10-17(12-24)27-22(29)20-13-26-8-1-9-30-20/h2-7,11,17,20,26H,1,8-10,13H2,(H2,25,28)(H,27,29)/t17-,20-/m0/s1 GCGGEFOSHQPZEX-PXNSSMCTSA-N 385063 (2S)-N-[(1S)-2-(4'-Carbamoy1-3'-fluorobiphenyl-4-yl)-1-cyanoethyl]-1,4-oxazepane-2- carboxamide::US10287258, Example 23::US10669245, Example 23::US11117874, Example 23::US11655221, Example 23::US11667615, Example 23::US11680049, Example 23 Dipeptidyl peptidase 1 67.6 US Patent 10.7270/Q2H99949 US11667615 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385063&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253894 404854286 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1282426 Cn1c2cc(ccc2ccc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C25H26N4O3/c1-29-22-14-20(8-7-19(22)9-10-24(29)30)18-5-3-17(4-6-18)13-21(15-26)28-25(31)23-16-27-11-2-12-32-23/h3-10,14,21,23,27H,2,11-13,16H2,1H3,(H,28,31)/t21-,23-/m0/s1 BQIZWZAQEICNDG-GMAHTHKFSA-N 604868 (2S)-N-[(1S)-1-Cyano-2-[4-(1-methyl-2-oxo-1,2-dihydroquinolin-7-yl)phenyl]ethyl}-1,4-oxazepane-2-carboxamide::US11667615, Example 24 Dipeptidyl peptidase 1 13.8 US Patent 10.7270/Q2H99949 US11667615 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=604868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=604868&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253851 482597544 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1282427 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2oc(=O)n(CC3CCOCC3)c2c1)C#N)[C@@H]1CNCCCO1 InChI=1S/C28H32N4O5/c29-16-23(31-27(33)26-17-30-10-1-11-36-26)14-19-2-4-21(5-3-19)22-6-7-25-24(15-22)32(28(34)37-25)18-20-8-12-35-13-9-20/h2-7,15,20,23,26,30H,1,8-14,17-18H2,(H,31,33)/t23-,26-/m0/s1 KFOHIWSKADTAQW-OZXSUGGESA-N 385065 (2S)-N-[(1S)-1-Cyano-2-{4-[2-oxo-3-(tetrahydro-2H-pyran-4-ylmethyl)-2,3-dihydro- 1,3-benzoxazol-5-yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 25::US10669245, Example 25::US11117874, Example 25::US11655221, Example 25::US11667615, Example 25::US11680049, Example 25 Dipeptidyl peptidase 1 10.7 US Patent 10.7270/Q2H99949 US11667615 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385065&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253876 404854288 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1282428 Cn1c2cc(cc(Cl)c2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H23ClN4O4/c1-28-19-11-16(10-18(24)21(19)32-23(28)30)15-5-3-14(4-6-15)9-17(12-25)27-22(29)20-13-26-7-2-8-31-20/h3-6,10-11,17,20,26H,2,7-9,13H2,1H3,(H,27,29)/t17-,20-/m0/s1 KTGYWWMCWUTXTI-PXNSSMCTSA-N 385066 (2S)-N-{(1S)-2-[4-(7-Chloro-3-methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)phenyl]- 1-cyanoethyl}-1,4-oxazepane-2-carboxamide::US10287258, Example 26::US10669245, Example 26::US11117874, Example 26::US11655221, Example 26::US11667615, Example 26::US11680049, Example 26 Dipeptidyl peptidase 1 13.5 US Patent 10.7270/Q2H99949 US11667615 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385066&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253874 404854289 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1282429 FC(F)Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H24F2N4O4/c25-22(26)14-30-19-11-17(6-7-20(19)34-24(30)32)16-4-2-15(3-5-16)10-18(12-27)29-23(31)21-13-28-8-1-9-33-21/h2-7,11,18,21-22,28H,1,8-10,13-14H2,(H,29,31)/t18-,21-/m0/s1 ANPJTTUBCRFBKA-RXVVDRJESA-N 604871 (2S)-N-[(1S)-1-Cyano-2-{4-[3-(2,2-difluoroethyl)-2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US11667615, Example 27 Dipeptidyl peptidase 1 6.61 US Patent 10.7270/Q2H99949 US11667615 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=604871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=604871&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253888 482597545 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1282430 FC(F)Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H24F2N4O4/c25-22(26)14-30-19-11-17(6-7-20(19)34-24(30)32)16-4-2-15(3-5-16)10-18(12-27)29-23(31)21-13-28-8-1-9-33-21/h2-7,11,18,21-22,28H,1,8-10,13-14H2,(H,29,31)/t18-,21-/m0/s1 ANPJTTUBCRFBKA-RXVVDRJESA-N 604871 (2S)-N-[(1S)-1-Cyano-2-{4-[3-(2,2-difluoroethyl)-2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US11667615, Example 27 Dipeptidyl peptidase 1 8.13 US Patent 10.7270/Q2H99949 US11667615 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=604871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=604871&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253888 482597545 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1282431 FC(F)(F)Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H23F3N4O4/c25-24(26,27)14-31-19-11-17(6-7-20(19)35-23(31)33)16-4-2-15(3-5-16)10-18(12-28)30-22(32)21-13-29-8-1-9-34-21/h2-7,11,18,21,29H,1,8-10,13-14H2,(H,30,32)/t18-,21-/m0/s1 KAGSLWGZQVTFPB-RXVVDRJESA-N 385068 (2S)-N-[(1S)-1-Cyano-2-{4-[2-oxo-3-(2,2,2-trifluoroethyl)-2,3-dihydro-1,3- benzoxazol-5-yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 28::US10669245, Example 28::US11117874, Example 28::US11655221, Example 28::US11667615, Example 28::US11680049, Example 28 Dipeptidyl peptidase 1 8.13 US Patent 10.7270/Q2H99949 US11667615 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385068&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253867 404854291 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1282432 Cn1c2cc(ccc2sc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H24N4O3S/c1-27-19-12-17(7-8-21(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)20-14-25-9-2-10-30-20/h3-8,12,18,20,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,20-/m0/s1 DRQDONWWFWYTII-ICSRJNTNSA-N 604873 (2S)-N-[(1S)-1-Cyano-2-[4-(3-methyl-2-oxo-2,3-dihydro-1,3-benzothiazol-5-yl)phenyl]ethyl}-1,4-oxazepane-2-carboxamide::US11667615, Example 29 Dipeptidyl peptidase 1 2.40 US Patent 10.7270/Q2H99949 US11667615 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=604873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=604873&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91826235 482597546 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1282433 CS(=O)(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C22H25N3O4S/c1-30(27,28)20-9-7-18(8-10-20)17-5-3-16(4-6-17)13-19(14-23)25-22(26)21-15-24-11-2-12-29-21/h3-10,19,21,24H,2,11-13,15H2,1H3,(H,25,26)/t19-,21-/m0/s1 UBRDXNDHEGQOTI-FPOVZHCZSA-N 385070 (2S)-N-{(1S)-1-Cyano-2-[4'-(methylsulfonyl)bipheny1-4-yl]ethyl}-1,4-oxazepane-2- carboxamide::US10287258, Example 30::US10669245, Example 30::US11117874, Example 30::US11655221, Example 30::US11667615, Example 30::US11680049, Example 30 Dipeptidyl peptidase 1 37.2 US Patent 10.7270/Q2H99949 US11667615 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385070&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253895 404854293 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1282434 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N1CCC1)C#N)[C@@H]1CNCCCO1 InChI=1S/C24H28N4O4S/c25-16-21(27-24(29)23-17-26-11-1-14-32-23)15-18-3-5-19(6-4-18)20-7-9-22(10-8-20)33(30,31)28-12-2-13-28/h3-10,21,23,26H,1-2,11-15,17H2,(H,27,29)/t21-,23-/m0/s1 CBWWXOUBSQCMHB-GMAHTHKFSA-N 385071 (2S)-N-{(1S)-2-[4'-(Azetidin-1-ylsulfonyl)biphenyl-4-yl]-1-cyanoethyl}-1,4-oxazepane- 2-carboxamide::US10287258, Example 31::US10669245, Example 31::US11117874, Example 31::US11655221, Example 31::US11667615, Example 31::US11680049, Example 31 Dipeptidyl peptidase 1 21.4 US Patent 10.7270/Q2H99949 US11667615 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385071&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253890 404854294 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1282435 Fc1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C21H22FN3O2/c22-18-8-6-17(7-9-18)16-4-2-15(3-5-16)12-19(13-23)25-21(26)20-14-24-10-1-11-27-20/h2-9,19-20,24H,1,10-12,14H2,(H,25,26)/t19-,20-/m0/s1 PYXGGJVWIVBQRO-PMACEKPBSA-N 385072 (2S)-N-[(1S)-1-Cyano-2-(4'-fluorobiphenyl-4-yl)ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 32::US10669245, Example 32::US11117874, Example 32::US11655221, Example 32::US11667615, Example 32::US11680049, Example 32 Dipeptidyl peptidase 1 42.7 US Patent 10.7270/Q2H99949 US11667615 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385072&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253858 404854295 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1282436 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2scnc2c1)C#N)[C@@H]1CNCCCO1 InChI=1S/C22H22N4O2S/c23-12-18(26-22(27)20-13-24-8-1-9-28-20)10-15-2-4-16(5-3-15)17-6-7-21-19(11-17)25-14-29-21/h2-7,11,14,18,20,24H,1,8-10,13H2,(H,26,27)/t18-,20-/m0/s1 MUTKXUKCDAFWLB-ICSRJNTNSA-N 604877 (2S)-N-{(1S)-2-[4-(1,3-Benzothiazol-5-yl)phenyl]-1-cyanoethyl}-1,4-oxazepane-2-carboxamide::US11667615, Example 33 Dipeptidyl peptidase 1 61.7 US Patent 10.7270/Q2H99949 US11667615 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=604877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=604877&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253877 482597547 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1282437 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)C1CNCCCO1 InChI=1S/C22H22N4O2/c23-13-17-4-8-19(9-5-17)18-6-2-16(3-7-18)12-20(14-24)26-22(27)21-15-25-10-1-11-28-21/h2-9,20-21,25H,1,10-12,15H2,(H,26,27)/t20-,21?/m0/s1 FCRODBUNBQJNPU-BGERDNNASA-N 385074 US10287258, Example 34::US10669245, Example 34::US11117874, Example 34::US11667615, Example 34::US11680049, Example 34 Dipeptidyl peptidase 1 60.3 US Patent 10.7270/Q2H99949 US11667615 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385074&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118260121 404854297 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1282438 CN1C(=O)CNc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H27N5O3/c1-29-21-12-18(7-8-20(21)27-15-23(29)30)17-5-3-16(4-6-17)11-19(13-25)28-24(31)22-14-26-9-2-10-32-22/h3-8,12,19,22,26-27H,2,9-11,14-15H2,1H3,(H,28,31)/t19-,22-/m0/s1 CPBDCTBYFQTDMV-UGKGYDQZSA-N 385075 US10287258, Example 35::US10669245, Example 35::US11117874, Example 35::US11673871, Example 35::US11680049, Example 35 Dipeptidyl peptidase 1 24.5 US Patent 10.7270/Q2H99949 US11667615 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385075&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253822 404854298 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1282439 CC[C@H](NC(=O)[C@@H]1CNCCCO1)\C=C\C(=O)N1CCc2ccccc12 InChI=1S/C20H27N3O3/c1-2-16(22-20(25)18-14-21-11-5-13-26-18)8-9-19(24)23-12-10-15-6-3-4-7-17(15)23/h3-4,6-9,16,18,21H,2,5,10-14H2,1H3,(H,22,25)/b9-8+/t16-,18-/m0/s1 OHNHQTNQBQMALV-LFGVRAQPSA-N 385076 BDBM445984::US10287258, Example 36::US11667615, Example 36::US11680049, Example 36 Dipeptidyl peptidase 1 5.01 US Patent 10.7270/Q2H99949 US11667615 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385076&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 144891673 404854299 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1282440 CC(C)C[C@H](NC(=O)[C@@H]1CNCCCO1)\C=C\C(=O)N1CCc2ccccc12 InChI=1S/C22H31N3O3/c1-16(2)14-18(24-22(27)20-15-23-11-5-13-28-20)8-9-21(26)25-12-10-17-6-3-4-7-19(17)25/h3-4,6-9,16,18,20,23H,5,10-15H2,1-2H3,(H,24,27)/b9-8+/t18-,20+/m1/s1 PXFMGAFAIVURSO-ZZHWGSSASA-N 385077 BDBM445985::US10287258, Example 37::US11667615, Example 37::US11680049, Example 37 Dipeptidyl peptidase 1 5.25 US Patent 10.7270/Q2H99949 US11667615 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385077&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 144891689 404854300 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1280608 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)[C@@H]1CNCCCO1 InChI=1S/C22H22N4O2/c23-13-17-4-8-19(9-5-17)18-6-2-16(3-7-18)12-20(14-24)26-22(27)21-15-25-10-1-11-28-21/h2-9,20-21,25H,1,10-12,15H2,(H,26,27)/t20-,21-/m0/s1 FCRODBUNBQJNPU-SFTDATJTSA-N 50195236 CHEMBL3927609::US10287258, Example 1::US10669245, Example 1::US11117874, Example 1::US11673871, Example 34::US11680049, Example 1 Dipeptidyl peptidase 1 35.5 US Patent 10.7270/Q2ZG6X5T US11655221 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195236&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253857 375977091 CHEMBL3927609 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1280609 Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H24N4O4/c1-27-19-12-17(7-8-20(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)21-14-25-9-2-10-30-21/h3-8,12,18,21,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,21-/m0/s1 AEXFXNFMSAAELR-RXVVDRJESA-N 50195235 CHEMBL3900409::US10287258, Example 2::US10669245, Example 2::US11117874, Example 2::US11655221, Example 2::US11680049, Example 2 Dipeptidyl peptidase 1 4.47 US Patent 10.7270/Q2ZG6X5T US11655221 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195235&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253852 375977090 CHEMBL3900409 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1280610 Cc1cc(cc2n(C)c(=O)oc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H26N4O4/c1-15-10-18(12-20-22(15)32-24(30)28(20)2)17-6-4-16(5-7-17)11-19(13-25)27-23(29)21-14-26-8-3-9-31-21/h4-7,10,12,19,21,26H,3,8-9,11,14H2,1-2H3,(H,27,29)/t19-,21-/m0/s1 WCWJGAFMGPMBQG-FPOVZHCZSA-N 50195240 CHEMBL3960432::US10287258, Example 3::US10669245, Example 3::US11117874, Example 3::US11655221, Example 3::US11680049, Example 3 Dipeptidyl peptidase 1 10.2 US Patent 10.7270/Q2ZG6X5T US11655221 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195240&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253824 375977095 CHEMBL3960432 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1280611 [O-]S(=O)(=O)Cc1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C22H25N3O5S/c23-13-20(25-22(26)21-14-24-9-2-10-30-21)12-16-5-7-18(8-6-16)19-4-1-3-17(11-19)15-31(27,28)29/h1,3-8,11,20-21,24H,2,9-10,12,14-15H2,(H,25,26)(H,27,28,29)/p-1/t20-,21-/m0/s1 XNVMYPLWDXXYKR-SFTDATJTSA-M 603888 4'-[(2S)-2-Cyano-2-{[(2S)-1,4-oxazepan-2-ylcarbonyl]amino}ethyl]biphenyl-3-ylmethanesulfonate::US11655221, Example 4 Dipeptidyl peptidase 1 79.4 US Patent 10.7270/Q2ZG6X5T US11655221 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=603888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=603888&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168430304 482596622 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1280612 Cc1noc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H24N4O3/c1-15-20-12-18(7-8-21(20)30-27-15)17-5-3-16(4-6-17)11-19(13-24)26-23(28)22-14-25-9-2-10-29-22/h3-8,12,19,22,25H,2,9-11,14H2,1H3,(H,26,28)/t19-,22-/m0/s1 QCTYSVBOKIUUFU-UGKGYDQZSA-N 50195245 CHEMBL3972158::US10287258, Example 5::US10669245, Example 5::US11117874, Example 5::US11655221, Example 5::US11680049, Example 5 Dipeptidyl peptidase 1 16.2 US Patent 10.7270/Q2ZG6X5T US11655221 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195245 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195245&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253855 375977100 CHEMBL3972158 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1280613 FC(F)(F)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C22H22F3N3O2/c23-22(24,25)18-8-6-17(7-9-18)16-4-2-15(3-5-16)12-19(13-26)28-21(29)20-14-27-10-1-11-30-20/h2-9,19-20,27H,1,10-12,14H2,(H,28,29)/t19-,20-/m0/s1 USBDHHJQNTYSNJ-PMACEKPBSA-N 50195255 CHEMBL3945475::US10287258, Example 6::US10669245, Example 6::US11117874, Example 6::US11655221, Example 6::US11680049, Example 6 Dipeptidyl peptidase 1 36.3 US Patent 10.7270/Q2ZG6X5T US11655221 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195255 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195255&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253859 375977110 CHEMBL3945475 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1280614 Fc1ccc(cc1F)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C21H21F2N3O2/c22-18-7-6-16(11-19(18)23)15-4-2-14(3-5-15)10-17(12-24)26-21(27)20-13-25-8-1-9-28-20/h2-7,11,17,20,25H,1,8-10,13H2,(H,26,27)/t17-,20-/m0/s1 HSWVIXGRFREZJG-PXNSSMCTSA-N 385047 (2S)-N-[(1S)-1-Cyano-2-(3',4'-difluorobiphenyl-4-yl)ethyl]-1,4-oxazepane-2- carboxamide::US10287258, Example 7::US10669245, Example 7::US11117874, Example 7::US11655221, Example 7::US11667615, Example 7::US11680049, Example 7 Dipeptidyl peptidase 1 69.2 US Patent 10.7270/Q2ZG6X5T US11655221 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385047&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253829 404854270 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1280615 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(nc1)C#N)C#N)[C@@H]1CNCCCO1 InChI=1S/C21H21N5O2/c22-11-18-7-6-17(13-25-18)16-4-2-15(3-5-16)10-19(12-23)26-21(27)20-14-24-8-1-9-28-20/h2-7,13,19-20,24H,1,8-10,14H2,(H,26,27)/t19-,20-/m0/s1 UZXVZQQAOVNOKG-PMACEKPBSA-N 385048 (2S)-N-{(1S)-1-Cyano-2-[4-(6-cyanopyridin-3-yl)phenyl]ethyl}-1,4-oxazepane-2- carboxamide::US10287258, Example 8::US10669245, Example 8::US11117874, Example 8::US11655221, Example 8::US11667615, Example 8::US11680049, Example 8 Dipeptidyl peptidase 1 87.1 US Patent 10.7270/Q2ZG6X5T US11655221 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385048&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253853 404854271 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1280616 CN1C(=O)CSc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H26N4O3S/c1-28-20-12-18(7-8-22(20)32-15-23(28)29)17-5-3-16(4-6-17)11-19(13-25)27-24(30)21-14-26-9-2-10-31-21/h3-8,12,19,21,26H,2,9-11,14-15H2,1H3,(H,27,30)/t19-,21-/m0/s1 NSLGCWMFHWURGT-FPOVZHCZSA-N 385049 (2S)-N-{(1S)-1-Cyano-2-[4-(4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzothiazin-6- yl)phenyl]ethyl}-1,4-oxazepane-2-carboxamide::US10287258, Example 9::US10669245, Example 9::US11117874, Example 9::US11655221, Example 9::US11667615, Example 9::US11680049, Example 9 Dipeptidyl peptidase 1 12.9 US Patent 10.7270/Q2ZG6X5T US11655221 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385049&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253849 404854272 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1280617 CCn1c2cc(cc(C)c2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C25H28N4O4/c1-3-29-21-13-19(11-16(2)23(21)33-25(29)31)18-7-5-17(6-8-18)12-20(14-26)28-24(30)22-15-27-9-4-10-32-22/h5-8,11,13,20,22,27H,3-4,9-10,12,15H2,1-2H3,(H,28,30)/t20-,22-/m0/s1 ORHUZDNZRYZSJO-UNMCSNQZSA-N 385050 (2S)-N-{(1S)-1-Cyano-2-[4-(3-ethyl-7-methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-5- yl)phenyl]ethyl}-1,4-oxazepane-2-carboxamide::US10287258, Example 10::US10669245, Example 10::US11117874, Example 10::US11655221, Example 10::US11680049, Example 10 Dipeptidyl peptidase 1 21.4 US Patent 10.7270/Q2ZG6X5T US11655221 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385050&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253835 404854273 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1280618 CC(C)(O)Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C26H30N4O5/c1-26(2,33)16-30-21-13-19(8-9-22(21)35-25(30)32)18-6-4-17(5-7-18)12-20(14-27)29-24(31)23-15-28-10-3-11-34-23/h4-9,13,20,23,28,33H,3,10-12,15-16H2,1-2H3,(H,29,31)/t20-,23-/m0/s1 LRDOUIXCGZNESR-REWPJTCUSA-N 385051 (2S)-N-[(1S)-1-Cyano-2-{4-[3-(2-hydroxy-2-methylpropyl)-2-oxo-2,3-dihydro-1,3- benzoxazol-5-yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 11::US10669245, Example 11::US11117874, Example 11::US11655221, Example 11::US11667615, Example 11::US11680049, Example 11 Dipeptidyl peptidase 1 89.1 US Patent 10.7270/Q2ZG6X5T US11655221 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385051&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253819 404854274 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1280619 FC(F)Cn1c2cc(cc(F)c2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H23F3N4O4/c25-18-9-16(10-19-22(18)35-24(33)31(19)13-21(26)27)15-4-2-14(3-5-15)8-17(11-28)30-23(32)20-12-29-6-1-7-34-20/h2-5,9-10,17,20-21,29H,1,6-8,12-13H2,(H,30,32)/t17-,20-/m0/s1 PVRGXPYTNXSTMU-PXNSSMCTSA-N 385052 (2S)-N-[(1S)-1-Cyano-2-{4-[3-(2,2-difluoroethyl)-7-fluoro-2-oxo-2,3-dihydro-1,3- benzoxazol-5-yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 12::US10669245, Example 12::US11117874, Example 12::US11655221, Example 12::US11667615, Example 12::US11680049, Example 12 Dipeptidyl peptidase 1 10.0 US Patent 10.7270/Q2ZG6X5T US11655221 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385052&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253812 404854275 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1280620 CN(C)CCn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C26H31N5O4/c1-30(2)11-12-31-22-15-20(8-9-23(22)35-26(31)33)19-6-4-18(5-7-19)14-21(16-27)29-25(32)24-17-28-10-3-13-34-24/h4-9,15,21,24,28H,3,10-14,17H2,1-2H3,(H,29,32)/t21-,24-/m0/s1 BVHRFMZXVRJZAF-URXFXBBRSA-N 385053 (2S)-N-[(1S)-1-Cyano-2-(4-{3-[2-(dimethylamino)ethyl]-2-oxo-2,3-dihydro-1,3- benzoxazol-5-yl}pheny)ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 13::US10669245, Example 13::US11117874, Example 13::US11655221, Example 13::US11667615, Example 13::US11680049, Example 13 Dipeptidyl peptidase 1 7.24 US Patent 10.7270/Q2ZG6X5T US11655221 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385053&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253865 404854276 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1280621 CN1C(=O)C(F)(F)c2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H24F2N4O3/c1-30-20-12-17(7-8-19(20)24(25,26)23(30)32)16-5-3-15(4-6-16)11-18(13-27)29-22(31)21-14-28-9-2-10-33-21/h3-8,12,18,21,28H,2,9-11,14H2,1H3,(H,29,31)/t18-,21-/m0/s1 SABYNPLHFAPZQF-RXVVDRJESA-N 50195242 CHEMBL3917575::US10287258, Example 14::US10669245, Example 14::US11117874, Example 14::US11655221, Example 14::US11680049, Example 14 Dipeptidyl peptidase 1 16.6 US Patent 10.7270/Q2ZG6X5T US11655221 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195242&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253811 375977097 CHEMBL3917575 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1280622 Cn1c2cc(cc(F)c2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H23FN4O4/c1-28-19-11-16(10-18(24)21(19)32-23(28)30)15-5-3-14(4-6-15)9-17(12-25)27-22(29)20-13-26-7-2-8-31-20/h3-6,10-11,17,20,26H,2,7-9,13H2,1H3,(H,27,29)/t17-,20-/m0/s1 IVHOZTBKWBUDMJ-PXNSSMCTSA-N 385055 (2S)-N-{(1S)-1-Cyano-2-[4-(7-fluoro-3-methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-5- yl)phenyl]ethyl}-1,4-oxazepane-2-carboxamide::US10287258, Example 15::US10669245, Example 15::US11117874, Example 15::US11655221, Example 15::US11667615, Example 15::US11680049, Example 15 Dipeptidyl peptidase 1 5.13 US Patent 10.7270/Q2ZG6X5T US11655221 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385055&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253861 404854278 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1280623 CCn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H26N4O4/c1-2-28-20-13-18(8-9-21(20)32-24(28)30)17-6-4-16(5-7-17)12-19(14-25)27-23(29)22-15-26-10-3-11-31-22/h4-9,13,19,22,26H,2-3,10-12,15H2,1H3,(H,27,29)/t19-,22-/m0/s1 HZZYFVOLMKQYKP-UGKGYDQZSA-N 50195246 CHEMBL3980602::US10287258, Example 16::US10669245, Example 16::US11117874, Example 16::US11655221, Example 16 Dipeptidyl peptidase 1 5.75 US Patent 10.7270/Q2ZG6X5T US11655221 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195246 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195246&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253883 375977101 CHEMBL3980602 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1280624 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2oc(=O)n(CC3CC3)c2c1)C#N)[C@@H]1CNCCCO1 InChI=1S/C26H28N4O4/c27-14-21(29-25(31)24-15-28-10-1-11-33-24)12-17-4-6-19(7-5-17)20-8-9-23-22(13-20)30(26(32)34-23)16-18-2-3-18/h4-9,13,18,21,24,28H,1-3,10-12,15-16H2,(H,29,31)/t21-,24-/m0/s1 WJXGZWWSCFPECN-URXFXBBRSA-N 385057 (2S)-N-[(1S)-1-Cyano-2-{4-[3-(cyclopropylmethyl)-2-oxo-2,3-dihydro-1,3-benzoxazol- 5-yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 17::US10669245, Example 17::US11117874, Example 17::US11655221, Example 17::US11667615, Example 17::US11680049, Example 17 Dipeptidyl peptidase 1 6.31 US Patent 10.7270/Q2ZG6X5T US11655221 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385057&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253827 404854280 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1280625 COCCn1c2cc(ccc2sc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C25H28N4O4S/c1-32-12-10-29-21-14-19(7-8-23(21)34-25(29)31)18-5-3-17(4-6-18)13-20(15-26)28-24(30)22-16-27-9-2-11-33-22/h3-8,14,20,22,27H,2,9-13,16H2,1H3,(H,28,30)/t20-,22-/m0/s1 GRJJVLYWMJAVMA-UNMCSNQZSA-N 385058 (2S)-N-[(1S)-1-Cyano-2-{4-[3-(2-methoxyethyl)-2-oxo-2,3-dihydro-1,3-benzothiazol- 5-yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 18::US10669245, Example 18::US11117874, Example 18::US11655221, Example 18::US11667615, Example 18::US11680049, Example 18 Dipeptidyl peptidase 1 3.16 US Patent 10.7270/Q2ZG6X5T US11655221 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385058&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253842 404854281 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1280626 CC(C)n1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C25H28N4O4/c1-16(2)29-21-13-19(8-9-22(21)33-25(29)31)18-6-4-17(5-7-18)12-20(14-26)28-24(30)23-15-27-10-3-11-32-23/h4-9,13,16,20,23,27H,3,10-12,15H2,1-2H3,(H,28,30)/t20-,23-/m0/s1 WOBKXJRTDASPHQ-REWPJTCUSA-N 385059 (2S)-N- [(1S)-1-Cyano-2-{4-[2-oxo-3-(propan-2-yl)-2,3-dihydro-1,3-benzoxazol-5- yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 19::US10669245, Example 19::US11117874, Example 19::US11655221, Example 19::US11667615, Example 19::US11680049, Example 19 Dipeptidyl peptidase 1 14.5 US Patent 10.7270/Q2ZG6X5T US11655221 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385059&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253878 404854282 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1280627 CN1C(=O)COc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H26N4O4/c1-28-20-12-18(7-8-21(20)32-15-23(28)29)17-5-3-16(4-6-17)11-19(13-25)27-24(30)22-14-26-9-2-10-31-22/h3-8,12,19,22,26H,2,9-11,14-15H2,1H3,(H,27,30)/t19-,22-/m0/s1 QKDQSHLZLZUQOA-UGKGYDQZSA-N 50195238 CHEMBL3962926::US10287258, Example 20::US10669245, Example 20::US11117874, Example 20::US11655221, Example 20::US11680049, Example 20 Dipeptidyl peptidase 1 12.6 US Patent 10.7270/Q2ZG6X5T US11655221 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195238 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195238&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253870 375977093 CHEMBL3962926 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1280628 COCCn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C25H28N4O5/c1-32-12-10-29-21-14-19(7-8-22(21)34-25(29)31)18-5-3-17(4-6-18)13-20(15-26)28-24(30)23-16-27-9-2-11-33-23/h3-8,14,20,23,27H,2,9-13,16H2,1H3,(H,28,30)/t20-,23-/m0/s1 JUXOTDAODWSCQS-REWPJTCUSA-N 385061 (2S)-N-[(1S)-1-Cyano-2-{4-[3-(2-methoxyethyl)-2-oxo-2,3-dihydro-1,3-benzoxazol-5- yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 21::US10669245, Example 21::US11117874, Example 21::US11655221, Example 21::US11667615, Example 21::US11680049, Example 21 Dipeptidyl peptidase 1 8.13 US Patent 10.7270/Q2ZG6X5T US11655221 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385061&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253879 404854284 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1280629 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(s1)C#N)C#N)[C@@H]1CNCCCO1 InChI=1S/C20H20N4O2S/c21-11-16(24-20(25)18-13-23-8-1-9-26-18)10-14-2-4-15(5-3-14)19-7-6-17(12-22)27-19/h2-7,16,18,23H,1,8-10,13H2,(H,24,25)/t16-,18-/m0/s1 AYKAKRZDQIFHMD-WMZOPIPTSA-N 385062 (2S)-N-{(1S)-1-Cyano-2-[4-(5-cyanothiophen-2-yl)phenyl]ethyl}-1,4-oxazepane-2- carboxamide::US10287258, Example 22::US10669245, Example 22::US11117874, Example 22::US11655221, Example 22::US11667615, Example 22::US11680049, Example 22 Dipeptidyl peptidase 1 19.5 US Patent 10.7270/Q2ZG6X5T US11655221 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385062&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253837 404854285 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1280630 NC(=O)c1ccc(cc1F)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C22H23FN4O3/c23-19-11-16(6-7-18(19)21(25)28)15-4-2-14(3-5-15)10-17(12-24)27-22(29)20-13-26-8-1-9-30-20/h2-7,11,17,20,26H,1,8-10,13H2,(H2,25,28)(H,27,29)/t17-,20-/m0/s1 GCGGEFOSHQPZEX-PXNSSMCTSA-N 385063 (2S)-N-[(1S)-2-(4'-Carbamoy1-3'-fluorobiphenyl-4-yl)-1-cyanoethyl]-1,4-oxazepane-2- carboxamide::US10287258, Example 23::US10669245, Example 23::US11117874, Example 23::US11655221, Example 23::US11667615, Example 23::US11680049, Example 23 Dipeptidyl peptidase 1 67.6 US Patent 10.7270/Q2ZG6X5T US11655221 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385063&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253894 404854286 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1280631 Cn1c2cc(ccc2ccc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C25H26N4O3/c1-29-22-14-20(8-7-19(22)9-10-24(29)30)18-5-3-17(4-6-18)13-21(15-26)28-25(31)23-16-27-11-2-12-32-23/h3-10,14,21,23,27H,2,11-13,16H2,1H3,(H,28,31)/t21-,23-/m0/s1 BQIZWZAQEICNDG-GMAHTHKFSA-N 50195244 CHEMBL3926554::US10287258, Example 24::US10669245, Example 24::US11117874, Example 24::US11655221, Example 24::US11680049, Example 24 Dipeptidyl peptidase 1 13.8 US Patent 10.7270/Q2ZG6X5T US11655221 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195244&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253851 375977099 CHEMBL3926554 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1280632 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2oc(=O)n(CC3CCOCC3)c2c1)C#N)[C@@H]1CNCCCO1 InChI=1S/C28H32N4O5/c29-16-23(31-27(33)26-17-30-10-1-11-36-26)14-19-2-4-21(5-3-19)22-6-7-25-24(15-22)32(28(34)37-25)18-20-8-12-35-13-9-20/h2-7,15,20,23,26,30H,1,8-14,17-18H2,(H,31,33)/t23-,26-/m0/s1 KFOHIWSKADTAQW-OZXSUGGESA-N 385065 (2S)-N-[(1S)-1-Cyano-2-{4-[2-oxo-3-(tetrahydro-2H-pyran-4-ylmethyl)-2,3-dihydro- 1,3-benzoxazol-5-yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 25::US10669245, Example 25::US11117874, Example 25::US11655221, Example 25::US11667615, Example 25::US11680049, Example 25 Dipeptidyl peptidase 1 10.7 US Patent 10.7270/Q2ZG6X5T US11655221 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385065&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253876 404854288 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1280633 Cn1c2cc(cc(Cl)c2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H23ClN4O4/c1-28-19-11-16(10-18(24)21(19)32-23(28)30)15-5-3-14(4-6-15)9-17(12-25)27-22(29)20-13-26-7-2-8-31-20/h3-6,10-11,17,20,26H,2,7-9,13H2,1H3,(H,27,29)/t17-,20-/m0/s1 KTGYWWMCWUTXTI-PXNSSMCTSA-N 385066 (2S)-N-{(1S)-2-[4-(7-Chloro-3-methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)phenyl]- 1-cyanoethyl}-1,4-oxazepane-2-carboxamide::US10287258, Example 26::US10669245, Example 26::US11117874, Example 26::US11655221, Example 26::US11667615, Example 26::US11680049, Example 26 Dipeptidyl peptidase 1 13.5 US Patent 10.7270/Q2ZG6X5T US11655221 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385066&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253874 404854289 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1280634 FC(F)Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H24F2N4O4/c25-22(26)14-30-19-11-17(6-7-20(19)34-24(30)32)16-4-2-15(3-5-16)10-18(12-27)29-23(31)21-13-28-8-1-9-33-21/h2-7,11,18,21-22,28H,1,8-10,13-14H2,(H,29,31)/t18-,21-/m0/s1 ANPJTTUBCRFBKA-RXVVDRJESA-N 50195248 CHEMBL3891374::US10287258, Example 27::US10669245, Example 27::US11117874, Example 27::US11655221, Example 27::US11680049, Example 27 Dipeptidyl peptidase 1 6.61 US Patent 10.7270/Q2ZG6X5T US11655221 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195248 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195248&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253888 375977103 CHEMBL3891374 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1280635 FC(F)(F)Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H23F3N4O4/c25-24(26,27)14-31-19-11-17(6-7-20(19)35-23(31)33)16-4-2-15(3-5-16)10-18(12-28)30-22(32)21-13-29-8-1-9-34-21/h2-7,11,18,21,29H,1,8-10,13-14H2,(H,30,32)/t18-,21-/m0/s1 KAGSLWGZQVTFPB-RXVVDRJESA-N 385068 (2S)-N-[(1S)-1-Cyano-2-{4-[2-oxo-3-(2,2,2-trifluoroethyl)-2,3-dihydro-1,3- benzoxazol-5-yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 28::US10669245, Example 28::US11117874, Example 28::US11655221, Example 28::US11667615, Example 28::US11680049, Example 28 Dipeptidyl peptidase 1 8.13 US Patent 10.7270/Q2ZG6X5T US11655221 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385068&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253867 404854291 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1280636 Cn1c2cc(ccc2sc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H24N4O3S/c1-27-19-12-17(7-8-21(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)20-14-25-9-2-10-30-20/h3-8,12,18,20,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,20-/m0/s1 DRQDONWWFWYTII-ICSRJNTNSA-N 50195239 CHEMBL3972563::US10287258, Example 29::US10669245, Example 29::US11117874, Example 29::US11655221, Example 29::US11680049, Example 29 Dipeptidyl peptidase 1 2.40 US Patent 10.7270/Q2ZG6X5T US11655221 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195239&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 91826235 375977094 CHEMBL3972563 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1280637 CS(=O)(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C22H25N3O4S/c1-30(27,28)20-9-7-18(8-10-20)17-5-3-16(4-6-17)13-19(14-23)25-22(26)21-15-24-11-2-12-29-21/h3-10,19,21,24H,2,11-13,15H2,1H3,(H,25,26)/t19-,21-/m0/s1 UBRDXNDHEGQOTI-FPOVZHCZSA-N 385070 (2S)-N-{(1S)-1-Cyano-2-[4'-(methylsulfonyl)bipheny1-4-yl]ethyl}-1,4-oxazepane-2- carboxamide::US10287258, Example 30::US10669245, Example 30::US11117874, Example 30::US11655221, Example 30::US11667615, Example 30::US11680049, Example 30 Dipeptidyl peptidase 1 37.2 US Patent 10.7270/Q2ZG6X5T US11655221 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385070&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253895 404854293 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1280638 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N1CCC1)C#N)[C@@H]1CNCCCO1 InChI=1S/C24H28N4O4S/c25-16-21(27-24(29)23-17-26-11-1-14-32-23)15-18-3-5-19(6-4-18)20-7-9-22(10-8-20)33(30,31)28-12-2-13-28/h3-10,21,23,26H,1-2,11-15,17H2,(H,27,29)/t21-,23-/m0/s1 CBWWXOUBSQCMHB-GMAHTHKFSA-N 385071 (2S)-N-{(1S)-2-[4'-(Azetidin-1-ylsulfonyl)biphenyl-4-yl]-1-cyanoethyl}-1,4-oxazepane- 2-carboxamide::US10287258, Example 31::US10669245, Example 31::US11117874, Example 31::US11655221, Example 31::US11667615, Example 31::US11680049, Example 31 Dipeptidyl peptidase 1 21.4 US Patent 10.7270/Q2ZG6X5T US11655221 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385071&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253890 404854294 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1280639 Fc1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C21H22FN3O2/c22-18-8-6-17(7-9-18)16-4-2-15(3-5-16)12-19(13-23)25-21(26)20-14-24-10-1-11-27-20/h2-9,19-20,24H,1,10-12,14H2,(H,25,26)/t19-,20-/m0/s1 PYXGGJVWIVBQRO-PMACEKPBSA-N 385072 (2S)-N-[(1S)-1-Cyano-2-(4'-fluorobiphenyl-4-yl)ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 32::US10669245, Example 32::US11117874, Example 32::US11655221, Example 32::US11667615, Example 32::US11680049, Example 32 Dipeptidyl peptidase 1 42.7 US Patent 10.7270/Q2ZG6X5T US11655221 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385072&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253858 404854295 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1280640 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2scnc2c1)C#N)[C@@H]1CNCCCO1 InChI=1S/C22H22N4O2S/c23-12-18(26-22(27)20-13-24-8-1-9-28-20)10-15-2-4-16(5-3-15)17-6-7-21-19(11-17)25-14-29-21/h2-7,11,14,18,20,24H,1,8-10,13H2,(H,26,27)/t18-,20-/m0/s1 MUTKXUKCDAFWLB-ICSRJNTNSA-N 50195263 CHEMBL3942969::US10287258, Example 33::US10669245, Example 33::US11117874, Example 33::US11673871, Example 33::US11680049, Example 33 Dipeptidyl peptidase 1 61.7 US Patent 10.7270/Q2ZG6X5T US11655221 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195263&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253877 375977118 CHEMBL3942969 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1280641 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)C1CNCCCO1 InChI=1S/C22H22N4O2/c23-13-17-4-8-19(9-5-17)18-6-2-16(3-7-18)12-20(14-24)26-22(27)21-15-25-10-1-11-28-21/h2-9,20-21,25H,1,10-12,15H2,(H,26,27)/t20-,21?/m0/s1 FCRODBUNBQJNPU-BGERDNNASA-N 50195262 CHEMBL3966946::US11655221, Example 34 Dipeptidyl peptidase 1 60.3 US Patent 10.7270/Q2ZG6X5T US11655221 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195262 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195262&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118260121 375977117 CHEMBL3966946 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1280642 CN1C(=O)CNc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H27N5O3/c1-29-21-12-18(7-8-20(21)27-15-23(29)30)17-5-3-16(4-6-17)11-19(13-25)28-24(31)22-14-26-9-2-10-32-22/h3-8,12,19,22,26-27H,2,9-11,14-15H2,1H3,(H,28,31)/t19-,22-/m0/s1 CPBDCTBYFQTDMV-UGKGYDQZSA-N 385075 US10287258, Example 35::US10669245, Example 35::US11117874, Example 35::US11673871, Example 35::US11680049, Example 35 Dipeptidyl peptidase 1 24.5 US Patent 10.7270/Q2ZG6X5T US11655221 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385075&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253822 404854298 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1280643 CC[C@H](NC(=O)[C@@H]1CNCCCO1)\C=C\C(=O)N1CCc2ccccc12 InChI=1S/C20H27N3O3/c1-2-16(22-20(25)18-14-21-11-5-13-26-18)8-9-19(24)23-12-10-15-6-3-4-7-17(15)23/h3-4,6-9,16,18,21H,2,5,10-14H2,1H3,(H,22,25)/b9-8+/t16-,18-/m0/s1 OHNHQTNQBQMALV-LFGVRAQPSA-N 385076 BDBM445984::US10287258, Example 36::US11667615, Example 36::US11680049, Example 36 Dipeptidyl peptidase 1 5.01 US Patent 10.7270/Q2ZG6X5T US11655221 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385076&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 144891673 404854299 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1280644 CC(C)C[C@H](NC(=O)[C@@H]1CNCCCO1)\C=C\C(=O)N1CCc2ccccc12 InChI=1S/C22H31N3O3/c1-16(2)14-18(24-22(27)20-15-23-11-5-13-28-20)8-9-21(26)25-12-10-17-6-3-4-7-19(17)25/h3-4,6-9,16,18,20,23H,5,10-15H2,1-2H3,(H,24,27)/b9-8+/t18-,20+/m1/s1 PXFMGAFAIVURSO-ZZHWGSSASA-N 385077 BDBM445985::US10287258, Example 37::US11667615, Example 37::US11680049, Example 37 Dipeptidyl peptidase 1 5.25 US Patent 10.7270/Q2ZG6X5T US11655221 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385077&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 144891689 404854300 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1285118 CN1C(=O)CNc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H27N5O3/c1-29-21-12-18(7-8-20(21)27-15-23(29)30)17-5-3-16(4-6-17)11-19(13-25)28-24(31)22-14-26-9-2-10-32-22/h3-8,12,19,22,26-27H,2,9-11,14-15H2,1H3,(H,28,31)/t19-,22-/m0/s1 CPBDCTBYFQTDMV-UGKGYDQZSA-N 385075 US10287258, Example 35::US10669245, Example 35::US11117874, Example 35::US11673871, Example 35::US11680049, Example 35 Dipeptidyl peptidase 1 24.5 US Patent 10.7270/Q2FB56W4 US11673871 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385075&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253822 404854298 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1285119 CC[C@H](NC(=O)[C@@H]1CNCCCO1)\C=C\C(=O)N1CCc2ccccc12 InChI=1S/C20H27N3O3/c1-2-16(22-20(25)18-14-21-11-5-13-26-18)8-9-19(24)23-12-10-15-6-3-4-7-17(15)23/h3-4,6-9,16,18,21H,2,5,10-14H2,1H3,(H,22,25)/b9-8+/t16-,18-/m0/s1 OHNHQTNQBQMALV-LFGVRAQPSA-N 385076 BDBM445984::US10287258, Example 36::US11667615, Example 36::US11680049, Example 36 Dipeptidyl peptidase 1 5.01 US Patent 10.7270/Q2FB56W4 US11673871 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385076&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 144891673 404854299 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1285120 CC(C)C[C@H](NC(=O)[C@@H]1CNCCCO1)\C=C\C(=O)N1CCc2ccccc12 InChI=1S/C22H31N3O3/c1-16(2)14-18(24-22(27)20-15-23-11-5-13-28-20)8-9-21(26)25-12-10-17-6-3-4-7-19(17)25/h3-4,6-9,16,18,20,23H,5,10-15H2,1-2H3,(H,24,27)/b9-8+/t18-,20+/m1/s1 PXFMGAFAIVURSO-ZZHWGSSASA-N 385077 BDBM445985::US10287258, Example 37::US11667615, Example 37::US11680049, Example 37 Dipeptidyl peptidase 1 5.25 US Patent 10.7270/Q2FB56W4 US11673871 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=385077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=385077&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 144891689 404854300 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1285116 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2scnc2c1)C#N)[C@@H]1CNCCCO1 InChI=1S/C22H22N4O2S/c23-12-18(26-22(27)20-13-24-8-1-9-28-20)10-15-2-4-16(5-3-15)17-6-7-21-19(11-17)25-14-29-21/h2-7,11,14,18,20,24H,1,8-10,13H2,(H,26,27)/t18-,20-/m0/s1 MUTKXUKCDAFWLB-ICSRJNTNSA-N 50195263 CHEMBL3942969::US10287258, Example 33::US10669245, Example 33::US11117874, Example 33::US11673871, Example 33::US11680049, Example 33 Dipeptidyl peptidase 1 61.7 US Patent 10.7270/Q2FB56W4 US11673871 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195263&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253877 375977118 CHEMBL3942969 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1285117 O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)[C@@H]1CNCCCO1 InChI=1S/C22H22N4O2/c23-13-17-4-8-19(9-5-17)18-6-2-16(3-7-18)12-20(14-24)26-22(27)21-15-25-10-1-11-28-21/h2-9,20-21,25H,1,10-12,15H2,(H,26,27)/t20-,21-/m0/s1 FCRODBUNBQJNPU-SFTDATJTSA-N 50195236 CHEMBL3927609::US10287258, Example 1::US10669245, Example 1::US11117874, Example 1::US11673871, Example 34::US11680049, Example 1 Dipeptidyl peptidase 1 60.3 US Patent 10.7270/Q2FB56W4 US11673871 Lonn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Ponten, JF; Doyle, KJ; Van De Poel, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195236&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253857 375977091 CHEMBL3927609 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51501997 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2Cl)c1 InChI=1S/C20H13ClF3N5S/c21-16-10-26-19(28-17-5-4-12(9-25-17)13-6-7-30-11-13)29-18(16)27-15-3-1-2-14(8-15)20(22,23)24/h1-11H,(H2,25,26,27,28,29) WRTIVQWHCXIVQC-UHFFFAOYSA-N 50573824 CHEMBL4847055 Dipeptidyl peptidase 1 57 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573824&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768840 471063969 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51501998 Fc1cnc(Nc2ccc(cn2)-c2ccsc2)nc1Nc1cccc(c1)C(F)(F)F InChI=1S/C20H13F4N5S/c21-16-10-26-19(28-17-5-4-12(9-25-17)13-6-7-30-11-13)29-18(16)27-15-3-1-2-14(8-15)20(22,23)24/h1-11H,(H2,25,26,27,28,29) KRNIWFJLEHEGRG-UHFFFAOYSA-N 50573829 CHEMBL4875307 Dipeptidyl peptidase 1 66 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573829&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768829 471063974 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51501999 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2Br)c1 InChI=1S/C20H13BrF3N5S/c21-16-10-26-19(28-17-5-4-12(9-25-17)13-6-7-30-11-13)29-18(16)27-15-3-1-2-14(8-15)20(22,23)24/h1-11H,(H2,25,26,27,28,29) QEZWCFLEOPIAKW-UHFFFAOYSA-N 50605218 CHEMBL5206614 Dipeptidyl peptidase 1 99 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605218 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605218&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168297401 482616069 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502000 Cc1cnc(Nc2ccc(cn2)-c2ccsc2)nc1Nc1cccc(c1)C(F)(F)F InChI=1S/C21H16F3N5S/c1-13-10-26-20(28-18-6-5-14(11-25-18)15-7-8-30-12-15)29-19(13)27-17-4-2-3-16(9-17)21(22,23)24/h2-12H,1H3,(H2,25,26,27,28,29) OFOHMVCGHGFMDH-UHFFFAOYSA-N 50573830 CHEMBL4868834 Dipeptidyl peptidase 1 109 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573830&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768834 471063975 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502001 COc1cnc(Nc2ccc(cn2)-c2ccsc2)nc1Nc1cccc(c1)C(F)(F)F InChI=1S/C21H16F3N5OS/c1-30-17-11-26-20(28-18-6-5-13(10-25-18)14-7-8-31-12-14)29-19(17)27-16-4-2-3-15(9-16)21(22,23)24/h2-12H,1H3,(H2,25,26,27,28,29) BZPCXHXAPWYWEV-UHFFFAOYSA-N 50573831 CHEMBL4848242 Dipeptidyl peptidase 1 133 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573831&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768861 471063976 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502002 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2-c2ccoc2)c1 InChI=1S/C24H16F3N5OS/c25-24(26,27)18-2-1-3-19(10-18)30-22-20(16-6-8-33-13-16)12-29-23(32-22)31-21-5-4-15(11-28-21)17-7-9-34-14-17/h1-14H,(H2,28,29,30,31,32) KGYNDHCZUUPUDB-UHFFFAOYSA-N 50605219 CHEMBL5172531 Dipeptidyl peptidase 1 >5000 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605219 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605219&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168271118 482616070 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502003 Cn1cc(cn1)-c1cnc(Nc2ccc(cn2)-c2ccsc2)nc1Nc1cccc(c1)C(F)(F)F InChI=1S/C24H18F3N7S/c1-34-13-17(11-30-34)20-12-29-23(32-21-6-5-15(10-28-21)16-7-8-35-14-16)33-22(20)31-19-4-2-3-18(9-19)24(25,26)27/h2-14H,1H3,(H2,28,29,31,32,33) RWHYKFUMXGXUGY-UHFFFAOYSA-N 50605220 CHEMBL5177679 Dipeptidyl peptidase 1 248 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605220 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605220&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168277827 482616071 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502004 CN1CCC(=CC1)c1cnc(Nc2ccc(cn2)-c2ccsc2)nc1Nc1cccc(c1)C(F)(F)F InChI=1S/C26H23F3N6S/c1-35-10-7-17(8-11-35)22-15-31-25(33-23-6-5-18(14-30-23)19-9-12-36-16-19)34-24(22)32-21-4-2-3-20(13-21)26(27,28)29/h2-7,9,12-16H,8,10-11H2,1H3,(H2,30,31,32,33,34) CUUKUHWIYYAGQU-UHFFFAOYSA-N 50605221 CHEMBL5195835 Dipeptidyl peptidase 1 >5000 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605221 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605221&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168288061 482616072 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502005 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2-c2ccncc2)c1 InChI=1S/C25H17F3N6S/c26-25(27,28)19-2-1-3-20(12-19)32-23-21(16-6-9-29-10-7-16)14-31-24(34-23)33-22-5-4-17(13-30-22)18-8-11-35-15-18/h1-15H,(H2,30,31,32,33,34) QHTQRAWEYOBHEQ-UHFFFAOYSA-N 50605222 CHEMBL5174217 Dipeptidyl peptidase 1 >5000 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605222 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605222&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168273539 482616073 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502006 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2-c2ccccc2)c1 InChI=1S/C26H18F3N5S/c27-26(28,29)20-7-4-8-21(13-20)32-24-22(17-5-2-1-3-6-17)15-31-25(34-24)33-23-10-9-18(14-30-23)19-11-12-35-16-19/h1-16H,(H2,30,31,32,33,34) QMKNNEGMFCGQTO-UHFFFAOYSA-N 50605223 CHEMBL5189518 Dipeptidyl peptidase 1 >5000 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605223 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605223&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168282420 482616074 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502007 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2-c2ccc(Cl)cc2)c1 InChI=1S/C26H17ClF3N5S/c27-20-7-4-16(5-8-20)22-14-32-25(34-23-9-6-17(13-31-23)18-10-11-36-15-18)35-24(22)33-21-3-1-2-19(12-21)26(28,29)30/h1-15H,(H2,31,32,33,34,35) VLLIRJGICJWIFU-UHFFFAOYSA-N 50605224 CHEMBL5206777 Dipeptidyl peptidase 1 216 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605224 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605224&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168295668 482616075 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502008 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2-c2cccc(Cl)c2)c1 InChI=1S/C26H17ClF3N5S/c27-20-5-1-3-16(11-20)22-14-32-25(34-23-8-7-17(13-31-23)18-9-10-36-15-18)35-24(22)33-21-6-2-4-19(12-21)26(28,29)30/h1-15H,(H2,31,32,33,34,35) QPRJQHAZDRLXSL-UHFFFAOYSA-N 50605225 CHEMBL5184805 Dipeptidyl peptidase 1 >5000 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605225 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605225&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168282172 482616076 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502009 NC(=O)c1ccc(cc1)-c1cnc(Nc2ccc(cn2)-c2ccsc2)nc1Nc1cccc(c1)C(F)(F)F InChI=1S/C27H19F3N6OS/c28-27(29,30)20-2-1-3-21(12-20)34-25-22(16-4-6-17(7-5-16)24(31)37)14-33-26(36-25)35-23-9-8-18(13-32-23)19-10-11-38-15-19/h1-15H,(H2,31,37)(H2,32,33,34,35,36) JTKAVNDDWAVVLR-UHFFFAOYSA-N 50605226 CHEMBL5186296 Dipeptidyl peptidase 1 133 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605226 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605226&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168279233 482616077 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502010 NC(=O)c1cccc(c1)-c1cnc(Nc2ccc(cn2)-c2ccsc2)nc1Nc1cccc(c1)C(F)(F)F InChI=1S/C27H19F3N6OS/c28-27(29,30)20-5-2-6-21(12-20)34-25-22(16-3-1-4-17(11-16)24(31)37)14-33-26(36-25)35-23-8-7-18(13-32-23)19-9-10-38-15-19/h1-15H,(H2,31,37)(H2,32,33,34,35,36) NGACBAAYLMDCFT-UHFFFAOYSA-N 50605227 CHEMBL5208509 Dipeptidyl peptidase 1 >5000 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605227 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605227&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168297725 482616078 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502011 CC(=O)Nc1ccc(cc1)-c1cnc(Nc2ccc(cn2)-c2ccsc2)nc1Nc1cccc(c1)C(F)(F)F InChI=1S/C28H21F3N6OS/c1-17(38)34-22-8-5-18(6-9-22)24-15-33-27(36-25-10-7-19(14-32-25)20-11-12-39-16-20)37-26(24)35-23-4-2-3-21(13-23)28(29,30)31/h2-16H,1H3,(H,34,38)(H2,32,33,35,36,37) IKADAAAFTZQKFR-UHFFFAOYSA-N 50605228 CHEMBL5207778 Dipeptidyl peptidase 1 62 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605228 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605228&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 163409158 482616079 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502012 CC(=O)Nc1cccc(c1)-c1cnc(Nc2ccc(cn2)-c2ccsc2)nc1Nc1cccc(c1)C(F)(F)F InChI=1S/C28H21F3N6OS/c1-17(38)34-22-6-2-4-18(12-22)24-15-33-27(36-25-9-8-19(14-32-25)20-10-11-39-16-20)37-26(24)35-23-7-3-5-21(13-23)28(29,30)31/h2-16H,1H3,(H,34,38)(H2,32,33,35,36,37) HSKMGPMYKVEFJG-UHFFFAOYSA-N 50605229 CHEMBL5202703 Dipeptidyl peptidase 1 >5000 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605229 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605229&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168293939 482616080 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502013 CC(=O)c1cccc(c1)-c1cnc(Nc2ccc(cn2)-c2ccsc2)nc1Nc1cccc(c1)C(F)(F)F InChI=1S/C28H20F3N5OS/c1-17(37)18-4-2-5-19(12-18)24-15-33-27(35-25-9-8-20(14-32-25)21-10-11-38-16-21)36-26(24)34-23-7-3-6-22(13-23)28(29,30)31/h2-16H,1H3,(H2,32,33,34,35,36) ZMOZEVVIADAAHC-UHFFFAOYSA-N 50605230 CHEMBL5169830 Dipeptidyl peptidase 1 156 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605230 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605230&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168271023 482616081 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502014 CS(=O)(=O)c1ccc(cc1)-c1cnc(Nc2ccc(cn2)-c2ccsc2)nc1Nc1cccc(c1)C(F)(F)F InChI=1S/C27H20F3N5O2S2/c1-39(36,37)22-8-5-17(6-9-22)23-15-32-26(34-24-10-7-18(14-31-24)19-11-12-38-16-19)35-25(23)33-21-4-2-3-20(13-21)27(28,29)30/h2-16H,1H3,(H2,31,32,33,34,35) XGEXNSZQWMYMCU-UHFFFAOYSA-N 50605231 CHEMBL5176848 Dipeptidyl peptidase 1 >5000 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605231 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605231&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168276563 482616082 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502015 Nc1ccc(cc1)-c1cnc(Nc2ccc(cn2)-c2ccsc2)nc1Nc1cccc(c1)C(F)(F)F InChI=1S/C26H19F3N6S/c27-26(28,29)19-2-1-3-21(12-19)33-24-22(16-4-7-20(30)8-5-16)14-32-25(35-24)34-23-9-6-17(13-31-23)18-10-11-36-15-18/h1-15H,30H2,(H2,31,32,33,34,35) KMGCPKDAPLNDRR-UHFFFAOYSA-N 50605232 CHEMBL5176578 Dipeptidyl peptidase 1 >5000 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605232 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605232&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168272562 482616083 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502016 CN1CCN(CC1)c1ccc(cc1)-c1cnc(Nc2ccc(cn2)-c2ccsc2)nc1Nc1cccc(c1)C(F)(F)F InChI=1S/C31H28F3N7S/c1-40-12-14-41(15-13-40)26-8-5-21(6-9-26)27-19-36-30(38-28-10-7-22(18-35-28)23-11-16-42-20-23)39-29(27)37-25-4-2-3-24(17-25)31(32,33)34/h2-11,16-20H,12-15H2,1H3,(H2,35,36,37,38,39) XYOHWVORCBBKOF-UHFFFAOYSA-N 50605233 CHEMBL5198107 Dipeptidyl peptidase 1 >5000 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605233 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605233&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168289065 482616084 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502017 CN1CCN(Cc2ccc(cc2)-c2cnc(Nc3ccc(cn3)-c3ccsc3)nc2Nc2cccc(c2)C(F)(F)F)CC1 InChI=1S/C32H30F3N7S/c1-41-12-14-42(15-13-41)20-22-5-7-23(8-6-22)28-19-37-31(39-29-10-9-24(18-36-29)25-11-16-43-21-25)40-30(28)38-27-4-2-3-26(17-27)32(33,34)35/h2-11,16-19,21H,12-15,20H2,1H3,(H2,36,37,38,39,40) RJKKBSVUDSLXMC-UHFFFAOYSA-N 50605234 CHEMBL5186113 Dipeptidyl peptidase 1 >5000 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605234 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605234&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168282652 482616085 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502018 Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H24N4O4/c1-27-19-12-17(7-8-20(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)21-14-25-9-2-10-30-21/h3-8,12,18,21,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,21-/m0/s1 AEXFXNFMSAAELR-RXVVDRJESA-N 50195235 CHEMBL3900409::US10287258, Example 2::US10669245, Example 2::US11117874, Example 2::US11655221, Example 2::US11680049, Example 2 Dipeptidyl peptidase 1 19 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195235&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253852 375977090 CHEMBL3900409 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502019 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(cc3)-c3ccsc3)ncc2Cl)c1 InChI=1S/C21H14ClF3N4S/c22-18-11-26-20(28-16-6-4-13(5-7-16)14-8-9-30-12-14)29-19(18)27-17-3-1-2-15(10-17)21(23,24)25/h1-12H,(H2,26,27,28,29) RHCGVRDKBMISGQ-UHFFFAOYSA-N 50605235 CHEMBL5191730 Dipeptidyl peptidase 1 >5000 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605235&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168288277 482616086 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502020 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(nc3)-c3ccsc3)ncc2Cl)c1 InChI=1S/C20H13ClF3N5S/c21-16-10-26-19(28-15-4-5-17(25-9-15)12-6-7-30-11-12)29-18(16)27-14-3-1-2-13(8-14)20(22,23)24/h1-11H,(H2,26,27,28,29) CMLIHNXRVQWYBQ-UHFFFAOYSA-N 50605236 CHEMBL5171002 Dipeptidyl peptidase 1 103 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605236&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168269572 482616087 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502021 FC(F)(F)c1cccc(Nc2nc(Nc3ncc(cn3)-c3ccsc3)ncc2Cl)c1 InChI=1S/C19H12ClF3N6S/c20-15-9-26-18(29-17-24-7-12(8-25-17)11-4-5-30-10-11)28-16(15)27-14-3-1-2-13(6-14)19(21,22)23/h1-10H,(H2,24,25,26,27,28,29) ZEUPIZNEEJEXDH-UHFFFAOYSA-N 50605237 CHEMBL5173569 Dipeptidyl peptidase 1 >5000 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605237 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605237&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168272458 482616088 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502022 FC(F)(F)c1cccc(Nc2nc(Nc3cnc(cn3)-c3ccsc3)ncc2Cl)c1 InChI=1S/C19H12ClF3N6S/c20-14-7-26-18(28-16-9-24-15(8-25-16)11-4-5-30-10-11)29-17(14)27-13-3-1-2-12(6-13)19(21,22)23/h1-10H,(H2,25,26,27,28,29) GBXRXXFHYLQEKQ-UHFFFAOYSA-N 50605238 CHEMBL5175900 Dipeptidyl peptidase 1 >5000 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605238 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605238&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168273070 482616089 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502023 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(nn3)-c3ccsc3)ncc2Cl)c1 InChI=1S/C19H12ClF3N6S/c20-14-9-24-18(26-16-5-4-15(28-29-16)11-6-7-30-10-11)27-17(14)25-13-3-1-2-12(8-13)19(21,22)23/h1-10H,(H2,24,25,26,27,29) KZZIRPQJBKCZNK-UHFFFAOYSA-N 50605239 CHEMBL5198638 Dipeptidyl peptidase 1 91 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605239&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168286013 482616090 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502024 [O-][N+](=O)c1cc(cnc1Nc1ncc(Cl)c(Nc2cccc(c2)C(F)(F)F)n1)-c1ccsc1 InChI=1S/C20H12ClF3N6O2S/c21-15-9-26-19(28-17(15)27-14-3-1-2-13(7-14)20(22,23)24)29-18-16(30(31)32)6-12(8-25-18)11-4-5-33-10-11/h1-10H,(H2,25,26,27,28,29) LHNBRBPQHIBQIE-UHFFFAOYSA-N 50605240 CHEMBL5208614 Dipeptidyl peptidase 1 152 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605240&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168295762 482616091 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502025 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(cn3)-c3cccs3)ncc2Cl)c1 InChI=1S/C20H13ClF3N5S/c21-15-11-26-19(28-17-7-6-12(10-25-17)16-5-2-8-30-16)29-18(15)27-14-4-1-3-13(9-14)20(22,23)24/h1-11H,(H2,25,26,27,28,29) DLSMFDJMEDXHOJ-UHFFFAOYSA-N 50605241 CHEMBL5180968 Dipeptidyl peptidase 1 128 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605241 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605241&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168275961 482616092 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502026 FC(F)(F)c1cccc(Nc2nc(Nc3cc(ccn3)-c3ccsc3)ncc2Cl)c1 InChI=1S/C20H13ClF3N5S/c21-16-10-26-19(28-17-8-12(4-6-25-17)13-5-7-30-11-13)29-18(16)27-15-3-1-2-14(9-15)20(22,23)24/h1-11H,(H2,25,26,27,28,29) KYQPZTULIQBFIM-UHFFFAOYSA-N 50605242 CHEMBL5205065 Dipeptidyl peptidase 1 78 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605242&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168297783 482616093 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502027 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(cn3)-c3ccco3)ncc2Cl)c1 InChI=1S/C20H13ClF3N5O/c21-15-11-26-19(28-17-7-6-12(10-25-17)16-5-2-8-30-16)29-18(15)27-14-4-1-3-13(9-14)20(22,23)24/h1-11H,(H2,25,26,27,28,29) ZPXVVWBRFQBCJI-UHFFFAOYSA-N 50605243 CHEMBL5179212 Dipeptidyl peptidase 1 >5000 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605243 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605243&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168276699 482616094 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502028 FC(F)(F)c1cccc(Nc2nc(Nc3cccc(c3)-c3ccsc3)ncc2Cl)c1 InChI=1S/C21H14ClF3N4S/c22-18-11-26-20(28-16-5-1-3-13(9-16)14-7-8-30-12-14)29-19(18)27-17-6-2-4-15(10-17)21(23,24)25/h1-12H,(H2,26,27,28,29) OSDVAFDKKPSJHP-UHFFFAOYSA-N 50605244 CHEMBL5189882 Dipeptidyl peptidase 1 66 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605244&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 163409159 482616095 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502029 FC(F)(F)Oc1ccc(Nc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2Cl)cc1 InChI=1S/C20H13ClF3N5OS/c21-16-10-26-19(28-17-6-1-12(9-25-17)13-7-8-31-11-13)29-18(16)27-14-2-4-15(5-3-14)30-20(22,23)24/h1-11H,(H2,25,26,27,28,29) VZKDIFHYZBRTOT-UHFFFAOYSA-N 50605245 CHEMBL5181508 Dipeptidyl peptidase 1 92 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605245 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605245&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168277226 482616096 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502030 FC(F)(F)Oc1cccc(Nc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2Cl)c1 InChI=1S/C20H13ClF3N5OS/c21-16-10-26-19(28-17-5-4-12(9-25-17)13-6-7-31-11-13)29-18(16)27-14-2-1-3-15(8-14)30-20(22,23)24/h1-11H,(H2,25,26,27,28,29) QOCXPFRFZAKBPW-UHFFFAOYSA-N 50605246 CHEMBL5189411 Dipeptidyl peptidase 1 252 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605246 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605246&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168281643 482616097 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502031 Fc1ccc(Nc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2Cl)cc1 InChI=1S/C19H13ClFN5S/c20-16-10-23-19(26-18(16)24-15-4-2-14(21)3-5-15)25-17-6-1-12(9-22-17)13-7-8-27-11-13/h1-11H,(H2,22,23,24,25,26) OEDKOGQVVSSEPE-UHFFFAOYSA-N 50605247 CHEMBL5185056 Dipeptidyl peptidase 1 128 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605247 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605247&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168280624 482616098 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502032 Fc1ccc(Nc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2Cl)cc1C(F)(F)F InChI=1S/C20H12ClF4N5S/c21-15-9-27-19(29-17-4-1-11(8-26-17)12-5-6-31-10-12)30-18(15)28-13-2-3-16(22)14(7-13)20(23,24)25/h1-10H,(H2,26,27,28,29,30) TYQXTKKNEIPCJE-UHFFFAOYSA-N 50605248 CHEMBL5176223 Dipeptidyl peptidase 1 143 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605248 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605248&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168273633 482616099 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502033 Fc1ccc(Nc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2Cl)cc1F InChI=1S/C19H12ClF2N5S/c20-14-9-24-19(27-18(14)25-13-2-3-15(21)16(22)7-13)26-17-4-1-11(8-23-17)12-5-6-28-10-12/h1-10H,(H2,23,24,25,26,27) BTUHWQKBTYQZAJ-UHFFFAOYSA-N 50605249 CHEMBL5200608 Dipeptidyl peptidase 1 100 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605249 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605249&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168292225 482616100 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502034 FC(F)(F)c1ccc(Nc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2Cl)cc1 InChI=1S/C20H13ClF3N5S/c21-16-10-26-19(28-17-6-1-12(9-25-17)13-7-8-30-11-13)29-18(16)27-15-4-2-14(3-5-15)20(22,23)24/h1-11H,(H2,25,26,27,28,29) CNTRCGCSHPFXBU-UHFFFAOYSA-N 50605250 CHEMBL5202532 Dipeptidyl peptidase 1 105 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605250 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605250&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168293834 482616101 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502035 FC(F)(F)c1ccc(CNc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2Cl)cc1 InChI=1S/C21H15ClF3N5S/c22-17-11-28-20(29-18-6-3-14(10-26-18)15-7-8-31-12-15)30-19(17)27-9-13-1-4-16(5-2-13)21(23,24)25/h1-8,10-12H,9H2,(H2,26,27,28,29,30) RWYLAESYOQQVDV-UHFFFAOYSA-N 50605251 CHEMBL5204393 Dipeptidyl peptidase 1 69 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605251 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605251&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168293488 482616102 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502036 Nc1ccc(Nc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2Cl)cc1 InChI=1S/C19H15ClN6S/c20-16-10-23-19(26-18(16)24-15-4-2-14(21)3-5-15)25-17-6-1-12(9-22-17)13-7-8-27-11-13/h1-11H,21H2,(H2,22,23,24,25,26) YJNKDMJBFHJGJJ-UHFFFAOYSA-N 50605252 CHEMBL5196138 Dipeptidyl peptidase 1 57 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605252 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605252&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168289983 482616103 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502037 Nc1cccc(Nc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2Cl)c1 InChI=1S/C19H15ClN6S/c20-16-10-23-19(26-18(16)24-15-3-1-2-14(21)8-15)25-17-5-4-12(9-22-17)13-6-7-27-11-13/h1-11H,21H2,(H2,22,23,24,25,26) WKADYGVZEMHTGP-UHFFFAOYSA-N 50605253 CHEMBL5183337 Dipeptidyl peptidase 1 133 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605253 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605253&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168279119 482616104 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502038 CC(=O)Nc1ccc(Nc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2Cl)cc1 InChI=1S/C21H17ClN6OS/c1-13(29)25-16-3-5-17(6-4-16)26-20-18(22)11-24-21(28-20)27-19-7-2-14(10-23-19)15-8-9-30-12-15/h2-12H,1H3,(H,25,29)(H2,23,24,26,27,28) UQNZKKXJBMSBJE-UHFFFAOYSA-N 50605254 CHEMBL5201740 Dipeptidyl peptidase 1 76 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605254 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605254&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168292028 482616105 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502039 CC(=O)Nc1cccc(Nc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2Cl)c1 InChI=1S/C21H17ClN6OS/c1-13(29)25-16-3-2-4-17(9-16)26-20-18(22)11-24-21(28-20)27-19-6-5-14(10-23-19)15-7-8-30-12-15/h2-12H,1H3,(H,25,29)(H2,23,24,26,27,28) CVEIEBFUSJRUSP-UHFFFAOYSA-N 50605255 CHEMBL5186557 Dipeptidyl peptidase 1 60 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605255 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605255&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 163409160 482616106 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502040 Clc1cnc(Nc2ccc(cn2)-c2ccsc2)nc1Nc1ccccn1 InChI=1S/C18H13ClN6S/c19-14-10-22-18(25-17(14)23-15-3-1-2-7-20-15)24-16-5-4-12(9-21-16)13-6-8-26-11-13/h1-11H,(H2,20,21,22,23,24,25) SQRJFCFZLHISBO-UHFFFAOYSA-N 50605256 CHEMBL5178862 Dipeptidyl peptidase 1 103 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605256 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605256&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168276688 482616107 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502041 Clc1cnc(Nc2ccc(cn2)-c2ccsc2)nc1NC1CCNCC1 InChI=1S/C18H19ClN6S/c19-15-10-22-18(25-17(15)23-14-3-6-20-7-4-14)24-16-2-1-12(9-21-16)13-5-8-26-11-13/h1-2,5,8-11,14,20H,3-4,6-7H2,(H2,21,22,23,24,25) MZYMYTQHMMTSON-UHFFFAOYSA-N 50605257 CHEMBL5187782 Dipeptidyl peptidase 1 92 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605257 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605257&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168278253 482616108 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502042 CN1CCN(CC1)c1ccc(Nc2ncc(Cl)c(Nc3cccc(c3)C(F)(F)F)n2)nc1 InChI=1S/C21H21ClF3N7/c1-31-7-9-32(10-8-31)16-5-6-18(26-12-16)29-20-27-13-17(22)19(30-20)28-15-4-2-3-14(11-15)21(23,24)25/h2-6,11-13H,7-10H2,1H3,(H2,26,27,28,29,30) JNAOGJWOQFVLOM-UHFFFAOYSA-N 50573801 CHEMBL4859234 Dipeptidyl peptidase 1 57 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573801&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768862 471063946 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502043 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(cn3)-c3ccoc3)ncc2Cl)c1 InChI=1S/C20H13ClF3N5O/c21-16-10-26-19(28-17-5-4-12(9-25-17)13-6-7-30-11-13)29-18(16)27-15-3-1-2-14(8-15)20(22,23)24/h1-11H,(H2,25,26,27,28,29) YUDMMRRZXOZNCH-UHFFFAOYSA-N 50573823 CHEMBL4855016 Dipeptidyl peptidase 1 >5000 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573823&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768863 471063968 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502044 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2Cl)c1 InChI=1S/C20H13ClF3N5S/c21-16-10-26-19(28-17-5-4-12(9-25-17)13-6-7-30-11-13)29-18(16)27-15-3-1-2-14(8-15)20(22,23)24/h1-11H,(H2,25,26,27,28,29) WRTIVQWHCXIVQC-UHFFFAOYSA-N 50573824 CHEMBL4847055 Dipeptidyl peptidase 1 42 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573824&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768840 471063969 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502045 Fc1cnc(Nc2ccc(cn2)-c2ccsc2)nc1Nc1cccc(c1)C(F)(F)F InChI=1S/C20H13F4N5S/c21-16-10-26-19(28-17-5-4-12(9-25-17)13-6-7-30-11-13)29-18(16)27-15-3-1-2-14(8-15)20(22,23)24/h1-11H,(H2,25,26,27,28,29) KRNIWFJLEHEGRG-UHFFFAOYSA-N 50573829 CHEMBL4875307 Dipeptidyl peptidase 1 90 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573829&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768829 471063974 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502046 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2Br)c1 InChI=1S/C20H13BrF3N5S/c21-16-10-26-19(28-17-5-4-12(9-25-17)13-6-7-30-11-13)29-18(16)27-15-3-1-2-14(8-15)20(22,23)24/h1-11H,(H2,25,26,27,28,29) QEZWCFLEOPIAKW-UHFFFAOYSA-N 50605218 CHEMBL5206614 Dipeptidyl peptidase 1 203 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605218 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605218&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168297401 482616069 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502047 Cc1cnc(Nc2ccc(cn2)-c2ccsc2)nc1Nc1cccc(c1)C(F)(F)F InChI=1S/C21H16F3N5S/c1-13-10-26-20(28-18-6-5-14(11-25-18)15-7-8-30-12-15)29-19(13)27-17-4-2-3-16(9-17)21(22,23)24/h2-12H,1H3,(H2,25,26,27,28,29) OFOHMVCGHGFMDH-UHFFFAOYSA-N 50573830 CHEMBL4868834 Dipeptidyl peptidase 1 90 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573830&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768834 471063975 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502048 COc1cnc(Nc2ccc(cn2)-c2ccsc2)nc1Nc1cccc(c1)C(F)(F)F InChI=1S/C21H16F3N5OS/c1-30-17-11-26-20(28-18-6-5-13(10-25-18)14-7-8-31-12-14)29-19(17)27-16-4-2-3-15(9-16)21(22,23)24/h2-12H,1H3,(H2,25,26,27,28,29) BZPCXHXAPWYWEV-UHFFFAOYSA-N 50573831 CHEMBL4848242 Dipeptidyl peptidase 1 100 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573831&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768861 471063976 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502049 Cn1cc(cn1)-c1cnc(Nc2ccc(cn2)-c2ccsc2)nc1Nc1cccc(c1)C(F)(F)F InChI=1S/C24H18F3N7S/c1-34-13-17(11-30-34)20-12-29-23(32-21-6-5-15(10-28-21)16-7-8-35-14-16)33-22(20)31-19-4-2-3-18(9-19)24(25,26)27/h2-14H,1H3,(H2,28,29,31,32,33) RWHYKFUMXGXUGY-UHFFFAOYSA-N 50605220 CHEMBL5177679 Dipeptidyl peptidase 1 >3000 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605220 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605220&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168277827 482616071 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502050 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2-c2ccc(Cl)cc2)c1 InChI=1S/C26H17ClF3N5S/c27-20-7-4-16(5-8-20)22-14-32-25(34-23-9-6-17(13-31-23)18-10-11-36-15-18)35-24(22)33-21-3-1-2-19(12-21)26(28,29)30/h1-15H,(H2,31,32,33,34,35) VLLIRJGICJWIFU-UHFFFAOYSA-N 50605224 CHEMBL5206777 Dipeptidyl peptidase 1 289 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605224 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605224&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168295668 482616075 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502051 NC(=O)c1ccc(cc1)-c1cnc(Nc2ccc(cn2)-c2ccsc2)nc1Nc1cccc(c1)C(F)(F)F InChI=1S/C27H19F3N6OS/c28-27(29,30)20-2-1-3-21(12-20)34-25-22(16-4-6-17(7-5-16)24(31)37)14-33-26(36-25)35-23-9-8-18(13-32-23)19-10-11-38-15-19/h1-15H,(H2,31,37)(H2,32,33,34,35,36) JTKAVNDDWAVVLR-UHFFFAOYSA-N 50605226 CHEMBL5186296 Dipeptidyl peptidase 1 357 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605226 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605226&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168279233 482616077 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502052 CC(=O)Nc1ccc(cc1)-c1cnc(Nc2ccc(cn2)-c2ccsc2)nc1Nc1cccc(c1)C(F)(F)F InChI=1S/C28H21F3N6OS/c1-17(38)34-22-8-5-18(6-9-22)24-15-33-27(36-25-10-7-19(14-32-25)20-11-12-39-16-20)37-26(24)35-23-4-2-3-21(13-23)28(29,30)31/h2-16H,1H3,(H,34,38)(H2,32,33,35,36,37) IKADAAAFTZQKFR-UHFFFAOYSA-N 50605228 CHEMBL5207778 Dipeptidyl peptidase 1 102 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605228 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605228&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 163409158 482616079 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502053 CC(=O)c1cccc(c1)-c1cnc(Nc2ccc(cn2)-c2ccsc2)nc1Nc1cccc(c1)C(F)(F)F InChI=1S/C28H20F3N5OS/c1-17(37)18-4-2-5-19(12-18)24-15-33-27(35-25-9-8-20(14-32-25)21-10-11-38-16-21)36-26(24)34-23-7-3-6-22(13-23)28(29,30)31/h2-16H,1H3,(H2,32,33,34,35,36) ZMOZEVVIADAAHC-UHFFFAOYSA-N 50605230 CHEMBL5169830 Dipeptidyl peptidase 1 308 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605230 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605230&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168271023 482616081 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502054 Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H24N4O4/c1-27-19-12-17(7-8-20(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)21-14-25-9-2-10-30-21/h3-8,12,18,21,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,21-/m0/s1 AEXFXNFMSAAELR-RXVVDRJESA-N 50195235 CHEMBL3900409::US10287258, Example 2::US10669245, Example 2::US11117874, Example 2::US11655221, Example 2::US11680049, Example 2 Dipeptidyl peptidase 1 10 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195235&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253852 375977090 CHEMBL3900409 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502055 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(nc3)-c3ccsc3)ncc2Cl)c1 InChI=1S/C20H13ClF3N5S/c21-16-10-26-19(28-15-4-5-17(25-9-15)12-6-7-30-11-12)29-18(16)27-14-3-1-2-13(8-14)20(22,23)24/h1-11H,(H2,26,27,28,29) CMLIHNXRVQWYBQ-UHFFFAOYSA-N 50605236 CHEMBL5171002 Dipeptidyl peptidase 1 160 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605236&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168269572 482616087 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502056 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(nn3)-c3ccsc3)ncc2Cl)c1 InChI=1S/C19H12ClF3N6S/c20-14-9-24-18(26-16-5-4-15(28-29-16)11-6-7-30-10-11)27-17(14)25-13-3-1-2-12(8-13)19(21,22)23/h1-10H,(H2,24,25,26,27,29) KZZIRPQJBKCZNK-UHFFFAOYSA-N 50605239 CHEMBL5198638 Dipeptidyl peptidase 1 90 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605239&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168286013 482616090 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502057 [O-][N+](=O)c1cc(cnc1Nc1ncc(Cl)c(Nc2cccc(c2)C(F)(F)F)n1)-c1ccsc1 InChI=1S/C20H12ClF3N6O2S/c21-15-9-26-19(28-17(15)27-14-3-1-2-13(7-14)20(22,23)24)29-18-16(30(31)32)6-12(8-25-18)11-4-5-33-10-11/h1-10H,(H2,25,26,27,28,29) LHNBRBPQHIBQIE-UHFFFAOYSA-N 50605240 CHEMBL5208614 Dipeptidyl peptidase 1 197 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605240&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168295762 482616091 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502058 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(cn3)-c3cccs3)ncc2Cl)c1 InChI=1S/C20H13ClF3N5S/c21-15-11-26-19(28-17-7-6-12(10-25-17)16-5-2-8-30-16)29-18(15)27-14-4-1-3-13(9-14)20(22,23)24/h1-11H,(H2,25,26,27,28,29) DLSMFDJMEDXHOJ-UHFFFAOYSA-N 50605241 CHEMBL5180968 Dipeptidyl peptidase 1 129 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605241 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605241&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168275961 482616092 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502059 FC(F)(F)c1cccc(Nc2nc(Nc3cc(ccn3)-c3ccsc3)ncc2Cl)c1 InChI=1S/C20H13ClF3N5S/c21-16-10-26-19(28-17-8-12(4-6-25-17)13-5-7-30-11-13)29-18(16)27-15-3-1-2-14(9-15)20(22,23)24/h1-11H,(H2,25,26,27,28,29) KYQPZTULIQBFIM-UHFFFAOYSA-N 50605242 CHEMBL5205065 Dipeptidyl peptidase 1 260 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605242&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168297783 482616093 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502060 FC(F)(F)c1cccc(Nc2nc(Nc3cccc(c3)-c3ccsc3)ncc2Cl)c1 InChI=1S/C21H14ClF3N4S/c22-18-11-26-20(28-16-5-1-3-13(9-16)14-7-8-30-12-14)29-19(18)27-17-6-2-4-15(10-17)21(23,24)25/h1-12H,(H2,26,27,28,29) OSDVAFDKKPSJHP-UHFFFAOYSA-N 50605244 CHEMBL5189882 Dipeptidyl peptidase 1 203 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605244&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 163409159 482616095 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502061 FC(F)(F)Oc1ccc(Nc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2Cl)cc1 InChI=1S/C20H13ClF3N5OS/c21-16-10-26-19(28-17-6-1-12(9-25-17)13-7-8-31-11-13)29-18(16)27-14-2-4-15(5-3-14)30-20(22,23)24/h1-11H,(H2,25,26,27,28,29) VZKDIFHYZBRTOT-UHFFFAOYSA-N 50605245 CHEMBL5181508 Dipeptidyl peptidase 1 110 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605245 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605245&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168277226 482616096 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502062 FC(F)(F)Oc1cccc(Nc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2Cl)c1 InChI=1S/C20H13ClF3N5OS/c21-16-10-26-19(28-17-5-4-12(9-25-17)13-6-7-31-11-13)29-18(16)27-14-2-1-3-15(8-14)30-20(22,23)24/h1-11H,(H2,25,26,27,28,29) QOCXPFRFZAKBPW-UHFFFAOYSA-N 50605246 CHEMBL5189411 Dipeptidyl peptidase 1 180 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605246 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605246&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168281643 482616097 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502063 Fc1ccc(Nc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2Cl)cc1 InChI=1S/C19H13ClFN5S/c20-16-10-23-19(26-18(16)24-15-4-2-14(21)3-5-15)25-17-6-1-12(9-22-17)13-7-8-27-11-13/h1-11H,(H2,22,23,24,25,26) OEDKOGQVVSSEPE-UHFFFAOYSA-N 50605247 CHEMBL5185056 Dipeptidyl peptidase 1 105 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605247 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605247&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168280624 482616098 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502064 Fc1ccc(Nc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2Cl)cc1C(F)(F)F InChI=1S/C20H12ClF4N5S/c21-15-9-27-19(29-17-4-1-11(8-26-17)12-5-6-31-10-12)30-18(15)28-13-2-3-16(22)14(7-13)20(23,24)25/h1-10H,(H2,26,27,28,29,30) TYQXTKKNEIPCJE-UHFFFAOYSA-N 50605248 CHEMBL5176223 Dipeptidyl peptidase 1 170 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605248 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605248&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168273633 482616099 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502065 Fc1ccc(Nc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2Cl)cc1F InChI=1S/C19H12ClF2N5S/c20-14-9-24-19(27-18(14)25-13-2-3-15(21)16(22)7-13)26-17-4-1-11(8-23-17)12-5-6-28-10-12/h1-10H,(H2,23,24,25,26,27) BTUHWQKBTYQZAJ-UHFFFAOYSA-N 50605249 CHEMBL5200608 Dipeptidyl peptidase 1 159 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605249 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605249&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168292225 482616100 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502066 FC(F)(F)c1ccc(Nc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2Cl)cc1 InChI=1S/C20H13ClF3N5S/c21-16-10-26-19(28-17-6-1-12(9-25-17)13-7-8-30-11-13)29-18(16)27-15-4-2-14(3-5-15)20(22,23)24/h1-11H,(H2,25,26,27,28,29) CNTRCGCSHPFXBU-UHFFFAOYSA-N 50605250 CHEMBL5202532 Dipeptidyl peptidase 1 184 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605250 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605250&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168293834 482616101 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502067 FC(F)(F)c1ccc(CNc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2Cl)cc1 InChI=1S/C21H15ClF3N5S/c22-17-11-28-20(29-18-6-3-14(10-26-18)15-7-8-31-12-15)30-19(17)27-9-13-1-4-16(5-2-13)21(23,24)25/h1-8,10-12H,9H2,(H2,26,27,28,29,30) RWYLAESYOQQVDV-UHFFFAOYSA-N 50605251 CHEMBL5204393 Dipeptidyl peptidase 1 90 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605251 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605251&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168293488 482616102 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502068 Nc1ccc(Nc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2Cl)cc1 InChI=1S/C19H15ClN6S/c20-16-10-23-19(26-18(16)24-15-4-2-14(21)3-5-15)25-17-6-1-12(9-22-17)13-7-8-27-11-13/h1-11H,21H2,(H2,22,23,24,25,26) YJNKDMJBFHJGJJ-UHFFFAOYSA-N 50605252 CHEMBL5196138 Dipeptidyl peptidase 1 111 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605252 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605252&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168289983 482616103 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502069 Nc1cccc(Nc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2Cl)c1 InChI=1S/C19H15ClN6S/c20-16-10-23-19(26-18(16)24-15-3-1-2-14(21)8-15)25-17-5-4-12(9-22-17)13-6-7-27-11-13/h1-11H,21H2,(H2,22,23,24,25,26) WKADYGVZEMHTGP-UHFFFAOYSA-N 50605253 CHEMBL5183337 Dipeptidyl peptidase 1 156 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605253 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605253&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168279119 482616104 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502070 CC(=O)Nc1ccc(Nc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2Cl)cc1 InChI=1S/C21H17ClN6OS/c1-13(29)25-16-3-5-17(6-4-16)26-20-18(22)11-24-21(28-20)27-19-7-2-14(10-23-19)15-8-9-30-12-15/h2-12H,1H3,(H,25,29)(H2,23,24,26,27,28) UQNZKKXJBMSBJE-UHFFFAOYSA-N 50605254 CHEMBL5201740 Dipeptidyl peptidase 1 64 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605254 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605254&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168292028 482616105 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502071 CC(=O)Nc1cccc(Nc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2Cl)c1 InChI=1S/C21H17ClN6OS/c1-13(29)25-16-3-2-4-17(9-16)26-20-18(22)11-24-21(28-20)27-19-6-5-14(10-23-19)15-7-8-30-12-15/h2-12H,1H3,(H,25,29)(H2,23,24,26,27,28) CVEIEBFUSJRUSP-UHFFFAOYSA-N 50605255 CHEMBL5186557 Dipeptidyl peptidase 1 115 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605255 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605255&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 163409160 482616106 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502072 Clc1cnc(Nc2ccc(cn2)-c2ccsc2)nc1Nc1ccccn1 InChI=1S/C18H13ClN6S/c19-14-10-22-18(25-17(14)23-15-3-1-2-7-20-15)24-16-5-4-12(9-21-16)13-6-8-26-11-13/h1-11H,(H2,20,21,22,23,24,25) SQRJFCFZLHISBO-UHFFFAOYSA-N 50605256 CHEMBL5178862 Dipeptidyl peptidase 1 141 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605256 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605256&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168276688 482616107 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502073 Clc1cnc(Nc2ccc(cn2)-c2ccsc2)nc1NC1CCNCC1 InChI=1S/C18H19ClN6S/c19-15-10-22-18(25-17(15)23-14-3-6-20-7-4-14)24-16-2-1-12(9-21-16)13-5-8-26-11-13/h1-2,5,8-11,14,20H,3-4,6-7H2,(H2,21,22,23,24,25) MZYMYTQHMMTSON-UHFFFAOYSA-N 50605257 CHEMBL5187782 Dipeptidyl peptidase 1 120 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605257 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605257&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168278253 482616108 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502074 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2-c2ccoc2)c1 InChI=1S/C24H16F3N5OS/c25-24(26,27)18-2-1-3-19(10-18)30-22-20(16-6-8-33-13-16)12-29-23(32-22)31-21-5-4-15(11-28-21)17-7-9-34-14-17/h1-14H,(H2,28,29,30,31,32) KGYNDHCZUUPUDB-UHFFFAOYSA-N 50605219 CHEMBL5172531 Dipeptidyl peptidase 1 >5000 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605219 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605219&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168271118 482616070 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502075 CN1CCC(=CC1)c1cnc(Nc2ccc(cn2)-c2ccsc2)nc1Nc1cccc(c1)C(F)(F)F InChI=1S/C26H23F3N6S/c1-35-10-7-17(8-11-35)22-15-31-25(33-23-6-5-18(14-30-23)19-9-12-36-16-19)34-24(22)32-21-4-2-3-20(13-21)26(27,28)29/h2-7,9,12-16H,8,10-11H2,1H3,(H2,30,31,32,33,34) CUUKUHWIYYAGQU-UHFFFAOYSA-N 50605221 CHEMBL5195835 Dipeptidyl peptidase 1 >5000 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605221 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605221&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168288061 482616072 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502076 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2-c2ccncc2)c1 InChI=1S/C25H17F3N6S/c26-25(27,28)19-2-1-3-20(12-19)32-23-21(16-6-9-29-10-7-16)14-31-24(34-23)33-22-5-4-17(13-30-22)18-8-11-35-15-18/h1-15H,(H2,30,31,32,33,34) QHTQRAWEYOBHEQ-UHFFFAOYSA-N 50605222 CHEMBL5174217 Dipeptidyl peptidase 1 >5000 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605222 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605222&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168273539 482616073 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502077 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2-c2ccccc2)c1 InChI=1S/C26H18F3N5S/c27-26(28,29)20-7-4-8-21(13-20)32-24-22(17-5-2-1-3-6-17)15-31-25(34-24)33-23-10-9-18(14-30-23)19-11-12-35-16-19/h1-16H,(H2,30,31,32,33,34) QMKNNEGMFCGQTO-UHFFFAOYSA-N 50605223 CHEMBL5189518 Dipeptidyl peptidase 1 >5000 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605223 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605223&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168282420 482616074 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502078 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2-c2cccc(Cl)c2)c1 InChI=1S/C26H17ClF3N5S/c27-20-5-1-3-16(11-20)22-14-32-25(34-23-8-7-17(13-31-23)18-9-10-36-15-18)35-24(22)33-21-6-2-4-19(12-21)26(28,29)30/h1-15H,(H2,31,32,33,34,35) QPRJQHAZDRLXSL-UHFFFAOYSA-N 50605225 CHEMBL5184805 Dipeptidyl peptidase 1 >5000 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605225 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605225&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168282172 482616076 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502079 NC(=O)c1cccc(c1)-c1cnc(Nc2ccc(cn2)-c2ccsc2)nc1Nc1cccc(c1)C(F)(F)F InChI=1S/C27H19F3N6OS/c28-27(29,30)20-5-2-6-21(12-20)34-25-22(16-3-1-4-17(11-16)24(31)37)14-33-26(36-25)35-23-8-7-18(13-32-23)19-9-10-38-15-19/h1-15H,(H2,31,37)(H2,32,33,34,35,36) NGACBAAYLMDCFT-UHFFFAOYSA-N 50605227 CHEMBL5208509 Dipeptidyl peptidase 1 >5000 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605227 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605227&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168297725 482616078 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502080 CC(=O)Nc1cccc(c1)-c1cnc(Nc2ccc(cn2)-c2ccsc2)nc1Nc1cccc(c1)C(F)(F)F InChI=1S/C28H21F3N6OS/c1-17(38)34-22-6-2-4-18(12-22)24-15-33-27(36-25-9-8-19(14-32-25)20-10-11-39-16-20)37-26(24)35-23-7-3-5-21(13-23)28(29,30)31/h2-16H,1H3,(H,34,38)(H2,32,33,35,36,37) HSKMGPMYKVEFJG-UHFFFAOYSA-N 50605229 CHEMBL5202703 Dipeptidyl peptidase 1 >5000 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605229 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605229&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168293939 482616080 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502081 CS(=O)(=O)c1ccc(cc1)-c1cnc(Nc2ccc(cn2)-c2ccsc2)nc1Nc1cccc(c1)C(F)(F)F InChI=1S/C27H20F3N5O2S2/c1-39(36,37)22-8-5-17(6-9-22)23-15-32-26(34-24-10-7-18(14-31-24)19-11-12-38-16-19)35-25(23)33-21-4-2-3-20(13-21)27(28,29)30/h2-16H,1H3,(H2,31,32,33,34,35) XGEXNSZQWMYMCU-UHFFFAOYSA-N 50605231 CHEMBL5176848 Dipeptidyl peptidase 1 >5000 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605231 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605231&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168276563 482616082 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502082 Nc1ccc(cc1)-c1cnc(Nc2ccc(cn2)-c2ccsc2)nc1Nc1cccc(c1)C(F)(F)F InChI=1S/C26H19F3N6S/c27-26(28,29)19-2-1-3-21(12-19)33-24-22(16-4-7-20(30)8-5-16)14-32-25(35-24)34-23-9-6-17(13-31-23)18-10-11-36-15-18/h1-15H,30H2,(H2,31,32,33,34,35) KMGCPKDAPLNDRR-UHFFFAOYSA-N 50605232 CHEMBL5176578 Dipeptidyl peptidase 1 >5000 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605232 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605232&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168272562 482616083 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502083 CN1CCN(CC1)c1ccc(cc1)-c1cnc(Nc2ccc(cn2)-c2ccsc2)nc1Nc1cccc(c1)C(F)(F)F InChI=1S/C31H28F3N7S/c1-40-12-14-41(15-13-40)26-8-5-21(6-9-26)27-19-36-30(38-28-10-7-22(18-35-28)23-11-16-42-20-23)39-29(27)37-25-4-2-3-24(17-25)31(32,33)34/h2-11,16-20H,12-15H2,1H3,(H2,35,36,37,38,39) XYOHWVORCBBKOF-UHFFFAOYSA-N 50605233 CHEMBL5198107 Dipeptidyl peptidase 1 >5000 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605233 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605233&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168289065 482616084 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502084 CN1CCN(Cc2ccc(cc2)-c2cnc(Nc3ccc(cn3)-c3ccsc3)nc2Nc2cccc(c2)C(F)(F)F)CC1 InChI=1S/C32H30F3N7S/c1-41-12-14-42(15-13-41)20-22-5-7-23(8-6-22)28-19-37-31(39-29-10-9-24(18-36-29)25-11-16-43-21-25)40-30(28)38-27-4-2-3-26(17-27)32(33,34)35/h2-11,16-19,21H,12-15,20H2,1H3,(H2,36,37,38,39,40) RJKKBSVUDSLXMC-UHFFFAOYSA-N 50605234 CHEMBL5186113 Dipeptidyl peptidase 1 >5000 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605234 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605234&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168282652 482616085 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502085 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(cc3)-c3ccsc3)ncc2Cl)c1 InChI=1S/C21H14ClF3N4S/c22-18-11-26-20(28-16-6-4-13(5-7-16)14-8-9-30-12-14)29-19(18)27-17-3-1-2-15(10-17)21(23,24)25/h1-12H,(H2,26,27,28,29) RHCGVRDKBMISGQ-UHFFFAOYSA-N 50605235 CHEMBL5191730 Dipeptidyl peptidase 1 >5000 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605235&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168288277 482616086 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502086 FC(F)(F)c1cccc(Nc2nc(Nc3ncc(cn3)-c3ccsc3)ncc2Cl)c1 InChI=1S/C19H12ClF3N6S/c20-15-9-26-18(29-17-24-7-12(8-25-17)11-4-5-30-10-11)28-16(15)27-14-3-1-2-13(6-14)19(21,22)23/h1-10H,(H2,24,25,26,27,28,29) ZEUPIZNEEJEXDH-UHFFFAOYSA-N 50605237 CHEMBL5173569 Dipeptidyl peptidase 1 >5000 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605237 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605237&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168272458 482616088 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502087 FC(F)(F)c1cccc(Nc2nc(Nc3cnc(cn3)-c3ccsc3)ncc2Cl)c1 InChI=1S/C19H12ClF3N6S/c20-14-7-26-18(28-16-9-24-15(8-25-16)11-4-5-30-10-11)29-17(14)27-13-3-1-2-12(6-13)19(21,22)23/h1-10H,(H2,25,26,27,28,29) GBXRXXFHYLQEKQ-UHFFFAOYSA-N 50605238 CHEMBL5175900 Dipeptidyl peptidase 1 >5000 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605238 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605238&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168273070 482616089 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502088 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(cn3)-c3ccco3)ncc2Cl)c1 InChI=1S/C20H13ClF3N5O/c21-15-11-26-19(28-17-7-6-12(10-25-17)16-5-2-8-30-16)29-18(15)27-14-4-1-3-13(9-14)20(22,23)24/h1-11H,(H2,25,26,27,28,29) ZPXVVWBRFQBCJI-UHFFFAOYSA-N 50605243 CHEMBL5179212 Dipeptidyl peptidase 1 >5000 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605243 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605243&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168276699 482616094 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502089 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2Cl)c1 InChI=1S/C20H13ClF3N5S/c21-16-10-26-19(28-17-5-4-12(9-25-17)13-6-7-30-11-13)29-18(16)27-15-3-1-2-14(8-15)20(22,23)24/h1-11H,(H2,25,26,27,28,29) WRTIVQWHCXIVQC-UHFFFAOYSA-N 50573824 CHEMBL4847055 Dipeptidyl peptidase 1 75 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573824&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768840 471063969 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502090 Fc1cnc(Nc2ccc(cn2)-c2ccsc2)nc1Nc1cccc(c1)C(F)(F)F InChI=1S/C20H13F4N5S/c21-16-10-26-19(28-17-5-4-12(9-25-17)13-6-7-30-11-13)29-18(16)27-15-3-1-2-14(8-15)20(22,23)24/h1-11H,(H2,25,26,27,28,29) KRNIWFJLEHEGRG-UHFFFAOYSA-N 50573829 CHEMBL4875307 Dipeptidyl peptidase 1 74 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573829&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768829 471063974 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502091 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2Br)c1 InChI=1S/C20H13BrF3N5S/c21-16-10-26-19(28-17-5-4-12(9-25-17)13-6-7-30-11-13)29-18(16)27-15-3-1-2-14(8-15)20(22,23)24/h1-11H,(H2,25,26,27,28,29) QEZWCFLEOPIAKW-UHFFFAOYSA-N 50605218 CHEMBL5206614 Dipeptidyl peptidase 1 180 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605218 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605218&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168297401 482616069 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502092 Cc1cnc(Nc2ccc(cn2)-c2ccsc2)nc1Nc1cccc(c1)C(F)(F)F InChI=1S/C21H16F3N5S/c1-13-10-26-20(28-18-6-5-14(11-25-18)15-7-8-30-12-15)29-19(13)27-17-4-2-3-16(9-17)21(22,23)24/h2-12H,1H3,(H2,25,26,27,28,29) OFOHMVCGHGFMDH-UHFFFAOYSA-N 50573830 CHEMBL4868834 Dipeptidyl peptidase 1 130 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573830&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768834 471063975 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502093 COc1cnc(Nc2ccc(cn2)-c2ccsc2)nc1Nc1cccc(c1)C(F)(F)F InChI=1S/C21H16F3N5OS/c1-30-17-11-26-20(28-18-6-5-13(10-25-18)14-7-8-31-12-14)29-19(17)27-16-4-2-3-15(9-16)21(22,23)24/h2-12H,1H3,(H2,25,26,27,28,29) BZPCXHXAPWYWEV-UHFFFAOYSA-N 50573831 CHEMBL4848242 Dipeptidyl peptidase 1 134 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573831&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156768861 471063976 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502094 Cn1cc(cn1)-c1cnc(Nc2ccc(cn2)-c2ccsc2)nc1Nc1cccc(c1)C(F)(F)F InChI=1S/C24H18F3N7S/c1-34-13-17(11-30-34)20-12-29-23(32-21-6-5-15(10-28-21)16-7-8-35-14-16)33-22(20)31-19-4-2-3-18(9-19)24(25,26)27/h2-14H,1H3,(H2,28,29,31,32,33) RWHYKFUMXGXUGY-UHFFFAOYSA-N 50605220 CHEMBL5177679 Dipeptidyl peptidase 1 416 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605220 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605220&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168277827 482616071 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502095 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2-c2ccc(Cl)cc2)c1 InChI=1S/C26H17ClF3N5S/c27-20-7-4-16(5-8-20)22-14-32-25(34-23-9-6-17(13-31-23)18-10-11-36-15-18)35-24(22)33-21-3-1-2-19(12-21)26(28,29)30/h1-15H,(H2,31,32,33,34,35) VLLIRJGICJWIFU-UHFFFAOYSA-N 50605224 CHEMBL5206777 Dipeptidyl peptidase 1 356 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605224 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605224&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168295668 482616075 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502096 NC(=O)c1ccc(cc1)-c1cnc(Nc2ccc(cn2)-c2ccsc2)nc1Nc1cccc(c1)C(F)(F)F InChI=1S/C27H19F3N6OS/c28-27(29,30)20-2-1-3-21(12-20)34-25-22(16-4-6-17(7-5-16)24(31)37)14-33-26(36-25)35-23-9-8-18(13-32-23)19-10-11-38-15-19/h1-15H,(H2,31,37)(H2,32,33,34,35,36) JTKAVNDDWAVVLR-UHFFFAOYSA-N 50605226 CHEMBL5186296 Dipeptidyl peptidase 1 285 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605226 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605226&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168279233 482616077 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502097 CC(=O)Nc1ccc(cc1)-c1cnc(Nc2ccc(cn2)-c2ccsc2)nc1Nc1cccc(c1)C(F)(F)F InChI=1S/C28H21F3N6OS/c1-17(38)34-22-8-5-18(6-9-22)24-15-33-27(36-25-10-7-19(14-32-25)20-11-12-39-16-20)37-26(24)35-23-4-2-3-21(13-23)28(29,30)31/h2-16H,1H3,(H,34,38)(H2,32,33,35,36,37) IKADAAAFTZQKFR-UHFFFAOYSA-N 50605228 CHEMBL5207778 Dipeptidyl peptidase 1 87 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605228 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605228&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 163409158 482616079 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502098 CC(=O)c1cccc(c1)-c1cnc(Nc2ccc(cn2)-c2ccsc2)nc1Nc1cccc(c1)C(F)(F)F InChI=1S/C28H20F3N5OS/c1-17(37)18-4-2-5-19(12-18)24-15-33-27(35-25-9-8-20(14-32-25)21-10-11-38-16-21)36-26(24)34-23-7-3-6-22(13-23)28(29,30)31/h2-16H,1H3,(H2,32,33,34,35,36) ZMOZEVVIADAAHC-UHFFFAOYSA-N 50605230 CHEMBL5169830 Dipeptidyl peptidase 1 228 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605230 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605230&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168271023 482616081 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502099 Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H24N4O4/c1-27-19-12-17(7-8-20(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)21-14-25-9-2-10-30-21/h3-8,12,18,21,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,21-/m0/s1 AEXFXNFMSAAELR-RXVVDRJESA-N 50195235 CHEMBL3900409::US10287258, Example 2::US10669245, Example 2::US11117874, Example 2::US11655221, Example 2::US11680049, Example 2 Dipeptidyl peptidase 1 15 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195235&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253852 375977090 CHEMBL3900409 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502100 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(nc3)-c3ccsc3)ncc2Cl)c1 InChI=1S/C20H13ClF3N5S/c21-16-10-26-19(28-15-4-5-17(25-9-15)12-6-7-30-11-12)29-18(16)27-14-3-1-2-13(8-14)20(22,23)24/h1-11H,(H2,26,27,28,29) CMLIHNXRVQWYBQ-UHFFFAOYSA-N 50605236 CHEMBL5171002 Dipeptidyl peptidase 1 216 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605236&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168269572 482616087 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502101 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(nn3)-c3ccsc3)ncc2Cl)c1 InChI=1S/C19H12ClF3N6S/c20-14-9-24-18(26-16-5-4-15(28-29-16)11-6-7-30-10-11)27-17(14)25-13-3-1-2-12(8-13)19(21,22)23/h1-10H,(H2,24,25,26,27,29) KZZIRPQJBKCZNK-UHFFFAOYSA-N 50605239 CHEMBL5198638 Dipeptidyl peptidase 1 181 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605239&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168286013 482616090 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502102 [O-][N+](=O)c1cc(cnc1Nc1ncc(Cl)c(Nc2cccc(c2)C(F)(F)F)n1)-c1ccsc1 InChI=1S/C20H12ClF3N6O2S/c21-15-9-26-19(28-17(15)27-14-3-1-2-13(7-14)20(22,23)24)29-18-16(30(31)32)6-12(8-25-18)11-4-5-33-10-11/h1-10H,(H2,25,26,27,28,29) LHNBRBPQHIBQIE-UHFFFAOYSA-N 50605240 CHEMBL5208614 Dipeptidyl peptidase 1 276 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605240&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168295762 482616091 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502103 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(cn3)-c3cccs3)ncc2Cl)c1 InChI=1S/C20H13ClF3N5S/c21-15-11-26-19(28-17-7-6-12(10-25-17)16-5-2-8-30-16)29-18(15)27-14-4-1-3-13(9-14)20(22,23)24/h1-11H,(H2,25,26,27,28,29) DLSMFDJMEDXHOJ-UHFFFAOYSA-N 50605241 CHEMBL5180968 Dipeptidyl peptidase 1 397 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605241 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605241&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168275961 482616092 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502104 FC(F)(F)c1cccc(Nc2nc(Nc3cc(ccn3)-c3ccsc3)ncc2Cl)c1 InChI=1S/C20H13ClF3N5S/c21-16-10-26-19(28-17-8-12(4-6-25-17)13-5-7-30-11-13)29-18(16)27-15-3-1-2-14(9-15)20(22,23)24/h1-11H,(H2,25,26,27,28,29) KYQPZTULIQBFIM-UHFFFAOYSA-N 50605242 CHEMBL5205065 Dipeptidyl peptidase 1 155 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605242&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168297783 482616093 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502105 FC(F)(F)c1cccc(Nc2nc(Nc3cccc(c3)-c3ccsc3)ncc2Cl)c1 InChI=1S/C21H14ClF3N4S/c22-18-11-26-20(28-16-5-1-3-13(9-16)14-7-8-30-12-14)29-19(18)27-17-6-2-4-15(10-17)21(23,24)25/h1-12H,(H2,26,27,28,29) OSDVAFDKKPSJHP-UHFFFAOYSA-N 50605244 CHEMBL5189882 Dipeptidyl peptidase 1 178 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605244&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 163409159 482616095 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502106 FC(F)(F)Oc1ccc(Nc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2Cl)cc1 InChI=1S/C20H13ClF3N5OS/c21-16-10-26-19(28-17-6-1-12(9-25-17)13-7-8-31-11-13)29-18(16)27-14-2-4-15(5-3-14)30-20(22,23)24/h1-11H,(H2,25,26,27,28,29) VZKDIFHYZBRTOT-UHFFFAOYSA-N 50605245 CHEMBL5181508 Dipeptidyl peptidase 1 154 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605245 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605245&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168277226 482616096 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502107 FC(F)(F)Oc1cccc(Nc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2Cl)c1 InChI=1S/C20H13ClF3N5OS/c21-16-10-26-19(28-17-5-4-12(9-25-17)13-6-7-31-11-13)29-18(16)27-14-2-1-3-15(8-14)30-20(22,23)24/h1-11H,(H2,25,26,27,28,29) QOCXPFRFZAKBPW-UHFFFAOYSA-N 50605246 CHEMBL5189411 Dipeptidyl peptidase 1 246 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605246 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605246&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168281643 482616097 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502108 Fc1ccc(Nc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2Cl)cc1 InChI=1S/C19H13ClFN5S/c20-16-10-23-19(26-18(16)24-15-4-2-14(21)3-5-15)25-17-6-1-12(9-22-17)13-7-8-27-11-13/h1-11H,(H2,22,23,24,25,26) OEDKOGQVVSSEPE-UHFFFAOYSA-N 50605247 CHEMBL5185056 Dipeptidyl peptidase 1 134 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605247 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605247&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168280624 482616098 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502109 Fc1ccc(Nc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2Cl)cc1C(F)(F)F InChI=1S/C20H12ClF4N5S/c21-15-9-27-19(29-17-4-1-11(8-26-17)12-5-6-31-10-12)30-18(15)28-13-2-3-16(22)14(7-13)20(23,24)25/h1-10H,(H2,26,27,28,29,30) TYQXTKKNEIPCJE-UHFFFAOYSA-N 50605248 CHEMBL5176223 Dipeptidyl peptidase 1 201 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605248 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605248&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168273633 482616099 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502110 Fc1ccc(Nc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2Cl)cc1F InChI=1S/C19H12ClF2N5S/c20-14-9-24-19(27-18(14)25-13-2-3-15(21)16(22)7-13)26-17-4-1-11(8-23-17)12-5-6-28-10-12/h1-10H,(H2,23,24,25,26,27) BTUHWQKBTYQZAJ-UHFFFAOYSA-N 50605249 CHEMBL5200608 Dipeptidyl peptidase 1 174 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605249 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605249&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168292225 482616100 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502111 FC(F)(F)c1ccc(Nc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2Cl)cc1 InChI=1S/C20H13ClF3N5S/c21-16-10-26-19(28-17-6-1-12(9-25-17)13-7-8-30-11-13)29-18(16)27-15-4-2-14(3-5-15)20(22,23)24/h1-11H,(H2,25,26,27,28,29) CNTRCGCSHPFXBU-UHFFFAOYSA-N 50605250 CHEMBL5202532 Dipeptidyl peptidase 1 150 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605250 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605250&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168293834 482616101 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502112 FC(F)(F)c1ccc(CNc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2Cl)cc1 InChI=1S/C21H15ClF3N5S/c22-17-11-28-20(29-18-6-3-14(10-26-18)15-7-8-31-12-15)30-19(17)27-9-13-1-4-16(5-2-13)21(23,24)25/h1-8,10-12H,9H2,(H2,26,27,28,29,30) RWYLAESYOQQVDV-UHFFFAOYSA-N 50605251 CHEMBL5204393 Dipeptidyl peptidase 1 92 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605251 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605251&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168293488 482616102 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502113 Nc1ccc(Nc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2Cl)cc1 InChI=1S/C19H15ClN6S/c20-16-10-23-19(26-18(16)24-15-4-2-14(21)3-5-15)25-17-6-1-12(9-22-17)13-7-8-27-11-13/h1-11H,21H2,(H2,22,23,24,25,26) YJNKDMJBFHJGJJ-UHFFFAOYSA-N 50605252 CHEMBL5196138 Dipeptidyl peptidase 1 90 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605252 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605252&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168289983 482616103 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502114 Nc1cccc(Nc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2Cl)c1 InChI=1S/C19H15ClN6S/c20-16-10-23-19(26-18(16)24-15-3-1-2-14(21)8-15)25-17-5-4-12(9-22-17)13-6-7-27-11-13/h1-11H,21H2,(H2,22,23,24,25,26) WKADYGVZEMHTGP-UHFFFAOYSA-N 50605253 CHEMBL5183337 Dipeptidyl peptidase 1 127 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605253 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605253&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168279119 482616104 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502115 CC(=O)Nc1ccc(Nc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2Cl)cc1 InChI=1S/C21H17ClN6OS/c1-13(29)25-16-3-5-17(6-4-16)26-20-18(22)11-24-21(28-20)27-19-7-2-14(10-23-19)15-8-9-30-12-15/h2-12H,1H3,(H,25,29)(H2,23,24,26,27,28) UQNZKKXJBMSBJE-UHFFFAOYSA-N 50605254 CHEMBL5201740 Dipeptidyl peptidase 1 100 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605254 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605254&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168292028 482616105 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502116 CC(=O)Nc1cccc(Nc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2Cl)c1 InChI=1S/C21H17ClN6OS/c1-13(29)25-16-3-2-4-17(9-16)26-20-18(22)11-24-21(28-20)27-19-6-5-14(10-23-19)15-7-8-30-12-15/h2-12H,1H3,(H,25,29)(H2,23,24,26,27,28) CVEIEBFUSJRUSP-UHFFFAOYSA-N 50605255 CHEMBL5186557 Dipeptidyl peptidase 1 70 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605255 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605255&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 163409160 482616106 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502117 Clc1cnc(Nc2ccc(cn2)-c2ccsc2)nc1Nc1ccccn1 InChI=1S/C18H13ClN6S/c19-14-10-22-18(25-17(14)23-15-3-1-2-7-20-15)24-16-5-4-12(9-21-16)13-6-8-26-11-13/h1-11H,(H2,20,21,22,23,24,25) SQRJFCFZLHISBO-UHFFFAOYSA-N 50605256 CHEMBL5178862 Dipeptidyl peptidase 1 155 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605256 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605256&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168276688 482616107 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502118 Clc1cnc(Nc2ccc(cn2)-c2ccsc2)nc1NC1CCNCC1 InChI=1S/C18H19ClN6S/c19-15-10-22-18(25-17(15)23-14-3-6-20-7-4-14)24-16-2-1-12(9-21-16)13-5-8-26-11-13/h1-2,5,8-11,14,20H,3-4,6-7H2,(H2,21,22,23,24,25) MZYMYTQHMMTSON-UHFFFAOYSA-N 50605257 CHEMBL5187782 Dipeptidyl peptidase 1 169 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605257 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605257&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168278253 482616108 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502119 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2-c2ccoc2)c1 InChI=1S/C24H16F3N5OS/c25-24(26,27)18-2-1-3-19(10-18)30-22-20(16-6-8-33-13-16)12-29-23(32-22)31-21-5-4-15(11-28-21)17-7-9-34-14-17/h1-14H,(H2,28,29,30,31,32) KGYNDHCZUUPUDB-UHFFFAOYSA-N 50605219 CHEMBL5172531 Dipeptidyl peptidase 1 >5000 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605219 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605219&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168271118 482616070 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502120 CN1CCC(=CC1)c1cnc(Nc2ccc(cn2)-c2ccsc2)nc1Nc1cccc(c1)C(F)(F)F InChI=1S/C26H23F3N6S/c1-35-10-7-17(8-11-35)22-15-31-25(33-23-6-5-18(14-30-23)19-9-12-36-16-19)34-24(22)32-21-4-2-3-20(13-21)26(27,28)29/h2-7,9,12-16H,8,10-11H2,1H3,(H2,30,31,32,33,34) CUUKUHWIYYAGQU-UHFFFAOYSA-N 50605221 CHEMBL5195835 Dipeptidyl peptidase 1 >5000 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605221 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605221&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168288061 482616072 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502121 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2-c2ccncc2)c1 InChI=1S/C25H17F3N6S/c26-25(27,28)19-2-1-3-20(12-19)32-23-21(16-6-9-29-10-7-16)14-31-24(34-23)33-22-5-4-17(13-30-22)18-8-11-35-15-18/h1-15H,(H2,30,31,32,33,34) QHTQRAWEYOBHEQ-UHFFFAOYSA-N 50605222 CHEMBL5174217 Dipeptidyl peptidase 1 >5000 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605222 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605222&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168273539 482616073 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502122 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2-c2ccccc2)c1 InChI=1S/C26H18F3N5S/c27-26(28,29)20-7-4-8-21(13-20)32-24-22(17-5-2-1-3-6-17)15-31-25(34-24)33-23-10-9-18(14-30-23)19-11-12-35-16-19/h1-16H,(H2,30,31,32,33,34) QMKNNEGMFCGQTO-UHFFFAOYSA-N 50605223 CHEMBL5189518 Dipeptidyl peptidase 1 >5000 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605223 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605223&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168282420 482616074 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502123 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2-c2cccc(Cl)c2)c1 InChI=1S/C26H17ClF3N5S/c27-20-5-1-3-16(11-20)22-14-32-25(34-23-8-7-17(13-31-23)18-9-10-36-15-18)35-24(22)33-21-6-2-4-19(12-21)26(28,29)30/h1-15H,(H2,31,32,33,34,35) QPRJQHAZDRLXSL-UHFFFAOYSA-N 50605225 CHEMBL5184805 Dipeptidyl peptidase 1 >5000 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605225 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605225&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168282172 482616076 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502124 NC(=O)c1cccc(c1)-c1cnc(Nc2ccc(cn2)-c2ccsc2)nc1Nc1cccc(c1)C(F)(F)F InChI=1S/C27H19F3N6OS/c28-27(29,30)20-5-2-6-21(12-20)34-25-22(16-3-1-4-17(11-16)24(31)37)14-33-26(36-25)35-23-8-7-18(13-32-23)19-9-10-38-15-19/h1-15H,(H2,31,37)(H2,32,33,34,35,36) NGACBAAYLMDCFT-UHFFFAOYSA-N 50605227 CHEMBL5208509 Dipeptidyl peptidase 1 >5000 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605227 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605227&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168297725 482616078 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502125 CC(=O)Nc1cccc(c1)-c1cnc(Nc2ccc(cn2)-c2ccsc2)nc1Nc1cccc(c1)C(F)(F)F InChI=1S/C28H21F3N6OS/c1-17(38)34-22-6-2-4-18(12-22)24-15-33-27(36-25-9-8-19(14-32-25)20-10-11-39-16-20)37-26(24)35-23-7-3-5-21(13-23)28(29,30)31/h2-16H,1H3,(H,34,38)(H2,32,33,35,36,37) HSKMGPMYKVEFJG-UHFFFAOYSA-N 50605229 CHEMBL5202703 Dipeptidyl peptidase 1 >5000 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605229 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605229&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168293939 482616080 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502126 CS(=O)(=O)c1ccc(cc1)-c1cnc(Nc2ccc(cn2)-c2ccsc2)nc1Nc1cccc(c1)C(F)(F)F InChI=1S/C27H20F3N5O2S2/c1-39(36,37)22-8-5-17(6-9-22)23-15-32-26(34-24-10-7-18(14-31-24)19-11-12-38-16-19)35-25(23)33-21-4-2-3-20(13-21)27(28,29)30/h2-16H,1H3,(H2,31,32,33,34,35) XGEXNSZQWMYMCU-UHFFFAOYSA-N 50605231 CHEMBL5176848 Dipeptidyl peptidase 1 >5000 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605231 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605231&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168276563 482616082 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502127 Nc1ccc(cc1)-c1cnc(Nc2ccc(cn2)-c2ccsc2)nc1Nc1cccc(c1)C(F)(F)F InChI=1S/C26H19F3N6S/c27-26(28,29)19-2-1-3-21(12-19)33-24-22(16-4-7-20(30)8-5-16)14-32-25(35-24)34-23-9-6-17(13-31-23)18-10-11-36-15-18/h1-15H,30H2,(H2,31,32,33,34,35) KMGCPKDAPLNDRR-UHFFFAOYSA-N 50605232 CHEMBL5176578 Dipeptidyl peptidase 1 >5000 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605232 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605232&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168272562 482616083 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502128 CN1CCN(CC1)c1ccc(cc1)-c1cnc(Nc2ccc(cn2)-c2ccsc2)nc1Nc1cccc(c1)C(F)(F)F InChI=1S/C31H28F3N7S/c1-40-12-14-41(15-13-40)26-8-5-21(6-9-26)27-19-36-30(38-28-10-7-22(18-35-28)23-11-16-42-20-23)39-29(27)37-25-4-2-3-24(17-25)31(32,33)34/h2-11,16-20H,12-15H2,1H3,(H2,35,36,37,38,39) XYOHWVORCBBKOF-UHFFFAOYSA-N 50605233 CHEMBL5198107 Dipeptidyl peptidase 1 >5000 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605233 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605233&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168289065 482616084 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502129 CN1CCN(Cc2ccc(cc2)-c2cnc(Nc3ccc(cn3)-c3ccsc3)nc2Nc2cccc(c2)C(F)(F)F)CC1 InChI=1S/C32H30F3N7S/c1-41-12-14-42(15-13-41)20-22-5-7-23(8-6-22)28-19-37-31(39-29-10-9-24(18-36-29)25-11-16-43-21-25)40-30(28)38-27-4-2-3-26(17-27)32(33,34)35/h2-11,16-19,21H,12-15,20H2,1H3,(H2,36,37,38,39,40) RJKKBSVUDSLXMC-UHFFFAOYSA-N 50605234 CHEMBL5186113 Dipeptidyl peptidase 1 >5000 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605234 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605234&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168282652 482616085 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502130 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(cc3)-c3ccsc3)ncc2Cl)c1 InChI=1S/C21H14ClF3N4S/c22-18-11-26-20(28-16-6-4-13(5-7-16)14-8-9-30-12-14)29-19(18)27-17-3-1-2-15(10-17)21(23,24)25/h1-12H,(H2,26,27,28,29) RHCGVRDKBMISGQ-UHFFFAOYSA-N 50605235 CHEMBL5191730 Dipeptidyl peptidase 1 >5000 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605235&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168288277 482616086 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502131 FC(F)(F)c1cccc(Nc2nc(Nc3ncc(cn3)-c3ccsc3)ncc2Cl)c1 InChI=1S/C19H12ClF3N6S/c20-15-9-26-18(29-17-24-7-12(8-25-17)11-4-5-30-10-11)28-16(15)27-14-3-1-2-13(6-14)19(21,22)23/h1-10H,(H2,24,25,26,27,28,29) ZEUPIZNEEJEXDH-UHFFFAOYSA-N 50605237 CHEMBL5173569 Dipeptidyl peptidase 1 >5000 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605237 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605237&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168272458 482616088 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502132 FC(F)(F)c1cccc(Nc2nc(Nc3cnc(cn3)-c3ccsc3)ncc2Cl)c1 InChI=1S/C19H12ClF3N6S/c20-14-7-26-18(28-16-9-24-15(8-25-16)11-4-5-30-10-11)29-17(14)27-13-3-1-2-12(6-13)19(21,22)23/h1-10H,(H2,25,26,27,28,29) GBXRXXFHYLQEKQ-UHFFFAOYSA-N 50605238 CHEMBL5175900 Dipeptidyl peptidase 1 >5000 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605238 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605238&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168273070 482616089 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51502133 FC(F)(F)c1cccc(Nc2nc(Nc3ccc(cn3)-c3ccco3)ncc2Cl)c1 InChI=1S/C20H13ClF3N5O/c21-15-11-26-19(28-17-7-6-12(10-25-17)16-5-2-8-30-16)29-18(15)27-14-4-1-3-13(9-14)20(22,23)24/h1-11H,(H2,25,26,27,28,29) ZPXVVWBRFQBCJI-UHFFFAOYSA-N 50605243 CHEMBL5179212 Dipeptidyl peptidase 1 >5000 ChEMBL 10.7270/Q22R3WRK 35429909 Chen, X; Yan, Y; Du, J; Shen, X; He, C; Pan, H; Zhu, J; Liu, X Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605243 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605243&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 168276699 482616094 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51513192 C[C@@H](O)[C@H](N)C(=O)N[C@H](CCC(O)=O)\C=C\S(C)(=O)=O InChI=1S/C11H20N2O6S/c1-7(14)10(12)11(17)13-8(3-4-9(15)16)5-6-20(2,18)19/h5-8,10,14H,3-4,12H2,1-2H3,(H,13,17)(H,15,16)/b6-5+/t7-,8-,10+/m1/s1 KOVSURHHZKAEKF-XWBFIUNOSA-N 50609007 CHEMBL5290773 Dipeptidyl peptidase 1 4900 ChEMBL 10.7270/Q2PZ5F16 34492551 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50609007 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50609007&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171358095 494498755 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51513193 NCC(=O)N[C@@H](Cc1ccccc1)C(=O)[CH-][N+]#N InChI=1S/C12H14N4O2/c13-7-12(18)16-10(11(17)8-15-14)6-9-4-2-1-3-5-9/h1-5,8,10H,6-7,13H2,(H,16,18)/t10-/m0/s1 CBOIZHHBFFTMCQ-JTQLQIEISA-N 50270030 2-Amino-N-((S)-1-benzyl-3-diazo-2-oxo-propyl)-acetamide::CHEMBL448143 Dipeptidyl peptidase 1 50 ChEMBL 10.7270/Q2PZ5F16 34492551 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50270030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50270030&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 44584933 104115409 CHEMBL448143 ZINC13519194 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51513194 NCC(=O)N[C@@H](Cc1ccc(I)cc1)C(=O)[CH-][N+]#N InChI=1S/C12H13IN4O2/c13-9-3-1-8(2-4-9)5-10(11(18)7-16-15)17-12(19)6-14/h1-4,7,10H,5-6,14H2,(H,17,19)/t10-/m0/s1 IVMLSILVSGOWGN-JTQLQIEISA-N 50270029 2-Amino-N-[(S)-3-diazo-1-(4-iodo-benzyl)-2-oxo-propyl]-acetamide::CHEMBL450997 Dipeptidyl peptidase 1 1.000000 ChEMBL 10.7270/Q2PZ5F16 34492551 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50270029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50270029&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 44584931 104115408 CHEMBL450997 ZINC40980476 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51513195 CC(C)CC(NC(=O)CN)P(O)(=O)CCC(O)=O InChI=1S/C10H21N2O5P/c1-7(2)5-9(12-8(13)6-11)18(16,17)4-3-10(14)15/h7,9H,3-6,11H2,1-2H3,(H,12,13)(H,14,15)(H,16,17) KCDGZFXIALQQSR-UHFFFAOYSA-N 50147181 3-{[1-(2-Amino-acetylamino)-3-methyl-butyl]-hydroxy-phosphinoyl}-propionic acid; hydrochloride::CHEMBL543631 Dipeptidyl peptidase 1 39000 ChEMBL 10.7270/Q2PZ5F16 34492551 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50147181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50147181&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 10333861 104035702 CHEMBL543631 ZINC26839865 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51513196 CC[C@H](NC(=O)C1(C)CCOCC1)\C=C\C(=O)N1CCc2ccccc12 InChI=1S/C21H28N2O3/c1-3-17(22-20(25)21(2)11-14-26-15-12-21)8-9-19(24)23-13-10-16-6-4-5-7-18(16)23/h4-9,17H,3,10-15H2,1-2H3,(H,22,25)/b9-8+/t17-/m0/s1 HKSAQYQFICXXJS-IJDCCNJMSA-N 50609008 CHEMBL5269225 Dipeptidyl peptidase 1 1.000000 ChEMBL 10.7270/Q2PZ5F16 34492551 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50609008 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50609008&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171342237 494498756 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 51513197 Fc1ccc(Nc2ncnc3cc(OCCCN4CCOCC4)c(NC(=O)C=C)cc23)cc1Cl InChI=1S/C24H25ClFN5O3/c1-2-23(32)30-21-13-17-20(14-22(21)34-9-3-6-31-7-10-33-11-8-31)27-15-28-24(17)29-16-4-5-19(26)18(25)12-16/h2,4-5,12-15H,1,3,6-11H2,(H,30,32)(H,27,28,29) OMZCMEYTWSXEPZ-UHFFFAOYSA-N 4779 CHEMBL31965::CHEMBL545315::CI-1033::Canertinib::N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(morpholin-4-yl)propoxy]quinazolin-6-yl}prop-2-enamide::PD0183805::US10507209, Compound CI-1033::US9730934, CI-1033::cid_156414 Dipeptidyl peptidase 1 120 ChEMBL 10.7270/Q2PZ5F16 34492551 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4779&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 156414 8034429 61399 CHEMBL31965CHEMBL545315 DB05424 5675 ZINC27439698 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1347524 Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)c(F)c1 InChI=1S/C23H23FN4O4/c1-28-19-11-15(5-6-20(19)32-23(28)30)14-3-4-16(18(24)10-14)9-17(12-25)27-22(29)21-13-26-7-2-8-31-21/h3-6,10-11,17,21,26H,2,7-9,13H2,1H3,(H,27,29)/t17-,21-/m0/s1 ONJDRXNRBKHINH-UWJYYQICSA-N 633575 (S)—N—((S)-1-cyano-2-(2-fluoro-4-(3-methyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)phenyl)ethyl)-1,4-oxazepane-2-carboxamide ::US11807635, Compound 1 Dipeptidyl peptidase 1 1.60 US Patent 10.7270/Q2CF9V8V US11807635 Li, Y; Shi, Z; Zhang, G; Chen, L; Wang, W; Zhang, X; Zheng, D; Xu, B; Liu, X; Wang, Y; Ye, F; Tang, P; Ni, J; Zhang, C; Yan, P Haisco Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=633575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=633575&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1347525 Fc1cc(ccc1C[C@H](NC(=O)[C@@H]1CNCCCO1)C#N)-c1ccc2C(=O)NCCc2c1 InChI=1S/C24H25FN4O3/c25-21-12-16(15-4-5-20-17(10-15)6-8-28-23(20)30)2-3-18(21)11-19(13-26)29-24(31)22-14-27-7-1-9-32-22/h2-5,10,12,19,22,27H,1,6-9,11,14H2,(H,28,30)(H,29,31)/t19-,22-/m0/s1 NDGCEPISOMNOTH-UGKGYDQZSA-N 633576 (S)—N—((S)-1-cyano-2-(2-fluoro-4-(1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl)phenyl)ethyl)-1,4-oxazepane-2-carboxamide ::US11807635, Compound 10 Dipeptidyl peptidase 1 6.70 US Patent 10.7270/Q2CF9V8V US11807635 Li, Y; Shi, Z; Zhang, G; Chen, L; Wang, W; Zhang, X; Zheng, D; Xu, B; Liu, X; Wang, Y; Ye, F; Tang, P; Ni, J; Zhang, C; Yan, P Haisco Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=633576 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=633576&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1347526 Fc1cc(ccc1C[C@H](NC(=O)[C@@H]1CNCCCO1)C#N)C#CC1CCCC1 InChI=1S/C22H26FN3O2/c23-20-12-17(7-6-16-4-1-2-5-16)8-9-18(20)13-19(14-24)26-22(27)21-15-25-10-3-11-28-21/h8-9,12,16,19,21,25H,1-5,10-11,13,15H2,(H,26,27)/t19-,21-/m0/s1 YYNWOCFMAXNUQD-FPOVZHCZSA-N 633577 (S)—N—((S)-1-cyano-2-(4-(cyclopentylethynyl)-2-fluorophenyl)ethyl)-1,4-oxazepane-2-carboxamide ::US11807635, Compound 11 Dipeptidyl peptidase 1 239 US Patent 10.7270/Q2CF9V8V US11807635 Li, Y; Shi, Z; Zhang, G; Chen, L; Wang, W; Zhang, X; Zheng, D; Xu, B; Liu, X; Wang, Y; Ye, F; Tang, P; Ni, J; Zhang, C; Yan, P Haisco Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=633577 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=633577&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1347527 Cc1nc(sc1C#N)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)c(F)c1 InChI=1S/C20H20FN5O2S/c1-12-18(10-23)29-20(25-12)14-4-3-13(16(21)8-14)7-15(9-22)26-19(27)17-11-24-5-2-6-28-17/h3-4,8,15,17,24H,2,5-7,11H2,1H3,(H,26,27)/t15-,17-/m0/s1 DZPWZIJPLDTZSR-RDJZCZTQSA-N 633578 (S)—N—((S)-1-cyano-2-(4-(5-cyano-4-methylthiazol-2-yl)-2-fluorophenyl)ethyl)-1,4-oxazepane-2-carboxamide ::US11807635, Compound 12 Dipeptidyl peptidase 1 21.0 US Patent 10.7270/Q2CF9V8V US11807635 Li, Y; Shi, Z; Zhang, G; Chen, L; Wang, W; Zhang, X; Zheng, D; Xu, B; Liu, X; Wang, Y; Ye, F; Tang, P; Ni, J; Zhang, C; Yan, P Haisco Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=633578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=633578&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1347528 Fc1cc(ccc1C[C@H](NC(=O)[C@@H]1CNCCCO1)C#N)-c1nc2ccccc2s1 InChI=1S/C22H21FN4O2S/c23-17-11-15(22-27-18-4-1-2-5-20(18)30-22)7-6-14(17)10-16(12-24)26-21(28)19-13-25-8-3-9-29-19/h1-2,4-7,11,16,19,25H,3,8-10,13H2,(H,26,28)/t16-,19-/m0/s1 LRKSJEGYMMRIAI-LPHOPBHVSA-N 633579 (S)—N—((S)-2-(4-(benzo[d]thiazol-2-yl)-2-fluorophenyl)-1-cyanoethyl)-1,4-oxazepane-2-carboxamide ::US11807635, Compound 13 Dipeptidyl peptidase 1 71.0 US Patent 10.7270/Q2CF9V8V US11807635 Li, Y; Shi, Z; Zhang, G; Chen, L; Wang, W; Zhang, X; Zheng, D; Xu, B; Liu, X; Wang, Y; Ye, F; Tang, P; Ni, J; Zhang, C; Yan, P Haisco Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=633579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=633579&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1347529 CN1CCN(Cc2ccc(cc2)-c2ccc(C[C@H](NC(=O)C3CNCCCO3)C#N)c(F)c2)CC1 InChI=1S/C27H34FN5O2/c1-32-10-12-33(13-11-32)19-20-3-5-21(6-4-20)22-7-8-23(25(28)16-22)15-24(17-29)31-27(34)26-18-30-9-2-14-35-26/h3-8,16,24,26,30H,2,9-15,18-19H2,1H3,(H,31,34)/t24-,26?/m0/s1 AQDCRYRTBBMGDG-QSAPEBAKSA-N 633580 (S)—N—((S)-1-cyano-2-(3-fluoro-4′-((4-methylpiperazin-1-yl)methyl)-[1,1′-biphenyl]-4-yl)ethyl)-1,4-oxazepane-2-carboxamide ::US11807635, Compound 14 Dipeptidyl peptidase 1 12.9 US Patent 10.7270/Q2CF9V8V US11807635 Li, Y; Shi, Z; Zhang, G; Chen, L; Wang, W; Zhang, X; Zheng, D; Xu, B; Liu, X; Wang, Y; Ye, F; Tang, P; Ni, J; Zhang, C; Yan, P Haisco Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=633580 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=633580&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1347530 Cc1csc(n1)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)c(F)c1 InChI=1S/C19H21FN4O2S/c1-12-11-27-19(23-12)14-4-3-13(16(20)8-14)7-15(9-21)24-18(25)17-10-22-5-2-6-26-17/h3-4,8,11,15,17,22H,2,5-7,10H2,1H3,(H,24,25)/t15-,17-/m0/s1 UUDIXOZBJSMBSJ-RDJZCZTQSA-N 633581 (S)—N—((S)-1-cyano-2-(2-fluoro-4-(4-methylthiazol-2-yl)phenyl)ethyl)-1,4-oxazepane-2-carboxamide ::US11807635, Compound 15 Dipeptidyl peptidase 1 33.0 US Patent 10.7270/Q2CF9V8V US11807635 Li, Y; Shi, Z; Zhang, G; Chen, L; Wang, W; Zhang, X; Zheng, D; Xu, B; Liu, X; Wang, Y; Ye, F; Tang, P; Ni, J; Zhang, C; Yan, P Haisco Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=633581 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=633581&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1347531 Fc1cc(ccc1C[C@H](NC(=O)[C@@H]1CNCCCO1)C#N)-c1ccc(C#N)c(c1)C1CC1 InChI=1S/C25H25FN4O2/c26-23-12-18(17-5-7-20(13-27)22(11-17)16-2-3-16)4-6-19(23)10-21(14-28)30-25(31)24-15-29-8-1-9-32-24/h4-7,11-12,16,21,24,29H,1-3,8-10,15H2,(H,30,31)/t21-,24-/m0/s1 JUGMPIVXWMMEIG-URXFXBBRSA-N 633582 (S)—N—((S)-1-cyano-2-(4′-cyano-3′-cyclopropyl-3-fluoro-[1,1′-biphenyl]-4-yl)ethyl)-1,4-oxazepane-2-carboxamide ::US11807635, Compound 17 Dipeptidyl peptidase 1 7.40 US Patent 10.7270/Q2CF9V8V US11807635 Li, Y; Shi, Z; Zhang, G; Chen, L; Wang, W; Zhang, X; Zheng, D; Xu, B; Liu, X; Wang, Y; Ye, F; Tang, P; Ni, J; Zhang, C; Yan, P Haisco Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=633582 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=633582&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1347532 Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)c(F)c1 InChI=1S/C23H23FN4O4/c1-28-19-11-15(5-6-20(19)32-23(28)30)14-3-4-16(18(24)10-14)9-17(12-25)27-22(29)21-13-26-7-2-8-31-21/h3-6,10-11,17,21,26H,2,7-9,13H2,1H3,(H,27,29)/t17-,21-/m0/s1 ONJDRXNRBKHINH-UWJYYQICSA-N 633583 (S)—N—((S)-1-cyano-2-(2-fluoro-4-(3-(methyl-d3)-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)phenyl) ethyl)-1,4-oxazepane-2-carboxamide ::US11807635, Compound 23 Dipeptidyl peptidase 1 0.500 US Patent 10.7270/Q2CF9V8V US11807635 Li, Y; Shi, Z; Zhang, G; Chen, L; Wang, W; Zhang, X; Zheng, D; Xu, B; Liu, X; Wang, Y; Ye, F; Tang, P; Ni, J; Zhang, C; Yan, P Haisco Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=633583 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=633583&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1347533 Fc1cc(ccc1C[C@H](NC(=O)[C@@H]1CNCCCO1)C#N)-c1ccc(C#N)c(c1)C(F)(F)F InChI=1S/C23H20F4N4O2/c24-20-10-15(14-3-5-17(11-28)19(9-14)23(25,26)27)2-4-16(20)8-18(12-29)31-22(32)21-13-30-6-1-7-33-21/h2-5,9-10,18,21,30H,1,6-8,13H2,(H,31,32)/t18-,21-/m0/s1 MWWUHXUNMKLEMV-RXVVDRJESA-N 633584 (S)—N—((S)-1-cyano-2-(4′-cyano-3-fluoro-3′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)ethyl)-1,4-oxazepane-2-carboxamide ::US11807635, Compound 29 Dipeptidyl peptidase 1 4.90 US Patent 10.7270/Q2CF9V8V US11807635 Li, Y; Shi, Z; Zhang, G; Chen, L; Wang, W; Zhang, X; Zheng, D; Xu, B; Liu, X; Wang, Y; Ye, F; Tang, P; Ni, J; Zhang, C; Yan, P Haisco Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=633584 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=633584&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1347534 Cn1c2cc(ccc2oc1=O)-c1cc(F)c(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cn1 InChI=1S/C22H22FN5O4/c1-28-18-8-13(3-4-19(18)32-22(28)30)17-9-16(23)14(11-26-17)7-15(10-24)27-21(29)20-12-25-5-2-6-31-20/h3-4,8-9,11,15,20,25H,2,5-7,12H2,1H3,(H,27,29)/t15-,20-/m0/s1 UAMQZZHEAQSCEG-YWZLYKJASA-N 633585 US11807635, Compound 35 Dipeptidyl peptidase 1 4.00 US Patent 10.7270/Q2CF9V8V US11807635 Li, Y; Shi, Z; Zhang, G; Chen, L; Wang, W; Zhang, X; Zheng, D; Xu, B; Liu, X; Wang, Y; Ye, F; Tang, P; Ni, J; Zhang, C; Yan, P Haisco Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=633585 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=633585&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1347535 CO[C@@H]1CNC[C@H](OC1)C(=O)N[C@@H](Cc1ccc(cc1F)-c1ccc(cc1)S(F)(F)(F)(F)F)C#N InChI=1S/C22H23F6N3O3S/c1-33-18-11-30-12-21(34-13-18)22(32)31-17(10-29)8-16-3-2-15(9-20(16)23)14-4-6-19(7-5-14)35(24,25,26,27)28/h2-7,9,17-18,21,30H,8,11-13H2,1H3,(H,31,32)/t17-,18+,21-/m0/s1 CSJMBCKPDWJOCO-UEXGIBASSA-N 633586 N—((S)-1-cyano-2-(3-fluoro-4′-(pentafluoro-16-sulfanyl)-[1,1′-biphenyl]-4-yl)ethyl)-6-methoxy-1,4-oxazepane-2-carboxamide ::US11807635, Compound 43 Dipeptidyl peptidase 1 0.300 US Patent 10.7270/Q2CF9V8V US11807635 Li, Y; Shi, Z; Zhang, G; Chen, L; Wang, W; Zhang, X; Zheng, D; Xu, B; Liu, X; Wang, Y; Ye, F; Tang, P; Ni, J; Zhang, C; Yan, P Haisco Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=633586 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=633586&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1411691 Cn1ncc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H25N5O2/c1-28-21-12-18(7-8-19(21)14-26-28)17-5-3-16(4-6-17)11-20(13-24)27-23(29)22-15-25-9-2-10-30-22/h3-8,12,14,20,22,25H,2,9-11,15H2,1H3,(H,27,29)/t20-,22-/m0/s1 MZHADPYRPLGVDH-UNMCSNQZSA-N 674376 US20240150335, Compound 2 Dipeptidyl peptidase 1 Homo sapiens 26.8 US Patent 10.7270/Q2X06CCR US20240150335 WU, L; ZHAO, L; CHEN, D; YAN, X; CHEN, S Medshine Discovery http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=674376 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=674376&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171466630 497643726 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1411692 Cn1nnc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C22H24N6O2/c1-28-20-12-17(7-8-19(20)26-27-28)16-5-3-15(4-6-16)11-18(13-23)25-22(29)21-14-24-9-2-10-30-21/h3-8,12,18,21,24H,2,9-11,14H2,1H3,(H,25,29)/t18-,21-/m0/s1 HNIKVEISKRIEER-RXVVDRJESA-N 674377 US20240150335, Compound 4 Dipeptidyl peptidase 1 Homo sapiens 10.8 US Patent 10.7270/Q2X06CCR US20240150335 WU, L; ZHAO, L; CHEN, D; YAN, X; CHEN, S Medshine Discovery http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=674377 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=674377&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171466687 497643727 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1411693 CN1Cc2cc(ccc2C1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H26N4O3/c1-28-15-19-12-18(7-8-21(19)24(28)30)17-5-3-16(4-6-17)11-20(13-25)27-23(29)22-14-26-9-2-10-31-22/h3-8,12,20,22,26H,2,9-11,14-15H2,1H3,(H,27,29)/t20-,22-/m0/s1 VUAUEPHRGUBJAZ-UNMCSNQZSA-N 674378 US20240150335, Compound 5 Dipeptidyl peptidase 1 Homo sapiens 28.3 US Patent 10.7270/Q2X06CCR US20240150335 WU, L; ZHAO, L; CHEN, D; YAN, X; CHEN, S Medshine Discovery http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=674378 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=674378&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171466609 497643728 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1411694 Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)c(F)c1 InChI=1S/C23H23FN4O4/c1-28-19-11-15(5-6-20(19)32-23(28)30)14-3-4-16(18(24)10-14)9-17(12-25)27-22(29)21-13-26-7-2-8-31-21/h3-6,10-11,17,21,26H,2,7-9,13H2,1H3,(H,27,29)/t17-,21-/m0/s1 ONJDRXNRBKHINH-UWJYYQICSA-N 633575 (S) N ((S)-1-cyano-2-(2-fluoro-4-(3-methyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)phenyl)ethyl)-1,4-oxazepane-2-carboxamide ::US11807635, Compound 1::US20240150335, Compound 6 Dipeptidyl peptidase 1 Homo sapiens 0.840 US Patent 10.7270/Q2X06CCR US20240150335 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=633575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=633575&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 162738687 486499289 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1411695 Cn1nnc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)c(F)c1 InChI=1S/C22H23FN6O2/c1-29-20-11-15(5-6-19(20)27-28-29)14-3-4-16(18(23)10-14)9-17(12-24)26-22(30)21-13-25-7-2-8-31-21/h3-6,10-11,17,21,25H,2,7-9,13H2,1H3,(H,26,30)/t17-,21-/m0/s1 LWCXISFRDQHNRG-UWJYYQICSA-N 674380 US20240150335, Compound 7 Dipeptidyl peptidase 1 Homo sapiens 2.52 US Patent 10.7270/Q2X06CCR US20240150335 WU, L; ZHAO, L; CHEN, D; YAN, X; CHEN, S Medshine Discovery http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=674380 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=674380&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171466596 497643730 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1411696 Cn1ncc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)c(F)c1 InChI=1S/C23H24FN5O2/c1-29-21-11-16(4-6-18(21)13-27-29)15-3-5-17(20(24)10-15)9-19(12-25)28-23(30)22-14-26-7-2-8-31-22/h3-6,10-11,13,19,22,26H,2,7-9,14H2,1H3,(H,28,30)/t19-,22-/m0/s1 IVFUIEQQJAEOCC-UGKGYDQZSA-N 674381 US20240150335, Compound 8 Dipeptidyl peptidase 1 Homo sapiens 3.57 US Patent 10.7270/Q2X06CCR US20240150335 WU, L; ZHAO, L; CHEN, D; YAN, X; CHEN, S Medshine Discovery http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=674381 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=674381&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171466655 497643731 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1411697 CC(C)n1ncc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C25H29N5O2/c1-17(2)30-23-13-20(8-9-21(23)15-28-30)19-6-4-18(5-7-19)12-22(14-26)29-25(31)24-16-27-10-3-11-32-24/h4-9,13,15,17,22,24,27H,3,10-12,16H2,1-2H3,(H,29,31)/t22-,24-/m0/s1 HPJYAYNZPQSWGG-UPVQGACJSA-N 674382 US20240150335, Compound 9 Dipeptidyl peptidase 1 Homo sapiens 14.0 US Patent 10.7270/Q2X06CCR US20240150335 WU, L; ZHAO, L; CHEN, D; YAN, X; CHEN, S Medshine Discovery http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=674382 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=674382&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171466679 497643732 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1411698 CC(C)n1ncc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)c(F)c1 InChI=1S/C25H28FN5O2/c1-16(2)31-23-12-18(5-7-20(23)14-29-31)17-4-6-19(22(26)11-17)10-21(13-27)30-25(32)24-15-28-8-3-9-33-24/h4-7,11-12,14,16,21,24,28H,3,8-10,15H2,1-2H3,(H,30,32)/t21-,24-/m0/s1 ZZPRBWGGFQRCSH-URXFXBBRSA-N 674383 US20240150335, Compound 10 Dipeptidyl peptidase 1 Homo sapiens 4.39 US Patent 10.7270/Q2X06CCR US20240150335 WU, L; ZHAO, L; CHEN, D; YAN, X; CHEN, S Medshine Discovery http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=674383 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=674383&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171466612 497643733 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1411699 Fc1cc(ccc1C[C@H](NC(=O)[C@@H]1CNCCCO1)C#N)-c1ccc2cnn(C3CCOCC3)c2c1 InChI=1S/C27H30FN5O3/c28-24-13-18(19-3-5-21-16-31-33(25(21)14-19)23-6-10-35-11-7-23)2-4-20(24)12-22(15-29)32-27(34)26-17-30-8-1-9-36-26/h2-5,13-14,16,22-23,26,30H,1,6-12,17H2,(H,32,34)/t22-,26-/m0/s1 DBKAJGGNUTXWPE-NVQXNPDNSA-N 674384 US20240150335, Compound 12 Dipeptidyl peptidase 1 Homo sapiens 2.38 US Patent 10.7270/Q2X06CCR US20240150335 WU, L; ZHAO, L; CHEN, D; YAN, X; CHEN, S Medshine Discovery http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=674384 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=674384&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171466603 497643734 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1411700 Fc1cc(ccc1C[C@H](NC(=O)[C@@H]1CNCCCO1)C#N)-c1ccc2nccn2c1 InChI=1S/C22H22FN5O2/c23-19-11-15(17-4-5-21-26-7-8-28(21)14-17)2-3-16(19)10-18(12-24)27-22(29)20-13-25-6-1-9-30-20/h2-5,7-8,11,14,18,20,25H,1,6,9-10,13H2,(H,27,29)/t18-,20-/m0/s1 HTAFAXQYBAZYKM-ICSRJNTNSA-N 674385 US20240150335, Compound 13 Dipeptidyl peptidase 1 Homo sapiens 20.4 US Patent 10.7270/Q2X06CCR US20240150335 WU, L; ZHAO, L; CHEN, D; YAN, X; CHEN, S Medshine Discovery http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=674385 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=674385&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171466616 497643735 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1411701 Fc1cc(ccc1C[C@@H](NC(=O)[C@@H]1CNCCCO1)C#N)-c1ccc2nccn2c1 InChI=1S/C22H22FN5O2/c23-19-11-15(17-4-5-21-26-7-8-28(21)14-17)2-3-16(19)10-18(12-24)27-22(29)20-13-25-6-1-9-30-20/h2-5,7-8,11,14,18,20,25H,1,6,9-10,13H2,(H,27,29)/t18-,20+/m1/s1 HTAFAXQYBAZYKM-QUCCMNQESA-N 674386 US20240150335, Compound 14 Dipeptidyl peptidase 1 Homo sapiens 28.1 US Patent 10.7270/Q2X06CCR US20240150335 WU, L; ZHAO, L; CHEN, D; YAN, X; CHEN, S Medshine Discovery http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=674386 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=674386&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171466634 497643736 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1411702 CN1CCOc2ccc(cc12)-c1ccc(C[C@@H](NC(=O)[C@@H]2CNCCCO2)C#N)c(F)c1 InChI=1S/C24H27FN4O3/c1-29-8-10-32-22-6-5-17(13-21(22)29)16-3-4-18(20(25)12-16)11-19(14-26)28-24(30)23-15-27-7-2-9-31-23/h3-6,12-13,19,23,27H,2,7-11,15H2,1H3,(H,28,30)/t19-,23+/m1/s1 VERYXWLIVJDFDA-XXBNENTESA-N 674387 US20240150335, Compound 15 Dipeptidyl peptidase 1 Homo sapiens 3.65 US Patent 10.7270/Q2X06CCR US20240150335 WU, L; ZHAO, L; CHEN, D; YAN, X; CHEN, S Medshine Discovery http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=674387 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=674387&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171466598 497643737 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1411703 Cn1ncc2ccc(cc12)-c1ccc(C[C@@H](NC(=O)[C@@H]2CNCCCO2)C#N)c(Cl)c1 InChI=1S/C23H24ClN5O2/c1-29-21-11-16(4-6-18(21)13-27-29)15-3-5-17(20(24)10-15)9-19(12-25)28-23(30)22-14-26-7-2-8-31-22/h3-6,10-11,13,19,22,26H,2,7-9,14H2,1H3,(H,28,30)/t19-,22+/m1/s1 YSQKFFSOOPJHED-KNQAVFIVSA-N 674388 US20240150335, Compound 16 Dipeptidyl peptidase 1 Homo sapiens 9.18 US Patent 10.7270/Q2X06CCR US20240150335 WU, L; ZHAO, L; CHEN, D; YAN, X; CHEN, S Medshine Discovery http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=674388 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=674388&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171918770 497643738 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1411704 Cc1cc(ccc1C[C@@H](NC(=O)[C@@H]1CNCCCO1)C#N)-c1ccc2cnn(C)c2c1 InChI=1S/C24H27N5O2/c1-16-10-18(19-6-7-20-14-27-29(2)22(20)12-19)5-4-17(16)11-21(13-25)28-24(30)23-15-26-8-3-9-31-23/h4-7,10,12,14,21,23,26H,3,8-9,11,15H2,1-2H3,(H,28,30)/t21-,23+/m1/s1 AHSFMYPNUZKGEL-GGAORHGYSA-N 674389 US20240150335, Compound 17 Dipeptidyl peptidase 1 Homo sapiens 22.5 US Patent 10.7270/Q2X06CCR US20240150335 WU, L; ZHAO, L; CHEN, D; YAN, X; CHEN, S Medshine Discovery http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=674389 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=674389&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171918771 497643739 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1411705 Cn1nc(F)c2ccc(cc12)-c1ccc(C[C@@H](NC(=O)[C@@H]2CNCCCO2)C#N)c(F)c1 InChI=1S/C23H23F2N5O2/c1-30-20-11-15(5-6-18(20)22(25)29-30)14-3-4-16(19(24)10-14)9-17(12-26)28-23(31)21-13-27-7-2-8-32-21/h3-6,10-11,17,21,27H,2,7-9,13H2,1H3,(H,28,31)/t17-,21+/m1/s1 IETHEQXTUYHTEC-UTKZUKDTSA-N 674390 US20240150335, Compound 18 Dipeptidyl peptidase 1 Homo sapiens 1.23 US Patent 10.7270/Q2X06CCR US20240150335 WU, L; ZHAO, L; CHEN, D; YAN, X; CHEN, S Medshine Discovery http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=674390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=674390&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171466659 497643740 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1411706 Fc1cc(ccc1C[C@@H](NC(=O)[C@@H]1CNCCCO1)C#N)-c1cc(F)c2cn[nH]c2c1 674391 US20240150335, Compound 19 Dipeptidyl peptidase 1 Homo sapiens 4.55 US Patent 10.7270/Q2X06CCR US20240150335 WU, L; ZHAO, L; CHEN, D; YAN, X; CHEN, S Medshine Discovery http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=674391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=674391&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171918772 497643741 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1411707 Cn1ncc2ncc(cc12)-c1ccc(C[C@@H](NC(=O)[C@@H]2CNCCCO2)C#N)c(F)c1 InChI=1S/C22H23FN6O2/c1-29-20-9-16(11-26-19(20)12-27-29)14-3-4-15(18(23)8-14)7-17(10-24)28-22(30)21-13-25-5-2-6-31-21/h3-4,8-9,11-12,17,21,25H,2,5-7,13H2,1H3,(H,28,30)/t17-,21+/m1/s1 MTCCJVYRRFEOLX-UTKZUKDTSA-N 674392 US20240150335, Compound 20 Dipeptidyl peptidase 1 Homo sapiens 11.5 US Patent 10.7270/Q2X06CCR US20240150335 WU, L; ZHAO, L; CHEN, D; YAN, X; CHEN, S Medshine Discovery http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=674392 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=674392&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171918773 497643742 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1411708 Fc1cc(ccc1C[C@@H](NC(=O)[C@@H]1CNCCCO1)C#N)-c1cnc2cc[nH]c2c1 674393 US20240150335, Compound 21 Dipeptidyl peptidase 1 Homo sapiens 17.3 US Patent 10.7270/Q2X06CCR US20240150335 WU, L; ZHAO, L; CHEN, D; YAN, X; CHEN, S Medshine Discovery http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=674393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=674393&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171918774 497643743 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1411709 Fc1cc(ccc1C[C@@H](NC(=O)[C@@H]1CNCCCO1)C#N)-c1ccc2cnn(C3CCNCC3)c2c1 InChI=1S/C27H31FN6O2/c28-24-13-18(19-3-5-21-16-32-34(25(21)14-19)23-6-9-30-10-7-23)2-4-20(24)12-22(15-29)33-27(35)26-17-31-8-1-11-36-26/h2-5,13-14,16,22-23,26,30-31H,1,6-12,17H2,(H,33,35)/t22-,26+/m1/s1 AEAFRCGHGCCXCQ-GJZUVCINSA-N 674394 US20240150335, Compound 22 Dipeptidyl peptidase 1 Homo sapiens 0.760 US Patent 10.7270/Q2X06CCR US20240150335 WU, L; ZHAO, L; CHEN, D; YAN, X; CHEN, S Medshine Discovery http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=674394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=674394&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171466618 497643744 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1411710 CN1CCC(CC1)n1ncc2ccc(cc12)-c1ccc(C[C@@H](NC(=O)[C@@H]2CNCCCO2)C#N)c(F)c1 InChI=1S/C28H33FN6O2/c1-34-10-7-24(8-11-34)35-26-15-20(4-6-22(26)17-32-35)19-3-5-21(25(29)14-19)13-23(16-30)33-28(36)27-18-31-9-2-12-37-27/h3-6,14-15,17,23-24,27,31H,2,7-13,18H2,1H3,(H,33,36)/t23-,27+/m1/s1 FFSYCNUBRGQIJB-KCWPFWIISA-N 674395 US20240150335, Compound 24 Dipeptidyl peptidase 1 Homo sapiens 1.000 US Patent 10.7270/Q2X06CCR US20240150335 WU, L; ZHAO, L; CHEN, D; YAN, X; CHEN, S Medshine Discovery http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=674395 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=674395&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171466647 497643745 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1411711 Cn1ncc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H25N5O2/c1-28-21-12-18(7-8-19(21)14-26-28)17-5-3-16(4-6-17)11-20(13-24)27-23(29)22-15-25-9-2-10-30-22/h3-8,12,14,20,22,25H,2,9-11,15H2,1H3,(H,27,29)/t20-,22-/m0/s1 MZHADPYRPLGVDH-UNMCSNQZSA-N 674376 US20240150335, Compound 2 Dipeptidyl peptidase 1 Homo sapiens 8.95 US Patent 10.7270/Q2X06CCR US20240150335 WU, L; ZHAO, L; CHEN, D; YAN, X; CHEN, S Medshine Discovery http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=674376 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=674376&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171466630 497643726 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1411712 Cn1nnc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C22H24N6O2/c1-28-20-12-17(7-8-19(20)26-27-28)16-5-3-15(4-6-16)11-18(13-23)25-22(29)21-14-24-9-2-10-30-21/h3-8,12,18,21,24H,2,9-11,14H2,1H3,(H,25,29)/t18-,21-/m0/s1 HNIKVEISKRIEER-RXVVDRJESA-N 674377 US20240150335, Compound 4 Dipeptidyl peptidase 1 Homo sapiens 1.32 US Patent 10.7270/Q2X06CCR US20240150335 WU, L; ZHAO, L; CHEN, D; YAN, X; CHEN, S Medshine Discovery http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=674377 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=674377&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171466687 497643727 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1411713 CN1Cc2cc(ccc2C1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C24H26N4O3/c1-28-15-19-12-18(7-8-21(19)24(28)30)17-5-3-16(4-6-17)11-20(13-25)27-23(29)22-14-26-9-2-10-31-22/h3-8,12,20,22,26H,2,9-11,14-15H2,1H3,(H,27,29)/t20-,22-/m0/s1 VUAUEPHRGUBJAZ-UNMCSNQZSA-N 674378 US20240150335, Compound 5 Dipeptidyl peptidase 1 Homo sapiens 9.32 US Patent 10.7270/Q2X06CCR US20240150335 WU, L; ZHAO, L; CHEN, D; YAN, X; CHEN, S Medshine Discovery http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=674378 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=674378&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171466609 497643728 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1411714 Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)c(F)c1 InChI=1S/C23H23FN4O4/c1-28-19-11-15(5-6-20(19)32-23(28)30)14-3-4-16(18(24)10-14)9-17(12-25)27-22(29)21-13-26-7-2-8-31-21/h3-6,10-11,17,21,26H,2,7-9,13H2,1H3,(H,27,29)/t17-,21-/m0/s1 ONJDRXNRBKHINH-UWJYYQICSA-N 633575 (S) N ((S)-1-cyano-2-(2-fluoro-4-(3-methyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)phenyl)ethyl)-1,4-oxazepane-2-carboxamide ::US11807635, Compound 1::US20240150335, Compound 6 Dipeptidyl peptidase 1 Homo sapiens 0.640 US Patent 10.7270/Q2X06CCR US20240150335 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=633575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=633575&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 162738687 486499289 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1411715 Cn1nnc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)c(F)c1 InChI=1S/C22H23FN6O2/c1-29-20-11-15(5-6-19(20)27-28-29)14-3-4-16(18(23)10-14)9-17(12-24)26-22(30)21-13-25-7-2-8-31-21/h3-6,10-11,17,21,25H,2,7-9,13H2,1H3,(H,26,30)/t17-,21-/m0/s1 LWCXISFRDQHNRG-UWJYYQICSA-N 674380 US20240150335, Compound 7 Dipeptidyl peptidase 1 Homo sapiens 2.49 US Patent 10.7270/Q2X06CCR US20240150335 WU, L; ZHAO, L; CHEN, D; YAN, X; CHEN, S Medshine Discovery http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=674380 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=674380&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171466596 497643730 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1411716 Cn1ncc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)c(F)c1 InChI=1S/C23H24FN5O2/c1-29-21-11-16(4-6-18(21)13-27-29)15-3-5-17(20(24)10-15)9-19(12-25)28-23(30)22-14-26-7-2-8-31-22/h3-6,10-11,13,19,22,26H,2,7-9,14H2,1H3,(H,28,30)/t19-,22-/m0/s1 IVFUIEQQJAEOCC-UGKGYDQZSA-N 674381 US20240150335, Compound 8 Dipeptidyl peptidase 1 Homo sapiens 2.40 US Patent 10.7270/Q2X06CCR US20240150335 WU, L; ZHAO, L; CHEN, D; YAN, X; CHEN, S Medshine Discovery http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=674381 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=674381&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171466655 497643731 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1411717 CC(C)n1ncc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)c(F)c1 InChI=1S/C25H28FN5O2/c1-16(2)31-23-12-18(5-7-20(23)14-29-31)17-4-6-19(22(26)11-17)10-21(13-27)30-25(32)24-15-28-8-3-9-33-24/h4-7,11-12,14,16,21,24,28H,3,8-10,15H2,1-2H3,(H,30,32)/t21-,24-/m0/s1 ZZPRBWGGFQRCSH-URXFXBBRSA-N 674383 US20240150335, Compound 10 Dipeptidyl peptidase 1 Homo sapiens 8.53 US Patent 10.7270/Q2X06CCR US20240150335 WU, L; ZHAO, L; CHEN, D; YAN, X; CHEN, S Medshine Discovery http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=674383 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=674383&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171466612 497643733 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1411718 Fc1cc(ccc1C[C@H](NC(=O)[C@@H]1CNCCCO1)C#N)-c1ccc2cnn(C3CCOCC3)c2c1 InChI=1S/C27H30FN5O3/c28-24-13-18(19-3-5-21-16-31-33(25(21)14-19)23-6-10-35-11-7-23)2-4-20(24)12-22(15-29)32-27(34)26-17-30-8-1-9-36-26/h2-5,13-14,16,22-23,26,30H,1,6-12,17H2,(H,32,34)/t22-,26-/m0/s1 DBKAJGGNUTXWPE-NVQXNPDNSA-N 674384 US20240150335, Compound 12 Dipeptidyl peptidase 1 Homo sapiens 1.81 US Patent 10.7270/Q2X06CCR US20240150335 WU, L; ZHAO, L; CHEN, D; YAN, X; CHEN, S Medshine Discovery http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=674384 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=674384&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171466603 497643734 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1411719 Fc1cc(ccc1C[C@H](NC(=O)[C@@H]1CNCCCO1)C#N)-c1ccc2nccn2c1 InChI=1S/C22H22FN5O2/c23-19-11-15(17-4-5-21-26-7-8-28(21)14-17)2-3-16(19)10-18(12-24)27-22(29)20-13-25-6-1-9-30-20/h2-5,7-8,11,14,18,20,25H,1,6,9-10,13H2,(H,27,29)/t18-,20-/m0/s1 HTAFAXQYBAZYKM-ICSRJNTNSA-N 674385 US20240150335, Compound 13 Dipeptidyl peptidase 1 Homo sapiens 6.33 US Patent 10.7270/Q2X06CCR US20240150335 WU, L; ZHAO, L; CHEN, D; YAN, X; CHEN, S Medshine Discovery http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=674385 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=674385&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171466616 497643735 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1411720 Fc1cc(ccc1C[C@@H](NC(=O)[C@@H]1CNCCCO1)C#N)-c1ccc2nccn2c1 InChI=1S/C22H22FN5O2/c23-19-11-15(17-4-5-21-26-7-8-28(21)14-17)2-3-16(19)10-18(12-24)27-22(29)20-13-25-6-1-9-30-20/h2-5,7-8,11,14,18,20,25H,1,6,9-10,13H2,(H,27,29)/t18-,20+/m1/s1 HTAFAXQYBAZYKM-QUCCMNQESA-N 674386 US20240150335, Compound 14 Dipeptidyl peptidase 1 Homo sapiens 2.79 US Patent 10.7270/Q2X06CCR US20240150335 WU, L; ZHAO, L; CHEN, D; YAN, X; CHEN, S Medshine Discovery http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=674386 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=674386&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171466634 497643736 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1411721 Cn1nc(F)c2ccc(cc12)-c1ccc(C[C@@H](NC(=O)[C@@H]2CNCCCO2)C#N)c(F)c1 InChI=1S/C23H23F2N5O2/c1-30-20-11-15(5-6-18(20)22(25)29-30)14-3-4-16(19(24)10-14)9-17(12-26)28-23(31)21-13-27-7-2-8-32-21/h3-6,10-11,17,21,27H,2,7-9,13H2,1H3,(H,28,31)/t17-,21+/m1/s1 IETHEQXTUYHTEC-UTKZUKDTSA-N 674390 US20240150335, Compound 18 Dipeptidyl peptidase 1 Homo sapiens 5.43 US Patent 10.7270/Q2X06CCR US20240150335 WU, L; ZHAO, L; CHEN, D; YAN, X; CHEN, S Medshine Discovery http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=674390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=674390&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171466659 497643740 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1411722 Fc1cc(ccc1C[C@@H](NC(=O)[C@@H]1CNCCCO1)C#N)-c1cc(F)c2cn[nH]c2c1 674391 US20240150335, Compound 19 Dipeptidyl peptidase 1 Homo sapiens 8.70 US Patent 10.7270/Q2X06CCR US20240150335 WU, L; ZHAO, L; CHEN, D; YAN, X; CHEN, S Medshine Discovery http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=674391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=674391&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171918772 497643741 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1411723 Cn1ncc2ncc(cc12)-c1ccc(C[C@@H](NC(=O)[C@@H]2CNCCCO2)C#N)c(F)c1 InChI=1S/C22H23FN6O2/c1-29-20-9-16(11-26-19(20)12-27-29)14-3-4-15(18(23)8-14)7-17(10-24)28-22(30)21-13-25-5-2-6-31-21/h3-4,8-9,11-12,17,21,25H,2,5-7,13H2,1H3,(H,28,30)/t17-,21+/m1/s1 MTCCJVYRRFEOLX-UTKZUKDTSA-N 674392 US20240150335, Compound 20 Dipeptidyl peptidase 1 Homo sapiens 9.58 US Patent 10.7270/Q2X06CCR US20240150335 WU, L; ZHAO, L; CHEN, D; YAN, X; CHEN, S Medshine Discovery http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=674392 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=674392&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171918773 497643742 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1411724 Fc1cc(ccc1C[C@@H](NC(=O)[C@@H]1CNCCCO1)C#N)-c1cnc2cc[nH]c2c1 674393 US20240150335, Compound 21 Dipeptidyl peptidase 1 Homo sapiens 9.27 US Patent 10.7270/Q2X06CCR US20240150335 WU, L; ZHAO, L; CHEN, D; YAN, X; CHEN, S Medshine Discovery http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=674393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=674393&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171918774 497643743 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1411725 CN1CCC(CC1)n1ncc2ccc(cc12)-c1ccc(C[C@@H](NC(=O)[C@@H]2CNCCCO2)C#N)c(F)c1 InChI=1S/C28H33FN6O2/c1-34-10-7-24(8-11-34)35-26-15-20(4-6-22(26)17-32-35)19-3-5-21(25(29)14-19)13-23(16-30)33-28(36)27-18-31-9-2-12-37-27/h3-6,14-15,17,23-24,27,31H,2,7-13,18H2,1H3,(H,33,36)/t23-,27+/m1/s1 FFSYCNUBRGQIJB-KCWPFWIISA-N 674395 US20240150335, Compound 24 Dipeptidyl peptidase 1 Homo sapiens 3.12 US Patent 10.7270/Q2X06CCR US20240150335 WU, L; ZHAO, L; CHEN, D; YAN, X; CHEN, S Medshine Discovery http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=674395 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=674395&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 171466647 497643745 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5 Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1387462 NC1(CCOCC1)C(=O)N[C@@H](Cc1ccc2C(=O)N(Cc2c1)c1ccccc1)C#N InChI=1S/C23H24N4O3/c24-14-18(26-22(29)23(25)8-10-30-11-9-23)13-16-6-7-20-17(12-16)15-27(21(20)28)19-4-2-1-3-5-19/h1-7,12,18H,8-11,13,15,25H2,(H,26,29)/t18-/m0/s1 RYMALUXCDQFRSL-SFHVURJKSA-N 657936 (S)-4-Amino-N-(1-cyano-2-(1-oxo-2-phenylisoindolin-5-yl)ethyl)tetrahydro-2H-pyran-4-carboxamide::US20240083888, Compound 1 Dipeptidyl peptidase 1 42.0 US Patent 10.7270/Q22F7SQ9 US20240083888 Hao, X; Gong, S; Shen, D; Du, X Reistone Biopharma Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=657936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=657936&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1387463 O=C(N[C@@H](Cc1ccc2C(=O)N(Cc2c1)c1ccccc1)C#N)[C@@H]1CNCCCO1 InChI=1S/C23H24N4O3/c24-13-18(26-22(28)21-14-25-9-4-10-30-21)12-16-7-8-20-17(11-16)15-27(23(20)29)19-5-2-1-3-6-19/h1-3,5-8,11,18,21,25H,4,9-10,12,14-15H2,(H,26,28)/t18-,21-/m0/s1 DFDKMKRJZGIVSW-RXVVDRJESA-N 657937 (S)-N-((S)-1-Cyano-2-(1-oxo-2-phenylisoindolin-5-yl)ethyl)-1,4-oxazepane-2-carboxamide::US20240083888, Compound 2 Dipeptidyl peptidase 1 710 US Patent 10.7270/Q22F7SQ9 US20240083888 Hao, X; Gong, S; Shen, D; Du, X Reistone Biopharma Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=657937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=657937&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1387464 O=C(NC(Cc1ccc2CCCCc2c1)C#N)[C@@H]1CNCCCO1 InChI=1S/C19H25N3O2/c20-12-17(22-19(23)18-13-21-8-3-9-24-18)11-14-6-7-15-4-1-2-5-16(15)10-14/h6-7,10,17-18,21H,1-5,8-9,11,13H2,(H,22,23)/t17?,18-/m0/s1 CCRGRTAYZMMCQG-ZVAWYAOSSA-N 657938 (2S)-N-(1-Cyano-2-(5,6,7,8-tetrahydronaphthalen-2-yl)ethyl)-1,4-oxazepane-2-carboxamide trifluoroacetate::US20240083888, Compound 3 Dipeptidyl peptidase 1 4254 US Patent 10.7270/Q22F7SQ9 US20240083888 Hao, X; Gong, S; Shen, D; Du, X Reistone Biopharma Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=657938 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=657938&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1387465 NC1(CCOCC1)C(=O)NC(Cc1ccc2CCCCc2c1)C#N InChI=1S/C19H25N3O2/c20-13-17(22-18(23)19(21)7-9-24-10-8-19)12-14-5-6-15-3-1-2-4-16(15)11-14/h5-6,11,17H,1-4,7-10,12,21H2,(H,22,23) JCZDYOKHAGDVQM-UHFFFAOYSA-N 657939 4-Amino-N-(1-cyano-2-(5,6,7,8-tetrahydronaphthalen-2-yl)ethyl)tetrahydro-2H-pyran-4-carboxamide::US20240083888, Compound 4 Dipeptidyl peptidase 1 54.0 US Patent 10.7270/Q22F7SQ9 US20240083888 Hao, X; Gong, S; Shen, D; Du, X Reistone Biopharma Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=657939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=657939&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1387466 O=C(NC(Cc1ccc2CCCc2c1)C#N)[C@@H]1CNCCCO1 InChI=1S/C18H23N3O2/c19-11-16(21-18(22)17-12-20-7-2-8-23-17)10-13-5-6-14-3-1-4-15(14)9-13/h5-6,9,16-17,20H,1-4,7-8,10,12H2,(H,21,22)/t16?,17-/m0/s1 NDCHSULFGPPINN-DJNXLDHESA-N 657940 (2S)-N-(1-Cyano-2-(2,3-dihydro-1H-inden-5-yl)ethyl)-1,4-oxazepane-2-carboxamide trifluoroacetate::US20240083888, Compound 5 Dipeptidyl peptidase 1 3586 US Patent 10.7270/Q22F7SQ9 US20240083888 Hao, X; Gong, S; Shen, D; Du, X Reistone Biopharma Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=657940 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=657940&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1387467 NC1(CCOCC1)C(=O)NC(Cc1ccc2CCCc2c1)C#N InChI=1S/C18H23N3O2/c19-12-16(21-17(22)18(20)6-8-23-9-7-18)11-13-4-5-14-2-1-3-15(14)10-13/h4-5,10,16H,1-3,6-9,11,20H2,(H,21,22) YMNXHZVPLHGNHA-UHFFFAOYSA-N 657941 4-Amino-N-(1-cyano-2-(2,3-dihydro-1H-inden-5-yl)ethyl)tetrahydro-2H-pyran-4-carboxamide::US20240083888, Compound 6 Dipeptidyl peptidase 1 56.0 US Patent 10.7270/Q22F7SQ9 US20240083888 Hao, X; Gong, S; Shen, D; Du, X Reistone Biopharma Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=657941 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=657941&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1387468 NC1(CCOCC1)C(=O)NC(Cc1ccc-2c(CCc3ccccc-23)c1)C#N InChI=1S/C23H25N3O2/c24-15-19(26-22(27)23(25)9-11-28-12-10-23)14-16-5-8-21-18(13-16)7-6-17-3-1-2-4-20(17)21/h1-5,8,13,19H,6-7,9-12,14,25H2,(H,26,27) SALRSUVWXLAPNT-UHFFFAOYSA-N 657942 4-Amino-N-(1-cyano-2-(9,10-dihydrophenanthren-2-yl)ethyl)tetrahydro-2H-pyran-4-carboxamide::US20240083888, Compound 7 Dipeptidyl peptidase 1 6.80 US Patent 10.7270/Q22F7SQ9 US20240083888 Hao, X; Gong, S; Shen, D; Du, X Reistone Biopharma Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=657942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=657942&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1387469 O=C(N[C@@H](Cc1ccc-2c(CCc3ccccc-23)c1)C#N)[C@@H]1CNCCCO1 InChI=1S/C23H25N3O2/c24-14-19(26-23(27)22-15-25-10-3-11-28-22)13-16-6-9-21-18(12-16)8-7-17-4-1-2-5-20(17)21/h1-2,4-6,9,12,19,22,25H,3,7-8,10-11,13,15H2,(H,26,27)/t19-,22-/m0/s1 IIRKOPZHZBEVTD-UGKGYDQZSA-N 657943 (S)-N-((S)-1-Cyano-2-(9,10-dihydrophenanthren-2-yl)ethyl)-1,4-oxazepane-2-carboxamide::US20240083888, Compound 8 Dipeptidyl peptidase 1 60.0 US Patent 10.7270/Q22F7SQ9 US20240083888 Hao, X; Gong, S; Shen, D; Du, X Reistone Biopharma Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=657943 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=657943&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1387470 CN1CCc2cc(C[C@H](NC(=O)[C@@H]3CNCCCO3)C#N)ccc2C1 InChI=1S/C19H26N4O2/c1-23-7-5-15-9-14(3-4-16(15)13-23)10-17(11-20)22-19(24)18-12-21-6-2-8-25-18/h3-4,9,17-18,21H,2,5-8,10,12-13H2,1H3,(H,22,24)/t17-,18-/m0/s1 MAFMMHIMRJICNJ-ROUUACIJSA-N 657944 (S)-N-((S)-1-Cyano-2-(2-methyl-1,2,3,4-tetrahydroisoquinolin-6-yl)ethyl)-1,4-oxazepane-2-carboxamide::US20240083888, Compound 9 Dipeptidyl peptidase 1 1744 US Patent 10.7270/Q22F7SQ9 US20240083888 Hao, X; Gong, S; Shen, D; Du, X Reistone Biopharma Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=657944 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=657944&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1387471 NC1(CCOCC1)C(=O)N[C@@H](Cc1ccc2CCCOc2c1)C#N InChI=1S/C18H23N3O3/c19-12-15(21-17(22)18(20)5-8-23-9-6-18)10-13-3-4-14-2-1-7-24-16(14)11-13/h3-4,11,15H,1-2,5-10,20H2,(H,21,22)/t15-/m0/s1 FOKVWUSWRAHVOL-HNNXBMFYSA-N 657945 (S)-4-Amino-N-(2-(chroman-7-yl)-1-cyanoethyl)tetrahydro-2H-pyran-4-carboxamide::US20240083888, Compound 10 Dipeptidyl peptidase 1 74.0 US Patent 10.7270/Q22F7SQ9 US20240083888 Hao, X; Gong, S; Shen, D; Du, X Reistone Biopharma Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=657945 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=657945&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1387472 Fc1ccc-2c(COc3cc(CC(NC(=O)[C@@H]4CNCCCO4)C#N)ccc-23)c1 InChI=1S/C22H22FN3O3/c23-16-3-5-18-15(10-16)13-29-20-9-14(2-4-19(18)20)8-17(11-24)26-22(27)21-12-25-6-1-7-28-21/h2-5,9-10,17,21,25H,1,6-8,12-13H2,(H,26,27)/t17?,21-/m0/s1 OSYKUFRVDHUCCL-LFABVHOISA-N 657946 (2S)—N-(1-Cyano-2-(8-fluoro-6H-benzo[c]chromen-3-yl)ethyl)-1,4-oxazepane-2-carboxamide formate::US20240083888, Compound 11 Dipeptidyl peptidase 1 74.0 US Patent 10.7270/Q22F7SQ9 US20240083888 Hao, X; Gong, S; Shen, D; Du, X Reistone Biopharma Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=657946 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=657946&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1387473 Fc1ccc-2c(COc3cc(CC(NC(=O)[C@@H]4CNCCCO4)C#N)c(F)cc-23)c1 InChI=1S/C22H21F2N3O3/c23-15-2-3-17-14(6-15)12-30-20-8-13(19(24)9-18(17)20)7-16(10-25)27-22(28)21-11-26-4-1-5-29-21/h2-3,6,8-9,16,21,26H,1,4-5,7,11-12H2,(H,27,28)/t16?,21-/m0/s1 DDFAMIXTNGJAMT-MRNPHLECSA-N 657947 (2S)-N-(1-Cyano-2-(2,8-difluoro-6H-benzo[c]chromen-3-yl)ethyl)-1,4-oxazepane-2-carboxamide::US20240083888, Compound 12 Dipeptidyl peptidase 1 16.0 US Patent 10.7270/Q22F7SQ9 US20240083888 Hao, X; Gong, S; Shen, D; Du, X Reistone Biopharma Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=657947 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=657947&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1387474 O=C(NC(Cc1ccc-2c(OCc3cc(ccc-23)C#N)c1)C#N)[C@@H]1CNCCCO1 InChI=1S/C23H22N4O3/c24-11-16-3-4-19-17(8-16)14-30-21-10-15(2-5-20(19)21)9-18(12-25)27-23(28)22-13-26-6-1-7-29-22/h2-5,8,10,18,22,26H,1,6-7,9,13-14H2,(H,27,28)/t18?,22-/m0/s1 SYASBQIKXGLGMY-YSYXNDDBSA-N 657948 (2S)-N-(1-Cyano-2-(8-cyano-6H-benzo[c]chromen-3-yl)ethyl)-1,4-oxazepane-2-carboxamide::US20240083888, Compound 13 Dipeptidyl peptidase 1 37.0 US Patent 10.7270/Q22F7SQ9 US20240083888 Hao, X; Gong, S; Shen, D; Du, X Reistone Biopharma Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=657948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=657948&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1387475 Fc1cc-2c(OCc3cc(ccc-23)C#N)cc1C[C@H](NC(=O)[C@@H]1CNCCCO1)C#N InChI=1S/C23H21FN4O3/c24-20-9-19-18-3-2-14(10-25)6-16(18)13-31-21(19)8-15(20)7-17(11-26)28-23(29)22-12-27-4-1-5-30-22/h2-3,6,8-9,17,22,27H,1,4-5,7,12-13H2,(H,28,29)/t17-,22-/m0/s1 AEHYRYFFWZDTDE-JTSKRJEESA-N 657949 (S)-N-((S)-1-Cyano-2-(8-cyano-2-fluoro-6H-benzo[c]chromen-3-yl)ethyl)-1,4-oxazepane-2-carboxamide::US20240083888, Compound 14 Dipeptidyl peptidase 1 5.31 US Patent 10.7270/Q22F7SQ9 US20240083888 Hao, X; Gong, S; Shen, D; Du, X Reistone Biopharma Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=657949 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=657949&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1387476 Fc1ccc-2c(OCc3cc(CC(NC(=O)[C@@H]4CNCCCO4)C#N)ccc-23)c1 InChI=1S/C22H22FN3O3/c23-16-3-5-19-18-4-2-14(8-15(18)13-29-20(19)10-16)9-17(11-24)26-22(27)21-12-25-6-1-7-28-21/h2-5,8,10,17,21,25H,1,6-7,9,12-13H2,(H,26,27)/t17?,21-/m0/s1 TXCSXGJJLBOOAD-LFABVHOISA-N 657950 (2S)-N-(1-Cyano-2-(3-fluoro-6H-benzo[c]chromen-8-yl)ethyl)-1,4-oxazepane-2-carboxamide::US20240083888, Compound 15 Dipeptidyl peptidase 1 304 US Patent 10.7270/Q22F7SQ9 US20240083888 Hao, X; Gong, S; Shen, D; Du, X Reistone Biopharma Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=657950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=657950&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1387477 Fc1cc2COc3cc(C[C@H](NC(=O)[C@@H]4CNCCCO4)C#N)ccc3-c2cc1F InChI=1S/C22H21F2N3O3/c23-18-8-14-12-30-20-7-13(2-3-16(20)17(14)9-19(18)24)6-15(10-25)27-22(28)21-11-26-4-1-5-29-21/h2-3,7-9,15,21,26H,1,4-6,11-12H2,(H,27,28)/t15-,21-/m0/s1 KRIBYUGJXZIDAM-BTYIYWSLSA-N 657951 (S)-N-((S)-1-Cyano-2-(8,9-difluoro-6H-benzo[c]chromen-3-yl)ethyl)-1,4-oxazepane-2-carboxamide::US20240083888, Compound 16 Dipeptidyl peptidase 1 91.0 US Patent 10.7270/Q22F7SQ9 US20240083888 Hao, X; Gong, S; Shen, D; Du, X Reistone Biopharma Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=657951 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=657951&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1387478 NC1(CCOCC1)C(=O)N[C@@H](Cc1ccc-2c(OCc3cc(F)c(F)cc-23)c1)C#N InChI=1S/C22H21F2N3O3/c23-18-9-14-12-30-20-8-13(1-2-16(20)17(14)10-19(18)24)7-15(11-25)27-21(28)22(26)3-5-29-6-4-22/h1-2,8-10,15H,3-7,12,26H2,(H,27,28)/t15-/m0/s1 KCHXEGIFBKYRSV-HNNXBMFYSA-N 657952 (S)-4-Amino-N-(1-cyano-2-(8,9-difluoro-6H-benzo[c]chromen-3-yl)ethyl)tetrahydro-2H-pyran-4-carboxamide::US20240083888, Compound 17 Dipeptidyl peptidase 1 5.70 US Patent 10.7270/Q22F7SQ9 US20240083888 Hao, X; Gong, S; Shen, D; Du, X Reistone Biopharma Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=657952 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=657952&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1387479 Fc1cc-2c(OCc3cc(ncc-23)C#N)cc1CC(NC(=O)[C@@H]1CNCCCO1)C#N InChI=1S/C22H20FN5O3/c23-19-7-17-18-10-27-15(8-24)5-14(18)12-31-20(17)6-13(19)4-16(9-25)28-22(29)21-11-26-2-1-3-30-21/h5-7,10,16,21,26H,1-4,11-12H2,(H,28,29)/t16?,21-/m0/s1 FYLLEQLFFOIKHC-MRNPHLECSA-N 657953 (2S)-N-(1-Cyano-2-(3-cyano-9-fluoro-5H-chromeno[4,3-c]pyridin-8-yl)ethyl)-1,4-oxazepane-2-carboxamide::US20240083888, Compound 18::US20240083888, Compound 19 Dipeptidyl peptidase 1 49.0 US Patent 10.7270/Q22F7SQ9 US20240083888 Hao, X; Gong, S; Shen, D; Du, X Reistone Biopharma Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=657953 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=657953&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1387480 Fc1cc-2c(OCc3cc(ncc-23)C#N)cc1CC(NC(=O)[C@@H]1CNCCCO1)C#N InChI=1S/C22H20FN5O3/c23-19-7-17-18-10-27-15(8-24)5-14(18)12-31-20(17)6-13(19)4-16(9-25)28-22(29)21-11-26-2-1-3-30-21/h5-7,10,16,21,26H,1-4,11-12H2,(H,28,29)/t16?,21-/m0/s1 FYLLEQLFFOIKHC-MRNPHLECSA-N 657953 (2S)-N-(1-Cyano-2-(3-cyano-9-fluoro-5H-chromeno[4,3-c]pyridin-8-yl)ethyl)-1,4-oxazepane-2-carboxamide::US20240083888, Compound 18::US20240083888, Compound 19 Dipeptidyl peptidase 1 32.0 US Patent 10.7270/Q22F7SQ9 US20240083888 Hao, X; Gong, S; Shen, D; Du, X Reistone Biopharma Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=657953 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=657953&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1387481 Fc1ccc-2c(COc3cc(C[C@H](NC(=O)[C@@H]4CNCCCO4)C#N)c(F)cc-23)c1 InChI=1S/C22H21F2N3O3/c23-15-2-3-17-14(6-15)12-30-20-8-13(19(24)9-18(17)20)7-16(10-25)27-22(28)21-11-26-4-1-5-29-21/h2-3,6,8-9,16,21,26H,1,4-5,7,11-12H2,(H,27,28)/t16-,21-/m0/s1 DDFAMIXTNGJAMT-KKSFZXQISA-N 657955 (S)-N-((S)-1-Cyano-2-(2,8-difluoro-6H-benzo[c]chromen-3-yl)ethyl)-1,4-oxazepane-2-carboxamide::US20240083888, Compound 20 Dipeptidyl peptidase 1 11.0 US Patent 10.7270/Q22F7SQ9 US20240083888 Hao, X; Gong, S; Shen, D; Du, X Reistone Biopharma Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=657955 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=657955&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1387482 NC1(CCOCC1)C(=O)NC(Cc1ccc-2c(OCc3cc(F)ccc-23)c1)C#N InChI=1S/C22H22FN3O3/c23-16-2-4-18-15(11-16)13-29-20-10-14(1-3-19(18)20)9-17(12-24)26-21(27)22(25)5-7-28-8-6-22/h1-4,10-11,17H,5-9,13,25H2,(H,26,27) VZGJPSRZNOYQEH-UHFFFAOYSA-N 657956 4-Amino-N-(1-cyano-2-(8-fluoro-6H-benzo[c]chromen-3-yl)ethyl)tetrahydro-2H-pyran-4-carboxamide formate::US20240083888, Compound 22::US20240083888, Compound 23 Dipeptidyl peptidase 1 3.20 US Patent 10.7270/Q22F7SQ9 US20240083888 Hao, X; Gong, S; Shen, D; Du, X Reistone Biopharma Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=657956 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=657956&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1387483 NC1(CCOCC1)C(=O)NC(Cc1ccc-2c(OCc3cc(F)ccc-23)c1)C#N InChI=1S/C22H22FN3O3/c23-16-2-4-18-15(11-16)13-29-20-10-14(1-3-19(18)20)9-17(12-24)26-21(27)22(25)5-7-28-8-6-22/h1-4,10-11,17H,5-9,13,25H2,(H,26,27) VZGJPSRZNOYQEH-UHFFFAOYSA-N 657956 4-Amino-N-(1-cyano-2-(8-fluoro-6H-benzo[c]chromen-3-yl)ethyl)tetrahydro-2H-pyran-4-carboxamide formate::US20240083888, Compound 22::US20240083888, Compound 23 Dipeptidyl peptidase 1 14.5 US Patent 10.7270/Q22F7SQ9 US20240083888 Hao, X; Gong, S; Shen, D; Du, X Reistone Biopharma Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=657956 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=657956&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1387484 NC1(CCOCC1)C(=O)NC(Cc1cc2OCc3cc(F)ccc3-c2cc1F)C#N InChI=1S/C22H21F2N3O3/c23-15-1-2-17-14(7-15)12-30-20-9-13(19(24)10-18(17)20)8-16(11-25)27-21(28)22(26)3-5-29-6-4-22/h1-2,7,9-10,16H,3-6,8,12,26H2,(H,27,28) QGDLODRFGGIDHC-UHFFFAOYSA-N 657958 4-Amino-N-(1-cyano-2-(2,8-difluoro-6H-benzo[c]chromen-3-yl)ethyl)tetrahydro-2H-pyran-4-carboxamide::US20240083888, Compound 24 Dipeptidyl peptidase 1 2.70 US Patent 10.7270/Q22F7SQ9 US20240083888 Hao, X; Gong, S; Shen, D; Du, X Reistone Biopharma Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=657958 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=657958&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1387485 NC1(CCOCC1)C(=O)NC(Cc1ccc-2c(OCc3cc(ccc-23)C#N)c1)C#N InChI=1S/C23H22N4O3/c24-12-16-2-3-19-17(9-16)14-30-21-11-15(1-4-20(19)21)10-18(13-25)27-22(28)23(26)5-7-29-8-6-23/h1-4,9,11,18H,5-8,10,14,26H2,(H,27,28) HNVLWIMSQCICSF-UHFFFAOYSA-N 657960 4-Amino-N-(1-cyano-2-(8-cyano-6H-benzo[c]chromen-3-yl)ethyl)tetrahydro-2H-pyran-4-carboxamide::US20240083888, Compound 25 Dipeptidyl peptidase 1 3.10 US Patent 10.7270/Q22F7SQ9 US20240083888 Hao, X; Gong, S; Shen, D; Du, X Reistone Biopharma Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=657960 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=657960&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1387486 Fc1cc-2c(OCc3cc(ccc-23)C#N)cc1C[C@H](NC(=O)[C@@H]1C[C@@H]2CCC[C@@H]2N1)C#N InChI=1S/C25H23FN4O2/c26-21-10-20-19-5-4-14(11-27)6-17(19)13-32-24(20)9-16(21)7-18(12-28)29-25(31)23-8-15-2-1-3-22(15)30-23/h4-6,9-10,15,18,22-23,30H,1-3,7-8,13H2,(H,29,31)/t15-,18-,22-,23-/m0/s1 JJUWCCNYJIVNFL-NPCGQVANSA-N 657961 (2S,3aS,6aS)-N-((S)-1-Cyano-2-(8-cyano-2-fluoro-6H-benzo[c]chromen-3-yl)ethyl)octahydrocyclopenta[b]pyrrole-2-carboxamide::US20240083888, Compound 26 Dipeptidyl peptidase 1 8.90 US Patent 10.7270/Q22F7SQ9 US20240083888 Hao, X; Gong, S; Shen, D; Du, X Reistone Biopharma Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=657961 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=657961&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1387487 CC1(C)Oc2cc(C[C@H](NC(=O)[C@@H]3CNCCCO3)C#N)c(F)cc2-c2ccc(cc12)C#N InChI=1S/C25H25FN4O3/c1-25(2)20-8-15(12-27)4-5-18(20)19-11-21(26)16(10-22(19)33-25)9-17(13-28)30-24(31)23-14-29-6-3-7-32-23/h4-5,8,10-11,17,23,29H,3,6-7,9,14H2,1-2H3,(H,30,31)/t17-,23-/m0/s1 PIALKYCMAUMUFO-SBUREZEXSA-N 657962 (S)-N-((S)-1-Cyano-2-(8-cyano-2-fluoro-6,6-dimethyl-6H-benzo[c]chromen-3-yl)ethyl)-1,4-oxazepane-2-carboxamide::US20240083888, Compound 27 Dipeptidyl peptidase 1 23.0 US Patent 10.7270/Q22F7SQ9 US20240083888 Hao, X; Gong, S; Shen, D; Du, X Reistone Biopharma Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=657962 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=657962&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1387488 CS(=O)(=O)c1ccc-2c(COc3cc(CC(NC(=O)[C@@H]4CNCCCO4)C#N)c(F)cc-23)c1 InChI=1S/C23H24FN3O5S/c1-33(29,30)17-3-4-18-15(8-17)13-32-21-9-14(20(24)10-19(18)21)7-16(11-25)27-23(28)22-12-26-5-2-6-31-22/h3-4,8-10,16,22,26H,2,5-7,12-13H2,1H3,(H,27,28)/t16?,22-/m0/s1 SJRIKDIXKCZBMI-XLDIYJRPSA-N 657963 (2S)-N-(1-Cyano-2-(2-fluoro-8-(methylsulfonyl)-6H-benzo[c]chromen-3-yl)ethyl)-1,4-oxazepane-2-carboxamide::US20240083888, Compound 29 Dipeptidyl peptidase 1 17.1 US Patent 10.7270/Q22F7SQ9 US20240083888 Hao, X; Gong, S; Shen, D; Du, X Reistone Biopharma Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=657963 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=657963&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1387489 CS(=O)(=O)c1ccc-2c(COc3cc(C[C@H](NC(=O)[C@@H]4CNCCCO4)C#N)c(F)cc-23)c1 InChI=1S/C23H24FN3O5S/c1-33(29,30)17-3-4-18-15(8-17)13-32-21-9-14(20(24)10-19(18)21)7-16(11-25)27-23(28)22-12-26-5-2-6-31-22/h3-4,8-10,16,22,26H,2,5-7,12-13H2,1H3,(H,27,28)/t16-,22-/m0/s1 SJRIKDIXKCZBMI-AOMKIAJQSA-N 657964 (S)-N-((S)-1-Cyano-2-(2-fluoro-8-(methylsulfonyl)-6H-benzo[c]chromen-3-yl)ethyl)-1,4-oxazepane-2-carboxamide::US20240083888, Compound 30 Dipeptidyl peptidase 1 10.00 US Patent 10.7270/Q22F7SQ9 US20240083888 Hao, X; Gong, S; Shen, D; Du, X Reistone Biopharma Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=657964 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=657964&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1387490 Fc1cc-2c(OCc3ccc(cc-23)C#N)cc1C[C@H](NC(=O)[C@@H]1CNCCCO1)C#N InChI=1S/C23H21FN4O3/c24-20-9-19-18-6-14(10-25)2-3-15(18)13-31-21(19)8-16(20)7-17(11-26)28-23(29)22-12-27-4-1-5-30-22/h2-3,6,8-9,17,22,27H,1,4-5,7,12-13H2,(H,28,29)/t17-,22-/m0/s1 GSRVXSUECAJPSD-JTSKRJEESA-N 657965 (S)-N-((S)-1-Cyano-2-(9-cyano-2-fluoro-6H-benzo[c]chromen-3-yl)ethyl)-1,4-oxazepane-2-carboxamide::US20240083888, Compound 32 Dipeptidyl peptidase 1 13.0 US Patent 10.7270/Q22F7SQ9 US20240083888 Hao, X; Gong, S; Shen, D; Du, X Reistone Biopharma Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=657965 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=657965&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1387491 Fc1cc-2c(OCc3cc(cnc-23)C#N)cc1CC(NC(=O)[C@@H]1CNCCCO1)C#N InChI=1S/C22H20FN5O3/c23-18-7-17-19(31-12-15-4-13(8-24)10-27-21(15)17)6-14(18)5-16(9-25)28-22(29)20-11-26-2-1-3-30-20/h4,6-7,10,16,20,26H,1-3,5,11-12H2,(H,28,29)/t16?,20-/m0/s1 NPBFTZQQZPNTDC-FZCLLLDFSA-N 657966 (2S)—N-(1-Cyano-2-(3-cyano-9-fluoro-5H-chromeno[4,3-b]pyridin-8-yl)ethyl)-1,4-oxazepane-2-carboxamide::US20240083888, Compound 33 Dipeptidyl peptidase 1 85.0 US Patent 10.7270/Q22F7SQ9 US20240083888 Hao, X; Gong, S; Shen, D; Du, X Reistone Biopharma Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=657966 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=657966&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1387492 NC1(CCOCC1)C(=O)NC(Cc1ccc-2c(OCc3ccc(cc-23)C2CCNC2)c1)C#N InChI=1S/C26H30N4O3/c27-14-21(30-25(31)26(28)6-9-32-10-7-26)11-17-1-4-22-23-13-18(19-5-8-29-15-19)2-3-20(23)16-33-24(22)12-17/h1-4,12-13,19,21,29H,5-11,15-16,28H2,(H,30,31) JDCIXNPEGQGIGY-UHFFFAOYSA-N 657967 4-Amino-N-(1-cyano-2-(9-(pyrrolidin-3-yl)-6H-benzo[c]chromen-3-yl)ethyl)tetrahydro-2H-pyran-4-carboxamide::US20240083888, Compound 34 Dipeptidyl peptidase 1 6.20 US Patent 10.7270/Q22F7SQ9 US20240083888 Hao, X; Gong, S; Shen, D; Du, X Reistone Biopharma Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=657967 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=657967&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1387493 Fc1cc-2c(OCc3cc(ccc-23)S(=O)(=O)N2CCC2)cc1CC(NC(=O)[C@@H]1CNCCCO1)C#N InChI=1S/C25H27FN4O5S/c26-22-12-21-20-4-3-19(36(32,33)30-6-2-7-30)10-17(20)15-35-23(21)11-16(22)9-18(13-27)29-25(31)24-14-28-5-1-8-34-24/h3-4,10-12,18,24,28H,1-2,5-9,14-15H2,(H,29,31)/t18?,24-/m0/s1 SZETVIUUGNHECL-LUTIACGYSA-N 657969 (2S)-N-(2-(8-(Azetidin-1-ylsulfonyl)-2-fluoro-6H-benzo[c]chromen-3-yl)-1-cyanoethyl)-1,4-oxazepane-2-carboxamide::US20240083888, Compound 35 Dipeptidyl peptidase 1 15.0 US Patent 10.7270/Q22F7SQ9 US20240083888 Hao, X; Gong, S; Shen, D; Du, X Reistone Biopharma Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=657969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=657969&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1387494 NC1(CCOCC1)C(=O)NC(Cc1ccc-2c(OCCc3cc(F)ccc-23)c1)C#N InChI=1S/C23H24FN3O3/c24-17-2-4-19-16(13-17)5-8-30-21-12-15(1-3-20(19)21)11-18(14-25)27-22(28)23(26)6-9-29-10-7-23/h1-4,12-13,18H,5-11,26H2,(H,27,28) GGHWLJVNXGVPKM-UHFFFAOYSA-N 657970 4-Amino-N-(1-cyano-2-(9-fluoro-6,7-dihydrodibenzo[b,d]oxepin-3-yl)ethyl)tetrahydro-2H-pyran-4-carboxamide::US20240083888, Compound 36 Dipeptidyl peptidase 1 7.10 US Patent 10.7270/Q22F7SQ9 US20240083888 Hao, X; Gong, S; Shen, D; Du, X Reistone Biopharma Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=657970 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=657970&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1387495 NC1(CCOCC1)C(=O)NC(Cc1ccc-2c(COCc3cc(F)ccc-23)c1)C#N InChI=1S/C23H24FN3O3/c24-18-2-4-21-17(11-18)14-30-13-16-9-15(1-3-20(16)21)10-19(12-25)27-22(28)23(26)5-7-29-8-6-23/h1-4,9,11,19H,5-8,10,13-14,26H2,(H,27,28) HHNQCHUZBFVZCP-UHFFFAOYSA-N 657971 4-Amino-N-(1-cyano-2-(9-fluoro-5,7-dihydrodibenzo[c,e]oxepin-3-yl)ethyl)tetrahydro-2H-pyran-4-carboxamide::US20240083888, Compound 37 Dipeptidyl peptidase 1 14.0 US Patent 10.7270/Q22F7SQ9 US20240083888 Hao, X; Gong, S; Shen, D; Du, X Reistone Biopharma Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=657971 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=657971&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1387496 Fc1cc-2c(OCc3cc(F)c(cc-23)C2COC2)cc1C[C@H](NC(=O)[C@@H]1CNCCCO1)C#N InChI=1S/C25H25F2N3O4/c26-21-8-20-18-7-19(16-11-32-12-16)22(27)5-15(18)13-34-23(20)6-14(21)4-17(9-28)30-25(31)24-10-29-2-1-3-33-24/h5-8,16-17,24,29H,1-4,10-13H2,(H,30,31)/t17-,24-/m0/s1 UQXFKPYQOGVGAK-XDHUDOTRSA-N 657972 US20240083888, Compound 38A Dipeptidyl peptidase 1 1.30 US Patent 10.7270/Q22F7SQ9 US20240083888 Hao, X; Gong, S; Shen, D; Du, X Reistone Biopharma Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=657972 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=657972&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1387497 Fc1cc-2c(OCc3cc(F)c(cc-23)C2COC2)cc1C[C@@H](NC(=O)[C@@H]1CNCCCO1)C#N InChI=1S/C25H25F2N3O4/c26-21-8-20-18-7-19(16-11-32-12-16)22(27)5-15(18)13-34-23(20)6-14(21)4-17(9-28)30-25(31)24-10-29-2-1-3-33-24/h5-8,16-17,24,29H,1-4,10-13H2,(H,30,31)/t17-,24+/m1/s1 UQXFKPYQOGVGAK-OSPHWJPCSA-N 657973 US20240083888, Compound 38B Dipeptidyl peptidase 1 76.0 US Patent 10.7270/Q22F7SQ9 US20240083888 Hao, X; Gong, S; Shen, D; Du, X Reistone Biopharma Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=657973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=657973&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1387498 NC1(CCOCC1)C(=O)NC(Cc1ccc-2c(CCOc3cc(F)ccc-23)c1)C#N InChI=1S/C23H24FN3O3/c24-17-2-4-20-19-3-1-15(11-16(19)5-8-30-21(20)13-17)12-18(14-25)27-22(28)23(26)6-9-29-10-7-23/h1-4,11,13,18H,5-10,12,26H2,(H,27,28) BDTLLQSJVHNBHM-UHFFFAOYSA-N 657974 4-Amino-N-(1-cyano-2-(3-fluoro-6,7-dihydrodibenzo[b,d]oxepin-9-yl)ethyl)tetrahydro-2H-pyran-4-carboxamide::US20240083888, Compound 39 Dipeptidyl peptidase 1 46.0 US Patent 10.7270/Q22F7SQ9 US20240083888 Hao, X; Gong, S; Shen, D; Du, X Reistone Biopharma Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=657974 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=657974&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1387499 CN1Cc2cc(F)ccc2-c2ccc(C[C@H](NC(=O)C3(N)CCOCC3)C#N)cc2C1=O InChI=1S/C24H25FN4O3/c1-29-14-16-12-17(25)3-5-19(16)20-4-2-15(11-21(20)22(29)30)10-18(13-26)28-23(31)24(27)6-8-32-9-7-24/h2-5,11-12,18H,6-10,14,27H2,1H3,(H,28,31)/t18-/m0/s1 WNZSSAYWRPVKLK-SFHVURJKSA-N 657975 (S)-4-Amino-N-(1-cyano-2-(9-fluoro-6-methyl-5-oxo-6,7-dihydro-5H-dibenzo[c,e]azepin-3-yl)ethyl)tetrahydro-2H-pyran-4-carboxamide::US20240083888, Compound 40 Dipeptidyl peptidase 1 3.70 US Patent 10.7270/Q22F7SQ9 US20240083888 Hao, X; Gong, S; Shen, D; Du, X Reistone Biopharma Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=657975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=657975&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1387500 CN1Cc2cc(ccc2-c2cc(F)c(C[C@H](NC(=O)[C@@H]3CNCCCO3)C#N)cc2C1=O)C#N InChI=1S/C25H24FN5O3/c1-31-14-17-7-15(11-27)3-4-19(17)20-10-22(26)16(9-21(20)25(31)33)8-18(12-28)30-24(32)23-13-29-5-2-6-34-23/h3-4,7,9-10,18,23,29H,2,5-6,8,13-14H2,1H3,(H,30,32)/t18-,23-/m0/s1 ALYFVKUCOCIHDJ-MBSDFSHPSA-N 657976 (S)-N-((S)-1-Cyano-2-(9-cyano-2-fluoro-6-methyl-5-oxo-6,7-dihydro-5H-dibenzo[c,e]azepin-3-yl)ethyl)-1,4-oxazepane-2-carboxamide::US20240083888, Compound 41 Dipeptidyl peptidase 1 30.5 US Patent 10.7270/Q22F7SQ9 US20240083888 Hao, X; Gong, S; Shen, D; Du, X Reistone Biopharma Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=657976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=657976&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1387501 NC1(CCOCC1)C(=O)N[C@@H](Cc1ccc2c(c1)oc1cc(F)ccc21)C#N InChI=1S/C21H20FN3O3/c22-14-2-4-17-16-3-1-13(10-18(16)28-19(17)11-14)9-15(12-23)25-20(26)21(24)5-7-27-8-6-21/h1-4,10-11,15H,5-9,24H2,(H,25,26)/t15-/m0/s1 FQKDPMWWVJZEQO-HNNXBMFYSA-N 657977 (S)-4-Amino-N-(1-cyano-2-(7-fluorodibenzo[b,d]furan-3-yl)ethyl)tetrahydro-2H-pyran-4-carboxamide::US20240083888, Compound 42 Dipeptidyl peptidase 1 5.70 US Patent 10.7270/Q22F7SQ9 US20240083888 Hao, X; Gong, S; Shen, D; Du, X Reistone Biopharma Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=657977 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=657977&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1387502 CS(=O)(=O)c1ccc2COc3cc(CC(N=C(c4ccccc4)c4ccccc4)C#N)c(F)cc3-c2c1 InChI=1S/C30H23FN2O3S/c1-37(34,35)25-13-12-22-19-36-29-15-23(28(31)17-27(29)26(22)16-25)14-24(18-32)33-30(20-8-4-2-5-9-20)21-10-6-3-7-11-21/h2-13,15-17,24H,14,19H2,1H3 ZBXDSOIBNBFQET-UHFFFAOYSA-N 657978 (2S)-N-(1-Cyano-2-(2-fluoro-9-(methylsulfonyl)-6H-benzo[c]chromen-3-yl)ethyl)-1,4-oxazepane-2-carboxamide::US20240083888, Compound 43 Dipeptidyl peptidase 1 26.0 US Patent 10.7270/Q22F7SQ9 US20240083888 Hao, X; Gong, S; Shen, D; Du, X Reistone Biopharma Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=657978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=657978&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1387503 NC1(CCOCC1)C(=O)N[C@@H](Cc1ccc2c(OCCN(c3ccc(F)cc3)C2=O)c1)C#N InChI=1S/C24H25FN4O4/c25-17-2-4-19(5-3-17)29-9-12-33-21-14-16(1-6-20(21)22(29)30)13-18(15-26)28-23(31)24(27)7-10-32-11-8-24/h1-6,14,18H,7-13,27H2,(H,28,31)/t18-/m0/s1 ATFCSTYKGCMCRX-SFHVURJKSA-N 657979 (S)-4-Amino-N-(1-cyano-2-(4-(4-fluorophenyl)-5-oxo-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepin-8-yl)ethyl)tetrahydro-2H-pyran-4-carboxamide::US20240083888, Compound 44 Dipeptidyl peptidase 1 39.0 US Patent 10.7270/Q22F7SQ9 US20240083888 Hao, X; Gong, S; Shen, D; Du, X Reistone Biopharma Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=657979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=657979&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1387504 NC(=O)[C@H](Cc1ccc2C(=O)N(Cc2c1)c1ccc(cc1)C#N)NC(=O)C1(N)CCOCC1 InChI=1S/C24H25N5O4/c25-13-15-1-4-18(5-2-15)29-14-17-11-16(3-6-19(17)22(29)31)12-20(21(26)30)28-23(32)24(27)7-9-33-10-8-24/h1-6,11,20H,7-10,12,14,27H2,(H2,26,30)(H,28,32)/t20-/m0/s1 NAOOEGRSPJIHDF-FQEVSTJZSA-N 657980 (S)-4-Amino-N-(1-cyano-2-(2-(4-cyanophenyl)-1-oxoisoindolin-5-yl)ethyl)tetrahydro-2H-pyran-4-carboxamide::US20240083888, Compound 45 Dipeptidyl peptidase 1 72.0 US Patent 10.7270/Q22F7SQ9 US20240083888 Hao, X; Gong, S; Shen, D; Du, X Reistone Biopharma Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=657980 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=657980&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1387505 NC(=O)[C@H](Cc1ccc2CN(Cc2c1)C(=O)c1ccc(cc1)C#N)NC(=O)C1(N)CCOCC1 InChI=1S/C25H27N5O4/c26-13-16-1-4-18(5-2-16)23(32)30-14-19-6-3-17(11-20(19)15-30)12-21(22(27)31)29-24(33)25(28)7-9-34-10-8-25/h1-6,11,21H,7-10,12,14-15,28H2,(H2,27,31)(H,29,33)/t21-/m0/s1 DUQMEBZGDOHPAY-NRFANRHFSA-N 657981 (S)-4-Amino-N-(1-cyano-2-(2-(4-cyanobenzoyl)isoindolin-5-yl)ethyl)tetrahydro-2H-pyran-4-carboxamide::US20240083888, Compound 46 Dipeptidyl peptidase 1 54.0 US Patent 10.7270/Q22F7SQ9 US20240083888 Hao, X; Gong, S; Shen, D; Du, X Reistone Biopharma Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=657981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=657981&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1387506 NC(=O)[C@H](Cc1ccc2C(=O)N(Cc2c1)c1cccc(c1)C#N)NC(=O)C1(N)CCOCC1 InChI=1S/C24H25N5O4/c25-13-16-2-1-3-18(11-16)29-14-17-10-15(4-5-19(17)22(29)31)12-20(21(26)30)28-23(32)24(27)6-8-33-9-7-24/h1-5,10-11,20H,6-9,12,14,27H2,(H2,26,30)(H,28,32)/t20-/m0/s1 GWCPTCFXPCJWQT-FQEVSTJZSA-N 657982 (S)-4-Amino-N-(1-cyano-2-(2-(3-cyanophenyl)-1-oxoisoindolin-5-yl)ethyl)tetrahydro-2H-pyran-4-carboxamide formate::US20240083888, Compound 47 Dipeptidyl peptidase 1 29.0 US Patent 10.7270/Q22F7SQ9 US20240083888 Hao, X; Gong, S; Shen, D; Du, X Reistone Biopharma Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=657982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=657982&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1387507 Cn1c2cc(ccc2oc1=O)N1Cc2cc(C[C@H](NC(=O)C3(N)CCOCC3)C(N)=O)ccc2C1=O InChI=1S/C25H27N5O6/c1-29-19-12-16(3-5-20(19)36-24(29)34)30-13-15-10-14(2-4-17(15)22(30)32)11-18(21(26)31)28-23(33)25(27)6-8-35-9-7-25/h2-5,10,12,18H,6-9,11,13,27H2,1H3,(H2,26,31)(H,28,33)/t18-/m0/s1 IUIMRGUDFSBHNX-SFHVURJKSA-N 657983 (S)-4-Amino-N-(1-cyano-2-(2-(3-methyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)-1-oxoisoindolin-5-yl)ethyl)tetrahydro-2H-pyran-4-carboxamide::US20240083888, Compound 48 Dipeptidyl peptidase 1 29.0 US Patent 10.7270/Q22F7SQ9 US20240083888 Hao, X; Gong, S; Shen, D; Du, X Reistone Biopharma Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=657983 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=657983&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1387508 NC(=O)[C@H](Cc1ccc2C(=O)N(CCc2c1)c1ccccc1)NC(=O)C1(N)CCOCC1 InChI=1S/C24H28N4O4/c25-21(29)20(27-23(31)24(26)9-12-32-13-10-24)15-16-6-7-19-17(14-16)8-11-28(22(19)30)18-4-2-1-3-5-18/h1-7,14,20H,8-13,15,26H2,(H2,25,29)(H,27,31)/t20-/m0/s1 JWJGWQJBACKEHK-FQEVSTJZSA-N 657984 (S)-4-Amino-N-(1-cyano-2-(1-oxo-2-phenyl-1,2,3,4-tetrahydroisoquinolin-6-yl)ethyl)tetrahydro-2H-pyran-4-carboxamide::US20240083888, Compound 49 Dipeptidyl peptidase 1 57.0 US Patent 10.7270/Q22F7SQ9 US20240083888 Hao, X; Gong, S; Shen, D; Du, X Reistone Biopharma Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=657984 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=657984&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1387509 NC(=O)[C@H](Cc1ccc2CN(C(=O)c2c1)c1ccccc1)NC(=O)C1(N)CCOCC1 InChI=1S/C23H26N4O4/c24-20(28)19(26-22(30)23(25)8-10-31-11-9-23)13-15-6-7-16-14-27(21(29)18(16)12-15)17-4-2-1-3-5-17/h1-7,12,19H,8-11,13-14,25H2,(H2,24,28)(H,26,30)/t19-/m0/s1 BMSGBLBODHDCFT-IBGZPJMESA-N 657985 (S)-4-Amino-N-(1-cyano-2-(3-oxo-2-phenylisoindolin-5-yl)ethyl)tetrahydro-2H-pyran-4-carboxamide::US20240083888, Compound 50 Dipeptidyl peptidase 1 19.0 US Patent 10.7270/Q22F7SQ9 US20240083888 Hao, X; Gong, S; Shen, D; Du, X Reistone Biopharma Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=657985 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=657985&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1387510 CN1CCc2cc(C[C@H](NC(=O)C3(N)CCOCC3)C#N)ccc2C1 InChI=1S/C19H26N4O2/c1-23-7-4-15-10-14(2-3-16(15)13-23)11-17(12-20)22-18(24)19(21)5-8-25-9-6-19/h2-3,10,17H,4-9,11,13,21H2,1H3,(H,22,24)/t17-/m0/s1 GEDZWTFHOOWVKT-KRWDZBQOSA-N 657986 (S)-4-Amino-N-(1-cyano-2-(2-methyl-1,2,3,4-tetrahydroisoquinolin-6-yl)ethyl)tetrahydro-2H-pyran-4-carboxamide::US20240083888, Compound 51 Dipeptidyl peptidase 1 39.0 US Patent 10.7270/Q22F7SQ9 US20240083888 Hao, X; Gong, S; Shen, D; Du, X Reistone Biopharma Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=657986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=657986&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1387511 NC1(CCOCC1)C(=O)N[C@@H](Cc1ccc2CCOCc2c1)C#N InChI=1S/C18H23N3O3/c19-11-16(21-17(22)18(20)4-7-23-8-5-18)10-13-1-2-14-3-6-24-12-15(14)9-13/h1-2,9,16H,3-8,10,12,20H2,(H,21,22)/t16-/m0/s1 LLATWSPHXXDQJX-INIZCTEOSA-N 657987 (S)-4-Amino-N-(1-cyano-2-(isochroman-7-yl)ethyl)tetrahydro-2H-pyran-4-carboxamide trifluoroacetate::US20240083888, Compound 52 Dipeptidyl peptidase 1 138 US Patent 10.7270/Q22F7SQ9 US20240083888 Hao, X; Gong, S; Shen, D; Du, X Reistone Biopharma Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=657987 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=657987&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1387512 NC1(CCOCC1)C(=O)N[C@@H](Cc1ccc2CN(CCOc2c1)c1ccc(F)cc1)C#N InChI=1S/C24H27FN4O3/c25-19-3-5-21(6-4-19)29-9-12-32-22-14-17(1-2-18(22)16-29)13-20(15-26)28-23(30)24(27)7-10-31-11-8-24/h1-6,14,20H,7-13,16,27H2,(H,28,30)/t20-/m0/s1 XVUCJZJGJXHQRT-FQEVSTJZSA-N 657988 (S)-4-Amino-N-(1-cyano-2-(4-(4-fluorophenyl)-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepin-8-yl)ethyl)tetrahydro-2H-pyran-4-carboxamide::US20240083888, Compound 53 Dipeptidyl peptidase 1 196 US Patent 10.7270/Q22F7SQ9 US20240083888 Hao, X; Gong, S; Shen, D; Du, X Reistone Biopharma Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=657988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=657988&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1387513 NC1(CCOCC1)C(=O)N[C@@H](Cc1ccc2CN(Cc2c1)c1ccc(F)cc1)C#N InChI=1S/C23H25FN4O2/c24-19-3-5-21(6-4-19)28-14-17-2-1-16(11-18(17)15-28)12-20(13-25)27-22(29)23(26)7-9-30-10-8-23/h1-6,11,20H,7-10,12,14-15,26H2,(H,27,29)/t20-/m0/s1 ZLXHZYIOINSHBC-FQEVSTJZSA-N 657989 (S)-4-Amino-N-(1-cyano-2-(2-(4-fluorophenyl)isoindolin-5-yl)ethyl)tetrahydro-2H-pyran-4-carboxamide::US20240083888, Compound 54 Dipeptidyl peptidase 1 28.0 US Patent 10.7270/Q22F7SQ9 US20240083888 Hao, X; Gong, S; Shen, D; Du, X Reistone Biopharma Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=657989 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=657989&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1387514 NC1(CCOCC1)C(=O)N[C@@H](Cc1ccc2CN(Cc2c1)C(=O)c1ccc(F)cc1)C#N InChI=1S/C24H25FN4O3/c25-20-5-3-17(4-6-20)22(30)29-14-18-2-1-16(11-19(18)15-29)12-21(13-26)28-23(31)24(27)7-9-32-10-8-24/h1-6,11,21H,7-10,12,14-15,27H2,(H,28,31)/t21-/m0/s1 CAZZDUXMTCVFQR-NRFANRHFSA-N 657990 (S)-4-Amino-N-(1-cyano-2-(2-(4-fluorobenzoyl)isoindolin-5-yl)ethyl)tetrahydro-2H-pyran-4-carboxamide::US20240083888, Compound 55 Dipeptidyl peptidase 1 174 US Patent 10.7270/Q22F7SQ9 US20240083888 Hao, X; Gong, S; Shen, D; Du, X Reistone Biopharma Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=657990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=657990&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1387515 NC1(CCOCC1)C(=O)N[C@@H](Cc1ccc2CN(CCc2c1)C(=O)c1ccc(F)cc1)C#N InChI=1S/C25H27FN4O3/c26-21-5-3-18(4-6-21)23(31)30-10-7-19-13-17(1-2-20(19)16-30)14-22(15-27)29-24(32)25(28)8-11-33-12-9-25/h1-6,13,22H,7-12,14,16,28H2,(H,29,32)/t22-/m0/s1 UCJFTQIQEMCVGQ-QFIPXVFZSA-N 657991 (S)-4-Amino-N-(1-cyano-2-(2-(4-fluorobenzoyl)-1,2,3,4-tetrahydroisoquinolin-6-yl)eth yl)tetrahydro-2H-pyran-4-carboxamide::US20240083888, Compound 56 Dipeptidyl peptidase 1 37.0 US Patent 10.7270/Q22F7SQ9 US20240083888 Hao, X; Gong, S; Shen, D; Du, X Reistone Biopharma Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=657991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=657991&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1387516 NC1(CCOCC1)C(=O)N[C@@H](Cc1ccc2CN(CCc2c1)c1ccc(F)cc1)C#N InChI=1S/C24H27FN4O2/c25-20-3-5-22(6-4-20)29-10-7-18-13-17(1-2-19(18)16-29)14-21(15-26)28-23(30)24(27)8-11-31-12-9-24/h1-6,13,21H,7-12,14,16,27H2,(H,28,30)/t21-/m0/s1 MZWZXNFFAUCPMB-NRFANRHFSA-N 657992 (S)-4-Amino-N-(1-cyano-2-(2-(4-fluorophenyl)-1,2,3,4-tetrahydroisoquinolin-6-yl)ethyl)tetrahydro-2H-pyran-4-carboxamide::US20240083888, Compound 57 Dipeptidyl peptidase 1 48.0 US Patent 10.7270/Q22F7SQ9 US20240083888 Hao, X; Gong, S; Shen, D; Du, X Reistone Biopharma Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=657992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=657992&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1387517 NC1(CCCCC1)C(=O)N[C@@H](Cc1ccc2CN(C(=O)Cc2c1)c1ccc(F)cc1)C#N InChI=1S/C25H27FN4O2/c26-20-6-8-22(9-7-20)30-16-18-5-4-17(12-19(18)14-23(30)31)13-21(15-27)29-24(32)25(28)10-2-1-3-11-25/h4-9,12,21H,1-3,10-11,13-14,16,28H2,(H,29,32)/t21-/m0/s1 QYHCMLWIBDNPKC-NRFANRHFSA-N 657993 (S)-1-Amino-N-(1-cyano-2-(2-(4-fluorophenyl)-3-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl)ethyl)cyclohexane-1-carboxamide::US20240083888, Compound 58 Dipeptidyl peptidase 1 17.0 US Patent 10.7270/Q22F7SQ9 US20240083888 Hao, X; Gong, S; Shen, D; Du, X Reistone Biopharma Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=657993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=657993&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8 1387518 Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 InChI=1S/C23H24N4O4/c1-27-19-12-17(7-8-20(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)21-14-25-9-2-10-30-21/h3-8,12,18,21,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,21-/m0/s1 AEXFXNFMSAAELR-RXVVDRJESA-N 50195235 CHEMBL3900409::US10287258, Example 2::US10669245, Example 2::US11117874, Example 2::US11655221, Example 2::US11680049, Example 2::US20230278969, Example 2::US20240083888, Compound AZD7986 Dipeptidyl peptidase 1 7.69 US Patent 10.7270/Q22F7SQ9 US20240083888 Hao, X; Gong, S; Shen, D; Du, X Reistone Biopharma Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195235&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search 118253852 375977090 CHEMBL3900409 1 MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 1K3B,2DJF,2DJG,4CDC,4CDD,4CDE,4CDF,4OEL,4OEM,6IC5,6IC6,6IC7,6RN6,6RN7,6RN9,6RNE,6RNI Dipeptidyl peptidase 1 CATC_HUMAN P53634 A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8