BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 259298 Fc1cccc(F)c1NC(=O)c1ccc(s1)-c1cc(ccc1Cl)C(F)(F)F InChI=1S/C18H9ClF5NOS/c19-11-5-4-9(18(22,23)24)8-10(11)14-6-7-15(27-14)17(26)25-16-12(20)2-1-3-13(16)21/h1-8H,(H,25,26) ZYPDOLOIVUQBHA-UHFFFAOYSA-N 128384 US8802721, 1 Interleukin-2 3 US Patent 10.7270/Q2CN72M4 aid1800599 US8802721 Sun, L; Chen, S; Jiang, J; Xia, Z; Xie, Y; Yu, C Synta Pharmaceuticals Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=128384 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=128384&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 11553502 225154726 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 259299 Cc1cnccc1NC(=O)c1ccc(s1)-c1cc(ccc1Cl)C(F)(F)F InChI=1S/C18H12ClF3N2OS/c1-10-9-23-7-6-14(10)24-17(25)16-5-4-15(26-16)12-8-11(18(20,21)22)2-3-13(12)19/h2-9H,1H3,(H,23,24,25) GZQRIUNYAKGDOX-UHFFFAOYSA-N 128385 US8802721, 2 Interleukin-2 14 US Patent 10.7270/Q2CN72M4 aid1800599 US8802721 Sun, L; Chen, S; Jiang, J; Xia, Z; Xie, Y; Yu, C Synta Pharmaceuticals Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=128385 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=128385&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 11545718 225154727 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 259300 COC(=O)c1ccc(C)c(c1)-c1ccc(s1)C(=O)Nc1c(F)cccc1F InChI=1S/C20H15F2NO3S/c1-11-6-7-12(20(25)26-2)10-13(11)16-8-9-17(27-16)19(24)23-18-14(21)4-3-5-15(18)22/h3-10H,1-2H3,(H,23,24) CYEJEUFHAKJVMF-UHFFFAOYSA-N 128386 US8802721, 3 Interleukin-2 6.4 US Patent 10.7270/Q2CN72M4 aid1800599 US8802721 Sun, L; Chen, S; Jiang, J; Xia, Z; Xie, Y; Yu, C Synta Pharmaceuticals Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=128386 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=128386&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 11653926 225154728 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 259301 COC(=O)c1ccc(C)c(c1)-c1ccc(s1)C(=O)Nc1ccncc1C InChI=1S/C20H18N2O3S/c1-12-4-5-14(20(24)25-3)10-15(12)17-6-7-18(26-17)19(23)22-16-8-9-21-11-13(16)2/h4-11H,1-3H3,(H,21,22,23) BAEBBDIFQSEKMY-UHFFFAOYSA-N 128387 US8802721, 4 Interleukin-2 58.5 US Patent 10.7270/Q2CN72M4 aid1800599 US8802721 Sun, L; Chen, S; Jiang, J; Xia, Z; Xie, Y; Yu, C Synta Pharmaceuticals Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=128387 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=128387&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 11710361 225154729 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 259302 Fc1cccc(F)c1C(=O)Nc1ccc(s1)-c1cccc(c1)C(F)(F)F InChI=1S/C18H10F5NOS/c19-12-5-2-6-13(20)16(12)17(25)24-15-8-7-14(26-15)10-3-1-4-11(9-10)18(21,22)23/h1-9H,(H,24,25) UELRFSJDXDLMOI-UHFFFAOYSA-N 128388 US8802721, 117 Interleukin-2 16.5 US Patent 10.7270/Q2CN72M4 aid1800599 US8802721 Sun, L; Chen, S; Jiang, J; Xia, Z; Xie, Y; Yu, C Synta Pharmaceuticals Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=128388 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=128388&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 58703377 225154730 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 259303 COC(=O)c1ccc(C)c(c1)-c1ccc(NC(=O)c2c(F)cccc2F)s1 InChI=1S/C20H15F2NO3S/c1-11-6-7-12(20(25)26-2)10-13(11)16-8-9-17(27-16)23-19(24)18-14(21)4-3-5-15(18)22/h3-10H,1-2H3,(H,23,24) GQZXIYHNNGWDGX-UHFFFAOYSA-N 128389 US8802721, 118 Interleukin-2 103.6 US Patent 10.7270/Q2CN72M4 aid1800599 US8802721 Sun, L; Chen, S; Jiang, J; Xia, Z; Xie, Y; Yu, C Synta Pharmaceuticals Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=128389 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=128389&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 58703396 225154731 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 259304 Cc1ccc(cc1-c1ccc(NC(=O)c2c(F)cccc2F)s1)-c1ncco1 InChI=1S/C21H14F2N2O2S/c1-12-5-6-13(21-24-9-10-27-21)11-14(12)17-7-8-18(28-17)25-20(26)19-15(22)3-2-4-16(19)23/h2-11H,1H3,(H,25,26) RMTLHQQETULZDK-UHFFFAOYSA-N 128390 US8802721, 119 Interleukin-2 94.8 US Patent 10.7270/Q2CN72M4 aid1800599 US8802721 Sun, L; Chen, S; Jiang, J; Xia, Z; Xie, Y; Yu, C Synta Pharmaceuticals Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=128390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=128390&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 11639836 225154732 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 259305 COC(=O)c1cccc(c1)-c1sc(NC(=O)c2c(F)cccc2F)cc1C InChI=1S/C20H15F2NO3S/c1-11-9-16(23-19(24)17-14(21)7-4-8-15(17)22)27-18(11)12-5-3-6-13(10-12)20(25)26-2/h3-10H,1-2H3,(H,23,24) WQSDCURSTYANJT-UHFFFAOYSA-N 128391 US8802721, 120 Interleukin-2 87 US Patent 10.7270/Q2CN72M4 aid1800599 US8802721 Sun, L; Chen, S; Jiang, J; Xia, Z; Xie, Y; Yu, C Synta Pharmaceuticals Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=128391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=128391&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 58703393 225154733 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 259306 Fc1cccc(F)c1C(=O)Nc1ccc(s1)-c1cccc(c1)-c1cnco1 InChI=1S/C20H12F2N2O2S/c21-14-5-2-6-15(22)19(14)20(25)24-18-8-7-17(27-18)13-4-1-3-12(9-13)16-10-23-11-26-16/h1-11H,(H,24,25) UFQUDEDAOLWTRO-UHFFFAOYSA-N 128392 US8802721, 121 Interleukin-2 164.4 US Patent 10.7270/Q2CN72M4 aid1800599 US8802721 Sun, L; Chen, S; Jiang, J; Xia, Z; Xie, Y; Yu, C Synta Pharmaceuticals Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=128392 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=128392&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 58703376 225154734 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467548 CC1(C)C[C@H](C[C@H]2CCCN12)Nc1nc(Nc2ccc3OC(C)(C)c4nnnn4-c3c2)ncc1F InChI=1S/C24H30FN9O/c1-23(2)12-15(10-16-6-5-9-33(16)23)27-20-17(25)13-26-22(29-20)28-14-7-8-19-18(11-14)34-21(30-31-32-34)24(3,4)35-19/h7-8,11,13,15-16H,5-6,9-10,12H2,1-4H3,(H2,26,27,28,29)/t15-,16+/m0/s1 WKEZTKWVWOCIOX-JKSUJKDBSA-N 160829 US9682976, 1::US9682976, 102 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=160829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=160829&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89854044 355042095 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467549 CC1(C)C[C@@H](C[C@H]2CCCN12)Nc1nc(Nc2ccc3OC(C)(C)c4nnnn4-c3c2)ncc1F InChI=1S/C24H30FN9O/c1-23(2)12-15(10-16-6-5-9-33(16)23)27-20-17(25)13-26-22(29-20)28-14-7-8-19-18(11-14)34-21(30-31-32-34)24(3,4)35-19/h7-8,11,13,15-16H,5-6,9-10,12H2,1-4H3,(H2,26,27,28,29)/t15-,16-/m1/s1 WKEZTKWVWOCIOX-HZPDHXFCSA-N 160830 US9682976, 2 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=160830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=160830&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 132471152 355042096 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467550 CC1(C)C[C@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc3OC(C)(C)c4nnnn4-c3c2)ncc1F InChI=1S/C24H30FN9O/c1-23(2)12-15(10-16-6-5-9-33(16)23)27-20-17(25)13-26-22(29-20)28-14-7-8-19-18(11-14)34-21(30-31-32-34)24(3,4)35-19/h7-8,11,13,15-16H,5-6,9-10,12H2,1-4H3,(H2,26,27,28,29)/t15-,16-/m0/s1 WKEZTKWVWOCIOX-HOTGVXAUSA-N 160831 US9682976, 3 Interleukin-2 <1000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=160831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=160831&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 132471153 355042097 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467551 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc3OC(C)(C)c4nnnn4-c3c2)ncc1F InChI=1S/C24H30FN9O/c1-23(2)12-15(10-16-6-5-9-33(16)23)27-20-17(25)13-26-22(29-20)28-14-7-8-19-18(11-14)34-21(30-31-32-34)24(3,4)35-19/h7-8,11,13,15-16H,5-6,9-10,12H2,1-4H3,(H2,26,27,28,29)/t15-,16+/m1/s1 WKEZTKWVWOCIOX-CVEARBPZSA-N 160833 US9682976, 4 Interleukin-2 <10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=160833 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=160833&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811639 355042098 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467552 CC1(C)CC(CC2CCCN12)Nc1nc(Nc2cc(F)c3OC(C)(C)c4nnnn4-c3c2)ncc1F InChI=1S/C24H29F2N9O/c1-23(2)11-14(8-15-6-5-7-34(15)23)28-20-17(26)12-27-22(30-20)29-13-9-16(25)19-18(10-13)35-21(31-32-33-35)24(3,4)36-19/h9-10,12,14-15H,5-8,11H2,1-4H3,(H2,27,28,29,30) JVXBWQBFQUVQMC-UHFFFAOYSA-N 160834 US9682976, 5 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=160834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=160834&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 132471154 355042099 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467553 CC(C)N1CCC(CC1)Oc1ccc(Nc2ncc(F)c(NC3CC4CCCN4C(C)(C)C3)n2)cc1OC(F)F InChI=1S/C29H41F3N6O2/c1-18(2)37-12-9-22(10-13-37)39-24-8-7-19(15-25(24)40-27(31)32)35-28-33-17-23(30)26(36-28)34-20-14-21-6-5-11-38(21)29(3,4)16-20/h7-8,15,17-18,20-22,27H,5-6,9-14,16H2,1-4H3,(H2,33,34,35,36) HOCYSKMLCFDQRG-UHFFFAOYSA-N 160835 US9682976, 6 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=160835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=160835&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89863870 355042100 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467554 CC(C)N1CCC(CC1)Oc1ccc(Nc2ncc(F)c(N[C@H]3C[C@H]4CCCN4C(C)(C)C3)n2)cc1OC(F)F InChI=1S/C29H41F3N6O2/c1-18(2)37-12-9-22(10-13-37)39-24-8-7-19(15-25(24)40-27(31)32)35-28-33-17-23(30)26(36-28)34-20-14-21-6-5-11-38(21)29(3,4)16-20/h7-8,15,17-18,20-22,27H,5-6,9-14,16H2,1-4H3,(H2,33,34,35,36)/t20-,21+/m0/s1 HOCYSKMLCFDQRG-LEWJYISDSA-N 160836 US9682976, 7 Interleukin-2 <10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=160836 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=160836&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 118461261 355042101 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467555 CC(C)N1CCC(CC1)Oc1ccc(Nc2ncc(F)c(N[C@@H]3C[C@H]4CCCN4C(C)(C)C3)n2)cc1OC(F)F InChI=1S/C29H41F3N6O2/c1-18(2)37-12-9-22(10-13-37)39-24-8-7-19(15-25(24)40-27(31)32)35-28-33-17-23(30)26(36-28)34-20-14-21-6-5-11-38(21)29(3,4)16-20/h7-8,15,17-18,20-22,27H,5-6,9-14,16H2,1-4H3,(H2,33,34,35,36)/t20-,21-/m1/s1 HOCYSKMLCFDQRG-NHCUHLMSSA-N 160837 US9682976, 8 Interleukin-2 <1000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=160837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=160837&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 132471155 355042102 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467556 CC(C)N1CCC(CC1)Oc1ccc(Nc2ncc(F)c(N[C@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1OC(F)F InChI=1S/C29H41F3N6O2/c1-18(2)37-12-9-22(10-13-37)39-24-8-7-19(15-25(24)40-27(31)32)35-28-33-17-23(30)26(36-28)34-20-14-21-6-5-11-38(21)29(3,4)16-20/h7-8,15,17-18,20-22,27H,5-6,9-14,16H2,1-4H3,(H2,33,34,35,36)/t20-,21-/m0/s1 HOCYSKMLCFDQRG-SFTDATJTSA-N 160838 US9682976, 9 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=160838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=160838&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 132471156 355042103 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467557 CC(C)N1CCC(CC1)Oc1ccc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1OC(F)F InChI=1S/C29H41F3N6O2/c1-18(2)37-12-9-22(10-13-37)39-24-8-7-19(15-25(24)40-27(31)32)35-28-33-17-23(30)26(36-28)34-20-14-21-6-5-11-38(21)29(3,4)16-20/h7-8,15,17-18,20-22,27H,5-6,9-14,16H2,1-4H3,(H2,33,34,35,36)/t20-,21+/m1/s1 HOCYSKMLCFDQRG-RTWAWAEBSA-N 160839 US9682976, 10 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=160839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=160839&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 118461262 355042104 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467558 COc1cc(Nc2ncc(F)c(N[C@H]3C[C@H]4CCCN4C(C)(C)C3)n2)cc(c1)-n1nnnc1C InChI=1S/C23H30FN9O/c1-14-29-30-31-33(14)18-8-15(10-19(11-18)34-4)27-22-25-13-20(24)21(28-22)26-16-9-17-6-5-7-32(17)23(2,3)12-16/h8,10-11,13,16-17H,5-7,9,12H2,1-4H3,(H2,25,26,27,28)/t16-,17+/m0/s1 OZVOSBUTLKYDBR-DLBZAZTESA-N 160840 US9682976, 11 Interleukin-2 <10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=160840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=160840&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 132471157 355042105 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467559 COc1cc(Nc2ncc(F)c(N[C@@H]3C[C@H]4CCCN4C(C)(C)C3)n2)cc(c1)-n1nnnc1C InChI=1S/C23H30FN9O/c1-14-29-30-31-33(14)18-8-15(10-19(11-18)34-4)27-22-25-13-20(24)21(28-22)26-16-9-17-6-5-7-32(17)23(2,3)12-16/h8,10-11,13,16-17H,5-7,9,12H2,1-4H3,(H2,25,26,27,28)/t16-,17-/m1/s1 OZVOSBUTLKYDBR-IAGOWNOFSA-N 160842 US9682976, 12 Interleukin-2 <1000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=160842 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=160842&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 132471158 355042106 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467560 COc1cc(Nc2ncc(F)c(N[C@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc(c1)-n1nnnc1C InChI=1S/C23H30FN9O/c1-14-29-30-31-33(14)18-8-15(10-19(11-18)34-4)27-22-25-13-20(24)21(28-22)26-16-9-17-6-5-7-32(17)23(2,3)12-16/h8,10-11,13,16-17H,5-7,9,12H2,1-4H3,(H2,25,26,27,28)/t16-,17-/m0/s1 OZVOSBUTLKYDBR-IRXDYDNUSA-N 160843 US9682976, 13 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=160843 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=160843&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 132471159 355042107 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467561 COc1cc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc(c1)-n1nnnc1C InChI=1S/C23H30FN9O/c1-14-29-30-31-33(14)18-8-15(10-19(11-18)34-4)27-22-25-13-20(24)21(28-22)26-16-9-17-6-5-7-32(17)23(2,3)12-16/h8,10-11,13,16-17H,5-7,9,12H2,1-4H3,(H2,25,26,27,28)/t16-,17+/m1/s1 OZVOSBUTLKYDBR-SJORKVTESA-N 160845 US9682976, 14 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=160845 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=160845&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 132471160 355042109 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467562 Cc1nnnn1-c1cc(Nc2ncc(F)c(NC3CC4CCCN4C(C)(C)C3)n2)cnc1C InChI=1S/C22H29FN10/c1-13-19(33-14(2)29-30-31-33)9-16(11-24-13)27-21-25-12-18(23)20(28-21)26-15-8-17-6-5-7-32(17)22(3,4)10-15/h9,11-12,15,17H,5-8,10H2,1-4H3,(H2,25,26,27,28) PBWMFQBNKZWOFO-UHFFFAOYSA-N 160847 US9682976, 15 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=160847 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=160847&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 132471161 355042111 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467563 Cn1nnn(-c2cc(Nc3ncc(F)c(NC4CC5CCCN5C(C)(C)C4)n3)c(F)cc2C2CC2)c1=O InChI=1S/C25H31F2N9O/c1-25(2)12-15(9-16-5-4-8-35(16)25)29-22-19(27)13-28-23(31-22)30-20-11-21(36-24(37)34(3)32-33-36)17(10-18(20)26)14-6-7-14/h10-11,13-16H,4-9,12H2,1-3H3,(H2,28,29,30,31) JFAIVAMGMCTLMH-UHFFFAOYSA-N 160848 US9682976, 16 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=160848 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=160848&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 78166963 355042112 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467564 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@H]4C[C@H]5CCCN5C(C)(C)C4)n3)c(F)cc2C2CC2)c1=O InChI=1S/C25H31F2N9O/c1-25(2)12-15(9-16-5-4-8-35(16)25)29-22-19(27)13-28-23(31-22)30-20-11-21(36-24(37)34(3)32-33-36)17(10-18(20)26)14-6-7-14/h10-11,13-16H,4-9,12H2,1-3H3,(H2,28,29,30,31)/t15-,16+/m0/s1 JFAIVAMGMCTLMH-JKSUJKDBSA-N 161048 US9682976, 17 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161048&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811824 355042113 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467565 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@H]5CCCN5C(C)(C)C4)n3)c(F)cc2C2CC2)c1=O InChI=1S/C25H31F2N9O/c1-25(2)12-15(9-16-5-4-8-35(16)25)29-22-19(27)13-28-23(31-22)30-20-11-21(36-24(37)34(3)32-33-36)17(10-18(20)26)14-6-7-14/h10-11,13-16H,4-9,12H2,1-3H3,(H2,28,29,30,31)/t15-,16-/m1/s1 JFAIVAMGMCTLMH-HZPDHXFCSA-N 161049 US9682976, 18 Interleukin-2 <1000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161049&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 90437671 355042114 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467566 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2C2CC2)c1=O InChI=1S/C25H31F2N9O/c1-25(2)12-15(9-16-5-4-8-35(16)25)29-22-19(27)13-28-23(31-22)30-20-11-21(36-24(37)34(3)32-33-36)17(10-18(20)26)14-6-7-14/h10-11,13-16H,4-9,12H2,1-3H3,(H2,28,29,30,31)/t15-,16-/m0/s1 JFAIVAMGMCTLMH-HOTGVXAUSA-N 161053 US9682976, 19 Interleukin-2 <1000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161053&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 90418853 355042115 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467567 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2C2CC2)c1=O InChI=1S/C25H31F2N9O/c1-25(2)12-15(9-16-5-4-8-35(16)25)29-22-19(27)13-28-23(31-22)30-20-11-21(36-24(37)34(3)32-33-36)17(10-18(20)26)14-6-7-14/h10-11,13-16H,4-9,12H2,1-3H3,(H2,28,29,30,31)/t15-,16+/m1/s1 JFAIVAMGMCTLMH-CVEARBPZSA-N 161054 US9682976, 20::US9682976, 21 Interleukin-2 <10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161054&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71745096 355042116 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467568 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2C2CC2)c1=O InChI=1S/C25H31F2N9O/c1-25(2)12-15(9-16-5-4-8-35(16)25)29-22-19(27)13-28-23(31-22)30-20-11-21(36-24(37)34(3)32-33-36)17(10-18(20)26)14-6-7-14/h10-11,13-16H,4-9,12H2,1-3H3,(H2,28,29,30,31)/t15-,16+/m1/s1 JFAIVAMGMCTLMH-CVEARBPZSA-N 161054 US9682976, 20::US9682976, 21 Interleukin-2 <10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161054&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71745096 355042116 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467569 COc1cc(F)c(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnn(C)c1=O InChI=1S/C23H29F2N9O2/c1-23(2)11-13(8-14-6-5-7-33(14)23)27-20-16(25)12-26-21(29-20)28-17-10-18(19(36-4)9-15(17)24)34-22(35)32(3)30-31-34/h9-10,12-14H,5-8,11H2,1-4H3,(H2,26,27,28,29)/t13-,14+/m1/s1 FJBPBBUHADXTHW-KGLIPLIRSA-N 161068 US9682976, 22 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161068&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811823 355042117 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467570 CC(C)Oc1cc(F)c(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnn(C)c1=O InChI=1S/C25H33F2N9O2/c1-14(2)38-21-10-17(26)19(11-20(21)36-24(37)34(5)32-33-36)30-23-28-13-18(27)22(31-23)29-15-9-16-7-6-8-35(16)25(3,4)12-15/h10-11,13-16H,6-9,12H2,1-5H3,(H2,28,29,30,31)/t15-,16+/m1/s1 NIAPQRFFZKSUBZ-CVEARBPZSA-N 161069 US9682976, 23 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161069&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811822 355042118 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467571 Fc1cnc(Nc2cc(c(cc2F)C2CC2)-n2cnnn2)nc1NC1CCN2CCCC2C1 InChI=1S/C22H25F2N9/c23-17-9-16(13-3-4-13)20(33-12-26-30-31-33)10-19(17)28-22-25-11-18(24)21(29-22)27-14-5-7-32-6-1-2-15(32)8-14/h9-15H,1-8H2,(H2,25,27,28,29) OALUUBVHRFOODL-UHFFFAOYSA-N 161070 US9682976, 24 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161070&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89853952 355042119 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467572 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4CCN5C(CCC5(C)C)C4)n3)c(F)cc2C2CC2)c1=O InChI=1S/C25H31F2N9O/c1-25(2)8-6-16-10-15(7-9-35(16)25)29-22-19(27)13-28-23(31-22)30-20-12-21(36-24(37)34(3)32-33-36)17(11-18(20)26)14-4-5-14/h11-16H,4-10H2,1-3H3,(H2,28,29,30,31)/t15-,16?/m1/s1 YMPMUCHDYTYALL-AAFJCEBUSA-N 161071 US9682976, 25 Interleukin-2 <10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161071&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 132471162 355042120 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467573 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@H]4CCN5C(CCC5(C)C)C4)n3)c(F)cc2C2CC2)c1=O InChI=1S/C25H31F2N9O/c1-25(2)8-6-16-10-15(7-9-35(16)25)29-22-19(27)13-28-23(31-22)30-20-12-21(36-24(37)34(3)32-33-36)17(11-18(20)26)14-4-5-14/h11-16H,4-10H2,1-3H3,(H2,28,29,30,31)/t15-,16?/m0/s1 YMPMUCHDYTYALL-VYRBHSGPSA-N 161072 US9682976, 26 Interleukin-2 <10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161072&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 132471163 355042121 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467574 Cn1nnn(-c2cc(Nc3ncc(F)c(NC4CCN5CCCC5C4)n3)c(F)cc2C2CC2)c1=O InChI=1S/C23H27F2N9O/c1-32-23(35)34(31-30-32)20-11-19(17(24)10-16(20)13-4-5-13)28-22-26-12-18(25)21(29-22)27-14-6-8-33-7-2-3-15(33)9-14/h10-15H,2-9H2,1H3,(H2,26,27,28,29) GAKGCPZUYNJSSA-UHFFFAOYSA-N 161073 US9682976, 27::US9682976, 29 Interleukin-2 <10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161073&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811349 355042122 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467575 Cc1nnnn1-c1cc(Nc2ncc(F)c(NC3CCN4CCCC4C3)n2)c(F)cc1C1CC1 InChI=1S/C23H27F2N9/c1-13-30-31-32-34(13)21-11-20(18(24)10-17(21)14-4-5-14)28-23-26-12-19(25)22(29-23)27-15-6-8-33-7-2-3-16(33)9-15/h10-12,14-16H,2-9H2,1H3,(H2,26,27,28,29) JRJFGKQZUPUREF-UHFFFAOYSA-N 161074 US9682976, 28 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161074&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811350 355042123 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467576 Cn1nnn(-c2cc(Nc3ncc(F)c(NC4CCN5CCCC5C4)n3)c(F)cc2C2CC2)c1=O InChI=1S/C23H27F2N9O/c1-32-23(35)34(31-30-32)20-11-19(17(24)10-16(20)13-4-5-13)28-22-26-12-18(25)21(29-22)27-14-6-8-33-7-2-3-15(33)9-14/h10-15H,2-9H2,1H3,(H2,26,27,28,29) GAKGCPZUYNJSSA-UHFFFAOYSA-N 161073 US9682976, 27::US9682976, 29 Interleukin-2 <10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161073&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811349 355042122 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467577 Cn1nnn(-c2cc(Nc3ncc(F)c(NC4CC5CCC(C)(C)N5C(=O)C4)n3)c(F)cc2C2CC2)c1=O InChI=1S/C25H29F2N9O2/c1-25(2)7-6-15-8-14(9-21(37)35(15)25)29-22-18(27)12-28-23(31-22)30-19-11-20(36-24(38)34(3)32-33-36)16(10-17(19)26)13-4-5-13/h10-15H,4-9H2,1-3H3,(H2,28,29,30,31) XNMBNYRPARHBJJ-UHFFFAOYSA-N 161076 US9682976, 30 Interleukin-2 >10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161076&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 132471164 355042124 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467578 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCC(=O)N5C(C)(C)C4)n3)c(F)cc2C2CC2)c1=O InChI=1S/C25H29F2N9O2/c1-25(2)11-14(8-15-6-7-21(37)35(15)25)29-22-18(27)12-28-23(31-22)30-19-10-20(36-24(38)34(3)32-33-36)16(9-17(19)26)13-4-5-13/h9-10,12-15H,4-8,11H2,1-3H3,(H2,28,29,30,31)/t14-,15+/m1/s1 XHCBBQOBCSQZKL-CABCVRRESA-N 161077 US9682976, 31 Interleukin-2 <10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161077&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89863988 355042125 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467579 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@H]4C[C@@H]5CCC(=O)N5C(C)(C)C4)n3)c(F)cc2C2CC2)c1=O InChI=1S/C25H29F2N9O2/c1-25(2)11-14(8-15-6-7-21(37)35(15)25)29-22-18(27)12-28-23(31-22)30-19-10-20(36-24(38)34(3)32-33-36)16(9-17(19)26)13-4-5-13/h9-10,12-15H,4-8,11H2,1-3H3,(H2,28,29,30,31)/t14-,15-/m0/s1 XHCBBQOBCSQZKL-GJZGRUSLSA-N 161078 US9682976, 32 Interleukin-2 <10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161078&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89863851 355042126 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467580 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@H]5CCC(=O)N5C(C)(C)C4)n3)c(F)cc2C2CC2)c1=O InChI=1S/C25H29F2N9O2/c1-25(2)11-14(8-15-6-7-21(37)35(15)25)29-22-18(27)12-28-23(31-22)30-19-10-20(36-24(38)34(3)32-33-36)16(9-17(19)26)13-4-5-13/h9-10,12-15H,4-8,11H2,1-3H3,(H2,28,29,30,31)/t14-,15-/m1/s1 XHCBBQOBCSQZKL-HUUCEWRRSA-N 161079 US9682976, 33 Interleukin-2 <10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161079&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 132471165 355042127 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467581 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4CCN5[C@H](CCC5(C)C)C4)n3)c(F)cc2C2CC2)c1=O InChI=1S/C25H31F2N9O/c1-25(2)8-6-16-10-15(7-9-35(16)25)29-22-19(27)13-28-23(31-22)30-20-12-21(36-24(37)34(3)32-33-36)17(11-18(20)26)14-4-5-14/h11-16H,4-10H2,1-3H3,(H2,28,29,30,31)/t15-,16-/m1/s1 YMPMUCHDYTYALL-HZPDHXFCSA-N 161080 US9682976, 34 Interleukin-2 <10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161080 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161080&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 132471166 355042128 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467582 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@H]4CCN5[C@H](CCC5(C)C)C4)n3)c(F)cc2C2CC2)c1=O InChI=1S/C25H31F2N9O/c1-25(2)8-6-16-10-15(7-9-35(16)25)29-22-19(27)13-28-23(31-22)30-20-12-21(36-24(37)34(3)32-33-36)17(11-18(20)26)14-4-5-14/h11-16H,4-10H2,1-3H3,(H2,28,29,30,31)/t15-,16+/m0/s1 YMPMUCHDYTYALL-JKSUJKDBSA-N 161081 US9682976, 35 Interleukin-2 <10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161081&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 132471167 355042129 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467583 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4CCN5[C@@H](CCC5(C)C)C4)n3)c(F)cc2C2CC2)c1=O InChI=1S/C25H31F2N9O/c1-25(2)8-6-16-10-15(7-9-35(16)25)29-22-19(27)13-28-23(31-22)30-20-12-21(36-24(37)34(3)32-33-36)17(11-18(20)26)14-4-5-14/h11-16H,4-10H2,1-3H3,(H2,28,29,30,31)/t15-,16+/m1/s1 YMPMUCHDYTYALL-CVEARBPZSA-N 161082 US9682976, 36 Interleukin-2 <10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161082&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 132471168 355042130 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467584 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@H]4CCN5[C@@H](CCC5(C)C)C4)n3)c(F)cc2C2CC2)c1=O InChI=1S/C25H31F2N9O/c1-25(2)8-6-16-10-15(7-9-35(16)25)29-22-19(27)13-28-23(31-22)30-20-12-21(36-24(37)34(3)32-33-36)17(11-18(20)26)14-4-5-14/h11-16H,4-10H2,1-3H3,(H2,28,29,30,31)/t15-,16-/m0/s1 YMPMUCHDYTYALL-HOTGVXAUSA-N 161083 US9682976, 37 Interleukin-2 <10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161083 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161083&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 132471169 355042131 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467585 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@H]4CC5CCCN5C(C)(C)C4)n3)ccc2OC2COC2)c1=O InChI=1S/C25H32FN9O3/c1-25(2)11-16(9-17-5-4-8-34(17)25)28-22-19(26)12-27-23(30-22)29-15-6-7-21(38-18-13-37-14-18)20(10-15)35-24(36)33(3)31-32-35/h6-7,10,12,16-18H,4-5,8-9,11,13-14H2,1-3H3,(H2,27,28,29,30)/t16-,17?/m0/s1 HIJUKDHGAOXGAM-BHWOMJMDSA-N 161084 US9682976, 38 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161084&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 132471170 355042132 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467586 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4CC5CCCN5C(C)(C)C4)n3)ccc2OC2COC2)c1=O InChI=1S/C25H32FN9O3/c1-25(2)11-16(9-17-5-4-8-34(17)25)28-22-19(26)12-27-23(30-22)29-15-6-7-21(38-18-13-37-14-18)20(10-15)35-24(36)33(3)31-32-35/h6-7,10,12,16-18H,4-5,8-9,11,13-14H2,1-3H3,(H2,27,28,29,30)/t16-,17?/m1/s1 HIJUKDHGAOXGAM-TZHYSIJRSA-N 161086 US9682976, 39 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161086&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 132471171 355042134 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467587 Cn1nnn(-c2cc(Nc3ncc(F)c(NC4CC5CCCN5C(C)(C)C4)n3)ccc2OC2COC2)c1=O InChI=1S/C25H32FN9O3/c1-25(2)11-16(9-17-5-4-8-34(17)25)28-22-19(26)12-27-23(30-22)29-15-6-7-21(38-18-13-37-14-18)20(10-15)35-24(36)33(3)31-32-35/h6-7,10,12,16-18H,4-5,8-9,11,13-14H2,1-3H3,(H2,27,28,29,30) HIJUKDHGAOXGAM-UHFFFAOYSA-N 161100 US9682976, 40 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161100 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161100&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811391 355042135 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467588 CC1(C)CC(CC2CCCN12)Nc1nc(Nc2ccc(OC3CCOCC3)c(c2)C#N)ncc1F InChI=1S/C26H33FN6O2/c1-26(2)14-19(13-20-4-3-9-33(20)26)30-24-22(27)16-29-25(32-24)31-18-5-6-23(17(12-18)15-28)35-21-7-10-34-11-8-21/h5-6,12,16,19-21H,3-4,7-11,13-14H2,1-2H3,(H2,29,30,31,32) SZGIVHKLVAZLTN-UHFFFAOYSA-N 161107 US9682976, 41 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161107&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811392 355042136 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467589 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@H]4C[C@@H]5CC(F)(F)CN5C(C)(C)C4)n3)c(F)cc2C2CC2)c1=O InChI=1S/C25H29F4N9O/c1-24(2)9-14(6-15-10-25(28,29)12-37(15)24)31-21-18(27)11-30-22(33-21)32-19-8-20(38-23(39)36(3)34-35-38)16(7-17(19)26)13-4-5-13/h7-8,11,13-15H,4-6,9-10,12H2,1-3H3,(H2,30,31,32,33)/t14-,15+/m0/s1 KXTUEBXYMDBGJS-LSDHHAIUSA-N 161123 US9682976, 42 Interleukin-2 <10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161123&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811393 355042137 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467590 CC1(C)C[C@H](C[C@@H]2CC(F)(F)CN12)Nc1nc(Nc2cc(c(cc2F)C2CC2)-n2cnnn2)ncc1F InChI=1S/C24H27F4N9/c1-23(2)8-14(5-15-9-24(27,28)11-36(15)23)31-21-18(26)10-29-22(33-21)32-19-7-20(37-12-30-34-35-37)16(6-17(19)25)13-3-4-13/h6-7,10,12-15H,3-5,8-9,11H2,1-2H3,(H2,29,31,32,33)/t14-,15+/m0/s1 XLRKAEAQGYVMRK-LSDHHAIUSA-N 161125 US9682976, 43 Interleukin-2 <10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161125&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811394 355042138 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467591 Cc1ccc(Nc2ncc(F)c(N[C@H]3C[C@@H]4CC(F)(F)CN4C(C)(C)C3)n2)cc1C#N InChI=1S/C22H25F3N6/c1-13-4-5-15(6-14(13)10-26)29-20-27-11-18(23)19(30-20)28-16-7-17-9-22(24,25)12-31(17)21(2,3)8-16/h4-6,11,16-17H,7-9,12H2,1-3H3,(H2,27,28,29,30)/t16-,17+/m0/s1 YGZCVKPYEPNSFE-DLBZAZTESA-N 161144 US9682976, 44 Interleukin-2 <10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161144&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89864062 355042140 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467592 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CC(F)(F)CN5C(C)(C)C4)n3)c(F)cc2C2CC2)c1=O InChI=1S/C25H29F4N9O/c1-24(2)9-14(6-15-10-25(28,29)12-37(15)24)31-21-18(27)11-30-22(33-21)32-19-8-20(38-23(39)36(3)34-35-38)16(7-17(19)26)13-4-5-13/h7-8,11,13-15H,4-6,9-10,12H2,1-3H3,(H2,30,31,32,33)/t14-,15-/m1/s1 KXTUEBXYMDBGJS-HUUCEWRRSA-N 161159 US9682976, 45 Interleukin-2 <10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161159&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811437 355042141 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467593 CC1(C)C[C@@H](C[C@@H]2CC(F)(F)CN12)Nc1nc(Nc2cc(c(cc2F)C2CC2)-n2cnnn2)ncc1F InChI=1S/C24H27F4N9/c1-23(2)8-14(5-15-9-24(27,28)11-36(15)23)31-21-18(26)10-29-22(33-21)32-19-7-20(37-12-30-34-35-37)16(6-17(19)25)13-3-4-13/h6-7,10,12-15H,3-5,8-9,11H2,1-2H3,(H2,29,31,32,33)/t14-,15-/m1/s1 XLRKAEAQGYVMRK-HUUCEWRRSA-N 161160 US9682976, 46 Interleukin-2 <1000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161160&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811438 355042142 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467594 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)ccc2O[C@H]2CCOC2)c1=O InChI=1S/C26H34FN9O3/c1-26(2)13-17(11-18-5-4-9-35(18)26)29-23-20(27)14-28-24(31-23)30-16-6-7-22(39-19-8-10-38-15-19)21(12-16)36-25(37)34(3)32-33-36/h6-7,12,14,17-19H,4-5,8-11,13,15H2,1-3H3,(H2,28,29,30,31)/t17-,18+,19+/m1/s1 LDUSGAYKQIOKIX-QYZOEREBSA-N 161161 US9682976, 47::US9682976, 50 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161161&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89863739 355042143 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467595 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)ccc2O[C@@H]2CCOC2)c1=O InChI=1S/C26H34FN9O3/c1-26(2)13-17(11-18-5-4-9-35(18)26)29-23-20(27)14-28-24(31-23)30-16-6-7-22(39-19-8-10-38-15-19)21(12-16)36-25(37)34(3)32-33-36/h6-7,12,14,17-19H,4-5,8-11,13,15H2,1-3H3,(H2,28,29,30,31)/t17-,18+,19-/m1/s1 LDUSGAYKQIOKIX-CEXWTWQISA-N 161162 US9682976, 48 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161162&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89863879 355042144 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467596 Cn1nnn(-c2cc(Nc3ncc(F)c(NC4CC5CCCN5C(C)(C)C4)n3)ccc2O[C@@H]2CCOC2)c1=O InChI=1S/C26H34FN9O3/c1-26(2)13-17(11-18-5-4-9-35(18)26)29-23-20(27)14-28-24(31-23)30-16-6-7-22(39-19-8-10-38-15-19)21(12-16)36-25(37)34(3)32-33-36/h6-7,12,14,17-19H,4-5,8-11,13,15H2,1-3H3,(H2,28,29,30,31)/t17?,18?,19-/m1/s1 LDUSGAYKQIOKIX-CTWPCTMYSA-N 161163 US9682976, 49 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161163&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811439 355042145 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467597 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)ccc2O[C@H]2CCOC2)c1=O InChI=1S/C26H34FN9O3/c1-26(2)13-17(11-18-5-4-9-35(18)26)29-23-20(27)14-28-24(31-23)30-16-6-7-22(39-19-8-10-38-15-19)21(12-16)36-25(37)34(3)32-33-36/h6-7,12,14,17-19H,4-5,8-11,13,15H2,1-3H3,(H2,28,29,30,31)/t17-,18+,19+/m1/s1 LDUSGAYKQIOKIX-QYZOEREBSA-N 161161 US9682976, 47::US9682976, 50 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161161&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89863739 355042143 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467598 Cn1nnn(-c2cc(Nc3ncc(F)c(NC4CC5CCCN5C(C)(C)C4)n3)ccc2OC2CCOCC2)c1=O InChI=1S/C27H36FN9O3/c1-27(2)15-18(13-19-5-4-10-36(19)27)30-24-21(28)16-29-25(32-24)31-17-6-7-23(40-20-8-11-39-12-9-20)22(14-17)37-26(38)35(3)33-34-37/h6-7,14,16,18-20H,4-5,8-13,15H2,1-3H3,(H2,29,30,31,32) VXTYPJFMGAKVJO-UHFFFAOYSA-N 161165 US9682976, 51 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161165&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811441 355042146 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467599 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)ccc2OC2CCOCC2)c1=O InChI=1S/C27H36FN9O3/c1-27(2)15-18(13-19-5-4-10-36(19)27)30-24-21(28)16-29-25(32-24)31-17-6-7-23(40-20-8-11-39-12-9-20)22(14-17)37-26(38)35(3)33-34-37/h6-7,14,16,18-20H,4-5,8-13,15H2,1-3H3,(H2,29,30,31,32)/t18-,19+/m1/s1 VXTYPJFMGAKVJO-MOPGFXCFSA-N 161166 US9682976, 52 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161166&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 90437679 355042147 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467600 CC1(C)CC(CC2CCCN12)Nc1nc(Nc2cc(c(cc2F)C2CC2)-n2cnnn2)ncc1F InChI=1S/C24H29F2N9/c1-24(2)11-15(8-16-4-3-7-34(16)24)29-22-19(26)12-27-23(31-22)30-20-10-21(35-13-28-32-33-35)17(9-18(20)25)14-5-6-14/h9-10,12-16H,3-8,11H2,1-2H3,(H2,27,29,30,31) JIAFMXJQYGDOSX-UHFFFAOYSA-N 161167 US9682976, 53 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161167 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161167&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811479 355042148 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467601 CC1(C)C[C@@H](C[C@H]2CCCN12)Nc1nc(Nc2cc(c(cc2F)C2CC2)-n2cnnn2)ncc1F InChI=1S/C24H29F2N9/c1-24(2)11-15(8-16-4-3-7-34(16)24)29-22-19(26)12-27-23(31-22)30-20-10-21(35-13-28-32-33-35)17(9-18(20)25)14-5-6-14/h9-10,12-16H,3-8,11H2,1-2H3,(H2,27,29,30,31)/t15-,16-/m1/s1 JIAFMXJQYGDOSX-HZPDHXFCSA-N 161168 US9682976, 54 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161168&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 132471172 355042149 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467602 CC1(C)C[C@H](C[C@@H]2CCCN12)Nc1nc(Nc2cc(c(cc2F)C2CC2)-n2cnnn2)ncc1F InChI=1S/C24H29F2N9/c1-24(2)11-15(8-16-4-3-7-34(16)24)29-22-19(26)12-27-23(31-22)30-20-10-21(35-13-28-32-33-35)17(9-18(20)25)14-5-6-14/h9-10,12-16H,3-8,11H2,1-2H3,(H2,27,29,30,31)/t15-,16-/m0/s1 JIAFMXJQYGDOSX-HOTGVXAUSA-N 161169 US9682976, 55 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161169&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 132471173 355042150 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467603 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2cc(c(cc2F)C2CC2)-n2cnnn2)ncc1C#N InChI=1S/C25H29FN10/c1-25(2)11-17(8-18-4-3-7-35(18)25)30-23-16(12-27)13-28-24(32-23)31-21-10-22(36-14-29-33-34-36)19(9-20(21)26)15-5-6-15/h9-10,13-15,17-18H,3-8,11H2,1-2H3,(H2,28,30,31,32)/t17-,18+/m1/s1 STUIMLNXDJJKEB-MSOLQXFVSA-N 161170 US9682976, 56 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161170&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89863872 355042151 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467604 CC1(C)C[C@@H](C[C@H]2CCCN12)Nc1nc(Nc2ccc(O[C@@H]3CCOC3)c(c2)C#N)ncc1F InChI=1S/C25H31FN6O2/c1-25(2)12-18(11-19-4-3-8-32(19)25)29-23-21(26)14-28-24(31-23)30-17-5-6-22(16(10-17)13-27)34-20-7-9-33-15-20/h5-6,10,14,18-20H,3-4,7-9,11-12,15H2,1-2H3,(H2,28,29,30,31)/t18-,19-,20-/m1/s1 OTPWEBUGLWNXLO-VAMGGRTRSA-N 161171 US9682976, 57 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161171&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 132471174 355042152 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467605 CC1(C)C[C@@H](C[C@H]2CCCN12)Nc1nc(Nc2ccc(O[C@H]3CCOC3)c(c2)C#N)ncc1F InChI=1S/C25H31FN6O2/c1-25(2)12-18(11-19-4-3-8-32(19)25)29-23-21(26)14-28-24(31-23)30-17-5-6-22(16(10-17)13-27)34-20-7-9-33-15-20/h5-6,10,14,18-20H,3-4,7-9,11-12,15H2,1-2H3,(H2,28,29,30,31)/t18-,19-,20+/m1/s1 OTPWEBUGLWNXLO-AQNXPRMDSA-N 161172 US9682976, 58 Interleukin-2 <10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161172 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161172&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 132471175 355042153 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467606 CC1(C)C[C@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(O[C@@H]3CCOC3)c(c2)C#N)ncc1F InChI=1S/C25H31FN6O2/c1-25(2)12-18(11-19-4-3-8-32(19)25)29-23-21(26)14-28-24(31-23)30-17-5-6-22(16(10-17)13-27)34-20-7-9-33-15-20/h5-6,10,14,18-20H,3-4,7-9,11-12,15H2,1-2H3,(H2,28,29,30,31)/t18-,19-,20+/m0/s1 OTPWEBUGLWNXLO-SLFFLAALSA-N 161173 US9682976, 59 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161173&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 132471176 355042154 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467607 CC1(C)C[C@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(O[C@H]3CCOC3)c(c2)C#N)ncc1F InChI=1S/C25H31FN6O2/c1-25(2)12-18(11-19-4-3-8-32(19)25)29-23-21(26)14-28-24(31-23)30-17-5-6-22(16(10-17)13-27)34-20-7-9-33-15-20/h5-6,10,14,18-20H,3-4,7-9,11-12,15H2,1-2H3,(H2,28,29,30,31)/t18-,19-,20-/m0/s1 OTPWEBUGLWNXLO-UFYCRDLUSA-N 161174 US9682976, 60 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161174 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161174&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 132471177 355042155 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467608 CC1(C)C[C@H](C[C@H]2CCCN12)Nc1nc(Nc2ccc(O[C@@H]3CCOC3)c(c2)C#N)ncc1F InChI=1S/C25H31FN6O2/c1-25(2)12-18(11-19-4-3-8-32(19)25)29-23-21(26)14-28-24(31-23)30-17-5-6-22(16(10-17)13-27)34-20-7-9-33-15-20/h5-6,10,14,18-20H,3-4,7-9,11-12,15H2,1-2H3,(H2,28,29,30,31)/t18-,19+,20+/m0/s1 OTPWEBUGLWNXLO-XUVXKRRUSA-N 161175 US9682976, 61 Interleukin-2 <1000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161175 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161175&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 132471178 355042156 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467609 CC1(C)C[C@H](C[C@H]2CCCN12)Nc1nc(Nc2ccc(O[C@H]3CCOC3)c(c2)C#N)ncc1F InChI=1S/C25H31FN6O2/c1-25(2)12-18(11-19-4-3-8-32(19)25)29-23-21(26)14-28-24(31-23)30-17-5-6-22(16(10-17)13-27)34-20-7-9-33-15-20/h5-6,10,14,18-20H,3-4,7-9,11-12,15H2,1-2H3,(H2,28,29,30,31)/t18-,19+,20-/m0/s1 OTPWEBUGLWNXLO-ZCNNSNEGSA-N 161176 US9682976, 62 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161176 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161176&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 132471179 355042157 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467610 CC1(C)CC(CC2CCCN12)Nc1nc(Nc2ccc(OC3COC3)c(c2)C#N)ncc1F InChI=1S/C24H29FN6O2/c1-24(2)10-17(9-18-4-3-7-31(18)24)28-22-20(25)12-27-23(30-22)29-16-5-6-21(15(8-16)11-26)33-19-13-32-14-19/h5-6,8,12,17-19H,3-4,7,9-10,13-14H2,1-2H3,(H2,27,28,29,30) HXCAJWLILGGKGO-UHFFFAOYSA-N 161177 US9682976, 63 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161177 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161177&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811483 355042158 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467611 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5C[C@@H](F)CN5C(C)(C)C4)n3)c(F)cc2C2CC2)c1=O InChI=1S/C25H30F3N9O/c1-25(2)10-15(7-16-6-14(26)12-36(16)25)30-22-19(28)11-29-23(32-22)31-20-9-21(37-24(38)35(3)33-34-37)17(8-18(20)27)13-4-5-13/h8-9,11,13-16H,4-7,10,12H2,1-3H3,(H2,29,30,31,32)/t14-,15-,16+/m1/s1 CQWAILPSZVCBCM-OAGGEKHMSA-N 161178 US9682976, 64 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161178&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811516 355042159 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467612 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@H]4C[C@@H]5C[C@H](F)CN5C(C)(C)C4)n3)c(F)cc2C2CC2)c1=O InChI=1S/C25H30F3N9O/c1-25(2)10-15(7-16-6-14(26)12-36(16)25)30-22-19(28)11-29-23(32-22)31-20-9-21(37-24(38)35(3)33-34-37)17(8-18(20)27)13-4-5-13/h8-9,11,13-16H,4-7,10,12H2,1-3H3,(H2,29,30,31,32)/t14-,15-,16-/m0/s1 CQWAILPSZVCBCM-JYJNAYRXSA-N 161179 US9682976, 65 Interleukin-2 <10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161179 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161179&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 132471180 355042160 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467613 Cn1nnn(-c2cc(Nc3ncc([N+]#[C-])c(N[C@H]4C[C@H]5CCCN5C(C)(C)C4)n3)c(F)cc2C2CC2)c1=O InChI=1S/C26H31FN10O/c1-26(2)13-16(10-17-6-5-9-36(17)26)30-23-21(28-3)14-29-24(32-23)31-20-12-22(37-25(38)35(4)33-34-37)18(11-19(20)27)15-7-8-15/h11-12,14-17H,5-10,13H2,1-2,4H3,(H2,29,30,31,32)/t16-,17+/m0/s1 HIPKSRSJDXEWDZ-DLBZAZTESA-N 161180 US9682976, 66 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161180 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161180&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 123842308 355042161 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467614 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5C[C@H](F)CN5C(C)(C)C4)n3)c(F)cc2C2CC2)c1=O InChI=1S/C25H30F3N9O/c1-25(2)10-15(7-16-6-14(26)12-36(16)25)30-22-19(28)11-29-23(32-22)31-20-9-21(37-24(38)35(3)33-34-37)17(8-18(20)27)13-4-5-13/h8-9,11,13-16H,4-7,10,12H2,1-3H3,(H2,29,30,31,32)/t14-,15+,16-/m0/s1 CQWAILPSZVCBCM-XHSDSOJGSA-N 161181 US9682976, 67 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161181&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811518 355042162 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467615 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5C[C@@H](O)CN5C(C)(C)C4)n3)c(F)cc2C2CC2)c1=O InChI=1S/C25H31F2N9O2/c1-25(2)10-14(6-15-7-16(37)12-35(15)25)29-22-19(27)11-28-23(31-22)30-20-9-21(36-24(38)34(3)32-33-36)17(8-18(20)26)13-4-5-13/h8-9,11,13-16,37H,4-7,10,12H2,1-3H3,(H2,28,29,30,31)/t14-,15-,16-/m1/s1 RRKBAAMUKUDNPY-BZUAXINKSA-N 161209 US9682976, 68 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161209 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161209&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89855603 355042163 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467616 CC1C2CCCN2C(C)(C)CC1Nc1nc(Nc2cc(c(cc2F)C2CC2)-n2nnn(C)c2=O)ncc1F InChI=1S/C26H33F2N9O/c1-14-20(12-26(2,3)36-9-5-6-21(14)36)30-23-18(28)13-29-24(32-23)31-19-11-22(37-25(38)35(4)33-34-37)16(10-17(19)27)15-7-8-15/h10-11,13-15,20-21H,5-9,12H2,1-4H3,(H2,29,30,31,32) VPYYHGPTUNNIPM-UHFFFAOYSA-N 161210 US9682976, 69 Interleukin-2 <1000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161210&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811520 355042164 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467617 CC1C2CCCN2C(C)(C)CC1Nc1nc(Nc2ccc(F)c(c2)-n2nnnc2C)ncc1F InChI=1S/C23H29F2N9/c1-13-18(11-23(3,4)33-9-5-6-19(13)33)28-21-17(25)12-26-22(29-21)27-15-7-8-16(24)20(10-15)34-14(2)30-31-32-34/h7-8,10,12-13,18-19H,5-6,9,11H2,1-4H3,(H2,26,27,28,29) VWAMICUZLIDILJ-UHFFFAOYSA-N 161211 US9682976, 70 Interleukin-2 <10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161211 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161211&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811519 355042165 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467618 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2cc(ccc2F)S(F)(F)(F)(F)F)ncc1F InChI=1S/C20H24F7N5S/c1-20(2)10-12(8-13-4-3-7-32(13)20)29-18-16(22)11-28-19(31-18)30-17-9-14(5-6-15(17)21)33(23,24,25,26)27/h5-6,9,11-13H,3-4,7-8,10H2,1-2H3,(H2,28,29,30,31)/t12-,13+/m1/s1 ZXRSHFCRUHIWBD-OLZOCXBDSA-N 161214 US9682976, 71 Interleukin-2 <1000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161214 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161214&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89863865 355042166 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467619 CC1(C)C[C@H](C[C@H]2CCCN12)Nc1nc(Nc2cc(ccc2F)S(F)(F)(F)(F)F)ncc1F InChI=1S/C20H24F7N5S/c1-20(2)10-12(8-13-4-3-7-32(13)20)29-18-16(22)11-28-19(31-18)30-17-9-14(5-6-15(17)21)33(23,24,25,26)27/h5-6,9,11-13H,3-4,7-8,10H2,1-2H3,(H2,28,29,30,31)/t12-,13+/m0/s1 ZXRSHFCRUHIWBD-QWHCGFSZSA-N 161390 US9682976, 72 Interleukin-2 <1000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161390&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 132471181 355042167 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467620 CC1C2CCCN2C(C)(C)CC1Nc1nc(Nc2cc(N(C)C(C)=O)c(cc2F)C2CC2)ncc1F InChI=1S/C27H36F2N6O/c1-15-22(13-27(3,4)35-10-6-7-23(15)35)31-25-20(29)14-30-26(33-25)32-21-12-24(34(5)16(2)36)18(11-19(21)28)17-8-9-17/h11-12,14-15,17,22-23H,6-10,13H2,1-5H3,(H2,30,31,32,33) FIXRKEPXXODAMZ-UHFFFAOYSA-N 161391 US9682976, 73 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161391&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 132471182 355042168 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467621 CC1C2CCCN2C(C)(C)CC1Nc1nc(Nc2cc(N(C)C(=O)N(C)C)c(cc2F)C2CC2)ncc1F InChI=1S/C28H39F2N7O/c1-16-22(14-28(2,3)37-11-7-8-23(16)37)32-25-20(30)15-31-26(34-25)33-21-13-24(36(6)27(38)35(4)5)18(12-19(21)29)17-9-10-17/h12-13,15-17,22-23H,7-11,14H2,1-6H3,(H2,31,32,33,34) LCGYGMOJDAOQFU-UHFFFAOYSA-N 161393 US9682976, 74 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161393&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 132471183 355042169 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467622 CC1C2CCCN2C(C)(C)CC1Nc1nc(Nc2cc(OC(F)F)c(cc2F)C2CC2)ncc1F InChI=1S/C25H31F4N5O/c1-13-19(11-25(2,3)34-8-4-5-20(13)34)31-22-17(27)12-30-24(33-22)32-18-10-21(35-23(28)29)15(9-16(18)26)14-6-7-14/h9-10,12-14,19-20,23H,4-8,11H2,1-3H3,(H2,30,31,32,33) ZPJMXTVUJVEVII-UHFFFAOYSA-N 161394 US9682976, 75 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161394&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 132471184 355042170 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467623 CC1C2CCCN2C(C)(C)CC1Nc1nc(Nc2cc(c(cc2F)C2CC2)-n2nnn(C)c2=O)ncc1C#N InChI=1S/C27H33FN10O/c1-15-21(12-27(2,3)37-9-5-6-22(15)37)31-24-17(13-29)14-30-25(33-24)32-20-11-23(38-26(39)36(4)34-35-38)18(10-19(20)28)16-7-8-16/h10-11,14-16,21-22H,5-9,12H2,1-4H3,(H2,30,31,32,33) FOZVRHPUWVWZSM-UHFFFAOYSA-N 161398 US9682976, 76 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161398&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 132471185 355042171 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467624 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2OCCO)c1=O InChI=1S/C24H31F2N9O3/c1-24(2)12-14(9-15-5-4-6-34(15)24)28-21-17(26)13-27-22(30-21)29-18-11-19(35-23(37)33(3)31-32-35)20(10-16(18)25)38-8-7-36/h10-11,13-15,36H,4-9,12H2,1-3H3,(H2,27,28,29,30)/t14-,15+/m1/s1 RSYAOTAOWSFUSI-CABCVRRESA-N 161400 US9682976, 186::US9682976, 221::US9682976, 77 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161400 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161400&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811556 355042172 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467625 Cn1nnn(-c2cc(Nc3ncc(C#N)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2OCCO)c1=O InChI=1S/C25H31FN10O3/c1-25(2)12-16(9-17-5-4-6-35(17)25)29-22-15(13-27)14-28-23(31-22)30-19-11-20(36-24(38)34(3)32-33-36)21(10-18(19)26)39-8-7-37/h10-11,14,16-17,37H,4-9,12H2,1-3H3,(H2,28,29,30,31)/t16-,17+/m1/s1 QDGMABYPHCMXCV-SJORKVTESA-N 161408 US9682976, 78 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161408 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161408&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811557 355042173 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467626 C[C@H](O)COc1cc(F)c(Nc2ncc(C#N)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnn(C)c1=O InChI=1S/C26H33FN10O3/c1-15(38)14-40-22-9-19(27)20(10-21(22)37-25(39)35(4)33-34-37)31-24-29-13-16(12-28)23(32-24)30-17-8-18-6-5-7-36(18)26(2,3)11-17/h9-10,13,15,17-18,38H,5-8,11,14H2,1-4H3,(H2,29,30,31,32)/t15-,17+,18-/m0/s1 IPDNXEBPZBRHFI-JQHSSLGASA-N 161412 US9682976, 79 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161412 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161412&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811558 355042174 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467627 Cn1nnn(-c2cc(Nc3ncc(C#N)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2OCC(C)(C)O)c1=O InChI=1S/C27H35FN10O3/c1-26(2)12-17(9-18-7-6-8-37(18)26)31-23-16(13-29)14-30-24(33-23)32-20-11-21(38-25(39)36(5)34-35-38)22(10-19(20)28)41-15-27(3,4)40/h10-11,14,17-18,40H,6-9,12,15H2,1-5H3,(H2,30,31,32,33)/t17-,18+/m1/s1 PUZBKIAHRGEHKU-MSOLQXFVSA-N 161413 US9682976, 80 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161413 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161413&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811559 355042175 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467628 C[C@H](O)COc1cc(F)c(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnn(C)c1=O InChI=1S/C25H33F2N9O3/c1-14(37)13-39-21-9-17(26)19(10-20(21)36-24(38)34(4)32-33-36)30-23-28-12-18(27)22(31-23)29-15-8-16-6-5-7-35(16)25(2,3)11-15/h9-10,12,14-16,37H,5-8,11,13H2,1-4H3,(H2,28,29,30,31)/t14-,15+,16-/m0/s1 VBVITBNLMMIWGW-XHSDSOJGSA-N 161414 US9682976, 81 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161414 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161414&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811594 355042176 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467629 C[C@@H](O)COc1cc(F)c(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnn(C)c1=O InChI=1S/C25H33F2N9O3/c1-14(37)13-39-21-9-17(26)19(10-20(21)36-24(38)34(4)32-33-36)30-23-28-12-18(27)22(31-23)29-15-8-16-6-5-7-35(16)25(2,3)11-15/h9-10,12,14-16,37H,5-8,11,13H2,1-4H3,(H2,28,29,30,31)/t14-,15-,16+/m1/s1 VBVITBNLMMIWGW-OAGGEKHMSA-N 161417 US9682976, 82 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161417 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161417&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811595 355042177 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467630 Cn1nnn(-c2cc(Nc3ncc(C#N)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)ccc2OC(C)(C)CO)c1=O InChI=1S/C27H36N10O3/c1-26(2)13-19(11-20-7-6-10-36(20)26)30-23-17(14-28)15-29-24(32-23)31-18-8-9-22(40-27(3,4)16-38)21(12-18)37-25(39)35(5)33-34-37/h8-9,12,15,19-20,38H,6-7,10-11,13,16H2,1-5H3,(H2,29,30,31,32)/t19-,20+/m1/s1 QONBDHWAHAIEPO-UXHICEINSA-N 161418 US9682976, 83 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161418&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811596 355042178 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467631 Cn1nnn(-c2cc(Nc3ncc(C#N)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2OC(C)(C)CO)c1=O InChI=1S/C27H35FN10O3/c1-26(2)12-17(9-18-7-6-8-37(18)26)31-23-16(13-29)14-30-24(33-23)32-20-11-21(38-25(40)36(5)34-35-38)22(10-19(20)28)41-27(3,4)15-39/h10-11,14,17-18,39H,6-9,12,15H2,1-5H3,(H2,30,31,32,33)/t17-,18+/m1/s1 JASTXUFYUXVTHZ-MSOLQXFVSA-N 161420 US9682976, 84 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161420 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161420&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811597 355042179 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467632 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2OC(C)(C)CO)c1=O InChI=1S/C26H35F2N9O3/c1-25(2)12-15(9-16-7-6-8-36(16)25)30-22-18(28)13-29-23(32-22)31-19-11-20(37-24(39)35(5)33-34-37)21(10-17(19)27)40-26(3,4)14-38/h10-11,13,15-16,38H,6-9,12,14H2,1-5H3,(H2,29,30,31,32)/t15-,16+/m1/s1 JMRJDKDZDSXAMT-CVEARBPZSA-N 161421 US9682976, 85 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161421 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161421&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811636 355042180 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467633 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)ccc2OC(C)(C)CO)c1=O InChI=1S/C26H36FN9O3/c1-25(2)13-17(11-18-7-6-10-35(18)25)29-22-19(27)14-28-23(31-22)30-16-8-9-21(39-26(3,4)15-37)20(12-16)36-24(38)34(5)32-33-36/h8-9,12,14,17-18,37H,6-7,10-11,13,15H2,1-5H3,(H2,28,29,30,31)/t17-,18+/m1/s1 KMBIGXCDCCXBDY-MSOLQXFVSA-N 161422 US9682976, 86 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161422 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161422&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811637 355042181 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467634 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2OCC(C)(C)O)c1=O InChI=1S/C26H35F2N9O3/c1-25(2)12-15(9-16-7-6-8-36(16)25)30-22-18(28)13-29-23(32-22)31-19-11-20(37-24(38)35(5)33-34-37)21(10-17(19)27)40-14-26(3,4)39/h10-11,13,15-16,39H,6-9,12,14H2,1-5H3,(H2,29,30,31,32)/t15-,16+/m1/s1 JBUOTBFLGXBXHM-CVEARBPZSA-N 161423 US9682976, 87 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161423 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161423&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811638 355042182 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467635 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2OC2COC2)c1=O InChI=1S/C25H31F2N9O3/c1-25(2)10-14(7-15-5-4-6-35(15)25)29-22-18(27)11-28-23(31-22)30-19-9-20(36-24(37)34(3)32-33-36)21(8-17(19)26)39-16-12-38-13-16/h8-9,11,14-16H,4-7,10,12-13H2,1-3H3,(H2,28,29,30,31)/t14-,15+/m1/s1 NPNDELYYKIIXRL-CABCVRRESA-N 161424 US9682976, 88 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161424 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161424&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811728 355042183 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467636 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2O)c1=O InChI=1S/C22H27F2N9O2/c1-22(2)10-12(7-13-5-4-6-32(13)22)26-19-15(24)11-25-20(28-19)27-16-9-17(18(34)8-14(16)23)33-21(35)31(3)29-30-33/h8-9,11-13,34H,4-7,10H2,1-3H3,(H2,25,26,27,28)/t12-,13+/m1/s1 BEBHWQRETFBEGD-OLZOCXBDSA-N 161428 US9682976, 89 Interleukin-2 <10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161428 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161428&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 86275295 355042184 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467637 C[C@@H](O)COc1cc(F)c(Nc2ncc(C#N)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnn(C)c1=O InChI=1S/C26H33FN10O3/c1-15(38)14-40-22-9-19(27)20(10-21(22)37-25(39)35(4)33-34-37)31-24-29-13-16(12-28)23(32-24)30-17-8-18-6-5-7-36(18)26(2,3)11-17/h9-10,13,15,17-18,38H,5-8,11,14H2,1-4H3,(H2,29,30,31,32)/t15-,17-,18+/m1/s1 IPDNXEBPZBRHFI-NXHRZFHOSA-N 161430 US9682976, 314::US9682976, 90 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161430 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161430&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 86275934 355042185 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467638 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2Br)c1=O InChI=1S/C22H26BrF2N9O/c1-22(2)10-12(7-13-5-4-6-33(13)22)27-19-16(25)11-26-20(29-19)28-17-9-18(14(23)8-15(17)24)34-21(35)32(3)30-31-34/h8-9,11-13H,4-7,10H2,1-3H3,(H2,26,27,28,29)/t12-,13+/m1/s1 DIBPQHOPOFDJIP-OLZOCXBDSA-N 161431 US9682976, 91 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161431 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161431&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 86704494 355042186 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467639 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2C=C)c1=O InChI=1S/C24H29F2N9O/c1-5-14-9-17(25)19(11-20(14)35-23(36)33(4)31-32-35)29-22-27-13-18(26)21(30-22)28-15-10-16-7-6-8-34(16)24(2,3)12-15/h5,9,11,13,15-16H,1,6-8,10,12H2,2-4H3,(H2,27,28,29,30)/t15-,16+/m1/s1 NMZYPNYNOCKYOS-CVEARBPZSA-N 161432 US9682976, 92 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161432&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 86704496 355042187 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467640 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2CCO)c1=O InChI=1S/C24H31F2N9O2/c1-24(2)12-15(10-16-5-4-7-34(16)24)28-21-18(26)13-27-22(30-21)29-19-11-20(14(6-8-36)9-17(19)25)35-23(37)33(3)31-32-35/h9,11,13,15-16,36H,4-8,10,12H2,1-3H3,(H2,27,28,29,30)/t15-,16+/m1/s1 PPLQXWLAQKLJMY-CVEARBPZSA-N 161441 US9682976, 93 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161441&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89863661 355042188 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467641 CC(O)c1cc(F)c(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnn(C)c1=O InChI=1S/C24H31F2N9O2/c1-13(36)16-9-17(25)19(10-20(16)35-23(37)33(4)31-32-35)29-22-27-12-18(26)21(30-22)28-14-8-15-6-5-7-34(15)24(2,3)11-14/h9-10,12-15,36H,5-8,11H2,1-4H3,(H2,27,28,29,30)/t13?,14-,15+/m1/s1 VMAOEDCJABWXBK-DMJDIKPUSA-N 161445 US9682976, 94 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161445&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89863871 355042189 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467642 CCc1cc(F)c(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnn(C)c1=O InChI=1S/C24H31F2N9O/c1-5-14-9-17(25)19(11-20(14)35-23(36)33(4)31-32-35)29-22-27-13-18(26)21(30-22)28-15-10-16-7-6-8-34(16)24(2,3)12-15/h9,11,13,15-16H,5-8,10,12H2,1-4H3,(H2,27,28,29,30)/t15-,16+/m1/s1 QLFDTSGRRHTPAW-CVEARBPZSA-N 161454 US9682976, 95 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161454 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161454&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89863744 355042190 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467643 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2C#CCO)c1=O InChI=1S/C25H29F2N9O2/c1-25(2)13-16(11-17-7-4-8-35(17)25)29-22-19(27)14-28-23(31-22)30-20-12-21(36-24(38)34(3)32-33-36)15(6-5-9-37)10-18(20)26/h10,12,14,16-17,37H,4,7-9,11,13H2,1-3H3,(H2,28,29,30,31)/t16-,17+/m1/s1 SNQYVACNZUUNLD-SJORKVTESA-N 161457 US9682976, 96 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161457 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161457&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 86704497 355042191 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467645 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2C#N)c1=O InChI=1S/C23H26F2N10O/c1-23(2)10-14(8-15-5-4-6-34(15)23)28-20-17(25)12-27-21(30-20)29-18-9-19(13(11-26)7-16(18)24)35-22(36)33(3)31-32-35/h7,9,12,14-15H,4-6,8,10H2,1-3H3,(H2,27,28,29,30)/t14-,15+/m1/s1 BELKJKUODGXTKO-CABCVRRESA-N 161459 US9682976, 98 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161459&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 86704499 355042193 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467646 C[C@H](CO)Oc1cc(F)c(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnn(C)c1=O InChI=1S/C25H33F2N9O3/c1-14(13-37)39-21-9-17(26)19(10-20(21)36-24(38)34(4)32-33-36)30-23-28-12-18(27)22(31-23)29-15-8-16-6-5-7-35(16)25(2,3)11-15/h9-10,12,14-16,37H,5-8,11,13H2,1-4H3,(H2,28,29,30,31)/t14-,15-,16+/m1/s1 QIESGLGAMPXIEE-OAGGEKHMSA-N 161474 US9682976, 99 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161474&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89863746 355042194 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467647 CC1(C)CC(C[C@@H]2CCCN12)Nc1nc(Nc2ccc(N3CCC4(COC4)CC3)c(c2)C#N)ncc1F InChI=1S/C28H36FN7O/c1-27(2)14-21(13-22-4-3-9-36(22)27)32-25-23(29)16-31-26(34-25)33-20-5-6-24(19(12-20)15-30)35-10-7-28(8-11-35)17-37-18-28/h5-6,12,16,21-22H,3-4,7-11,13-14,17-18H2,1-2H3,(H2,31,32,33,34)/t21?,22-/m0/s1 XNUYXBDRLBGYMB-KEKNWZKVSA-N 161476 US9682976, 100 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161476 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161476&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89863660 355042195 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467648 CC1(C)CC(C[C@@H]2CCCN12)Nc1nc(Nc2ccc(N3CC4(COC4)C3)c(c2)C#N)ncc1F InChI=1S/C26H32FN7O/c1-25(2)10-19(9-20-4-3-7-34(20)25)30-23-21(27)12-29-24(32-23)31-18-5-6-22(17(8-18)11-28)33-13-26(14-33)15-35-16-26/h5-6,8,12,19-20H,3-4,7,9-10,13-16H2,1-2H3,(H2,29,30,31,32)/t19?,20-/m0/s1 PLWGKVGTFORSAU-ANYOKISRSA-N 161480 US9682976, 101 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161480 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161480&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89864017 355042196 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467649 CC1(C)C[C@H](C[C@H]2CCCN12)Nc1nc(Nc2ccc3OC(C)(C)c4nnnn4-c3c2)ncc1F InChI=1S/C24H30FN9O/c1-23(2)12-15(10-16-6-5-9-33(16)23)27-20-17(25)13-26-22(29-20)28-14-7-8-19-18(11-14)34-21(30-31-32-34)24(3,4)35-19/h7-8,11,13,15-16H,5-6,9-10,12H2,1-4H3,(H2,26,27,28,29)/t15-,16+/m0/s1 WKEZTKWVWOCIOX-JKSUJKDBSA-N 160829 US9682976, 1::US9682976, 102 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=160829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=160829&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89854044 355042095 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467650 CC1(C)CC(C[C@@H]2CCCN12)Nc1nc(Nc2ccc(N3CCN(CC3)S(C)(=O)=O)c(c2)C#N)ncc1F InChI=1S/C26H35FN8O2S/c1-26(2)15-20(14-21-5-4-8-35(21)26)30-24-22(27)17-29-25(32-24)31-19-6-7-23(18(13-19)16-28)33-9-11-34(12-10-33)38(3,36)37/h6-7,13,17,20-21H,4-5,8-12,14-15H2,1-3H3,(H2,29,30,31,32)/t20?,21-/m0/s1 JQTRJMHNEYMEPT-LBAQZLPGSA-N 161539 US9682976, 103 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161539 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161539&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 132471186 355042197 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467651 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc3N(CC4CC4)C(=O)COc3c2)ncc1F InChI=1S/C26H33FN6O2/c1-26(2)12-18(10-19-4-3-9-33(19)26)29-24-20(27)13-28-25(31-24)30-17-7-8-21-22(11-17)35-15-23(34)32(21)14-16-5-6-16/h7-8,11,13,16,18-19H,3-6,9-10,12,14-15H2,1-2H3,(H2,28,29,30,31)/t18-,19+/m1/s1 ABDKEXSOBQDPQG-MOPGFXCFSA-N 161540 US9682976, 104 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161540 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161540&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89863874 355042198 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467652 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc3N(CC4CC4)C(=O)C(C)(C)Oc3c2)ncc1F InChI=1S/C28H37FN6O2/c1-27(2)14-19(12-20-6-5-11-35(20)27)31-24-21(29)15-30-26(33-24)32-18-9-10-22-23(13-18)37-28(3,4)25(36)34(22)16-17-7-8-17/h9-10,13,15,17,19-20H,5-8,11-12,14,16H2,1-4H3,(H2,30,31,32,33)/t19-,20+/m1/s1 RTRRQDZCPKDEKK-UXHICEINSA-N 161541 US9682976, 105 Interleukin-2 <1000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161541 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161541&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89863893 355042199 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467653 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(N3CCOCC3)c(c2)C#N)ncc1F InChI=1S/C25H32FN7O/c1-25(2)14-19(13-20-4-3-7-33(20)25)29-23-21(26)16-28-24(31-23)30-18-5-6-22(17(12-18)15-27)32-8-10-34-11-9-32/h5-6,12,16,19-20H,3-4,7-11,13-14H2,1-2H3,(H2,28,29,30,31)/t19-,20+/m1/s1 CKFZLXIEORWZMB-UXHICEINSA-N 161626 US9682976, 106 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161626&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811727 355042200 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467654 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(N3CCC(O)CC3)c(c2)C#N)ncc1F InChI=1S/C26H34FN7O/c1-26(2)14-19(13-20-4-3-9-34(20)26)30-24-22(27)16-29-25(32-24)31-18-5-6-23(17(12-18)15-28)33-10-7-21(35)8-11-33/h5-6,12,16,19-21,35H,3-4,7-11,13-14H2,1-2H3,(H2,29,30,31,32)/t19-,20+/m1/s1 BNPMCFWBDWYWEA-UXHICEINSA-N 161643 US9682976, 107 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161643 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161643&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811726 355042201 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467655 CN1CCN(CC1)c1ccc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1C#N InChI=1S/C26H35FN8/c1-26(2)15-20(14-21-5-4-8-35(21)26)30-24-22(27)17-29-25(32-24)31-19-6-7-23(18(13-19)16-28)34-11-9-33(3)10-12-34/h6-7,13,17,20-21H,4-5,8-12,14-15H2,1-3H3,(H2,29,30,31,32)/t20-,21+/m1/s1 QRXLQYSKFBGJAA-RTWAWAEBSA-N 161649 US9682976, 108 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161649 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161649&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811686 355042202 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467656 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2OC2CCOC2)c1=O InChI=1S/C26H33F2N9O3/c1-26(2)12-15(9-16-5-4-7-36(16)26)30-23-19(28)13-29-24(32-23)31-20-11-21(37-25(38)35(3)33-34-37)22(10-18(20)27)40-17-6-8-39-14-17/h10-11,13,15-17H,4-9,12,14H2,1-3H3,(H2,29,30,31,32)/t15-,16+,17?/m1/s1 WHKQTJGESNASRF-GARXDOFDSA-N 161650 US9682976, 109::US9682976, 110 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161650 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161650&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89863876 355042203 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467657 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2OC2CCOC2)c1=O InChI=1S/C26H33F2N9O3/c1-26(2)12-15(9-16-5-4-7-36(16)26)30-23-19(28)13-29-24(32-23)31-20-11-21(37-25(38)35(3)33-34-37)22(10-18(20)27)40-17-6-8-39-14-17/h10-11,13,15-17H,4-9,12,14H2,1-3H3,(H2,29,30,31,32)/t15-,16+,17?/m1/s1 WHKQTJGESNASRF-GARXDOFDSA-N 161650 US9682976, 109::US9682976, 110 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161650 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161650&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89863876 355042203 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467658 Cn1nnn(-c2cc(Nc3ncc(C#N)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2OC2CCOC2)c1=O InChI=1S/C27H33FN10O3/c1-27(2)12-17(9-18-5-4-7-37(18)27)31-24-16(13-29)14-30-25(33-24)32-21-11-22(38-26(39)36(3)34-35-38)23(10-20(21)28)41-19-6-8-40-15-19/h10-11,14,17-19H,4-9,12,15H2,1-3H3,(H2,30,31,32,33)/t17-,18+,19?/m1/s1 HLYFKAMVDXPCFW-YTYFACEESA-N 161652 US9682976, 111::US9682976, 112 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161652 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161652&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89863697 355042204 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467659 Cn1nnn(-c2cc(Nc3ncc(C#N)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2OC2CCOC2)c1=O InChI=1S/C27H33FN10O3/c1-27(2)12-17(9-18-5-4-7-37(18)27)31-24-16(13-29)14-30-25(33-24)32-21-11-22(38-26(39)36(3)34-35-38)23(10-20(21)28)41-19-6-8-40-15-19/h10-11,14,17-19H,4-9,12,15H2,1-3H3,(H2,30,31,32,33)/t17-,18+,19?/m1/s1 HLYFKAMVDXPCFW-YTYFACEESA-N 161652 US9682976, 111::US9682976, 112 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161652 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161652&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89863697 355042204 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467660 Cn1nnn(-c2cc(Nc3ncc(C#N)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2OC2COC2)c1=O InChI=1S/C26H31FN10O3/c1-26(2)10-16(7-17-5-4-6-36(17)26)30-23-15(11-28)12-29-24(32-23)31-20-9-21(37-25(38)35(3)33-34-37)22(8-19(20)27)40-18-13-39-14-18/h8-9,12,16-18H,4-7,10,13-14H2,1-3H3,(H2,29,30,31,32)/t16-,17+/m1/s1 MKRIJPOTGYQXJX-SJORKVTESA-N 161654 US9682976, 113 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161654&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89864032 355042205 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467661 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2OC2CCOCC2)c1=O InChI=1S/C27H35F2N9O3/c1-27(2)14-16(11-17-5-4-8-37(17)27)31-24-20(29)15-30-25(33-24)32-21-13-22(38-26(39)36(3)34-35-38)23(12-19(21)28)41-18-6-9-40-10-7-18/h12-13,15-18H,4-11,14H2,1-3H3,(H2,30,31,32,33)/t16-,17+/m1/s1 XPMFITJGZVFVNF-SJORKVTESA-N 161655 US9682976, 114 Interleukin-2 <1000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161655&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89863745 355042206 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467662 Cn1nnn(-c2cc(Nc3ncc(C#N)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2OC2CCOCC2)c1=O InChI=1S/C28H35FN10O3/c1-28(2)14-18(11-19-5-4-8-38(19)28)32-25-17(15-30)16-31-26(34-25)33-22-13-23(39-27(40)37(3)35-36-39)24(12-21(22)29)42-20-6-9-41-10-7-20/h12-13,16,18-20H,4-11,14H2,1-3H3,(H2,31,32,33,34)/t18-,19+/m1/s1 ISPGOYNRJYMHGN-MOPGFXCFSA-N 161656 US9682976, 115 Interleukin-2 <1000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161656 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161656&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89863884 355042207 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467663 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(N3CCN(CC3)C3COC3)c(c2)C#N)ncc1F InChI=1S/C28H37FN8O/c1-28(2)14-21(13-22-4-3-7-37(22)28)32-26-24(29)16-31-27(34-26)33-20-5-6-25(19(12-20)15-30)36-10-8-35(9-11-36)23-17-38-18-23/h5-6,12,16,21-23H,3-4,7-11,13-14,17-18H2,1-2H3,(H2,31,32,33,34)/t21-,22+/m1/s1 VDRXYXJEMPJMRX-YADHBBJMSA-N 161657 US9682976, 116 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161657 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161657&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89863698 355042208 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467664 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)ccc2N2CCN(CC2)C2COC2)c1=O InChI=1S/C29H40FN11O2/c1-29(2)15-20(13-21-5-4-8-40(21)29)32-26-23(30)16-31-27(34-26)33-19-6-7-24(25(14-19)41-28(42)37(3)35-36-41)39-11-9-38(10-12-39)22-17-43-18-22/h6-7,14,16,20-22H,4-5,8-13,15,17-18H2,1-3H3,(H2,31,32,33,34)/t20-,21+/m1/s1 VIUMVNLYLZGPMY-RTWAWAEBSA-N 161658 US9682976, 117 Interleukin-2 <10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161658 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161658&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 86704505 355042209 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467665 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(OC3CCNCC3)c(c2)C(F)(F)F)ncc1F InChI=1S/C26H34F4N6O/c1-25(2)14-17(12-18-4-3-11-36(18)25)33-23-21(27)15-32-24(35-23)34-16-5-6-22(20(13-16)26(28,29)30)37-19-7-9-31-10-8-19/h5-6,13,15,17-19,31H,3-4,7-12,14H2,1-2H3,(H2,32,33,34,35)/t17-,18+/m1/s1 OSABAYROLNNTLM-MSOLQXFVSA-N 161659 US9682976, 118 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161659 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161659&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 86704506 355042210 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467666 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(O[C@@H]3CCNC[C@H]3F)c(c2)C(F)(F)F)ncc1F InChI=1S/C26H33F5N6O/c1-25(2)12-16(10-17-4-3-9-37(17)25)34-23-20(28)14-33-24(36-23)35-15-5-6-21(18(11-15)26(29,30)31)38-22-7-8-32-13-19(22)27/h5-6,11,14,16-17,19,22,32H,3-4,7-10,12-13H2,1-2H3,(H2,33,34,35,36)/t16-,17+,19-,22-/m1/s1 GENCTRCNSUVNAB-ZRAXVTTISA-N 161660 US9682976, 119 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161660 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161660&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89863887 355042211 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467667 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(OC3CCN(CC3)C3COC3)c(c2)C(F)(F)F)ncc1F InChI=1S/C29H38F4N6O2/c1-28(2)14-19(12-20-4-3-9-39(20)28)35-26-24(30)15-34-27(37-26)36-18-5-6-25(23(13-18)29(31,32)33)41-22-7-10-38(11-8-22)21-16-40-17-21/h5-6,13,15,19-22H,3-4,7-12,14,16-17H2,1-2H3,(H2,34,35,36,37)/t19-,20+/m1/s1 BSPJCXJLHIGROG-UXHICEINSA-N 161661 US9682976, 120 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161661 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161661&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811682 355042212 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467668 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(O[C@H]3CCNC[C@@H]3F)c(c2)C(F)(F)F)ncc1F InChI=1S/C26H33F5N6O/c1-25(2)12-16(10-17-4-3-9-37(17)25)34-23-20(28)14-33-24(36-23)35-15-5-6-21(18(11-15)26(29,30)31)38-22-7-8-32-13-19(22)27/h5-6,11,14,16-17,19,22,32H,3-4,7-10,12-13H2,1-2H3,(H2,33,34,35,36)/t16-,17+,19+,22+/m1/s1 GENCTRCNSUVNAB-PPULILFRSA-N 161662 US9682976, 121 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161662 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161662&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811681 355042213 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467669 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(O[C@@H]3CCN(C[C@H]3F)C3COC3)c(c2)C(F)(F)F)ncc1F InChI=1S/C29H37F5N6O2/c1-28(2)12-18(10-19-4-3-8-40(19)28)36-26-22(30)13-35-27(38-26)37-17-5-6-24(21(11-17)29(32,33)34)42-25-7-9-39(14-23(25)31)20-15-41-16-20/h5-6,11,13,18-20,23,25H,3-4,7-10,12,14-16H2,1-2H3,(H2,35,36,37,38)/t18-,19+,23-,25-/m1/s1 NIUSHXNLFDJTKR-AAYSFUBESA-N 161663 US9682976, 122 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161663 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161663&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89863709 355042214 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467670 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(O[C@H]3CCNC[C@@H]3F)c(Cl)c2)ncc1F InChI=1S/C25H33ClF2N6O/c1-25(2)12-16(10-17-4-3-9-34(17)25)31-23-20(28)14-30-24(33-23)32-15-5-6-21(18(26)11-15)35-22-7-8-29-13-19(22)27/h5-6,11,14,16-17,19,22,29H,3-4,7-10,12-13H2,1-2H3,(H2,30,31,32,33)/t16-,17+,19+,22+/m1/s1 WGNNMPNATYJUGM-PPULILFRSA-N 161664 US9682976, 123 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161664 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161664&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 86704518 355042215 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467671 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(OC3CCNCC3O)c(Cl)c2)ncc1F InChI=1S/C25H34ClFN6O2/c1-25(2)12-16(10-17-4-3-9-33(17)25)30-23-19(27)13-29-24(32-23)31-15-5-6-21(18(26)11-15)35-22-7-8-28-14-20(22)34/h5-6,11,13,16-17,20,22,28,34H,3-4,7-10,12,14H2,1-2H3,(H2,29,30,31,32)/t16-,17+,20?,22?/m1/s1 YLVJYBNHEAABJQ-OGQIYBCISA-N 161665 US9682976, 124 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161665&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89863891 355042216 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467672 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc3OC(CO)(CO)c4nnnn4-c3c2)ncc1F InChI=1S/C24H30FN9O3/c1-23(2)10-15(8-16-4-3-7-33(16)23)27-20-17(25)11-26-22(29-20)28-14-5-6-19-18(9-14)34-21(30-31-32-34)24(12-35,13-36)37-19/h5-6,9,11,15-16,35-36H,3-4,7-8,10,12-13H2,1-2H3,(H2,26,27,28,29)/t15-,16+/m1/s1 OVRWFDHZAABHQF-CVEARBPZSA-N 161666 US9682976, 125 Interleukin-2 <10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161666 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161666&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89863895 355042217 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467673 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc3OC4(COC4)c4nnnn4-c3c2)ncc1F InChI=1S/C24H28FN9O2/c1-23(2)10-15(8-16-4-3-7-33(16)23)27-20-17(25)11-26-22(29-20)28-14-5-6-19-18(9-14)34-21(30-31-32-34)24(36-19)12-35-13-24/h5-6,9,11,15-16H,3-4,7-8,10,12-13H2,1-2H3,(H2,26,27,28,29)/t15-,16+/m1/s1 RNLHUGJEXSVYKZ-CVEARBPZSA-N 161667 US9682976, 126 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161667 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161667&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89864081 355042218 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467674 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc3OCC(C)(O)c4nnnn4-c3c2)ncc1F InChI=1S/C24H30FN9O2/c1-23(2)11-15(9-16-5-4-8-33(16)23)27-20-17(25)12-26-22(29-20)28-14-6-7-19-18(10-14)34-21(30-31-32-34)24(3,35)13-36-19/h6-7,10,12,15-16,35H,4-5,8-9,11,13H2,1-3H3,(H2,26,27,28,29)/t15-,16+,24?/m1/s1 KPOLYEQEEKVZHX-XETREBGKSA-N 161668 US9682976, 127 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161668 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161668&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89852582 355042219 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467675 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(OC3CCNCC3)c(OC(F)F)c2)ncc1F InChI=1S/C26H35F3N6O2/c1-26(2)14-17(12-18-4-3-11-35(18)26)32-23-20(27)15-31-25(34-23)33-16-5-6-21(22(13-16)37-24(28)29)36-19-7-9-30-10-8-19/h5-6,13,15,17-19,24,30H,3-4,7-12,14H2,1-2H3,(H2,31,32,33,34)/t17-,18+/m1/s1 VQNIXNJLJHWSHQ-MSOLQXFVSA-N 161669 US9682976, 128 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161669 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161669&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 86704527 355042220 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467676 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(OCCO)c(c2)-n2nnnc2C2CC2)ncc1F InChI=1S/C26H34FN9O2/c1-26(2)14-18(12-19-4-3-9-35(19)26)29-23-20(27)15-28-25(31-23)30-17-7-8-22(38-11-10-37)21(13-17)36-24(16-5-6-16)32-33-34-36/h7-8,13,15-16,18-19,37H,3-6,9-12,14H2,1-2H3,(H2,28,29,30,31)/t18-,19+/m1/s1 FNFXYCZPEYBTFZ-MOPGFXCFSA-N 161670 US9682976, 129 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161670 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161670&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811319 355042221 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467677 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(OCCO)c(F)c2)ncc1F InChI=1S/C22H29F2N5O2/c1-22(2)12-15(10-16-4-3-7-29(16)22)26-20-18(24)13-25-21(28-20)27-14-5-6-19(17(23)11-14)31-9-8-30/h5-6,11,13,15-16,30H,3-4,7-10,12H2,1-2H3,(H2,25,26,27,28)/t15-,16+/m1/s1 ZGONEAOARUJJOU-CVEARBPZSA-N 161671 US9682976, 130 Interleukin-2 <1000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161671&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811318 355042222 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467678 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(OCCO)c(c2)C(F)(F)F)ncc1F InChI=1S/C23H29F4N5O2/c1-22(2)12-15(10-16-4-3-7-32(16)22)29-20-18(24)13-28-21(31-20)30-14-5-6-19(34-9-8-33)17(11-14)23(25,26)27/h5-6,11,13,15-16,33H,3-4,7-10,12H2,1-2H3,(H2,28,29,30,31)/t15-,16+/m1/s1 JGXNSQJJWYRMBO-CVEARBPZSA-N 161672 US9682976, 131 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161672&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811317 355042223 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467679 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)ccc2OCCO)c1=O InChI=1S/C24H32FN9O3/c1-24(2)13-16(11-17-5-4-8-33(17)24)27-21-18(25)14-26-22(29-21)28-15-6-7-20(37-10-9-35)19(12-15)34-23(36)32(3)30-31-34/h6-7,12,14,16-17,35H,4-5,8-11,13H2,1-3H3,(H2,26,27,28,29)/t16-,17+/m1/s1 NIUNOKKILDDXJQ-SJORKVTESA-N 161673 US9682976, 132 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161673&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811316 355042224 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467680 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(OCCO)c(Cl)c2)ncc1F InChI=1S/C22H29ClFN5O2/c1-22(2)12-15(10-16-4-3-7-29(16)22)26-20-18(24)13-25-21(28-20)27-14-5-6-19(17(23)11-14)31-9-8-30/h5-6,11,13,15-16,30H,3-4,7-10,12H2,1-2H3,(H2,25,26,27,28)/t15-,16+/m1/s1 HOYRVZXVOKKECL-CVEARBPZSA-N 161674 US9682976, 133 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161674 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161674&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811286 355042225 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467681 Cc1cc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)ccc1OCCO InChI=1S/C23H32FN5O2/c1-15-11-16(6-7-20(15)31-10-9-30)27-22-25-14-19(24)21(28-22)26-17-12-18-5-4-8-29(18)23(2,3)13-17/h6-7,11,14,17-18,30H,4-5,8-10,12-13H2,1-3H3,(H2,25,26,27,28)/t17-,18+/m1/s1 ONDZJWHTUNKMBW-MSOLQXFVSA-N 161675 US9682976, 134 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161675&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 86704537 355042226 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467682 C[C@@H](CO)Oc1ccc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnn(C)c1=O InChI=1S/C25H34FN9O3/c1-15(14-36)38-21-8-7-16(11-20(21)35-24(37)33(4)31-32-35)29-23-27-13-19(26)22(30-23)28-17-10-18-6-5-9-34(18)25(2,3)12-17/h7-8,11,13,15,17-18,36H,5-6,9-10,12,14H2,1-4H3,(H2,27,28,29,30)/t15-,17+,18-/m0/s1 GPRLCSFNJSNRHF-JQHSSLGASA-N 161676 US9682976, 135 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161676&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811640 355042227 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467683 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc3OC4(CCOCC4)c4nnnn4-c3c2)ncc1F InChI=1S/C26H32FN9O2/c1-25(2)14-17(12-18-4-3-9-35(18)25)29-22-19(27)15-28-24(31-22)30-16-5-6-21-20(13-16)36-23(32-33-34-36)26(38-21)7-10-37-11-8-26/h5-6,13,15,17-18H,3-4,7-12,14H2,1-2H3,(H2,28,29,30,31)/t17-,18+/m1/s1 BQOCFPOOIYMRIQ-MSOLQXFVSA-N 161677 US9682976, 136::US9682976, 137 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161677&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89854924 355042228 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467684 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc3OC4(CCOCC4)c4nnnn4-c3c2)ncc1F InChI=1S/C26H32FN9O2/c1-25(2)14-17(12-18-4-3-9-35(18)25)29-22-19(27)15-28-24(31-22)30-16-5-6-21-20(13-16)36-23(32-33-34-36)26(38-21)7-10-37-11-8-26/h5-6,13,15,17-18H,3-4,7-12,14H2,1-2H3,(H2,28,29,30,31)/t17-,18+/m1/s1 BQOCFPOOIYMRIQ-MSOLQXFVSA-N 161677 US9682976, 136::US9682976, 137 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161677&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89854924 355042228 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467685 CC(C)N1CCN(CC1)c1ccc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1C#N InChI=1S/C28H39FN8/c1-19(2)35-10-12-36(13-11-35)25-8-7-21(14-20(25)17-30)33-27-31-18-24(29)26(34-27)32-22-15-23-6-5-9-37(23)28(3,4)16-22/h7-8,14,18-19,22-23H,5-6,9-13,15-16H2,1-4H3,(H2,31,32,33,34)/t22-,23+/m1/s1 IFRJFBXWXJEMGW-PKTZIBPZSA-N 161679 US9682976, 138 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161679&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 86704540 355042229 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467686 Cn1nnn(-c2cc(Nc3ncc(F)c(n3)N([C@@H]3C[C@@H]4CCCN4C(C)(C)C3)C(C)(C)O)c(F)cc2OC(C)(C)O)c1=O InChI=1S/C28H39F2N9O4/c1-26(2)14-17(11-16-9-8-10-37(16)26)38(27(3,4)41)23-19(30)15-31-24(33-23)32-20-13-21(39-25(40)36(7)34-35-39)22(12-18(20)29)43-28(5,6)42/h12-13,15-17,41-42H,8-11,14H2,1-7H3,(H,31,32,33)/t16-,17+/m0/s1 RSOSVKRMEUCUTO-DLBZAZTESA-N 161680 US9682976, 139 Interleukin-2 >10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161680&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 132471187 355042230 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467687 COc1ccc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnnc1C InChI=1S/C23H30FN9O/c1-14-29-30-31-33(14)19-11-15(7-8-20(19)34-4)27-22-25-13-18(24)21(28-22)26-16-10-17-6-5-9-32(17)23(2,3)12-16/h7-8,11,13,16-17H,5-6,9-10,12H2,1-4H3,(H2,25,26,27,28)/t16-,17+/m1/s1 WGXQEKBKQLCZQR-SJORKVTESA-N 161681 US9682976, 140 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161681&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89853636 355042231 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467688 Cc1nnnn1-c1cc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)ccc1F InChI=1S/C22H27F2N9/c1-13-29-30-31-33(13)19-10-14(6-7-17(19)23)27-21-25-12-18(24)20(28-21)26-15-9-16-5-4-8-32(16)22(2,3)11-15/h6-7,10,12,15-16H,4-5,8-9,11H2,1-3H3,(H2,25,26,27,28)/t15-,16+/m1/s1 LYWIWXMZHZIBTL-CVEARBPZSA-N 161683 US9682976, 141 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161683&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89853588 355042232 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467689 Cc1nnnn1-c1ccc(F)c(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)c1 InChI=1S/C22H27F2N9/c1-13-29-30-31-33(13)16-6-7-17(23)19(10-16)27-21-25-12-18(24)20(28-21)26-14-9-15-5-4-8-32(15)22(2,3)11-14/h6-7,10,12,14-15H,4-5,8-9,11H2,1-3H3,(H2,25,26,27,28)/t14-,15+/m1/s1 AVFRIFZUQLZYIM-CABCVRRESA-N 161684 US9682976, 142 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161684 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161684&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89854087 355042233 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467690 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(F)c(c2)-n2nnnc2C2CC2)ncc1F InChI=1S/C24H29F2N9/c1-24(2)12-16(10-17-4-3-9-34(17)24)28-21-19(26)13-27-23(30-21)29-15-7-8-18(25)20(11-15)35-22(14-5-6-14)31-32-33-35/h7-8,11,13-14,16-17H,3-6,9-10,12H2,1-2H3,(H2,27,28,29,30)/t16-,17+/m1/s1 FRGCSWMHZSRXOH-SJORKVTESA-N 161685 US9682976, 143 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161685 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161685&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89853003 355042234 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467691 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2cc(ccc2F)-n2nnnc2C2CC2)ncc1F InChI=1S/C24H29F2N9/c1-24(2)12-15(10-16-4-3-9-34(16)24)28-21-19(26)13-27-23(30-21)29-20-11-17(7-8-18(20)25)35-22(14-5-6-14)31-32-33-35/h7-8,11,13-16H,3-6,9-10,12H2,1-2H3,(H2,27,28,29,30)/t15-,16+/m1/s1 AFNLLFCNDPBODP-CVEARBPZSA-N 161690 US9682976, 144 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161690&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89854018 355042235 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467692 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(Cl)c(c2)-n2nnnc2C2CC2)ncc1F InChI=1S/C24H29ClFN9/c1-24(2)12-16(10-17-4-3-9-34(17)24)28-21-19(26)13-27-23(30-21)29-15-7-8-18(25)20(11-15)35-22(14-5-6-14)31-32-33-35/h7-8,11,13-14,16-17H,3-6,9-10,12H2,1-2H3,(H2,27,28,29,30)/t16-,17+/m1/s1 QGDQXLUWKVXUOF-SJORKVTESA-N 161691 US9682976, 145 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161691 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161691&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89853726 355042236 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467693 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2cc(c(cc2F)C2CC2)-n2cnnn2)ncc1Cl InChI=1S/C24H29ClFN9/c1-24(2)11-15(8-16-4-3-7-34(16)24)29-22-18(25)12-27-23(31-22)30-20-10-21(35-13-28-32-33-35)17(9-19(20)26)14-5-6-14/h9-10,12-16H,3-8,11H2,1-2H3,(H2,27,29,30,31)/t15-,16+/m1/s1 VMAZZWLUTXZDAF-CVEARBPZSA-N 161692 US9682976, 146 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161692&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89854290 355042237 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467694 Cc1ccc(Nc2ncc(Cl)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1cnnn1 InChI=1S/C22H28ClN9/c1-14-6-7-15(10-19(14)32-13-25-29-30-32)27-21-24-12-18(23)20(28-21)26-16-9-17-5-4-8-31(17)22(2,3)11-16/h6-7,10,12-13,16-17H,4-5,8-9,11H2,1-3H3,(H2,24,26,27,28)/t16-,17+/m1/s1 YEOKQWWKXRQYRB-SJORKVTESA-N 161693 US9682976, 147 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161693&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89854462 355042238 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467695 Cn1nnn(-c2cc(Nc3ncc(Cl)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2C2CC2)c1=O InChI=1S/C25H31ClFN9O/c1-25(2)12-15(9-16-5-4-8-35(16)25)29-22-18(26)13-28-23(31-22)30-20-11-21(36-24(37)34(3)32-33-36)17(10-19(20)27)14-6-7-14/h10-11,13-16H,4-9,12H2,1-3H3,(H2,28,29,30,31)/t15-,16+/m1/s1 FPSFRDVHTGFKDS-CVEARBPZSA-N 161697 US9682976, 148 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161697 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161697&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89863897 355042239 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467696 Cc1nnnn1-c1cc(Nc2ncc(Cl)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)ccc1F InChI=1S/C22H27ClFN9/c1-13-29-30-31-33(13)19-10-14(6-7-18(19)24)27-21-25-12-17(23)20(28-21)26-15-9-16-5-4-8-32(16)22(2,3)11-15/h6-7,10,12,15-16H,4-5,8-9,11H2,1-3H3,(H2,25,26,27,28)/t15-,16+/m1/s1 ZECPCPOIGPGMJI-CVEARBPZSA-N 161698 US9682976, 149 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161698 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161698&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89853379 355042240 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467697 Cc1nnnn1-c1ccc(F)c(Nc2ncc(Cl)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)c1 InChI=1S/C22H27ClFN9/c1-13-29-30-31-33(13)16-6-7-18(24)19(10-16)27-21-25-12-17(23)20(28-21)26-14-9-15-5-4-8-32(15)22(2,3)11-14/h6-7,10,12,14-15H,4-5,8-9,11H2,1-3H3,(H2,25,26,27,28)/t14-,15+/m1/s1 XEBLWMONYRCXLB-CABCVRRESA-N 161699 US9682976, 150 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161699 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161699&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89854505 355042241 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467698 COc1ccc(Nc2ncc(Cl)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnnc1C InChI=1S/C23H30ClN9O/c1-14-29-30-31-33(14)19-11-15(7-8-20(19)34-4)27-22-25-13-18(24)21(28-22)26-16-10-17-6-5-9-32(17)23(2,3)12-16/h7-8,11,13,16-17H,5-6,9-10,12H2,1-4H3,(H2,25,26,27,28)/t16-,17+/m1/s1 WTQAGBDQZUSFOR-SJORKVTESA-N 161700 US9682976, 151 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161700 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161700&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89853715 355042242 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467699 COc1cc(Nc2ncc(Cl)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc(c1)-n1nnnc1C InChI=1S/C23H30ClN9O/c1-14-29-30-31-33(14)18-8-15(10-19(11-18)34-4)27-22-25-13-20(24)21(28-22)26-16-9-17-6-5-7-32(17)23(2,3)12-16/h8,10-11,13,16-17H,5-7,9,12H2,1-4H3,(H2,25,26,27,28)/t16-,17+/m1/s1 OXJYAIYEIGIRJP-SJORKVTESA-N 161701 US9682976, 152 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161701 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161701&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89854648 355042243 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467700 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2cccc(c2)C#N)ncc1Cl InChI=1S/C21H25ClN6/c1-21(2)11-16(10-17-7-4-8-28(17)21)25-19-18(22)13-24-20(27-19)26-15-6-3-5-14(9-15)12-23/h3,5-6,9,13,16-17H,4,7-8,10-11H2,1-2H3,(H2,24,25,26,27)/t16-,17+/m1/s1 NRIZOVPQKMPULJ-SJORKVTESA-N 161702 US9682976, 153 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161702 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161702&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811775 355042244 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467701 Cc1ccc(Nc2ncc(Cl)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1C#N InChI=1S/C22H27ClN6/c1-14-6-7-16(9-15(14)12-24)27-21-25-13-19(23)20(28-21)26-17-10-18-5-4-8-29(18)22(2,3)11-17/h6-7,9,13,17-18H,4-5,8,10-11H2,1-3H3,(H2,25,26,27,28)/t17-,18+/m1/s1 MNJXEDXRUHXILB-MSOLQXFVSA-N 161704 US9682976, 154 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161704 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161704&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89852884 355042245 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467702 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(C3CC3)c(c2)C#N)ncc1Cl InChI=1S/C24H29ClN6/c1-24(2)12-18(11-19-4-3-9-31(19)24)28-22-21(25)14-27-23(30-22)29-17-7-8-20(15-5-6-15)16(10-17)13-26/h7-8,10,14-15,18-19H,3-6,9,11-12H2,1-2H3,(H2,27,28,29,30)/t18-,19+/m1/s1 PZBXTNIBWYOZPO-MOPGFXCFSA-N 161705 US9682976, 155 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161705 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161705&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89852978 355042246 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467703 COc1cc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc(OC)c1OC InChI=1S/C23H32FN5O3/c1-23(2)12-15(9-16-7-6-8-29(16)23)26-21-17(24)13-25-22(28-21)27-14-10-18(30-3)20(32-5)19(11-14)31-4/h10-11,13,15-16H,6-9,12H2,1-5H3,(H2,25,26,27,28)/t15-,16+/m1/s1 METAQSSLDNXOEC-CVEARBPZSA-N 161706 US9682976, 156 Interleukin-2 <10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161706 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161706&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89852687 355042247 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467704 CC1(C)Oc2ccc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)cc2O1 InChI=1S/C23H30FN5O2/c1-22(2)12-15(10-16-6-5-9-29(16)22)26-20-17(24)13-25-21(28-20)27-14-7-8-18-19(11-14)31-23(3,4)30-18/h7-8,11,13,15-16H,5-6,9-10,12H2,1-4H3,(H2,25,26,27,28)/t15-,16+/m1/s1 LSHPMCNEHBDCDX-CVEARBPZSA-N 161707 US9682976, 157 Interleukin-2 <10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161707&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89853405 355042248 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467705 COCCOc1cc(F)c(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnn(C)c1=O InChI=1S/C25H33F2N9O3/c1-25(2)13-15(10-16-6-5-7-35(16)25)29-22-18(27)14-28-23(31-22)30-19-12-20(36-24(37)34(3)32-33-36)21(11-17(19)26)39-9-8-38-4/h11-12,14-16H,5-10,13H2,1-4H3,(H2,28,29,30,31)/t15-,16+/m1/s1 YFDNDTKEMZBVNX-CVEARBPZSA-N 161709 US9682976, 158 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161709 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161709&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 121300642 355042249 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467706 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2OCC2(C)COC2)c1=O InChI=1S/C27H35F2N9O3/c1-26(2)11-16(8-17-6-5-7-37(17)26)31-23-19(29)12-30-24(33-23)32-20-10-21(38-25(39)36(4)34-35-38)22(9-18(20)28)41-15-27(3)13-40-14-27/h9-10,12,16-17H,5-8,11,13-15H2,1-4H3,(H2,30,31,32,33)/t16-,17+/m1/s1 KXZXVBZTQFGGQP-SJORKVTESA-N 161711 US9682976, 159 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161711 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161711&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89853009 355042250 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467707 COCCOc1ccc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)c(F)c1OCCOC InChI=1S/C26H37F2N5O4/c1-26(2)15-17(14-18-6-5-9-33(18)26)30-24-19(27)16-29-25(32-24)31-20-7-8-21(36-12-10-34-3)23(22(20)28)37-13-11-35-4/h7-8,16-18H,5-6,9-15H2,1-4H3,(H2,29,30,31,32)/t17-,18+/m1/s1 QSKWGBJDVVEUTA-MSOLQXFVSA-N 161712 US9682976, 160 Interleukin-2 <10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161712 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161712&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89852638 355042251 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467708 COc1cc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc(OC)c1 InChI=1S/C22H30FN5O2/c1-22(2)12-15(8-16-6-5-7-28(16)22)25-20-19(23)13-24-21(27-20)26-14-9-17(29-3)11-18(10-14)30-4/h9-11,13,15-16H,5-8,12H2,1-4H3,(H2,24,25,26,27)/t15-,16+/m1/s1 QCBZCWVHYBHLTR-CVEARBPZSA-N 161713 US9682976, 161 Interleukin-2 <1000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161713 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161713&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89853150 355042252 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467709 COc1cc(Nc2ncc(Cl)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc(OC)c1 InChI=1S/C22H30ClN5O2/c1-22(2)12-15(8-16-6-5-7-28(16)22)25-20-19(23)13-24-21(27-20)26-14-9-17(29-3)11-18(10-14)30-4/h9-11,13,15-16H,5-8,12H2,1-4H3,(H2,24,25,26,27)/t15-,16+/m1/s1 SYMRBIIUFGGBDM-CVEARBPZSA-N 161714 US9682976, 162 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161714 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161714&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89852445 355042253 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467710 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(F)c(c2)-n2nnnc2C2CC2)ncc1Cl InChI=1S/C24H29ClFN9/c1-24(2)12-16(10-17-4-3-9-34(17)24)28-21-18(25)13-27-23(30-21)29-15-7-8-19(26)20(11-15)35-22(14-5-6-14)31-32-33-35/h7-8,11,13-14,16-17H,3-6,9-10,12H2,1-2H3,(H2,27,28,29,30)/t16-,17+/m1/s1 YLBBPCOUGZGKRF-SJORKVTESA-N 161715 US9682976, 163 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161715 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161715&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89853510 355042254 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467711 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2cc(ccc2F)-n2nnnc2C2CC2)ncc1Cl InChI=1S/C24H29ClFN9/c1-24(2)12-15(10-16-4-3-9-34(16)24)28-21-18(25)13-27-23(30-21)29-20-11-17(7-8-19(20)26)35-22(14-5-6-14)31-32-33-35/h7-8,11,13-16H,3-6,9-10,12H2,1-2H3,(H2,27,28,29,30)/t15-,16+/m1/s1 PSGCGKSRPJISDZ-CVEARBPZSA-N 161716 US9682976, 164 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161716 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161716&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89854186 355042255 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467712 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2OCC2(CO)COC2)c1=O InChI=1S/C27H35F2N9O4/c1-26(2)10-16(7-17-5-4-6-37(17)26)31-23-19(29)11-30-24(33-23)32-20-9-21(38-25(40)36(3)34-35-38)22(8-18(20)28)42-15-27(12-39)13-41-14-27/h8-9,11,16-17,39H,4-7,10,12-15H2,1-3H3,(H2,30,31,32,33)/t16-,17+/m1/s1 GISUCJGROTWPIF-SJORKVTESA-N 161717 US9682976, 165 Interleukin-2 <1000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161717 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161717&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89863753 355042256 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467713 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2OCC2COC2)c1=O InChI=1S/C26H33F2N9O3/c1-26(2)10-16(7-17-5-4-6-36(17)26)30-23-19(28)11-29-24(32-23)31-20-9-21(37-25(38)35(3)33-34-37)22(8-18(20)27)40-14-15-12-39-13-15/h8-9,11,15-17H,4-7,10,12-14H2,1-3H3,(H2,29,30,31,32)/t16-,17+/m1/s1 NGQLXQUPIYIQGA-SJORKVTESA-N 161718 US9682976, 166 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161718 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161718&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89863752 355042257 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467714 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2OCC2CCO2)c1=O InChI=1S/C26H33F2N9O3/c1-26(2)12-15(9-16-5-4-7-36(16)26)30-23-19(28)13-29-24(32-23)31-20-11-21(37-25(38)35(3)33-34-37)22(10-18(20)27)40-14-17-6-8-39-17/h10-11,13,15-17H,4-9,12,14H2,1-3H3,(H2,29,30,31,32)/t15-,16+,17?/m1/s1 SGAWXOINZRUAHZ-GARXDOFDSA-N 161719 US9682976, 167 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161719 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161719&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89863754 355042258 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467715 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(O)c(c2)C#N)ncc1F InChI=1S/C21H25FN6O/c1-21(2)10-15(9-16-4-3-7-28(16)21)25-19-17(22)12-24-20(27-19)26-14-5-6-18(29)13(8-14)11-23/h5-6,8,12,15-16,29H,3-4,7,9-10H2,1-2H3,(H2,24,25,26,27)/t15-,16+/m1/s1 ZAVOAQGMUOUQMD-CVEARBPZSA-N 161720 US9682976, 168 Interleukin-2 <10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161720 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161720&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89852861 355042259 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467716 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2OCC2COCCO2)c1=O InChI=1S/C27H35F2N9O4/c1-27(2)12-16(9-17-5-4-6-37(17)27)31-24-20(29)13-30-25(33-24)32-21-11-22(38-26(39)36(3)34-35-38)23(10-19(21)28)42-15-18-14-40-7-8-41-18/h10-11,13,16-18H,4-9,12,14-15H2,1-3H3,(H2,30,31,32,33)/t16-,17+,18?/m1/s1 IGAANKJZCYFVQM-DVKDBIPTSA-N 161721 US9682976, 169 Interleukin-2 <10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161721 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161721&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89863751 355042260 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467717 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2OCC2CCOCC2)c1=O InChI=1S/C28H37F2N9O3/c1-28(2)14-18(11-19-5-4-8-38(19)28)32-25-21(30)15-31-26(34-25)33-22-13-23(39-27(40)37(3)35-36-39)24(12-20(22)29)42-16-17-6-9-41-10-7-17/h12-13,15,17-19H,4-11,14,16H2,1-3H3,(H2,31,32,33,34)/t18-,19+/m1/s1 HIDRHKGFFJSWEF-MOPGFXCFSA-N 161722 US9682976, 170::US9682976, 187 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161722 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161722&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89853660 355042261 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467718 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2OCC(=O)C(O)=O)c1=O InChI=1S/C25H29F2N9O5/c1-25(2)10-13(7-14-5-4-6-35(14)25)29-21-16(27)11-28-23(31-21)30-17-9-18(36-24(40)34(3)32-33-36)20(8-15(17)26)41-12-19(37)22(38)39/h8-9,11,13-14H,4-7,10,12H2,1-3H3,(H,38,39)(H2,28,29,30,31)/t13-,14+/m1/s1 IAWHWJPTSFYWRO-KGLIPLIRSA-N 161724 US9682976, 171 Interleukin-2 >10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161724 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161724&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89854134 355042262 C00972 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467719 COCCOc1ccc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1C#N InChI=1S/C24H31FN6O2/c1-24(2)13-18(12-19-5-4-8-31(19)24)28-22-20(25)15-27-23(30-22)29-17-6-7-21(16(11-17)14-26)33-10-9-32-3/h6-7,11,15,18-19H,4-5,8-10,12-13H2,1-3H3,(H2,27,28,29,30)/t18-,19+/m1/s1 VJNVZCKXESHMCK-MOPGFXCFSA-N 161725 US9682976, 172 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161725 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161725&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811252 355042263 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467720 CC1(COc2ccc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)cc2C#N)COC1 InChI=1S/C26H33FN6O2/c1-25(2)11-19(10-20-5-4-8-33(20)25)30-23-21(27)13-29-24(32-23)31-18-6-7-22(17(9-18)12-28)35-16-26(3)14-34-15-26/h6-7,9,13,19-20H,4-5,8,10-11,14-16H2,1-3H3,(H2,29,30,31,32)/t19-,20+/m1/s1 HFQAAMHPIHRWSL-UXHICEINSA-N 161726 US9682976, 173 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161726 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161726&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811251 355042264 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467721 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(OCC3(CO)COC3)c(c2)C#N)ncc1F InChI=1S/C26H33FN6O3/c1-25(2)10-19(9-20-4-3-7-33(20)25)30-23-21(27)12-29-24(32-23)31-18-5-6-22(17(8-18)11-28)36-16-26(13-34)14-35-15-26/h5-6,8,12,19-20,34H,3-4,7,9-10,13-16H2,1-2H3,(H2,29,30,31,32)/t19-,20+/m1/s1 AVPWIUXKJZCBQZ-UXHICEINSA-N 161727 US9682976, 174 Interleukin-2 <1000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161727 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161727&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811250 355042265 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467722 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(OCC3COC3)c(c2)C#N)ncc1F InChI=1S/C25H31FN6O2/c1-25(2)10-19(9-20-4-3-7-32(20)25)29-23-21(26)12-28-24(31-23)30-18-5-6-22(17(8-18)11-27)34-15-16-13-33-14-16/h5-6,8,12,16,19-20H,3-4,7,9-10,13-15H2,1-2H3,(H2,28,29,30,31)/t19-,20+/m1/s1 BBZYTNGAOCELNO-UXHICEINSA-N 161728 US9682976, 175 Interleukin-2 <1000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161728 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161728&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811877 355042266 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467723 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(OCC3CCO3)c(c2)C#N)ncc1F InChI=1S/C25H31FN6O2/c1-25(2)12-18(11-19-4-3-8-32(19)25)29-23-21(26)14-28-24(31-23)30-17-5-6-22(16(10-17)13-27)34-15-20-7-9-33-20/h5-6,10,14,18-20H,3-4,7-9,11-12,15H2,1-2H3,(H2,28,29,30,31)/t18-,19+,20?/m1/s1 RBFWJYVUZWEPKC-LFPSWIHMSA-N 161729 US9682976, 176 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161729 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161729&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811876 355042267 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467724 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(OCC3COCCO3)c(c2)C#N)ncc1F InChI=1S/C26H33FN6O3/c1-26(2)12-19(11-20-4-3-7-33(20)26)30-24-22(27)14-29-25(32-24)31-18-5-6-23(17(10-18)13-28)36-16-21-15-34-8-9-35-21/h5-6,10,14,19-21H,3-4,7-9,11-12,15-16H2,1-2H3,(H2,29,30,31,32)/t19-,20+,21?/m1/s1 UVOHNSFOXZUUQH-PDYHCXRVSA-N 161730 US9682976, 177 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161730 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161730&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811875 355042268 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467725 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(OCC3CCOCC3)c(c2)C#N)ncc1F InChI=1S/C27H35FN6O2/c1-27(2)14-21(13-22-4-3-9-34(22)27)31-25-23(28)16-30-26(33-25)32-20-5-6-24(19(12-20)15-29)36-17-18-7-10-35-11-8-18/h5-6,12,16,18,21-22H,3-4,7-11,13-14,17H2,1-2H3,(H2,30,31,32,33)/t21-,22+/m1/s1 BVVVKFNLNDZQMA-YADHBBJMSA-N 161732 US9682976, 178 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161732 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161732&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811874 355042269 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467726 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(OC3COC3)c(c2)C#N)ncc1F InChI=1S/C24H29FN6O2/c1-24(2)10-17(9-18-4-3-7-31(18)24)28-22-20(25)12-27-23(30-22)29-16-5-6-21(15(8-16)11-26)33-19-13-32-14-19/h5-6,8,12,17-19H,3-4,7,9-10,13-14H2,1-2H3,(H2,27,28,29,30)/t17-,18+/m1/s1 HXCAJWLILGGKGO-MSOLQXFVSA-N 161734 US9682976, 179 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161734 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161734&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811873 355042270 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467727 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(Br)c(c2)C#N)ncc1F InChI=1S/C21H24BrFN6/c1-21(2)10-15(9-16-4-3-7-29(16)21)26-19-18(23)12-25-20(28-19)27-14-5-6-17(22)13(8-14)11-24/h5-6,8,12,15-16H,3-4,7,9-10H2,1-2H3,(H2,25,26,27,28)/t15-,16+/m1/s1 GREQTIDRJDGRIH-CVEARBPZSA-N 161735 US9682976, 180 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161735 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161735&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811826 355042271 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467728 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2cc(C#N)c(cc2F)C2CC2)ncc1Cl InChI=1S/C24H28ClFN6/c1-24(2)11-16(9-17-4-3-7-32(17)24)29-22-19(25)13-28-23(31-22)30-21-8-15(12-27)18(10-20(21)26)14-5-6-14/h8,10,13-14,16-17H,3-7,9,11H2,1-2H3,(H2,28,29,30,31)/t16-,17+/m1/s1 AWFGFVKKCHFGFU-SJORKVTESA-N 161736 US9682976, 181 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161736 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161736&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811825 355042272 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467729 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(Cl)c(c2)-n2nnnc2C2CC2)ncc1Cl InChI=1S/C24H29Cl2N9/c1-24(2)12-16(10-17-4-3-9-34(17)24)28-21-19(26)13-27-23(30-21)29-15-7-8-18(25)20(11-15)35-22(14-5-6-14)31-32-33-35/h7-8,11,13-14,16-17H,3-6,9-10,12H2,1-2H3,(H2,27,28,29,30)/t16-,17+/m1/s1 QPRRZKFNCMLJNF-SJORKVTESA-N 161737 US9682976, 182 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161737 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161737&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89853576 355042273 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467730 COc1cc(Nc2ncc(Cl)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc(OC)c1OC InChI=1S/C23H32ClN5O3/c1-23(2)12-15(9-16-7-6-8-29(16)23)26-21-17(24)13-25-22(28-21)27-14-10-18(30-3)20(32-5)19(11-14)31-4/h10-11,13,15-16H,6-9,12H2,1-5H3,(H2,25,26,27,28)/t15-,16+/m1/s1 KYSPUNNHXOKRMC-CVEARBPZSA-N 161738 US9682976, 183 Interleukin-2 <10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161738 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161738&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89852763 355042274 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467731 CCOC(=O)C(C)Oc1cc(F)c(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnn(C)c1=O InChI=1S/C27H35F2N9O4/c1-6-41-24(39)15(2)42-22-11-18(28)20(12-21(22)38-26(40)36(5)34-35-38)32-25-30-14-19(29)23(33-25)31-16-10-17-8-7-9-37(17)27(3,4)13-16/h11-12,14-17H,6-10,13H2,1-5H3,(H2,30,31,32,33)/t15?,16-,17+/m1/s1 CLQDRHZADZJIMD-FGJGXXMFSA-N 161739 US9682976, 184 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161739 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161739&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89854271 355042275 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467732 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2OC2CCOC2=O)c1=O InChI=1S/C26H31F2N9O4/c1-26(2)12-14(9-15-5-4-7-36(15)26)30-22-17(28)13-29-24(32-22)31-18-11-19(37-25(39)35(3)33-34-37)21(10-16(18)27)41-20-6-8-40-23(20)38/h10-11,13-15,20H,4-9,12H2,1-3H3,(H2,29,30,31,32)/t14-,15+,20?/m1/s1 WSEGUELEIBKHRX-FKTKBCEVSA-N 161741 US9682976, 185 Interleukin-2 >10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161741 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161741&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89863928 355042276 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467733 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2OCCO)c1=O InChI=1S/C24H31F2N9O3/c1-24(2)12-14(9-15-5-4-6-34(15)24)28-21-17(26)13-27-22(30-21)29-18-11-19(35-23(37)33(3)31-32-35)20(10-16(18)25)38-8-7-36/h10-11,13-15,36H,4-9,12H2,1-3H3,(H2,27,28,29,30)/t14-,15+/m1/s1 RSYAOTAOWSFUSI-CABCVRRESA-N 161400 US9682976, 186::US9682976, 221::US9682976, 77 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161400 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161400&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811556 355042172 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467734 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2OCC2CCOCC2)c1=O InChI=1S/C28H37F2N9O3/c1-28(2)14-18(11-19-5-4-8-38(19)28)32-25-21(30)15-31-26(34-25)33-22-13-23(39-27(40)37(3)35-36-39)24(12-20(22)29)42-16-17-6-9-41-10-7-17/h12-13,15,17-19H,4-11,14,16H2,1-3H3,(H2,31,32,33,34)/t18-,19+/m1/s1 HIDRHKGFFJSWEF-MOPGFXCFSA-N 161722 US9682976, 170::US9682976, 187 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161722 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161722&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89853660 355042261 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467644 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2CCCO)c1=O InChI=1S/C25H33F2N9O2/c1-25(2)13-16(11-17-7-4-8-35(17)25)29-22-19(27)14-28-23(31-22)30-20-12-21(36-24(38)34(3)32-33-36)15(6-5-9-37)10-18(20)26/h10,12,14,16-17,37H,4-9,11,13H2,1-3H3,(H2,28,29,30,31)/t16-,17+/m1/s1 CVBYXRJFBCJMHS-SJORKVTESA-N 161458 US9682976, 97 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161458&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 86704498 355042192 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467735 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2OC[C@H](O)CO)c1=O InChI=1S/C25H33F2N9O4/c1-25(2)10-14(7-15-5-4-6-35(15)25)29-22-18(27)11-28-23(31-22)30-19-9-20(36-24(39)34(3)32-33-36)21(8-17(19)26)40-13-16(38)12-37/h8-9,11,14-16,37-38H,4-7,10,12-13H2,1-3H3,(H2,28,29,30,31)/t14-,15+,16-/m1/s1 AYKYNMLUJYMTOD-OWCLPIDISA-N 161746 US9682976, 188 Interleukin-2 <1000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161746 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161746&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89863900 355042277 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467736 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(OCCO)c(c2)C#N)ncc1F InChI=1S/C23H29FN6O2/c1-23(2)12-17(11-18-4-3-7-30(18)23)27-21-19(24)14-26-22(29-21)28-16-5-6-20(32-9-8-31)15(10-16)13-25/h5-6,10,14,17-18,31H,3-4,7-9,11-12H2,1-2H3,(H2,26,27,28,29)/t17-,18+/m1/s1 ICJQVSAYHUGWMQ-MSOLQXFVSA-N 161747 BDBM161772::US9682976, 189::US9682976, 219 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161747&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89852677 355042278 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467737 COCCOCCOc1ccc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1C#N InChI=1S/C26H35FN6O3/c1-26(2)15-20(14-21-5-4-8-33(21)26)30-24-22(27)17-29-25(32-24)31-19-6-7-23(18(13-19)16-28)36-12-11-35-10-9-34-3/h6-7,13,17,20-21H,4-5,8-12,14-15H2,1-3H3,(H2,29,30,31,32)/t20-,21+/m1/s1 YAERTUBLVQASEC-RTWAWAEBSA-N 161748 US9682976, 190 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161748&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89852633 355042279 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467738 CC(=O)O[C@@H]1COC(Oc2cc(F)c(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)cc2-n2nnn(C)c2=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O InChI=1S/C33H41F2N9O9/c1-16(45)50-26-15-49-30(28(52-18(3)47)27(26)51-17(2)46)53-25-11-21(34)23(12-24(25)44-32(48)42(6)40-41-44)38-31-36-14-22(35)29(39-31)37-19-10-20-8-7-9-43(20)33(4,5)13-19/h11-12,14,19-20,26-28,30H,7-10,13,15H2,1-6H3,(H2,36,37,38,39)/t19-,20+,26-,27-,28+,30?/m1/s1 QJVCEGFSGBYKFO-OVILTIPLSA-N 161749 US9682976, 191 Interleukin-2 <10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161749&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89855206 355042280 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467739 CN(C)CCOc1cc(F)c(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnn(C)c1=O InChI=1S/C26H36F2N10O2/c1-26(2)14-16(11-17-7-6-8-37(17)26)30-23-19(28)15-29-24(32-23)31-20-13-21(38-25(39)36(5)33-34-38)22(12-18(20)27)40-10-9-35(3)4/h12-13,15-17H,6-11,14H2,1-5H3,(H2,29,30,31,32)/t16-,17+/m1/s1 DBJAVKKLRILSIN-SJORKVTESA-N 161751 US9682976, 192 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161751 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161751&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89853056 355042281 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467740 CN(C)CCOc1cc(F)c(cc1-n1nnn(C)c1=O)N(CCN(C)C)c1ncc(F)c(N[C@@H]2C[C@@H]3CCCN3C(C)(C)C2)n1 InChI=1S/C30H45F2N11O2/c1-30(2)18-20(15-21-9-8-10-42(21)30)34-27-23(32)19-33-28(35-27)41(12-11-38(3)4)24-17-25(43-29(44)40(7)36-37-43)26(16-22(24)31)45-14-13-39(5)6/h16-17,19-21H,8-15,18H2,1-7H3,(H,33,34,35)/t20-,21+/m1/s1 FWIGBRIJOVFIFD-RTWAWAEBSA-N 161753 US9682976, 193 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161753&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811774 355042282 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467741 CCN(CC)CCOc1cc(F)c(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnn(C)c1=O InChI=1S/C28H40F2N10O2/c1-6-38(7-2)11-12-42-24-14-20(29)22(15-23(24)40-27(41)37(5)35-36-40)33-26-31-17-21(30)25(34-26)32-18-13-19-9-8-10-39(19)28(3,4)16-18/h14-15,17-19H,6-13,16H2,1-5H3,(H2,31,32,33,34)/t18-,19+/m1/s1 JPJHGCNSYBGKQJ-MOPGFXCFSA-N 161754 US9682976, 194 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161754 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161754&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89863943 355042283 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467742 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2OCCN2CCOCC2)c1=O InChI=1S/C28H38F2N10O3/c1-28(2)16-18(13-19-5-4-6-39(19)28)32-25-21(30)17-31-26(34-25)33-22-15-23(40-27(41)37(3)35-36-40)24(14-20(22)29)43-12-9-38-7-10-42-11-8-38/h14-15,17-19H,4-13,16H2,1-3H3,(H2,31,32,33,34)/t18-,19+/m1/s1 XEHHETQZLHRHFY-MOPGFXCFSA-N 161757 US9682976, 195 Interleukin-2 <1000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161757 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161757&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89863953 355042284 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467743 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(O)c(c2)-n2cnnn2)ncc1F InChI=1S/C21H26FN9O/c1-21(2)10-14(8-15-4-3-7-30(15)21)25-19-16(22)11-23-20(27-19)26-13-5-6-18(32)17(9-13)31-12-24-28-29-31/h5-6,9,11-12,14-15,32H,3-4,7-8,10H2,1-2H3,(H2,23,25,26,27)/t14-,15+/m1/s1 FEMNSKHMPWTPHC-CABCVRRESA-N 161758 US9682976, 196 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161758 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161758&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89854929 355042285 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467745 COCCOCCOc1cc(F)c(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnn(C)c1=O InChI=1S/C27H37F2N9O4/c1-27(2)15-17(12-18-6-5-7-37(18)27)31-24-20(29)16-30-25(33-24)32-21-14-22(38-26(39)36(3)34-35-38)23(13-19(21)28)42-11-10-41-9-8-40-4/h13-14,16-18H,5-12,15H2,1-4H3,(H2,30,31,32,33)/t17-,18+/m1/s1 URMRVFQNASQIQK-MSOLQXFVSA-N 161760 US9682976, 198 Interleukin-2 <10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161760 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161760&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89863901 355042287 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467746 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2OCC(O)CO)c1=O InChI=1S/C25H33F2N9O4/c1-25(2)10-14(7-15-5-4-6-35(15)25)29-22-18(27)11-28-23(31-22)30-19-9-20(36-24(39)34(3)32-33-36)21(8-17(19)26)40-13-16(38)12-37/h8-9,11,14-16,37-38H,4-7,10,12-13H2,1-3H3,(H2,28,29,30,31)/t14-,15+,16?/m1/s1 AYKYNMLUJYMTOD-YSPPHNQVSA-N 161761 US9682976, 199 Interleukin-2 <1000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161761&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89863906 355042288 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467747 CC(O)COc1cc(F)c(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnn(C)c1=O InChI=1S/C25H33F2N9O3/c1-14(37)13-39-21-9-17(26)19(10-20(21)36-24(38)34(4)32-33-36)30-23-28-12-18(27)22(31-23)29-15-8-16-6-5-7-35(16)25(2,3)11-15/h9-10,12,14-16,37H,5-8,11,13H2,1-4H3,(H2,28,29,30,31)/t14?,15-,16+/m1/s1 VBVITBNLMMIWGW-JAIYHHTPSA-N 161762 US9682976, 200::US9682976, 220 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161762 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161762&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811282 355042289 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467748 CC(O)COc1ccc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1C#N InChI=1S/C24H31FN6O2/c1-15(32)14-33-21-7-6-17(9-16(21)12-26)29-23-27-13-20(25)22(30-23)28-18-10-19-5-4-8-31(19)24(2,3)11-18/h6-7,9,13,15,18-19,32H,4-5,8,10-11,14H2,1-3H3,(H2,27,28,29,30)/t15?,18-,19+/m1/s1 NSRYLKCUATVCMT-FWZRCDJUSA-N 161763 US9682976, 201 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161763 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161763&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89853006 355042290 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467749 COCCOc1ccc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1cnnn1 InChI=1S/C24H32FN9O2/c1-24(2)13-17(11-18-5-4-8-33(18)24)28-22-19(25)14-26-23(30-22)29-16-6-7-21(36-10-9-35-3)20(12-16)34-15-27-31-32-34/h6-7,12,14-15,17-18H,4-5,8-11,13H2,1-3H3,(H2,26,28,29,30)/t17-,18+/m1/s1 ABSLCBMJYOGQPB-MSOLQXFVSA-N 161764 US9682976, 202 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161764 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161764&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89854522 355042291 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467750 CC1(COc2ccc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)cc2-n2cnnn2)COC1 InChI=1S/C26H34FN9O2/c1-25(2)11-18(9-19-5-4-8-35(19)25)30-23-20(27)12-28-24(32-23)31-17-6-7-22(38-15-26(3)13-37-14-26)21(10-17)36-16-29-33-34-36/h6-7,10,12,16,18-19H,4-5,8-9,11,13-15H2,1-3H3,(H2,28,30,31,32)/t18-,19+/m1/s1 ZJFUXKIDMCZPJL-MOPGFXCFSA-N 161765 US9682976, 203 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161765&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89853695 355042292 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467751 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(OCC3(CO)COC3)c(c2)-n2cnnn2)ncc1F InChI=1S/C26H34FN9O3/c1-25(2)10-18(8-19-4-3-7-35(19)25)30-23-20(27)11-28-24(32-23)31-17-5-6-22(21(9-17)36-16-29-33-34-36)39-15-26(12-37)13-38-14-26/h5-6,9,11,16,18-19,37H,3-4,7-8,10,12-15H2,1-2H3,(H2,28,30,31,32)/t18-,19+/m1/s1 IRFNXEAXZDNYGA-MOPGFXCFSA-N 161766 US9682976, 204 Interleukin-2 <1000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161766 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161766&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89853706 355042293 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467752 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(OCCO)c(c2)-n2cnnn2)ncc1F InChI=1S/C23H30FN9O2/c1-23(2)12-16(10-17-4-3-7-32(17)23)27-21-18(24)13-25-22(29-21)28-15-5-6-20(35-9-8-34)19(11-15)33-14-26-30-31-33/h5-6,11,13-14,16-17,34H,3-4,7-10,12H2,1-2H3,(H2,25,27,28,29)/t16-,17+/m1/s1 MCQSXCUZQCQCKC-SJORKVTESA-N 161767 US9682976, 205 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161767 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161767&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89854281 355042294 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467753 CC(O)COc1ccc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1cnnn1 InChI=1S/C24H32FN9O2/c1-15(35)13-36-21-7-6-16(10-20(21)34-14-27-31-32-34)29-23-26-12-19(25)22(30-23)28-17-9-18-5-4-8-33(18)24(2,3)11-17/h6-7,10,12,14-15,17-18,35H,4-5,8-9,11,13H2,1-3H3,(H2,26,28,29,30)/t15?,17-,18+/m1/s1 HRJQIEYESSEMGH-KVJCIMDZSA-N 161768 US9682976, 206 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161768 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161768&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811773 355042295 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467754 COCCOCCOc1ccc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1cnnn1 InChI=1S/C26H36FN9O3/c1-26(2)15-19(13-20-5-4-8-35(20)26)30-24-21(27)16-28-25(32-24)31-18-6-7-23(39-12-11-38-10-9-37-3)22(14-18)36-17-29-33-34-36/h6-7,14,16-17,19-20H,4-5,8-13,15H2,1-3H3,(H2,28,30,31,32)/t19-,20+/m1/s1 NGWWOKPVETWNQA-UXHICEINSA-N 161769 US9682976, 207 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161769 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161769&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811771 355042296 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467755 COc1cc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)ccc1O InChI=1S/C21H28FN5O2/c1-21(2)11-14(9-15-5-4-8-27(15)21)24-19-16(22)12-23-20(26-19)25-13-6-7-17(28)18(10-13)29-3/h6-7,10,12,14-15,28H,4-5,8-9,11H2,1-3H3,(H2,23,24,25,26)/t14-,15+/m1/s1 PYLCVIJJKWPMAD-CABCVRRESA-N 161770 US9682976, 208 Interleukin-2 <10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161770 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161770&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811731 355042297 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467756 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(OCC(O)(C(F)(F)F)C(F)(F)F)c(c2)C#N)ncc1F InChI=1S/C25H27F7N6O2/c1-22(2)10-16(9-17-4-3-7-38(17)22)35-20-18(26)12-34-21(37-20)36-15-5-6-19(14(8-15)11-33)40-13-23(39,24(27,28)29)25(30,31)32/h5-6,8,12,16-17,39H,3-4,7,9-10,13H2,1-2H3,(H2,34,35,36,37)/t16-,17+/m1/s1 NNHWZWYQMZHVDN-SJORKVTESA-N 161771 US9682976, 209 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161771&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89853874 355042298 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467757 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(OCCO)c(c2)C#N)ncc1F InChI=1S/C23H29FN6O2/c1-23(2)12-17(11-18-4-3-7-30(18)23)27-21-19(24)14-26-22(29-21)28-16-5-6-20(32-9-8-31)15(10-16)13-25/h5-6,10,14,17-18,31H,3-4,7-9,11-12H2,1-2H3,(H2,26,27,28,29)/t17-,18+/m1/s1 ICJQVSAYHUGWMQ-MSOLQXFVSA-N 161747 BDBM161772::US9682976, 189::US9682976, 219 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161747&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89852677 355042278 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467758 CC1(C)C[C@@H](C[C@@H]2CCCN12)N(CC(O)CO)c1nc(Nc2ccc(OCC(O)CO)c(c2)C#N)ncc1F InChI=1S/C27H37FN6O5/c1-27(2)10-20(9-19-4-3-7-34(19)27)33(13-21(37)14-35)25-23(28)12-30-26(32-25)31-18-5-6-24(17(8-18)11-29)39-16-22(38)15-36/h5-6,8,12,19-22,35-38H,3-4,7,9-10,13-16H2,1-2H3,(H,30,31,32)/t19-,20+,21?,22?/m0/s1 CFZKOMYDWQHBLK-QINBWVTOSA-N 161773 US9682976, 211 Interleukin-2 <10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161773&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89853276 355042300 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467759 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(OCC(O)CO)c(c2)C#N)ncc1F InChI=1S/C24H31FN6O3/c1-24(2)10-17(9-18-4-3-7-31(18)24)28-22-20(25)12-27-23(30-22)29-16-5-6-21(15(8-16)11-26)34-14-19(33)13-32/h5-6,8,12,17-19,32-33H,3-4,7,9-10,13-14H2,1-2H3,(H2,27,28,29,30)/t17-,18+,19?/m1/s1 SBLWIAGIZGVPQB-YTYFACEESA-N 161774 US9682976, 212 Interleukin-2 <10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161774 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161774&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89853217 355042301 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467760 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(OCCCO)c(c2)C#N)ncc1F InChI=1S/C24H31FN6O2/c1-24(2)13-18(12-19-5-3-8-31(19)24)28-22-20(25)15-27-23(30-22)29-17-6-7-21(16(11-17)14-26)33-10-4-9-32/h6-7,11,15,18-19,32H,3-5,8-10,12-13H2,1-2H3,(H2,27,28,29,30)/t18-,19+/m1/s1 YNCLNQFBHKIYPL-MOPGFXCFSA-N 161775 US9682976, 213 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161775 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161775&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89853460 355042302 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467761 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(OCC(O)CO)c(c2)-n2cnnn2)ncc1F InChI=1S/C24H32FN9O3/c1-24(2)10-16(8-17-4-3-7-33(17)24)28-22-19(25)11-26-23(30-22)29-15-5-6-21(37-13-18(36)12-35)20(9-15)34-14-27-31-32-34/h5-6,9,11,14,16-18,35-36H,3-4,7-8,10,12-13H2,1-2H3,(H2,26,28,29,30)/t16-,17+,18?/m1/s1 ITDLXRDXBJEYDM-DVKDBIPTSA-N 161776 US9682976, 214 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161776 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161776&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89853194 355042303 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467762 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(OCCCO)c(c2)-n2cnnn2)ncc1F InChI=1S/C24H32FN9O2/c1-24(2)13-17(11-18-5-3-8-33(18)24)28-22-19(25)14-26-23(30-22)29-16-6-7-21(36-10-4-9-35)20(12-16)34-15-27-31-32-34/h6-7,12,14-15,17-18,35H,3-5,8-11,13H2,1-2H3,(H2,26,28,29,30)/t17-,18+/m1/s1 PWDDRWHQJQYYAK-MSOLQXFVSA-N 161777 US9682976, 215::US9682976, 218::US9682976, 224 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161777 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161777&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811284 355042304 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467763 COc1cc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)ccc1OCCO InChI=1S/C23H32FN5O3/c1-23(2)13-16(11-17-5-4-8-29(17)23)26-21-18(24)14-25-22(28-21)27-15-6-7-19(32-10-9-30)20(12-15)31-3/h6-7,12,14,16-17,30H,4-5,8-11,13H2,1-3H3,(H2,25,26,27,28)/t16-,17+/m1/s1 XMMPEYGIVYNXBJ-SJORKVTESA-N 161778 US9682976, 216::US9682976, 217 Interleukin-2 >10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161778 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161778&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811285 355042305 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467764 COc1cc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)ccc1OCCO InChI=1S/C23H32FN5O3/c1-23(2)13-16(11-17-5-4-8-29(17)23)26-21-18(24)14-25-22(28-21)27-15-6-7-19(32-10-9-30)20(12-15)31-3/h6-7,12,14,16-17,30H,4-5,8-11,13H2,1-3H3,(H2,25,26,27,28)/t16-,17+/m1/s1 XMMPEYGIVYNXBJ-SJORKVTESA-N 161778 US9682976, 216::US9682976, 217 Interleukin-2 >10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161778 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161778&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811285 355042305 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467765 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(OCCCO)c(c2)-n2cnnn2)ncc1F InChI=1S/C24H32FN9O2/c1-24(2)13-17(11-18-5-3-8-33(18)24)28-22-19(25)14-26-23(30-22)29-16-6-7-21(36-10-4-9-35)20(12-16)34-15-27-31-32-34/h6-7,12,14-15,17-18,35H,3-5,8-11,13H2,1-2H3,(H2,26,28,29,30)/t17-,18+/m1/s1 PWDDRWHQJQYYAK-MSOLQXFVSA-N 161777 US9682976, 215::US9682976, 218::US9682976, 224 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161777 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161777&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811284 355042304 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467766 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(OCCO)c(c2)C#N)ncc1F InChI=1S/C23H29FN6O2/c1-23(2)12-17(11-18-4-3-7-30(18)23)27-21-19(24)14-26-22(29-21)28-16-5-6-20(32-9-8-31)15(10-16)13-25/h5-6,10,14,17-18,31H,3-4,7-9,11-12H2,1-2H3,(H2,26,27,28,29)/t17-,18+/m1/s1 ICJQVSAYHUGWMQ-MSOLQXFVSA-N 161747 BDBM161772::US9682976, 189::US9682976, 219 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161747&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89852677 355042278 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467767 CC(O)COc1cc(F)c(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnn(C)c1=O InChI=1S/C25H33F2N9O3/c1-14(37)13-39-21-9-17(26)19(10-20(21)36-24(38)34(4)32-33-36)30-23-28-12-18(27)22(31-23)29-15-8-16-6-5-7-35(16)25(2,3)11-15/h9-10,12,14-16,37H,5-8,11,13H2,1-4H3,(H2,28,29,30,31)/t14?,15-,16+/m1/s1 VBVITBNLMMIWGW-JAIYHHTPSA-N 161762 US9682976, 200::US9682976, 220 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161762 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161762&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811282 355042289 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467768 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2OCCO)c1=O InChI=1S/C24H31F2N9O3/c1-24(2)12-14(9-15-5-4-6-34(15)24)28-21-17(26)13-27-22(30-21)29-18-11-19(35-23(37)33(3)31-32-35)20(10-16(18)25)38-8-7-36/h10-11,13-15,36H,4-9,12H2,1-3H3,(H2,27,28,29,30)/t14-,15+/m1/s1 RSYAOTAOWSFUSI-CABCVRRESA-N 161400 US9682976, 186::US9682976, 221::US9682976, 77 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161400 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161400&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811556 355042172 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467769 C[C@H](CO)COc1cc(F)c(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnn(C)c1=O InChI=1S/C26H35F2N9O3/c1-15(13-38)14-40-22-9-18(27)20(10-21(22)37-25(39)35(4)33-34-37)31-24-29-12-19(28)23(32-24)30-16-8-17-6-5-7-36(17)26(2,3)11-16/h9-10,12,15-17,38H,5-8,11,13-14H2,1-4H3,(H2,29,30,31,32)/t15-,16-,17+/m1/s1 DMNOXFBJPGWPLO-ZACQAIPSSA-N 161784 US9682976, 222 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161784 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161784&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811254 355042306 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467770 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(OCCO)c(c2)-n2cnnn2)ncc1Cl InChI=1S/C23H30ClN9O2/c1-23(2)12-16(10-17-4-3-7-32(17)23)27-21-18(24)13-25-22(29-21)28-15-5-6-20(35-9-8-34)19(11-15)33-14-26-30-31-33/h5-6,11,13-14,16-17,34H,3-4,7-10,12H2,1-2H3,(H2,25,27,28,29)/t16-,17+/m1/s1 VQLNPCVENYOMSA-SJORKVTESA-N 161785 US9682976, 223 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161785 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161785&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811253 355042307 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467771 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(OCCCO)c(c2)-n2cnnn2)ncc1F InChI=1S/C24H32FN9O2/c1-24(2)13-17(11-18-5-3-8-33(18)24)28-22-19(25)14-26-23(30-22)29-16-6-7-21(36-10-4-9-35)20(12-16)34-15-27-31-32-34/h6-7,12,14-15,17-18,35H,3-5,8-11,13H2,1-2H3,(H2,26,28,29,30)/t17-,18+/m1/s1 PWDDRWHQJQYYAK-MSOLQXFVSA-N 161777 US9682976, 215::US9682976, 218::US9682976, 224 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161777 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161777&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811284 355042304 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467772 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2OC2CC(C2)OCc2ccccc2)c1=O InChI=1S/C33H39F2N9O3/c1-33(2)17-21(12-22-10-7-11-43(22)33)37-30-26(35)18-36-31(39-30)38-27-16-28(44-32(45)42(3)40-41-44)29(15-25(27)34)47-24-13-23(14-24)46-19-20-8-5-4-6-9-20/h4-6,8-9,15-16,18,21-24H,7,10-14,17,19H2,1-3H3,(H2,36,37,38,39)/t21-,22+,23?,24?/m1/s1 BDJKZYQBQLSRML-CZKGODDJSA-N 161787 US9682976, 225 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161787&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89852592 355042308 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467773 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2OCCNC(=O)OC(C)(C)C)c1=O InChI=1S/C29H40F2N10O4/c1-28(2,3)45-26(42)32-9-11-44-23-13-19(30)21(14-22(23)41-27(43)39(6)37-38-41)35-25-33-16-20(31)24(36-25)34-17-12-18-8-7-10-40(18)29(4,5)15-17/h13-14,16-18H,7-12,15H2,1-6H3,(H,32,42)(H2,33,34,35,36)/t17-,18+/m1/s1 QJOBZOIXNNDFAW-MSOLQXFVSA-N 161788 US9682976, 226 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161788&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89863755 355042309 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467774 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2OC2CC(O)C2)c1=O InChI=1S/C26H33F2N9O3/c1-26(2)12-14(7-15-5-4-6-36(15)26)30-23-19(28)13-29-24(32-23)31-20-11-21(37-25(39)35(3)33-34-37)22(10-18(20)27)40-17-8-16(38)9-17/h10-11,13-17,38H,4-9,12H2,1-3H3,(H2,29,30,31,32)/t14-,15+,16?,17?/m1/s1 XDMBZOIYMOYKSK-XNIRIUNOSA-N 161789 US9682976, 227 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161789&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89863907 355042310 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467775 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2OCCN)c1=O InChI=1S/C24H32F2N10O2/c1-24(2)12-14(9-15-5-4-7-35(15)24)29-21-17(26)13-28-22(31-21)30-18-11-19(36-23(37)34(3)32-33-36)20(10-16(18)25)38-8-6-27/h10-11,13-15H,4-9,12,27H2,1-3H3,(H2,28,29,30,31)/t14-,15+/m1/s1 MRJRFBFEOKPCKB-CABCVRRESA-N 161790 US9682976, 228::US9682976, 231 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161790&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89853538 355042311 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467776 CC(O)COc1ccc(Nc2ncc(Cl)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1C#N InChI=1S/C24H31ClN6O2/c1-15(32)14-33-21-7-6-17(9-16(21)12-26)29-23-27-13-20(25)22(30-23)28-18-10-19-5-4-8-31(19)24(2,3)11-18/h6-7,9,13,15,18-19,32H,4-5,8,10-11,14H2,1-3H3,(H2,27,28,29,30)/t15?,18-,19+/m1/s1 QMQZDDGVFSWTCT-FWZRCDJUSA-N 161791 US9682976, 229 Interleukin-2 <10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161791&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811730 355042312 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467777 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2OCC(O)C(F)(F)F)c1=O InChI=1S/C25H30F5N9O3/c1-24(2)10-13(7-14-5-4-6-38(14)24)32-21-16(27)11-31-22(34-21)33-17-9-18(39-23(41)37(3)35-36-39)19(8-15(17)26)42-12-20(40)25(28,29)30/h8-9,11,13-14,20,40H,4-7,10,12H2,1-3H3,(H2,31,32,33,34)/t13-,14+,20?/m1/s1 DSJDTYYVDJDUBW-NTCUHZHNSA-N 161792 US9682976, 230 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161792&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89864043 355042313 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467778 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2OCCN)c1=O InChI=1S/C24H32F2N10O2/c1-24(2)12-14(9-15-5-4-7-35(15)24)29-21-17(26)13-28-22(31-21)30-18-11-19(36-23(37)34(3)32-33-36)20(10-16(18)25)38-8-6-27/h10-11,13-15H,4-9,12,27H2,1-3H3,(H2,28,29,30,31)/t14-,15+/m1/s1 MRJRFBFEOKPCKB-CABCVRRESA-N 161790 US9682976, 228::US9682976, 231 Interleukin-2 <1000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161790&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89853538 355042311 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467779 Cn1nnn(-c2cc(Nc3ncc(Cl)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2O)c1=O InChI=1S/C22H27ClFN9O2/c1-22(2)10-12(7-13-5-4-6-32(13)22)26-19-14(23)11-25-20(28-19)27-16-9-17(18(34)8-15(16)24)33-21(35)31(3)29-30-33/h8-9,11-13,34H,4-7,10H2,1-3H3,(H2,25,26,27,28)/t12-,13+/m1/s1 MRPPCAXBPQTACM-OLZOCXBDSA-N 161794 US9682976, 232 Interleukin-2 <1000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161794&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89864145 355042314 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467780 CO[C@@H](C)COc1cc(F)c(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnn(C)c1=O InChI=1S/C26H35F2N9O3/c1-15(39-5)14-40-22-10-18(27)20(11-21(22)37-25(38)35(4)33-34-37)31-24-29-13-19(28)23(32-24)30-16-9-17-7-6-8-36(17)26(2,3)12-16/h10-11,13,15-17H,6-9,12,14H2,1-5H3,(H2,29,30,31,32)/t15-,16+,17-/m0/s1 XQXKNFTVHWDBBI-BBWFWOEESA-N 161795 US9682976, 233 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161795&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89863955 355042315 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467781 CO[C@@H](C)COc1cc(F)c(Nc2ncc(F)c(n2)N(C[C@H](C)OC)[C@@H]2C[C@@H]3CCCN3C(C)(C)C2)cc1-n1nnn(C)c1=O InChI=1S/C30H43F2N9O4/c1-18(43-6)16-39(21-11-20-9-8-10-40(20)30(3,4)14-21)27-23(32)15-33-28(35-27)34-24-13-25(41-29(42)38(5)36-37-41)26(12-22(24)31)45-17-19(2)44-7/h12-13,15,18-21H,8-11,14,16-17H2,1-7H3,(H,33,34,35)/t18-,19-,20-,21+/m0/s1 LYYATXZXPCWOKX-XSDIEEQYSA-N 161796 US9682976, 234 Interleukin-2 >10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161796&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89853359 355042316 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467782 C[C@H](O)COc1cc(F)c(Nc2ncc(Cl)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnn(C)c1=O InChI=1S/C25H33ClFN9O3/c1-14(37)13-39-21-9-18(27)19(10-20(21)36-24(38)34(4)32-33-36)30-23-28-12-17(26)22(31-23)29-15-8-16-6-5-7-35(16)25(2,3)11-15/h9-10,12,14-16,37H,5-8,11,13H2,1-4H3,(H2,28,29,30,31)/t14-,15+,16-/m0/s1 HTSLJDMDEMNGEP-XHSDSOJGSA-N 161797 US9682976, 235 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161797&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89864045 355042317 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467783 CC(O)COc1cc(F)c(Nc2ncc(Cl)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnn(C)c1=O InChI=1S/C25H33ClFN9O3/c1-14(37)13-39-21-9-18(27)19(10-20(21)36-24(38)34(4)32-33-36)30-23-28-12-17(26)22(31-23)29-15-8-16-6-5-7-35(16)25(2,3)11-15/h9-10,12,14-16,37H,5-8,11,13H2,1-4H3,(H2,28,29,30,31)/t14?,15-,16+/m1/s1 HTSLJDMDEMNGEP-JAIYHHTPSA-N 161798 US9682976, 236 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161798&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89864140 355042318 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467784 Cn1nnn(-c2cc(Nc3ncc(Cl)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2OCCO)c1=O InChI=1S/C24H31ClFN9O3/c1-24(2)12-14(9-15-5-4-6-34(15)24)28-21-16(25)13-27-22(30-21)29-18-11-19(35-23(37)33(3)31-32-35)20(10-17(18)26)38-8-7-36/h10-11,13-15,36H,4-9,12H2,1-3H3,(H2,27,28,29,30)/t14-,15+/m1/s1 AWBHALPAYVXPAL-CABCVRRESA-N 161799 US9682976, 237 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161799&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89864054 355042319 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467785 CO[C@@H](C)COc1cc(F)c(Nc2ncc(Cl)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnn(C)c1=O InChI=1S/C26H35ClFN9O3/c1-15(39-5)14-40-22-10-19(28)20(11-21(22)37-25(38)35(4)33-34-37)31-24-29-13-18(27)23(32-24)30-16-9-17-7-6-8-36(17)26(2,3)12-16/h10-11,13,15-17H,6-9,12,14H2,1-5H3,(H2,29,30,31,32)/t15-,16+,17-/m0/s1 UXXQMRDQKHHTEK-BBWFWOEESA-N 161800 US9682976, 238 Interleukin-2 <1000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161800&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89863915 355042320 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467786 CO[C@@H](C)COc1cc(F)c(Nc2cc(N(C[C@H](C)OC)[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)c(Cl)cn2)cc1-n1nnn(C)c1=O InChI=1S/C31H44ClFN8O4/c1-19(43-6)17-39(22-11-21-9-8-10-40(21)31(3,4)15-22)26-14-29(34-16-23(26)32)35-25-13-27(41-30(42)38(5)36-37-41)28(12-24(25)33)45-18-20(2)44-7/h12-14,16,19-22H,8-11,15,17-18H2,1-7H3,(H,34,35)/t19-,20-,21-,22+/m0/s1 ROTCOWOZJWYDLT-MYGLTJDJSA-N 161801 US9682976, 239 Interleukin-2 >10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161801&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 132471189 355042321 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467787 Cn1nnn(-c2cc(Nc3ncc(Cl)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2OCC(C)(C)O)c1=O InChI=1S/C26H35ClFN9O3/c1-25(2)12-15(9-16-7-6-8-36(16)25)30-22-17(27)13-29-23(32-22)31-19-11-20(37-24(38)35(5)33-34-37)21(10-18(19)28)40-14-26(3,4)39/h10-11,13,15-16,39H,6-9,12,14H2,1-5H3,(H2,29,30,31,32)/t15-,16+/m1/s1 DHXBBYDGQZQXKU-CVEARBPZSA-N 168227 US9682976, 240 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168227 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168227&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89852588 363891301 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467788 COc1cc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)c(F)c(c1)-n1nnnc1C InChI=1S/C23H29F2N9O/c1-13-30-31-32-34(13)19-10-16(35-4)9-18(20(19)25)28-22-26-12-17(24)21(29-22)27-14-8-15-6-5-7-33(15)23(2,3)11-14/h9-10,12,14-15H,5-8,11H2,1-4H3,(H2,26,27,28,29)/t14-,15+/m1/s1 OYGSHDQOXXNZJL-CABCVRRESA-N 161804 US9682976, 241 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161804 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161804&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89854857 355042322 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467789 COc1cc(cc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)c1F)-n1nnnc1C InChI=1S/C23H29F2N9O/c1-13-30-31-32-34(13)16-9-18(20(25)19(10-16)35-4)28-22-26-12-17(24)21(29-22)27-14-8-15-6-5-7-33(15)23(2,3)11-14/h9-10,12,14-15H,5-8,11H2,1-4H3,(H2,26,27,28,29)/t14-,15+/m1/s1 ISCXKFXOPIJVFT-CABCVRRESA-N 161805 US9682976, 242 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161805 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161805&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89854380 355042323 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467790 COc1cc(c(F)c(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)c1F)-n1nnnc1C InChI=1S/C23H28F3N9O/c1-12-31-32-33-35(12)16-9-17(36-4)19(26)20(18(16)25)29-22-27-11-15(24)21(30-22)28-13-8-14-6-5-7-34(14)23(2,3)10-13/h9,11,13-14H,5-8,10H2,1-4H3,(H2,27,28,29,30)/t13-,14+/m1/s1 RHLVUQXMRHZMBF-KGLIPLIRSA-N 161806 US9682976, 243 Interleukin-2 <1000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161806 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161806&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89853683 355042324 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467791 Cn1nc2n(-c3cc(Nc4ncc(F)c(N[C@@H]5C[C@@H]6CCCN6C(C)(C)C5)n4)ccc3OC2(C)C)c1=O InChI=1S/C26H33FN8O2/c1-25(2)13-16(11-17-7-6-10-34(17)25)29-21-18(27)14-28-23(31-21)30-15-8-9-20-19(12-15)35-22(26(3,4)37-20)32-33(5)24(35)36/h8-9,12,14,16-17H,6-7,10-11,13H2,1-5H3,(H2,28,29,30,31)/t16-,17+/m1/s1 HEFZBQAVPSLFMX-SJORKVTESA-N 161807 US9682976, 248 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161807&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89855224 355042325 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467792 Cc1nnnn1-c1cc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)c(F)cc1OC1COC1 InChI=1S/C25H31F2N9O2/c1-14-32-33-34-36(14)21-9-20(18(26)8-22(21)38-17-12-37-13-17)30-24-28-11-19(27)23(31-24)29-15-7-16-5-4-6-35(16)25(2,3)10-15/h8-9,11,15-17H,4-7,10,12-13H2,1-3H3,(H2,28,29,30,31)/t15-,16+/m1/s1 RWGKCGWOYIOHLQ-CVEARBPZSA-N 161808 US9682976, 249 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161808 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161808&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89854399 355042326 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467793 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc3OC(C)(C)c4nn(C(CO)CCl)c(=O)n4-c3c2)ncc1F InChI=1S/C28H36ClFN8O3/c1-27(2)12-17(10-18-6-5-9-36(18)27)32-23-20(30)14-31-25(34-23)33-16-7-8-22-21(11-16)37-24(28(3,4)41-22)35-38(26(37)40)19(13-29)15-39/h7-8,11,14,17-19,39H,5-6,9-10,12-13,15H2,1-4H3,(H2,31,32,33,34)/t17-,18+,19?/m1/s1 ZWKZWDGMMPLWLU-YTYFACEESA-N 161809 US9682976, 250 Interleukin-2 <10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161809&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 132471190 355042327 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467794 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc3OC(C)(C)c4nn(C5COC5)c(=O)n4-c3c2)ncc1F InChI=1S/C28H35FN8O3/c1-27(2)12-17(10-18-6-5-9-35(18)27)31-23-20(29)13-30-25(33-23)32-16-7-8-22-21(11-16)36-24(28(3,4)40-22)34-37(26(36)38)19-14-39-15-19/h7-8,11,13,17-19H,5-6,9-10,12,14-15H2,1-4H3,(H2,30,31,32,33)/t17-,18+/m1/s1 OEFVGFJTQXTRPX-MSOLQXFVSA-N 161810 US9682976, 251 Interleukin-2 <10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161810 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161810&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89854891 355042328 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467795 Cc1nnnn1-c1cc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)c(F)cc1O InChI=1S/C22H27F2N9O/c1-12-29-30-31-33(12)18-9-17(15(23)8-19(18)34)27-21-25-11-16(24)20(28-21)26-13-7-14-5-4-6-32(14)22(2,3)10-13/h8-9,11,13-14,34H,4-7,10H2,1-3H3,(H2,25,26,27,28)/t13-,14+/m1/s1 QLYWBQDSYLGAOY-KGLIPLIRSA-N 161811 US9682976, 252 Interleukin-2 <10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161811&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89853723 355042329 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467796 CNc1nc2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2o1 InChI=1S/C22H27F2N7O/c1-22(2)10-12(7-13-5-4-6-31(13)22)27-19-15(24)11-26-20(30-19)28-16-9-17-18(8-14(16)23)32-21(25-3)29-17/h8-9,11-13H,4-7,10H2,1-3H3,(H,25,29)(H2,26,27,28,30)/t12-,13+/m1/s1 JKWWNCXYPDZBEU-OLZOCXBDSA-N 161815 US9682976, 253::US9682976, 254 Interleukin-2 <10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161815 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161815&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89853020 355042330 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467797 CNc1nc2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2o1 InChI=1S/C22H27F2N7O/c1-22(2)10-12(7-13-5-4-6-31(13)22)27-19-15(24)11-26-20(30-19)28-16-9-17-18(8-14(16)23)32-21(25-3)29-17/h8-9,11-13H,4-7,10H2,1-3H3,(H,25,29)(H2,26,27,28,30)/t12-,13+/m1/s1 JKWWNCXYPDZBEU-OLZOCXBDSA-N 161815 US9682976, 253::US9682976, 254 Interleukin-2 <10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161815 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161815&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89853020 355042330 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467798 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2cc(c(OC3COC3)cc2F)-n2nnnc2C2CC2)ncc1F InChI=1S/C27H33F2N9O2/c1-27(2)11-16(8-17-4-3-7-37(17)27)31-24-20(29)12-30-26(33-24)32-21-10-22(38-25(15-5-6-15)34-35-36-38)23(9-19(21)28)40-18-13-39-14-18/h9-10,12,15-18H,3-8,11,13-14H2,1-2H3,(H2,30,31,32,33)/t16-,17+/m1/s1 WMEYYVIXYKYZRI-SJORKVTESA-N 161818 US9682976, 255 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161818 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161818&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89853942 355042331 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467799 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2cc(c(O)cc2F)-n2nnnc2C2CC2)ncc1F InChI=1S/C24H29F2N9O/c1-24(2)11-14(8-15-4-3-7-34(15)24)28-21-17(26)12-27-23(30-21)29-18-10-19(20(36)9-16(18)25)35-22(13-5-6-13)31-32-33-35/h9-10,12-15,36H,3-8,11H2,1-2H3,(H2,27,28,29,30)/t14-,15+/m1/s1 OOGVOIGJTLEYKZ-CABCVRRESA-N 161819 US9682976, 256 Interleukin-2 <10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161819&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89853868 355042332 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467800 CC(C)Oc1cc(F)c(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnnc1C1CC1 InChI=1S/C27H35F2N9O/c1-15(2)39-23-11-19(28)21(12-22(23)38-25(16-7-8-16)34-35-36-38)32-26-30-14-20(29)24(33-26)31-17-10-18-6-5-9-37(18)27(3,4)13-17/h11-12,14-18H,5-10,13H2,1-4H3,(H2,30,31,32,33)/t17-,18+/m1/s1 FSNAENBGXFHEJM-MSOLQXFVSA-N 161820 US9682976, 257 Interleukin-2 >10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161820&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89854306 355042333 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467801 CNc1nnnn1-c1cc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)c(F)cc1OC1COC1 InChI=1S/C25H32F2N10O2/c1-25(2)10-14(7-15-5-4-6-36(15)25)30-22-18(27)11-29-23(32-22)31-19-9-20(37-24(28-3)33-34-35-37)21(8-17(19)26)39-16-12-38-13-16/h8-9,11,14-16H,4-7,10,12-13H2,1-3H3,(H,28,33,35)(H2,29,30,31,32)/t14-,15+/m1/s1 UVZFWCHTWOMTKW-CABCVRRESA-N 161821 US9682976, 258 Interleukin-2 <10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161821&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89853615 355042334 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467802 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2cccc(c2)-n2nnnc2S)ncc1F InChI=1S/C21H26FN9S/c1-21(2)11-14(10-15-7-4-8-30(15)21)24-18-17(22)12-23-19(26-18)25-13-5-3-6-16(9-13)31-20(32)27-28-29-31/h3,5-6,9,12,14-15H,4,7-8,10-11H2,1-2H3,(H,27,29,32)(H2,23,24,25,26)/t14-,15+/m1/s1 LECGFLMTZXWVKM-CABCVRRESA-N 161822 US9682976, 259 Interleukin-2 <10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161822&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89854345 355042335 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467803 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2cccc(c2)-n2nnnc2=O)ncc1F 161823 US9682976, 260 Interleukin-2 >10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161823&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89854124 355042336 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467804 CSc1nnnn1-c1cccc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)c1 InChI=1S/C22H28FN9S/c1-22(2)12-15(11-16-8-5-9-31(16)22)25-19-18(23)13-24-20(27-19)26-14-6-4-7-17(10-14)32-21(33-3)28-29-30-32/h4,6-7,10,13,15-16H,5,8-9,11-12H2,1-3H3,(H2,24,25,26,27)/t15-,16+/m1/s1 DRCXNJBQRNGYEM-CVEARBPZSA-N 161824 US9682976, 261 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161824&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89853773 355042337 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467805 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2cccc(c2)-n2nnnc2SC2COC2)ncc1F InChI=1S/C24H30FN9OS/c1-24(2)11-16(10-17-7-4-8-33(17)24)27-21-20(25)12-26-22(29-21)28-15-5-3-6-18(9-15)34-23(30-31-32-34)36-19-13-35-14-19/h3,5-6,9,12,16-17,19H,4,7-8,10-11,13-14H2,1-2H3,(H2,26,27,28,29)/t16-,17+/m1/s1 MBGNFLKVPXQVNZ-SJORKVTESA-N 161825 US9682976, 262 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161825&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89853713 355042338 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467806 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2cccc(c2)-n2nnnc2SC(CO)CO)ncc1F InChI=1S/C24H32FN9O2S/c1-24(2)11-16(10-17-7-4-8-33(17)24)27-21-20(25)12-26-22(29-21)28-15-5-3-6-18(9-15)34-23(30-31-32-34)37-19(13-35)14-36/h3,5-6,9,12,16-17,19,35-36H,4,7-8,10-11,13-14H2,1-2H3,(H2,26,27,28,29)/t16-,17+/m1/s1 WWWLUWIVMXIHCY-SJORKVTESA-N 161826 US9682976, 263 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161826&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89854204 355042339 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467807 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2cccc(c2)-n2nnnc2SC(CN)CO)ncc1F InChI=1S/C24H33FN10OS/c1-24(2)11-16(10-17-7-4-8-34(17)24)28-21-20(25)13-27-22(30-21)29-15-5-3-6-18(9-15)35-23(31-32-33-35)37-19(12-26)14-36/h3,5-6,9,13,16-17,19,36H,4,7-8,10-12,14,26H2,1-2H3,(H2,27,28,29,30)/t16-,17+,19?/m1/s1 NEDOHBXLGMQSTE-FQZXCLDYSA-N 161827 US9682976, 264 Interleukin-2 <10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161827&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89854378 355042340 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467808 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2cccc(c2)-n2nnn(C3COC3)c2=O)ncc1F InChI=1S/C24H30FN9O2/c1-24(2)11-16(10-17-7-4-8-32(17)24)27-21-20(25)12-26-22(29-21)28-15-5-3-6-18(9-15)33-23(35)34(31-30-33)19-13-36-14-19/h3,5-6,9,12,16-17,19H,4,7-8,10-11,13-14H2,1-2H3,(H2,26,27,28,29)/t16-,17+/m1/s1 LDBVTSFNEALJDF-SJORKVTESA-N 161828 US9682976, 265 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161828&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89854426 355042341 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467809 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2cccc(c2)-n2nnnc2SCCO)ncc1F InChI=1S/C23H30FN9OS/c1-23(2)13-16(12-17-7-4-8-32(17)23)26-20-19(24)14-25-21(28-20)27-15-5-3-6-18(11-15)33-22(29-30-31-33)35-10-9-34/h3,5-6,11,14,16-17,34H,4,7-10,12-13H2,1-2H3,(H2,25,26,27,28)/t16-,17+/m1/s1 DAJYCZLHWNYIPA-SJORKVTESA-N 161829 US9682976, 266::US9682976, 271 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161829&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89853543 355042342 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467810 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2cccc(c2)-n2nnn(CCO)c2=O)ncc1F InChI=1S/C23H30FN9O2/c1-23(2)13-16(12-17-7-4-8-31(17)23)26-20-19(24)14-25-21(28-20)27-15-5-3-6-18(11-15)33-22(35)32(9-10-34)29-30-33/h3,5-6,11,14,16-17,34H,4,7-10,12-13H2,1-2H3,(H2,25,26,27,28)/t16-,17+/m1/s1 VDWXALTYAMHPDS-SJORKVTESA-N 161830 US9682976, 267 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161830&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89853730 355042343 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467811 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc3OC(C)(C)c4nn(CCO)c(=O)n4-c3c2)ncc1F InChI=1S/C27H35FN8O3/c1-26(2)14-17(12-18-6-5-9-34(18)26)30-22-19(28)15-29-24(32-22)31-16-7-8-21-20(13-16)36-23(27(3,4)39-21)33-35(10-11-37)25(36)38/h7-8,13,15,17-18,37H,5-6,9-12,14H2,1-4H3,(H2,29,30,31,32)/t17-,18+/m1/s1 LVUDWQSAIHLXRB-MSOLQXFVSA-N 161831 US9682976, 268 Interleukin-2 <10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161831&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89855571 355042344 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467812 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2cccc(c2)-n2nnnc2S(C)(=O)=O)ncc1F InChI=1S/C22H28FN9O2S/c1-22(2)12-15(11-16-8-5-9-31(16)22)25-19-18(23)13-24-20(27-19)26-14-6-4-7-17(10-14)32-21(28-29-30-32)35(3,33)34/h4,6-7,10,13,15-16H,5,8-9,11-12H2,1-3H3,(H2,24,25,26,27)/t15-,16+/m1/s1 UALCKRLAAIOHDP-CVEARBPZSA-N 161832 US9682976, 269 Interleukin-2 <1000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161832 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161832&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89854463 355042345 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467813 CS(=O)c1nnnn1-c1cccc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)c1 InChI=1S/C22H28FN9OS/c1-22(2)12-15(11-16-8-5-9-31(16)22)25-19-18(23)13-24-20(27-19)26-14-6-4-7-17(10-14)32-21(34(3)33)28-29-30-32/h4,6-7,10,13,15-16H,5,8-9,11-12H2,1-3H3,(H2,24,25,26,27)/t15-,16+,34?/m1/s1 IPVMQWOBFJQJGA-JTISZYJISA-N 161833 US9682976, 270 Interleukin-2 <1000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161833 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161833&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89854885 355042346 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467814 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2cccc(c2)-n2nnnc2SCCO)ncc1F InChI=1S/C23H30FN9OS/c1-23(2)13-16(12-17-7-4-8-32(17)23)26-20-19(24)14-25-21(28-20)27-15-5-3-6-18(11-15)33-22(29-30-31-33)35-10-9-34/h3,5-6,11,14,16-17,34H,4,7-10,12-13H2,1-2H3,(H2,25,26,27,28)/t16-,17+/m1/s1 DAJYCZLHWNYIPA-SJORKVTESA-N 161829 US9682976, 266::US9682976, 271 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161829&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89853543 355042342 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467815 Cc1ccc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nn[nH]c1=O 161835 US9682976, 272 Interleukin-2 >10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161835&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89853668 355042347 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467816 Cc1ccc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnn(C)c1=O InChI=1S/C23H30FN9O/c1-14-7-8-15(11-19(14)33-22(34)31(4)29-30-33)27-21-25-13-18(24)20(28-21)26-16-10-17-6-5-9-32(17)23(2,3)12-16/h7-8,11,13,16-17H,5-6,9-10,12H2,1-4H3,(H2,25,26,27,28)/t16-,17+/m1/s1 SITBLSOUBBQNAT-SJORKVTESA-N 161837 US9682976, 273::US9682976, 274 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161837&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89854706 355042348 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467817 Cc1ccc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnn(C)c1=O InChI=1S/C23H30FN9O/c1-14-7-8-15(11-19(14)33-22(34)31(4)29-30-33)27-21-25-13-18(24)20(28-21)26-16-10-17-6-5-9-32(17)23(2,3)12-16/h7-8,11,13,16-17H,5-6,9-10,12H2,1-4H3,(H2,25,26,27,28)/t16-,17+/m1/s1 SITBLSOUBBQNAT-SJORKVTESA-N 161837 US9682976, 273::US9682976, 274 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161837&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89854706 355042348 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467818 Cc1ccc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnn(CCO)c1=O InChI=1S/C24H32FN9O2/c1-15-6-7-16(12-20(15)34-23(36)33(9-10-35)30-31-34)28-22-26-14-19(25)21(29-22)27-17-11-18-5-4-8-32(18)24(2,3)13-17/h6-7,12,14,17-18,35H,4-5,8-11,13H2,1-3H3,(H2,26,27,28,29)/t17-,18+/m1/s1 WQRDIEJQTCEGHC-MSOLQXFVSA-N 161839 US9682976, 275 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161839&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89854775 355042349 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467819 Cc1ccc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnn(C2COC2)c1=O InChI=1S/C25H32FN9O2/c1-15-6-7-16(10-21(15)35-24(36)34(31-32-35)19-13-37-14-19)29-23-27-12-20(26)22(30-23)28-17-9-18-5-4-8-33(18)25(2,3)11-17/h6-7,10,12,17-19H,4-5,8-9,11,13-14H2,1-3H3,(H2,27,28,29,30)/t17-,18+/m1/s1 RJRYGUYWFUAVBS-MSOLQXFVSA-N 161842 US9682976, 276 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161842 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161842&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89854312 355042350 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467820 COc1ccc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnnc1=O 161843 US9682976, 277 Interleukin-2 >10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161843 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161843&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89853777 355042351 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467821 COc1ccc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnn(C)c1=O InChI=1S/C23H30FN9O2/c1-23(2)12-15(10-16-6-5-9-32(16)23)26-20-17(24)13-25-21(28-20)27-14-7-8-19(35-4)18(11-14)33-22(34)31(3)29-30-33/h7-8,11,13,15-16H,5-6,9-10,12H2,1-4H3,(H2,25,26,27,28)/t15-,16+/m1/s1 VNLANJHTNDZABY-CVEARBPZSA-N 161844 US9682976, 278::US9682976, 279 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161844&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89852941 355042352 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467822 COc1ccc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnn(C)c1=O InChI=1S/C23H30FN9O2/c1-23(2)12-15(10-16-6-5-9-32(16)23)26-20-17(24)13-25-21(28-20)27-14-7-8-19(35-4)18(11-14)33-22(34)31(3)29-30-33/h7-8,11,13,15-16H,5-6,9-10,12H2,1-4H3,(H2,25,26,27,28)/t15-,16+/m1/s1 VNLANJHTNDZABY-CVEARBPZSA-N 161844 US9682976, 278::US9682976, 279 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161844&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89852941 355042352 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467823 COc1ccc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnn(CCO)c1=O InChI=1S/C24H32FN9O3/c1-24(2)13-16(11-17-5-4-8-32(17)24)27-21-18(25)14-26-22(29-21)28-15-6-7-20(37-3)19(12-15)34-23(36)33(9-10-35)30-31-34/h6-7,12,14,16-17,35H,4-5,8-11,13H2,1-3H3,(H2,26,27,28,29)/t16-,17+/m1/s1 NZFDRBYUDMGIMU-SJORKVTESA-N 161847 US9682976, 280 Interleukin-2 <1000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161847 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161847&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89853806 355042353 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467824 CSc1nnnn1-c1cc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)ccc1C InChI=1S/C23H30FN9S/c1-14-7-8-15(11-19(14)33-22(34-4)29-30-31-33)27-21-25-13-18(24)20(28-21)26-16-10-17-6-5-9-32(17)23(2,3)12-16/h7-8,11,13,16-17H,5-6,9-10,12H2,1-4H3,(H2,25,26,27,28)/t16-,17+/m1/s1 DWTZEMQQYACNQL-SJORKVTESA-N 161848 US9682976, 281 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161848 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161848&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89855142 355042354 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467825 Cc1ccc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnnc1SCCO InChI=1S/C24H32FN9OS/c1-15-6-7-16(12-20(15)34-23(30-31-32-34)36-10-9-35)28-22-26-14-19(25)21(29-22)27-17-11-18-5-4-8-33(18)24(2,3)13-17/h6-7,12,14,17-18,35H,4-5,8-11,13H2,1-3H3,(H2,26,27,28,29)/t17-,18+/m1/s1 OEDSOUVBWXYGOW-MSOLQXFVSA-N 161850 US9682976, 282 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161850 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161850&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89854995 355042355 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467744 CC(=O)O[C@@H]1COC(Oc2ccc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)cc2C#N)[C@@H](OC(C)=O)[C@@H]1OC(C)=O InChI=1S/C32H39FN6O8/c1-17(40)44-26-16-43-30(28(46-19(3)42)27(26)45-18(2)41)47-25-9-8-21(11-20(25)14-34)37-31-35-15-24(33)29(38-31)36-22-12-23-7-6-10-39(23)32(4,5)13-22/h8-9,11,15,22-23,26-28,30H,6-7,10,12-13,16H2,1-5H3,(H2,35,36,37,38)/t22-,23+,26-,27-,28+,30?/m1/s1 DXGBWYQWPCBGMU-BYJYYVNWSA-N 161759 US9682976, 197 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161759&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89852587 355042286 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467826 Cn1nc2n(-c3cc(Nc4ncc(F)c(N[C@@H]5C[C@@H]6CCCN6C(C)(C)C5)n4)ccc3OC22CCOCC2)c1=O InChI=1S/C28H35FN8O3/c1-27(2)15-18(13-19-5-4-10-36(19)27)31-23-20(29)16-30-25(33-23)32-17-6-7-22-21(14-17)37-24(34-35(3)26(37)38)28(40-22)8-11-39-12-9-28/h6-7,14,16,18-19H,4-5,8-13,15H2,1-3H3,(H2,30,31,32,33)/t18-,19+/m1/s1 DKAUITRWBHQEKV-MOPGFXCFSA-N 161851 US9682976, 283 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161851&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89864056 355042356 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467827 COc1ccc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnnc1OC1COC1 InChI=1S/C25H32FN9O3/c1-25(2)11-16(9-17-5-4-8-34(17)25)28-22-19(26)12-27-23(30-22)29-15-6-7-21(36-3)20(10-15)35-24(31-32-33-35)38-18-13-37-14-18/h6-7,10,12,16-18H,4-5,8-9,11,13-14H2,1-3H3,(H2,27,28,29,30)/t16-,17+/m1/s1 OBOIQQBQMJFUJD-SJORKVTESA-N 161852 US9682976, 284 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161852 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161852&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89853977 355042357 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467828 COc1ccc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnn(C2COC2)c1=O InChI=1S/C25H32FN9O3/c1-25(2)11-16(9-17-5-4-8-33(17)25)28-22-19(26)12-27-23(30-22)29-15-6-7-21(37-3)20(10-15)35-24(36)34(31-32-35)18-13-38-14-18/h6-7,10,12,16-18H,4-5,8-9,11,13-14H2,1-3H3,(H2,27,28,29,30)/t16-,17+/m1/s1 GAZDVEPTZVODIV-SJORKVTESA-N 161853 US9682976, 285 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161853 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161853&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89854573 355042358 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467829 Cc1ccc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnnc1S(C)(=O)=O InChI=1S/C23H30FN9O2S/c1-14-7-8-15(11-19(14)33-22(29-30-31-33)36(4,34)35)27-21-25-13-18(24)20(28-21)26-16-10-17-6-5-9-32(17)23(2,3)12-16/h7-8,11,13,16-17H,5-6,9-10,12H2,1-4H3,(H2,25,26,27,28)/t16-,17+/m1/s1 QQZNAVJIGQFEBH-SJORKVTESA-N 161854 US9682976, 286 Interleukin-2 >10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161854&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89853305 355042359 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467830 Cn1nc2n(-c3cc(Nc4ncc(F)c(N[C@@H]5C[C@@H]6CCCN6C(C)(C)C5)n4)ccc3OC2(CO)CO[Si](C)(C)C(C)(C)C)c1=O InChI=1S/C32H47FN8O4Si/c1-30(2,3)46(7,8)44-19-32(18-42)27-38-39(6)29(43)41(27)24-15-20(11-12-25(24)45-32)36-28-34-17-23(33)26(37-28)35-21-14-22-10-9-13-40(22)31(4,5)16-21/h11-12,15,17,21-22,42H,9-10,13-14,16,18-19H2,1-8H3,(H2,34,35,36,37)/t21-,22+,32?/m1/s1 DYQYFJIDEXGBHW-LNOHLJFZSA-N 161855 US9682976, 287 Interleukin-2 <10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161855&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89855261 355042360 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467831 Cn1nc2n(-c3cc(Nc4ncc(F)c(N[C@@H]5C[C@@H]6CCCN6C(C)(C)C5)n4)ccc3OC2(CO)CO)c1=O InChI=1S/C26H33FN8O4/c1-25(2)11-16(9-17-5-4-8-34(17)25)29-21-18(27)12-28-23(31-21)30-15-6-7-20-19(10-15)35-22(32-33(3)24(35)38)26(13-36,14-37)39-20/h6-7,10,12,16-17,36-37H,4-5,8-9,11,13-14H2,1-3H3,(H2,28,29,30,31)/t16-,17+/m1/s1 LZLQOBGZMNNHLZ-SJORKVTESA-N 161856 US9682976, 288 Interleukin-2 <10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161856 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161856&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89855546 355042361 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467832 Cc1ccc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnn(CC(C)(C)O)c1=O InChI=1S/C26H36FN9O2/c1-16-8-9-17(12-21(16)36-24(37)35(32-33-36)15-26(4,5)38)30-23-28-14-20(27)22(31-23)29-18-11-19-7-6-10-34(19)25(2,3)13-18/h8-9,12,14,18-19,38H,6-7,10-11,13,15H2,1-5H3,(H2,28,29,30,31)/t18-,19+/m1/s1 VTTZBKSZYLYKMO-MOPGFXCFSA-N 161857 US9682976, 289 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161857&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89853823 355042362 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467833 COc1ccc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnn(CC(C)(C)O)c1=O InChI=1S/C26H36FN9O3/c1-25(2)13-17(11-18-7-6-10-34(18)25)29-22-19(27)14-28-23(31-22)30-16-8-9-21(39-5)20(12-16)36-24(37)35(32-33-36)15-26(3,4)38/h8-9,12,14,17-18,38H,6-7,10-11,13,15H2,1-5H3,(H2,28,29,30,31)/t17-,18+/m1/s1 IFXOWFMPASNIHV-MSOLQXFVSA-N 161858 US9682976, 290 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161858&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89853704 355042363 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467834 Cn1nc2COc3ccc(Nc4ncc(F)c(N[C@@H]5C[C@@H]6CCCN6C(C)(C)C5)n4)cc3-n2c1=O InChI=1S/C24H29FN8O2/c1-24(2)11-15(9-16-5-4-8-32(16)24)27-21-17(25)12-26-22(29-21)28-14-6-7-19-18(10-14)33-20(13-35-19)30-31(3)23(33)34/h6-7,10,12,15-16H,4-5,8-9,11,13H2,1-3H3,(H2,26,27,28,29)/t15-,16+/m1/s1 HRPQTQWTNMOUIS-CVEARBPZSA-N 161859 US9682976, 291 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161859 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161859&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89855226 355042364 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467835 Cn1nc2n(-c3cc(Nc4ncc(F)c(N[C@@H]5C[C@@H]6CCCN6C(C)(C)C5)n4)ccc3OCC2(C)O)c1=O InChI=1S/C26H33FN8O3/c1-25(2)12-16(10-17-6-5-9-34(17)25)29-21-18(27)13-28-23(31-21)30-15-7-8-20-19(11-15)35-22(26(3,37)14-38-20)32-33(4)24(35)36/h7-8,11,13,16-17,37H,5-6,9-10,12,14H2,1-4H3,(H2,28,29,30,31)/t16-,17+,26?/m1/s1 NDKGZZSYLTZNNK-XUKFFACESA-N 161860 US9682976, 292::US9682976, 294::US9682976, 295 Interleukin-2 <1000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161860&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89863768 355042365 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467836 Cn1nc2n(-c3cc(Nc4ncc(F)c(N[C@@H]5C[C@@H]6CCCN6C(C)(C)C5)n4)ccc3OC22COC2)c1=O InChI=1S/C26H31FN8O3/c1-25(2)11-16(9-17-5-4-8-34(17)25)29-21-18(27)12-28-23(31-21)30-15-6-7-20-19(10-15)35-22(32-33(3)24(35)36)26(38-20)13-37-14-26/h6-7,10,12,16-17H,4-5,8-9,11,13-14H2,1-3H3,(H2,28,29,30,31)/t16-,17+/m1/s1 SFUTVERCLPQMCW-SJORKVTESA-N 161861 US9682976, 293 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161861&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89863920 355042366 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467837 Cn1nc2n(-c3cc(Nc4ncc(F)c(N[C@@H]5C[C@@H]6CCCN6C(C)(C)C5)n4)ccc3OCC2(C)O)c1=O InChI=1S/C26H33FN8O3/c1-25(2)12-16(10-17-6-5-9-34(17)25)29-21-18(27)13-28-23(31-21)30-15-7-8-20-19(11-15)35-22(26(3,37)14-38-20)32-33(4)24(35)36/h7-8,11,13,16-17,37H,5-6,9-10,12,14H2,1-4H3,(H2,28,29,30,31)/t16-,17+,26?/m1/s1 NDKGZZSYLTZNNK-XUKFFACESA-N 161860 US9682976, 292::US9682976, 294::US9682976, 295 Interleukin-2 <1000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161860&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89863768 355042365 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467838 Cn1nc2n(-c3cc(Nc4ncc(F)c(N[C@@H]5C[C@@H]6CCCN6C(C)(C)C5)n4)ccc3OCC2(C)O)c1=O InChI=1S/C26H33FN8O3/c1-25(2)12-16(10-17-6-5-9-34(17)25)29-21-18(27)13-28-23(31-21)30-15-7-8-20-19(11-15)35-22(26(3,37)14-38-20)32-33(4)24(35)36/h7-8,11,13,16-17,37H,5-6,9-10,12,14H2,1-4H3,(H2,28,29,30,31)/t16-,17+,26?/m1/s1 NDKGZZSYLTZNNK-XUKFFACESA-N 161860 US9682976, 292::US9682976, 294::US9682976, 295 Interleukin-2 <1000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161860&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89863768 355042365 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467839 COCC1(COC)Oc2ccc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)cc2-n2c1nn(C)c2=O InChI=1S/C28H37FN8O4/c1-27(2)13-18(11-19-7-6-10-36(19)27)31-23-20(29)14-30-25(33-23)32-17-8-9-22-21(12-17)37-24(34-35(3)26(37)38)28(41-22,15-39-4)16-40-5/h8-9,12,14,18-19H,6-7,10-11,13,15-16H2,1-5H3,(H2,30,31,32,33)/t18-,19+/m1/s1 OKAZPPKWPSBSKM-MOPGFXCFSA-N 161866 US9682976, 296 Interleukin-2 <1000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161866&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89855036 355042367 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467840 CC1(C)CC[C@H]2C[C@H](CCN12)Nc1nc(Nc2ccc(N3CCOCC3)c(OC(F)F)c2)ncc1F InChI=1S/C25H33F3N6O2/c1-25(2)7-5-18-13-17(6-8-34(18)25)30-22-19(26)15-29-24(32-22)31-16-3-4-20(21(14-16)36-23(27)28)33-9-11-35-12-10-33/h3-4,14-15,17-18,23H,5-13H2,1-2H3,(H2,29,30,31,32)/t17-,18-/m0/s1 IQPBHWOCHCAHDJ-ROUUACIJSA-N 161867 US9682976, 297 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161867&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89853252 355042368 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467841 CC1(C)CC[C@H]2C[C@H](CCN12)Nc1nc(Nc2ccc(OC3COC3)c(OC(F)F)c2)ncc1F InChI=1S/C24H30F3N5O3/c1-24(2)7-5-16-9-15(6-8-32(16)24)29-21-18(25)11-28-23(31-21)30-14-3-4-19(34-17-12-33-13-17)20(10-14)35-22(26)27/h3-4,10-11,15-17,22H,5-9,12-13H2,1-2H3,(H2,28,29,30,31)/t15-,16-/m0/s1 NFQZRUDMOBHDII-HOTGVXAUSA-N 161869 US9682976, 298 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161869&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89852872 355042369 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467842 COc1ccc(Nc2ncc(F)c(N[C@H]3CCN4[C@@H](CCC4(C)C)C3)n2)cc1OC(F)F InChI=1S/C22H28F3N5O2/c1-22(2)8-6-15-10-14(7-9-30(15)22)27-19-16(23)12-26-21(29-19)28-13-4-5-17(31-3)18(11-13)32-20(24)25/h4-5,11-12,14-15,20H,6-10H2,1-3H3,(H2,26,27,28,29)/t14-,15-/m0/s1 NRECFMLBMQIJOJ-GJZGRUSLSA-N 161870 US9682976, 299 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161870&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89852782 355042370 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467843 CC1CN(CC(C)O1)c1ccc(Nc2ncc(F)c(N[C@H]3CCN4[C@@H](CCC4(C)C)C3)n2)cc1OC(F)F InChI=1S/C27H37F3N6O2/c1-16-14-35(15-17(2)37-16)22-6-5-18(12-23(22)38-25(29)30)33-26-31-13-21(28)24(34-26)32-19-8-10-36-20(11-19)7-9-27(36,3)4/h5-6,12-13,16-17,19-20,25H,7-11,14-15H2,1-4H3,(H2,31,32,33,34)/t16?,17?,19-,20-/m0/s1 PQRBREMTEGTKOZ-WXDAQCLHSA-N 161871 US9682976, 300 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161871&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89853096 355042371 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467845 CC1(C)CC[C@H]2C[C@H](CCN12)Nc1nc(Nc2ccc(N3CC4(COC4)C3)c(OC(F)F)c2)ncc1F InChI=1S/C26H33F3N6O2/c1-25(2)7-5-18-9-17(6-8-35(18)25)31-22-19(27)11-30-24(33-22)32-16-3-4-20(21(10-16)37-23(28)29)34-12-26(13-34)14-36-15-26/h3-4,10-11,17-18,23H,5-9,12-15H2,1-2H3,(H2,30,31,32,33)/t17-,18-/m0/s1 ZMEXZTXJCBLOBA-ROUUACIJSA-N 161881 US9682976, 302 Interleukin-2 <1000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161881&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89852779 355042373 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467846 CC1(C)CC[C@H]2C[C@H](CCN12)Nc1nc(Nc2ccc(OCCO)c(OC(F)F)c2)ncc1F InChI=1S/C23H30F3N5O3/c1-23(2)7-5-16-11-15(6-8-31(16)23)28-20-17(24)13-27-22(30-20)29-14-3-4-18(33-10-9-32)19(12-14)34-21(25)26/h3-4,12-13,15-16,21,32H,5-11H2,1-2H3,(H2,27,28,29,30)/t15-,16-/m0/s1 CUDCIIIEKCVLTD-HOTGVXAUSA-N 161884 US9682976, 303 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161884&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89854902 355042374 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467847 CC1(C)CC[C@H]2C[C@H](CCN12)Nc1nc(Nc2ccc(OC3CC(O)C3)c(c2)C#N)ncc1F InChI=1S/C25H31FN6O2/c1-25(2)7-5-18-10-17(6-8-32(18)25)29-23-21(26)14-28-24(31-23)30-16-3-4-22(15(9-16)13-27)34-20-11-19(33)12-20/h3-4,9,14,17-20,33H,5-8,10-12H2,1-2H3,(H2,28,29,30,31)/t17-,18-,19?,20?/m0/s1 VLEHKZNXPSDDFK-VCAKUFKGSA-N 161885 US9682976, 304 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161885&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89853842 355042375 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467848 CC1(C)CC[C@H]2C[C@H](CCN12)Nc1nc(Nc2ccc(OC3CC(O)C3)c(c2)C(F)(F)F)ncc1F InChI=1S/C25H31F4N5O2/c1-24(2)7-5-16-9-15(6-8-34(16)24)31-22-20(26)13-30-23(33-22)32-14-3-4-21(19(10-14)25(27,28)29)36-18-11-17(35)12-18/h3-4,10,13,15-18,35H,5-9,11-12H2,1-2H3,(H2,30,31,32,33)/t15-,16-,17?,18?/m0/s1 MYTBMDGUVASBIE-VYMRPNJYSA-N 161886 US9682976, 305 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161886&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89863984 355042376 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467849 CC1(C)CC[C@H]2C[C@H](CCN12)Nc1nc(Nc2ccc(OC3CC(O)C3)c(OC(F)F)c2)ncc1F InChI=1S/C25H32F3N5O3/c1-25(2)7-5-16-9-15(6-8-33(16)25)30-22-19(26)13-29-24(32-22)31-14-3-4-20(21(10-14)36-23(27)28)35-18-11-17(34)12-18/h3-4,10,13,15-18,23,34H,5-9,11-12H2,1-2H3,(H2,29,30,31,32)/t15-,16-,17?,18?/m0/s1 LMHFXLYMMUYZKL-VYMRPNJYSA-N 161887 US9682976, 306 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161887&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89854509 355042377 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467850 CC1(C)CC[C@H]2C[C@H](CCN12)Nc1nc(Nc2ccc(OCCCO)c(OC(F)F)c2)ncc1F InChI=1S/C24H32F3N5O3/c1-24(2)8-6-17-12-16(7-9-32(17)24)29-21-18(25)14-28-23(31-21)30-15-4-5-19(34-11-3-10-33)20(13-15)35-22(26)27/h4-5,13-14,16-17,22,33H,3,6-12H2,1-2H3,(H2,28,29,30,31)/t16-,17-/m0/s1 LQZYGKYSNUSUPP-IRXDYDNUSA-N 161888 US9682976, 307 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161888&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89863919 355042378 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467851 CC1(C)CC[C@H]2C[C@H](CCN12)Nc1nc(Nc2ccc(N3CC(O)C3)c(OC(F)F)c2)ncc1F InChI=1S/C24H31F3N6O2/c1-24(2)7-5-16-9-15(6-8-33(16)24)29-21-18(25)11-28-23(31-21)30-14-3-4-19(32-12-17(34)13-32)20(10-14)35-22(26)27/h3-4,10-11,15-17,22,34H,5-9,12-13H2,1-2H3,(H2,28,29,30,31)/t15-,16-/m0/s1 HTLXZMBFPMJVHV-HOTGVXAUSA-N 161889 US9682976, 308 Interleukin-2 <1000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161889 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161889&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89853099 355042379 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467852 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@H]4CCN5[C@@H](CCC5(C)C)C4)n3)c(F)cc2OC2CC(O)C2)c1=O InChI=1S/C26H33F2N9O3/c1-26(2)6-4-15-8-14(5-7-36(15)26)30-23-19(28)13-29-24(32-23)31-20-12-21(37-25(39)35(3)33-34-37)22(11-18(20)27)40-17-9-16(38)10-17/h11-17,38H,4-10H2,1-3H3,(H2,29,30,31,32)/t14-,15-,16?,17?/m0/s1 MYEUTKUVSSFVCN-JUVOFCAFSA-N 161890 US9682976, 309 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161890 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161890&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 132471191 355042380 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467853 CC1(C)CC[C@H]2C[C@H](CCN12)Nc1nc(Nc2ccc(OC3CC(C3)OCc3ccccc3)c(Cl)c2)ncc1F InChI=1S/C31H37ClFN5O2/c1-31(2)12-10-23-14-22(11-13-38(23)31)35-29-27(33)18-34-30(37-29)36-21-8-9-28(26(32)15-21)40-25-16-24(17-25)39-19-20-6-4-3-5-7-20/h3-9,15,18,22-25H,10-14,16-17,19H2,1-2H3,(H2,34,35,36,37)/t22-,23-,24?,25?/m0/s1 USRIPHLDZDKOHR-HHLXFHKQSA-N 161891 US9682976, 310::US9682976, 311 Interleukin-2 <10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161891 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161891&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89852614 355042381 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467854 CC1(C)CC[C@H]2C[C@H](CCN12)Nc1nc(Nc2ccc(OC3CC(C3)OCc3ccccc3)c(Cl)c2)ncc1F InChI=1S/C31H37ClFN5O2/c1-31(2)12-10-23-14-22(11-13-38(23)31)35-29-27(33)18-34-30(37-29)36-21-8-9-28(26(32)15-21)40-25-16-24(17-25)39-19-20-6-4-3-5-7-20/h3-9,15,18,22-25H,10-14,16-17,19H2,1-2H3,(H2,34,35,36,37)/t22-,23-,24?,25?/m0/s1 USRIPHLDZDKOHR-HHLXFHKQSA-N 161891 US9682976, 310::US9682976, 311 Interleukin-2 <10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161891 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161891&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89852614 355042381 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467855 CC1(C)CC[C@H]2C[C@H](CCN12)Nc1nc(Nc2ccc(OC3CC(O)C3)c(Cl)c2)ncc1F InChI=1S/C24H31ClFN5O2/c1-24(2)7-5-16-9-15(6-8-31(16)24)28-22-20(26)13-27-23(30-22)29-14-3-4-21(19(25)10-14)33-18-11-17(32)12-18/h3-4,10,13,15-18,32H,5-9,11-12H2,1-2H3,(H2,27,28,29,30)/t15-,16-,17?,18?/m0/s1 NNRKOTVOYJLNEQ-VYMRPNJYSA-N 161893 US9682976, 312::US9682976, 313 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161893 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161893&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89863756 355042382 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467856 CC1(C)CC[C@H]2C[C@H](CCN12)Nc1nc(Nc2ccc(OC3CC(O)C3)c(Cl)c2)ncc1F InChI=1S/C24H31ClFN5O2/c1-24(2)7-5-16-9-15(6-8-31(16)24)28-22-20(26)13-27-23(30-22)29-14-3-4-21(19(25)10-14)33-18-11-17(32)12-18/h3-4,10,13,15-18,32H,5-9,11-12H2,1-2H3,(H2,27,28,29,30)/t15-,16-,17?,18?/m0/s1 NNRKOTVOYJLNEQ-VYMRPNJYSA-N 161893 US9682976, 312::US9682976, 313 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161893 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161893&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89863756 355042382 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467857 C[C@@H](O)COc1cc(F)c(Nc2ncc(C#N)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnn(C)c1=O InChI=1S/C26H33FN10O3/c1-15(38)14-40-22-9-19(27)20(10-21(22)37-25(39)35(4)33-34-37)31-24-29-13-16(12-28)23(32-24)30-17-8-18-6-5-7-36(18)26(2,3)11-17/h9-10,13,15,17-18,38H,5-8,11,14H2,1-4H3,(H2,29,30,31,32)/t15-,17-,18+/m1/s1 IPDNXEBPZBRHFI-NXHRZFHOSA-N 161430 US9682976, 314::US9682976, 90 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161430 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161430&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 86275934 355042185 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467858 CN1C(=O)COc2ccc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)cc12 InChI=1S/C23H29FN6O2/c1-23(2)11-15(9-16-5-4-8-30(16)23)26-21-17(24)12-25-22(28-21)27-14-6-7-19-18(10-14)29(3)20(31)13-32-19/h6-7,10,12,15-16H,4-5,8-9,11,13H2,1-3H3,(H2,25,26,27,28)/t15-,16+/m1/s1 IUBUYJGRTXBXLU-CVEARBPZSA-N 161896 US9682976, 315 Interleukin-2 <10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161896 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161896&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89864156 355042383 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467859 COCC1(COC)Oc2ccc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)cc2-n2nnnc12 InChI=1S/C26H34FN9O3/c1-25(2)12-17(10-18-6-5-9-35(18)25)29-22-19(27)13-28-24(31-22)30-16-7-8-21-20(11-16)36-23(32-33-34-36)26(39-21,14-37-3)15-38-4/h7-8,11,13,17-18H,5-6,9-10,12,14-15H2,1-4H3,(H2,28,29,30,31)/t17-,18+/m1/s1 AWHZRXVLAQWJLE-MSOLQXFVSA-N 161897 US9682976, 316::US9682976, 317 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161897&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89864068 355042384 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467860 COCC1(COC)Oc2ccc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)cc2-n2nnnc12 InChI=1S/C26H34FN9O3/c1-25(2)12-17(10-18-6-5-9-35(18)25)29-22-19(27)13-28-24(31-22)30-16-7-8-21-20(11-16)36-23(32-33-34-36)26(39-21,14-37-3)15-38-4/h7-8,11,13,17-18H,5-6,9-10,12,14-15H2,1-4H3,(H2,28,29,30,31)/t17-,18+/m1/s1 AWHZRXVLAQWJLE-MSOLQXFVSA-N 161897 US9682976, 316::US9682976, 317 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161897&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89864068 355042384 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467861 CN1C(=O)C(C)(C)Oc2ccc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)cc12 InChI=1S/C25H33FN6O2/c1-24(2)13-16(11-17-7-6-10-32(17)24)28-21-18(26)14-27-23(30-21)29-15-8-9-20-19(12-15)31(5)22(33)25(3,4)34-20/h8-9,12,14,16-17H,6-7,10-11,13H2,1-5H3,(H2,27,28,29,30)/t16-,17+/m1/s1 ALNLAUBKTUVNAA-SJORKVTESA-N 161899 US9682976, 318 Interleukin-2 <1000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161899 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161899&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89863769 355042385 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467862 COCCN1C(=O)C(C)(C)Oc2ccc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)cc12 InChI=1S/C27H37FN6O3/c1-26(2)15-18(13-19-7-6-10-34(19)26)30-23-20(28)16-29-25(32-23)31-17-8-9-22-21(14-17)33(11-12-36-5)24(35)27(3,4)37-22/h8-9,14,16,18-19H,6-7,10-13,15H2,1-5H3,(H2,29,30,31,32)/t18-,19+/m1/s1 IHFMEUZBCRAUCV-MOPGFXCFSA-N 161900 US9682976, 319 Interleukin-2 <10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161900&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89864073 355042386 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467863 COC(=O)c1ccc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1C(F)(F)F InChI=1S/C23H27F4N5O2/c1-22(2)11-14(9-15-5-4-8-32(15)22)29-19-18(24)12-28-21(31-19)30-13-6-7-16(20(33)34-3)17(10-13)23(25,26)27/h6-7,10,12,14-15H,4-5,8-9,11H2,1-3H3,(H2,28,29,30,31)/t14-,15+/m1/s1 YAZIZRAUQFVPER-CABCVRRESA-N 161901 US9682976, 320 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161901 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161901&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89863924 355042387 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467864 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(NCC(O)CCl)c(c2)C(F)(F)F)ncc1F InChI=1S/C24H31ClF4N6O/c1-23(2)10-15(8-16-4-3-7-35(16)23)32-21-19(26)13-31-22(34-21)33-14-5-6-20(30-12-17(36)11-25)18(9-14)24(27,28)29/h5-6,9,13,15-17,30,36H,3-4,7-8,10-12H2,1-2H3,(H2,31,32,33,34)/t15-,16+,17?/m1/s1 BZFAFUAQIKJQAS-GARXDOFDSA-N 161902 US9682976, 321 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161902 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161902&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89863759 355042388 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467865 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2OCC(N)=O)c1=O InChI=1S/C24H30F2N10O3/c1-24(2)10-13(7-14-5-4-6-35(14)24)29-21-16(26)11-28-22(31-21)30-17-9-18(36-23(38)34(3)32-33-36)19(8-15(17)25)39-12-20(27)37/h8-9,11,13-14H,4-7,10,12H2,1-3H3,(H2,27,37)(H2,28,29,30,31)/t13-,14+/m1/s1 GQAZWFRQHIXCNZ-KGLIPLIRSA-N 161903 US9682976, 322::US9682976, 323 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161903 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161903&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89864162 355042389 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467866 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2OCC(N)=O)c1=O InChI=1S/C24H30F2N10O3/c1-24(2)10-13(7-14-5-4-6-35(14)24)29-21-16(26)11-28-22(31-21)30-17-9-18(36-23(38)34(3)32-33-36)19(8-15(17)25)39-12-20(27)37/h8-9,11,13-14H,4-7,10,12H2,1-3H3,(H2,27,37)(H2,28,29,30,31)/t13-,14+/m1/s1 GQAZWFRQHIXCNZ-KGLIPLIRSA-N 161903 US9682976, 322::US9682976, 323 Interleukin-2 <10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161903 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161903&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89864162 355042389 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467867 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(N3CC(C3)C(N)=O)c(c2)C(F)(F)F)ncc1F InChI=1S/C25H31F4N7O/c1-24(2)10-16(8-17-4-3-7-36(17)24)32-22-19(26)11-31-23(34-22)33-15-5-6-20(18(9-15)25(27,28)29)35-12-14(13-35)21(30)37/h5-6,9,11,14,16-17H,3-4,7-8,10,12-13H2,1-2H3,(H2,30,37)(H2,31,32,33,34)/t16-,17+/m1/s1 ZZXLQYWKCLGXKL-SJORKVTESA-N 161905 US9682976, 324 Interleukin-2 <1000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161905 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161905&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89864159 355042390 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467868 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(NCC(CCl)C(N)=O)c(c2)C(F)(F)F)ncc1F InChI=1S/C25H32ClF4N7O/c1-24(2)10-16(8-17-4-3-7-37(17)24)34-22-19(27)13-33-23(36-22)35-15-5-6-20(18(9-15)25(28,29)30)32-12-14(11-26)21(31)38/h5-6,9,13-14,16-17,32H,3-4,7-8,10-12H2,1-2H3,(H2,31,38)(H2,33,34,35,36)/t14?,16-,17+/m1/s1 NHKUNOAILIMEGP-XMKPYSNPSA-N 161906 US9682976, 325 Interleukin-2 <1000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161906 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161906&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89863760 355042391 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467869 CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(N3CC(O)C3)c(c2)C(F)(F)F)ncc1F InChI=1S/C24H30F4N6O/c1-23(2)10-15(8-16-4-3-7-34(16)23)30-21-19(25)11-29-22(32-21)31-14-5-6-20(33-12-17(35)13-33)18(9-14)24(26,27)28/h5-6,9,11,15-17,35H,3-4,7-8,10,12-13H2,1-2H3,(H2,29,30,31,32)/t15-,16+/m1/s1 UFQPPSMJKRZPBN-CVEARBPZSA-N 161907 US9682976, 326 Interleukin-2 <500 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161907 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161907&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89863999 355042392 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467870 CNC(=O)c1ccc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1Cl InChI=1S/C22H28ClFN6O/c1-22(2)11-14(9-15-5-4-8-30(15)22)27-19-18(24)12-26-21(29-19)28-13-6-7-16(17(23)10-13)20(31)25-3/h6-7,10,12,14-15H,4-5,8-9,11H2,1-3H3,(H,25,31)(H2,26,27,28,29)/t14-,15+/m1/s1 UQVSEWRVTPZKIS-CABCVRRESA-N 161908 US9682976, 327 Interleukin-2 <1000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161908&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89852757 355042393 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467871 Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)ccc2N2CC(O)C2)c1=O InChI=1S/C25H33FN10O2/c1-25(2)11-16(9-17-5-4-8-35(17)25)28-22-19(26)12-27-23(30-22)29-15-6-7-20(34-13-18(37)14-34)21(10-15)36-24(38)33(3)31-32-36/h6-7,10,12,16-18,37H,4-5,8-9,11,13-14H2,1-3H3,(H2,27,28,29,30)/t16-,17+/m1/s1 PHZOMBJGVXBLAR-SJORKVTESA-N 161909 US9682976, 328 Interleukin-2 <10000 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161909&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 71811776 355042394 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 467844 CC1(C)CC[C@H]2C[C@H](CCN12)Nc1nc(Nc2cc(c(cc2F)C2CC2)-n2nnnc2C2COC2)ncc1F InChI=1S/C27H33F2N9O/c1-27(2)7-5-18-9-17(6-8-37(18)27)31-24-21(29)12-30-26(33-24)32-22-11-23(19(10-20(22)28)15-3-4-15)38-25(34-35-36-38)16-13-39-14-16/h10-12,15-18H,3-9,13-14H2,1-2H3,(H2,30,31,32,33)/t17-,18-/m0/s1 GQKJYLNNJNAJFZ-ROUUACIJSA-N 161873 US9682976, 301 Interleukin-2 <100 US Patent 10.7270/Q2DJ5CT2 aid1794940 US9682976 Singh, R; Duncton, M; Zhang, J; Alvarez, S; Tso, K; Holland, S; Yen, R; Kolluri, R; Heckrodt, T; Chen, Y; Masuda, E; Li, H; Payan, DG; Kelley, R Rigel Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=161873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=161873&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89853648 355042372 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 50109093 OC[C@H]1O[C@@H](Oc2ccc3c(c2)occ(-c2ccc(O)cc2)c3=O)[C@H](O)[C@@H](O)[C@@H]1O InChI=1S/C21H20O9/c22-8-16-18(25)19(26)20(27)21(30-16)29-12-5-6-13-15(7-12)28-9-14(17(13)24)10-1-3-11(23)4-2-10/h1-7,9,16,18-23,25-27H,8H2/t16-,18-,19+,20-,21-/m1/s1 KYQZWONCHDNPDP-QNDFHXLGSA-N 50409029 DAIDZIN Interleukin-2 3380 ChEMBL 10.1016/j.ejmech.2014.06.037 10.7270/Q2NG4S7H 24974349 Chen, L; Du, J; Dai, Q; Zhang, H; Pang, W; Hu, J The Second People's Hospital of Fujian Provinc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50409029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50409029&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search DZN 2VLE 107971 163358053 42202 DB02115 C03400 ZINC04098610 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 50109096 COC(=O)C1=CO[C@@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)\C(=C/C)[C@@H]1CC(=O)OC[C@H]1O[C@@H](OCCc2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O InChI=1S/C31H42O17/c1-3-16-17(18(28(41)42-2)12-45-29(16)48-31-27(40)24(37)22(35)19(11-32)46-31)10-21(34)44-13-20-23(36)25(38)26(39)30(47-20)43-9-8-14-4-6-15(33)7-5-14/h3-7,12,17,19-20,22-27,29-33,35-40H,8-11,13H2,1-2H3/b16-3-/t17-,19+,20+,22+,23+,24-,25-,26+,27+,29-,30+,31-/m0/s1 STKUCSFEBXPTAY-GSUVRYNNSA-N 50021396 CHEMBL3289607 Interleukin-2 2.59 ChEMBL 10.1016/j.ejmech.2014.06.037 10.7270/Q2NG4S7H 24974349 Chen, L; Du, J; Dai, Q; Zhang, H; Pang, W; Hu, J The Second People's Hospital of Fujian Provinc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021396 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021396&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 11146840 103932100 CHEMBL3289607 C03400 ZINC36189889 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 50109098 COc1ccc(cc1O)-c1coc2cc(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)ccc2c1=O InChI=1S/C22H22O10/c1-29-15-5-2-10(6-14(15)24)13-9-30-16-7-11(3-4-12(16)18(13)25)31-22-21(28)20(27)19(26)17(8-23)32-22/h2-7,9,17,19-24,26-28H,8H2,1H3/t17-,19-,20+,21-,22-/m1/s1 WACBUPFEGWUGPB-MIUGBVLSSA-N 50021397 CHEMBL3289608 Interleukin-2 36 ChEMBL 10.1016/j.ejmech.2014.06.037 10.7270/Q2NG4S7H 24974349 Chen, L; Du, J; Dai, Q; Zhang, H; Pang, W; Hu, J The Second People's Hospital of Fujian Provinc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021397 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021397&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 5318267 103932101 CHEMBL3289608 C03400 ZINC29239488 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 50109099 OC[C@H]1O[C@@H](Oc2cc(O)c3c(c2)oc(cc3=O)-c2ccc(O)c(O)c2)[C@H](O)[C@@H](O)[C@@H]1O InChI=1S/C21H20O11/c22-7-16-18(27)19(28)20(29)21(32-16)30-9-4-12(25)17-13(26)6-14(31-15(17)5-9)8-1-2-10(23)11(24)3-8/h1-6,16,18-25,27-29H,7H2/t16-,18-,19+,20-,21-/m1/s1 PEFNSGRTCBGNAN-QNDFHXLGSA-N 50241242 2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen-7-yl beta-D-glucopyranoside::7-(beta-D-glucopyranosyloxy)-5-hydroxy-2-(3,4-dihydroxyphenyl)-4H-chromen-4-one::7-Glucoluteolin::7-Glucosylluteolin::CHEMBL233929::Cinaroside::Cynaroside::Luteolin 7-O-β-D-glucoside (13)::Luteolin 7-O-glucopyranoside::Luteolin 7-O-glucoside::Luteolin 7-glucoside::Luteolin 7-monoglucoside::Luteolin-7-glucoside::Luteoloside::cid_5280637::luteolin 7-O-beta-D-glucoside Interleukin-2 20 ChEMBL 10.1016/j.ejmech.2014.06.037 10.7270/Q2NG4S7H 24974349 Chen, L; Du, J; Dai, Q; Zhang, H; Pang, W; Hu, J The Second People's Hospital of Fujian Provinc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50241242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50241242&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 5280637 104098671 27994 CHEMBL233929 C03400 ZINC04096258 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 50109101 COc1ccc(cc1)-c1coc2cc(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)ccc2c1=O InChI=1S/C22H22O9/c1-28-12-4-2-11(3-5-12)15-10-29-16-8-13(6-7-14(16)18(15)24)30-22-21(27)20(26)19(25)17(9-23)31-22/h2-8,10,17,19-23,25-27H,9H2,1H3/t17-,19-,20+,21-,22-/m1/s1 MGJLSBDCWOSMHL-MIUGBVLSSA-N 50409313 ONONIN Interleukin-2 120 ChEMBL 10.1016/j.ejmech.2014.06.037 10.7270/Q2NG4S7H 24974349 Chen, L; Du, J; Dai, Q; Zhang, H; Pang, W; Hu, J The Second People's Hospital of Fujian Provinc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50409313 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50409313&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 442813 163358337 7775 C03400 ZINC01081322 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 50109104 COc1ccc(cc1)-c1coc2cc(O)ccc2c1=O InChI=1S/C16H12O4/c1-19-12-5-2-10(3-6-12)14-9-20-15-8-11(17)4-7-13(15)16(14)18/h2-9,17H,1H3 HKQYGTCOTHHOMP-UHFFFAOYSA-N 50021398 CHEBI:18088::FORMONONETIN::NSC-93360 Interleukin-2 5470 ChEMBL 10.1016/j.ejmech.2014.06.037 10.7270/Q2NG4S7H 24974349 Chen, L; Du, J; Dai, Q; Zhang, H; Pang, W; Hu, J The Second People's Hospital of Fujian Provinc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021398&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 5280378 103932102 18088 C00858 ZINC43938698 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 50109105 NC(=N)NC(C1CCCCC1)C(=O)NCC(=O)N1CCC(CC1)c1cc(n[nH]1)-c1cccc(Cl)c1Cl InChI=1S/C25H33Cl2N7O2/c26-18-8-4-7-17(22(18)27)20-13-19(32-33-20)15-9-11-34(12-10-15)21(35)14-30-24(36)23(31-25(28)29)16-5-2-1-3-6-16/h4,7-8,13,15-16,23H,1-3,5-6,9-12,14H2,(H,30,36)(H,32,33)(H4,28,29,31) SSSXBBASYYVGCI-UHFFFAOYSA-N 50021399 CHEMBL3289611 Interleukin-2 55 ChEMBL 10.1016/j.ejmech.2014.06.037 10.7270/Q2NG4S7H 24974349 Chen, L; Du, J; Dai, Q; Zhang, H; Pang, W; Hu, J The Second People's Hospital of Fujian Provinc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021399 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021399&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search FRB 1PW6 23530924 103932103 CHEMBL3289611 ZINC36189941 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 50109106 C[C@H]1[C@H]2[C@H](C[C@H]3[C@@H]4CC=C5C[C@H](CC[C@]5(C)[C@H]4CC[C@]23C)O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)O[C@]11CC[C@@H](C)CO1 InChI=1S/C33H52O8/c1-17-7-12-33(38-16-17)18(2)26-24(41-33)14-23-21-6-5-19-13-20(8-10-31(19,3)22(21)9-11-32(23,26)4)39-30-29(37)28(36)27(35)25(15-34)40-30/h5,17-18,20-30,34-37H,6-16H2,1-4H3/t17-,18+,20+,21-,22+,23+,24+,25-,26+,27-,28+,29-,30-,31+,32+,33-/m1/s1 WXMARHKAXWRNDM-GAMIEDRGSA-N 50021400 CHEBI:74020::DISOGLUSIDE Interleukin-2 0.029 ChEMBL 10.1016/j.ejmech.2014.06.037 10.7270/Q2NG4S7H 24974349 Chen, L; Du, J; Dai, Q; Zhang, H; Pang, W; Hu, J The Second People's Hospital of Fujian Provinc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021400 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021400&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 11827970 103932104 C03400 ZINC29239427 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 50858382 CC(C)CC([NH+]=C(N)N)C(=O)NCC(=O)N1CCC(CC1)c1cc(nn1C)-c1ccc(OCc2ccc(o2)C([O-])=O)c(Cl)c1Cl InChI=1S/C30H37Cl2N7O6/c1-16(2)12-21(36-30(33)34)28(41)35-14-25(40)39-10-8-17(9-11-39)22-13-20(37-38(22)3)19-5-7-23(27(32)26(19)31)44-15-18-4-6-24(45-18)29(42)43/h4-7,13,16-17,21H,8-12,14-15H2,1-3H3,(H,35,41)(H,42,43)(H4,33,34,36) VNZHOIDQBPFEJU-UHFFFAOYSA-N 50229786 5-[2,3-DICHLORO-4-(5-{1-[2-(2-GUANIDINO-4-METHYL-PENTANOYLAMINO)-ACETYL]-PIPERIDIN-4-YL}-1-METHYL-1H-PYRAZOL-3-YL)-PHENOXYMETHYL]-FURAN-2-CARBOXYLIC ACID::5-[2,3-Dichloro-4-(5-{1-[2-((R)-2-guanidino-4-methyl-1-oxo-pentylamino)-acetyl]-piperidin-4-yl}-1-methyl-1H-pyrazol-3-yl)-phenoxymethyl]-furan-2-carboxylic acid::5-[2,3-Dichloro-4-(5-{1-[2-((R)-2-guanidino-4-methyl-pentanoylamino)-acetyl]-piperidin-4-yl}-1-methyl-1H-pyrazol-3-yl)-phenoxymethyl]-furan-2-carboxylic acid::CHEMBL429852::SP-4206 Interleukin-2 60 ChEMBL 10.1038/nature06526 10.7270/Q24Q7VTV 18075579 Wells, JA; McClendon, CL University of California San Francisco http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50229786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50229786&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 91935514 104098213 47417 CHEMBL429852 ZINC03990365 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 50745792 Cn1c(Cc2nn(C)c(=O)c3ccccc23)nnc1SCC(=O)Nc1ccc(Cl)cc1Cl InChI=1S/C21H18Cl2N6O2S/c1-28-18(10-17-13-5-3-4-6-14(13)20(31)29(2)27-17)25-26-21(28)32-11-19(30)24-16-8-7-12(22)9-15(16)23/h3-9H,10-11H2,1-2H3,(H,24,30) RUZXXRYUPQCFAF-UHFFFAOYSA-N 50238648 CHEMBL4102828 Interleukin-2 10500 ChEMBL 10.1021/acs.jmedchem.7b00485 10.7270/Q20V8G2Z 28657314 Quéméner, A; Maillasson, M; Arzel, L; Sicard, B; Vomiandry, R; Mortier, E; Dubreuil, D; Jacques, Y; Lebreton, J; Mathé-Allainmat, M University of Nantes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50238648 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50238648&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 44449911 85716730 CHEMBL4102828 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 50745793 Cn1c(Cc2nn(C)c(=O)c3ccccc23)nnc1SCCCCCCCC(=O)Nc1ccc(Cl)cc1Cl InChI=1S/C27H30Cl2N6O2S/c1-34-24(17-23-19-10-7-8-11-20(19)26(37)35(2)33-23)31-32-27(34)38-15-9-5-3-4-6-12-25(36)30-22-14-13-18(28)16-21(22)29/h7-8,10-11,13-14,16H,3-6,9,12,15,17H2,1-2H3,(H,30,36) DDNCGNPWKAPRTO-UHFFFAOYSA-N 50238649 CHEMBL4103753 Interleukin-2 8000 ChEMBL 10.1021/acs.jmedchem.7b00485 10.7270/Q20V8G2Z 28657314 Quéméner, A; Maillasson, M; Arzel, L; Sicard, B; Vomiandry, R; Mortier, E; Dubreuil, D; Jacques, Y; Lebreton, J; Mathé-Allainmat, M University of Nantes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50238649 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50238649&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 44450154 85717089 CHEMBL4103753 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 50745794 Cn1c(Cc2nn(C)c(=O)c3ccccc23)nnc1SCCCCCCCC(=O)Nc1ccc(Br)cc1Br InChI=1S/C27H30Br2N6O2S/c1-34-24(17-23-19-10-7-8-11-20(19)26(37)35(2)33-23)31-32-27(34)38-15-9-5-3-4-6-12-25(36)30-22-14-13-18(28)16-21(22)29/h7-8,10-11,13-14,16H,3-6,9,12,15,17H2,1-2H3,(H,30,36) PKKFNDWUWXETHI-UHFFFAOYSA-N 50238650 CHEMBL4085144 Interleukin-2 10000 ChEMBL 10.1021/acs.jmedchem.7b00485 10.7270/Q20V8G2Z 28657314 Quéméner, A; Maillasson, M; Arzel, L; Sicard, B; Vomiandry, R; Mortier, E; Dubreuil, D; Jacques, Y; Lebreton, J; Mathé-Allainmat, M University of Nantes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50238650 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50238650&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 44450155 85717090 CHEMBL4085144 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 50745795 COc1ccc(NC(=O)CCCCCCCSc2nnc(Cc3nn(C)c(=O)c4ccccc34)n2C)c(O)c1 InChI=1S/C28H34N6O4S/c1-33-25(18-23-20-11-8-9-12-21(20)27(37)34(2)32-23)30-31-28(33)39-16-10-6-4-5-7-13-26(36)29-22-15-14-19(38-3)17-24(22)35/h8-9,11-12,14-15,17,35H,4-7,10,13,16,18H2,1-3H3,(H,29,36) BYFDIQKCADADCS-UHFFFAOYSA-N 50238651 CHEMBL4093847 Interleukin-2 12500 ChEMBL 10.1021/acs.jmedchem.7b00485 10.7270/Q20V8G2Z 28657314 Quéméner, A; Maillasson, M; Arzel, L; Sicard, B; Vomiandry, R; Mortier, E; Dubreuil, D; Jacques, Y; Lebreton, J; Mathé-Allainmat, M University of Nantes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50238651 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50238651&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 44450182 85717132 CHEMBL4093847 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 50745796 CCOC(=O)c1cccc(NC(=O)CCCCCCCSc2nnc(Cc3nn(C)c(=O)c4ccccc34)n2C)c1 InChI=1S/C30H36N6O4S/c1-4-40-29(39)21-13-12-14-22(19-21)31-27(37)17-8-6-5-7-11-18-41-30-33-32-26(35(30)2)20-25-23-15-9-10-16-24(23)28(38)36(3)34-25/h9-10,12-16,19H,4-8,11,17-18,20H2,1-3H3,(H,31,37) GWNFQAKCJYEJEW-UHFFFAOYSA-N 50238646 CHEMBL4101389 Interleukin-2 23100 ChEMBL 10.1021/acs.jmedchem.7b00485 10.7270/Q20V8G2Z 28657314 Quéméner, A; Maillasson, M; Arzel, L; Sicard, B; Vomiandry, R; Mortier, E; Dubreuil, D; Jacques, Y; Lebreton, J; Mathé-Allainmat, M University of Nantes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50238646 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50238646&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 44450088 85716987 CHEMBL4101389 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 50745801 COc1ccc(NC(=O)CCCCCCCSc2nnc(Cc3nn(C)c(=O)c4ccccc34)n2C)c(OC)c1 InChI=1S/C29H36N6O4S/c1-34-26(19-24-21-12-9-10-13-22(21)28(37)35(2)33-24)31-32-29(34)40-17-11-7-5-6-8-14-27(36)30-23-16-15-20(38-3)18-25(23)39-4/h9-10,12-13,15-16,18H,5-8,11,14,17,19H2,1-4H3,(H,30,36) JSBBJYKDXCLNSI-UHFFFAOYSA-N 50238652 CHEMBL4066271 Interleukin-2 27600 ChEMBL 10.1021/acs.jmedchem.7b00485 10.7270/Q20V8G2Z 28657314 Quéméner, A; Maillasson, M; Arzel, L; Sicard, B; Vomiandry, R; Mortier, E; Dubreuil, D; Jacques, Y; Lebreton, J; Mathé-Allainmat, M University of Nantes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50238652 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50238652&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 44450184 85717134 CHEMBL4066271 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 773704 COc1ccc(cc1-c1ccc(NC(=O)c2snnc2C)cc1)C1=NOC(C)(C)C1=O InChI=1S/C22H20N4O4S/c1-12-19(31-26-24-12)21(28)23-15-8-5-13(6-9-15)16-11-14(7-10-17(16)29-4)18-20(27)22(2,3)30-25-18/h5-11H,1-4H3,(H,23,28) LMRKQWYLNWUYRW-UHFFFAOYSA-N 387262 N-(5′- (5,5-Dimethyl-4-oxo- 4,5-dihydroisoxazol- 3-yl)-2′-methoxy- [1,1′-biphenyl]-4-yl)- 4-methyl-1,2,3- thiadiazole-5- carboxamide::US10292981, Example 16 Interleukin-2 <100.0 US Patent 10.7270/Q2D50Q8B aid1798707 US10292981 Irlapati, NR; Deshmukh, GK; Karche, VP; Jachak, SM; Sinha, N; Palle, VP; Kamboj, RK LUPIN LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387262 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387262&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 57330382 404856377 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 773705 CC(=O)Nc1ccc(cc1-c1ccc(NC(=O)c2c(F)cccc2F)cc1)C1=NOC(C)(C)C1=O InChI=1S/C26H21F2N3O4/c1-14(32)29-21-12-9-16(23-24(33)26(2,3)35-31-23)13-18(21)15-7-10-17(11-8-15)30-25(34)22-19(27)5-4-6-20(22)28/h4-13H,1-3H3,(H,29,32)(H,30,34) OJFPHWNCWJVHFQ-UHFFFAOYSA-N 387263 N-(2′- acetamido-5′-(5,5- dimethyl-4-oxo-4,5- dihydroisoxazol-3- yl)-[1,1′-biphenyl]-4- yl)-2,6- difluorobenzamide::US10292981, Example 19 Interleukin-2 <100.0 US Patent 10.7270/Q2D50Q8B aid1798707 US10292981 Irlapati, NR; Deshmukh, GK; Karche, VP; Jachak, SM; Sinha, N; Palle, VP; Kamboj, RK LUPIN LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387263&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 57330438 404856378 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 773703 Cc1ccc(cc1-c1ccc(NC(=O)c2c(F)cccc2F)cc1)C1=NOC(C)(C)C1=O InChI=1S/C25H20F2N2O3/c1-14-7-8-16(22-23(30)25(2,3)32-29-22)13-18(14)15-9-11-17(12-10-15)28-24(31)21-19(26)5-4-6-20(21)27/h4-13H,1-3H3,(H,28,31) QCIJFVBUOPDNBC-UHFFFAOYSA-N 387261 N-(5′- (5,5-Dimethyl-4-oxo- 4,5-dihydroisoxazol- 3-yl)-2′-methyl-[1,1′- biphenyl]-4-yl-2,6- difluorobenzamide::US10292981, Example 3 Interleukin-2 <100.0 US Patent 10.7270/Q2D50Q8B aid1798707 US10292981 Irlapati, NR; Deshmukh, GK; Karche, VP; Jachak, SM; Sinha, N; Palle, VP; Kamboj, RK LUPIN LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387261 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387261&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 56958618 404856376 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 773706 Cc1c(cccc1-c1ccc(NC(=O)c2c(F)cccc2F)cc1)C1=NOC(C)(C)C1=O InChI=1S/C25H20F2N2O3/c1-14-17(6-4-7-18(14)22-23(30)25(2,3)32-29-22)15-10-12-16(13-11-15)28-24(31)21-19(26)8-5-9-20(21)27/h4-13H,1-3H3,(H,28,31) NFSNROSXMGPXOR-UHFFFAOYSA-N 387264 N-(3′- (5,5-Dimethyl-4-oxo- 4,5-dihydroisoxazol- 3-yl)-2′-methyl-[1,1′- biphenyl]-4-yl)-2,6- difluorobenzamide::US10292981, Example 29 Interleukin-2 <100.0 US Patent 10.7270/Q2D50Q8B aid1798707 US10292981 Irlapati, NR; Deshmukh, GK; Karche, VP; Jachak, SM; Sinha, N; Palle, VP; Kamboj, RK LUPIN LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387264&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 57330443 404856379 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 773707 Cc1ccc(cc1-c1ccc(NC(=O)c2c(F)cccc2F)cc1)-c1nn(C)c(=O)o1 InChI=1S/C23H17F2N3O3/c1-13-6-7-15(22-27-28(2)23(30)31-22)12-17(13)14-8-10-16(11-9-14)26-21(29)20-18(24)4-3-5-19(20)25/h3-12H,1-2H3,(H,26,29) NKLWMFLCTSEIFM-UHFFFAOYSA-N 387265 2,6- Difluoro-N-(2′- methyl-5′-(4-methyl- 5-oxo-4,5-dihydro- 1,3,4-oxadiazol-2-yl)- [1,1′-biphenyl]-4- yl)benzamide::US10292981, Example 33 Interleukin-2 <100.0 US Patent 10.7270/Q2D50Q8B aid1798707 US10292981 Irlapati, NR; Deshmukh, GK; Karche, VP; Jachak, SM; Sinha, N; Palle, VP; Kamboj, RK LUPIN LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387265 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387265&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89763695 404856380 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 773708 CCn1nc(oc1=O)-c1ccc(C)c(c1)-c1ccc(NC(=O)c2c(F)cccc2F)cc1 InChI=1S/C24H19F2N3O3/c1-3-29-24(31)32-23(28-29)16-8-7-14(2)18(13-16)15-9-11-17(12-10-15)27-22(30)21-19(25)5-4-6-20(21)26/h4-13H,3H2,1-2H3,(H,27,30) OWPMRXOYWPQBNY-UHFFFAOYSA-N 387266 N-(5′- (4-Ethyl-5-oxo-4,5- dihydro-1,3,4- oxadiazol-2-yl)-2′- methyl-[1,1′- biphenyl]-4-yl)-2,6- difluorobenzamide::US10292981, Example 34 Interleukin-2 <100.0 US Patent 10.7270/Q2D50Q8B aid1798707 US10292981 Irlapati, NR; Deshmukh, GK; Karche, VP; Jachak, SM; Sinha, N; Palle, VP; Kamboj, RK LUPIN LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387266&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 67517275 404856381 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 773709 COc1ccc(cc1-c1ccc(NC(=O)c2c(F)cccc2F)cc1)-c1nn(C)c(=O)o1 InChI=1S/C23H17F2N3O4/c1-28-23(30)32-22(27-28)14-8-11-19(31-2)16(12-14)13-6-9-15(10-7-13)26-21(29)20-17(24)4-3-5-18(20)25/h3-12H,1-2H3,(H,26,29) OQWQDUSTDRSTKO-UHFFFAOYSA-N 387267 2,6- Difluoro-N-(2′- methoxy-5′-(4- methyl-5-oxo-4,5- dihydro-1,3,4- oxadiazol-2-yl)[1,1′- biphenyl]-4- yl)benzamide::US10292981, Example 40 Interleukin-2 <100.0 US Patent 10.7270/Q2D50Q8B aid1798707 US10292981 Irlapati, NR; Deshmukh, GK; Karche, VP; Jachak, SM; Sinha, N; Palle, VP; Kamboj, RK LUPIN LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387267 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387267&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 57330501 404856382 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 773710 Cn1nc(oc1=O)-c1ccc(Cl)c(c1)-c1ccc(NC(=O)c2c(F)cccc2F)cc1 InChI=1S/C22H14ClF2N3O3/c1-28-22(30)31-21(27-28)13-7-10-16(23)15(11-13)12-5-8-14(9-6-12)26-20(29)19-17(24)3-2-4-18(19)25/h2-11H,1H3,(H,26,29) VBGWOAOSCPKNMD-UHFFFAOYSA-N 387268 N-(2′- Chloro-5′-(4-methyl- 5-oxo-4,5-dihydro- 1,3,4-oxadiazol-2-yl)- [1,1′-biphenyl]-4-yl)- 2,6- difluorobenzamide::US10292981, Example 46 Interleukin-2 <100.0 US Patent 10.7270/Q2D50Q8B aid1798707 US10292981 Irlapati, NR; Deshmukh, GK; Karche, VP; Jachak, SM; Sinha, N; Palle, VP; Kamboj, RK LUPIN LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387268 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387268&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 57330504 404856383 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 773711 Cc1ccc(cc1-c1cnc(NC(=O)c2c(F)cccc2Cl)cn1)C1=NOC(C)(C)C1=O InChI=1S/C23H18ClFN4O3/c1-12-7-8-13(20-21(30)23(2,3)32-29-20)9-14(12)17-10-27-18(11-26-17)28-22(31)19-15(24)5-4-6-16(19)25/h4-11H,1-3H3,(H,27,28,31) KFLVVCARMXCDDZ-UHFFFAOYSA-N 387269 2- Chloro-N-(5-(5-(5,5- dimethyl-4-oxo-4,5- dihydroisoxazol-3- yl)-2-methyl phenyl)pyrazin-2-yl)- 6-fluorobenzamide::US10292981, Example 80 Interleukin-2 <100.0 US Patent 10.7270/Q2D50Q8B aid1798707 US10292981 Irlapati, NR; Deshmukh, GK; Karche, VP; Jachak, SM; Sinha, N; Palle, VP; Kamboj, RK LUPIN LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387269 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387269&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 67515178 404856384 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 773712 Cc1ccc(cc1-c1cnc(NC(=O)c2c(F)cccc2F)cn1)-c1nn(C)c(=O)o1 InChI=1S/C21H15F2N5O3/c1-11-6-7-12(20-27-28(2)21(30)31-20)8-13(11)16-9-25-17(10-24-16)26-19(29)18-14(22)4-3-5-15(18)23/h3-10H,1-2H3,(H,25,26,29) NQLUEONWNDPITM-UHFFFAOYSA-N 387270 2,6- Difluoro-N-(5-(2- methyl-5-(4- methyl-5-oxo-4,5- dihydro-1,3,4- oxadiazol-2- yl)phenyl)pyrazin- 2-yl)benzamide::US10292981, Example 87 Interleukin-2 <100.0 US Patent 10.7270/Q2D50Q8B aid1798707 US10292981 Irlapati, NR; Deshmukh, GK; Karche, VP; Jachak, SM; Sinha, N; Palle, VP; Kamboj, RK LUPIN LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387270 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387270&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89763991 404856385 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 773713 COc1ccc(cc1-c1cnc(NC(=O)c2c(F)cccc2F)cn1)-c1nn(C)c(=O)o1 InChI=1S/C21H15F2N5O4/c1-28-21(30)32-20(27-28)11-6-7-16(31-2)12(8-11)15-9-25-17(10-24-15)26-19(29)18-13(22)4-3-5-14(18)23/h3-10H,1-2H3,(H,25,26,29) WBHMQSQHURVXPI-UHFFFAOYSA-N 387271 2,6- Difluoro-N-(5-(2- methoxy-5-(4- methyl-5-oxo-4,5- dihydro-1,3,4- oxadiazol-2- yl)phenyl)pyrazin- 2-yl)benzamide::US10292981, Example 93 Interleukin-2 <100.0 US Patent 10.7270/Q2D50Q8B aid1798707 US10292981 Irlapati, NR; Deshmukh, GK; Karche, VP; Jachak, SM; Sinha, N; Palle, VP; Kamboj, RK LUPIN LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387271 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387271&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 67515017 404856386 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 773714 Cc1ccc(cc1-c1cnc(NC(=O)c2c(F)cncc2F)cn1)C1=NOC(C)(C)C1=O InChI=1S/C22H17F2N5O3/c1-11-4-5-12(19-20(30)22(2,3)32-29-19)6-13(11)16-9-27-17(10-26-16)28-21(31)18-14(23)7-25-8-15(18)24/h4-10H,1-3H3,(H,27,28,31) VWWZLAHHWMLIIM-UHFFFAOYSA-N 387272 N-(5-(5- (5,5-dimethyl-4-oxo- 4,5-dihydroisoxazol-3- yl)-2- methylphenyl)pyrazin- 2-yl)-3,5- difluoroisonicotinamide::US10292981, Example 114 Interleukin-2 <100.0 US Patent 10.7270/Q2D50Q8B aid1798707 US10292981 Irlapati, NR; Deshmukh, GK; Karche, VP; Jachak, SM; Sinha, N; Palle, VP; Kamboj, RK LUPIN LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387272 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387272&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 67515995 404856387 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 773715 CNc1ccc(cc1-c1ccc(NC(=O)c2c(F)cccc2F)cc1)C1=NOC(C)(C)C1=O InChI=1S/C25H21F2N3O3/c1-25(2)23(31)22(30-33-25)15-9-12-20(28-3)17(13-15)14-7-10-16(11-8-14)29-24(32)21-18(26)5-4-6-19(21)27/h4-13,28H,1-3H3,(H,29,32) LDGXRCFIEHUTCC-UHFFFAOYSA-N 387273 US10292981, Example 135 Interleukin-2 <100.0 US Patent 10.7270/Q2D50Q8B aid1798707 US10292981 Irlapati, NR; Deshmukh, GK; Karche, VP; Jachak, SM; Sinha, N; Palle, VP; Kamboj, RK LUPIN LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387273 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387273&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 67515392 404856388 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 773716 CCc1ccc(cc1-c1ccc(s1)C(=O)Nc1c(F)cccc1F)C1=NOC(C)(C)C1=O InChI=1S/C24H20F2N2O3S/c1-4-13-8-9-14(20-22(29)24(2,3)31-28-20)12-15(13)18-10-11-19(32-18)23(30)27-21-16(25)6-5-7-17(21)26/h5-12H,4H2,1-3H3,(H,27,30) KZOWQKXJSZKILX-UHFFFAOYSA-N 387274 N-(2,6- Difluorophenyl)-5-(5- (5,5-dimethyl-4-oxo- 4,5-dihydroisoxazol- 3-yl)-2-ethyl- phenyl)thiophene- 2-carboxamide ::US10292981, Example 157 Interleukin-2 <100.0 US Patent 10.7270/Q2D50Q8B aid1798707 US10292981 Irlapati, NR; Deshmukh, GK; Karche, VP; Jachak, SM; Sinha, N; Palle, VP; Kamboj, RK LUPIN LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387274 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387274&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 67514882 404856389 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 773717 CCc1ccc(cc1-c1ccc(s1)C(=O)Nc1ccncc1C)C1=NOC(C)(C)C1=O InChI=1S/C24H23N3O3S/c1-5-15-6-7-16(21-22(28)24(3,4)30-27-21)12-17(15)19-8-9-20(31-19)23(29)26-18-10-11-25-13-14(18)2/h6-13H,5H2,1-4H3,(H,25,26,29) BPEWWUFHHJJALF-UHFFFAOYSA-N 387276 5-(5- (5,5-Dimethyl-4-oxo- 4,5-dihydroisoxazol- 3-yl)-2-ethylphenyl)- N-(3-methylpyridin- 4-yl)thiophene-2- carboxamide ::US10292981, Example 158 Interleukin-2 <100.0 US Patent 10.7270/Q2D50Q8B aid1798707 US10292981 Irlapati, NR; Deshmukh, GK; Karche, VP; Jachak, SM; Sinha, N; Palle, VP; Kamboj, RK LUPIN LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387276 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387276&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 67515850 404856391 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 773718 COc1ccc(cc1-c1ccc(s1)C(=O)Nc1c(F)cccc1F)C1=NOC(C)(C)C1=O InChI=1S/C23H18F2N2O4S/c1-23(2)21(28)19(27-31-23)12-7-8-16(30-3)13(11-12)17-9-10-18(32-17)22(29)26-20-14(24)5-4-6-15(20)25/h4-11H,1-3H3,(H,26,29) ZAKLURTYMKCKHA-UHFFFAOYSA-N 387277 N-(2,6- Difluorophenyl)-5-(5- (5,5-dimethyl-4-oxo- 4,5-dihydroisoxazol- 3-yl)-2-methoxy- phenyl)thiophene- 2-carboxamide ::US10292981, Example 160 Interleukin-2 <100.0 US Patent 10.7270/Q2D50Q8B aid1798707 US10292981 Irlapati, NR; Deshmukh, GK; Karche, VP; Jachak, SM; Sinha, N; Palle, VP; Kamboj, RK LUPIN LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387277 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387277&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 67515433 404856392 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 773719 CCc1ccc(cc1-c1ccc(s1)C(=O)Nc1c(F)cccc1F)-c1nn(C)c(=O)o1 InChI=1S/C22H17F2N3O3S/c1-3-12-7-8-13(21-26-27(2)22(29)30-21)11-14(12)17-9-10-18(31-17)20(28)25-19-15(23)5-4-6-16(19)24/h4-11H,3H2,1-2H3,(H,25,28) OOGAUNBWNNRQGA-UHFFFAOYSA-N 387278 N-(2,6- Difluorophenyl)-5-(2- ethyl-5-(4-methyl-5- oxo-4,5-dihydro- 1,3,4-oxadiazol-2- yl)phenyl)thiophene- 2-carboxamide::US10292981, Example 171 Interleukin-2 <100.0 US Patent 10.7270/Q2D50Q8B aid1798707 US10292981 Irlapati, NR; Deshmukh, GK; Karche, VP; Jachak, SM; Sinha, N; Palle, VP; Kamboj, RK LUPIN LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387278 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387278&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 57331142 404856393 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 773720 Cn1nc(oc1=O)-c1ccc(OC(F)F)c(c1)-c1ccc(s1)C(=O)Nc1c(F)cccc1F InChI=1S/C21H13F4N3O4S/c1-28-21(30)32-19(27-28)10-5-6-14(31-20(24)25)11(9-10)15-7-8-16(33-15)18(29)26-17-12(22)3-2-4-13(17)23/h2-9,20H,1H3,(H,26,29) DXERDVIJRMRUCB-UHFFFAOYSA-N 387279 5-(2- (Difluoromethoxy)-5- (4-methyl-5-oxo-4,5- dihydro-1,3,4- oxadiazol-2- yl)phenyl)-N-(2,6- difluorophenyl) thiophene-2- carboxamide ::US10292981, Example 173 Interleukin-2 <100.0 US Patent 10.7270/Q2D50Q8B aid1798707 US10292981 Irlapati, NR; Deshmukh, GK; Karche, VP; Jachak, SM; Sinha, N; Palle, VP; Kamboj, RK LUPIN LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387279&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 57331144 404856394 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 773721 Cc1c(cccc1-c1nn(C)c(=O)o1)-c1ccc(s1)C(=O)Nc1c(F)cccc1F InChI=1S/C21H15F2N3O3S/c1-11-12(5-3-6-13(11)20-25-26(2)21(28)29-20)16-9-10-17(30-16)19(27)24-18-14(22)7-4-8-15(18)23/h3-10H,1-2H3,(H,24,27) RAZCHIWVZLUOQN-UHFFFAOYSA-N 387280 N-(2,6- Difluorophenyl)-5-(2- methyl-3-(4-methyl- 5-oxo-4,5-dihydro- 1,3,4-oxadiazol-2- yl)phenyl)thiophene- 2-carboxamide::US10292981, Example 176 Interleukin-2 <100.0 US Patent 10.7270/Q2D50Q8B aid1798707 US10292981 Irlapati, NR; Deshmukh, GK; Karche, VP; Jachak, SM; Sinha, N; Palle, VP; Kamboj, RK LUPIN LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387280 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387280&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 57330266 404856395 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 773722 Cc1ccc(cc1-c1ccc(NC(=O)c2c(F)cccc2F)nc1)C1=NOC(C)(C)C1=O InChI=1S/C24H19F2N3O3/c1-13-7-8-14(21-22(30)24(2,3)32-29-21)11-16(13)15-9-10-19(27-12-15)28-23(31)20-17(25)5-4-6-18(20)26/h4-12H,1-3H3,(H,27,28,31) BBFUAFQFQUCONY-UHFFFAOYSA-N 387281 N-(5-(5- (5,5-Dimethyl-4-oxo- 4,5-dihydroisoxazol- 3-yl)-2- methylphenyl)pyridin- 2-yl)-2,6- difluorobenzamide ::US10292981, Example 4 Interleukin-2 550 US Patent 10.7270/Q2D50Q8B aid1798707 US10292981 Irlapati, NR; Deshmukh, GK; Karche, VP; Jachak, SM; Sinha, N; Palle, VP; Kamboj, RK LUPIN LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387281&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 57330319 404856396 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 773723 CCc1ccc(cc1-c1ccc(NC(=O)c2c(F)cccc2F)cn1)C1=NOC(C)(C)C1=O InChI=1S/C25H21F2N3O3/c1-4-14-8-9-15(22-23(31)25(2,3)33-30-22)12-17(14)20-11-10-16(13-28-20)29-24(32)21-18(26)6-5-7-19(21)27/h5-13H,4H2,1-3H3,(H,29,32) AXZKCIIGEACCEC-UHFFFAOYSA-N 387282 N-(6-(5- (5,5-dimethyl-4-oxo- 4,5-dihydroisoxazol- 3-yl)-2- ethylphenyl)pyridin- 3-yl)-2,6- difluorobenzamide::US10292981, Example 7 Interleukin-2 550 US Patent 10.7270/Q2D50Q8B aid1798707 US10292981 Irlapati, NR; Deshmukh, GK; Karche, VP; Jachak, SM; Sinha, N; Palle, VP; Kamboj, RK LUPIN LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387282 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387282&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 57330321 404856397 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 773724 CC(C)c1ccc(cc1-c1cnc(NC(=O)c2c(F)cccc2F)cn1)C1=NOC(C)(C)C1=O InChI=1S/C25H22F2N4O3/c1-13(2)15-9-8-14(22-23(32)25(3,4)34-31-22)10-16(15)19-11-29-20(12-28-19)30-24(33)21-17(26)6-5-7-18(21)27/h5-13H,1-4H3,(H,29,30,33) RTCKXTOTTYWPLF-UHFFFAOYSA-N 387283 N-(5-(5- (5,5-dimethyl-4-oxo- 4,5-dihydroisoxazol- 3-yl)-2- isopropylphenyl)pyrazin- 2-yl)-2,6- difluorobenzamide::US10292981, Example 8 Interleukin-2 550 US Patent 10.7270/Q2D50Q8B aid1798707 US10292981 Irlapati, NR; Deshmukh, GK; Karche, VP; Jachak, SM; Sinha, N; Palle, VP; Kamboj, RK LUPIN LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387283&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 67515311 404856398 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 773725 CC1(C)ON=C(C1=O)c1ccc(Cl)c(c1)-c1ccc(NC(=O)c2c(F)cccc2F)cc1 InChI=1S/C24H17ClF2N2O3/c1-24(2)22(30)21(29-32-24)14-8-11-17(25)16(12-14)13-6-9-15(10-7-13)28-23(31)20-18(26)4-3-5-19(20)27/h3-12H,1-2H3,(H,28,31) VPNVXPWEPKFNHD-UHFFFAOYSA-N 387284 N-(2′- chloro-5′-(5,5- dimethyl-4-oxo-4,5- dihydroisoxazol-3- yl)-[1,1′-biphenyl]-4- yl)-2,6- difluorobenzamide::US10292981, Example 11 Interleukin-2 550 US Patent 10.7270/Q2D50Q8B aid1798707 US10292981 Irlapati, NR; Deshmukh, GK; Karche, VP; Jachak, SM; Sinha, N; Palle, VP; Kamboj, RK LUPIN LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387284&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 57330380 404856399 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 773726 COc1ccc(cc1-c1ccc(NC(=O)c2c(F)cccc2F)cn1)C1=NOC(C)(C)C1=O InChI=1S/C24H19F2N3O4/c1-24(2)22(30)21(29-33-24)13-7-10-19(32-3)15(11-13)18-9-8-14(12-27-18)28-23(31)20-16(25)5-4-6-17(20)26/h4-12H,1-3H3,(H,28,31) DZMUSTHWHKLETA-UHFFFAOYSA-N 387285 N-(6-(5- (5,5-dimethyl-4-oxo- 4,5-dihydroisoxazol- 3-yl)-2- methoxyphenyl)pyridin- 3-yl)-2,6- difluorobenzamide::US10292981, Example 18 Interleukin-2 550 US Patent 10.7270/Q2D50Q8B aid1798707 US10292981 Irlapati, NR; Deshmukh, GK; Karche, VP; Jachak, SM; Sinha, N; Palle, VP; Kamboj, RK LUPIN LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387285&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 67515792 404856400 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 773727 COC1C(=NOC1(C)C)c1ccc(C)c(c1)-c1cnc(NC(=O)c2c(F)cccc2F)cn1 InChI=1S/C24H22F2N4O3/c1-13-8-9-14(21-22(32-4)24(2,3)33-30-21)10-15(13)18-11-28-19(12-27-18)29-23(31)20-16(25)6-5-7-17(20)26/h5-12,22H,1-4H3,(H,28,29,31) RWYVQTQCSDNUNW-UHFFFAOYSA-N 387286 2,6- difluoro-N-(5-(5-(4- methoxy-5,5- dimethyl-4,5- dihydroisoxazol-3- yl)-2- methylphenyl)pyrazin- 2-yl)benzamide::US10292981, Example 23 Interleukin-2 550 US Patent 10.7270/Q2D50Q8B aid1798707 US10292981 Irlapati, NR; Deshmukh, GK; Karche, VP; Jachak, SM; Sinha, N; Palle, VP; Kamboj, RK LUPIN LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387286&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 57330440 404856401 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 773728 COC1C(=NOC1(C)C)c1ccc(C)c(c1)-c1ccc(NC(=O)c2c(F)cccc2F)cc1 InChI=1S/C26H24F2N2O3/c1-15-8-9-17(23-24(32-4)26(2,3)33-30-23)14-19(15)16-10-12-18(13-11-16)29-25(31)22-20(27)6-5-7-21(22)28/h5-14,24H,1-4H3,(H,29,31) OVAPXSYEFRBAPF-UHFFFAOYSA-N 387287 2,6- Difluoro-N-(5′-(4- methoxy-5,5- dimethyl-4,5- dihydroisoxazol-3- yl)-2′-methyl-[1,1′- biphenyl]-4- yl)benzamide::US10292981, Example 24 Interleukin-2 550 US Patent 10.7270/Q2D50Q8B aid1798707 US10292981 Irlapati, NR; Deshmukh, GK; Karche, VP; Jachak, SM; Sinha, N; Palle, VP; Kamboj, RK LUPIN LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387287&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 57330441 404856402 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 773729 COc1c(cccc1-c1ccc(NC(=O)c2c(F)cccc2F)cc1)C1=NOC(C)(C)C1=O InChI=1S/C25H20F2N2O4/c1-25(2)23(30)21(29-33-25)17-7-4-6-16(22(17)32-3)14-10-12-15(13-11-14)28-24(31)20-18(26)8-5-9-19(20)27/h4-13H,1-3H3,(H,28,31) ATABWEVAFCJIRP-UHFFFAOYSA-N 387288 N-(3′- (5,5-Dimethyl-4-oxo- 4,5-dihydroisoxazol- 3-yl)-2′-methoxy- [1,1′-bipheny;]-4-yl)- 2,6- difluorobenzamide::US10292981, Example 31 Interleukin-2 550 US Patent 10.7270/Q2D50Q8B aid1798707 US10292981 Irlapati, NR; Deshmukh, GK; Karche, VP; Jachak, SM; Sinha, N; Palle, VP; Kamboj, RK LUPIN LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387288 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387288&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 67515701 404856403 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 773730 Cc1ccc(cc1-c1cnc(NC(=O)c2cccnc2C)cn1)C1=NOC(C)(C)C1=O InChI=1S/C23H21N5O3/c1-13-7-8-15(20-21(29)23(3,4)31-28-20)10-17(13)18-11-26-19(12-25-18)27-22(30)16-6-5-9-24-14(16)2/h5-12H,1-4H3,(H,26,27,30) YICKYTIMRQDPKA-UHFFFAOYSA-N 387289 N-(5-(5- (5,5-dimethyl-4-oxo- 4,5-dihydroisoxazol-3- yl)-2- methylphenyl)pyrazin- 2-yl)-2- methylnicotinamide::US10292981, Example 113 Interleukin-2 550 US Patent 10.7270/Q2D50Q8B aid1798707 US10292981 Irlapati, NR; Deshmukh, GK; Karche, VP; Jachak, SM; Sinha, N; Palle, VP; Kamboj, RK LUPIN LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387289&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 57330779 404856404 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 773731 Cc1ccc(cc1-c1cnc(NC(=O)c2c(F)cccc2F)cn1)C1=NOC(C)(C)C1 InChI=1S/C23H20F2N4O2/c1-13-7-8-14(18-10-23(2,3)31-29-18)9-15(13)19-11-27-20(12-26-19)28-22(30)21-16(24)5-4-6-17(21)25/h4-9,11-12H,10H2,1-3H3,(H,27,28,30) DREFJQDUVPJVKI-UHFFFAOYSA-N 387290 N-(5- (5,5-Dimethyl-4,5- dihydroisoxazol-3- yl)-2- methylphenyl)pyrazin- 2-yl)-2,6- difluorobenzamide::US10292981, Example 53 Interleukin-2 550 US Patent 10.7270/Q2D50Q8B aid1798707 US10292981 Irlapati, NR; Deshmukh, GK; Karche, VP; Jachak, SM; Sinha, N; Palle, VP; Kamboj, RK LUPIN LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387290 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387290&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89771956 404856405 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 773732 Cc1ccc(cc1-c1ccc(NC(=O)c2c(F)cccc2F)cc1)C1=NOC2(CCCCC2)C1=O InChI=1S/C28H24F2N2O3/c1-17-8-9-19(25-26(33)28(35-32-25)14-3-2-4-15-28)16-21(17)18-10-12-20(13-11-18)31-27(34)24-22(29)6-5-7-23(24)30/h5-13,16H,2-4,14-15H2,1H3,(H,31,34) CYDWCBHDCLFFMC-UHFFFAOYSA-N 387291 2,6- Difluoro-N-(2′- methyl-5′-(4-oxo-1- oxa-2- azaspiro[4.5]dec-2- en-3-yl)-[1,1′- biphenyl]-4- yl)benzamide::US10292981, Example 58 Interleukin-2 550 US Patent 10.7270/Q2D50Q8B aid1798707 US10292981 Irlapati, NR; Deshmukh, GK; Karche, VP; Jachak, SM; Sinha, N; Palle, VP; Kamboj, RK LUPIN LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387291 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387291&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89763854 404856406 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 773733 Cc1ccc(cc1-c1ccc(NC(=O)c2c(F)cccc2F)cc1)C1=NC(C)(C)CO1 InChI=1S/C25H22F2N2O2/c1-15-7-8-17(24-29-25(2,3)14-31-24)13-19(15)16-9-11-18(12-10-16)28-23(30)22-20(26)5-4-6-21(22)27/h4-13H,14H2,1-3H3,(H,28,30) AKWLXQBLZVKWTA-UHFFFAOYSA-N 387292 N-(5′- (4,4-dimethyl-4,5- dihydrooxazol-2-yl)- 2′-methyl-[1,1′- biphenyl]-4-yl)-2,6- difluorobenzamide::US10292981, Example 61 Interleukin-2 550 US Patent 10.7270/Q2D50Q8B aid1798707 US10292981 Irlapati, NR; Deshmukh, GK; Karche, VP; Jachak, SM; Sinha, N; Palle, VP; Kamboj, RK LUPIN LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387292 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387292&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 67515666 404856407 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 773734 Cc1ccc(cc1-c1cnc(NC(=O)c2cc(F)ccc2F)cn1)C1=NOC(C)(C)C1=O InChI=1S/C23H18F2N4O3/c1-12-4-5-13(20-21(30)23(2,3)32-29-20)8-15(12)18-10-27-19(11-26-18)28-22(31)16-9-14(24)6-7-17(16)25/h4-11H,1-3H3,(H,27,28,31) LIXKWKSOEHBXRI-UHFFFAOYSA-N 387293 N-(5-(5- (5,5-Dimethyl-4-oxo- 4,5-dihydroisoxazol- 3-yl)-2- methylphenyl)pyrazine- 2-yl)-2,5- difluorobenzamide::US10292981, Example 67 Interleukin-2 550 US Patent 10.7270/Q2D50Q8B aid1798707 US10292981 Irlapati, NR; Deshmukh, GK; Karche, VP; Jachak, SM; Sinha, N; Palle, VP; Kamboj, RK LUPIN LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387293 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387293&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 69675936 404856408 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 773735 Cc1ccc(cc1-c1cnc(NC(=O)c2ccccc2Cl)cn1)C1=NOC(C)(C)C1=O InChI=1S/C23H19ClN4O3/c1-13-8-9-14(20-21(29)23(2,3)31-28-20)10-16(13)18-11-26-19(12-25-18)27-22(30)15-6-4-5-7-17(15)24/h4-12H,1-3H3,(H,26,27,30) GDPDBPBRFMYPNO-UHFFFAOYSA-N 387294 US10292981, Example 78 Interleukin-2 550 US Patent 10.7270/Q2D50Q8B aid1798707 US10292981 Irlapati, NR; Deshmukh, GK; Karche, VP; Jachak, SM; Sinha, N; Palle, VP; Kamboj, RK LUPIN LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387294&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 57330623 404856409 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 773736 Cc1ccc(cc1-c1cnc(NC(=O)c2c(Cl)cncc2Cl)cn1)C1=NOC(C)(C)C1=O InChI=1S/C22H17Cl2N5O3/c1-11-4-5-12(19-20(30)22(2,3)32-29-19)6-13(11)16-9-27-17(10-26-16)28-21(31)18-14(23)7-25-8-15(18)24/h4-10H,1-3H3,(H,27,28,31) HLZWGPWIRVRBGR-UHFFFAOYSA-N 387295 3,5- Dichloro-N-(5-(5-(5,5- dimethyl-4-oxo-4,5- dihydroisoxazol-3- yl)-2- methylphenyl)pyrazin- 2-yl)isonicotinamide::US10292981, Example 103 Interleukin-2 550 US Patent 10.7270/Q2D50Q8B aid1798707 US10292981 Irlapati, NR; Deshmukh, GK; Karche, VP; Jachak, SM; Sinha, N; Palle, VP; Kamboj, RK LUPIN LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387295 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387295&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 57330681 404856410 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 773737 Cc1ccc(cc1-c1cnc(NC(=O)c2ccncc2F)cn1)C1=NOC(C)(C)C1=O InChI=1S/C22H18FN5O3/c1-12-4-5-13(19-20(29)22(2,3)31-28-19)8-15(12)17-10-26-18(11-25-17)27-21(30)14-6-7-24-9-16(14)23/h4-11H,1-3H3,(H,26,27,30) OFWLFXZYHKJIML-UHFFFAOYSA-N 387296 N-(5-(5- (5,5-dimethyl-4-oxo- 4,5-dihydroisoxazol- 3-yl)-2- methylphenyl)pyrazin- 2-yl)-3- fluoroisonicotinamide::US10292981, Example 107 Interleukin-2 550 US Patent 10.7270/Q2D50Q8B aid1798707 US10292981 Irlapati, NR; Deshmukh, GK; Karche, VP; Jachak, SM; Sinha, N; Palle, VP; Kamboj, RK LUPIN LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387296 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387296&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 57330733 404856411 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 773738 Cc1ccc(cc1-c1cnc(cn1)C(=O)Nc1c(F)cccc1F)C1=NOC(C)(C)C1=O InChI=1S/C23H18F2N4O3/c1-12-7-8-13(19-21(30)23(2,3)32-29-19)9-14(12)17-10-27-18(11-26-17)22(31)28-20-15(24)5-4-6-16(20)25/h4-11H,1-3H3,(H,28,31) KDVVIMMGQHFHBT-UHFFFAOYSA-N 387297 US10292981, Example 121 Interleukin-2 550 US Patent 10.7270/Q2D50Q8B aid1798707 US10292981 Irlapati, NR; Deshmukh, GK; Karche, VP; Jachak, SM; Sinha, N; Palle, VP; Kamboj, RK LUPIN LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387297&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 57330782 404856412 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 773739 CC(C)Oc1ccc(cc1-c1cnc(NC(=O)c2c(F)cccc2F)cn1)C1=NOC(C)(C)C1=O InChI=1S/C25H22F2N4O4/c1-13(2)34-19-9-8-14(22-23(32)25(3,4)35-31-22)10-15(19)18-11-29-20(12-28-18)30-24(33)21-16(26)6-5-7-17(21)27/h5-13H,1-4H3,(H,29,30,33) JQOXBCMPDSKKFV-UHFFFAOYSA-N 387299 N-(5-(5- (5,5-dimethyl-4-oxo- 4,5-dihydroisoxazol-3- yl)-2-isopropoxy- phenyl)pyrazin- 2-yl)-2,6- difluorobenzamide ::US10292981, Example 126 Interleukin-2 550 US Patent 10.7270/Q2D50Q8B aid1798707 US10292981 Irlapati, NR; Deshmukh, GK; Karche, VP; Jachak, SM; Sinha, N; Palle, VP; Kamboj, RK LUPIN LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387299 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387299&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 57330831 404856414 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 773740 CC1(C)ON=C(C1=O)c1ccc(OCC=C)c(c1)-c1ccc(NC(=O)c2c(F)cccc2F)cc1 InChI=1S/C27H22F2N2O4/c1-4-14-34-22-13-10-17(24-25(32)27(2,3)35-31-24)15-19(22)16-8-11-18(12-9-16)30-26(33)23-20(28)6-5-7-21(23)29/h4-13,15H,1,14H2,2-3H3,(H,30,33) CWKALAKQGXNNIP-UHFFFAOYSA-N 387301 N-(2′- (allyloxy)-5′-(5,5- dimethyl-4-oxo-4,5- dihydroisoxazol-3-yl)- [1,1′-biphenyl]-4-yl)- 2,6-difluorobenzamide ::US10292981, Example 132 Interleukin-2 550 US Patent 10.7270/Q2D50Q8B aid1798707 US10292981 Irlapati, NR; Deshmukh, GK; Karche, VP; Jachak, SM; Sinha, N; Palle, VP; Kamboj, RK LUPIN LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387301 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387301&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 57330834 404856416 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 773741 CN(C)c1ccc(cc1-c1ccc(NC(=O)c2c(F)cccc2F)cc1)C1=NOC(C)(C)C1=O InChI=1S/C26H23F2N3O3/c1-26(2)24(32)23(30-34-26)16-10-13-21(31(3)4)18(14-16)15-8-11-17(12-9-15)29-25(33)22-19(27)6-5-7-20(22)28/h5-14H,1-4H3,(H,29,33) SUODEOOJCNLTFN-UHFFFAOYSA-N 387306 US10292981, Example 136 Interleukin-2 550 US Patent 10.7270/Q2D50Q8B aid1798707 US10292981 Irlapati, NR; Deshmukh, GK; Karche, VP; Jachak, SM; Sinha, N; Palle, VP; Kamboj, RK LUPIN LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387306 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387306&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 57330891 404856421 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 773742 Cc1c(cccc1-c1cnc(NC(=O)C2CCc3ccccc3C2)cn1)-c1nn(C)c(=O)o1 InChI=1S/C25H23N5O3/c1-15-19(8-5-9-20(15)24-29-30(2)25(32)33-24)21-13-27-22(14-26-21)28-23(31)18-11-10-16-6-3-4-7-17(16)12-18/h3-9,13-14,18H,10-12H2,1-2H3,(H,27,28,31) UHSLDXRDGJQJQF-UHFFFAOYSA-N 387307 US10292981, Example 138 Interleukin-2 550 US Patent 10.7270/Q2D50Q8B aid1798707 US10292981 Irlapati, NR; Deshmukh, GK; Karche, VP; Jachak, SM; Sinha, N; Palle, VP; Kamboj, RK LUPIN LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387307 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387307&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 57330892 404856422 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 773743 CC(C)(C)c1ccc(cc1-c1ccc(NC(=O)c2c(F)cccc2F)cc1)C1=NOC(C)(C)C1=O InChI=1S/C28H26F2N2O3/c1-27(2,3)20-14-11-17(24-25(33)28(4,5)35-32-24)15-19(20)16-9-12-18(13-10-16)31-26(34)23-21(29)7-6-8-22(23)30/h6-15H,1-5H3,(H,31,34) BGMDYWZEMGOCBS-UHFFFAOYSA-N 387308 N-(2′- (tert-butyl)-5′-(5,5- dimethyl-4-oxo-4,5- dihydroisoxazol-3- yl)-[1,1′-biphenyl]-4- yl)-2,6- difluorobenzamide::US10292981, Example 10 Interleukin-2 >1000 US Patent 10.7270/Q2D50Q8B aid1798707 US10292981 Irlapati, NR; Deshmukh, GK; Karche, VP; Jachak, SM; Sinha, N; Palle, VP; Kamboj, RK LUPIN LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387308 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387308&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 57330379 404856423 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 773744 COc1ccc(cc1-c1ccc(NC(=O)c2c(F)cccc2F)nc1)C1=NOC(C)(C)C1=O InChI=1S/C24H19F2N3O4/c1-24(2)22(30)21(29-33-24)13-7-9-18(32-3)15(11-13)14-8-10-19(27-12-14)28-23(31)20-16(25)5-4-6-17(20)26/h4-12H,1-3H3,(H,27,28,31) SZQXVNIKXBPIQX-UHFFFAOYSA-N 387309 N-(5-(5- (5,5-dimethyl-4-oxo- 4,5-dihydroisoxazol- 3-yl)-2- methoxyphenyl)pyridin- 2-yl)-2,6- difluorobenzamide::US10292981, Example 17 Interleukin-2 >1000 US Patent 10.7270/Q2D50Q8B aid1798707 US10292981 Irlapati, NR; Deshmukh, GK; Karche, VP; Jachak, SM; Sinha, N; Palle, VP; Kamboj, RK LUPIN LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387309&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 57330383 404856424 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 773745 Cc1ccc(cc1-c1cnc(NC(=O)c2ccc(F)cc2)cn1)C1=NOC(C)(C)C1=O InChI=1S/C23H19FN4O3/c1-13-4-5-15(20-21(29)23(2,3)31-28-20)10-17(13)18-11-26-19(12-25-18)27-22(30)14-6-8-16(24)9-7-14/h4-12H,1-3H3,(H,26,27,30) KCEQOYUWLJMBQM-UHFFFAOYSA-N 387310 N-(5-(5- (5,5-Dimethyl-4-oxo- 4,5-dihydroisoxazol- 3-yl)-2- methylphenyl)pyrazine- 2-yl)-4- fluorobenzamide::US10292981, Example 69 Interleukin-2 >1000 US Patent 10.7270/Q2D50Q8B aid1798707 US10292981 Irlapati, NR; Deshmukh, GK; Karche, VP; Jachak, SM; Sinha, N; Palle, VP; Kamboj, RK LUPIN LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387310 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387310&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 67515485 404856425 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 773746 Cc1ccc(cc1-c1ccc(NC(=O)c2c(F)cccc2F)cc1)C1=NOC(CO)(CCO)C1 InChI=1S/C26H24F2N2O4/c1-16-5-6-18(23-14-26(15-32,11-12-31)34-30-23)13-20(16)17-7-9-19(10-8-17)29-25(33)24-21(27)3-2-4-22(24)28/h2-10,13,31-32H,11-12,14-15H2,1H3,(H,29,33) LXKNMMAJVDVTNY-UHFFFAOYSA-N 387312 2,6- Difluoro-N-(5′-(5-(2- hydroxyethyl)-5- (hydroxymethyl)-4,5- dihydroisoxazol-3-yl)- 2′-methyl-[1,1′- biphenyl]-4- yl)benzamide::US10292981, Example 145 Interleukin-2 >1000 US Patent 10.7270/Q2D50Q8B aid1798707 US10292981 Irlapati, NR; Deshmukh, GK; Karche, VP; Jachak, SM; Sinha, N; Palle, VP; Kamboj, RK LUPIN LIMITED http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387312 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387312&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 57330954 404856427 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822399 Cc1ccncc1C(=O)Nc1cnc(cn1)-c1cc(ccc1Cl)-c1cn[nH]c1 InChI=1S/C20H15ClN6O/c1-12-4-5-22-9-16(12)20(28)27-19-11-23-18(10-24-19)15-6-13(2-3-17(15)21)14-7-25-26-8-14/h2-11H,1H3,(H,25,26)(H,24,27,28) PVIDYZKVULTDKO-UHFFFAOYSA-N 412368 N-(5-(2-chloro-5-(1H-pyrazol-4- yl)phenyl)pyrazin-2-yl)-4- methylnicotinamide::US10399967, Compound 1 Interleukin-2 34.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412368 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412368&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822400 CCOc1ccc(cc1-c1cnc(NC(=O)c2cnccc2C)cn1)-c1cnn(C)c1 InChI=1S/C23H22N6O2/c1-4-31-21-6-5-16(17-10-27-29(3)14-17)9-18(21)20-12-26-22(13-25-20)28-23(30)19-11-24-8-7-15(19)2/h5-14H,4H2,1-3H3,(H,26,28,30) FUGRMLLPNYCFLH-UHFFFAOYSA-N 412372 N-(5-(2-ethoxy-5-(1-methyl-1H- pyrazol-4-yl)phenyl)pyrazin-2-yl)-4- methylnicotinamide::US10399967, Compound 2 Interleukin-2 51.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412372 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412372&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822401 Cc1nc(cs1)-c1ccc(Cl)c(c1)-c1cnc(NC(=O)c2cnccc2C)cn1 InChI=1S/C21H16ClN5OS/c1-12-5-6-23-8-16(12)21(28)27-20-10-24-18(9-25-20)15-7-14(3-4-17(15)22)19-11-29-13(2)26-19/h3-11H,1-2H3,(H,25,27,28) IPZIGLBNGFFGLY-UHFFFAOYSA-N 412373 N-(5-(2-chloro-5-(2-methylthiazol-4- yl)phenyl)pyrazin-2-yl)-4- methylnicotinamide::US10399967, Compound 3 Interleukin-2 60.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412373 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412373&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822402 C\C=C(\c1ccc(Br)cc1)c1ccc(NC(=O)c2cncc(F)c2C)cc1C InChI=1S/C23H20BrFN2O/c1-4-19(16-5-7-17(24)8-6-16)20-10-9-18(11-14(20)2)27-23(28)21-12-26-13-22(25)15(21)3/h4-13H,1-3H3,(H,27,28)/b19-4- MKECSIZJNSMZPT-PVOVUMCXSA-N 412374 (Z)-N-(4-(1-(4-bromophenyl)prop-1- en-1-yl)-3-methylphenyl)-5-fluoro-4- methylnicotinamide::US10399967, Compound 4 Interleukin-2 50.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412374 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412374&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822403 Cc1cc(NC(=O)c2cncc(F)c2C)ccc1C(=C)c1ccc(Br)cc1 InChI=1S/C22H18BrFN2O/c1-13-10-18(26-22(27)20-11-25-12-21(24)15(20)3)8-9-19(13)14(2)16-4-6-17(23)7-5-16/h4-12H,2H2,1,3H3,(H,26,27) XVYYZEWDSGNCGI-UHFFFAOYSA-N 412375 N-(4-(1-(4-bromophenyl)vinyl)-3- methylphenyl)-5-fluoro-4- methylnicotinamide::US10399967, Compound 5 Interleukin-2 202 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412375 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412375&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822404 COc1ccc(cc1-c1cnc(NC(=O)c2cncc(F)c2C)cn1)-c1cnn(C)c1 InChI=1S/C22H19FN6O2/c1-13-17(8-24-9-18(13)23)22(30)28-21-11-25-19(10-26-21)16-6-14(4-5-20(16)31-3)15-7-27-29(2)12-15/h4-12H,1-3H3,(H,26,28,30) FNZBNHCFCGJOJX-UHFFFAOYSA-N 412376 5-fluoro-N-(5-(2-methoxy-5-(1- methyl-1H-pyrazol-4- yl)phenyl)pyrazin-2-yl)-4- methylnicotinamide::US10399967, Compound 6 Interleukin-2 20.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412376 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412376&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822405 CCc1ccc(cc1-c1ccc(NC(=O)c2cnccc2C)nc1)-c1cnn(C)c1 InChI=1S/C24H23N5O/c1-4-17-5-6-18(20-13-27-29(3)15-20)11-21(17)19-7-8-23(26-12-19)28-24(30)22-14-25-10-9-16(22)2/h5-15H,4H2,1-3H3,(H,26,28,30) ZDXWPSHDCYTWJJ-UHFFFAOYSA-N 412377 N-(5-(2-ethyl-5-(1-methyl-1H- pyrazol-4-yl)phenyl)pyridin-2-yl)-4- methylnicotinamide::US10399967, Compound 7 Interleukin-2 12.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412377 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412377&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822406 CCc1ccc(cc1-c1cnc(NC(=O)c2cnccc2C)cn1)-c1cnn(C)c1 InChI=1S/C23H22N6O/c1-4-16-5-6-17(18-10-27-29(3)14-18)9-19(16)21-12-26-22(13-25-21)28-23(30)20-11-24-8-7-15(20)2/h5-14H,4H2,1-3H3,(H,26,28,30) MEIKAEQFZADYSI-UHFFFAOYSA-N 412378 N-(5-(2-ethyl-5-(1-methyl-1H- pyrazol-4-yl)phenyl)pyrazin-2-yl)-4- methylnicotinamide::US10399967, Compound 8 Interleukin-2 25.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412378 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412378&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822407 Cc1ccncc1C(=O)Nc1ccc(cn1)-c1ccc(OC2CC2)cc1Cl InChI=1S/C21H18ClN3O2/c1-13-8-9-23-12-18(13)21(26)25-20-7-2-14(11-24-20)17-6-5-16(10-19(17)22)27-15-3-4-15/h2,5-12,15H,3-4H2,1H3,(H,24,25,26) ZIPSXWNBVRXBST-UHFFFAOYSA-N 412379 N-(5-(2-chloro-4- cyclopropoxyphenyl)pyridin-2-yl)-4- methylnicotinamide::US10399967, Compound 9 Interleukin-2 28.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412379 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412379&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822408 C\C=C(\c1ccc(Br)cc1)c1ccc(NC(=O)c2cnccc2C)nc1 InChI=1S/C21H18BrN3O/c1-3-18(15-4-7-17(22)8-5-15)16-6-9-20(24-12-16)25-21(26)19-13-23-11-10-14(19)2/h3-13H,1-2H3,(H,24,25,26)/b18-3- GOZMHJKUTPQVNH-ZUWFHJRGSA-N 412380 (Z)-N-(5-(1-(4-bromophenyl)prop-1- en-1-yl)pyridin-2-yl)-4- methylnicotinamide::US10399967, Compound 10 Interleukin-2 46.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412380 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412380&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822409 C\C=C(\c1ccc(cc1)-n1cnc(C)c1)c1ccc(NC(=O)c2cncc(F)c2C)nc1 InChI=1S/C25H22FN5O/c1-4-21(18-5-8-20(9-6-18)31-14-16(2)29-15-31)19-7-10-24(28-11-19)30-25(32)22-12-27-13-23(26)17(22)3/h4-15H,1-3H3,(H,28,30,32)/b21-4- JKVWENDNMAQCEP-IGLQUIOVSA-N 412381 (Z)-5-fluoro-4-methyl-N-(5-(1-(4-(4- methyl-1H-imidazol-1- yl)phenyl)prop-1-en-1-yl)pyridin-2- yl)nicotinamide::US10399967, Compound 11 Interleukin-2 58.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412381 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412381&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822410 C\C=C(\c1ccc(cc1)-c1cnn(C)c1)c1cnc(NC(=O)c2cnccc2C)cn1 InChI=1S/C24H22N6O/c1-4-20(18-7-5-17(6-8-18)19-11-28-30(3)15-19)22-13-27-23(14-26-22)29-24(31)21-12-25-10-9-16(21)2/h4-15H,1-3H3,(H,27,29,31)/b20-4- DBNKVJOEMMRRMO-YQLNASGTSA-N 412382 (Z)-4-methyl-N-(5-(1-(4-(1-methyl- 1H-pyrazol-4-yl)phenyl)prop-1-en-1- yl)pyrazin-2-yl)nicotinamide::US10399967, Compound 12 Interleukin-2 763 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412382 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412382&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822411 C\C=C(\c1ccc(cc1)-c1cncn1C)c1ccc(NC(=O)c2cncc(F)c2C)nc1 InChI=1S/C25H22FN5O/c1-4-20(17-5-7-18(8-6-17)23-14-28-15-31(23)3)19-9-10-24(29-11-19)30-25(32)21-12-27-13-22(26)16(21)2/h4-15H,1-3H3,(H,29,30,32)/b20-4- WJTRRWVUYMAHLT-YQLNASGTSA-N 412383 (Z)-5-fluoro-4-methyl-N-(5-(1-(4-(1- methyl-1H-imidazol-5- yl)phenyl)prop-1-en-1-yl)pyridin-2- yl)nicotinamide::US10399967, Compound 13 Interleukin-2 44.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412383 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412383&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822412 Cc1cnc(s1)-c1ccc(Cl)c(c1)-c1cnc(NC(=O)c2cnccc2C)cn1 InChI=1S/C21H16ClN5OS/c1-12-5-6-23-9-16(12)20(28)27-19-11-24-18(10-25-19)15-7-14(3-4-17(15)22)21-26-8-13(2)29-21/h3-11H,1-2H3,(H,25,27,28) DPEPYVKBAVEMEI-UHFFFAOYSA-N 412384 N-(5-(2-chloro-5-(5-methylthiazol-2- yl)phenyl)pyrazin-2-yl)-4- methylnicotinamide::US10399967, Compound 14 Interleukin-2 13.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412384 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412384&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822413 Cc1ccncc1C(=O)Nc1ccc(cn1)-c1cc(Nc2ncccc2F)ccc1Cl InChI=1S/C23H17ClFN5O/c1-14-8-10-26-13-18(14)23(31)30-21-7-4-15(12-28-21)17-11-16(5-6-19(17)24)29-22-20(25)3-2-9-27-22/h2-13H,1H3,(H,27,29)(H,28,30,31) RIZSMHIXKKLBPV-UHFFFAOYSA-N 412385 N-(5-(2-chloro-5-((3-fluoropyridin-2- yl)amino)phenyl)pyridin-2-yl)-4- methylnicotinamide::US10399967, Compound 15 Interleukin-2 104 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412385 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412385&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822414 Cc1ccncc1C(=O)Nc1cnc(cn1)-c1cc(Oc2ncccn2)ccc1Cl InChI=1S/C21H15ClN6O2/c1-13-5-8-23-10-16(13)20(29)28-19-12-26-18(11-27-19)15-9-14(3-4-17(15)22)30-21-24-6-2-7-25-21/h2-12H,1H3,(H,27,28,29) UMPHYOZCLQBPJM-UHFFFAOYSA-N 412386 N-(5-(2-chloro-5-(pyrimidin-2- yloxy)phenyl)pyrazin-2-yl)-4- methylnicotinamide::US10399967, Compound 16 Interleukin-2 46.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412386 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412386&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822415 Cc1ccncc1C(=O)Nc1ccc(cc1)-c1cc(ccc1Cl)C(F)(F)F InChI=1S/C20H14ClF3N2O/c1-12-8-9-25-11-17(12)19(27)26-15-5-2-13(3-6-15)16-10-14(20(22,23)24)4-7-18(16)21/h2-11H,1H3,(H,26,27) MDNIBTJFBWCLFR-UHFFFAOYSA-N 412387 N-(2'-chloro-5'-(trifluoromethyl)- [1,1'-biphenyl]-4-yl)-4- methylnicotinamide::US10399967, Compound 17 Interleukin-2 12.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412387 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412387&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822416 CO\N=C(\c1ccc(OC)cc1)c1ccc(NC(=O)c2cncc(F)c2C)nc1 InChI=1S/C21H19FN4O3/c1-13-17(11-23-12-18(13)22)21(27)25-19-9-6-15(10-24-19)20(26-29-3)14-4-7-16(28-2)8-5-14/h4-12H,1-3H3,(H,24,25,27)/b26-20- DNTAAFDAFFDBNO-QOMWVZHYSA-N 412388 (Z)-5-fluoro-N-(5-((methoxyimino)(4- methoxyphenyl)methyl)pyridin-2- yl)-4-methylnicotinamide::US10399967, Compound 18 Interleukin-2 52.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412388 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412388&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822417 CC(C)Oc1ccc(cc1-c1cnc(NC(=O)c2cnccc2C)cn1)-c1cnn(C)c1 InChI=1S/C24H24N6O2/c1-15(2)32-22-6-5-17(18-10-28-30(4)14-18)9-19(22)21-12-27-23(13-26-21)29-24(31)20-11-25-8-7-16(20)3/h5-15H,1-4H3,(H,27,29,31) XAIWJNYPKXKQAI-UHFFFAOYSA-N 412389 N-(5-(2-isopropoxy-5-(1-methyl-1H- pyrazol-4-yl)phenyl)pyrazin-2-yl)-4- methylnicotinamide::US10399967, Compound 19 Interleukin-2 79.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412389 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412389&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822418 Cc1ccncc1C(=O)Nc1ccc(cn1)-c1cc(OC2CC2)ncc1C InChI=1S/C21H20N4O2/c1-13-7-8-22-12-18(13)21(26)25-19-6-3-15(11-23-19)17-9-20(24-10-14(17)2)27-16-4-5-16/h3,6-12,16H,4-5H2,1-2H3,(H,23,25,26) VTYONLWKFMFCDE-UHFFFAOYSA-N 412390 N-(2'-cyclopropoxy-5'-methyl-[3,4'- bipyridin]-6-yl)-4- methylnicotinamide::US10399967, Compound 20 Interleukin-2 73.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412390&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822419 Cc1ccncc1C(=O)Nc1cnc(c(C)n1)-c1cccc(OC(F)(F)F)c1 InChI=1S/C19H15F3N4O2/c1-11-6-7-23-9-15(11)18(27)26-16-10-24-17(12(2)25-16)13-4-3-5-14(8-13)28-19(20,21)22/h3-10H,1-2H3,(H,25,26,27) FMNLRRCBGHCBSU-UHFFFAOYSA-N 412391 4-methyl-N-(6-methyl-5-(3- (trifluoromethoxy)phenyl)pyrazin-2- yl)nicotinamide::US10399967, Compound 21 Interleukin-2 1000 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412391&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822420 Cc1c(F)cncc1C(=O)Nc1cnc(cn1)-c1cc(ccc1OC(F)(F)F)-c1cnn(C)c1 InChI=1S/C22H16F4N6O2/c1-12-16(7-27-8-17(12)23)21(33)31-20-10-28-18(9-29-20)15-5-13(14-6-30-32(2)11-14)3-4-19(15)34-22(24,25)26/h3-11H,1-2H3,(H,29,31,33) PHDUBMDZGOHOPU-UHFFFAOYSA-N 412392 5-fluoro-4-methyl-N-(5-(5-(1-methyl- 1H-pyrazol-4-yl)-2- (trifluoromethoxy)phenyl)pyrazin-2- yl)nicotinamide::US10399967, Compound 22 Interleukin-2 9.00 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412392 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412392&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822421 Cc1c(F)cncc1C(=O)Nc1ccc(cn1)-c1cc(Oc2ncccn2)ccc1Cl InChI=1S/C22H15ClFN5O2/c1-13-17(11-25-12-19(13)24)21(30)29-20-6-3-14(10-28-20)16-9-15(4-5-18(16)23)31-22-26-7-2-8-27-22/h2-12H,1H3,(H,28,29,30) NPCATOYHZBQLOI-UHFFFAOYSA-N 412393 N-(5-(2-chloro-5-(pyrimidin-2- yloxy)phenyl)pyridin-2-yl)-5-fluoro- 4-methylnicotinamide::US10399967, Compound 23 Interleukin-2 46.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412393&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822422 Cc1ccncc1C(=O)Nc1cnc(cn1)-c1cc(ccc1Cl)-c1ccncc1F InChI=1S/C22H15ClFN5O/c1-13-4-6-25-9-17(13)22(30)29-21-12-27-20(11-28-21)16-8-14(2-3-18(16)23)15-5-7-26-10-19(15)24/h2-12H,1H3,(H,28,29,30) HWIFLIDFRFGQAR-UHFFFAOYSA-N 412394 N-(5-(2-chloro-5-(3-fluoropyridin-4- yl)phenyl)pyrazin-2-yl)-4- methylnicotinamide::US10399967, Compound 24 Interleukin-2 19.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412394&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822423 CO\N=C(/c1ccc(NC(=O)c2cncc(F)c2C)nc1)c1ccc(OC)cc1C InChI=1S/C22H21FN4O3/c1-13-9-16(29-3)6-7-17(13)21(27-30-4)15-5-8-20(25-10-15)26-22(28)18-11-24-12-19(23)14(18)2/h5-12H,1-4H3,(H,25,26,28)/b27-21+ XXUCSSCKAJHBSO-SZXQPVLSSA-N 412395 (Z)-5-fluoro-N-(5-((4-methoxy-2- methylphenyl)(methoxyimino)methyl) pyridin-2-yl)-4-methylnicotinamide::US10399967, Compound 25 Interleukin-2 130 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412395 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412395&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822424 Cc1c(F)cncc1C(=O)Nc1cnc(cn1)-c1cc(ccc1Cl)-c1nnn(C)n1 InChI=1S/C19H14ClFN8O/c1-10-13(6-22-7-15(10)21)19(30)25-17-9-23-16(8-24-17)12-5-11(3-4-14(12)20)18-26-28-29(2)27-18/h3-9H,1-2H3,(H,24,25,30) XHRQWGOTDXSALZ-UHFFFAOYSA-N 412396 N-(5-(2-chloro-5-(2-methyl-2H- tetrazol-5-yl)phenyl)pyrazin-2-yl)-5- fluoro-4-methylnicotinamide::US10399967, Compound 26 Interleukin-2 26.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412396 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412396&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822425 CCc1ccc(cc1-c1cnc(NC(=O)c2cncc(F)c2C)cn1)-c1nnn(C)n1 InChI=1S/C21H19FN8O/c1-4-13-5-6-14(20-27-29-30(3)28-20)7-15(13)18-10-25-19(11-24-18)26-21(31)16-8-23-9-17(22)12(16)2/h5-11H,4H2,1-3H3,(H,25,26,31) IMHIOUOGLKOVTA-UHFFFAOYSA-N 412397 N-(5-(2-ethyl-5-(2-methyl-2H- tetrazol-5-yl)phenyl)pyrazin-2-yl)-5- fluoro-4-methylnicotinamide::US10399967, Compound 27 Interleukin-2 26.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412397 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412397&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822426 Cc1cnc(OC2CC2)cc1-c1ccc(NC(=O)c2cncc(F)c2C)nc1 InChI=1S/C21H19FN4O2/c1-12-8-25-20(28-15-4-5-15)7-16(12)14-3-6-19(24-9-14)26-21(27)17-10-23-11-18(22)13(17)2/h3,6-11,15H,4-5H2,1-2H3,(H,24,26,27) BEDQLVWXFUCSLN-UHFFFAOYSA-N 412398 N-(2'-cyclopropoxy-5'-methyl-[3,4'- bipyridin]-6-yl)-5-fluoro-4- methylnicotinamide::US10399967, Compound 28 Interleukin-2 114 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412398&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822427 CCO\N=C(\c1ccc(OC)cc1)c1ccc(NC(=O)c2cncc(F)c2C)nc1 InChI=1S/C22H21FN4O3/c1-4-30-27-21(15-5-8-17(29-3)9-6-15)16-7-10-20(25-11-16)26-22(28)18-12-24-13-19(23)14(18)2/h5-13H,4H2,1-3H3,(H,25,26,28)/b27-21- FLHIXIGCQSPXEE-MEFGMAGPSA-N 412399 (Z)-N-(5-((ethoxyimino)(4- methoxyphenyl)methyl)pyridin-2- yl)-5-fluoro-4-methylnicotinamide::US10399967, Compound 29 Interleukin-2 210 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412399 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412399&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822428 CO\N=C(/c1ccc(NC(=O)c2cncc(F)c2C)nc1)c1ccc(OC)nc1 InChI=1S/C20H18FN5O3/c1-12-15(10-22-11-16(12)21)20(27)25-17-6-4-13(8-23-17)19(26-29-3)14-5-7-18(28-2)24-9-14/h4-11H,1-3H3,(H,23,25,27)/b26-19+ WOLZTBOXMLUVQB-LGUFXXKBSA-N 412400 (E)-5-fluoro-N-(5-((methoxyimino)(6- methoxypyridin-3- yl)methyl)pyridin-2-yl)-4- methylnicotinamide::US10399967, Compound 30 Interleukin-2 247 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412400 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412400&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822429 COc1ccc(cc1)C1(CC1)c1ccc(NC(=O)c2cncc(F)c2C)cc1 InChI=1S/C23H21FN2O2/c1-15-20(13-25-14-21(15)24)22(27)26-18-7-3-16(4-8-18)23(11-12-23)17-5-9-19(28-2)10-6-17/h3-10,13-14H,11-12H2,1-2H3,(H,26,27) PULXNTOQPGJVSB-UHFFFAOYSA-N 412401 5-fluoro-N-(4-(1-(4- methoxyphenyl)cyclopropyl)phenyl)- 4-methylnicotinamide::US10399967, Compound 31 Interleukin-2 104 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412401 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412401&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822430 Cc1ccncc1C(=O)Nc1ccc(cn1)-c1cc(Oc2ccccn2)ccc1C InChI=1S/C24H20N4O2/c1-16-6-8-19(30-23-5-3-4-11-26-23)13-20(16)18-7-9-22(27-14-18)28-24(29)21-15-25-12-10-17(21)2/h3-15H,1-2H3,(H,27,28,29) NZWMPULZYTZWQM-UHFFFAOYSA-N 412402 4-methyl-N-(5-(2-methyl-5-(pyridin- 2-yloxy)phenyl)pyridin-2- yl)nicotinamide::US10399967, Compound 32 Interleukin-2 91.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412402 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412402&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822431 Cc1ccncc1C(=O)Nc1ccc(cn1)-c1cc(ccc1C)-c1nnn(C)n1 InChI=1S/C21H19N7O/c1-13-4-5-15(20-25-27-28(3)26-20)10-17(13)16-6-7-19(23-11-16)24-21(29)18-12-22-9-8-14(18)2/h4-12H,1-3H3,(H,23,24,29) WZILOPHPPKLXRZ-UHFFFAOYSA-N 412403 4-methyl-N-(5-(2-methyl-5-(2- methyl-2H-tetrazol-5- yl)phenyl)pyridin-2-yl)nicotinamide::US10399967, Compound 33 Interleukin-2 31.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412403 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412403&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822432 Cc1ccncc1C(=O)Nc1cnc(cn1)-c1cc(Oc2cccc(n2)C(F)(F)F)ccc1Cl InChI=1S/C23H15ClF3N5O2/c1-13-7-8-28-10-16(13)22(33)32-20-12-29-18(11-30-20)15-9-14(5-6-17(15)24)34-21-4-2-3-19(31-21)23(25,26)27/h2-12H,1H3,(H,30,32,33) PUUWGIALQPXHGQ-UHFFFAOYSA-N 412404 N-(5-(2-chloro-5-((6- (trifluoromethyl)pyridin-2- yl)oxy)phenyl)pyrazin-2-yl)-4- methylnicotinamide::US10399967, Compound 34 Interleukin-2 26.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412404 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412404&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822433 COc1ccc2n(c(nc2c1)C(F)F)-c1ccc(NC(=O)c2cnccc2C)cc1 InChI=1S/C22H18F2N4O2/c1-13-9-10-25-12-17(13)22(29)26-14-3-5-15(6-4-14)28-19-8-7-16(30-2)11-18(19)27-21(28)20(23)24/h3-12,20H,1-2H3,(H,26,29) LQUFWXZIUFTMTL-UHFFFAOYSA-N 412405 N-(4-(2-(difluoromethyl)-5-methoxy- 1H-benzo[d]imidazol-1-yl)phenyl)-4- methylnicotinamide::US10399967, Compound 35 Interleukin-2 190 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412405 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412405&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822434 Cc1ccncc1C(=O)Nc1cnc(cn1)-c1cc(Oc2ncccc2F)ccc1C InChI=1S/C23H18FN5O2/c1-14-5-6-16(31-23-19(24)4-3-8-26-23)10-17(14)20-12-28-21(13-27-20)29-22(30)18-11-25-9-7-15(18)2/h3-13H,1-2H3,(H,28,29,30) VRJWFWUAZFJYHL-UHFFFAOYSA-N 412406 N-(5-(5-((3-fluoropyridin-2-yl)oxy)-2- methylphenyl)pyrazin-2-yl)-4- methylnicotinamide::US10399967, Compound 36 Interleukin-2 134 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412406 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412406&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822435 Cc1ccncc1C(=O)Nc1ccc(cn1)-c1cc(ccc1Cl)-c1nnn(C)n1 InChI=1S/C20H16ClN7O/c1-12-7-8-22-11-16(12)20(29)24-18-6-4-14(10-23-18)15-9-13(3-5-17(15)21)19-25-27-28(2)26-19/h3-11H,1-2H3,(H,23,24,29) IEXVQFISYQCEBM-UHFFFAOYSA-N 412407 N-(5-(2-chloro-5-(2-methyl-2H- tetrazol-5-yl)phenyl)pyridin-2-yl)-4- methylnicotinamide::US10399967, Compound 37 Interleukin-2 18.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412407 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412407&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822436 Cc1ccncc1C(=O)Nc1cnc(cn1)-c1cc(Oc2ncccc2F)ccc1OC(F)(F)F InChI=1S/C23H15F4N5O3/c1-13-6-8-28-10-16(13)21(33)32-20-12-30-18(11-31-20)15-9-14(4-5-19(15)35-23(25,26)27)34-22-17(24)3-2-7-29-22/h2-12H,1H3,(H,31,32,33) YSXVBGHLHGLISM-UHFFFAOYSA-N 412408 N-(5-(5-((3-fluoropyridin-2-yl)oxy)-2- (trifluoromethoxy)phenyl)pyrazin-2- yl)-4-methylnicotinamide::US10399967, Compound 38 Interleukin-2 79.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412408 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412408&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822437 Cc1ccncc1C(=O)Nc1cnc(cn1)-c1cc(OC2COC2)ccc1C#N InChI=1S/C21H17N5O3/c1-13-4-5-23-8-18(13)21(27)26-20-10-24-19(9-25-20)17-6-15(3-2-14(17)7-22)29-16-11-28-12-16/h2-6,8-10,16H,11-12H2,1H3,(H,25,26,27) MKWZPOYJGXKQCR-UHFFFAOYSA-N 412409 N-(5-(2-cyano-5-(oxetan-3- yloxy)phenyl)pyrazin-2-yl)-4- methylnicotinamide::US10399967, Compound 39 Interleukin-2 1000 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412409 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412409&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822438 COc1ccc2n(c(nc2c1)C(F)(F)F)-c1ccc(NC(=O)c2cnccc2C)cc1 InChI=1S/C22H17F3N4O2/c1-13-9-10-26-12-17(13)20(30)27-14-3-5-15(6-4-14)29-19-8-7-16(31-2)11-18(19)28-21(29)22(23,24)25/h3-12H,1-2H3,(H,27,30) IILURLMOFLTBTD-UHFFFAOYSA-N 412410 N-(4-(5-methoxy-2-(trifluoromethyl)- 1H-benzo[d]imidazol-1-yl)phenyl)-4- methylnicotinamide::US10399967, Compound 40 Interleukin-2 77.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412410 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412410&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822439 Cc1ccncc1C(=O)Nc1ccc(cc1)-c1cccnc1OCc1ccccc1 InChI=1S/C25H21N3O2/c1-18-13-15-26-16-23(18)24(29)28-21-11-9-20(10-12-21)22-8-5-14-27-25(22)30-17-19-6-3-2-4-7-19/h2-16H,17H2,1H3,(H,28,29) HFFBSXYEOBBNRR-UHFFFAOYSA-N 412411 N-(4-(2-(benzyloxy)pyridin-3- yl)phenyl)-4-methylnicotinamide::US10399967, Compound 41 Interleukin-2 1000 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412411 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412411&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822440 COc1nc2cc(OC)ccc2n1-c1ccc(NC(=O)c2cncc(F)c2C)cc1 InChI=1S/C22H19FN4O3/c1-13-17(11-24-12-18(13)23)21(28)25-14-4-6-15(7-5-14)27-20-9-8-16(29-2)10-19(20)26-22(27)30-3/h4-12H,1-3H3,(H,25,28) PNXXZLAFWDEOBC-UHFFFAOYSA-N 412412 N-(4-(2,5-dimethoxy-1H- benzo[d]imidazol-1-yl)phenyl)-5- fluoro-4-methylnicotinamide::US10399967, Compound 42 Interleukin-2 81.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412412 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412412&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822441 COc1nc2cc(OC)ccc2n1-c1ccc(NC(=O)c2cnccc2C)cc1 InChI=1S/C22H20N4O3/c1-14-10-11-23-13-18(14)21(27)24-15-4-6-16(7-5-15)26-20-9-8-17(28-2)12-19(20)25-22(26)29-3/h4-13H,1-3H3,(H,24,27) ZJBOIKJGIQUQIA-UHFFFAOYSA-N 412413 N-(4-(2,5-dimethoxy-1H- benzo[d]imidazol-1-yl)phenyl)-4- methylnicotinamide::US10399967, Compound 43 Interleukin-2 352 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412413 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412413&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822442 Cc1ccncc1C(=O)Nc1cnc(cn1)-c1cc(ccc1C)C#Cc1cccnc1 InChI=1S/C25H19N5O/c1-17-5-6-19(7-8-20-4-3-10-26-13-20)12-21(17)23-15-29-24(16-28-23)30-25(31)22-14-27-11-9-18(22)2/h3-6,9-16H,1-2H3,(H,29,30,31) RXBHKNJYMPEALF-UHFFFAOYSA-N 412414 4-methyl-N-(5-(2-methyl-5-(pyridin- 3-ylethynyl)phenyl)pyrazin-2- yl)nicotinamide::US10399967, Compound 44 Interleukin-2 140 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412414 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412414&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822443 Cc1ccncc1C(=O)Nc1cnc(cn1)-c1cc(ccc1C)-c1nnn(C)n1 InChI=1S/C20H18N8O/c1-12-4-5-14(19-25-27-28(3)26-19)8-15(12)17-10-23-18(11-22-17)24-20(29)16-9-21-7-6-13(16)2/h4-11H,1-3H3,(H,23,24,29) OYNWIVLJAVQIFN-UHFFFAOYSA-N 412415 4-methyl-N-(5-(2-methyl-5-(2- methyl-2H-tetrazol-5- yl)phenyl)pyrazin-2-yl)nicotinamide::US10399967, Compound 45 Interleukin-2 80.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412415&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822444 COc1ccc2n(c(nc2c1)C(F)(F)F)-c1ccc(NC(=O)c2cnccc2C)cn1 InChI=1S/C21H16F3N5O2/c1-12-7-8-25-11-15(12)19(30)27-13-3-6-18(26-10-13)29-17-5-4-14(31-2)9-16(17)28-20(29)21(22,23)24/h3-11H,1-2H3,(H,27,30) CHDJQWZERAWQLN-UHFFFAOYSA-N 412416 N-(6-(5-methoxy-2-(trifluoromethyl)- 1H-benzo[d]imidazol-1-yl)pyridin-3- yl)-4-methylnicotinamide::US10399967, Compound 46 Interleukin-2 156 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412416 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412416&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822445 COc1ccc2n(c(nc2c1)C(F)(F)F)-c1ccc(NC(=O)c2cncc(F)c2C)cn1 InChI=1S/C21H15F4N5O2/c1-11-14(9-26-10-15(11)22)19(31)28-12-3-6-18(27-8-12)30-17-5-4-13(32-2)7-16(17)29-20(30)21(23,24)25/h3-10H,1-2H3,(H,28,31) QHGZSJFWOUQVKV-UHFFFAOYSA-N 412417 5-fluoro-N-(6-(5-methoxy-2- (trifluoromethyl)-1H- benzo[d]imidazol-1-yl)pyridin-3-yl)- 4-methylnicotinamide::US10399967, Compound 47 Interleukin-2 116 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412417 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412417&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822446 CCc1ccc(cc1-c1ccc(NC(=O)c2cnccc2C)nc1)-c1nnn(C)n1 InChI=1S/C22H21N7O/c1-4-15-5-6-16(21-26-28-29(3)27-21)11-18(15)17-7-8-20(24-12-17)25-22(30)19-13-23-10-9-14(19)2/h5-13H,4H2,1-3H3,(H,24,25,30) PXACIEJKKPZBDH-UHFFFAOYSA-N 412418 N-(5-(2-ethyl-5-(2-methyl-2H- tetrazol-5-yl)phenyl)pyridin-2-yl)-4- methylnicotinamide::US10399967, Compound 48 Interleukin-2 22.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412418&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822447 Cc1ccncc1C(=O)Nc1cnc(cn1)-c1cc(Oc2ccccn2)ccc1Cl InChI=1S/C22H16ClN5O2/c1-14-7-9-24-11-17(14)22(29)28-20-13-26-19(12-27-20)16-10-15(5-6-18(16)23)30-21-4-2-3-8-25-21/h2-13H,1H3,(H,27,28,29) WQXPJLXSBWEPJD-UHFFFAOYSA-N 412419 N-(5-(2-chloro-5-(pyridin-2- yloxy)phenyl)pyrazin-2-yl)-4- methylnicotinamide::US10399967, Compound 49 Interleukin-2 45.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412419 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412419&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822448 Cc1ccncc1C(=O)Nc1cnc(cn1)-c1cc2OCOc2cc1C InChI=1S/C19H16N4O3/c1-11-3-4-20-7-14(11)19(24)23-18-9-21-15(8-22-18)13-6-17-16(5-12(13)2)25-10-26-17/h3-9H,10H2,1-2H3,(H,22,23,24) HSSXSAITGGLMQS-UHFFFAOYSA-N 412420 4-methyl-N-(5-(6- methylbenzo[d][1,3]dioxol-5- yl)pyrazin-2-yl)nicotinamide::US10399967, Compound 50 Interleukin-2 205 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412420 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412420&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822449 Cc1cnccc1C(=O)Nc1cnc(cn1)-c1cc(Oc2ccccn2)ccc1OC(F)(F)F InChI=1S/C23H16F3N5O3/c1-14-11-27-9-7-16(14)22(32)31-20-13-29-18(12-30-20)17-10-15(33-21-4-2-3-8-28-21)5-6-19(17)34-23(24,25)26/h2-13H,1H3,(H,30,31,32) PDVFRTORDUOBES-UHFFFAOYSA-N 412421 4-methyl-N-(5-(5-(pyridin-2-yloxy)- 2-(trifluoromethoxy)phenyl)pyrazin- 2-yl)nicotinamide::US10399967, Compound 51 Interleukin-2 50.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412421 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412421&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822450 Cc1ccncc1C(=O)Nc1cnc(cn1)-c1cc(ccc1C)-c1cnn(C)c1 InChI=1S/C22H20N6O/c1-14-4-5-16(17-9-26-28(3)13-17)8-18(14)20-11-25-21(12-24-20)27-22(29)19-10-23-7-6-15(19)2/h4-13H,1-3H3,(H,25,27,29) OQZFKVOZPLQZAT-UHFFFAOYSA-N 412422 4-methyl-N-(5-(2-methyl-5-(1- methyl-1H-pyrazol-4- yl)phenyl)pyrazin-2-yl)nicotinamide::US10399967, Compound 52 Interleukin-2 44.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412422 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412422&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822451 Cc1ccncc1C(=O)Nc1cnc(cn1)-c1cc(ccc1Cl)-c1cnn(C)c1 InChI=1S/C21H17ClN6O/c1-13-5-6-23-9-17(13)21(29)27-20-11-24-19(10-25-20)16-7-14(3-4-18(16)22)15-8-26-28(2)12-15/h3-12H,1-2H3,(H,25,27,29) SRHINFVKXQDHJB-UHFFFAOYSA-N 412423 N-(5-(2-chloro-5-(1-methyl-1H- pyrazol-4-yl)phenyl)pyrazin-2-yl)-4- methylnicotinamide::US10399967, Compound 142::US10399967, Compound 53 Interleukin-2 38.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412423 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412423&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822452 Cc1c(F)cncc1C(=O)Nc1cnc(cn1)-c1cc(Oc2ccccn2)ccc1Cl InChI=1S/C22H15ClFN5O2/c1-13-16(9-25-10-18(13)24)22(30)29-20-12-27-19(11-28-20)15-8-14(5-6-17(15)23)31-21-4-2-3-7-26-21/h2-12H,1H3,(H,28,29,30) XTFDQYOBFJXKHU-UHFFFAOYSA-N 412424 N-(5-(2-chloro-5-(pyridin-2- yloxy)phenyl)pyrazin-2-yl)-5-fluoro- 4-methylnicotinamide::US10399967, Compound 54 Interleukin-2 43.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412424 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412424&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822453 Cc1c(F)cncc1C(=O)Nc1ccc(cc1)C(C)(C)c1ccc(Cl)nc1 InChI=1S/C21H19ClFN3O/c1-13-17(11-24-12-18(13)23)20(27)26-16-7-4-14(5-8-16)21(2,3)15-6-9-19(22)25-10-15/h4-12H,1-3H3,(H,26,27) JTOSMKCADSJEKJ-UHFFFAOYSA-N 412425 N-(4-(2-(6-chloropyridin-3- yl)propan-2-yl)phenyl)-5-fluoro-4- methylnicotinamide::US10399967, Compound 55 Interleukin-2 1000 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412425 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412425&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822454 CCc1ccc(cc1-c1cnc(NC(=O)c2cnccc2C)cn1)-c1nnn(C)n1 InChI=1S/C21H20N8O/c1-4-14-5-6-15(20-26-28-29(3)27-20)9-16(14)18-11-24-19(12-23-18)25-21(30)17-10-22-8-7-13(17)2/h5-12H,4H2,1-3H3,(H,24,25,30) JPBLOHKZJBVVGA-UHFFFAOYSA-N 412426 N-(5-(2-ethyl-5-(2-methyl-2H- tetrazol-5-yl)phenyl)pyrazin-2-yl)-4- methylnicotinamide::US10399967, Compound 56 Interleukin-2 33.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412426 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412426&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822455 Cc1ccncc1C(=O)Nc1cnc(cn1)-c1cc(ccc1Cl)-c1nnn(C)n1 InChI=1S/C19H15ClN8O/c1-11-5-6-21-8-14(11)19(29)24-17-10-22-16(9-23-17)13-7-12(3-4-15(13)20)18-25-27-28(2)26-18/h3-10H,1-2H3,(H,23,24,29) JWIYVNBBFFJHHO-UHFFFAOYSA-N 412427 N-(5-(2-chloro-5-(2-methyl-2H- tetrazol-5-yl)phenyl)pyrazin-2-yl)-4- methylnicotinamide::US10399967, Compound 57 Interleukin-2 28.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412427 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412427&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822456 Cc1c(F)cncc1C(=O)Nc1ccc(cc1)C1(CC1)c1ccc(O)cc1 InChI=1S/C22H19FN2O2/c1-14-19(12-24-13-20(14)23)21(27)25-17-6-2-15(3-7-17)22(10-11-22)16-4-8-18(26)9-5-16/h2-9,12-13,26H,10-11H2,1H3,(H,25,27) ADIFRHJNSNQVKG-UHFFFAOYSA-N 412428 5-fluoro-N-(4-(1-(4- hydroxyphenyl)cyclopropyl)phenyl)- 4-methylnicotinamide::US10399967, Compound 58 Interleukin-2 1000 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412428 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412428&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822457 Cc1ccncc1C(=O)Nc1ccc(cn1)-c1cc(ccc1Cl)-c1cnn(C)c1 InChI=1S/C22H18ClN5O/c1-14-7-8-24-12-19(14)22(29)27-21-6-4-16(10-25-21)18-9-15(3-5-20(18)23)17-11-26-28(2)13-17/h3-13H,1-2H3,(H,25,27,29) BNRLMJXMXMXMBL-UHFFFAOYSA-N 412429 N-(5-(2-chloro-5-(1-methyl-1H- pyrazol-4-yl)phenyl)pyridin-2-yl)-4- methylnicotinamide::US10399967, Compound 59 Interleukin-2 77.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412429 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412429&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822458 Cc1ccncc1C(=O)Nc1ccc(cn1)-c1cc(OC2CC2)ccc1C InChI=1S/C22H21N3O2/c1-14-3-5-18(27-17-6-7-17)11-19(14)16-4-8-21(24-12-16)25-22(26)20-13-23-10-9-15(20)2/h3-5,8-13,17H,6-7H2,1-2H3,(H,24,25,26) DISORLVZTDIFLR-UHFFFAOYSA-N 412430 N-(5-(5-cyclopropoxy-2- methylphenyl)pyridin-2-yl)-4- methylnicotinamide::US10399967, Compound 60 Interleukin-2 132 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412430 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412430&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822459 COc1nc2cc(OC)ccc2n1-c1cnc(NC(=O)c2cnccc2C)cn1 InChI=1S/C20H18N6O3/c1-12-6-7-21-9-14(12)19(27)25-17-10-23-18(11-22-17)26-16-5-4-13(28-2)8-15(16)24-20(26)29-3/h4-11H,1-3H3,(H,22,25,27) NJPMFBKQXMGCGE-UHFFFAOYSA-N 412431 N-(5-(2,5-dimethoxy-1H- benzo[d]imidazol-1-yl)pyrazin-2-yl)- 4-methylnicotinamide::US10399967, Compound 61 Interleukin-2 113 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412431 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412431&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822460 Cc1ccncc1C(=O)Nc1cnc(cn1)-c1cc(OC2CC2)ccc1Cl InChI=1S/C20H17ClN4O2/c1-12-6-7-22-9-16(12)20(26)25-19-11-23-18(10-24-19)15-8-14(4-5-17(15)21)27-13-2-3-13/h4-11,13H,2-3H2,1H3,(H,24,25,26) FAVCYJHGNOQIBK-UHFFFAOYSA-N 412432 N-(5-(2-chloro-5- cyclopropoxyphenyl)pyrazin-2-yl)-4- methylnicotinamide::US10399967, Compound 62::US10399967, Compound 87 Interleukin-2 14.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412432&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822461 COc1ccc(cn1)C(C)(C)c1ccc(NC(=O)c2cncc(F)c2C)cc1 InChI=1S/C22H22FN3O2/c1-14-18(12-24-13-19(14)23)21(27)26-17-8-5-15(6-9-17)22(2,3)16-7-10-20(28-4)25-11-16/h5-13H,1-4H3,(H,26,27) BQIJYOUWKOECPW-UHFFFAOYSA-N 412433 5-fluoro-N-(4-(2-(6-methoxypyridin- 3-yl)propan-2-yl)phenyl)-4- methylnicotinamide::US10399967, Compound 63 Interleukin-2 1000 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412433 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412433&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822462 Cc1c(F)cncc1C(=O)Nc1ccc(cc1)C(C)(C)c1ccc(nc1)N1CCCC1 InChI=1S/C25H27FN4O/c1-17-21(15-27-16-22(17)26)24(31)29-20-9-6-18(7-10-20)25(2,3)19-8-11-23(28-14-19)30-12-4-5-13-30/h6-11,14-16H,4-5,12-13H2,1-3H3,(H,29,31) POSAANQWOVZFAR-UHFFFAOYSA-N 412434 5-fluoro-4-methyl-N-(4-(2-(6- (pyrrolidin-1-yl)pyridin-3-yl)propan- 2-yl)phenyl)nicotinamide::US10399967, Compound 64 Interleukin-2 1000 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412434 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412434&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822463 COc1ccc2n(c(nc2c1)C(F)(F)F)-c1cnc(NC(=O)c2cnccc2C)cn1 InChI=1S/C20H15F3N6O2/c1-11-5-6-24-8-13(11)18(30)28-16-9-26-17(10-25-16)29-15-4-3-12(31-2)7-14(15)27-19(29)20(21,22)23/h3-10H,1-2H3,(H,25,28,30) OEBFJYWANBKWHZ-UHFFFAOYSA-N 412435 N-(5-(5-methoxy-2-(trifluoromethyl)- 1H-benzo[d]imidazol-1-yl)pyrazin-2- yl)-4-methylnicotinamide::US10399967, Compound 65 Interleukin-2 93.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412435 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412435&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822464 Cc1ccncc1C(=O)Nc1cnc(cn1)-c1cc(OC2CC2)ccc1C InChI=1S/C21H20N4O2/c1-13-3-4-16(27-15-5-6-15)9-17(13)19-11-24-20(12-23-19)25-21(26)18-10-22-8-7-14(18)2/h3-4,7-12,15H,5-6H2,1-2H3,(H,24,25,26) KMTSFLAOSDRTFO-UHFFFAOYSA-N 412436 N-(5-(5-cyclopropoxy-2- methylphenyl)pyrazin-2-yl)-4- methylnicotinamide::US10399967, Compound 66 Interleukin-2 91.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412436 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412436&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822465 Cc1ccncc1C(=O)Nc1ccc(cn1)-c1cc(ccc1C)-c1cnn(C)c1 InChI=1S/C23H21N5O/c1-15-4-5-17(19-12-26-28(3)14-19)10-20(15)18-6-7-22(25-11-18)27-23(29)21-13-24-9-8-16(21)2/h4-14H,1-3H3,(H,25,27,29) LDXNJRKBMMEKSI-UHFFFAOYSA-N 412437 4-methyl-N-(5-(2-methyl-5-(1- methyl-1H-pyrazol-4- yl)phenyl)pyridin-2-yl)nicotinamide::US10399967, Compound 67 Interleukin-2 77.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412437 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412437&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822466 CN(C)S(=O)(=O)Oc1ccc(C)c(c1)-c1cnc(NC(=O)c2cnccc2C)cn1 InChI=1S/C20H21N5O4S/c1-13-5-6-15(29-30(27,28)25(3)4)9-16(13)18-11-23-19(12-22-18)24-20(26)17-10-21-8-7-14(17)2/h5-12H,1-4H3,(H,23,24,26) RUKCNHZATBNBQQ-UHFFFAOYSA-N 412438 4-methyl-3-(5-(4- methylnicotinamido)pyrazin-2- yl)phenyl dimethylsulfamate::US10399967, Compound 68 Interleukin-2 84.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412438 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412438&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822467 Cc1ccncc1C(=O)Nc1cnc(cn1)-c1cc(OS(C)(=O)=O)ccc1C InChI=1S/C19H18N4O4S/c1-12-4-5-14(27-28(3,25)26)8-15(12)17-10-22-18(11-21-17)23-19(24)16-9-20-7-6-13(16)2/h4-11H,1-3H3,(H,22,23,24) SGDFAIDYOBCRDU-UHFFFAOYSA-N 412439 4-methyl-3-(5-(4- methylnicotinamido)pyrazin-2- yl)phenyl methanesulfonate::US10399967, Compound 69 Interleukin-2 264 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412439 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412439&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822468 CCc1sc(nc1-c1ccc(NC(=O)c2cncc(F)c2C)nc1)-c1cc(C)on1 InChI=1S/C21H18FN5O2S/c1-4-17-19(26-21(30-17)16-7-11(2)29-27-16)13-5-6-18(24-8-13)25-20(28)14-9-23-10-15(22)12(14)3/h5-10H,4H2,1-3H3,(H,24,25,28) NWRSGVMPOCACIF-UHFFFAOYSA-N 412440 N-(5-(5-ethyl-2-(5-methylisoxazol-3- yl)thiazol-4-yl)pyridin-2-yl)-5-fluoro- 4-methylnicotinamide::US10399967, Compound 70 Interleukin-2 11.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412440 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412440&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822469 Cc1c(F)cncc1C(=O)Nc1ccc(cn1)-c1cc(OC2CC2)ccc1Cl InChI=1S/C21H17ClFN3O2/c1-12-17(10-24-11-19(12)23)21(27)26-20-7-2-13(9-25-20)16-8-15(5-6-18(16)22)28-14-3-4-14/h2,5-11,14H,3-4H2,1H3,(H,25,26,27) ZHGMZQXZAVSBPD-UHFFFAOYSA-N 412441 N-(5-(2-chloro-5- cyclopropoxyphenyl)pyridin-2-yl)-5- fluoro-4-methylnicotinamide::US10399967, Compound 71 Interleukin-2 10.00 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412441&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822470 CCc1sc(nc1-c1ccc(NC(=O)c2cncc(Cl)c2C)nc1)-c1cc(C)on1 InChI=1S/C21H18ClN5O2S/c1-4-17-19(26-21(30-17)16-7-11(2)29-27-16)13-5-6-18(24-8-13)25-20(28)14-9-23-10-15(22)12(14)3/h5-10H,4H2,1-3H3,(H,24,25,28) ZFKBBEMKCLPVBE-UHFFFAOYSA-N 412442 5-chloro-N-(5-(5-ethyl-2-(5- methylisoxazol-3-yl)thiazol-4- yl)pyridin-2-yl)-4- methylnicotinamide::US10399967, Compound 72 Interleukin-2 10.00 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412442 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412442&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822471 CCc1sc(nc1-c1ccc(NC(=O)c2cncc(Br)c2C)nc1)-c1cc(C)on1 InChI=1S/C21H18BrN5O2S/c1-4-17-19(26-21(30-17)16-7-11(2)29-27-16)13-5-6-18(24-8-13)25-20(28)14-9-23-10-15(22)12(14)3/h5-10H,4H2,1-3H3,(H,24,25,28) PECZEWOOUGCRAN-UHFFFAOYSA-N 412443 5-bromo-N-(5-(5-ethyl-2-(5- methylisoxazol-3-yl)thiazol-4- yl)pyridin-2-yl)-4- methylnicotinamide::US10399967, Compound 73 Interleukin-2 9.00 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412443&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822472 Cc1c(F)cncc1C(=O)Nc1cnc(cn1)C1(CC1)c1ccccc1 InChI=1S/C20H17FN4O/c1-13-15(9-22-10-16(13)21)19(26)25-18-12-23-17(11-24-18)20(7-8-20)14-5-3-2-4-6-14/h2-6,9-12H,7-8H2,1H3,(H,24,25,26) OLHQHBHMZHZWDB-UHFFFAOYSA-N 412444 5-fluoro-4-methyl-N-(5-(1- phenylcyclopropyl)pyrazin-2- yl)nicotinamide::US10399967, Compound 74 Interleukin-2 1000 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412444 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412444&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822473 Cc1ccncc1C(=O)Nc1ccc(cn1)-c1cc(OC2CC2)ccc1Cl InChI=1S/C21H18ClN3O2/c1-13-8-9-23-12-18(13)21(26)25-20-7-2-14(11-24-20)17-10-16(5-6-19(17)22)27-15-3-4-15/h2,5-12,15H,3-4H2,1H3,(H,24,25,26) DFYYEVZBHMBIMH-UHFFFAOYSA-N 412445 N-(5-(2-chloro-5- cyclopropoxyphenyl)pyridin-2-yl)-4- methylnicotinamide::US10399967, Compound 75 Interleukin-2 9.00 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412445&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822474 CCc1sc(nc1-c1ccc(NC(=O)c2cncc(C#N)c2C)nc1)-c1cc(C)on1 InChI=1S/C22H18N6O2S/c1-4-18-20(27-22(31-18)17-7-12(2)30-28-17)14-5-6-19(25-10-14)26-21(29)16-11-24-9-15(8-23)13(16)3/h5-7,9-11H,4H2,1-3H3,(H,25,26,29) WNSLOPPIXVIMJA-UHFFFAOYSA-N 412446 5-cyano-N-(5-(5-ethyl-2-(5- methylisoxazol-3-yl)thiazol-4- yl)pyridin-2-yl)-4- methylnicotinamide::US10399967, Compound 76 Interleukin-2 13.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412446&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822475 CCc1sc(nc1-c1ccc(NC(=O)c2cnccc2C)nc1)-c1cc(C)on1 InChI=1S/C21H19N5O2S/c1-4-17-19(25-21(29-17)16-9-13(3)28-26-16)14-5-6-18(23-10-14)24-20(27)15-11-22-8-7-12(15)2/h5-11H,4H2,1-3H3,(H,23,24,27) OVVPWMGHORFVRX-UHFFFAOYSA-N 412447 N-(5-(5-ethyl-2-(5-methylisoxazol-3- yl)thiazol-4-yl)pyridin-2-yl)-4- methylnicotinamide::US10399967, Compound 77 Interleukin-2 11.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412447&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822476 COC(=O)c1ccc(cc1)C1(CC1)c1cnc(NC(=O)c2cncc(F)c2C)cn1 InChI=1S/C22H19FN4O3/c1-13-16(9-24-10-17(13)23)20(28)27-19-12-25-18(11-26-19)22(7-8-22)15-5-3-14(4-6-15)21(29)30-2/h3-6,9-12H,7-8H2,1-2H3,(H,26,27,28) CYZFPILUAULZLO-UHFFFAOYSA-N 412448 US10399967, Compound 78::methyl 4-(1-(5-(5-fluoro-4- methylnicotinamido)pyrazin-2- yl)cyclopropyl)benzoate Interleukin-2 78.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412448&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822477 Cc1ccc(OC2CC2)cc1-c1cnc(NC(=O)c2cncc(F)c2C)cn1 InChI=1S/C21H19FN4O2/c1-12-3-4-15(28-14-5-6-14)7-16(12)19-10-25-20(11-24-19)26-21(27)17-8-23-9-18(22)13(17)2/h3-4,7-11,14H,5-6H2,1-2H3,(H,25,26,27) OEDBGJMOXQAAGU-UHFFFAOYSA-N 412449 N-(5-(5-cyclopropoxy-2- methylphenyl)pyrazin-2-yl)-5-fluoro- 4-methylnicotinamide::US10399967, Compound 79 Interleukin-2 48.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412449 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412449&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822478 Cc1c(cnn1C)-c1ccc(Cl)c(c1)-c1cnc(NC(=O)c2cnccc2C)cn1 InChI=1S/C22H19ClN6O/c1-13-6-7-24-9-17(13)22(30)28-21-12-25-20(11-26-21)16-8-15(4-5-19(16)23)18-10-27-29(3)14(18)2/h4-12H,1-3H3,(H,26,28,30) PCXYUPSGVYKBSA-UHFFFAOYSA-N 412450 N-(5-(2-chloro-5-(1,5-dimethyl-1H- pyrazol-4-yl)phenyl)pyrazin-2-yl)-4- methylnicotinamide::US10399967, Compound 80 Interleukin-2 26.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412450 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412450&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822479 Cc1c(Br)cncc1C(=O)Nc1cnc(cn1)-c1cc(OC2CC2)ccc1Cl InChI=1S/C20H16BrClN4O2/c1-11-15(7-23-8-16(11)21)20(27)26-19-10-24-18(9-25-19)14-6-13(4-5-17(14)22)28-12-2-3-12/h4-10,12H,2-3H2,1H3,(H,25,26,27) PRNVRFDVJHPQFQ-UHFFFAOYSA-N 412451 5-bromo-N-(5-(2-chloro-5- cyclopropoxyphenyl)pyrazin-2-yl)-4- methylnicotinamide::US10399967, Compound 81 Interleukin-2 11.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412451 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412451&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822480 C\C=C(\c1ccc(F)nc1)c1ccc(NC(=O)c2cncc(F)c2C)nc1 InChI=1S/C20H16F2N4O/c1-3-15(13-4-6-18(22)24-8-13)14-5-7-19(25-9-14)26-20(27)16-10-23-11-17(21)12(16)2/h3-11H,1-2H3,(H,25,26,27)/b15-3- OULVYHJQMQEGLD-CQPUUCJISA-N 412452 (E)-5-fluoro-N-(5-(1-(6-fluoropyridin- 3-yl)prop-1-en-1-yl)pyridin-2-yl)-4- methylnicotinamide::US10399967, Compound 82 Interleukin-2 277 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412452 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412452&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822481 C\C=C(\c1ccc(Br)cc1)c1cnc(NC(=O)c2cnccc2C)cn1 InChI=1S/C20H17BrN4O/c1-3-16(14-4-6-15(21)7-5-14)18-11-24-19(12-23-18)25-20(26)17-10-22-9-8-13(17)2/h3-12H,1-2H3,(H,24,25,26)/b16-3- OIYLKHVVJNXFTG-XFQLMFQHSA-N 412453 (Z)-N-(5-(1-(4-bromophenyl)prop-1- en-1-yl)pyrazin-2-yl)-4- methylnicotinamide::US10399967, Compound 83 Interleukin-2 20.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412453 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412453&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822482 C\C=C(\c1ccc(O)cc1)c1ccc(NC(=O)c2cncc(F)c2C)nc1 InChI=1S/C21H18FN3O2/c1-3-17(14-4-7-16(26)8-5-14)15-6-9-20(24-10-15)25-21(27)18-11-23-12-19(22)13(18)2/h3-12,26H,1-2H3,(H,24,25,27)/b17-3- YQWPEMWGUXCJLQ-YPEHOIGNSA-N 412454 (Z)-5-fluoro-N-(5-(1-(4- hydroxyphenyl)prop-1-en-1- yl)pyridin-2-yl)-4- methylnicotinamide::US10399967, Compound 84 Interleukin-2 173 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412454 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412454&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822483 Cc1ccncc1C(=O)Nc1cnc(cn1)-c1cc(ccc1OC1CC1)-c1cnn(C)c1 InChI=1S/C24H22N6O2/c1-15-7-8-25-11-20(15)24(31)29-23-13-26-21(12-27-23)19-9-16(17-10-28-30(2)14-17)3-6-22(19)32-18-4-5-18/h3,6-14,18H,4-5H2,1-2H3,(H,27,29,31) QWVKAZFNEIYDFE-UHFFFAOYSA-N 412455 N-(5-(2-cyclopropoxy-5-(1-methyl- 1H-pyrazol-4-yl)phenyl)pyrazin-2- yl)-4-methylnicotinamide::US10399967, Compound 86 Interleukin-2 61.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412455 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412455&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822484 Cc1ccncc1C(=O)Nc1cnc(cn1)-c1cc(OC2CC2)ccc1Cl InChI=1S/C20H17ClN4O2/c1-12-6-7-22-9-16(12)20(26)25-19-11-23-18(10-24-19)15-8-14(4-5-17(15)21)27-13-2-3-13/h4-11,13H,2-3H2,1H3,(H,24,25,26) FAVCYJHGNOQIBK-UHFFFAOYSA-N 412432 N-(5-(2-chloro-5- cyclopropoxyphenyl)pyrazin-2-yl)-4- methylnicotinamide::US10399967, Compound 62::US10399967, Compound 87 Interleukin-2 12.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412432&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822485 C\C=C(\c1ccc(cc1)-c1ccccn1)c1ccc(NC(=O)c2cncc(F)c2C)nc1 InChI=1S/C26H21FN4O/c1-3-21(18-7-9-19(10-8-18)24-6-4-5-13-29-24)20-11-12-25(30-14-20)31-26(32)22-15-28-16-23(27)17(22)2/h3-16H,1-2H3,(H,30,31,32)/b21-3- AQRKWAXHZQQPDW-OSSHXBFKSA-N 412457 (Z)-5-fluoro-4-methyl-N-(5-(1-(4- (pyridin-2-yl)phenyl)prop-1-en-1- yl)pyridin-2-yl)nicotinamide::US10399967, Compound 88 Interleukin-2 65.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412457 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412457&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822486 C\C=C(\c1ccc(cc1)C#N)c1ccc(NC(=O)c2cncc(F)c2C)nc1 InChI=1S/C22H17FN4O/c1-3-18(16-6-4-15(10-24)5-7-16)17-8-9-21(26-11-17)27-22(28)19-12-25-13-20(23)14(19)2/h3-9,11-13H,1-2H3,(H,26,27,28)/b18-3- ZYYAMXQVWUDNPM-ZUWFHJRGSA-N 412458 (Z)-N-(5-(1-(4-cyanophenyl)prop-1- en-1-yl)pyridin-2-yl)-5-fluoro-4- methylnicotinamide::US10399967, Compound 89 Interleukin-2 113 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412458&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822487 CC(C)Oc1ccc(Cl)c(c1)-c1ccc(NC(=O)c2cnccc2C)nc1 InChI=1S/C21H20ClN3O2/c1-13(2)27-16-5-6-19(22)17(10-16)15-4-7-20(24-11-15)25-21(26)18-12-23-9-8-14(18)3/h4-13H,1-3H3,(H,24,25,26) SYPRQGATPFXFLK-UHFFFAOYSA-N 412459 N-(5-(2-chloro-5- isopropoxyphenyl)pyridin-2-yl)-4- methylnicotinamide::US10399967, Compound 90 Interleukin-2 13.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412459&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822488 CN(C)c1ccc(C)c(c1)-c1ccc(NC(=O)c2cnccc2C)nc1 InChI=1S/C21H22N4O/c1-14-5-7-17(25(3)4)11-18(14)16-6-8-20(23-12-16)24-21(26)19-13-22-10-9-15(19)2/h5-13H,1-4H3,(H,23,24,26) YZGCLBKBFRYUOY-UHFFFAOYSA-N 412460 N-(5-(5-(dimethylamino)-2- methylphenyl)pyridin-2-yl)-4- methylnicotinamide::US10399967, Compound 91 Interleukin-2 91.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412460 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412460&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822489 Cc1ccncc1C(=O)Nc1ccc(cn1)-c1cc(ccc1C(F)(F)F)-c1nnn(C)n1 InChI=1S/C21H16F3N7O/c1-12-7-8-25-11-16(12)20(32)27-18-6-4-14(10-26-18)15-9-13(19-28-30-31(2)29-19)3-5-17(15)21(22,23)24/h3-11H,1-2H3,(H,26,27,32) BTNCEIJPVCQTMB-UHFFFAOYSA-N 412461 4-methyl-N-(5-(5-(2-methyl-2H- tetrazol-5-yl)-2- (trifluoromethyl)phenyl)pyridin-2- yl)nicotinamide::US10399967, Compound 92 Interleukin-2 40.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412461 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412461&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822490 Cc1ccncc1C(=O)Nc1cnc(cn1)-c1cc(OS(C)(=O)=O)ccc1Cl InChI=1S/C18H15ClN4O4S/c1-11-5-6-20-8-14(11)18(24)23-17-10-21-16(9-22-17)13-7-12(3-4-15(13)19)27-28(2,25)26/h3-10H,1-2H3,(H,22,23,24) XPAKKKFONPDJIX-UHFFFAOYSA-N 412462 4-chloro-3-(5-(4- methylnicotinamido)pyrazin-2- yl)phenyl methanesulfonate::US10399967, Compound 93 Interleukin-2 57.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412462 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412462&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822491 CCc1sc(nc1-c1ccc(NC(=O)c2cncc(c2C)[N+]([O-])=O)nc1)-c1cc(C)on1 InChI=1S/C21H18N6O4S/c1-4-17-19(25-21(32-17)15-7-11(2)31-26-15)13-5-6-18(23-8-13)24-20(28)14-9-22-10-16(12(14)3)27(29)30/h5-10H,4H2,1-3H3,(H,23,24,28) QNIVAFLUOVDHNM-UHFFFAOYSA-N 412463 N-(5-(5-ethyl-2-(5-methylisoxazol-3- yl)thiazol-4-yl)pyridin-2-yl)-4- methyl-5-nitronicotinamide::US10399967, Compound 94 Interleukin-2 18.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412463 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412463&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822492 COc1ccc(cc1)C1(CC1)c1cnc(NC(=O)c2cncc(F)c2C)cn1 InChI=1S/C21H19FN4O2/c1-13-16(9-23-10-17(13)22)20(27)26-19-12-24-18(11-25-19)21(7-8-21)14-3-5-15(28-2)6-4-14/h3-6,9-12H,7-8H2,1-2H3,(H,25,26,27) FALSUNJGFBHOAK-UHFFFAOYSA-N 412464 5-fluoro-N-(5-(1-(4- methoxyphenyl)cyclopropyl)pyrazin- 2-yl)-4-methylnicotinamide::US10399967, Compound 95 Interleukin-2 274 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412464 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412464&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822493 C\C=C(\c1ccc(Br)cc1)c1ccc(NC(=O)c2cncc(F)c2C)nc1 InChI=1S/C21H17BrFN3O/c1-3-17(14-4-7-16(22)8-5-14)15-6-9-20(25-10-15)26-21(27)18-11-24-12-19(23)13(18)2/h3-12H,1-2H3,(H,25,26,27)/b17-3- ADJZVZYXLRGJER-YPEHOIGNSA-N 412465 (Z)-N-(5-(1-(4-bromophenyl)prop-1- en-1-yl)pyridin-2-yl)-5-fluoro-4- methylnicotinamide hydrochloride::US10399967, Compound 136::US10399967, Compound 96 Interleukin-2 105 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412465 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412465&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822494 COc1ccc(cc1)C(=C(C)C)c1ccc(NC(=O)c2cncc(F)c2C)nc1 InChI=1S/C23H22FN3O2/c1-14(2)22(16-5-8-18(29-4)9-6-16)17-7-10-21(26-11-17)27-23(28)19-12-25-13-20(24)15(19)3/h5-13H,1-4H3,(H,26,27,28) KAGKHNUVGIAPJD-UHFFFAOYSA-N 412466 5-fluoro-N-(5-(1-(4-methoxyphenyl)- 2-methylprop-1-en-1-yl)pyridin-2- yl)-4-methylnicotinamide::US10399967, Compound 97 Interleukin-2 51.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412466 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412466&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822495 CCc1sc(nc1-c1ccc(NC(=O)c2cncc(C)c2C)nc1)-c1cc(C)on1 InChI=1S/C22H21N5O2S/c1-5-18-20(26-22(30-18)17-8-13(3)29-27-17)15-6-7-19(24-10-15)25-21(28)16-11-23-9-12(2)14(16)4/h6-11H,5H2,1-4H3,(H,24,25,28) UAUJZSNVAMWPTD-UHFFFAOYSA-N 412467 N-(5-(5-ethyl-2-(5-methylisoxazol-3- yl)thiazol-4-yl)pyridin-2-yl)-4,5- dimethylnicotinamide::US10399967, Compound 98 Interleukin-2 8.00 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412467 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412467&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822496 Cc1cc(no1)-c1nc(c(C)s1)-c1ccc(NC(=O)c2cncc(F)c2C)nc1 InChI=1S/C20H16FN5O2S/c1-10-6-16(26-28-10)20-25-18(12(3)29-20)13-4-5-17(23-7-13)24-19(27)14-8-22-9-15(21)11(14)2/h4-9H,1-3H3,(H,23,24,27) NPKPPHKBRDILHQ-UHFFFAOYSA-N 412468 5-fluoro-4-methyl-N-(5-(5-methyl-2- (5-methylisoxazol-3-yl)thiazol-4- yl)pyridin-2-yl)nicotinamide::US10399967, Compound 99 Interleukin-2 11.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412468 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412468&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822497 COc1ccc(cc1)C(=C(C)C)c1ccc(NC(=O)c2cncc(F)c2C)cn1 InChI=1S/C23H22FN3O2/c1-14(2)22(16-5-8-18(29-4)9-6-16)21-10-7-17(11-26-21)27-23(28)19-12-25-13-20(24)15(19)3/h5-13H,1-4H3,(H,27,28) UAEIAOBKMXBDDE-UHFFFAOYSA-N 412469 5-fluoro-N-(6-(1-(4-methoxyphenyl)- 2-methylprop-1-en-1-yl)pyridin-3- yl)-4-methylnicotinamide::US10399967, Compound 100 Interleukin-2 1000 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412469 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412469&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822498 Cc1ccncc1C(=O)Nc1cnc(cn1)-c1cc(ccc1C)-c1ccn(C)n1 InChI=1S/C22H20N6O/c1-14-4-5-16(19-7-9-28(3)27-19)10-17(14)20-12-25-21(13-24-20)26-22(29)18-11-23-8-6-15(18)2/h4-13H,1-3H3,(H,25,26,29) MPWAABMGEIVHFZ-UHFFFAOYSA-N 412470 4-methyl-N-(5-(2-methyl-5-(1- methyl-1H-pyrazol-3- yl)phenyl)pyrazin-2-yl)nicotinamide::US10399967, Compound 101 Interleukin-2 127 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412470 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412470&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822499 COc1ccc(cc1)C(=C(C)C)c1ccc(NC(=O)c2cnccc2C)nc1 InChI=1S/C23H23N3O2/c1-15(2)22(17-5-8-19(28-4)9-6-17)18-7-10-21(25-13-18)26-23(27)20-14-24-12-11-16(20)3/h5-14H,1-4H3,(H,25,26,27) STFMBYHFXSYFGK-UHFFFAOYSA-N 412471 N-(5-(1-(4-methoxyphenyl)-2- methylprop-1-en-1-yl)pyridin-2-yl)- 4-methylnicotinamide::US10399967, Compound 102 Interleukin-2 116 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412471 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412471&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822500 COc1ccc(cc1)C(=C\C)\c1ccc(NC(=O)c2cncc(F)c2C)nc1 InChI=1S/C22H20FN3O2/c1-4-18(15-5-8-17(28-3)9-6-15)16-7-10-21(25-11-16)26-22(27)19-12-24-13-20(23)14(19)2/h4-13H,1-3H3,(H,25,26,27)/b18-4- QFFNNASXVINRJC-LMXLVEHLSA-N 412472 (Z)-5-fluoro-N-(5-(1-(4- methoxyphenyl)prop-1-en-1- yl)pyridin-2-yl)-4- methylnicotinamide::US10399967, Compound 103 Interleukin-2 16.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412472 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412472&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822501 COC(=O)c1ccc(cc1)C(=C\C)\c1ccc(NC(=O)c2cncc(F)c2C)nc1 InChI=1S/C23H20FN3O3/c1-4-18(15-5-7-16(8-6-15)23(29)30-3)17-9-10-21(26-11-17)27-22(28)19-12-25-13-20(24)14(19)2/h4-13H,1-3H3,(H,26,27,28)/b18-4- YASSXIMUCLLCDR-LMXLVEHLSA-N 412473 (Z)-methyl 4-(1-(6-(5-fluoro-4- methylnicotinamido)pyridin-3- yl)prop-1-en-1-yl)benzoate::US10399967, Compound 104 Interleukin-2 18.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412473 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412473&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822502 CCC(c1ccc(OC)cc1)c1ccc(NC(=O)c2cncc(F)c2C)nc1 InChI=1S/C22H22FN3O2/c1-4-18(15-5-8-17(28-3)9-6-15)16-7-10-21(25-11-16)26-22(27)19-12-24-13-20(23)14(19)2/h5-13,18H,4H2,1-3H3,(H,25,26,27) PCYRPXBFMJOSLR-UHFFFAOYSA-N 412474 5-fluoro-N-(5-(1-(4- methoxyphenyl)propyl)pyridin-2- yl)-4-methylnicotinamide::US10399967, Compound 105 Interleukin-2 1000 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412474&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822503 CCc1sc(nc1-c1ccc(NC(=O)c2cncc(CC)c2C)nc1)-c1cc(C)on1 InChI=1S/C23H23N5O2S/c1-5-15-10-24-12-17(14(15)4)22(29)26-20-8-7-16(11-25-20)21-19(6-2)31-23(27-21)18-9-13(3)30-28-18/h7-12H,5-6H2,1-4H3,(H,25,26,29) SAZOOACEHSAKGV-UHFFFAOYSA-N 412475 5-ethyl-N-(5-(5-ethyl-2-(5- methylisoxazol-3-yl)thiazol-4- yl)pyridin-2-yl)-4- methylnicotinamide::US10399967, Compound 108 Interleukin-2 8.00 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412475 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412475&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822504 CCc1sc(nc1-c1ccc(NC(=O)c2cncc(F)c2C)nc1)-c1cc(C)no1 InChI=1S/C21H18FN5O2S/c1-4-17-19(26-21(30-17)16-7-11(2)27-29-16)13-5-6-18(24-8-13)25-20(28)14-9-23-10-15(22)12(14)3/h5-10H,4H2,1-3H3,(H,24,25,28) NUMCRTRVMBIALI-UHFFFAOYSA-N 412476 N-(5-(5-ethyl-2-(3-methylisoxazol-5- yl)thiazol-4-yl)pyridin-2-yl)-5-fluoro- 4-methylnicotinamide::US10399967, Compound 109 Interleukin-2 10.00 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412476 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412476&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822505 COc1ccc(cc1-c1cnc(NC(=O)c2cnccc2C)cn1)-c1cnn(C)c1 InChI=1S/C22H20N6O2/c1-14-6-7-23-10-18(14)22(29)27-21-12-24-19(11-25-21)17-8-15(4-5-20(17)30-3)16-9-26-28(2)13-16/h4-13H,1-3H3,(H,25,27,29) VUJNQEJOPMEUMT-UHFFFAOYSA-N 412477 N-(5-(2-methoxy-5-(1-methyl-1H- pyrazol-4-yl)phenyl)pyrazin-2-yl)-4- methylnicotinamide::US10399967, Compound 110 Interleukin-2 116 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412477&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822506 C\C=C(\c1ccc(cc1)-c1cnn(C)c1)c1ccc(NC(=O)c2cncc(F)c2C)nc1 InChI=1S/C25H22FN5O/c1-4-21(18-7-5-17(6-8-18)20-12-29-31(3)15-20)19-9-10-24(28-11-19)30-25(32)22-13-27-14-23(26)16(22)2/h4-15H,1-3H3,(H,28,30,32)/b21-4- KPAILJMSVFUPDF-IGLQUIOVSA-N 412478 (Z)-5-fluoro-4-methyl-N-(5-(1-(4-(1- methyl-1H-pyrazol-4- yl)phenyl)prop-1-en-1-yl)pyridin-2- yl)nicotinamide::US10399967, Compound 111::US10399967, Compound 145 Interleukin-2 876 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412478 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412478&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822507 CCc1sc(nc1-c1ccc(NC(=O)c2cncc(F)c2C)nc1)-c1ccon1 InChI=1S/C20H16FN5O2S/c1-3-16-18(25-20(29-16)15-6-7-28-26-15)12-4-5-17(23-8-12)24-19(27)13-9-22-10-14(21)11(13)2/h4-10H,3H2,1-2H3,(H,23,24,27) PRFOJIMWSJYGKM-UHFFFAOYSA-N 412479 N-(5-(5-ethyl-2-(isoxazol-3- yl)thiazol-4-yl)pyridin-2-yl)-5-fluoro- 4-methylnicotinamide::US10399967, Compound 112 Interleukin-2 10.00 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412479&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822508 Cc1nc(co1)-c1ccc(C)c(c1)-c1ccc(NC(=O)c2cnccc2C)nc1 InChI=1S/C23H20N4O2/c1-14-4-5-17(21-13-29-16(3)26-21)10-19(14)18-6-7-22(25-11-18)27-23(28)20-12-24-9-8-15(20)2/h4-13H,1-3H3,(H,25,27,28) CEINHZFJTKWFFI-UHFFFAOYSA-N 412480 4-methyl-N-(5-(2-methyl-5-(2- methyloxazol-4-yl)phenyl)pyridin-2- yl)nicotinamide::US10399967, Compound 113 Interleukin-2 45.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412480 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412480&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822509 Cc1c(Cl)cncc1C(=O)Nc1cnc(cn1)-c1cc(ccc1Cl)-c1cnn(C)c1 InChI=1S/C21H16Cl2N6O/c1-12-16(7-24-8-18(12)23)21(30)28-20-10-25-19(9-26-20)15-5-13(3-4-17(15)22)14-6-27-29(2)11-14/h3-11H,1-2H3,(H,26,28,30) MQQFEUGXIFNMMZ-UHFFFAOYSA-N 412481 5-chloro-N-(5-(2-chloro-5-(1-methyl- 1H-pyrazol-4-yl)phenyl)pyrazin-2- yl)-4-methylnicotinamide::US10399967, Compound 114 Interleukin-2 11.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412481 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412481&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822510 Cc1c(F)cncc1C(=O)Nc1ccc(cn1)-c1cc(ccc1Cl)-c1cnn(C)c1 InChI=1S/C22H17ClFN5O/c1-13-18(10-25-11-20(13)24)22(30)28-21-6-4-15(8-26-21)17-7-14(3-5-19(17)23)16-9-27-29(2)12-16/h3-12H,1-2H3,(H,26,28,30) ZHPKIPDWBIKVIJ-UHFFFAOYSA-N 412482 N-(5-(2-chloro-5-(1-methyl-1H- pyrazol-4-yl)phenyl)pyridin-2-yl)-5- fluoro-4-methylnicotinamide::US10399967, Compound 115 Interleukin-2 14.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412482 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412482&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822511 Cc1c(Br)cncc1C(=O)Nc1ccc(cn1)-c1cc(ccc1Cl)-c1cnn(C)c1 InChI=1S/C22H17BrClN5O/c1-13-18(10-25-11-19(13)23)22(30)28-21-6-4-15(8-26-21)17-7-14(3-5-20(17)24)16-9-27-29(2)12-16/h3-12H,1-2H3,(H,26,28,30) BJJDUFUZAMMZNZ-UHFFFAOYSA-N 412483 5-bromo-N-(5-(2-chloro-5-(1-methyl- 1H-pyrazol-4-yl)phenyl)pyridin-2- yl)-4-methylnicotinamide::US10399967, Compound 116 Interleukin-2 14.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412483&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822512 Cc1cncc(C(=O)Nc2ccc(cn2)-c2cc(ccc2Cl)-c2cnn(C)c2)c1C InChI=1S/C23H20ClN5O/c1-14-9-25-12-20(15(14)2)23(30)28-22-7-5-17(10-26-22)19-8-16(4-6-21(19)24)18-11-27-29(3)13-18/h4-13H,1-3H3,(H,26,28,30) HMDNHHIAXCHPPZ-UHFFFAOYSA-N 412484 N-(5-(2-chloro-5-(1-methyl-1H- pyrazol-4-yl)phenyl)pyridin-2-yl)- 4,5-dimethylnicotinamide::US10399967, Compound 117 Interleukin-2 72.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412484&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822513 COc1ccc(cn1)C(=C\C)\c1ccc(NC(=O)c2cncc(F)c2C)nc1 InChI=1S/C21H19FN4O2/c1-4-16(15-6-8-20(28-3)25-10-15)14-5-7-19(24-9-14)26-21(27)17-11-23-12-18(22)13(17)2/h4-12H,1-3H3,(H,24,26,27)/b16-4+ WEHAJZIBFCCJMI-AYSLTRBKSA-N 412485 (E)-5-fluoro-N-(5-(1-(6- methoxypyridin-3-yl)prop-1-en-1- yl)pyridin-2-yl)-4- methylnicotinamide::US10399967, Compound 118 Interleukin-2 43.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412485 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412485&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822514 CCC(c1ccc(NC(=O)c2cncc(F)c2C)nc1)c1ccc(OC)nc1 InChI=1S/C21H21FN4O2/c1-4-16(15-6-8-20(28-3)25-10-15)14-5-7-19(24-9-14)26-21(27)17-11-23-12-18(22)13(17)2/h5-12,16H,4H2,1-3H3,(H,24,26,27) KZYJXAZCBONCCW-UHFFFAOYSA-N 412486 5-fluoro-N-(5-(1-(6-methoxypyridin- 3-yl)propyl)pyridin-2-yl)-4- methylnicotinamide::US10399967, Compound 119 Interleukin-2 140 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412486 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412486&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822515 C\C=C(\c1ccc(cc1)-c1nccs1)c1ccc(NC(=O)c2cncc(F)c2C)nc1 InChI=1S/C24H19FN4OS/c1-3-19(16-4-6-17(7-5-16)24-27-10-11-31-24)18-8-9-22(28-12-18)29-23(30)20-13-26-14-21(25)15(20)2/h3-14H,1-2H3,(H,28,29,30)/b19-3- ZVSSQYNGHYURNS-OQOIWIOPSA-N 412487 (Z)-5-fluoro-4-methyl-N-(5-(1-(4- (thiazol-2-yl)phenyl)prop-1-en-1- yl)pyridin-2-yl)nicotinamide::US10399967, Compound 120 Interleukin-2 31.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412487 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412487&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822516 Cc1c(Br)cncc1C(=O)Nc1cnc(cn1)-c1cc(ccc1Cl)-c1cnn(C)c1 InChI=1S/C21H16BrClN6O/c1-12-16(7-24-8-17(12)22)21(30)28-20-10-25-19(9-26-20)15-5-13(3-4-18(15)23)14-6-27-29(2)11-14/h3-11H,1-2H3,(H,26,28,30) VWRARRSYAPYIAC-UHFFFAOYSA-N 412488 5-bromo-N-(5-(2-chloro-5-(1-methyl- 1H-pyrazol-4-yl)phenyl)pyrazin-2- yl)-4-methylnicotinamide::US10399967, Compound 121 Interleukin-2 11.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412488 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412488&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822517 Cc1c(cncc1C(=O)Nc1ccc(cn1)-c1cc(ccc1Cl)-c1cnn(C)c1)C#N InChI=1S/C23H17ClN6O/c1-14-17(8-25)9-26-12-20(14)23(31)29-22-6-4-16(10-27-22)19-7-15(3-5-21(19)24)18-11-28-30(2)13-18/h3-7,9-13H,1-2H3,(H,27,29,31) JPQXSDAGNKBZJH-UHFFFAOYSA-N 412489 N-(5-(2-chloro-5-(1-methyl-1H- pyrazol-4-yl)phenyl)pyridin-2-yl)-5- cyano-4-methylnicotinamide::US10399967, Compound 122 Interleukin-2 10.00 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412489 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412489&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822518 Cc1c(F)cncc1C(=O)Nc1cnc(cn1)-c1cc(ccc1Cl)-c1cnn(C)c1 InChI=1S/C21H16ClFN6O/c1-12-16(7-24-8-18(12)23)21(30)28-20-10-25-19(9-26-20)15-5-13(3-4-17(15)22)14-6-27-29(2)11-14/h3-11H,1-2H3,(H,26,28,30) OCUBPPZNFSDYML-UHFFFAOYSA-N 412490 N-(5-(2-chloro-5-(1-methyl-1H- pyrazol-4-yl)phenyl)pyrazin-2-yl)-5- fluoro-4-methylnicotinamide::US10399967, Compound 123 Interleukin-2 18.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412490 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412490&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822519 Cc1nc(cs1)-c1ccc(C)c(c1)-c1cnc(NC(=O)c2cnccc2C)cn1 InChI=1S/C22H19N5OS/c1-13-4-5-16(20-12-29-15(3)26-20)8-17(13)19-10-25-21(11-24-19)27-22(28)18-9-23-7-6-14(18)2/h4-12H,1-3H3,(H,25,27,28) ZTLUQAOTEKRUMU-UHFFFAOYSA-N 412491 4-methyl-N-(5-(2-methyl-5-(2- methylthiazol-4-yl)phenyl)pyrazin-2- yl)nicotinamide::US10399967, Compound 124 Interleukin-2 477 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412491 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412491&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822520 C\C=C(\c1ccc(cc1)C(O)=O)c1ccc(NC(=O)c2cncc(F)c2C)nc1 InChI=1S/C22H18FN3O3/c1-3-17(14-4-6-15(7-5-14)22(28)29)16-8-9-20(25-10-16)26-21(27)18-11-24-12-19(23)13(18)2/h3-12H,1-2H3,(H,28,29)(H,25,26,27)/b17-3- SSFZBDKBNFALSV-YPEHOIGNSA-N 412492 (Z)-4-(1-(6-(5-fluoro-4- methylnicotinamido)pyridin-3- yl)prop-1-en-1-yl)benzoic acid::US10399967, Compound 125 Interleukin-2 1000 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412492 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412492&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822521 C\C=C(/c1cnn(C)c1)c1ccc(NC(=O)c2cncc(F)c2C)nc1 InChI=1S/C19H18FN5O/c1-4-15(14-8-23-25(3)11-14)13-5-6-18(22-7-13)24-19(26)16-9-21-10-17(20)12(16)2/h4-11H,1-3H3,(H,22,24,26)/b15-4- UGMXJALUMJZDKH-TVPGTPATSA-N 412493 (Z)-5-fluoro-4-methyl-N-(5-(1-(1- methyl-1H-pyrazol-4-yl)prop-1-en-1- yl)pyridin-2-yl)nicotinamide::US10399967, Compound 126 Interleukin-2 455 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412493 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412493&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822522 C\C=C(\c1ccc(cc1)S(C)(=O)=O)c1ccc(NC(=O)c2cncc(F)c2C)nc1 InChI=1S/C22H20FN3O3S/c1-4-18(15-5-8-17(9-6-15)30(3,28)29)16-7-10-21(25-11-16)26-22(27)19-12-24-13-20(23)14(19)2/h4-13H,1-3H3,(H,25,26,27)/b18-4- LEDUYFZXYFDBKL-LMXLVEHLSA-N 412494 (Z)-5-fluoro-4-methyl-N-(5-(1-(4- (methylsulfonyl)phenyl)prop-1-en-1- yl)pyridin-2-yl)nicotinamide::US10399967, Compound 127 Interleukin-2 1000 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412494 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412494&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822523 CCC(O)(c1ccc(cc1)S(C)(=O)=O)c1ccc(NC(=O)c2cncc(F)c2C)nc1 InChI=1S/C22H22FN3O4S/c1-4-22(28,15-5-8-17(9-6-15)31(3,29)30)16-7-10-20(25-11-16)26-21(27)18-12-24-13-19(23)14(18)2/h5-13,28H,4H2,1-3H3,(H,25,26,27) NRZFTRYXCGQGFT-UHFFFAOYSA-N 412495 5-fluoro-N-(5-(1-hydroxy-1-(4- (methylsulfonyl)phenyl)propyl) pyridin-2-yl)-4-methylnicotinamide::US10399967, Compound 128 Interleukin-2 1000 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412495&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822524 Cc1cncc(C(=O)Nc2cnc(cn2)-c2cc(ccc2Cl)-c2cnn(C)c2)c1C InChI=1S/C22H19ClN6O/c1-13-7-24-9-18(14(13)2)22(30)28-21-11-25-20(10-26-21)17-6-15(4-5-19(17)23)16-8-27-29(3)12-16/h4-12H,1-3H3,(H,26,28,30) JYJDATAHYXNZAN-UHFFFAOYSA-N 412496 N-(5-(2-chloro-5-(1-methyl-1H- pyrazol-4-yl)phenyl)pyrazin-2-yl)- 4,5-dimethylnicotinamide::US10399967, Compound 129 Interleukin-2 30.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412496&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822525 Cc1ccncc1C(=O)Nc1ccc(cn1)-c1cc(Oc2ncccn2)ccc1Cl InChI=1S/C22H16ClN5O2/c1-14-7-10-24-13-18(14)21(29)28-20-6-3-15(12-27-20)17-11-16(4-5-19(17)23)30-22-25-8-2-9-26-22/h2-13H,1H3,(H,27,28,29) SIOABGSLDWYYEK-UHFFFAOYSA-N 412497 N-(5-(2-chloro-5-(pyrimidin-2- yloxy)phenyl)pyridin-2-yl)-4- methylnicotinamide::US10399967, Compound 130 Interleukin-2 69.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412497&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822526 CCc1cncc(C(=O)Nc2cnc(cn2)-c2cc(ccc2Cl)-c2cnn(C)c2)c1C InChI=1S/C23H21ClN6O/c1-4-15-8-25-10-19(14(15)2)23(31)29-22-12-26-21(11-27-22)18-7-16(5-6-20(18)24)17-9-28-30(3)13-17/h5-13H,4H2,1-3H3,(H,27,29,31) UIYYLDQBKMBMDT-UHFFFAOYSA-N 412498 N-(5-(2-chloro-5-(1-methyl-1H- pyrazol-4-yl)phenyl)pyrazin-2-yl)-5- ethyl-4-methylnicotinamide::US10399967, Compound 131 Interleukin-2 21.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412498 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412498&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822527 Cc1c(cncc1C(=O)Nc1cnc(cn1)-c1cc(ccc1Cl)-c1cnn(C)c1)C#N InChI=1S/C22H16ClN7O/c1-13-15(6-24)7-25-9-18(13)22(31)29-21-11-26-20(10-27-21)17-5-14(3-4-19(17)23)16-8-28-30(2)12-16/h3-5,7-12H,1-2H3,(H,27,29,31) XIWNFRSWTRPDHX-UHFFFAOYSA-N 412499 N-(5-(2-chloro-5-(1-methyl-1H- pyrazol-4-yl)phenyl)pyrazin-2-yl)-5- cyano-4-methylnicotinamide::US10399967, Compound 132 Interleukin-2 77.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412499&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822528 CC(C)=C(c1ccc(O)nc1)c1ccc(NC(=O)c2cncc(F)c2C)nc1 InChI=1S/C21H19FN4O2/c1-12(2)20(15-5-7-19(27)25-9-15)14-4-6-18(24-8-14)26-21(28)16-10-23-11-17(22)13(16)3/h4-11H,1-3H3,(H,25,27)(H,24,26,28) SJXVVNGYKQFEAO-UHFFFAOYSA-N 412500 5-fluoro-N-(5-(1-(6-hydroxypyridin- 3-yl)-2-methylprop-1-en-1- yl)pyridin-2-yl)-4- methylnicotinamide::US10399967, Compound 133 Interleukin-2 1000 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412500&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822529 COc1ccc(cn1)C(=C(C)C)c1ccc(NC(=O)c2cncc(F)c2C)nc1 InChI=1S/C22H21FN4O2/c1-13(2)21(16-6-8-20(29-4)26-10-16)15-5-7-19(25-9-15)27-22(28)17-11-24-12-18(23)14(17)3/h5-12H,1-4H3,(H,25,27,28) XVENRNKCVOMDJB-UHFFFAOYSA-N 412501 5-fluoro-N-(5-(1-(6-methoxypyridin- 3-yl)-2-methylprop-1-en-1- yl)pyridin-2-yl)-4- methylnicotinamide::US10399967, Compound 134 Interleukin-2 63.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412501&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822530 CCC(c1cnn(C)c1)c1ccc(NC(=O)c2cncc(F)c2C)nc1 InChI=1S/C19H20FN5O/c1-4-15(14-8-23-25(3)11-14)13-5-6-18(22-7-13)24-19(26)16-9-21-10-17(20)12(16)2/h5-11,15H,4H2,1-3H3,(H,22,24,26) BJLLFGZDXPERAB-UHFFFAOYSA-N 412502 5-fluoro-4-methyl-N-(5-(1-(1-methyl- 1H-pyrazol-4-yl)propyl)pyridin-2- yl)nicotinamide::US10399967, Compound 135 Interleukin-2 1000 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412502&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822531 C\C=C(\c1ccc(Br)cc1)c1ccc(NC(=O)c2cncc(F)c2C)nc1 InChI=1S/C21H17BrFN3O/c1-3-17(14-4-7-16(22)8-5-14)15-6-9-20(25-10-15)26-21(27)18-11-24-12-19(23)13(18)2/h3-12H,1-2H3,(H,25,26,27)/b17-3- ADJZVZYXLRGJER-YPEHOIGNSA-N 412465 (Z)-N-(5-(1-(4-bromophenyl)prop-1- en-1-yl)pyridin-2-yl)-5-fluoro-4- methylnicotinamide hydrochloride::US10399967, Compound 136::US10399967, Compound 96 Interleukin-2 14.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412465 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412465&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822532 CCc1ccc(Oc2cc(C)on2)cc1-c1cnc(NC(=O)c2cnccc2C)cn1 InChI=1S/C23H21N5O3/c1-4-16-5-6-17(30-22-9-15(3)31-28-22)10-18(16)20-12-26-21(13-25-20)27-23(29)19-11-24-8-7-14(19)2/h5-13H,4H2,1-3H3,(H,26,27,29) MTZGKZJQBAUEBH-UHFFFAOYSA-N 412504 N-(5-(2-ethyl-5-((5-methylisoxazol-3- yl)oxy)phenyl)pyrazin-2-yl)-4- methylnicotinamide::US10399967, Compound 137 Interleukin-2 17.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412504&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822533 CN(C)c1ccc(Cl)c(c1)-c1ccc(NC(=O)c2cnccc2C)nc1 InChI=1S/C20H19ClN4O/c1-13-8-9-22-12-17(13)20(26)24-19-7-4-14(11-23-19)16-10-15(25(2)3)5-6-18(16)21/h4-12H,1-3H3,(H,23,24,26) PGXHYJIFTXXGSH-UHFFFAOYSA-N 412505 N-(5-(2-chloro-5- (dimethylamino)phenyl)pyridin-2- yl)-4-methylnicotinamide::US10399967, Compound 138 Interleukin-2 146 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412505 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412505&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822534 CC(C)Nc1ccc(Cl)c(c1)-c1ccc(NC(=O)c2cnccc2C)nc1 InChI=1S/C21H21ClN4O/c1-13(2)25-16-5-6-19(22)17(10-16)15-4-7-20(24-11-15)26-21(27)18-12-23-9-8-14(18)3/h4-13,25H,1-3H3,(H,24,26,27) UPCODJTVNHSOEI-UHFFFAOYSA-N 412506 N-(5-(2-chloro-5- (isopropylamino)phenyl)pyridin-2- yl)-4-methylnicotinamide::US10399967, Compound 139 Interleukin-2 58.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412506 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412506&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822535 CCOc1ccc(cn1)C(=C\C)\c1ccc(NC(=O)c2cncc(F)c2C)nc1 InChI=1S/C22H21FN4O2/c1-4-17(16-7-9-21(26-11-16)29-5-2)15-6-8-20(25-10-15)27-22(28)18-12-24-13-19(23)14(18)3/h4,6-13H,5H2,1-3H3,(H,25,27,28)/b17-4+ YZGJVFDELAEZDX-HAVNEIBRSA-N 412507 (E)-N-(5-(1-(6-ethoxypyridin-3- yl)prop-1-en-1-yl)pyridin-2-yl)-5- fluoro-4-methylnicotinamide::US10399967, Compound 140 Interleukin-2 25.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412507 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412507&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822536 C\C=C(/c1ccc(NC(=O)c2cncc(F)c2C)nc1)c1ccc(nc1)N1CCCC1 InChI=1S/C24H24FN5O/c1-3-19(18-7-9-23(28-13-18)30-10-4-5-11-30)17-6-8-22(27-12-17)29-24(31)20-14-26-15-21(25)16(20)2/h3,6-9,12-15H,4-5,10-11H2,1-2H3,(H,27,29,31)/b19-3+ PUIWXZWHXRVFJB-QBROUFQSSA-N 412508 (E)-5-fluoro-4-methyl-N-(5-(1-(6- (pyrrolidin-1-yl)pyridin-3-yl)prop-1- en-1-yl)pyridin-2-yl)nicotinamide::US10399967, Compound 141 Interleukin-2 135 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412508 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412508&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822537 Cc1ccncc1C(=O)Nc1cnc(cn1)-c1cc(ccc1Cl)-c1cnn(C)c1 InChI=1S/C21H17ClN6O/c1-13-5-6-23-9-17(13)21(29)27-20-11-24-19(10-25-20)16-7-14(3-4-18(16)22)15-8-26-28(2)12-15/h3-12H,1-2H3,(H,25,27,29) SRHINFVKXQDHJB-UHFFFAOYSA-N 412423 N-(5-(2-chloro-5-(1-methyl-1H- pyrazol-4-yl)phenyl)pyrazin-2-yl)-4- methylnicotinamide::US10399967, Compound 142::US10399967, Compound 53 Interleukin-2 23.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412423 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412423&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822538 Cc1ccc(Oc2ncccc2F)cc1-c1cnc(NC(=O)c2cncc(F)c2C)cn1 InChI=1S/C23H17F2N5O2/c1-13-5-6-15(32-23-18(24)4-3-7-27-23)8-16(13)20-11-29-21(12-28-20)30-22(31)17-9-26-10-19(25)14(17)2/h3-12H,1-2H3,(H,29,30,31) GVRPMKMPHLFNQQ-UHFFFAOYSA-N 412510 5-fluoro-N-(5-(5-((3-fluoropyridin-2- yl)oxy)-2-methylphenyl)pyrazin-2- yl)-4-methylnicotinamide::US10399967, Compound 143 Interleukin-2 35.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412510 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412510&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822539 CC(C)Oc1ccc(Cl)c(c1)-c1cnc(NC(=O)c2cnccc2C)cn1 InChI=1S/C20H19ClN4O2/c1-12(2)27-14-4-5-17(21)15(8-14)18-10-24-19(11-23-18)25-20(26)16-9-22-7-6-13(16)3/h4-12H,1-3H3,(H,24,25,26) RECUGCPDVPFHMP-UHFFFAOYSA-N 412511 N-(5-(2-chloro-5- isopropoxyphenyl)pyrazin-2-yl)-4- methylnicotinamide::US10399967, Compound 144 Interleukin-2 13.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412511 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412511&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822540 C\C=C(\c1ccc(cc1)-c1cnn(C)c1)c1ccc(NC(=O)c2cncc(F)c2C)nc1 InChI=1S/C25H22FN5O/c1-4-21(18-7-5-17(6-8-18)20-12-29-31(3)15-20)19-9-10-24(28-11-19)30-25(32)22-13-27-14-23(26)16(22)2/h4-15H,1-3H3,(H,28,30,32)/b21-4- KPAILJMSVFUPDF-IGLQUIOVSA-N 412478 (Z)-5-fluoro-4-methyl-N-(5-(1-(4-(1- methyl-1H-pyrazol-4- yl)phenyl)prop-1-en-1-yl)pyridin-2- yl)nicotinamide::US10399967, Compound 111::US10399967, Compound 145 Interleukin-2 118 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412478 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412478&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 822541 C\C=C(\c1ccc(Br)cc1)c1cnc(NC(=O)c2cncc(F)c2C)cn1 InChI=1S/C20H16BrFN4O/c1-3-15(13-4-6-14(21)7-5-13)18-10-25-19(11-24-18)26-20(27)16-8-23-9-17(22)12(16)2/h3-11H,1-2H3,(H,25,26,27)/b15-3- LPNGUNKXNPYWTD-CQPUUCJISA-N 412513 (Z)-N-(5-(1-(4-bromophenyl)prop-1- en-1-yl)pyrazin-2-yl)-5-fluoro-4- methylnicotinamide::US10399967, Compound 146 Interleukin-2 18.0 US Patent 10.7270/Q2Z89FRQ aid1803794 US10399967 Chen, S; Bohnert, G; Jiang, J; Xia, Z PRCL RESEARCH INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412513 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412513&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51187553 NC(N)=N[C@H](C1CCCCC1)C(=O)NCC(=O)N1CCC(CC1)c1cc(n[nH]1)-c1cccc(Cl)c1Cl InChI=1S/C25H33Cl2N7O2/c26-18-8-4-7-17(22(18)27)20-13-19(32-33-20)15-9-11-34(12-10-15)21(35)14-30-24(36)23(31-25(28)29)16-5-2-1-3-6-16/h4,7-8,13,15-16,23H,1-3,5-6,9-12,14H2,(H,30,36)(H,32,33)(H4,28,29,31)/t23-/m1/s1 SSSXBBASYYVGCI-HSZRJFAPSA-N 50148008 (R)-2-Cyclohexyl-N-(2-{4-[5-(2,3-dichloro-phenyl)-2H-pyrazol-3-yl]-piperidin-1-yl}-2-oxo-ethyl)-2-guanidino-acetamide::2-(R)-Cyclohexyl-N-(2-{4-[5-(2,3-dichloro-phenyl)-2H-pyrazol-3-yl]-piperidin-1-yl}-2-oxo-ethyl)-2-guanidino-acetamide::2-CYCLOHEXYL-N-(2-{4-[5-(2,3-DICHLORO-PHENYL)-2H-PYRAZOL-3-YL]-PIPERIDIN-1-YL}-2-OXO-ETHYL)-2-GUANIDINO-ACETAMIDE::CHEMBL106187 Interleukin-2 6000 ChEMBL 10.1007/s00044-013-0564-x 10.7270/Q20V8GP1 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50148008 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50148008&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 447945 104036413 CHEMBL106187 ZINC14880973 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51187555 CC(C)CC([NH+]=C(N)N)C(=O)NCC(=O)N1CCC(CC1)c1cc(nn1C)-c1ccc(OCc2ccc(o2)C([O-])=O)c(Cl)c1Cl InChI=1S/C30H37Cl2N7O6/c1-16(2)12-21(36-30(33)34)28(41)35-14-25(40)39-10-8-17(9-11-39)22-13-20(37-38(22)3)19-5-7-23(27(32)26(19)31)44-15-18-4-6-24(45-18)29(42)43/h4-7,13,16-17,21H,8-12,14-15H2,1-3H3,(H,35,41)(H,42,43)(H4,33,34,36) VNZHOIDQBPFEJU-UHFFFAOYSA-N 50229786 5-[2,3-DICHLORO-4-(5-{1-[2-(2-GUANIDINO-4-METHYL-PENTANOYLAMINO)-ACETYL]-PIPERIDIN-4-YL}-1-METHYL-1H-PYRAZOL-3-YL)-PHENOXYMETHYL]-FURAN-2-CARBOXYLIC ACID::5-[2,3-Dichloro-4-(5-{1-[2-((R)-2-guanidino-4-methyl-1-oxo-pentylamino)-acetyl]-piperidin-4-yl}-1-methyl-1H-pyrazol-3-yl)-phenoxymethyl]-furan-2-carboxylic acid::5-[2,3-Dichloro-4-(5-{1-[2-((R)-2-guanidino-4-methyl-pentanoylamino)-acetyl]-piperidin-4-yl}-1-methyl-1H-pyrazol-3-yl)-phenoxymethyl]-furan-2-carboxylic acid::CHEMBL429852::SP-4206 Interleukin-2 60 ChEMBL 10.1007/s00044-013-0564-x 10.7270/Q20V8GP1 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50229786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50229786&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 91935514 104098213 47417 CHEMBL429852 ZINC03990365 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51311847 CCCC#Cc1ccc(C[C@@H](NC(=O)CCn2c(C)cc3ccccc23)C(O)=O)cc1 InChI=1S/C26H28N2O3/c1-3-4-5-8-20-11-13-21(14-12-20)18-23(26(30)31)27-25(29)15-16-28-19(2)17-22-9-6-7-10-24(22)28/h6-7,9-14,17,23H,3-4,15-16,18H2,1-2H3,(H,27,29)(H,30,31)/t23-/m1/s1 WSSGSQIUQXAMLX-HSZRJFAPSA-N 50532281 CHEMBL4515387 Interleukin-2 4200 ChEMBL 10.1021/acs.jmedchem.5b01874 10.7270/Q2N58QV5 26914744 Franzini, RM; Randolph, C University of Utah http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532281&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 155539721 440740863 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51311852 CCCC#Cc1ccc(C[C@@H](NC(=O)CCn2c(C)cc3ccccc23)C(O)=O)cc1 InChI=1S/C26H28N2O3/c1-3-4-5-8-20-11-13-21(14-12-20)18-23(26(30)31)27-25(29)15-16-28-19(2)17-22-9-6-7-10-24(22)28/h6-7,9-14,17,23H,3-4,15-16,18H2,1-2H3,(H,27,29)(H,30,31)/t23-/m1/s1 WSSGSQIUQXAMLX-HSZRJFAPSA-N 50532281 CHEMBL4515387 Interleukin-2 4200 ChEMBL 10.1021/acs.jmedchem.5b01874 10.7270/Q2N58QV5 26914744 Franzini, RM; Randolph, C University of Utah http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532281&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 155539721 440740863 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51413760 Cn1c(Cc2nn(C)c(=O)c3ccccc23)nnc1SCC(=O)Nc1ccc(Cl)cc1Cl InChI=1S/C21H18Cl2N6O2S/c1-28-18(10-17-13-5-3-4-6-14(13)20(31)29(2)27-17)25-26-21(28)32-11-19(30)24-16-8-7-12(22)9-15(16)23/h3-9H,10-11H2,1-2H3,(H,24,30) RUZXXRYUPQCFAF-UHFFFAOYSA-N 50238648 CHEMBL4102828 Interleukin-2 7700 ChEMBL 10.1016/j.bmc.2021.116161 10.7270/Q2FF3X47 33932805 Smadja, J; Quéméner, A; Maillasson, M; Sicard, B; Leray, A; Arzel, L; Lebreton, J; Mortier, E; Dubreuil, D; Mathé-Allainmat, M Universit£ de Nantes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50238648 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50238648&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 44449911 85716730 CHEMBL4102828 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51413761 CCOC(CCn1c(Cc2nn(C)c(=O)c3ccccc23)nnc1SCC(=O)Nc1ccc(Cl)cc1Cl)OCC InChI=1S/C27H30Cl2N6O4S/c1-4-38-25(39-5-2)12-13-35-23(15-22-18-8-6-7-9-19(18)26(37)34(3)33-22)31-32-27(35)40-16-24(36)30-21-11-10-17(28)14-20(21)29/h6-11,14,25H,4-5,12-13,15-16H2,1-3H3,(H,30,36) PBCQBGMZGHYFPR-UHFFFAOYSA-N 50571040 CHEMBL4867872 Interleukin-2 >30000 ChEMBL 10.1016/j.bmc.2021.116161 10.7270/Q2FF3X47 33932805 Smadja, J; Quéméner, A; Maillasson, M; Sicard, B; Leray, A; Arzel, L; Lebreton, J; Mortier, E; Dubreuil, D; Mathé-Allainmat, M Universit£ de Nantes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50571040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50571040&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 164619725 471061185 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51413762 Cn1nc(Cc2nnc(SCC(=O)Nc3ccc(Cl)cc3Cl)n2CCC=O)c2ccccc2c1=O InChI=1S/C23H20Cl2N6O3S/c1-30-22(34)16-6-3-2-5-15(16)19(29-30)12-20-27-28-23(31(20)9-4-10-32)35-13-21(33)26-18-8-7-14(24)11-17(18)25/h2-3,5-8,10-11H,4,9,12-13H2,1H3,(H,26,33) OURYKCRLLYNLDL-UHFFFAOYSA-N 50571041 CHEMBL4864820 Interleukin-2 8600 ChEMBL 10.1016/j.bmc.2021.116161 10.7270/Q2FF3X47 33932805 Smadja, J; Quéméner, A; Maillasson, M; Sicard, B; Leray, A; Arzel, L; Lebreton, J; Mortier, E; Dubreuil, D; Mathé-Allainmat, M Universit£ de Nantes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50571041 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50571041&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 164625530 471061186 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51413763 Cn1nc(Cc2nnc(SCC(=O)Nc3ccc(Cl)cc3Cl)n2CCCO)c2ccccc2c1=O InChI=1S/C23H22Cl2N6O3S/c1-30-22(34)16-6-3-2-5-15(16)19(29-30)12-20-27-28-23(31(20)9-4-10-32)35-13-21(33)26-18-8-7-14(24)11-17(18)25/h2-3,5-8,11,32H,4,9-10,12-13H2,1H3,(H,26,33) CNUYNTXJWXSAFC-UHFFFAOYSA-N 50571042 CHEMBL4849548 Interleukin-2 >30000 ChEMBL 10.1016/j.bmc.2021.116161 10.7270/Q2FF3X47 33932805 Smadja, J; Quéméner, A; Maillasson, M; Sicard, B; Leray, A; Arzel, L; Lebreton, J; Mortier, E; Dubreuil, D; Mathé-Allainmat, M Universit£ de Nantes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50571042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50571042&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 164614949 471061187 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51413764 Cn1nc(Cc2nnc(SCC(=O)Nc3ccc(Cl)cc3Cl)n2CCC(O)=O)c2ccccc2c1=O InChI=1S/C23H20Cl2N6O4S/c1-30-22(35)15-5-3-2-4-14(15)18(29-30)11-19-27-28-23(31(19)9-8-21(33)34)36-12-20(32)26-17-7-6-13(24)10-16(17)25/h2-7,10H,8-9,11-12H2,1H3,(H,26,32)(H,33,34) JEZOOVPTFQSPQG-UHFFFAOYSA-N 50571043 CHEMBL4857570 Interleukin-2 >30000 ChEMBL 10.1016/j.bmc.2021.116161 10.7270/Q2FF3X47 33932805 Smadja, J; Quéméner, A; Maillasson, M; Sicard, B; Leray, A; Arzel, L; Lebreton, J; Mortier, E; Dubreuil, D; Mathé-Allainmat, M Universit£ de Nantes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50571043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50571043&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 164611415 471061188 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51413765 Cn1c(Cc2nn(CCC3OCCO3)c(=O)c3ccccc23)nnc1SCC(=O)Nc1ccc(Cl)cc1Cl InChI=1S/C25H24Cl2N6O4S/c1-32-21(29-30-25(32)38-14-22(34)28-19-7-6-15(26)12-18(19)27)13-20-16-4-2-3-5-17(16)24(35)33(31-20)9-8-23-36-10-11-37-23/h2-7,12,23H,8-11,13-14H2,1H3,(H,28,34) CAOVIZSTZKNRMK-UHFFFAOYSA-N 50571044 CHEMBL4878149 Interleukin-2 >30000 ChEMBL 10.1016/j.bmc.2021.116161 10.7270/Q2FF3X47 33932805 Smadja, J; Quéméner, A; Maillasson, M; Sicard, B; Leray, A; Arzel, L; Lebreton, J; Mortier, E; Dubreuil, D; Mathé-Allainmat, M Universit£ de Nantes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50571044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50571044&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 164627105 471061189 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51413766 Cn1c(Cc2nn(CCC=O)c(=O)c3ccccc23)nnc1SCC(=O)Nc1ccc(Cl)cc1Cl InChI=1S/C23H20Cl2N6O3S/c1-30-20(12-19-15-5-2-3-6-16(15)22(34)31(29-19)9-4-10-32)27-28-23(30)35-13-21(33)26-18-8-7-14(24)11-17(18)25/h2-3,5-8,10-11H,4,9,12-13H2,1H3,(H,26,33) UHIYFTCVVSBNTC-UHFFFAOYSA-N 50571045 CHEMBL4848978 Interleukin-2 >30000 ChEMBL 10.1016/j.bmc.2021.116161 10.7270/Q2FF3X47 33932805 Smadja, J; Quéméner, A; Maillasson, M; Sicard, B; Leray, A; Arzel, L; Lebreton, J; Mortier, E; Dubreuil, D; Mathé-Allainmat, M Universit£ de Nantes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50571045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50571045&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 164614391 471061190 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51413767 Cn1c(Cc2nn(CCCO)c(=O)c3ccccc23)nnc1SCC(=O)Nc1ccc(Cl)cc1Cl InChI=1S/C23H22Cl2N6O3S/c1-30-20(12-19-15-5-2-3-6-16(15)22(34)31(29-19)9-4-10-32)27-28-23(30)35-13-21(33)26-18-8-7-14(24)11-17(18)25/h2-3,5-8,11,32H,4,9-10,12-13H2,1H3,(H,26,33) HDAVYAJNOJTKBR-UHFFFAOYSA-N 50571046 CHEMBL4875914 Interleukin-2 >30000 ChEMBL 10.1016/j.bmc.2021.116161 10.7270/Q2FF3X47 33932805 Smadja, J; Quéméner, A; Maillasson, M; Sicard, B; Leray, A; Arzel, L; Lebreton, J; Mortier, E; Dubreuil, D; Mathé-Allainmat, M Universit£ de Nantes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50571046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50571046&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 164628505 471061191 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51413768 Cn1c(Cc2nn(CCC(O)=O)c(=O)c3ccccc23)nnc1SCC(=O)Nc1ccc(Cl)cc1Cl InChI=1S/C23H20Cl2N6O4S/c1-30-19(27-28-23(30)36-12-20(32)26-17-7-6-13(24)10-16(17)25)11-18-14-4-2-3-5-15(14)22(35)31(29-18)9-8-21(33)34/h2-7,10H,8-9,11-12H2,1H3,(H,26,32)(H,33,34) SOQAUGHQJYSXNC-UHFFFAOYSA-N 50571047 CHEMBL4856031 Interleukin-2 >30000 ChEMBL 10.1016/j.bmc.2021.116161 10.7270/Q2FF3X47 33932805 Smadja, J; Quéméner, A; Maillasson, M; Sicard, B; Leray, A; Arzel, L; Lebreton, J; Mortier, E; Dubreuil, D; Mathé-Allainmat, M Universit£ de Nantes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50571047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50571047&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 164609716 471061192 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51413769 CN(C)CCCn1nc(Cc2nnc(SCC(=O)Nc3ccc(Cl)cc3Cl)n2C)c2ccccc2c1=O InChI=1S/C25H27Cl2N7O2S/c1-32(2)11-6-12-34-24(36)18-8-5-4-7-17(18)21(31-34)14-22-29-30-25(33(22)3)37-15-23(35)28-20-10-9-16(26)13-19(20)27/h4-5,7-10,13H,6,11-12,14-15H2,1-3H3,(H,28,35) WCIVEKHHJRXVMF-UHFFFAOYSA-N 50571048 CHEMBL4849059 Interleukin-2 >30000 ChEMBL 10.1016/j.bmc.2021.116161 10.7270/Q2FF3X47 33932805 Smadja, J; Quéméner, A; Maillasson, M; Sicard, B; Leray, A; Arzel, L; Lebreton, J; Mortier, E; Dubreuil, D; Mathé-Allainmat, M Universit£ de Nantes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50571048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50571048&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 164616661 471061193 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51413770 Cn1c(Cc2nn(C)c(=O)c3ccccc23)nnc1SCCCCCCCC(=O)Nc1ccc(Cl)cc1Cl InChI=1S/C27H30Cl2N6O2S/c1-34-24(17-23-19-10-7-8-11-20(19)26(37)35(2)33-23)31-32-27(34)38-15-9-5-3-4-6-12-25(36)30-22-14-13-18(28)16-21(22)29/h7-8,10-11,13-14,16H,3-6,9,12,15,17H2,1-2H3,(H,30,36) DDNCGNPWKAPRTO-UHFFFAOYSA-N 50238649 CHEMBL4103753 Interleukin-2 350 ChEMBL 10.1016/j.bmc.2021.116161 10.7270/Q2FF3X47 33932805 Smadja, J; Quéméner, A; Maillasson, M; Sicard, B; Leray, A; Arzel, L; Lebreton, J; Mortier, E; Dubreuil, D; Mathé-Allainmat, M Universit£ de Nantes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50238649 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50238649&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 44450154 85717089 CHEMBL4103753 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51413771 CCOC(CCn1c(Cc2nn(C)c(=O)c3ccccc23)nnc1SCCCCCCCC(=O)Nc1ccc(Cl)cc1Cl)OCC InChI=1S/C33H42Cl2N6O4S/c1-4-44-31(45-5-2)18-19-41-29(22-28-24-13-10-11-14-25(24)32(43)40(3)39-28)37-38-33(41)46-20-12-8-6-7-9-15-30(42)36-27-17-16-23(34)21-26(27)35/h10-11,13-14,16-17,21,31H,4-9,12,15,18-20,22H2,1-3H3,(H,36,42) MOQJVBRGSNZSKG-UHFFFAOYSA-N 50571049 CHEMBL4868024 Interleukin-2 >30000 ChEMBL 10.1016/j.bmc.2021.116161 10.7270/Q2FF3X47 33932805 Smadja, J; Quéméner, A; Maillasson, M; Sicard, B; Leray, A; Arzel, L; Lebreton, J; Mortier, E; Dubreuil, D; Mathé-Allainmat, M Universit£ de Nantes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50571049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50571049&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 164625130 471061194 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51413772 Cn1nc(Cc2nnc(SCCCCCCCC(=O)Nc3ccc(Cl)cc3Cl)n2CCC=O)c2ccccc2c1=O InChI=1S/C29H32Cl2N6O3S/c1-36-28(40)22-11-7-6-10-21(22)25(35-36)19-26-33-34-29(37(26)15-9-16-38)41-17-8-4-2-3-5-12-27(39)32-24-14-13-20(30)18-23(24)31/h6-7,10-11,13-14,16,18H,2-5,8-9,12,15,17,19H2,1H3,(H,32,39) BKWOFDJZGMDOEV-UHFFFAOYSA-N 50571050 CHEMBL4851186 Interleukin-2 960 ChEMBL 10.1016/j.bmc.2021.116161 10.7270/Q2FF3X47 33932805 Smadja, J; Quéméner, A; Maillasson, M; Sicard, B; Leray, A; Arzel, L; Lebreton, J; Mortier, E; Dubreuil, D; Mathé-Allainmat, M Universit£ de Nantes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50571050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50571050&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 164618410 471061195 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51413773 Cn1nc(Cc2nnc(SCCCCCCCC(=O)Nc3ccc(Cl)cc3Cl)[nH]2)c2ccccc2c1=O InChI=1S/C26H28Cl2N6O2S/c1-34-25(36)19-10-7-6-9-18(19)22(33-34)16-23-30-26(32-31-23)37-14-8-4-2-3-5-11-24(35)29-21-13-12-17(27)15-20(21)28/h6-7,9-10,12-13,15H,2-5,8,11,14,16H2,1H3,(H,29,35)(H,30,31,32) HIZARHQUDAMZGG-UHFFFAOYSA-N 50571051 CHEMBL4846844 Interleukin-2 450 ChEMBL 10.1016/j.bmc.2021.116161 10.7270/Q2FF3X47 33932805 Smadja, J; Quéméner, A; Maillasson, M; Sicard, B; Leray, A; Arzel, L; Lebreton, J; Mortier, E; Dubreuil, D; Mathé-Allainmat, M Universit£ de Nantes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50571051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50571051&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 164608756 471061196 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51413774 Cn1nc(Cc2nnc(SCCCCCCCC(=O)Nc3ccc(Cl)cc3Cl)n2CCCO[Si](C)(C)C(C)(C)C)c2ccccc2c1=O InChI=1S/C35H48Cl2N6O3SSi/c1-35(2,3)48(5,6)46-21-14-20-43-31(24-30-26-15-11-12-16-27(26)33(45)42(4)41-30)39-40-34(43)47-22-13-9-7-8-10-17-32(44)38-29-19-18-25(36)23-28(29)37/h11-12,15-16,18-19,23H,7-10,13-14,17,20-22,24H2,1-6H3,(H,38,44) MZIJQTGOQIVPQH-UHFFFAOYSA-N 50571052 CHEMBL4869889 Interleukin-2 >30000 ChEMBL 10.1016/j.bmc.2021.116161 10.7270/Q2FF3X47 33932805 Smadja, J; Quéméner, A; Maillasson, M; Sicard, B; Leray, A; Arzel, L; Lebreton, J; Mortier, E; Dubreuil, D; Mathé-Allainmat, M Universit£ de Nantes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50571052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50571052&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 164618543 471061197 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51413775 Cn1nc(Cc2nnc(SCCCCCCCC(=O)Nc3ccc(Cl)cc3Cl)n2CCCO)c2ccccc2c1=O InChI=1S/C29H34Cl2N6O3S/c1-36-28(40)22-11-7-6-10-21(22)25(35-36)19-26-33-34-29(37(26)15-9-16-38)41-17-8-4-2-3-5-12-27(39)32-24-14-13-20(30)18-23(24)31/h6-7,10-11,13-14,18,38H,2-5,8-9,12,15-17,19H2,1H3,(H,32,39) NQJHCUOBIRIISX-UHFFFAOYSA-N 50571053 CHEMBL4858180 Interleukin-2 >30000 ChEMBL 10.1016/j.bmc.2021.116161 10.7270/Q2FF3X47 33932805 Smadja, J; Quéméner, A; Maillasson, M; Sicard, B; Leray, A; Arzel, L; Lebreton, J; Mortier, E; Dubreuil, D; Mathé-Allainmat, M Universit£ de Nantes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50571053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50571053&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 164610930 471061198 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51413776 Cn1nc(Cc2nnc(SCCCCCCCC(=O)Nc3ccc(Cl)cc3Cl)n2CCC(O)=O)c2ccccc2c1=O InChI=1S/C29H32Cl2N6O4S/c1-36-28(41)21-10-7-6-9-20(21)24(35-36)18-25-33-34-29(37(25)15-14-27(39)40)42-16-8-4-2-3-5-11-26(38)32-23-13-12-19(30)17-22(23)31/h6-7,9-10,12-13,17H,2-5,8,11,14-16,18H2,1H3,(H,32,38)(H,39,40) APRYGLLMCLFANI-UHFFFAOYSA-N 50571054 CHEMBL4864898 Interleukin-2 14300 ChEMBL 10.1016/j.bmc.2021.116161 10.7270/Q2FF3X47 33932805 Smadja, J; Quéméner, A; Maillasson, M; Sicard, B; Leray, A; Arzel, L; Lebreton, J; Mortier, E; Dubreuil, D; Mathé-Allainmat, M Universit£ de Nantes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50571054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50571054&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 164620046 471061199 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51413777 CN(C)CCCn1c(Cc2nn(C)c(=O)c3ccccc23)nnc1SCCCCCCCC(=O)Nc1ccc(Cl)cc1Cl InChI=1S/C31H39Cl2N7O2S/c1-38(2)17-11-18-40-28(21-27-23-12-8-9-13-24(23)30(42)39(3)37-27)35-36-31(40)43-19-10-6-4-5-7-14-29(41)34-26-16-15-22(32)20-25(26)33/h8-9,12-13,15-16,20H,4-7,10-11,14,17-19,21H2,1-3H3,(H,34,41) KSCYGLQJYYKMIV-UHFFFAOYSA-N 50571055 CHEMBL4878834 Interleukin-2 >30000 ChEMBL 10.1016/j.bmc.2021.116161 10.7270/Q2FF3X47 33932805 Smadja, J; Quéméner, A; Maillasson, M; Sicard, B; Leray, A; Arzel, L; Lebreton, J; Mortier, E; Dubreuil, D; Mathé-Allainmat, M Universit£ de Nantes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50571055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50571055&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 164626248 471061200 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51413778 Cn1c(Cc2nn(CCCO[Si](C)(C)C(C)(C)C)c(=O)c3ccccc23)nnc1SCCCCCCCC(=O)Nc1ccc(Cl)cc1Cl InChI=1S/C35H48Cl2N6O3SSi/c1-35(2,3)48(5,6)46-21-14-20-43-33(45)27-16-12-11-15-26(27)30(41-43)24-31-39-40-34(42(31)4)47-22-13-9-7-8-10-17-32(44)38-29-19-18-25(36)23-28(29)37/h11-12,15-16,18-19,23H,7-10,13-14,17,20-22,24H2,1-6H3,(H,38,44) UWFBQOBRCWVTNY-UHFFFAOYSA-N 50571056 CHEMBL4863838 Interleukin-2 >30000 ChEMBL 10.1016/j.bmc.2021.116161 10.7270/Q2FF3X47 33932805 Smadja, J; Quéméner, A; Maillasson, M; Sicard, B; Leray, A; Arzel, L; Lebreton, J; Mortier, E; Dubreuil, D; Mathé-Allainmat, M Universit£ de Nantes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50571056 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50571056&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 164619172 471061201 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51413779 Cn1c(Cc2nn(CCC=O)c(=O)c3ccccc23)nnc1SCCCCCCCC(=O)Nc1ccc(Cl)cc1Cl InChI=1S/C29H32Cl2N6O3S/c1-36-26(19-25-21-10-6-7-11-22(21)28(40)37(35-25)15-9-16-38)33-34-29(36)41-17-8-4-2-3-5-12-27(39)32-24-14-13-20(30)18-23(24)31/h6-7,10-11,13-14,16,18H,2-5,8-9,12,15,17,19H2,1H3,(H,32,39) OOPJYDONKJPGOM-UHFFFAOYSA-N 50571057 CHEMBL4847472 Interleukin-2 21900 ChEMBL 10.1016/j.bmc.2021.116161 10.7270/Q2FF3X47 33932805 Smadja, J; Quéméner, A; Maillasson, M; Sicard, B; Leray, A; Arzel, L; Lebreton, J; Mortier, E; Dubreuil, D; Mathé-Allainmat, M Universit£ de Nantes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50571057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50571057&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 164614862 471061202 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51413780 Cn1c(Cc2nn(CCCO)c(=O)c3ccccc23)nnc1SCCCCCCCC(=O)Nc1ccc(Cl)cc1Cl InChI=1S/C29H34Cl2N6O3S/c1-36-26(19-25-21-10-6-7-11-22(21)28(40)37(35-25)15-9-16-38)33-34-29(36)41-17-8-4-2-3-5-12-27(39)32-24-14-13-20(30)18-23(24)31/h6-7,10-11,13-14,18,38H,2-5,8-9,12,15-17,19H2,1H3,(H,32,39) FZMKBJNQMQEJQO-UHFFFAOYSA-N 50571058 CHEMBL4852416 Interleukin-2 >30000 ChEMBL 10.1016/j.bmc.2021.116161 10.7270/Q2FF3X47 33932805 Smadja, J; Quéméner, A; Maillasson, M; Sicard, B; Leray, A; Arzel, L; Lebreton, J; Mortier, E; Dubreuil, D; Mathé-Allainmat, M Universit£ de Nantes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50571058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50571058&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 164616787 471061203 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51413781 Cn1c(Cc2nn(CCC(O)=O)c(=O)c3ccccc23)nnc1SCCCCCCCC(=O)Nc1ccc(Cl)cc1Cl InChI=1S/C29H32Cl2N6O4S/c1-36-25(18-24-20-9-6-7-10-21(20)28(41)37(35-24)15-14-27(39)40)33-34-29(36)42-16-8-4-2-3-5-11-26(38)32-23-13-12-19(30)17-22(23)31/h6-7,9-10,12-13,17H,2-5,8,11,14-16,18H2,1H3,(H,32,38)(H,39,40) BUJOWFVQKSZAON-UHFFFAOYSA-N 50571059 CHEMBL4877071 Interleukin-2 30000 ChEMBL 10.1016/j.bmc.2021.116161 10.7270/Q2FF3X47 33932805 Smadja, J; Quéméner, A; Maillasson, M; Sicard, B; Leray, A; Arzel, L; Lebreton, J; Mortier, E; Dubreuil, D; Mathé-Allainmat, M Universit£ de Nantes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50571059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50571059&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 164628263 471061204 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51413782 CN(C)CCCn1nc(Cc2nnc(SCCCCCCCC(=O)Nc3ccc(Cl)cc3Cl)n2C)c2ccccc2c1=O InChI=1S/C31H39Cl2N7O2S/c1-38(2)17-11-18-40-30(42)24-13-9-8-12-23(24)27(37-40)21-28-35-36-31(39(28)3)43-19-10-6-4-5-7-14-29(41)34-26-16-15-22(32)20-25(26)33/h8-9,12-13,15-16,20H,4-7,10-11,14,17-19,21H2,1-3H3,(H,34,41) WSSZFFYJMSHQBH-UHFFFAOYSA-N 50571060 CHEMBL4862957 Interleukin-2 >30000 ChEMBL 10.1016/j.bmc.2021.116161 10.7270/Q2FF3X47 33932805 Smadja, J; Quéméner, A; Maillasson, M; Sicard, B; Leray, A; Arzel, L; Lebreton, J; Mortier, E; Dubreuil, D; Mathé-Allainmat, M Universit£ de Nantes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50571060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50571060&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 164625462 471061205 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51413783 Cn1c(Cc2n[nH]c(=O)c3ccccc23)nnc1SCCCCCCCC(=O)Nc1ccc(Cl)cc1Cl InChI=1S/C26H28Cl2N6O2S/c1-34-23(16-22-18-9-6-7-10-19(18)25(36)32-30-22)31-33-26(34)37-14-8-4-2-3-5-11-24(35)29-21-13-12-17(27)15-20(21)28/h6-7,9-10,12-13,15H,2-5,8,11,14,16H2,1H3,(H,29,35)(H,32,36) ONGBBHLBRUCXOK-UHFFFAOYSA-N 50571061 CHEMBL4861648 Interleukin-2 >30000 ChEMBL 10.1016/j.bmc.2021.116161 10.7270/Q2FF3X47 33932805 Smadja, J; Quéméner, A; Maillasson, M; Sicard, B; Leray, A; Arzel, L; Lebreton, J; Mortier, E; Dubreuil, D; Mathé-Allainmat, M Universit£ de Nantes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50571061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50571061&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 164613678 471061206 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51413784 Cn1c(Cc2nn(C)c(=O)c3ccccc23)nnc1SCCCCCCCC(=O)Nc1ccc(cc1)C(=O)c1ccccc1 InChI=1S/C34H36N6O3S/c1-39-30(23-29-27-15-10-11-16-28(27)33(43)40(2)38-29)36-37-34(39)44-22-12-5-3-4-9-17-31(41)35-26-20-18-25(19-21-26)32(42)24-13-7-6-8-14-24/h6-8,10-11,13-16,18-21H,3-5,9,12,17,22-23H2,1-2H3,(H,35,41) JDWUULUXEHZPNW-UHFFFAOYSA-N 50571062 CHEMBL4857666 Interleukin-2 80 ChEMBL 10.1016/j.bmc.2021.116161 10.7270/Q2FF3X47 33932805 Smadja, J; Quéméner, A; Maillasson, M; Sicard, B; Leray, A; Arzel, L; Lebreton, J; Mortier, E; Dubreuil, D; Mathé-Allainmat, M Universit£ de Nantes http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50571062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50571062&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 164614710 471061207 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51423673 OC(=O)[C@H](Cc1ccc(O)c(I)c1)NC(=O)c1cc2c(F)cccc2[nH]1 50575304 CHEMBL4877313 Interleukin-2 250 ChEMBL 10.1021/acs.jmedchem.1c01693 10.7270/Q2H135TK 34821503 Gironda-Martínez, A; Gorre, ÉMD; Prati, L; Gosalbes, JF; Dakhel, S; Cazzamalli, S; Samain, F; Donckele, EJ; Neri, D Philochem AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50575304 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50575304&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 164629162 471065449 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51423674 OC(=O)[C@@H](Cc1ccc(O)c(I)c1)NC(=O)c1cc2c(F)cccc2[nH]1 50575305 CHEMBL4866037 Interleukin-2 210 ChEMBL 10.1021/acs.jmedchem.1c01693 10.7270/Q2H135TK 34821503 Gironda-Martínez, A; Gorre, ÉMD; Prati, L; Gosalbes, JF; Dakhel, S; Cazzamalli, S; Samain, F; Donckele, EJ; Neri, D Philochem AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50575305 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50575305&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 164618817 471065450 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51423675 OC(=O)[C@H](Cc1ccc(O)c(Br)c1)NC(=O)c1cc2c(F)cccc2[nH]1 50575306 CHEMBL4855828 Interleukin-2 300 ChEMBL 10.1021/acs.jmedchem.1c01693 10.7270/Q2H135TK 34821503 Gironda-Martínez, A; Gorre, ÉMD; Prati, L; Gosalbes, JF; Dakhel, S; Cazzamalli, S; Samain, F; Donckele, EJ; Neri, D Philochem AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50575306 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50575306&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 164609700 471065451 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51423676 OC(=O)[C@H](Cc1ccc(O)c(Cl)c1)NC(=O)c1cc2c(F)cccc2[nH]1 50575307 CHEMBL4873867 Interleukin-2 590 ChEMBL 10.1021/acs.jmedchem.1c01693 10.7270/Q2H135TK 34821503 Gironda-Martínez, A; Gorre, ÉMD; Prati, L; Gosalbes, JF; Dakhel, S; Cazzamalli, S; Samain, F; Donckele, EJ; Neri, D Philochem AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50575307 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50575307&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 164619892 471065452 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51423677 OC(=O)[C@H](Cc1ccc(O)c(F)c1)NC(=O)c1cc2c(F)cccc2[nH]1 50575308 CHEMBL4872601 Interleukin-2 920 ChEMBL 10.1021/acs.jmedchem.1c01693 10.7270/Q2H135TK 34821503 Gironda-Martínez, A; Gorre, ÉMD; Prati, L; Gosalbes, JF; Dakhel, S; Cazzamalli, S; Samain, F; Donckele, EJ; Neri, D Philochem AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50575308 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50575308&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 164624339 471065453 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51423678 OC(=O)[C@H](Cc1ccc(O)c(c1)[N+]([O-])=O)NC(=O)c1cc2c(F)cccc2[nH]1 50575309 CHEMBL4856339 Interleukin-2 720 ChEMBL 10.1021/acs.jmedchem.1c01693 10.7270/Q2H135TK 34821503 Gironda-Martínez, A; Gorre, ÉMD; Prati, L; Gosalbes, JF; Dakhel, S; Cazzamalli, S; Samain, F; Donckele, EJ; Neri, D Philochem AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50575309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50575309&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 164610280 471065454 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51423679 COc1ccc(C[C@H](NC(=O)c2cc3c(F)cccc3[nH]2)C(O)=O)cc1 50575310 CHEMBL4879282 Interleukin-2 1300 ChEMBL 10.1021/acs.jmedchem.1c01693 10.7270/Q2H135TK 34821503 Gironda-Martínez, A; Gorre, ÉMD; Prati, L; Gosalbes, JF; Dakhel, S; Cazzamalli, S; Samain, F; Donckele, EJ; Neri, D Philochem AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50575310 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50575310&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 164627132 471065455 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51423680 OC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)c1cc2c(F)cccc2[nH]1 50575311 CHEMBL4875916 Interleukin-2 750 ChEMBL 10.1021/acs.jmedchem.1c01693 10.7270/Q2H135TK 34821503 Gironda-Martínez, A; Gorre, ÉMD; Prati, L; Gosalbes, JF; Dakhel, S; Cazzamalli, S; Samain, F; Donckele, EJ; Neri, D Philochem AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50575311 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50575311&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 164628506 471065456 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51423681 OC(=O)[C@H](Cc1ccc(I)cc1)NC(=O)c1cc2c(F)cccc2[nH]1 50575312 CHEMBL4852232 Interleukin-2 640 ChEMBL 10.1021/acs.jmedchem.1c01693 10.7270/Q2H135TK 34821503 Gironda-Martínez, A; Gorre, ÉMD; Prati, L; Gosalbes, JF; Dakhel, S; Cazzamalli, S; Samain, F; Donckele, EJ; Neri, D Philochem AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50575312 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50575312&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 164610657 471065457 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51423682 OC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1cc2c(F)cccc2[nH]1 50575313 CHEMBL4876740 Interleukin-2 1400 ChEMBL 10.1021/acs.jmedchem.1c01693 10.7270/Q2H135TK 34821503 Gironda-Martínez, A; Gorre, ÉMD; Prati, L; Gosalbes, JF; Dakhel, S; Cazzamalli, S; Samain, F; Donckele, EJ; Neri, D Philochem AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50575313 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50575313&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 164628698 471065458 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51423683 OC(=O)[C@H](Cc1cccc(I)c1)NC(=O)c1cc2c(F)cccc2[nH]1 50575314 CHEMBL4874500 Interleukin-2 250 ChEMBL 10.1021/acs.jmedchem.1c01693 10.7270/Q2H135TK 34821503 Gironda-Martínez, A; Gorre, ÉMD; Prati, L; Gosalbes, JF; Dakhel, S; Cazzamalli, S; Samain, F; Donckele, EJ; Neri, D Philochem AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50575314 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50575314&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 164628147 471065459 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51423684 OC(=O)[C@H](Cc1ccc(O)c(I)c1)NC(=O)c1c[nH]c2cccc(F)c12 50575315 CHEMBL4870525 Interleukin-2 510 ChEMBL 10.1021/acs.jmedchem.1c01693 10.7270/Q2H135TK 34821503 Gironda-Martínez, A; Gorre, ÉMD; Prati, L; Gosalbes, JF; Dakhel, S; Cazzamalli, S; Samain, F; Donckele, EJ; Neri, D Philochem AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50575315 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50575315&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 164621124 471065460 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51423685 OC(=O)[C@H](Cc1ccc(O)c(I)c1)NC(=O)c1cc2cc(F)ccc2[nH]1 50575316 CHEMBL4866759 Interleukin-2 330 ChEMBL 10.1021/acs.jmedchem.1c01693 10.7270/Q2H135TK 34821503 Gironda-Martínez, A; Gorre, ÉMD; Prati, L; Gosalbes, JF; Dakhel, S; Cazzamalli, S; Samain, F; Donckele, EJ; Neri, D Philochem AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50575316 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50575316&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 164620577 471065461 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51423686 OC(=O)[C@H](Cc1ccc(O)c(I)c1)NC(=O)c1cc2ccc(F)cc2[nH]1 50575317 CHEMBL4845813 Interleukin-2 280 ChEMBL 10.1021/acs.jmedchem.1c01693 10.7270/Q2H135TK 34821503 Gironda-Martínez, A; Gorre, ÉMD; Prati, L; Gosalbes, JF; Dakhel, S; Cazzamalli, S; Samain, F; Donckele, EJ; Neri, D Philochem AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50575317 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50575317&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 164609417 471065462 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51423687 OC(=O)[C@H](Cc1ccc(O)c(I)c1)NC(=O)c1cc2cccc(F)c2[nH]1 50575318 CHEMBL4870031 Interleukin-2 390 ChEMBL 10.1021/acs.jmedchem.1c01693 10.7270/Q2H135TK 34821503 Gironda-Martínez, A; Gorre, ÉMD; Prati, L; Gosalbes, JF; Dakhel, S; Cazzamalli, S; Samain, F; Donckele, EJ; Neri, D Philochem AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50575318 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50575318&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 164621948 471065463 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51423688 OC(=O)[C@H](Cc1ccc(O)c(I)c1)NC(=O)c1cc2ccccc2[nH]1 50575319 CHEMBL4869829 Interleukin-2 420 ChEMBL 10.1021/acs.jmedchem.1c01693 10.7270/Q2H135TK 34821503 Gironda-Martínez, A; Gorre, ÉMD; Prati, L; Gosalbes, JF; Dakhel, S; Cazzamalli, S; Samain, F; Donckele, EJ; Neri, D Philochem AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50575319 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50575319&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 164624661 471065464 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51423689 OC(=O)[C@H](Cc1ccc(O)c(I)c1)NC(=O)c1cc2c(F)cccc2o1 InChI=1S/C18H13FINO5/c19-11-2-1-3-15-10(11)8-16(26-15)17(23)21-13(18(24)25)7-9-4-5-14(22)12(20)6-9/h1-6,8,13,22H,7H2,(H,21,23)(H,24,25)/t13-/m0/s1 HSYJHVNQOBGYFY-ZDUSSCGKSA-N 50575320 CHEMBL4863588 Interleukin-2 2200 ChEMBL 10.1021/acs.jmedchem.1c01693 10.7270/Q2H135TK 34821503 Gironda-Martínez, A; Gorre, ÉMD; Prati, L; Gosalbes, JF; Dakhel, S; Cazzamalli, S; Samain, F; Donckele, EJ; Neri, D Philochem AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50575320 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50575320&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 164624485 471065465 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51423690 NC(=N)NCCC[C@H](NC(=O)[C@H](Cc1ccc(O)c(I)c1)NC(=O)c1cc2c(F)cccc2[nH]1)C(O)=O 50575321 CHEMBL4851618 Interleukin-2 340 ChEMBL 10.1021/acs.jmedchem.1c01693 10.7270/Q2H135TK 34821503 Gironda-Martínez, A; Gorre, ÉMD; Prati, L; Gosalbes, JF; Dakhel, S; Cazzamalli, S; Samain, F; Donckele, EJ; Neri, D Philochem AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50575321 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50575321&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 164616759 471065466 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51423691 NC(=N)NCCC[C@H](NC(=O)[C@@H](Cc1ccc(O)c(I)c1)NC(=O)c1cc2c(F)cccc2[nH]1)C(O)=O 50575322 CHEMBL4861027 Interleukin-2 1200 ChEMBL 10.1021/acs.jmedchem.1c01693 10.7270/Q2H135TK 34821503 Gironda-Martínez, A; Gorre, ÉMD; Prati, L; Gosalbes, JF; Dakhel, S; Cazzamalli, S; Samain, F; Donckele, EJ; Neri, D Philochem AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50575322 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50575322&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 164616566 471065467 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51423692 NC(=N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccc(O)c(I)c1)NC(=O)c1cc2c(F)cccc2[nH]1)C(O)=O 50575323 CHEMBL4871406 Interleukin-2 710 ChEMBL 10.1021/acs.jmedchem.1c01693 10.7270/Q2H135TK 34821503 Gironda-Martínez, A; Gorre, ÉMD; Prati, L; Gosalbes, JF; Dakhel, S; Cazzamalli, S; Samain, F; Donckele, EJ; Neri, D Philochem AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50575323 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50575323&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 164620327 471065468 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51423693 NC(=N)NCCC[C@@H](NC(=O)[C@H](Cc1ccc(O)c(I)c1)NC(=O)c1cc2c(F)cccc2[nH]1)C(O)=O 50575324 CHEMBL4846246 Interleukin-2 870 ChEMBL 10.1021/acs.jmedchem.1c01693 10.7270/Q2H135TK 34821503 Gironda-Martínez, A; Gorre, ÉMD; Prati, L; Gosalbes, JF; Dakhel, S; Cazzamalli, S; Samain, F; Donckele, EJ; Neri, D Philochem AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50575324 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50575324&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 164609120 471065469 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51423694 COC(=O)[C@H](Cc1ccc(cc1)C#Cc1ccccc1)NC(=O)C[C@@H]1CCCN(C1)C(N)=N InChI=1S/C26H30N4O3/c1-33-25(32)23(29-24(31)17-22-8-5-15-30(18-22)26(27)28)16-21-13-11-20(12-14-21)10-9-19-6-3-2-4-7-19/h2-4,6-7,11-14,22-23H,5,8,15-18H2,1H3,(H3,27,28)(H,29,31)/t22-,23-/m0/s1 MRNGXYMKYHNMLV-GOTSBHOMSA-N 50575325 CHEMBL4867370 Interleukin-2 1500 ChEMBL 10.1021/acs.jmedchem.1c01693 10.7270/Q2H135TK 34821503 Gironda-Martínez, A; Gorre, ÉMD; Prati, L; Gosalbes, JF; Dakhel, S; Cazzamalli, S; Samain, F; Donckele, EJ; Neri, D Philochem AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50575325 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50575325&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 92436659 471065470 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51423719 NC(=N)NCCC[C@H](NC(=O)[C@H](Cc1ccc(O)c(I)c1)NC(=O)c1cc2c(F)cccc2[nH]1)C(O)=O 50575321 CHEMBL4851618 Interleukin-2 3400 ChEMBL 10.1021/acs.jmedchem.1c01693 10.7270/Q2H135TK 34821503 Gironda-Martínez, A; Gorre, ÉMD; Prati, L; Gosalbes, JF; Dakhel, S; Cazzamalli, S; Samain, F; Donckele, EJ; Neri, D Philochem AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50575321 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50575321&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 164616759 471065466 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51423720 COC(=O)[C@H](Cc1ccc(cc1)C#Cc1ccccc1)NC(=O)C[C@@H]1CCCN(C1)C(N)=N InChI=1S/C26H30N4O3/c1-33-25(32)23(29-24(31)17-22-8-5-15-30(18-22)26(27)28)16-21-13-11-20(12-14-21)10-9-19-6-3-2-4-7-19/h2-4,6-7,11-14,22-23H,5,8,15-18H2,1H3,(H3,27,28)(H,29,31)/t22-,23-/m0/s1 MRNGXYMKYHNMLV-GOTSBHOMSA-N 50575325 CHEMBL4867370 Interleukin-2 22000 ChEMBL 10.1021/acs.jmedchem.1c01693 10.7270/Q2H135TK 34821503 Gironda-Martínez, A; Gorre, ÉMD; Prati, L; Gosalbes, JF; Dakhel, S; Cazzamalli, S; Samain, F; Donckele, EJ; Neri, D Philochem AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50575325 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50575325&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 92436659 471065470 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51423721 CC(C)CC([NH+]=C(N)N)C(=O)NCC(=O)N1CCC(CC1)c1cc(nn1C)-c1ccc(OCc2ccc(o2)C([O-])=O)c(Cl)c1Cl InChI=1S/C30H37Cl2N7O6/c1-16(2)12-21(36-30(33)34)28(41)35-14-25(40)39-10-8-17(9-11-39)22-13-20(37-38(22)3)19-5-7-23(27(32)26(19)31)44-15-18-4-6-24(45-18)29(42)43/h4-7,13,16-17,21H,8-12,14-15H2,1-3H3,(H,35,41)(H,42,43)(H4,33,34,36) VNZHOIDQBPFEJU-UHFFFAOYSA-N 50229786 5-[2,3-DICHLORO-4-(5-{1-[2-(2-GUANIDINO-4-METHYL-PENTANOYLAMINO)-ACETYL]-PIPERIDIN-4-YL}-1-METHYL-1H-PYRAZOL-3-YL)-PHENOXYMETHYL]-FURAN-2-CARBOXYLIC ACID::5-[2,3-Dichloro-4-(5-{1-[2-((R)-2-guanidino-4-methyl-1-oxo-pentylamino)-acetyl]-piperidin-4-yl}-1-methyl-1H-pyrazol-3-yl)-phenoxymethyl]-furan-2-carboxylic acid::5-[2,3-Dichloro-4-(5-{1-[2-((R)-2-guanidino-4-methyl-pentanoylamino)-acetyl]-piperidin-4-yl}-1-methyl-1H-pyrazol-3-yl)-phenoxymethyl]-furan-2-carboxylic acid::CHEMBL429852::SP-4206 Interleukin-2 100 ChEMBL 10.1021/acs.jmedchem.1c01693 10.7270/Q2H135TK 34821503 Gironda-Martínez, A; Gorre, ÉMD; Prati, L; Gosalbes, JF; Dakhel, S; Cazzamalli, S; Samain, F; Donckele, EJ; Neri, D Philochem AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50229786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50229786&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 91935514 104098213 47417 CHEMBL429852 ZINC03990365 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51423722 COc1ccc(cc1-c1cnc(NC(=O)c2c(F)cccc2F)cn1)C1=NOC(C)(C)C1=O InChI=1S/C23H18F2N4O4/c1-23(2)21(30)20(29-33-23)12-7-8-17(32-3)13(9-12)16-10-27-18(11-26-16)28-22(31)19-14(24)5-4-6-15(19)25/h4-11H,1-3H3,(H,27,28,31) XTRBTNQVRQZIGY-UHFFFAOYSA-N 50575326 CHEMBL4868517 Interleukin-2 50 ChEMBL 10.1021/acs.jmedchem.1c01403 10.7270/Q2C82F4Q 34843241 Khedkar, NR; Irlapatti, NR; Dadke, D; Kanoje, V; Shaikh, Z; Karche, V; Shinde, V; Deshmukh, G; Patil, A; Jachak, S; Phukan, S; Kizhakinagath, PA; Gholve, M; Bhankhede, T; Daler, J; Nemade, HN; Budhe, S; Pareek, H; Yeshodharan, R; Gupta, R; Kalia, A; Pandey, D; Wagh, A; Kumar, S; Patil, V; Modi, D; Sharma, N; Ahirrao, P; Mehta, M; Kumar, H; Nigade, P; Tamane, K; Mallurwar, S; Kuldharan, S; Pawar, S; Vishwase, G; Bokan, S; Singh, M; Naik, K; Ingawale, S; Shankar, R; Kamalakannan, P; Venugopal, S; George, SK; Padiya, KJ; Nemmani, KVS; Gundu, J; Bhonde, M; Narasimham, L; Sindkhedkar, M; Shah, C; Sinha, N; Sharma, S; Bakhle, D; Kamboj, RK; Palle, VP Lupin Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50575326 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50575326&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 57330381 471065471 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51423723 Cc1ccc(cc1-c1cnc(NC(=O)c2c(F)cccc2F)cn1)C1=NOC(C)(C)C1=O InChI=1S/C23H18F2N4O3/c1-12-7-8-13(20-21(30)23(2,3)32-29-20)9-14(12)17-10-27-18(11-26-17)28-22(31)19-15(24)5-4-6-16(19)25/h4-11H,1-3H3,(H,27,28,31) KIRGYLPPCCUTOD-UHFFFAOYSA-N 50575327 CHEMBL4848840 Interleukin-2 34 ChEMBL 10.1021/acs.jmedchem.1c01403 10.7270/Q2C82F4Q 34843241 Khedkar, NR; Irlapatti, NR; Dadke, D; Kanoje, V; Shaikh, Z; Karche, V; Shinde, V; Deshmukh, G; Patil, A; Jachak, S; Phukan, S; Kizhakinagath, PA; Gholve, M; Bhankhede, T; Daler, J; Nemade, HN; Budhe, S; Pareek, H; Yeshodharan, R; Gupta, R; Kalia, A; Pandey, D; Wagh, A; Kumar, S; Patil, V; Modi, D; Sharma, N; Ahirrao, P; Mehta, M; Kumar, H; Nigade, P; Tamane, K; Mallurwar, S; Kuldharan, S; Pawar, S; Vishwase, G; Bokan, S; Singh, M; Naik, K; Ingawale, S; Shankar, R; Kamalakannan, P; Venugopal, S; George, SK; Padiya, KJ; Nemmani, KVS; Gundu, J; Bhonde, M; Narasimham, L; Sindkhedkar, M; Shah, C; Sinha, N; Sharma, S; Bakhle, D; Kamboj, RK; Palle, VP Lupin Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50575327 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50575327&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 57330317 471065472 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51423724 CCc1ccc(cc1-c1cnc(NC(=O)c2c(F)cccc2F)cn1)C1=NOC(C)(C)C1=O InChI=1S/C24H20F2N4O3/c1-4-13-8-9-14(21-22(31)24(2,3)33-30-21)10-15(13)18-11-28-19(12-27-18)29-23(32)20-16(25)6-5-7-17(20)26/h5-12H,4H2,1-3H3,(H,28,29,32) CLARLFPKHDVVPQ-UHFFFAOYSA-N 50575328 CHEMBL4868367 Interleukin-2 32 ChEMBL 10.1021/acs.jmedchem.1c01403 10.7270/Q2C82F4Q 34843241 Khedkar, NR; Irlapatti, NR; Dadke, D; Kanoje, V; Shaikh, Z; Karche, V; Shinde, V; Deshmukh, G; Patil, A; Jachak, S; Phukan, S; Kizhakinagath, PA; Gholve, M; Bhankhede, T; Daler, J; Nemade, HN; Budhe, S; Pareek, H; Yeshodharan, R; Gupta, R; Kalia, A; Pandey, D; Wagh, A; Kumar, S; Patil, V; Modi, D; Sharma, N; Ahirrao, P; Mehta, M; Kumar, H; Nigade, P; Tamane, K; Mallurwar, S; Kuldharan, S; Pawar, S; Vishwase, G; Bokan, S; Singh, M; Naik, K; Ingawale, S; Shankar, R; Kamalakannan, P; Venugopal, S; George, SK; Padiya, KJ; Nemmani, KVS; Gundu, J; Bhonde, M; Narasimham, L; Sindkhedkar, M; Shah, C; Sinha, N; Sharma, S; Bakhle, D; Kamboj, RK; Palle, VP Lupin Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50575328 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50575328&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 57330320 471065473 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51423725 Cc1ccc(cc1-c1cnc(NC(=O)c2c(F)cccc2F)cn1)C1=NOC(C)(C)C1 InChI=1S/C23H20F2N4O2/c1-13-7-8-14(18-10-23(2,3)31-29-18)9-15(13)19-11-27-20(12-26-19)28-22(30)21-16(24)5-4-6-17(21)25/h4-9,11-12H,10H2,1-3H3,(H,27,28,30) DREFJQDUVPJVKI-UHFFFAOYSA-N 387290 N-(5- (5,5-Dimethyl-4,5- dihydroisoxazol-3- yl)-2- methylphenyl)pyrazin- 2-yl)-2,6- difluorobenzamide::US10292981, Example 53 Interleukin-2 328 ChEMBL 10.1021/acs.jmedchem.1c01403 10.7270/Q2C82F4Q 34843241 Khedkar, NR; Irlapatti, NR; Dadke, D; Kanoje, V; Shaikh, Z; Karche, V; Shinde, V; Deshmukh, G; Patil, A; Jachak, S; Phukan, S; Kizhakinagath, PA; Gholve, M; Bhankhede, T; Daler, J; Nemade, HN; Budhe, S; Pareek, H; Yeshodharan, R; Gupta, R; Kalia, A; Pandey, D; Wagh, A; Kumar, S; Patil, V; Modi, D; Sharma, N; Ahirrao, P; Mehta, M; Kumar, H; Nigade, P; Tamane, K; Mallurwar, S; Kuldharan, S; Pawar, S; Vishwase, G; Bokan, S; Singh, M; Naik, K; Ingawale, S; Shankar, R; Kamalakannan, P; Venugopal, S; George, SK; Padiya, KJ; Nemmani, KVS; Gundu, J; Bhonde, M; Narasimham, L; Sindkhedkar, M; Shah, C; Sinha, N; Sharma, S; Bakhle, D; Kamboj, RK; Palle, VP Lupin Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387290 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387290&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89771956 404856405 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51423726 Cc1ccc(cc1-c1cnc(NC(=O)c2c(F)cccc2F)cn1)-c1nn(C)c(=O)o1 InChI=1S/C21H15F2N5O3/c1-11-6-7-12(20-27-28(2)21(30)31-20)8-13(11)16-9-25-17(10-24-16)26-19(29)18-14(22)4-3-5-15(18)23/h3-10H,1-2H3,(H,25,26,29) NQLUEONWNDPITM-UHFFFAOYSA-N 387270 2,6- Difluoro-N-(5-(2- methyl-5-(4- methyl-5-oxo-4,5- dihydro-1,3,4- oxadiazol-2- yl)phenyl)pyrazin- 2-yl)benzamide::US10292981, Example 87 Interleukin-2 64 ChEMBL 10.1021/acs.jmedchem.1c01403 10.7270/Q2C82F4Q 34843241 Khedkar, NR; Irlapatti, NR; Dadke, D; Kanoje, V; Shaikh, Z; Karche, V; Shinde, V; Deshmukh, G; Patil, A; Jachak, S; Phukan, S; Kizhakinagath, PA; Gholve, M; Bhankhede, T; Daler, J; Nemade, HN; Budhe, S; Pareek, H; Yeshodharan, R; Gupta, R; Kalia, A; Pandey, D; Wagh, A; Kumar, S; Patil, V; Modi, D; Sharma, N; Ahirrao, P; Mehta, M; Kumar, H; Nigade, P; Tamane, K; Mallurwar, S; Kuldharan, S; Pawar, S; Vishwase, G; Bokan, S; Singh, M; Naik, K; Ingawale, S; Shankar, R; Kamalakannan, P; Venugopal, S; George, SK; Padiya, KJ; Nemmani, KVS; Gundu, J; Bhonde, M; Narasimham, L; Sindkhedkar, M; Shah, C; Sinha, N; Sharma, S; Bakhle, D; Kamboj, RK; Palle, VP Lupin Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387270 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387270&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89763991 404856385 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51423727 Cc1c(cccc1-c1cnc(NC(=O)c2c(F)cccc2F)cn1)C1=NOC(C)(C)C1=O InChI=1S/C23H18F2N4O3/c1-12-13(6-4-7-14(12)20-21(30)23(2,3)32-29-20)17-10-27-18(11-26-17)28-22(31)19-15(24)8-5-9-16(19)25/h4-11H,1-3H3,(H,27,28,31) AQPYVJQWAVKAEM-UHFFFAOYSA-N 50575329 CHEMBL4859192 Interleukin-2 55 ChEMBL 10.1021/acs.jmedchem.1c01403 10.7270/Q2C82F4Q 34843241 Khedkar, NR; Irlapatti, NR; Dadke, D; Kanoje, V; Shaikh, Z; Karche, V; Shinde, V; Deshmukh, G; Patil, A; Jachak, S; Phukan, S; Kizhakinagath, PA; Gholve, M; Bhankhede, T; Daler, J; Nemade, HN; Budhe, S; Pareek, H; Yeshodharan, R; Gupta, R; Kalia, A; Pandey, D; Wagh, A; Kumar, S; Patil, V; Modi, D; Sharma, N; Ahirrao, P; Mehta, M; Kumar, H; Nigade, P; Tamane, K; Mallurwar, S; Kuldharan, S; Pawar, S; Vishwase, G; Bokan, S; Singh, M; Naik, K; Ingawale, S; Shankar, R; Kamalakannan, P; Venugopal, S; George, SK; Padiya, KJ; Nemmani, KVS; Gundu, J; Bhonde, M; Narasimham, L; Sindkhedkar, M; Shah, C; Sinha, N; Sharma, S; Bakhle, D; Kamboj, RK; Palle, VP Lupin Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50575329 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50575329&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89764054 471065474 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51423728 Cc1ccc(cc1-c1cnc(cn1)C(=O)Nc1c(F)cccc1F)C1=NOC(C)(C)C1=O InChI=1S/C23H18F2N4O3/c1-12-7-8-13(19-21(30)23(2,3)32-29-19)9-14(12)17-10-27-18(11-26-17)22(31)28-20-15(24)5-4-6-16(20)25/h4-11H,1-3H3,(H,28,31) KDVVIMMGQHFHBT-UHFFFAOYSA-N 387297 US10292981, Example 121 Interleukin-2 150 ChEMBL 10.1021/acs.jmedchem.1c01403 10.7270/Q2C82F4Q 34843241 Khedkar, NR; Irlapatti, NR; Dadke, D; Kanoje, V; Shaikh, Z; Karche, V; Shinde, V; Deshmukh, G; Patil, A; Jachak, S; Phukan, S; Kizhakinagath, PA; Gholve, M; Bhankhede, T; Daler, J; Nemade, HN; Budhe, S; Pareek, H; Yeshodharan, R; Gupta, R; Kalia, A; Pandey, D; Wagh, A; Kumar, S; Patil, V; Modi, D; Sharma, N; Ahirrao, P; Mehta, M; Kumar, H; Nigade, P; Tamane, K; Mallurwar, S; Kuldharan, S; Pawar, S; Vishwase, G; Bokan, S; Singh, M; Naik, K; Ingawale, S; Shankar, R; Kamalakannan, P; Venugopal, S; George, SK; Padiya, KJ; Nemmani, KVS; Gundu, J; Bhonde, M; Narasimham, L; Sindkhedkar, M; Shah, C; Sinha, N; Sharma, S; Bakhle, D; Kamboj, RK; Palle, VP Lupin Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387297&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 57330782 404856412 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51423729 Cc1ccc(cc1-c1cnc(NC(=O)c2ccccc2Cl)cn1)C1=NOC(C)(C)C1=O InChI=1S/C23H19ClN4O3/c1-13-8-9-14(20-21(29)23(2,3)31-28-20)10-16(13)18-11-26-19(12-25-18)27-22(30)15-6-4-5-7-17(15)24/h4-12H,1-3H3,(H,26,27,30) GDPDBPBRFMYPNO-UHFFFAOYSA-N 387294 US10292981, Example 78 Interleukin-2 171 ChEMBL 10.1021/acs.jmedchem.1c01403 10.7270/Q2C82F4Q 34843241 Khedkar, NR; Irlapatti, NR; Dadke, D; Kanoje, V; Shaikh, Z; Karche, V; Shinde, V; Deshmukh, G; Patil, A; Jachak, S; Phukan, S; Kizhakinagath, PA; Gholve, M; Bhankhede, T; Daler, J; Nemade, HN; Budhe, S; Pareek, H; Yeshodharan, R; Gupta, R; Kalia, A; Pandey, D; Wagh, A; Kumar, S; Patil, V; Modi, D; Sharma, N; Ahirrao, P; Mehta, M; Kumar, H; Nigade, P; Tamane, K; Mallurwar, S; Kuldharan, S; Pawar, S; Vishwase, G; Bokan, S; Singh, M; Naik, K; Ingawale, S; Shankar, R; Kamalakannan, P; Venugopal, S; George, SK; Padiya, KJ; Nemmani, KVS; Gundu, J; Bhonde, M; Narasimham, L; Sindkhedkar, M; Shah, C; Sinha, N; Sharma, S; Bakhle, D; Kamboj, RK; Palle, VP Lupin Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387294&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 57330623 404856409 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51423730 Cc1ccc(cc1-c1cnc(NC(=O)c2c(F)cccc2Cl)cn1)C1=NOC(C)(C)C1=O InChI=1S/C23H18ClFN4O3/c1-12-7-8-13(20-21(30)23(2,3)32-29-20)9-14(12)17-10-27-18(11-26-17)28-22(31)19-15(24)5-4-6-16(19)25/h4-11H,1-3H3,(H,27,28,31) KFLVVCARMXCDDZ-UHFFFAOYSA-N 387269 2- Chloro-N-(5-(5-(5,5- dimethyl-4-oxo-4,5- dihydroisoxazol-3- yl)-2-methyl phenyl)pyrazin-2-yl)- 6-fluorobenzamide::US10292981, Example 80 Interleukin-2 65 ChEMBL 10.1021/acs.jmedchem.1c01403 10.7270/Q2C82F4Q 34843241 Khedkar, NR; Irlapatti, NR; Dadke, D; Kanoje, V; Shaikh, Z; Karche, V; Shinde, V; Deshmukh, G; Patil, A; Jachak, S; Phukan, S; Kizhakinagath, PA; Gholve, M; Bhankhede, T; Daler, J; Nemade, HN; Budhe, S; Pareek, H; Yeshodharan, R; Gupta, R; Kalia, A; Pandey, D; Wagh, A; Kumar, S; Patil, V; Modi, D; Sharma, N; Ahirrao, P; Mehta, M; Kumar, H; Nigade, P; Tamane, K; Mallurwar, S; Kuldharan, S; Pawar, S; Vishwase, G; Bokan, S; Singh, M; Naik, K; Ingawale, S; Shankar, R; Kamalakannan, P; Venugopal, S; George, SK; Padiya, KJ; Nemmani, KVS; Gundu, J; Bhonde, M; Narasimham, L; Sindkhedkar, M; Shah, C; Sinha, N; Sharma, S; Bakhle, D; Kamboj, RK; Palle, VP Lupin Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387269 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387269&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 67515178 404856384 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51423731 Cc1ccc(cc1-c1cnc(NC(=O)c2c(F)cncc2F)cn1)C1=NOC(C)(C)C1=O InChI=1S/C22H17F2N5O3/c1-11-4-5-12(19-20(30)22(2,3)32-29-19)6-13(11)16-9-27-17(10-26-16)28-21(31)18-14(23)7-25-8-15(18)24/h4-10H,1-3H3,(H,27,28,31) VWWZLAHHWMLIIM-UHFFFAOYSA-N 387272 N-(5-(5- (5,5-dimethyl-4-oxo- 4,5-dihydroisoxazol-3- yl)-2- methylphenyl)pyrazin- 2-yl)-3,5- difluoroisonicotinamide::US10292981, Example 114 Interleukin-2 94 ChEMBL 10.1021/acs.jmedchem.1c01403 10.7270/Q2C82F4Q 34843241 Khedkar, NR; Irlapatti, NR; Dadke, D; Kanoje, V; Shaikh, Z; Karche, V; Shinde, V; Deshmukh, G; Patil, A; Jachak, S; Phukan, S; Kizhakinagath, PA; Gholve, M; Bhankhede, T; Daler, J; Nemade, HN; Budhe, S; Pareek, H; Yeshodharan, R; Gupta, R; Kalia, A; Pandey, D; Wagh, A; Kumar, S; Patil, V; Modi, D; Sharma, N; Ahirrao, P; Mehta, M; Kumar, H; Nigade, P; Tamane, K; Mallurwar, S; Kuldharan, S; Pawar, S; Vishwase, G; Bokan, S; Singh, M; Naik, K; Ingawale, S; Shankar, R; Kamalakannan, P; Venugopal, S; George, SK; Padiya, KJ; Nemmani, KVS; Gundu, J; Bhonde, M; Narasimham, L; Sindkhedkar, M; Shah, C; Sinha, N; Sharma, S; Bakhle, D; Kamboj, RK; Palle, VP Lupin Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387272 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387272&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 67515995 404856387 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51423732 Cc1ccc(cc1-c1ccc(NC(=O)c2c(F)cccc2F)nc1)C1=NOC(C)(C)C1=O InChI=1S/C24H19F2N3O3/c1-13-7-8-14(21-22(30)24(2,3)32-29-21)11-16(13)15-9-10-19(27-12-15)28-23(31)20-17(25)5-4-6-18(20)26/h4-12H,1-3H3,(H,27,28,31) BBFUAFQFQUCONY-UHFFFAOYSA-N 387281 N-(5-(5- (5,5-Dimethyl-4-oxo- 4,5-dihydroisoxazol- 3-yl)-2- methylphenyl)pyridin- 2-yl)-2,6- difluorobenzamide ::US10292981, Example 4 Interleukin-2 178 ChEMBL 10.1021/acs.jmedchem.1c01403 10.7270/Q2C82F4Q 34843241 Khedkar, NR; Irlapatti, NR; Dadke, D; Kanoje, V; Shaikh, Z; Karche, V; Shinde, V; Deshmukh, G; Patil, A; Jachak, S; Phukan, S; Kizhakinagath, PA; Gholve, M; Bhankhede, T; Daler, J; Nemade, HN; Budhe, S; Pareek, H; Yeshodharan, R; Gupta, R; Kalia, A; Pandey, D; Wagh, A; Kumar, S; Patil, V; Modi, D; Sharma, N; Ahirrao, P; Mehta, M; Kumar, H; Nigade, P; Tamane, K; Mallurwar, S; Kuldharan, S; Pawar, S; Vishwase, G; Bokan, S; Singh, M; Naik, K; Ingawale, S; Shankar, R; Kamalakannan, P; Venugopal, S; George, SK; Padiya, KJ; Nemmani, KVS; Gundu, J; Bhonde, M; Narasimham, L; Sindkhedkar, M; Shah, C; Sinha, N; Sharma, S; Bakhle, D; Kamboj, RK; Palle, VP Lupin Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387281&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 57330319 404856396 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51423733 Cc1ccc(cc1-c1ccc(NC(=O)c2c(F)cccc2F)cc1)C1=NOC(C)(C)C1=O InChI=1S/C25H20F2N2O3/c1-14-7-8-16(22-23(30)25(2,3)32-29-22)13-18(14)15-9-11-17(12-10-15)28-24(31)21-19(26)5-4-6-20(21)27/h4-13H,1-3H3,(H,28,31) QCIJFVBUOPDNBC-UHFFFAOYSA-N 387261 N-(5′- (5,5-Dimethyl-4-oxo- 4,5-dihydroisoxazol- 3-yl)-2′-methyl-[1,1′- biphenyl]-4-yl-2,6- difluorobenzamide::US10292981, Example 3 Interleukin-2 69 ChEMBL 10.1021/acs.jmedchem.1c01403 10.7270/Q2C82F4Q 34843241 Khedkar, NR; Irlapatti, NR; Dadke, D; Kanoje, V; Shaikh, Z; Karche, V; Shinde, V; Deshmukh, G; Patil, A; Jachak, S; Phukan, S; Kizhakinagath, PA; Gholve, M; Bhankhede, T; Daler, J; Nemade, HN; Budhe, S; Pareek, H; Yeshodharan, R; Gupta, R; Kalia, A; Pandey, D; Wagh, A; Kumar, S; Patil, V; Modi, D; Sharma, N; Ahirrao, P; Mehta, M; Kumar, H; Nigade, P; Tamane, K; Mallurwar, S; Kuldharan, S; Pawar, S; Vishwase, G; Bokan, S; Singh, M; Naik, K; Ingawale, S; Shankar, R; Kamalakannan, P; Venugopal, S; George, SK; Padiya, KJ; Nemmani, KVS; Gundu, J; Bhonde, M; Narasimham, L; Sindkhedkar, M; Shah, C; Sinha, N; Sharma, S; Bakhle, D; Kamboj, RK; Palle, VP Lupin Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387261 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387261&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 56958618 404856376 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51423734 Cc1ccc(cc1-c1ccc(NC(=O)c2c(F)cccc2F)cc1)-c1nn(C)c(=O)o1 InChI=1S/C23H17F2N3O3/c1-13-6-7-15(22-27-28(2)23(30)31-22)12-17(13)14-8-10-16(11-9-14)26-21(29)20-18(24)4-3-5-19(20)25/h3-12H,1-2H3,(H,26,29) NKLWMFLCTSEIFM-UHFFFAOYSA-N 387265 2,6- Difluoro-N-(2′- methyl-5′-(4-methyl- 5-oxo-4,5-dihydro- 1,3,4-oxadiazol-2-yl)- [1,1′-biphenyl]-4- yl)benzamide::US10292981, Example 33 Interleukin-2 34 ChEMBL 10.1021/acs.jmedchem.1c01403 10.7270/Q2C82F4Q 34843241 Khedkar, NR; Irlapatti, NR; Dadke, D; Kanoje, V; Shaikh, Z; Karche, V; Shinde, V; Deshmukh, G; Patil, A; Jachak, S; Phukan, S; Kizhakinagath, PA; Gholve, M; Bhankhede, T; Daler, J; Nemade, HN; Budhe, S; Pareek, H; Yeshodharan, R; Gupta, R; Kalia, A; Pandey, D; Wagh, A; Kumar, S; Patil, V; Modi, D; Sharma, N; Ahirrao, P; Mehta, M; Kumar, H; Nigade, P; Tamane, K; Mallurwar, S; Kuldharan, S; Pawar, S; Vishwase, G; Bokan, S; Singh, M; Naik, K; Ingawale, S; Shankar, R; Kamalakannan, P; Venugopal, S; George, SK; Padiya, KJ; Nemmani, KVS; Gundu, J; Bhonde, M; Narasimham, L; Sindkhedkar, M; Shah, C; Sinha, N; Sharma, S; Bakhle, D; Kamboj, RK; Palle, VP Lupin Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387265 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387265&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 89763695 404856380 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51423735 CCn1nc(oc1=O)-c1ccc(C)c(c1)-c1ccc(NC(=O)c2c(F)cccc2F)cc1 InChI=1S/C24H19F2N3O3/c1-3-29-24(31)32-23(28-29)16-8-7-14(2)18(13-16)15-9-11-17(12-10-15)27-22(30)21-19(25)5-4-6-20(21)26/h4-13H,3H2,1-2H3,(H,27,30) OWPMRXOYWPQBNY-UHFFFAOYSA-N 387266 N-(5′- (4-Ethyl-5-oxo-4,5- dihydro-1,3,4- oxadiazol-2-yl)-2′- methyl-[1,1′- biphenyl]-4-yl)-2,6- difluorobenzamide::US10292981, Example 34 Interleukin-2 78 ChEMBL 10.1021/acs.jmedchem.1c01403 10.7270/Q2C82F4Q 34843241 Khedkar, NR; Irlapatti, NR; Dadke, D; Kanoje, V; Shaikh, Z; Karche, V; Shinde, V; Deshmukh, G; Patil, A; Jachak, S; Phukan, S; Kizhakinagath, PA; Gholve, M; Bhankhede, T; Daler, J; Nemade, HN; Budhe, S; Pareek, H; Yeshodharan, R; Gupta, R; Kalia, A; Pandey, D; Wagh, A; Kumar, S; Patil, V; Modi, D; Sharma, N; Ahirrao, P; Mehta, M; Kumar, H; Nigade, P; Tamane, K; Mallurwar, S; Kuldharan, S; Pawar, S; Vishwase, G; Bokan, S; Singh, M; Naik, K; Ingawale, S; Shankar, R; Kamalakannan, P; Venugopal, S; George, SK; Padiya, KJ; Nemmani, KVS; Gundu, J; Bhonde, M; Narasimham, L; Sindkhedkar, M; Shah, C; Sinha, N; Sharma, S; Bakhle, D; Kamboj, RK; Palle, VP Lupin Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387266&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 67517275 404856381 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51423736 Cc1ccc(cc1-c1ccc(NC(=O)c2c(F)cccc2F)cc1)-c1n[nH]c(=O)o1 InChI=1S/C22H15F2N3O3/c1-12-5-6-14(21-26-27-22(29)30-21)11-16(12)13-7-9-15(10-8-13)25-20(28)19-17(23)3-2-4-18(19)24/h2-11H,1H3,(H,25,28)(H,27,29) ILBQSVJVKJBSFF-UHFFFAOYSA-N 50575330 CHEMBL4872805 Interleukin-2 227 ChEMBL 10.1021/acs.jmedchem.1c01403 10.7270/Q2C82F4Q 34843241 Khedkar, NR; Irlapatti, NR; Dadke, D; Kanoje, V; Shaikh, Z; Karche, V; Shinde, V; Deshmukh, G; Patil, A; Jachak, S; Phukan, S; Kizhakinagath, PA; Gholve, M; Bhankhede, T; Daler, J; Nemade, HN; Budhe, S; Pareek, H; Yeshodharan, R; Gupta, R; Kalia, A; Pandey, D; Wagh, A; Kumar, S; Patil, V; Modi, D; Sharma, N; Ahirrao, P; Mehta, M; Kumar, H; Nigade, P; Tamane, K; Mallurwar, S; Kuldharan, S; Pawar, S; Vishwase, G; Bokan, S; Singh, M; Naik, K; Ingawale, S; Shankar, R; Kamalakannan, P; Venugopal, S; George, SK; Padiya, KJ; Nemmani, KVS; Gundu, J; Bhonde, M; Narasimham, L; Sindkhedkar, M; Shah, C; Sinha, N; Sharma, S; Bakhle, D; Kamboj, RK; Palle, VP Lupin Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50575330 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50575330&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 164621612 471065475 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51423737 Cc1c(cccc1-c1ccc(NC(=O)c2c(F)cccc2F)cc1)-c1nn(C)c(=O)o1 InChI=1S/C23H17F2N3O3/c1-13-16(5-3-6-17(13)22-27-28(2)23(30)31-22)14-9-11-15(12-10-14)26-21(29)20-18(24)7-4-8-19(20)25/h3-12H,1-2H3,(H,26,29) ZKAHFFVNALZECX-UHFFFAOYSA-N 50575331 CHEMBL4868242 Interleukin-2 11 ChEMBL 10.1021/acs.jmedchem.1c01403 10.7270/Q2C82F4Q 34843241 Khedkar, NR; Irlapatti, NR; Dadke, D; Kanoje, V; Shaikh, Z; Karche, V; Shinde, V; Deshmukh, G; Patil, A; Jachak, S; Phukan, S; Kizhakinagath, PA; Gholve, M; Bhankhede, T; Daler, J; Nemade, HN; Budhe, S; Pareek, H; Yeshodharan, R; Gupta, R; Kalia, A; Pandey, D; Wagh, A; Kumar, S; Patil, V; Modi, D; Sharma, N; Ahirrao, P; Mehta, M; Kumar, H; Nigade, P; Tamane, K; Mallurwar, S; Kuldharan, S; Pawar, S; Vishwase, G; Bokan, S; Singh, M; Naik, K; Ingawale, S; Shankar, R; Kamalakannan, P; Venugopal, S; George, SK; Padiya, KJ; Nemmani, KVS; Gundu, J; Bhonde, M; Narasimham, L; Sindkhedkar, M; Shah, C; Sinha, N; Sharma, S; Bakhle, D; Kamboj, RK; Palle, VP Lupin Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50575331 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50575331&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 57330559 471065476 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51423738 Cc1c(cccc1-c1ccc(NC(=O)c2c(F)cccc2Cl)cc1)-c1nn(C)c(=O)o1 InChI=1S/C23H17ClFN3O3/c1-13-16(5-3-6-17(13)22-27-28(2)23(30)31-22)14-9-11-15(12-10-14)26-21(29)20-18(24)7-4-8-19(20)25/h3-12H,1-2H3,(H,26,29) QWKUOKJLHOMZRY-UHFFFAOYSA-N 50575332 CHEMBL4869725 Interleukin-2 14 ChEMBL 10.1021/acs.jmedchem.1c01403 10.7270/Q2C82F4Q 34843241 Khedkar, NR; Irlapatti, NR; Dadke, D; Kanoje, V; Shaikh, Z; Karche, V; Shinde, V; Deshmukh, G; Patil, A; Jachak, S; Phukan, S; Kizhakinagath, PA; Gholve, M; Bhankhede, T; Daler, J; Nemade, HN; Budhe, S; Pareek, H; Yeshodharan, R; Gupta, R; Kalia, A; Pandey, D; Wagh, A; Kumar, S; Patil, V; Modi, D; Sharma, N; Ahirrao, P; Mehta, M; Kumar, H; Nigade, P; Tamane, K; Mallurwar, S; Kuldharan, S; Pawar, S; Vishwase, G; Bokan, S; Singh, M; Naik, K; Ingawale, S; Shankar, R; Kamalakannan, P; Venugopal, S; George, SK; Padiya, KJ; Nemmani, KVS; Gundu, J; Bhonde, M; Narasimham, L; Sindkhedkar, M; Shah, C; Sinha, N; Sharma, S; Bakhle, D; Kamboj, RK; Palle, VP Lupin Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50575332 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50575332&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 67517826 471065477 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51423739 Fc1cccc(F)c1C(=O)Nc1ccc(cc1)-c1cc(ccc1Cl)C(F)(F)F InChI=1S/C20H11ClF5NO/c21-15-9-6-12(20(24,25)26)10-14(15)11-4-7-13(8-5-11)27-19(28)18-16(22)2-1-3-17(18)23/h1-10H,(H,27,28) OHHIGBIGGBDEJY-UHFFFAOYSA-N 50575333 CHEMBL4857063 Interleukin-2 8.0 ChEMBL 10.1021/acs.jmedchem.1c01403 10.7270/Q2C82F4Q 34843241 Khedkar, NR; Irlapatti, NR; Dadke, D; Kanoje, V; Shaikh, Z; Karche, V; Shinde, V; Deshmukh, G; Patil, A; Jachak, S; Phukan, S; Kizhakinagath, PA; Gholve, M; Bhankhede, T; Daler, J; Nemade, HN; Budhe, S; Pareek, H; Yeshodharan, R; Gupta, R; Kalia, A; Pandey, D; Wagh, A; Kumar, S; Patil, V; Modi, D; Sharma, N; Ahirrao, P; Mehta, M; Kumar, H; Nigade, P; Tamane, K; Mallurwar, S; Kuldharan, S; Pawar, S; Vishwase, G; Bokan, S; Singh, M; Naik, K; Ingawale, S; Shankar, R; Kamalakannan, P; Venugopal, S; George, SK; Padiya, KJ; Nemmani, KVS; Gundu, J; Bhonde, M; Narasimham, L; Sindkhedkar, M; Shah, C; Sinha, N; Sharma, S; Bakhle, D; Kamboj, RK; Palle, VP Lupin Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50575333 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50575333&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 11418465 471065478 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51423743 Cc1c(cccc1-c1ccc(NC(=O)c2c(F)cccc2F)cc1)-c1nn(C)c(=O)o1 InChI=1S/C23H17F2N3O3/c1-13-16(5-3-6-17(13)22-27-28(2)23(30)31-22)14-9-11-15(12-10-14)26-21(29)20-18(24)7-4-8-19(20)25/h3-12H,1-2H3,(H,26,29) ZKAHFFVNALZECX-UHFFFAOYSA-N 50575331 CHEMBL4868242 Interleukin-2 183 ChEMBL 10.1021/acs.jmedchem.1c01403 10.7270/Q2C82F4Q 34843241 Khedkar, NR; Irlapatti, NR; Dadke, D; Kanoje, V; Shaikh, Z; Karche, V; Shinde, V; Deshmukh, G; Patil, A; Jachak, S; Phukan, S; Kizhakinagath, PA; Gholve, M; Bhankhede, T; Daler, J; Nemade, HN; Budhe, S; Pareek, H; Yeshodharan, R; Gupta, R; Kalia, A; Pandey, D; Wagh, A; Kumar, S; Patil, V; Modi, D; Sharma, N; Ahirrao, P; Mehta, M; Kumar, H; Nigade, P; Tamane, K; Mallurwar, S; Kuldharan, S; Pawar, S; Vishwase, G; Bokan, S; Singh, M; Naik, K; Ingawale, S; Shankar, R; Kamalakannan, P; Venugopal, S; George, SK; Padiya, KJ; Nemmani, KVS; Gundu, J; Bhonde, M; Narasimham, L; Sindkhedkar, M; Shah, C; Sinha, N; Sharma, S; Bakhle, D; Kamboj, RK; Palle, VP Lupin Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50575331 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50575331&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 57330559 471065476 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51455282 C[C@H](N1CCOCC1)C(=O)N(C)c1cc2nc([nH]c2cc1C)-c1n[nH]c2C[C@@]3(C)C[C@H]3Cc12 InChI=1S/C25H30N6O2/c1-14-9-18-19(11-21(14)30(4)24(32)15(2)31-5-7-33-8-6-31)27-23(26-18)22-17-10-16-12-25(16,3)13-20(17)28-29-22/h9,11,15-16H,5-8,10,12-13H2,1-4H3/b23-22-/t15-,16+,25+/m0/s1 QRBOMAZQOWWGLE-BQPLSRGVSA-N 50587590 CHEMBL5084598::US11661419, Example 1 Interleukin-2 39 ChEMBL 10.1021/acsmedchemlett.1c00619 10.7270/Q2736VT6 34917248 Abdel-Magid, AF Therachem Research Medilab, LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50587590 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50587590&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 156494892 476023677 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51455283 C[C@@H](N1CCOCC1)C(=O)N(C)c1cc2nc([nH]c2cc1C)-c1n[nH]c2C[C@@]3(C)C[C@H]3Cc12 InChI=1S/C25H30N6O2/c1-14-9-18-19(11-21(14)30(4)24(32)15(2)31-5-7-33-8-6-31)27-23(26-18)22-17-10-16-12-25(16,3)13-20(17)28-29-22/h9,11,15-16H,5-8,10,12-13H2,1-4H3/b23-22-/t15-,16-,25-/m1/s1 QRBOMAZQOWWGLE-QWNONSSPSA-N 50587591 CHEMBL5080834::US11661419, Example 3 Interleukin-2 113 ChEMBL 10.1021/acsmedchemlett.1c00619 10.7270/Q2736VT6 34917248 Abdel-Magid, AF Therachem Research Medilab, LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50587591 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50587591&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 156494946 476023678 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51455284 C[C@H](C1CCOCC1)C(=O)N(C)c1ccc2[nH]c(nc2c1)-c1n[nH]c2C[C@@]3(C)C[C@H]3Cc12 InChI=1S/C25H29N5O2/c1-14(15-6-8-32-9-7-15)24(31)30(3)17-4-5-19-20(11-17)27-23(26-19)22-18-10-16-12-25(16,2)13-21(18)28-29-22/h4-5,11,14-16H,6-10,12-13H2,1-3H3/b23-22-/t14-,16-,25-/m1/s1 NSAGKILQOATIPV-JKVXYJNCSA-N 50587592 CHEMBL5090091::US11661419, Example 7 Interleukin-2 13 ChEMBL 10.1021/acsmedchemlett.1c00619 10.7270/Q2736VT6 34917248 Abdel-Magid, AF Therachem Research Medilab, LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50587592 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50587592&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 156494903 476023679 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51455285 CN(C(=O)C(F)(F)C1CCOCC1)c1ccc2[nH]c(nc2c1)-c1n[nH]c2C[C@@]3(C)C[C@H]3Cc12 InChI=1S/C24H25F2N5O2/c1-23-11-14(23)9-16-19(12-23)29-30-20(16)21-27-17-4-3-15(10-18(17)28-21)31(2)22(32)24(25,26)13-5-7-33-8-6-13/h3-4,10,13-14H,5-9,11-12H2,1-2H3/b21-20-/t14-,23-/m1/s1 TUMNWNHZHKQUPH-XGLQMIIHSA-N 50587593 CHEMBL5088468::US11661419, Example 11 Interleukin-2 34 ChEMBL 10.1021/acsmedchemlett.1c00619 10.7270/Q2736VT6 34917248 Abdel-Magid, AF Therachem Research Medilab, LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50587593 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50587593&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 156494916 476023680 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51455286 CCc1cc2[nH]c(nc2cc1N(C)C(=O)[C@H](C)N1CCOCC1)-c1n[nH]c2C[C@@]3(C)C[C@H]3Cc12 InChI=1S/C26H32N6O2/c1-5-16-10-19-20(12-22(16)31(4)25(33)15(2)32-6-8-34-9-7-32)28-24(27-19)23-18-11-17-13-26(17,3)14-21(18)29-30-23/h10,12,15,17H,5-9,11,13-14H2,1-4H3/b24-23-/t15-,17+,26+/m0/s1 UIWVNTWPRJDXMR-LCRCVHKUSA-N 50587594 CHEMBL5082562::US11661419, Example 18 Interleukin-2 91 ChEMBL 10.1021/acsmedchemlett.1c00619 10.7270/Q2736VT6 34917248 Abdel-Magid, AF Therachem Research Medilab, LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50587594 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50587594&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 156494843 476023681 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51455287 C[C@@H](N1CCOCC1=O)C(=O)N(C)c1cc(F)c2[nH]c(nc2c1)-c1n[nH]c2C[C@@]3(C)C[C@H]3Cc12 InChI=1S/C24H25FN6O3/c1-12(31-4-5-34-11-19(31)32)23(33)30(3)14-7-16(25)21-17(8-14)26-22(27-21)20-15-6-13-9-24(13,2)10-18(15)28-29-20/h7-8,12-13H,4-6,9-11H2,1-3H3/b22-20+/t12-,13-,24-/m1/s1 XMCOPDGSXZPBLG-NPMREBPMSA-N 50587595 CHEMBL5083169::US11661419, Example 23 Interleukin-2 304 ChEMBL 10.1021/acsmedchemlett.1c00619 10.7270/Q2736VT6 34917248 Abdel-Magid, AF Therachem Research Medilab, LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50587595 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50587595&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 156494905 476023682 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51455288 CN(C(=O)CN1CCOCC1=O)c1cc2nc([nH]c2cc1C)-c1n[nH]c2C[C@@]3(C)C[C@H]3Cc12 InChI=1S/C24H26N6O3/c1-13-6-16-17(8-19(13)29(3)20(31)11-30-4-5-33-12-21(30)32)26-23(25-16)22-15-7-14-9-24(14,2)10-18(15)27-28-22/h6,8,14H,4-5,7,9-12H2,1-3H3/b23-22-/t14-,24-/m1/s1 KQJNZVQZXGQSKR-GLQUDOHQSA-N 50587596 CHEMBL5086824::US11661419, Example 36 Interleukin-2 96 ChEMBL 10.1021/acsmedchemlett.1c00619 10.7270/Q2736VT6 34917248 Abdel-Magid, AF Therachem Research Medilab, LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50587596 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50587596&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 156495003 476023683 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51455289 C[C@H](N1CCOCC1)C(=O)N(C)c1cc(O)c2[nH]c(nc2c1)-c1n[nH]c2C[C@@]3(C)C[C@H]3Cc12 InChI=1S/C24H28N6O3/c1-13(30-4-6-33-7-5-30)23(32)29(3)15-9-17-21(19(31)10-15)26-22(25-17)20-16-8-14-11-24(14,2)12-18(16)27-28-20/h9-10,13-14,31H,4-8,11-12H2,1-3H3/b22-20+/t13-,14+,24+/m0/s1 KLGTXOTYAQWSNA-PNQBYWIGSA-N 50587597 CHEMBL5079033::US11661419, Example 39 Interleukin-2 82 ChEMBL 10.1021/acsmedchemlett.1c00619 10.7270/Q2736VT6 34917248 Abdel-Magid, AF Therachem Research Medilab, LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50587597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50587597&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 156494987 476023684 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51455290 C[C@H](N1CCOCC1)C(=O)N(C)c1cc2nc([nH]c2c(F)c1C)-c1n[nH]c2C[C@@]3(C)C[C@H]3Cc12 InChI=1S/C25H29FN6O2/c1-13-19(31(4)24(33)14(2)32-5-7-34-8-6-32)10-17-22(20(13)26)28-23(27-17)21-16-9-15-11-25(15,3)12-18(16)29-30-21/h10,14-15H,5-9,11-12H2,1-4H3/b23-21+/t14-,15+,25+/m0/s1 KXUPIFJFUKBMEU-WOZOTIFNSA-N 50587598 CHEMBL5074957::US11661419, Example 46 Interleukin-2 47 ChEMBL 10.1021/acsmedchemlett.1c00619 10.7270/Q2736VT6 34917248 Abdel-Magid, AF Therachem Research Medilab, LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50587598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50587598&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 156494845 476023685 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51455291 C[C@H](N1CCOCC1)C(=O)N(C)c1cc2nc([nH]c2cc1C)-c1n[nH]c2C[C@]3(C)[C@H](Cc12)C3(F)F InChI=1S/C25H28F2N6O2/c1-13-9-16-17(11-19(13)32(4)23(34)14(2)33-5-7-35-8-6-33)29-22(28-16)21-15-10-20-24(3,25(20,26)27)12-18(15)30-31-21/h9,11,14,20H,5-8,10,12H2,1-4H3/b22-21-/t14-,20-,24+/m0/s1 NPRMAJLSWMIITC-AHVXVNFKSA-N 50587599 CHEMBL5087453::US11661419, Example 53 Interleukin-2 10.0 ChEMBL 10.1021/acsmedchemlett.1c00619 10.7270/Q2736VT6 34917248 Abdel-Magid, AF Therachem Research Medilab, LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50587599 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50587599&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 156494869 476023686 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51435269 Cc1n[nH]c(C)c1CCCOc1cc(OCCCc2cn(CCOCCOCCOCCOCCNC(=O)C3CCC(CN4C(=O)C=CC4=O)CC3)nn2)cc(c1)C(O)=O InChI=1S/C42H59N7O11/c1-30-38(31(2)45-44-30)6-4-16-60-37-26-34(42(53)54)25-36(27-37)59-15-3-5-35-29-48(47-46-35)14-18-56-20-22-58-24-23-57-21-19-55-17-13-43-41(52)33-9-7-32(8-10-33)28-49-39(50)11-12-40(49)51/h11-12,25-27,29,32-33H,3-10,13-24,28H2,1-2H3,(H,43,52)(H,44,45)(H,53,54) AVALWFKKPLBJCO-UHFFFAOYSA-N 50579802 CHEMBL5081901 Interleukin-2 851 ChEMBL 10.1021/acs.jmedchem.1c01426 10.7270/Q20005XS 34542267 Liu, F; Ul Amin, T; Liang, D; Park, MS; Alhamadsheh, MM University of the Pacific http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50579802 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50579802&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 166627887 476024807 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51435270 Cc1n[nH]c(C)c1CCCOc1cc(OCCCc2cn(CCOCCOCCOCCOCCNC(=O)C3CCC(CN4C(=O)C=CC4=O)CC3)nn2)cc(c1)C(O)=O InChI=1S/C42H59N7O11/c1-30-38(31(2)45-44-30)6-4-16-60-37-26-34(42(53)54)25-36(27-37)59-15-3-5-35-29-48(47-46-35)14-18-56-20-22-58-24-23-57-21-19-55-17-13-43-41(52)33-9-7-32(8-10-33)28-49-39(50)11-12-40(49)51/h11-12,25-27,29,32-33H,3-10,13-24,28H2,1-2H3,(H,43,52)(H,44,45)(H,53,54) AVALWFKKPLBJCO-UHFFFAOYSA-N 50579802 CHEMBL5081901 Interleukin-2 0.609 ChEMBL 10.1021/acs.jmedchem.1c01426 10.7270/Q20005XS 34542267 Liu, F; Ul Amin, T; Liang, D; Park, MS; Alhamadsheh, MM University of the Pacific http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50579802 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50579802&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 166627887 476024807 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51485073 C[C@H]1CC(=O)c2ccc(Nc3cc4c(cnc(OC5CC5)c4cn3)[C@](C)(N)C3CC3)cc2C11CC1 InChI=1S/C29H32N4O2/c1-16-11-25(34)20-8-5-18(12-23(20)29(16)9-10-29)33-26-13-21-22(14-31-26)27(35-19-6-7-19)32-15-24(21)28(2,30)17-3-4-17/h5,8,12-17,19H,3-4,6-7,9-11,30H2,1-2H3,(H,31,33)/t16-,28+/m0/s1 GWYYJSPXAHPDSQ-DEXQXJORSA-N 50598492 CHEMBL5205694 Interleukin-2 9.4 ChEMBL 10.7270/Q29G5RT0 35696642 Zhu, Q; Chen, N; Tian, X; Zhou, Y; You, Q; Xu, X China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50598492 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50598492&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 168296935 482609344 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51018434 CC(C)CC([NH+]=C(N)N)C(=O)NCC(=O)N1CCC(CC1)c1cc(nn1C)-c1ccc(OCc2ccc(o2)C([O-])=O)c(Cl)c1Cl InChI=1S/C30H37Cl2N7O6/c1-16(2)12-21(36-30(33)34)28(41)35-14-25(40)39-10-8-17(9-11-39)22-13-20(37-38(22)3)19-5-7-23(27(32)26(19)31)44-15-18-4-6-24(45-18)29(42)43/h4-7,13,16-17,21H,8-12,14-15H2,1-3H3,(H,35,41)(H,42,43)(H4,33,34,36) VNZHOIDQBPFEJU-UHFFFAOYSA-N 50229786 5-[2,3-DICHLORO-4-(5-{1-[2-(2-GUANIDINO-4-METHYL-PENTANOYLAMINO)-ACETYL]-PIPERIDIN-4-YL}-1-METHYL-1H-PYRAZOL-3-YL)-PHENOXYMETHYL]-FURAN-2-CARBOXYLIC ACID::5-[2,3-Dichloro-4-(5-{1-[2-((R)-2-guanidino-4-methyl-1-oxo-pentylamino)-acetyl]-piperidin-4-yl}-1-methyl-1H-pyrazol-3-yl)-phenoxymethyl]-furan-2-carboxylic acid::5-[2,3-Dichloro-4-(5-{1-[2-((R)-2-guanidino-4-methyl-pentanoylamino)-acetyl]-piperidin-4-yl}-1-methyl-1H-pyrazol-3-yl)-phenoxymethyl]-furan-2-carboxylic acid::CHEMBL429852::SP-4206 Interleukin-2 60000 ChEMBL 10.7270/Q2H70M1K 34214508 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50229786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50229786&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 91935514 104098213 47417 CHEMBL429852 ZINC03990365 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 1M47,1M48,1M49,1M4C,1PW6,1PY2,1QVN,1Z92,2B5I,5LQB,5UTZ,6YE3,7DR4,7M2G,7RA9 Interleukin-2 IL2_HUMAN P60568 P01585 51572829 OC(=O)C(F)(F)F.CN(CCCCCC(=O)Nc1ccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c2c1)CC[C@@H](c1ccccc1)n1cc(NC(=O)c2n[nH]c3CC(C)(C)CCc23)cn1 InChI=1S/C42H49N9O6.C2HF3O2/c1-42(2)19-17-30-32(23-42)47-48-37(30)39(55)45-28-24-43-50(25-28)33(26-10-6-4-7-11-26)18-21-49(3)20-9-5-8-12-35(52)44-27-13-14-29-31(22-27)41(57)51(40(29)56)34-15-16-36(53)46-38(34)54;3-2(4,5)1(6)7/h4,6-7,10-11,13-14,22,24-25,33-34H,5,8-9,12,15-21,23H2,1-3H3,(H,44,52)(H,45,55)(H,47,48)(H,46,53,54);(H,6,7)/t33-,34?;/m0./s1 OKATVMWRQXIGFK-GBIFBIGNSA-N 50632600 CHEMBL5398436 Interleukin-2 Homo sapiens 25 ChEMBL 10.1021/acs.jmedchem.2c02078 10.7270/Q26W9GK8 36959108 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50632600 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50632600&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 6YE3,7DR4,5UTZ,2B5I,1Z92,1PW6,1M4C,1M49,1M48,1M47,1PY2,1QVN,5LQB,7M2G,7YIX,6P65,8WYS,8WYR,6LXW,6LX3,8FSJ,6X96,8J6M,6X98,6X97,8J6O,7T76,7SGF Interleukin-2 IL2_HUMAN P60568 P01585 51572830 OC(=O)C(F)(F)F.CC1(C)CCc2c(C1)[nH]nc2C(=O)Nc1cnn(c1)[C@@H](CCN1CCN(CCC2CCN(CC2)c2ccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c3c2)CC1)c1ccccc1 InChI=1S/C46H56N10O5.C2HF3O2/c1-46(2)17-12-35-37(27-46)50-51-41(35)43(59)48-32-28-47-55(29-32)38(31-6-4-3-5-7-31)16-19-53-24-22-52(23-25-53)18-13-30-14-20-54(21-15-30)33-8-9-34-36(26-33)45(61)56(44(34)60)39-10-11-40(57)49-42(39)58;3-2(4,5)1(6)7/h3-9,26,28-30,38-39H,10-25,27H2,1-2H3,(H,48,59)(H,50,51)(H,49,57,58);(H,6,7)/t38-,39?;/m0./s1 VBIRDDQMZVGWLL-CYUXUBSPSA-N 50632601 CHEMBL5404419 Interleukin-2 Homo sapiens 35 ChEMBL 10.1021/acs.jmedchem.2c02078 10.7270/Q26W9GK8 36959108 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50632601 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50632601&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 6YE3,7DR4,5UTZ,2B5I,1Z92,1PW6,1M4C,1M49,1M48,1M47,1PY2,1QVN,5LQB,7M2G,7YIX,6P65,8WYS,8WYR,6LXW,6LX3,8FSJ,6X96,8J6M,6X98,6X97,8J6O,7T76,7SGF Interleukin-2 IL2_HUMAN P60568 P01585 51572831 COc1cc(C)c(Sc2cnc(NC(=O)c3ccc(CNC(C)C(C)(C)C)cc3)s2)cc1C(=O)N1CCN(CC1)C(C)=O InChI=1S/C32H41N5O4S2/c1-20-16-26(41-7)25(30(40)37-14-12-36(13-15-37)22(3)38)17-27(20)42-28-19-34-31(43-28)35-29(39)24-10-8-23(9-11-24)18-33-21(2)32(4,5)6/h8-11,16-17,19,21,33H,12-15,18H2,1-7H3,(H,34,35,39) ZHXNIYGJAOPMSO-UHFFFAOYSA-N 50186460 CHEMBL209148::N-(5-(5-(1-acetylpiperazine-4-carbonyl)-4-methoxy-2-methylphenylthio)thiazol-2-yl)-4-((3,3-dimethylbutan-2-ylamino)methyl)benzamide Interleukin-2 Homo sapiens 238 ChEMBL 10.1021/acs.jmedchem.2c02078 10.7270/Q26W9GK8 36959108 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50186460 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6408&target=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50186460&enzyme=Interleukin-2&column=ki&startPg=0&Increment=50&submit=Search MJG 3MJ2 11467730 104070509 CHEMBL209148 ZINC14191480 1 MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 6YE3,7DR4,5UTZ,2B5I,1Z92,1PW6,1M4C,1M49,1M48,1M47,1PY2,1QVN,5LQB,7M2G,7YIX,6P65,8WYS,8WYR,6LXW,6LX3,8FSJ,6X96,8J6M,6X98,6X97,8J6O,7T76,7SGF Interleukin-2 IL2_HUMAN P60568 P01585